Protein Name milk fat globule EGF and factor V/VIII domain containing
Organism Homo sapiens
Gene ID 4240
Gene Symbol

MFGE8

UniProt Q08431 (MFGM_HUMAN), B3KTQ2 (B3KTQ2_HUMAN), B4E396 (B4E396_HUMAN)
Relationships Total Number of functionally related compound(s) : 165
Total Number of Articles : 200
Description

milk fat globule EGF and factor V/VIII domain containing

Gene Summary

This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

synonyms
  • lactadherin
  • O-acetyl disialoganglioside synthase
  • breast epithelial antigen BA46
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Properties