Protein Name Ras association domain family member 1
Organism Homo sapiens
Gene ID 11186
Gene Symbol

RASSF1

UniProt Q9NS23 (RASF1_HUMAN)
Relationships Total Number of functionally related compound(s) : 132
Total Number of Articles : 191
Description

Ras association domain family member 1

Gene Summary

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

synonyms
  • ras association domain-containing protein 1
  • Ras association (RalGDS/AF-6) domain family member 1
  • WUGSC:H_LUCA12.5
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Properties