Protein Name hemoglobin subunit beta
Organism Homo sapiens
Gene ID 3043
Gene Symbol

HBB

UniProt P68871 (HBB_HUMAN), D9YZU5 (D9YZU5_HUMAN)
Relationships Total Number of functionally related compound(s) : 162
Total Number of Articles : 192
Description

hemoglobin subunit beta

Gene Summary

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

synonyms
  • hemoglobin subunit beta
  • beta globin chain
  • hemoglobin beta subunit
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Properties