Protein Name pre-mRNA processing factor 19
Organism Homo sapiens
Gene ID 27339
Gene Symbol

PRPF19

UniProt Q9UMS4 (PRP19_HUMAN)
Relationships Total Number of functionally related compound(s) : 39
Total Number of Articles : 24
Description

pre-mRNA processing factor 19

Gene Summary

Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; cellular protein metabolic process; and mRNA splicing, via spliceosome. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear speck; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • pre-mRNA-processing factor 19
  • PRP19/PSO4 homolog
  • PRP19/PSO4 pre-mRNA processing factor 19 homolog
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Properties