| Protein Name | neural precursor cell expressed, developmentally down-regulated gene 4-like |
|---|---|
| Organism | Mus musculus |
| Gene ID | 83814 |
| Gene Symbol | Nedd4l |
| UniProt | G3X9H8 (G3X9H8_MOUSE), E9PXB7 (E9PXB7_MOUSE), A0A494BAG2 (A0A494BAG2_MOUSE), A0A494B953 (A0A494B953_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
59
Total Number of Articles : 56 |
Description |
neural precursor cell expressed, developmentally down-regulated gene 4-like |
| Gene Summary |
Enables sodium channel inhibitor activity and ubiquitin protein ligase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization; regulation protein catabolic process at postsynapse; and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of monoatomic ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025] |
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