Protein Name hydroxysteroid 11-beta dehydrogenase 2
Organism Rattus norvegicus
Gene ID 25117
Gene Symbol

Hsd11b2

UniProt P50233 (DHI2_RAT)
Relationships Total Number of functionally related compound(s) : 99
Total Number of Articles : 135
Description

hydroxysteroid 11-beta dehydrogenase 2

Gene Summary

Enables NAD binding activity and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to food. Located in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • 11-beta-hydroxysteroid dehydrogenase type 2
  • 11-DH2
  • 11-beta-HSD2
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Properties