Protein Name C-C motif chemokine receptor 7
Organism Homo sapiens
Gene ID 1236
Gene Symbol

CCR7

UniProt P32248 (CCR7_HUMAN), A0N0Q0 (A0N0Q0_HUMAN), J3KSS9 (J3KSS9_HUMAN)
Relationships Total Number of functionally related compound(s) : 175
Total Number of Articles : 202
Description

C-C motif chemokine receptor 7

Gene Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

synonyms
  • C-C chemokine receptor type 7
  • Bukitt's lymphoma receptor 2
  • CC chemokine receptor 7
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Properties