Protein Name estrogen receptor 2
Organism Rattus norvegicus
Gene ID 25149
Gene Symbol

Esr2

UniProt Q62986 (ESR2_RAT), Q59IV8 (Q59IV8_RAT)
Relationships Total Number of functionally related compound(s) : 289
Total Number of Articles : 507
Description

estrogen receptor 2

Gene Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Located in several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (estrogen receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • estrogen receptor beta
  • estrogen receptor 2 (ER beta)
  • estrogen receptor 2 beta
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Properties