Protein Name acyl-Coenzyme A dehydrogenase, medium chain
Organism Mus musculus
Gene ID 11364
Gene Symbol

Acadm

UniProt P45952 (ACADM_MOUSE)
Relationships Total Number of functionally related compound(s) : 23
Total Number of Articles : 33
Description

acyl-Coenzyme A dehydrogenase, medium chain

Gene Summary

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]

synonyms
  • medium-chain specific acyl-CoA dehydrogenase, mitochondrial
  • MCAD
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Properties