CPRiL

RASGRP2

RAS guanyl releasing protein 2

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

• RAS guanyl-releasing protein 2
• F25B3.3 kinase-like protein
• RAS guanyl nucleotide-releasing protein 2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
calcium and DAG-regulated guanine nucleotide exchange factor I
calcium and diacylglycerol-regulated guanine nucleotide exchange factor I
cdc25-like protein
guanine exchange factor MCG7
CALDAG-GEFI
CDC25L