Protein Name fascin actin-bundling protein 1
Organism Homo sapiens
Gene ID 6624
Gene Symbol

FSCN1

UniProt Q16658 (FSCN1_HUMAN), A0A384MEG1 (A0A384MEG1_HUMAN), B3KTA3 (B3KTA3_HUMAN)
Relationships Total Number of functionally related compound(s) : 97
Total Number of Articles : 99
Description

fascin actin-bundling protein 1

Gene Summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

synonyms
  • fascin
  • 55 kDa actin-bundling protein
  • epididymis secretory sperm binding protein
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Properties