Protein Name wingless-type MMTV integration site family, member 1
Organism Mus musculus
Gene ID 22408
Gene Symbol

Wnt1

UniProt P04426 (WNT1_MOUSE), Q3UR96 (Q3UR96_MOUSE)
Relationships Total Number of functionally related compound(s) : 108
Total Number of Articles : 119
Description

wingless-type MMTV integration site family, member 1

Gene Summary

Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; regulation of cellular protein metabolic process; and ubiquitin-dependent SMAD protein catabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • proto-oncogene Wnt-1
  • proto-oncogene Int-1
  • proto-oncogene protein Wnt-1
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Properties