Protein Name polypyrimidine tract binding protein 1
Organism Mus musculus
Gene ID 19205
Gene Symbol

Ptbp1

UniProt Q8BGJ5 (Q8BGJ5_MOUSE), Q8CB58 (Q8CB58_MOUSE), Q922I7 (Q922I7_MOUSE)
Relationships Total Number of functionally related compound(s) : 31
Total Number of Articles : 41
Description

polypyrimidine tract binding protein 1

Gene Summary

Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome and negative regulation of neuron differentiation. Acts upstream of with a negative effect on gene expression. Acts upstream of or within neurogenesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; central nervous system ganglion; connective tissue; genitourinary system; and sensory organ. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • polypyrimidine tract-binding protein 1
  • heterogeneous nuclear ribonucleoprotein I
  • hnRNP I
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Properties