Protein Name RB binding protein 4, chromatin remodeling factor
Organism Homo sapiens
Gene ID 5928
Gene Symbol


UniProt Q09028 (RBBP4_HUMAN)
Relationships Total Number of functionally related compound(s) : 143
Total Number of Articles : 165

RB binding protein 4, chromatin remodeling factor

Gene Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

  • histone-binding protein RBBP4
  • CAF-1 subunit C
  • CAF-I 48 kDa subunit
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