Protein Name C-C motif chemokine receptor 1
Organism Homo sapiens
Gene ID 1230
Gene Symbol

CCR1

UniProt P32246 (CCR1_HUMAN), Q5U003 (Q5U003_HUMAN)
Relationships Total Number of functionally related compound(s) : 155
Total Number of Articles : 147
Description

C-C motif chemokine receptor 1

Gene Summary

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

synonyms
  • C-C chemokine receptor type 1
  • C-C CKR-1
  • CC-CKR-1
Click to show/hide the synonyms
Properties