Protein Name RNA binding motif protein 8A
Organism Homo sapiens
Gene ID 9939
Gene Symbol

RBM8A

UniProt Q9Y5S9 (RBM8A_HUMAN), A0A023T787 (A0A023T787_HUMAN)
Relationships Total Number of functionally related compound(s) : 134
Total Number of Articles : 113
Description

RNA binding motif protein 8A

Gene Summary

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]

synonyms
  • RNA-binding protein 8A
  • BOV-1
  • RNA binding motif protein 8B
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Properties