Protein Name Fc alpha receptor
Organism Homo sapiens
Gene ID 2204
Gene Symbol

FCAR

UniProt P24071 (FCAR_HUMAN), A0A024R4N4 (A0A024R4N4_HUMAN), A0A024R4R4 (A0A024R4R4_HUMAN)
Relationships Total Number of functionally related compound(s) : 51
Total Number of Articles : 56
Description

Fc alpha receptor

Gene Summary

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • immunoglobulin alpha Fc receptor
  • Fc fragment of IgA receptor
  • Fc fragment of IgA, receptor for
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Properties