PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
27896877-9	2017	Our results indicated that BCGE promoted bone repair via increasing the bone mass, the volume of bone, promoting osteocalcin secretion after vancomycin-calcium sulfate treatment.	bcge	27-31	osteocalcin	Oryctolagus cuniculus	113-124
30030632-8	2018	IMH revealed that HAP/TCP/Sr induced most noticeable increase of nuclear factor kappa beta 105 (NFkB 105), osteoprotegerin (OPG), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP 2/4), collagen type 1alpha (COL-1alpha), interleukin 1 (IL-1) with comparison to intact leg; NFkB 105 and OPG rather than pure HAP/TCP or sham bone.	6-N-hydroxylaminopurine	18-21	osteocalcin	Oryctolagus cuniculus	130-141
30030632-8	2018	IMH revealed that HAP/TCP/Sr induced most noticeable increase of nuclear factor kappa beta 105 (NFkB 105), osteoprotegerin (OPG), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP 2/4), collagen type 1alpha (COL-1alpha), interleukin 1 (IL-1) with comparison to intact leg; NFkB 105 and OPG rather than pure HAP/TCP or sham bone.	6-N-hydroxylaminopurine	18-21	osteocalcin	Oryctolagus cuniculus	143-145
29581732-6	2018	ALP, Ct I and osteocalcin activities were higher in cells cultured in dexamethasone, BMP-2 and TGFbeta compared with the activities in control cells.	Dexamethasone	70-83	osteocalcin	Oryctolagus cuniculus	14-25
27283081-6	2017	The CaS/SB group showed a larger portion of mature lamellar bone and a higher level of mineralization of bone trabeculae, characterized by more intense labeling with osteocalcin compared with the control group in the immunohistochemical analysis.	Calcium Sulfate	4-7	osteocalcin	Oryctolagus cuniculus	166-177
28460213-0	2017	Use of Low-Dose Alendronate Improves Cranial Bone Repair and Is Associated With an Increase of Osteocalcin: An Experimental Study.	Alendronate	16-27	osteocalcin	Oryctolagus cuniculus	95-106
28460213-1	2017	PURPOSE: The objective of the present study was to evaluate cranial bone repair and remodeling after systemic application of alendronate (ALN), using histologic analysis, histometric analysis, and immunohistochemistry (osteocalcin).	Alendronate	125-136	osteocalcin	Oryctolagus cuniculus	219-230
3497183-4	1987	4-micron cryosections of formaldehyde-fixed tooth germs showed positive immunocytochemical staining for osteocalcin in dentin and odontoblasts.	Formaldehyde	25-37	osteocalcin	Oryctolagus cuniculus	104-115
32982168-9	2020	Furthermore, immunofluorescence double staining and histology analysis confirmed that SAA-BTL significantly increased the expression of P-HDAC3, collagen II, RUNX2, VEGFA, and osteocalcin in vivo; accelerated endochondral ossification turnover from cartilage to bone; and promoted long bone healing of nonunion defects.	saa-btl	86-93	osteocalcin	Oryctolagus cuniculus	176-187
30030632-8	2018	IMH revealed that HAP/TCP/Sr induced most noticeable increase of nuclear factor kappa beta 105 (NFkB 105), osteoprotegerin (OPG), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP 2/4), collagen type 1alpha (COL-1alpha), interleukin 1 (IL-1) with comparison to intact leg; NFkB 105 and OPG rather than pure HAP/TCP or sham bone.	tcp	22-25	osteocalcin	Oryctolagus cuniculus	130-141
30030632-8	2018	IMH revealed that HAP/TCP/Sr induced most noticeable increase of nuclear factor kappa beta 105 (NFkB 105), osteoprotegerin (OPG), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP 2/4), collagen type 1alpha (COL-1alpha), interleukin 1 (IL-1) with comparison to intact leg; NFkB 105 and OPG rather than pure HAP/TCP or sham bone.	tcp	22-25	osteocalcin	Oryctolagus cuniculus	143-145
29257271-3	2018	Treatment with naringin markedly protected against the steroid-induced decrease in serum osteocalcin levels, and the rate of osteonecrosis in a model of SANFH.	naringin	15-23	osteocalcin	Oryctolagus cuniculus	89-100
29257271-3	2018	Treatment with naringin markedly protected against the steroid-induced decrease in serum osteocalcin levels, and the rate of osteonecrosis in a model of SANFH.	Steroids	55-62	osteocalcin	Oryctolagus cuniculus	89-100
29163169-8	2017	The results indicated that high dose of vancomycin significantly decreased bone mass and inhibited osteocalcin secretion; icariin increased these indicators compared with the single vancomycin treatment.	Vancomycin	40-50	osteocalcin	Oryctolagus cuniculus	99-110
27283081-6	2017	The CaS/SB group showed a larger portion of mature lamellar bone and a higher level of mineralization of bone trabeculae, characterized by more intense labeling with osteocalcin compared with the control group in the immunohistochemical analysis.	Butyric Acid	8-10	osteocalcin	Oryctolagus cuniculus	166-177
27283081-7	2017	The number of osteocalcin-positive cells within the central area of the augmented sinus was significantly higher in the CaS/SB group than in the control group (179 +- 26.0 mm2 and 123 +- 33.2 mm2 , respectively, p = 0.027).	Calcium Sulfate	120-123	osteocalcin	Oryctolagus cuniculus	14-25
27283081-7	2017	The number of osteocalcin-positive cells within the central area of the augmented sinus was significantly higher in the CaS/SB group than in the control group (179 +- 26.0 mm2 and 123 +- 33.2 mm2 , respectively, p = 0.027).	Butyric Acid	124-126	osteocalcin	Oryctolagus cuniculus	14-25
28674665-9	2017	At 6 and 12 weeks, the highest levels of OC and OPN markers were found in the OPG-chitosan gel group, followed by the chitosan gel group.	Chitosan	82-90	osteocalcin	Oryctolagus cuniculus	41-43
27896877-9	2017	Our results indicated that BCGE promoted bone repair via increasing the bone mass, the volume of bone, promoting osteocalcin secretion after vancomycin-calcium sulfate treatment.	Vancomycin	141-151	osteocalcin	Oryctolagus cuniculus	113-124
25096719-7	2014	LF-impregnated PMs generated significantly greater ALP activity, calcium deposition, and mRNA expression of osteocalcin and osteopontin compared with PMs.	Promethium	15-18	osteocalcin	Oryctolagus cuniculus	108-119
27259301-7	2015	The cells proliferation and the mRNA expressions of collagen I and osteocalcin were detected by MTT and RT-PCR assays, respectively and alkaline phosphatase(ALP)and calcium concentration at different induction time were detected.	monooxyethylene trimethylolpropane tristearate	96-99	osteocalcin	Oryctolagus cuniculus	67-78
26179165-12	2015	In addition, MSCs cultured in BCP hybrid scaffolds produced more messenger RNA (mRNA) for osteopontin, osteocalcin, Runx2, and leptin receptor (leptin-R) than those cultured in coralline HA hybrid scaffolds.	hydroxyapatite-beta tricalcium phosphate	30-33	osteocalcin	Oryctolagus cuniculus	103-114
25294892-8	2015	The expression of HIF-1alpha, VEGF, BMP-2, and OCN, indicated by immunohistochemical staining, was higher in the DFO group compared with other groups.	Deferoxamine	113-116	osteocalcin	Oryctolagus cuniculus	47-50
26869789-6	2016	Compared with the PET group and the COL/PET group, SIM could induce bone marrow stromal cells" osteoblastic differentiation, high alkaline phosphatase activity, more mineralization deposition, and more expression of osteoblast-related genes, such as osteocalcin, runt-related transcription factor 2, bone morphogenetic protein-2, and vascular endothelial growth factor, in the SIM/COL/PET group.	Simvastatin	51-54	osteocalcin	Oryctolagus cuniculus	250-261
25968462-8	2015	For the mechanistic study, our in vitro tests suggested that icaritin enhanced the expression of osteogenesis related genes COL1alpha, osteocalcin, RUNX2, and BMP-2 while inhibited adipogenesis related genes C/EBP-ss, PPAR-gamma, and aP2 of rabbit BMSCs.	icaritin	61-69	osteocalcin	Oryctolagus cuniculus	135-146
25045131-10	2015	Increased osteon and thus enhanced network of blood vessel formation, and osteocalcin expression were observed in the doped TCP scaffolds.	tricalcium phosphate	124-127	osteocalcin	Oryctolagus cuniculus	74-85
25000369-7	2014	RESULTS: The levels of PPARgamma gene expression were decreased while the levels of osteocalcin and Runx2 gene expression were increased in rabbits treated with dexamethasone and recombinant adenovirus shuttle vector carrying siRNA targeting PPARgamma gene (Group S), compared to rabbits treated either with dexamethasone alone (Group M) or with both dexamethasone and a vector carrying irrelative sequence (Group Con).	Dexamethasone	161-174	osteocalcin	Oryctolagus cuniculus	84-95
23765602-0	2014	Magnesium-based bone implants: immunohistochemical analysis of peri-implant osteogenesis by evaluation of osteopontin and osteocalcin expression.	Magnesium	0-9	osteocalcin	Oryctolagus cuniculus	122-133
25033438-4	2014	In CS/OS composites group, elevated mRNA levels of key osteogenic genes including bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (Runx2), osterix (Osx), and osteocalcin (OCN) were observed.	Cesium	3-5	osteocalcin	Oryctolagus cuniculus	184-195
25033438-4	2014	In CS/OS composites group, elevated mRNA levels of key osteogenic genes including bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (Runx2), osterix (Osx), and osteocalcin (OCN) were observed.	Cesium	3-5	osteocalcin	Oryctolagus cuniculus	197-200
25033438-4	2014	In CS/OS composites group, elevated mRNA levels of key osteogenic genes including bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (Runx2), osterix (Osx), and osteocalcin (OCN) were observed.	Osmium	6-8	osteocalcin	Oryctolagus cuniculus	184-195
25033438-4	2014	In CS/OS composites group, elevated mRNA levels of key osteogenic genes including bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (Runx2), osterix (Osx), and osteocalcin (OCN) were observed.	Osmium	6-8	osteocalcin	Oryctolagus cuniculus	197-200
22526493-9	2013	We theorize that globular accretions observed in SEM analysis may be calcified matrix resulting from osteocalcin secreted by osteoblasts binding calcium contained in fetal bovine serum.	Calcium	145-152	osteocalcin	Oryctolagus cuniculus	101-112
23806956-8	2013	Expression of osteocalcin and osteopontin in cells treated with oxysterol 49 and BMP-2 was equivalent.	Oxysterols	64-73	osteocalcin	Oryctolagus cuniculus	14-25
22241502-12	2012	However, in comparison with the model group, the empty lacuna ratio of Huogu II group and Huogu II plus Ach group decreased obviously in addition to the levels of serum BGP and BMP2, and the expressions of BMP2 mRNA, BrdU, and SDF-1 increased significantly.	Acetylcholine	104-107	osteocalcin	Oryctolagus cuniculus	169-172
22513050-0	2012	Bovine hydroxyapatite (Bio-Oss( )) induces osteocalcin, RANK-L and osteoprotegerin expression in sinus lift of rabbits.	Durapatite	7-21	osteocalcin	Oryctolagus cuniculus	43-54
22320360-7	2012	The results showed that n-HA/PA composites had great bioactivity, demonstrating significant BMSC proliferation, active alkaline phosphatase secretion, and stimulating the expression of osteogenic proteins (bone morphogenetic protein 2 [BMP2], osteoprotegerin [OPG], osteopontin [OPN], collagen type I [Col I], and osteocalcin [OCN]), in comparison to the control (polyethylene).	n-ha	24-28	osteocalcin	Oryctolagus cuniculus	314-325
22320360-7	2012	The results showed that n-HA/PA composites had great bioactivity, demonstrating significant BMSC proliferation, active alkaline phosphatase secretion, and stimulating the expression of osteogenic proteins (bone morphogenetic protein 2 [BMP2], osteoprotegerin [OPG], osteopontin [OPN], collagen type I [Col I], and osteocalcin [OCN]), in comparison to the control (polyethylene).	Protactinium	29-31	osteocalcin	Oryctolagus cuniculus	314-325
34414453-10	2021	Propranolol also elevated mRNA and protein expression levels of BMP2, RunX2, COL-1 and OCN in tissue and cells, and decreased the expression of beta2-AR.	Propranolol	0-11	osteocalcin	Oryctolagus cuniculus	87-90
19338435-4	2009	The surface-phosphorylated poly (HEMA-co-MMA) promotes in vitro biomineralization, cell viability, cell adhesion, and expression of bone-specific markers such as osteocalcin and alkaline phosphatase.	HTR composite	27-45	osteocalcin	Oryctolagus cuniculus	162-173
11811561-8	2002	Serum osteocalcin and vertebral trabecular bone density were lower in the prednisolone-treated rabbits.	Prednisolone	74-86	osteocalcin	Oryctolagus cuniculus	6-17
7556201-5	1995	1H-NMR studies of rabbit osteocalcin gave a set of resonance assignments and NOEs which could be interpreted in terms of distance constraints.	Hydrogen	0-2	osteocalcin	Oryctolagus cuniculus	25-36
22242352-6	2011	The cell proliferation and the mRNA expressions of osteocalcin (OC) and core binding factor alpha1 (Cbfalpha1) were detected by MTT and RT-PCR, respectively.	monooxyethylene trimethylolpropane tristearate	128-131	osteocalcin	Oryctolagus cuniculus	51-62
22242352-6	2011	The cell proliferation and the mRNA expressions of osteocalcin (OC) and core binding factor alpha1 (Cbfalpha1) were detected by MTT and RT-PCR, respectively.	monooxyethylene trimethylolpropane tristearate	128-131	osteocalcin	Oryctolagus cuniculus	64-66
11774331-11	2002	Osteocalcin content was significantly higher in the beads containing alpha-TCP than it was in those without alpha-TCP.	alpha-tricalcium phosphate	69-78	osteocalcin	Oryctolagus cuniculus	0-11
11774331-11	2002	Osteocalcin content was significantly higher in the beads containing alpha-TCP than it was in those without alpha-TCP.	alpha-tricalcium phosphate	108-117	osteocalcin	Oryctolagus cuniculus	0-11
35357952-9	2022	Greater osteoblast differentiation potential, including higher osteocalcin (OCN) expression and mineralization potential, was found in osteoblasts treated with sBMAC.	sbmac	160-165	osteocalcin	Oryctolagus cuniculus	63-74
35357952-9	2022	Greater osteoblast differentiation potential, including higher osteocalcin (OCN) expression and mineralization potential, was found in osteoblasts treated with sBMAC.	sbmac	160-165	osteocalcin	Oryctolagus cuniculus	76-79
35372645-9	2022	Losartan treatment slightly increased osteocalcin positive osteoblasts on the surface of cancellous bone and did not affect bone matrix collagen type 1 content and did not change AGTR1, AGTR2 and pTAK1 signal molecule expression.	Losartan	0-8	osteocalcin	Oryctolagus cuniculus	38-49