Protein Name calreticulin
Organism Homo sapiens
Gene ID 811
Gene Symbol

CALR

UniProt P27797 (CALR_HUMAN), V9HW88 (V9HW88_HUMAN)
Relationships Total Number of functionally related compound(s) : 393
Total Number of Articles : 586
Description

calreticulin

Gene Summary

Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]

synonyms
  • calreticulin
  • CRP55
  • ERp60
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Properties