Protein Name lysyl oxidase
Organism Homo sapiens
Gene ID 4015
Gene Symbol

LOX

UniProt P28300 (LYOX_HUMAN), B0AZT2 (B0AZT2_HUMAN), B7ZAJ4 (B7ZAJ4_HUMAN), D0PNI2 (D0PNI2_HUMAN)
Relationships Total Number of functionally related compound(s) : 567
Total Number of Articles : 574
Description

lysyl oxidase

Gene Summary

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]

synonyms
  • protein-lysine 6-oxidase
  • AAT10
Click to show/hide the synonyms
Properties