PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25460026-8	2015	We found that Cot/Tlp-2 induced NFAT and COX-2 transcriptional activities were inhibited by AM404.	N-(4-hydroxyphenyl)arachidonylamide	92-97	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	14-17
24912162-3	2014	Here, we show that TPL-2 Ser-400 phosphorylation by IKK and TPL-2 Ser-443 autophosphorylation cooperated to trigger TPL-2 association with 14-3-3.	Serine	25-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	19-24
25316791-0	2014	Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.	Dinoprostone	45-49	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	34-38
25316791-4	2014	Following epithelial injury, IMFs sense innate or inflammatory signals and activate, via Tpl2, the cyclooxygenase-2 (Cox-2)-prostaglandin E2 (PGE2) pathway, which we show here to be essential for the epithelial homeostatic response.	Dinoprostone	124-140	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	89-93
25378393-7	2014	Unexpectedly, Tpl2 is an essential regulator of ROS production during TLR signaling.	Reactive Oxygen Species	48-51	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	14-18
24912162-3	2014	Here, we show that TPL-2 Ser-400 phosphorylation by IKK and TPL-2 Ser-443 autophosphorylation cooperated to trigger TPL-2 association with 14-3-3.	Serine	25-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	60-65
24912162-3	2014	Here, we show that TPL-2 Ser-400 phosphorylation by IKK and TPL-2 Ser-443 autophosphorylation cooperated to trigger TPL-2 association with 14-3-3.	Serine	25-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	60-65
24912162-3	2014	Here, we show that TPL-2 Ser-400 phosphorylation by IKK and TPL-2 Ser-443 autophosphorylation cooperated to trigger TPL-2 association with 14-3-3.	Serine	66-69	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	19-24
24912162-3	2014	Here, we show that TPL-2 Ser-400 phosphorylation by IKK and TPL-2 Ser-443 autophosphorylation cooperated to trigger TPL-2 association with 14-3-3.	Serine	66-69	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	60-65
24912162-3	2014	Here, we show that TPL-2 Ser-400 phosphorylation by IKK and TPL-2 Ser-443 autophosphorylation cooperated to trigger TPL-2 association with 14-3-3.	Serine	66-69	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	60-65
21868363-0	2011	Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.	Calcium	75-82	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-25
23533274-5	2013	Low TPL2 levels correlate with reduced lung cancer patient survival and accelerated onset and multiplicity of urethane-induced lung tumors in mice.	Urethane	110-118	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	4-8
22988300-0	2012	IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.	Serine	129-135	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-32
22988300-0	2012	IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.	Serine	129-135	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	123-128
22988300-5	2012	LPS activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C terminus, which controls TPL-2 signaling to ERK-1/2 independently of p105.	Serine	81-87	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	72-77
22988300-5	2012	LPS activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C terminus, which controls TPL-2 signaling to ERK-1/2 independently of p105.	Serine	81-87	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	126-131
22988300-6	2012	However, the identity of the protein kinase responsible for TPL-2 serine 400 phosphorylation remained unknown.	Serine	66-72	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	60-65
22988300-7	2012	In the present study, we show that TPL-2 serine 400 phosphorylation is mediated by IKK2.	Serine	41-47	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	35-40
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	Inositol 1,4,5-Trisphosphate	167-195	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	112-116
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-14
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	112-116
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	Inositol 1,4,5-Trisphosphate	197-202	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-14
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	Inositol 1,4,5-Trisphosphate	197-202	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	112-116
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	Calcium	232-239	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-14
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	Calcium	232-239	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	112-116
21868363-6	2011	Tpl2 also promoted Ca(2+) signals and cell migration from sphingosine 1-phosphate-responsive GPCRs, which also couple to Galpha(i); from Wnt5a; and from the interleukin-1beta (IL-1beta) receptor, a member of the Toll-IL-1R (TIR) domain family.	sphingosine 1-phosphate	58-81	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-4
21742493-0	2011	Discovery of indazoles as inhibitors of Tpl2 kinase.	Indazoles	13-22	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	40-44
21742493-1	2011	Synthesis, modeling and structure-activity relationship of indazoles as inhibitors of Tpl2 kinase are described.	Indazoles	59-68	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	86-90
21742493-2	2011	From a high throughput screening effort, we identified an indazole hit compound 5 that has a single digit micromolar Tpl2 activity.	Indazoles	58-66	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	117-121
21851209-0	2012	Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors.	3-Quinolinecarbonitrile	57-81	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	97-101
21851209-2	2012	The article describes the development of a robust pharmacophore model and the investigation of structure-activity relationship analysis of quinoline-3-carbonitrile derivatives reported for Tpl2 kinase inhibition.	3-Quinolinecarbonitrile	139-163	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	189-193
22675026-2	2012	Here we show that Cot/tpl2 regulates RSK, S6 ribosomal protein, and 4E-BP phosphorylation after stimulation of bone marrow-derived macrophages with lipopolysaccharide (LPS), poly I:C, or zymosan.	Poly I-C	174-182	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-26
22675026-2	2012	Here we show that Cot/tpl2 regulates RSK, S6 ribosomal protein, and 4E-BP phosphorylation after stimulation of bone marrow-derived macrophages with lipopolysaccharide (LPS), poly I:C, or zymosan.	Zymosan	187-194	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-26
25562798-9	2012	Mechanisms of drug resistance in melanoma to vemurafenib do not involve mutations in BRAF itself but are associated with a variety of molecular changes including RAF1 or COT gene over expression, activating mutations in RAS or increased activation of the receptor tyrosine kinase PDGFRbeta.	Vemurafenib	45-56	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	170-173
21862328-0	2011	Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.	thieno[3,2-d]pyrimidines	42-66	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	70-74
21862328-1	2011	We report here the synthesis and SAR of a new series of thieno[3,2-d]pyrimidines as potent Tpl2 kinase inhibitors.	thieno[3,2-d]pyrimidines	56-80	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	91-95
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	Inositol 1,4,5-Trisphosphate	167-195	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-14
21469113-6	2011	Furthermore, in zymosan- and polyI:C-stimulated macrophages, Cot/tpl2 mediates P-Ser473 Akt phosphorylation, increases IkappaBalpha levels and decreases NOS2 expression.	Zymosan	16-23	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	61-69
21469113-6	2011	Furthermore, in zymosan- and polyI:C-stimulated macrophages, Cot/tpl2 mediates P-Ser473 Akt phosphorylation, increases IkappaBalpha levels and decreases NOS2 expression.	Poly I	29-34	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	61-69
21336688-6	2011	The optimal substrate for EstF to hydrolyze among a panel of p-nitrophenyl esters (C2 to C16) was p-nitrophenyl butyrate (C4), with a K(m) of 0.46 mM.	p-nitrophenyl esters	61-81	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	26-30
21469113-6	2011	Furthermore, in zymosan- and polyI:C-stimulated macrophages, Cot/tpl2 mediates P-Ser473 Akt phosphorylation, increases IkappaBalpha levels and decreases NOS2 expression.	Carbon	35-36	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	61-69
21336688-6	2011	The optimal substrate for EstF to hydrolyze among a panel of p-nitrophenyl esters (C2 to C16) was p-nitrophenyl butyrate (C4), with a K(m) of 0.46 mM.	4-nitrophenyl butyrate	98-120	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	26-30
21336688-6	2011	The optimal substrate for EstF to hydrolyze among a panel of p-nitrophenyl esters (C2 to C16) was p-nitrophenyl butyrate (C4), with a K(m) of 0.46 mM.	imciromab pentetate	122-124	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	26-30
21182083-6	2011	IKK induced the phosphorylation of p65 directly on Ser-536 residue whereas phosphorylation on Ser 276 residue was by sequential activation of Tpl-2/MEK/ERK/MSK1.	Serine	94-97	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	142-147
21274857-1	2011	Cyclooctatetraene in its dianionic form (COT(2-)) is considered to be partially or fully aromatic due to the fact that, unlike its neutral counterpart, it adopts planar structure with CC bonds equalized.	1,3,5,7-cyclooctatetraene	0-17	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	41-44
21428916-5	2011	PP2A similarly associates with the upstream regulator of MEK in this signalling pathway, TPL-2 (tumour progression locus-2), in response to arginine availability.	Arginine	140-148	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	89-94
19808894-9	2010	Importantly, Tpl2 was implicated in cytokine-induced lipolysis and in insulin receptor substrate-1 serine phosphorylation.	Serine	99-105	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	13-17
19808956-0	2009	Tpl2 is a key mediator of arsenite-induced signal transduction.	arsenite	26-34	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-4
19656169-4	2009	First appearance of cholesterol crystals in ultrafiltered bile (crystal observation time, COT) was studied with polarizing light microscopy during 21 days.	Cholesterol	20-31	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	90-93
19656169-5	2009	RESULTS: Patients with cholesterol stones had significantly shorter COT (3 days vs. >21 days, P < 0.05), higher CSI (149 +/- 10% vs. 97 +/- 7%, P < 0.05) and higher total biliary proteins (1.96 +/- 0.1 mg mL(-1) vs. 0.55 +/- 0.1 mg mL(-1), P < 0.05) than patients with pigment stones.	Cholesterol	23-34	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	68-71
19656169-9	2009	CONCLUSIONS: Biles with cholesterol stones show high CSI and total protein concentration, and rapid COT, which is even faster in patients with multiple stones and high protein concentration.	Cholesterol	24-35	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	100-103
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	208-212
19808956-3	2009	However, the relevance of Tpl2 in arsenite-induced carcinogenesis and the underlying mechanisms remain to be explored.	arsenite	34-42	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	26-30
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	208-212
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	Dinoprostone	97-103	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	17-21
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	47-55	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	22-26
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	Dinoprostone	85-91	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	22-26
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	Dinoprostone	97-103	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	145-153	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	137-141
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	Dinoprostone	97-103	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	17-21
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	182-190	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	182-190	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-7	2009	We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA.	arsenite	19-27	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	165-169
19808956-7	2009	We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA.	arsenite	19-27	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	190-194
19414798-5	2009	GAd activated the MAPKs MEK1/2 and ERK1/2 in macrophages via their upstream regulator Tpl2.	ganoderic acid D	0-3	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	86-90
19045028-0	2008	Photoelectron spectroscopic study of the anionic transition metalorganic complexes [Fe(1,2)(COT)](-) and [Co(COT)](-).	fe(1,2)	84-91	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	92-95
19159680-0	2009	Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.	Lithium	111-118	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	16-20
19159680-3	2009	We show here that in macrophages lithium stimulates Tpl2, a MAP kinase kinase kinase (MAP3K) known to mediate activation of extracellular signal regulated kinase (ERK) and the downstream target CREB.	Lithium	33-40	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	52-56
19159680-3	2009	We show here that in macrophages lithium stimulates Tpl2, a MAP kinase kinase kinase (MAP3K) known to mediate activation of extracellular signal regulated kinase (ERK) and the downstream target CREB.	Lithium	33-40	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	86-91
19159680-4	2009	Lithium activates Tpl2 by inducing degradation of p105, an NF-kappaB precursor protein that functions as a physiological inhibitor of Tpl2.	Lithium	0-7	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-22
19159680-4	2009	Lithium activates Tpl2 by inducing degradation of p105, an NF-kappaB precursor protein that functions as a physiological inhibitor of Tpl2.	Lithium	0-7	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	134-138
19159680-6	2009	Lithium also promotes the activation of Tpl2 and ERK by the TLR4 ligand LPS.	Lithium	0-7	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	40-44
19054068-3	2009	From a randomized RNA pool of hairpin ribozymes, using the systematic evolution of ligands by exponential enrichment, we have obtained an adenine-dependent hairpin ribozyme, Tpl2/Cot (tumour progression locus 2) ribozyme, which cleaves the Tpl2/Cot kinase mRNA sequence at nucleotides A225/G226 relative to the start codon of translation.	Adenine	138-145	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	174-178
19054068-3	2009	From a randomized RNA pool of hairpin ribozymes, using the systematic evolution of ligands by exponential enrichment, we have obtained an adenine-dependent hairpin ribozyme, Tpl2/Cot (tumour progression locus 2) ribozyme, which cleaves the Tpl2/Cot kinase mRNA sequence at nucleotides A225/G226 relative to the start codon of translation.	Adenine	138-145	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	179-182
19054068-3	2009	From a randomized RNA pool of hairpin ribozymes, using the systematic evolution of ligands by exponential enrichment, we have obtained an adenine-dependent hairpin ribozyme, Tpl2/Cot (tumour progression locus 2) ribozyme, which cleaves the Tpl2/Cot kinase mRNA sequence at nucleotides A225/G226 relative to the start codon of translation.	Adenine	138-145	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	240-244
19054068-3	2009	From a randomized RNA pool of hairpin ribozymes, using the systematic evolution of ligands by exponential enrichment, we have obtained an adenine-dependent hairpin ribozyme, Tpl2/Cot (tumour progression locus 2) ribozyme, which cleaves the Tpl2/Cot kinase mRNA sequence at nucleotides A225/G226 relative to the start codon of translation.	Adenine	138-145	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	245-248
19045028-1	2008	The gas-phase, iron and cobalt cyclooctatetraene cluster anions, [Fe(1,2)(COT)](-) and [Co(COT)](-), were generated using a laser vaporization source and studied using mass spectrometry and anion photoelectron spectroscopy.	fe(1,2)	66-73	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	74-77
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	ammonium ferrous sulfate	76-81	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	82-85
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	ammonium ferrous sulfate	76-81	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	82-85
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	Iron	65-67	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	68-71
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	ammonium ferrous sulfate	151-156	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	68-71
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	ammonium ferrous sulfate	151-156	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	82-85
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	ammonium ferrous sulfate	151-156	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	82-85
19045028-5	2008	Thus, the interaction of these transition metal, atomic and dimeric moieties with a COT molecule does not quench their magnetic moments, leading to the possibility that these combinations may be useful in forming novel magnetic materials.	Metals	42-47	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	84-87
18439422-3	2008	Cot expression induces p65 phosphorylation at serines 536 and 468 in dependence from its kinase function.	Serine	46-53	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-3
18572386-4	2008	Moreover, and in accordance with the increased Rac-GTP levels observed, Cot-T overexpressing cells develop more lamellipodia than control cells.	Guanosine Triphosphate	51-54	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	72-75
18572386-5	2008	Conversely, depletion of endogenous Cot increases the formation of stress fibers which is correlated with the high levels of Rho-GTP observed in these cells.	rho-gtp	125-132	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	36-39
17724252-4	2008	We show here that Cot can phosphorylate histone H3 at Ser-10 in vivo and in vitro, and that the phosphorylation of histone H3 at Ser-10 is required for Cot-induced cell transformation.	Serine	54-57	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-21
17724252-4	2008	We show here that Cot can phosphorylate histone H3 at Ser-10 in vivo and in vitro, and that the phosphorylation of histone H3 at Ser-10 is required for Cot-induced cell transformation.	Serine	129-132	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-21
17724252-4	2008	We show here that Cot can phosphorylate histone H3 at Ser-10 in vivo and in vitro, and that the phosphorylation of histone H3 at Ser-10 is required for Cot-induced cell transformation.	Serine	129-132	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	152-155
17709378-0	2007	Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.	Serine	28-34	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	19-24
17709378-4	2007	In wild-type macrophages, LPS induced the rapid phosphorylation of serine (S) 400 in the TPL-2 C-terminal tail.	Serine	67-73	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	89-94
17709378-5	2007	Mutation of this conserved residue to alanine (A) blocked the ability of retrovirally expressed TPL-2 to induce the activation of ERK in LPS-stimulated Nfkb1(-/-) macrophages.	Alanine	38-45	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	96-101
17703868-4	2007	We have constructed an adenine-dependent hairpin ribozyme that cleaves the sequence at nucleotides A(225)(downward arrow)G(226) relative to the start codon of translation of the Tpl-2 kinase mRNA; this serine/threonine kinase activates the mitogen-activated protein kinase pathway implicated in cell proliferation in breast cancer.	Adenine	23-30	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	178-183
17703868-8	2007	The resulting Tpl-2 ribozyme is active in cis cleavage: kinetic studies have been performed as a function of Mg2+ concentration, adenine concentration, as well as at different pH and with various cofactors.	magnesium ion	109-113	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	14-19
17703868-8	2007	The resulting Tpl-2 ribozyme is active in cis cleavage: kinetic studies have been performed as a function of Mg2+ concentration, adenine concentration, as well as at different pH and with various cofactors.	Adenine	129-136	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	14-19
17724252-6	2008	The formation of the Cot-c-fos promoter complex was also apparent when histone H3 was phosphorylated at Ser-10.	Serine	104-107	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	21-24
17724252-7	2008	Furthermore, the use of dominant negative mutants of histone H3 revealed that Cot was required for phosphorylation of histone H3 at Ser-10 to induce neoplastic cell transformation.	Serine	132-135	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	78-81
16973359-0	2006	Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.	quinoline-3-carbonitriles	55-80	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	14-18
17715908-0	2007	Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.	8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles	168-224	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	40-44
17715908-3	2007	Initial 4-anilino-6-aminoquinoline-3-carbonitrile leads showed poor selectivity for Tpl2 over epidermal growth factor receptor (EGFR) kinase.	SCHEMBL3468320	8-49	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	84-88
17206524-10	2007	The correlation above support that idea that the 3HC:COT ratio can be used as a predictor of CYP2A6 activity and nicotine clearance.	Nicotine	113-121	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	53-56
16973359-1	2006	The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described.	quinoline-3-carbonitriles	60-85	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	103-107
16087150-5	2005	COT prefers Mn(2+) to Mg(2+) as the ATP metal cofactor, exhibiting an unusually high ATP K(m) in the presence of Mg(2+).	Manganese(2+)	12-18	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-3
16797185-4	2006	Using several protein kinases as tests we found that amino-terminal fusion to maltose binding protein rescued expression of the poorly expressed human kinase Cot but had only a marginal effect on expression of a well-expressed kinase IKK-2.	Maltose	78-85	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	158-161
16165349-0	2005	Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.	1,7-naphthyridine-3-carbonitriles	56-89	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	14-18
16165349-1	2005	The synthesis and structure-activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described.	6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles	60-119	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	137-141
16087150-5	2005	COT prefers Mn(2+) to Mg(2+) as the ATP metal cofactor, exhibiting an unusually high ATP K(m) in the presence of Mg(2+).	magnesium ion	22-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-3
16087150-5	2005	COT prefers Mn(2+) to Mg(2+) as the ATP metal cofactor, exhibiting an unusually high ATP K(m) in the presence of Mg(2+).	Adenosine Triphosphate	36-39	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-3
16087150-5	2005	COT prefers Mn(2+) to Mg(2+) as the ATP metal cofactor, exhibiting an unusually high ATP K(m) in the presence of Mg(2+).	Adenosine Triphosphate	85-88	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-3
16087150-5	2005	COT prefers Mn(2+) to Mg(2+) as the ATP metal cofactor, exhibiting an unusually high ATP K(m) in the presence of Mg(2+).	magnesium ion	113-119	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-3
15778223-2	2005	Here we show that Tpl2 undergoes phosphorylation at Thr(290) both in cells overexpressing Tpl2 and in cells stimulated with lipopolysaccharide (LPS) or tumor necrosis factor-alpha and that phosphorylation on this site parallels Tpl2 activation.	Threonine	52-55	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-22
15778223-2	2005	Here we show that Tpl2 undergoes phosphorylation at Thr(290) both in cells overexpressing Tpl2 and in cells stimulated with lipopolysaccharide (LPS) or tumor necrosis factor-alpha and that phosphorylation on this site parallels Tpl2 activation.	Threonine	52-55	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	90-94
15778223-6	2005	We conclude that Tpl2 phosphorylation at Thr(290) is induced by LPS, depends on IKKbeta, and is required for the physiological activation of Tpl2 by external signals.	Threonine	41-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	141-145
15778223-2	2005	Here we show that Tpl2 undergoes phosphorylation at Thr(290) both in cells overexpressing Tpl2 and in cells stimulated with lipopolysaccharide (LPS) or tumor necrosis factor-alpha and that phosphorylation on this site parallels Tpl2 activation.	Threonine	52-55	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	90-94
15778223-3	2005	Reconstitution of Tpl2(-/-) macrophages with wild type Tpl2 or Tpl2 T290D restored ERK activation by LPS, whereas reconstitution of the same cells with Tpl2 T290A did not, suggesting that phosphorylation at Thr(290) is required for the physiological activation of Tpl2 by external signals.	Threonine	207-210	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-22
15778223-4	2005	Both the wild type Tpl2 and the kinase-inactive mutant Tpl2 K167M undergo Thr(290) phosphorylation, suggesting that Thr(290) may be a site of trans-phosphorylation rather than auto-phosphorylation.	Threonine	74-77	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	19-23
15778223-4	2005	Both the wild type Tpl2 and the kinase-inactive mutant Tpl2 K167M undergo Thr(290) phosphorylation, suggesting that Thr(290) may be a site of trans-phosphorylation rather than auto-phosphorylation.	Threonine	74-77	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	55-59
15778223-4	2005	Both the wild type Tpl2 and the kinase-inactive mutant Tpl2 K167M undergo Thr(290) phosphorylation, suggesting that Thr(290) may be a site of trans-phosphorylation rather than auto-phosphorylation.	Threonine	116-119	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	19-23
15778223-4	2005	Both the wild type Tpl2 and the kinase-inactive mutant Tpl2 K167M undergo Thr(290) phosphorylation, suggesting that Thr(290) may be a site of trans-phosphorylation rather than auto-phosphorylation.	Threonine	116-119	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	55-59
15778223-5	2005	Pretreatment of 293 cells and primary macrophages with the Ikappa-B kinase-beta (IKKbeta) inhibitor PS-1145 blocked Tpl2 phosphorylation at Thr(290), suggesting that phosphorylation depends on IKKbeta, an obligatory positive regulator of Tpl2.	PS1145	100-107	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	116-120
15778223-5	2005	Pretreatment of 293 cells and primary macrophages with the Ikappa-B kinase-beta (IKKbeta) inhibitor PS-1145 blocked Tpl2 phosphorylation at Thr(290), suggesting that phosphorylation depends on IKKbeta, an obligatory positive regulator of Tpl2.	PS1145	100-107	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	238-242
15778223-5	2005	Pretreatment of 293 cells and primary macrophages with the Ikappa-B kinase-beta (IKKbeta) inhibitor PS-1145 blocked Tpl2 phosphorylation at Thr(290), suggesting that phosphorylation depends on IKKbeta, an obligatory positive regulator of Tpl2.	Threonine	140-143	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	116-120
15778223-6	2005	We conclude that Tpl2 phosphorylation at Thr(290) is induced by LPS, depends on IKKbeta, and is required for the physiological activation of Tpl2 by external signals.	Threonine	41-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	17-21
15177570-2	2004	We found that a high proportion of these EST sequences contain 5"-end poly(dT) sequences that are remnants from the oligo(dT)-primed reverse transcription of polyadenylated mRNA templates used to generate EST cDNA for sequence clone libraries.	Poly T	70-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	41-44
15699325-9	2005	The results showed that lipopolysaccharide-induced Tpl2 phosphorylation at Thr-290 in macrophages promotes the release of Tpl2 from p105, contributes to the enzymatic activation of the Tpl2 kinase, and is required for the degradation of Tpl2 via the proteasome.	Threonine	75-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	122-126
15699325-9	2005	The results showed that lipopolysaccharide-induced Tpl2 phosphorylation at Thr-290 in macrophages promotes the release of Tpl2 from p105, contributes to the enzymatic activation of the Tpl2 kinase, and is required for the degradation of Tpl2 via the proteasome.	Threonine	75-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	122-126
15699325-0	2005	Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.	Threonine	19-22	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	37-41
15699325-0	2005	Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.	Threonine	19-22	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	73-77
15699325-6	2005	Recent studies revealed that Tpl2 undergoes phosphorylation at Thr-290 and that phosphorylation at this site is required for activation.	Threonine	63-66	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	29-33
15699325-9	2005	The results showed that lipopolysaccharide-induced Tpl2 phosphorylation at Thr-290 in macrophages promotes the release of Tpl2 from p105, contributes to the enzymatic activation of the Tpl2 kinase, and is required for the degradation of Tpl2 via the proteasome.	Threonine	75-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	51-55
15699325-9	2005	The results showed that lipopolysaccharide-induced Tpl2 phosphorylation at Thr-290 in macrophages promotes the release of Tpl2 from p105, contributes to the enzymatic activation of the Tpl2 kinase, and is required for the degradation of Tpl2 via the proteasome.	Threonine	75-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	122-126
15466476-0	2004	Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.	Threonine	19-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	59-63
15466476-0	2004	Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.	Threonine	19-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	64-67
15466476-4	2004	The Cot sequence contains a conserved threonine at position 290 in the activation loop of the kinase domain.	Threonine	38-47	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	4-7
15466476-6	2004	Thr-290 was also required for robust autophosphorylation of Cot.	Threonine	0-3	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	60-63
15466476-7	2004	Antibody generated to phospho-Thr-290-Cot recognized both wild-type and kinase-dead Cot, suggesting that phosphorylation of Thr-290 did not occur through autophosphorylation but via another kinase.	Threonine	30-33	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	38-41
15466476-7	2004	Antibody generated to phospho-Thr-290-Cot recognized both wild-type and kinase-dead Cot, suggesting that phosphorylation of Thr-290 did not occur through autophosphorylation but via another kinase.	Threonine	30-33	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	84-87
15466476-7	2004	Antibody generated to phospho-Thr-290-Cot recognized both wild-type and kinase-dead Cot, suggesting that phosphorylation of Thr-290 did not occur through autophosphorylation but via another kinase.	Threonine	124-127	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	38-41
15466476-7	2004	Antibody generated to phospho-Thr-290-Cot recognized both wild-type and kinase-dead Cot, suggesting that phosphorylation of Thr-290 did not occur through autophosphorylation but via another kinase.	Threonine	124-127	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	84-87
15466476-8	2004	We showed that Cot was constitutively phosphorylated at Thr-290 in transfected human embryonic kidney 293T cells as well as human monocytes as this residue was phosphorylated in unstimulated and lipopolysaccharide-stimulated cells to the same degree.	Threonine	56-59	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	15-18
15466476-9	2004	Treatment with herbimycin A inhibited Cot activity in the MEK/ERK pathway but did not inhibit phosphorylation at Thr-290.	herbimycin	15-27	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	38-41
15466476-10	2004	Together these results showed that phosphorylation of Cot at Thr-290 is necessary but not sufficient for full kinase activity in the MEK/ERK pathway.	Threonine	61-64	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	54-57
15325400-2	2004	The sleeping position of the infant significantly influenced bacterial population density of cot mattress polyurethane foams (p<0.0000001) and their covers (p<0.004).	Polyurethanes	106-118	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	93-96
15177570-2	2004	We found that a high proportion of these EST sequences contain 5"-end poly(dT) sequences that are remnants from the oligo(dT)-primed reverse transcription of polyadenylated mRNA templates used to generate EST cDNA for sequence clone libraries.	Poly T	70-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	205-208
12138205-7	2002	The regulation of NF-kappa B-dependent transcription by Cot requires Akt-dependent phosphorylation of serine 400 (S400), near the carboxy terminus of Cot.	Serine	102-108	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	56-59
15128824-4	2004	The TCR-induced pathway leading to serine 536 phosphorylation is regulated by the kinases Cot (Tpl2), receptor interacting protein, protein kinase Ctheta, and NF-kappaB-inducing kinase, but is independent from the phosphatidylinositol 3-kinase/Akt signaling pathway.	Serine	35-41	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	90-93
15128824-4	2004	The TCR-induced pathway leading to serine 536 phosphorylation is regulated by the kinases Cot (Tpl2), receptor interacting protein, protein kinase Ctheta, and NF-kappaB-inducing kinase, but is independent from the phosphatidylinositol 3-kinase/Akt signaling pathway.	Serine	35-41	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	95-99
12224965-2	2002	A study of the electrochemical behavior of cyclooctatetraene (COT) and nitrobenzene with Density Functional Theory and the conductor like solvation model (COSMO) is reported.	1,3,5,7-cyclooctatetraene	43-60	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	62-65
12224965-9	2002	Ion pairing of alkali metal counterions with the anionic reduction products gives rise to a negative contribution to DeltaDeltaE(disp) because the second ion-pairing step is more exothermic than the first, and the reduction of [KA] (A = COT, NB) is more exothermic than the reduction of A(-1).	Metals	22-27	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	237-240
12224965-9	2002	Ion pairing of alkali metal counterions with the anionic reduction products gives rise to a negative contribution to DeltaDeltaE(disp) because the second ion-pairing step is more exothermic than the first, and the reduction of [KA] (A = COT, NB) is more exothermic than the reduction of A(-1).	deltadeltae	117-128	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	237-240
12224965-11	2002	Nitrobenzene is treated with the same computational protocol to provide a system for comparison that is not complicated by the major structural change that influences the COT energy profile.	nitrobenzene	0-12	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	171-174
12138205-10	2002	This mutated form of Cot also acts as a dominant negative for T-cell antigen receptor/CD28- or Akt/phorbol myristate acetate-induced NF-kappa B induction, while having relatively little effect on tumor necrosis factor induction of NF-kappa B.	Tetradecanoylphorbol Acetate	99-124	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	21-24
9257820-6	1997	Truncated Cot expression also cooperates with PHA or phorbol 12,13-dibutyrate (PDBu) and calcium ionophore for IL-2 production in Jurkat cells.	Phorbol 12,13-Dibutyrate	53-77	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-13
10896655-4	2000	Activation of Jurkat T cells with either calcium ionophore or alphaCD3 and a phorbol ester increases the levels of the different COT transcripts.	Calcium	41-48	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	129-132
10896655-4	2000	Activation of Jurkat T cells with either calcium ionophore or alphaCD3 and a phorbol ester increases the levels of the different COT transcripts.	Phorbol Esters	77-90	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	129-132
11272558-0	2000	Electronic structure of [(CpCr)[(CO)3M]]mu-Cot (M = Cr, Fe): a theoretical study.	Chromium	28-30	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	43-46
11272558-0	2000	Electronic structure of [(CpCr)[(CO)3M]]mu-Cot (M = Cr, Fe): a theoretical study.	Iron	56-58	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	43-46
10771792-1	2000	The NOTT study showed improved survival in COT patients who received LTOT for longer periods (mean 17.7 h/d, median 19.4 h/d) from an ambulatory oxygen system, compared with the survival of NOT patients who received oxygen for a mean of 11.8 h/d from a stationary system.	Oxygen	145-151	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	43-46
9257820-6	1997	Truncated Cot expression also cooperates with PHA or phorbol 12,13-dibutyrate (PDBu) and calcium ionophore for IL-2 production in Jurkat cells.	Calcium	89-96	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-13
34478263-8	2021	Both c-di-GMP and LPS inductions of COX-2 expression in RAW macrophages are STING-independent and are regulated by Tpl2-MEK-ERK-CREB signaling; inhibitors of Tpl2, MEK, and ERK could attenuate COX-2 expression promoted by c-di-GMP.	bis(3',5')-cyclic diguanylic acid	5-13	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	115-119
8510223-9	1993	Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity.	carbonyl sulfide	35-38	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	162-167
8510223-9	1993	Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity.	gamma-32p	132-141	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	162-167
8510223-9	1993	Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity.	Adenosine Triphosphate	142-145	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	162-167
34478263-8	2021	Both c-di-GMP and LPS inductions of COX-2 expression in RAW macrophages are STING-independent and are regulated by Tpl2-MEK-ERK-CREB signaling; inhibitors of Tpl2, MEK, and ERK could attenuate COX-2 expression promoted by c-di-GMP.	bis(3',5')-cyclic diguanylic acid	5-13	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	158-162
34478263-8	2021	Both c-di-GMP and LPS inductions of COX-2 expression in RAW macrophages are STING-independent and are regulated by Tpl2-MEK-ERK-CREB signaling; inhibitors of Tpl2, MEK, and ERK could attenuate COX-2 expression promoted by c-di-GMP.	bis(3',5')-cyclic diguanylic acid	222-230	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	158-162
35051238-1	2022	Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that regulates the expression of inflammatory mediators in response to Toll-like receptors (TLR) and cytokine receptors.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-25
34567061-4	2021	Methods: Differential expression of MAP3K8 was determined by TIMER2.0, UALCAN, and Oncomine Platform.	oncomine	83-91	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	36-42
35051238-1	2022	Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that regulates the expression of inflammatory mediators in response to Toll-like receptors (TLR) and cytokine receptors.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
31760171-6	2020	A cytosolic serine/threonine protein kinase (Tpl2) modulates ATF-2-regulated effects on the endothelial cell cycle.	cholecystokinin C-terminal flanking peptide	12-18	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	45-49
33443087-4	2021	In this report, MAP3K8 mRNA levels were found decreased in the lungs of IPF patients and of mice upon bleomycin-induced pulmonary fibrosis.	Bleomycin	102-111	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	16-22
33361430-1	2020	Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the mitogen-activated protein 3 kinase (MAP3K) family, and it plays an important role in pathogen infection.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-25
33361430-1	2020	Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the mitogen-activated protein 3 kinase (MAP3K) family, and it plays an important role in pathogen infection.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
3301019-0	1987	Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases.	ethyl (+)-(2s,3s)-3-[(s)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate	31-129	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	131-134
429126-1	1979	The precipitation of calcium oxalates may involve transformation from a metastable hydrate such as calcium oxalate trihydrate, COT, to the thermodynamically stable monohydrate, COM.	Calcium Oxalate	21-37	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	127-130
429126-3	1979	After the initial dissolution of COT, the calcium concentration remains constant for prolonged periods while appreciable nucleation and growth of COM takes place concomitantly with COT dissolution.	Calcium	42-49	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	33-36
33082218-7	2021	Agreement between the predicted change in DeltaP with extracorporeal CO2 removal as computed using the measured ratio of alveolar dead space to tidal volume (VDalv/VT) or estimated VDalv/VT (VDalv,est/VT) was also evaluated.	Carbon Dioxide	69-72	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	191-203
33082218-10	2021	The predicted reduction in DeltaP with extracorporeal CO2 removal computed using VDalv,est/VT was in reasonable agreement with the expected reduction using VDalv/VT (bias -0.7 cm H2O, limits of agreement -1.87 to 0.47 cm H2O).	Carbon Dioxide	54-57	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	81-93
31760171-6	2020	A cytosolic serine/threonine protein kinase (Tpl2) modulates ATF-2-regulated effects on the endothelial cell cycle.	glycyl-threonine	19-28	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	45-49
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	Dinoprostone	345-349	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	179-183
31498175-3	2019	We recently reported recurrent fusion or truncation of the potentially targetable serine-threonine kinase gene MAP3K8 in 33% of Spitz melanomas.	Serine	82-88	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	111-117
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	pdac	231-235	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	152-177
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	Fatty Acids	377-387	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	152-177
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	pdac	231-235	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	179-183
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	Dinoprostone	327-343	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	152-177
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	Dinoprostone	327-343	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	179-183
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	Dinoprostone	345-349	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	152-177
31046874-5	2019	Mechanistic investigation of RAGE downstream in fibroblasts revealed a novel contribution of a mitogen-activated protein kinase kinase kinase (MAPKKK), tumor progression locus 2 (TPL2), which is required for positive regulation of PDAC cell motility through induction of cyclooxygenase 2 (COX2) and its catalyzed production of prostaglandin E2 (PGE2), a strong chemoattractive fatty acid.	Fatty Acids	377-387	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	179-183
30481266-0	2019	Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells.	Vemurafenib	67-78	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	31-37
30481266-10	2019	To confirm model prediction, we set a suitable in vitro experiment revealing that the treatment with MAP3K8 inhibitor restored the effect of vemurafenib in terms of both DNA fragmentation and poly (ADP-ribose) polymerase cleavage (apoptosis) in thyroid CSCs.	Vemurafenib	141-152	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	101-107
30481266-11	2019	Moreover, MAP3K8 expression levels may be a useful marker to predict the response to vemurafenib.	Vemurafenib	85-96	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-16
29485707-0	2018	Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-kappaB pathways in a model of chronic myeloid leukemia.	Imatinib Mesylate	36-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-22
30463908-7	2018	We identified MAPK kinase kinase 8 (MAP3K8) as a target gene of hypoxia-induced factor (HIF), a transcription factor controlled by oxygen tension, upstream of the p38/MAPK pathway.	Oxygen	131-137	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	36-42
30853309-1	2019	Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-25
30853309-1	2019	Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
30853309-1	2019	Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family.	Serine	38-44	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	82-87
30833747-0	2019	Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas.	spitzoid	96-104	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	86-92
29961775-1	2018	A new strategy to design new molecules based on a fused hydrocarbon ring system comprising a COT ring and two 5-membered rings has been proposed for the study of second order NLO properties.	Hydrocarbons	56-67	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	93-96
28193074-5	2016	HPLC-ICPMS analysis for cobalt (Co) and Cbl gave detection limits of 0.18 ng/g and 0.88 ng/g d.m.	Cobalt	24-30	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	32-34
28724746-9	2017	CONCLUSIONS: This study demonstrates that inhibiting the Nepsilon-(carboxymethyl)lysine-induced TPL2/ATF4/SDF1alpha axis can effectively prevent diabetes mellitus-mediated retinal microvascular dysfunction.	N(6)-carboxymethyllysine	66-87	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	96-100
28682606-2	2017	We employ simultaneous exposure of Cot molecules and Eu vapor in ultrahigh vacuum to an inert substrate, such as graphene.	Graphite	113-121	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	35-38
29229763-5	2018	Using an optimal peptide substrate based on this screen and a high-throughput mass spectrometry assay to monitor kinase activity, we found that the TPL-2 complex has significantly altered sensitivities versus existing ATP-competitive TPL-2 inhibitors than the isolated TPL-2 kinase domain.	Adenosine Triphosphate	218-221	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	148-153
29229763-5	2018	Using an optimal peptide substrate based on this screen and a high-throughput mass spectrometry assay to monitor kinase activity, we found that the TPL-2 complex has significantly altered sensitivities versus existing ATP-competitive TPL-2 inhibitors than the isolated TPL-2 kinase domain.	Adenosine Triphosphate	218-221	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	234-239
29229763-5	2018	Using an optimal peptide substrate based on this screen and a high-throughput mass spectrometry assay to monitor kinase activity, we found that the TPL-2 complex has significantly altered sensitivities versus existing ATP-competitive TPL-2 inhibitors than the isolated TPL-2 kinase domain.	Adenosine Triphosphate	218-221	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	234-239
29229763-6	2018	These results imply that screens with the more physiologically relevant TPL-2/NF-kappaB1 p105/ABIN-2 complex have the potential to deliver novel TPL-2 chemical series; both ATP-competitive and allosteric inhibitors could emerge with significantly improved prospects for development as anti-inflammatory drugs.	Adenosine Triphosphate	173-176	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	72-77
29229763-6	2018	These results imply that screens with the more physiologically relevant TPL-2/NF-kappaB1 p105/ABIN-2 complex have the potential to deliver novel TPL-2 chemical series; both ATP-competitive and allosteric inhibitors could emerge with significantly improved prospects for development as anti-inflammatory drugs.	Adenosine Triphosphate	173-176	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	145-150
27381428-2	2016	These complexes contain the large flat cyclooctatetraenyl ligand (C8H8(2-), commonly abbreviated as COT), and were isolated as solvated, unsolvated and inverse sandwich complexes.	c8h8	66-70	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	100-103
27751847-0	2016	Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study.	osimertinib	0-11	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	88-93
27381428-10	2016	A unique multidecker sandwich complex [(mu-eta(8):eta(8)-COT){Nd(c-C3H5-C[triple bond, length as m-dash]C-C(NCy)2)(mu-Cl)}2]4 (15) was prepared by reaction of anhydrous NdCl3 with K2COT and 1b in a one-pot reaction.	c3h5	67-71	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	57-60
27381428-6	2016	Novel unsolvated dinuclear lanthanide half-sandwich complexes were prepared by using the precursors 1a, 1b and COT(2-).	Lanthanoid Series Elements	27-37	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	111-114
27381428-10	2016	A unique multidecker sandwich complex [(mu-eta(8):eta(8)-COT){Nd(c-C3H5-C[triple bond, length as m-dash]C-C(NCy)2)(mu-Cl)}2]4 (15) was prepared by reaction of anhydrous NdCl3 with K2COT and 1b in a one-pot reaction.	mu-cl	115-120	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	57-60
27381428-7	2016	Unlike the complexes 2-4, the reaction of [(COT)Pr(mu-Cl)(THF)2]2 with 1a afforded the unsolvated centrosymmetric complex [(COT)Pr(mu-c-C3H5-C[triple bond, length as m-dash]C-C(N(i)Pr)2)]2 (9).	mu-cl	51-56	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	44-47
27381428-7	2016	Unlike the complexes 2-4, the reaction of [(COT)Pr(mu-Cl)(THF)2]2 with 1a afforded the unsolvated centrosymmetric complex [(COT)Pr(mu-c-C3H5-C[triple bond, length as m-dash]C-C(N(i)Pr)2)]2 (9).	mu-cl	51-56	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	124-127
27381428-10	2016	A unique multidecker sandwich complex [(mu-eta(8):eta(8)-COT){Nd(c-C3H5-C[triple bond, length as m-dash]C-C(NCy)2)(mu-Cl)}2]4 (15) was prepared by reaction of anhydrous NdCl3 with K2COT and 1b in a one-pot reaction.	neodymium chloride	169-174	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	57-60
27381428-7	2016	Unlike the complexes 2-4, the reaction of [(COT)Pr(mu-Cl)(THF)2]2 with 1a afforded the unsolvated centrosymmetric complex [(COT)Pr(mu-c-C3H5-C[triple bond, length as m-dash]C-C(N(i)Pr)2)]2 (9).	tetrahydrofuran	58-61	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	44-47
27381428-7	2016	Unlike the complexes 2-4, the reaction of [(COT)Pr(mu-Cl)(THF)2]2 with 1a afforded the unsolvated centrosymmetric complex [(COT)Pr(mu-c-C3H5-C[triple bond, length as m-dash]C-C(N(i)Pr)2)]2 (9).	tetrahydrofuran	58-61	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	124-127
27381428-7	2016	Unlike the complexes 2-4, the reaction of [(COT)Pr(mu-Cl)(THF)2]2 with 1a afforded the unsolvated centrosymmetric complex [(COT)Pr(mu-c-C3H5-C[triple bond, length as m-dash]C-C(N(i)Pr)2)]2 (9).	Carbon	44-45	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	124-127
27381428-9	2016	Similar treatment of HoCl3 with 1a or 1b and K2COT as three-component reactions in a 1 : 1 : 1 molar ratio afforded the solvated half-sandwich complexes (COT)Ho(c-C3H5-C[triple bond, length as m-dash]C-C(NR)2)(THF) (13: R = (i)Pr; 14: R = Cy).	hocl3	21-26	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	47-50
27381428-9	2016	Similar treatment of HoCl3 with 1a or 1b and K2COT as three-component reactions in a 1 : 1 : 1 molar ratio afforded the solvated half-sandwich complexes (COT)Ho(c-C3H5-C[triple bond, length as m-dash]C-C(NR)2)(THF) (13: R = (i)Pr; 14: R = Cy).	Carbon	23-24	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	47-50
27381428-9	2016	Similar treatment of HoCl3 with 1a or 1b and K2COT as three-component reactions in a 1 : 1 : 1 molar ratio afforded the solvated half-sandwich complexes (COT)Ho(c-C3H5-C[triple bond, length as m-dash]C-C(NR)2)(THF) (13: R = (i)Pr; 14: R = Cy).	tetrahydrofuran	210-213	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	47-50
27381428-9	2016	Similar treatment of HoCl3 with 1a or 1b and K2COT as three-component reactions in a 1 : 1 : 1 molar ratio afforded the solvated half-sandwich complexes (COT)Ho(c-C3H5-C[triple bond, length as m-dash]C-C(NR)2)(THF) (13: R = (i)Pr; 14: R = Cy).	Cyclophosphamide	239-241	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	47-50
27381428-10	2016	A unique multidecker sandwich complex [(mu-eta(8):eta(8)-COT){Nd(c-C3H5-C[triple bond, length as m-dash]C-C(NCy)2)(mu-Cl)}2]4 (15) was prepared by reaction of anhydrous NdCl3 with K2COT and 1b in a one-pot reaction.	Carbon	16-17	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	57-60
27259980-6	2016	We show that versikine signals through pathways both dependent and independent of Tpl2 kinase, a key regulator of nuclear factor kappaB1-mediated MAPK activation in macrophages.	versikine	13-22	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	82-86
27502541-0	2016	Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors.	imidazoquinolines	13-30	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	116-119
27261457-12	2016	Overall, these findings suggest that Tpl2 inhibition could be used to preferentially drive Treg induction and thereby limit inflammation in a variety of autoimmune diseases.	treg	91-95	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	37-41
27001999-0	2016	Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8.	Estradiol	107-117	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	141-147
27275599-1	2016	OBJECTIVE: We have previously demonstrated that a mixture of curcuminoids extract, hydrolyzed collagen and green tea extract (COT) inhibited inflammatory and catabolic mediator"s synthesis by osteoarthritic human chondrocytes.	curcuminoids	61-73	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	126-129
27001999-10	2016	In addition, miRNA-509-3p mimics or inhibitor transfection tests in KGN cells further confirmed that miRNA-509-3p improved oestradiol (E2) secretion by inhibiting the expression of MAP3K8 These results help to characterise the pathogenesis of anovulation in PCOS, especially the regulation of E2 production.	Estradiol	123-133	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	181-187
27069140-9	2016	The efficacy of MAP3K8 inhibition in our model potentially uncovers a new mechanism to circumvent 5-FU resistance.	Fluorouracil	98-102	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	16-22
26792743-5	2016	Furthermore, cmvIL-10 upregulated expression of tumor progression locus 2 (TPL2), which is a regulator of the positive hIL-10 feedback loop, whereas expression of a negative regulator of the hIL-10 feedback loop, dual-specificity phosphatase 1 (DUSP1), remained unchanged.	cmvil-10	13-21	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	48-73
26792743-5	2016	Furthermore, cmvIL-10 upregulated expression of tumor progression locus 2 (TPL2), which is a regulator of the positive hIL-10 feedback loop, whereas expression of a negative regulator of the hIL-10 feedback loop, dual-specificity phosphatase 1 (DUSP1), remained unchanged.	cmvil-10	13-21	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	75-79
24998852-3	2015	We demonstrate that TPL2 mediates the phosphorylation of a fraction of NPM at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state NPM levels.	Threonine	78-87	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	20-24
24998852-6	2015	These findings expand our understanding of the function of TPL2 as a negative regulator of carcinogenesis by defining a nuclear role for this kinase in the topological sequestration of NPM, linking p53 signaling to the generation of threonine 199-phosphorylated NPM.	Threonine	233-242	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	59-63
26300007-8	2016	Mechanistic studies indicate that p105/Tpl2 signaling is required for suppressing urethane-induced lung damage and inflammation, and activating mutations of the K-Ras oncogene.	Urethane	82-90	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	39-43
25617073-0	2015	Comparison of antibiotic prophylaxis with cotrimoxazole/colistin (COT/COL) versus ciprofloxacin (CIP) in patients with acute myeloid leukemia.	Trimethoprim, Sulfamethoxazole Drug Combination	42-55	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	66-73
25617073-3	2015	Thus, in April 2008, we changed our antibiotic prophylaxis regimen from cotrimoxazole/colistin (COT/COL) to the fluoroquinolone ciprofloxacin (CIP) in patients with acute myeloid leukemia (AML).	Trimethoprim, Sulfamethoxazole Drug Combination	72-85	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	96-103
25674762-4	2015	Datasets from public repository (NCBI) were subjected to Gene Set Enrichment Analysis (GSEA).qPCR data showed that the relative mRNA expression of A-, B-, C-RAF and COT of PTC were higher than normal tissues (all P < 0.01).	gsea	87-91	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	165-168