Protein Name acetyl-CoA carboxylase beta
Organism Homo sapiens
Gene ID 32
Gene Symbol

ACACB

UniProt O00763 (ACACB_HUMAN)
Relationships Total Number of functionally related compound(s) : 74
Total Number of Articles : 90
Description

acetyl-CoA carboxylase beta

Gene Summary

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]

synonyms
  • acetyl-CoA carboxylase 2
  • acetyl-Coenzyme A carboxylase beta
  • ACACbeta
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Properties