Protein Name uncoupling protein 2 (mitochondrial, proton carrier)
Organism Mus musculus
Gene ID 22228
Gene Symbol


UniProt P70406 (UCP2_MOUSE), Q549J5 (Q549J5_MOUSE)
Relationships Total Number of functionally related compound(s) : 211
Total Number of Articles : 294

uncoupling protein 2 (mitochondrial, proton carrier)

Gene Summary

Predicted to enable oxidative phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

  • dicarboxylate carrier SLC25A8
  • mitochondrial uncoupling protein 2
  • solute carrier family 25 member 8
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