| Protein Name | histone deacetylase 4 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9759 |
| Gene Symbol | HDAC4 |
| UniProt | P56524 (HDAC4_HUMAN), A0A7I2SVS4 (A0A7I2SVS4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
170
Total Number of Articles : 194 |
Description |
histone deacetylase 4 |
| Gene Summary |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] |
| synonyms |
|
| Properties | |