Protein Name sirtuin 6
Organism Mus musculus
Gene ID 50721
Gene Symbol

Sirt6

UniProt P59941 (SIR6_MOUSE), Q3UKP1 (Q3UKP1_MOUSE)
Relationships Total Number of functionally related compound(s) : 115
Total Number of Articles : 148
Description

sirtuin 6

Gene Summary

Enables several functions, including NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); and transcription corepressor activity. Involved in several processes, including cellular protein modification process; negative regulation of nucleobase-containing compound metabolic process; and positive regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • NAD-dependent protein deacylase sirtuin-6
  • NAD-dependent deacetylase sirtuin-6
  • NAD-dependent protein deacetylase sirtuin-6
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Properties