Protein Name prostaglandin E receptor 4
Organism Rattus norvegicus
Gene ID 84023
Gene Symbol


UniProt P43114 (PE2R4_RAT), A0A0G2JSM6 (A0A0G2JSM6_RAT)
Relationships Total Number of functionally related compound(s) : 135
Total Number of Articles : 182

prostaglandin E receptor 4

Gene Summary

Enables prostaglandin E receptor activity. Involved in several processes, including regulation of circadian sleep/wake cycle, sleep; regulation of cytokine production; and regulation of secretion. Located in several cellular components, including neuron projection terminus; neuronal cell body; and nuclear membrane. Used to study acute kidney failure; cystitis; end stage renal disease; myocarditis; and osteoporosis. Biomarker of retinal ischemia and transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

  • prostaglandin E2 receptor EP4 subtype
  • PGE receptor, EP4 subtype
  • PGE2 receptor EP4 subtype
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