Protein Name reelin
Organism Homo sapiens
Gene ID 5649
Gene Symbol

RELN

UniProt P78509 (RELN_HUMAN)
Relationships Total Number of functionally related compound(s) : 89
Total Number of Articles : 111
Description

reelin

Gene Summary

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

synonyms
  • reelin
  • ETL7
  • LIS2
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Properties