Protein Name RE1 silencing transcription factor
Organism Homo sapiens
Gene ID 5978
Gene Symbol

REST

UniProt Q13127 (REST_HUMAN), A0A1W2PQA1 (A0A1W2PQA1_HUMAN)
Relationships Total Number of functionally related compound(s) : 85
Total Number of Articles : 68
Description

RE1 silencing transcription factor

Gene Summary

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

synonyms
  • RE1-silencing transcription factor
  • neural-restrictive silencer factor
  • neuron restrictive silencer factor
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Properties