Protein Name aldo-keto reductase family 1 member C2
Organism Homo sapiens
Gene ID 1646
Gene Symbol

AKR1C2

UniProt P52895 (AK1C2_HUMAN), B4DK69 (B4DK69_HUMAN)
Relationships Total Number of functionally related compound(s) : 167
Total Number of Articles : 139
Description

aldo-keto reductase family 1 member C2

Gene Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

synonyms
  • aldo-keto reductase family 1 member C2
  • 3-alpha-HSD3
  • chlordecone reductase homolog HAKRD
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Properties