Protein Name RUNX family transcription factor 1
Organism Homo sapiens
Gene ID 861
Gene Symbol

RUNX1

UniProt Q01196 (RUNX1_HUMAN)
Relationships Total Number of functionally related compound(s) : 238
Total Number of Articles : 303
Description

RUNX family transcription factor 1

Gene Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • runt-related transcription factor 1
  • AML1-ETO fusion
  • AML1-ETO fusion protein
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Properties