Protein Name neurofascin
Organism Homo sapiens
Gene ID 23114
Gene Symbol

NFASC

UniProt O94856 (NFASC_HUMAN), B4DRH7 (B4DRH7_HUMAN)
Relationships Total Number of functionally related compound(s) : 272
Total Number of Articles : 173
Description

neurofascin

Gene Summary

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

synonyms
  • neurofascin
  • neurofascin homolog
  • NEDCPMD
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Properties