Protein Name fragile X messenger ribonucleoprotein 1
Organism Mus musculus
Gene ID 14265
Gene Symbol

Fmr1

UniProt Q6AXB7 (Q6AXB7_MOUSE), E9QNF5 (E9QNF5_MOUSE), E9QAT0 (E9QAT0_MOUSE), Q547R0 (Q547R0_MOUSE), Q8BPK8 (Q8BPK8_MOUSE)
Relationships Total Number of functionally related compound(s) : 179
Total Number of Articles : 240
Description

fragile X messenger ribonucleoprotein 1

Gene Summary

Enables several functions, including RNA binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular protein metabolic process; and regulation of mRNA metabolic process. Acts upstream of or within central nervous system development and dendritic spine development. Located in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic ribonucleoprotein granule; and filopodium. Is extrinsic component of plasma membrane. Part of SMN complex; mRNA cap binding activity complex; and polysome. Is active in presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Used to study autism spectrum disorder; fragile X syndrome; and fragile X-associated tremor/ataxia syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (FMRP translational regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • fragile X messenger ribonucleoprotein 1
  • FMRP translational regulator 1
  • synaptic functional regulator FMR1
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Properties