Protein Name Janus kinase 2
Organism Mus musculus
Gene ID 16452
Gene Symbol

Jak2

UniProt Q62120 (JAK2_MOUSE)
Relationships Total Number of functionally related compound(s) : 466
Total Number of Articles : 693
Description

Janus kinase 2

Gene Summary

Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to lipid; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tyrosine-protein kinase JAK2
  • JAK-2
  • Fd17
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Properties