Protein Name beclin 1
Organism Rattus norvegicus
Gene ID 114558
Gene Symbol

Becn1

UniProt Q91XJ1 (BECN1_RAT)
Relationships Total Number of functionally related compound(s) : 319
Total Number of Articles : 462
Description

beclin 1

Gene Summary

Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • beclin-1
  • beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
  • beclin 1, autophagy related
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Properties