Protein Name SREBF chaperone
Organism Homo sapiens
Gene ID 22937
Gene Symbol

SCAP

UniProt Q12770 (SCAP_HUMAN), B7Z6H0 (B7Z6H0_HUMAN)
Relationships Total Number of functionally related compound(s) : 118
Total Number of Articles : 174
Description

SREBF chaperone

Gene Summary

This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

synonyms
  • sterol regulatory element-binding protein cleavage-activating protein
  • SREBP cleavage-activating protein
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Properties