Protein Name TTK protein kinase
Organism Homo sapiens
Gene ID 7272
Gene Symbol

TTK

UniProt P33981 (TTK_HUMAN)
Relationships Total Number of functionally related compound(s) : 138
Total Number of Articles : 110
Description

TTK protein kinase

Gene Summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

synonyms
  • dual specificity protein kinase TTK
  • cancer/testis antigen 96
  • monopolar spindle 1 kinase
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Properties