Protein Name FAT atypical cadherin 1
Organism Mus musculus
Gene ID 14107
Gene Symbol

Fat1

UniProt F2Z4A3 (F2Z4A3_MOUSE), A0A087WRT4 (A0A087WRT4_MOUSE), A0A1L1SQU7 (A0A1L1SQU7_MOUSE)
Relationships Total Number of functionally related compound(s) : 137
Total Number of Articles : 171
Description

FAT atypical cadherin 1

Gene Summary

Involved in epithelial cell morphogenesis; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis; and lens development in camera-type eye. Acts upstream of or within actin filament organization; cell-cell adhesion; and establishment or maintenance of cell polarity. Located in several cellular components, including apical plasma membrane; filopodium; and lamellipodium. Is active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study facioscapulohumeral muscular dystrophy and nephrotic syndrome. Orthologous to human FAT1 (FAT atypical cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • protocadherin Fat 1
  • FAT tumor suppressor homolog 1
  • fat 1 cadherin
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Properties