| Protein Name | BCL2 binding component 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 27113 |
| Gene Symbol | BBC3 |
| UniProt | Q96PG8 (BBC3B_HUMAN), Q9BXH1 (BBC3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
97
Total Number of Articles : 92 |
Description |
BCL2 binding component 3 |
| Gene Summary |
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
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