Protein Name jagged canonical Notch ligand 1
Organism Rattus norvegicus
Gene ID 29146
Gene Symbol

Jag1

UniProt Q63722 (JAG1_RAT)
Relationships Total Number of functionally related compound(s) : 57
Total Number of Articles : 57
Description

jagged canonical Notch ligand 1

Gene Summary

Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • protein jagged-1
  • jagged 1
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Properties