PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 31915781-4 2020 1H NMR spectra of 1,1-dinitroethane solution at room temperature in various solvents (carbon tetrachloride, chloroform, dichloromethane, acetone, dimethylformamide and dimethyl sulfoxide) illustrate the increase of 1JCH by several Hz upon an increase of the complex strength. amphetaminil 18-35 joining chain of multimeric IgA and IgM Homo sapiens 216-219 33737336-8 2021 Patients with low IGJ had a 7.2-fold (p<0.001) increase in risk of disease-specific death with a median DSS of 13 months. dss 104-107 joining chain of multimeric IgA and IgM Homo sapiens 18-21 33737336-9 2021 Low IGJ showed an area under curve (AUC) of 0.89 with 91.0% sensitivity and 87.6% specificity to identify early disease-specific mortality (defined as DSS <=12 months). dss 151-154 joining chain of multimeric IgA and IgM Homo sapiens 4-7 31915781-5 2020 Computational results (MP2/aug-cc-pVDZ) reproduce this observation and allow one to conclude that the increase of 1JCH is mainly caused by the change of the carbon hybridization (an increase of s-character), rather than by the change in interatomic distance rCH. Carbon 157-163 joining chain of multimeric IgA and IgM Homo sapiens 115-118 31915781-6 2020 The behavior of 1JCH was also examined computationally for a wide range of CHX hydrogen bond energies and geometries. N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid 75-87 joining chain of multimeric IgA and IgM Homo sapiens 17-20 27038031-3 2016 IgM can exist as a pentamer with a connecting singly N-glycosylated J-chain (with a total of 51 glycosylation sites) or as a hexamer (60 glycosylation sites). Nitrogen 53-54 joining chain of multimeric IgA and IgM Homo sapiens 68-75 30101591-1 2018 Unusual 1 JCH values for an oxocane derivative were recently reported, highlighting the unexpected long-range Perlin effect for the 1 JCH. OXOCANE 28-35 joining chain of multimeric IgA and IgM Homo sapiens 10-13 30101591-1 2018 Unusual 1 JCH values for an oxocane derivative were recently reported, highlighting the unexpected long-range Perlin effect for the 1 JCH. OXOCANE 28-35 joining chain of multimeric IgA and IgM Homo sapiens 134-137 29168914-1 2018 Unprecedented scatter plots of calculated versus measured NMR 2,3 JCH coupling constants in six densely oxygen functionalized epoxides are found with some B3LYP protocols, an effect attributed to stereoelectronic effects. Oxygen 104-110 joining chain of multimeric IgA and IgM Homo sapiens 66-69 29168914-1 2018 Unprecedented scatter plots of calculated versus measured NMR 2,3 JCH coupling constants in six densely oxygen functionalized epoxides are found with some B3LYP protocols, an effect attributed to stereoelectronic effects. Epoxy Compounds 126-134 joining chain of multimeric IgA and IgM Homo sapiens 66-69 28550167-3 2017 We verified a triple-marker panel to be predictive of the response to sorafenib by MRM-MS, comprising CD5 antigen-like (CD5L), immunoglobulin J (IGJ), and galectin-3-binding protein (LGALS3BP), in HCC patients. Sorafenib 70-79 joining chain of multimeric IgA and IgM Homo sapiens 127-143 28550167-3 2017 We verified a triple-marker panel to be predictive of the response to sorafenib by MRM-MS, comprising CD5 antigen-like (CD5L), immunoglobulin J (IGJ), and galectin-3-binding protein (LGALS3BP), in HCC patients. Sorafenib 70-79 joining chain of multimeric IgA and IgM Homo sapiens 145-148 28092787-0 2017 Perfect 1JCH-resolved HSQC: Efficient measurement of one-bond proton-carbon coupling constants along the indirect dimension. Carbon 69-75 joining chain of multimeric IgA and IgM Homo sapiens 9-12 31066094-1 2019 The experimental and theoretical behavior of the (O C) C C H 3 JCH coupling constant is investigated for a series of alpha,beta-unsaturated compounds (1 to 8), and for some of them, the well-known relationship (3 JCHcis < 3 JCHtrans ) was observed. alpha,beta-unsaturated compounds 117-149 joining chain of multimeric IgA and IgM Homo sapiens 63-66 31066094-4 2019 Taking all of these in consideration, a new Karplus-type equation was proposed for 3 JCH couplings in alpha,beta-unsaturated compounds, which can be used for configurational and conformational assignment on trisubstituted double bond derivatives. unsaturated 113-124 joining chain of multimeric IgA and IgM Homo sapiens 85-88 27720845-5 2016 A discovery/validation study on RR-MS responsive to glatiramer acetate identified 8 differentially expressed genes: ITGA2B, ITGB3, CD177, IGJ, IL5RA, MMP8, P2RY12, and S100beta. Glatiramer Acetate 52-70 joining chain of multimeric IgA and IgM Homo sapiens 138-141 23727458-4 2013 The attenuation of IgM secretion by Delta(9)-THC involved, at least in part, the impairment of plasma cell differentiation as evidenced by suppression of immunoglobulin joining chain (IgJ) mRNA expression. Dronabinol 36-48 joining chain of multimeric IgA and IgM Homo sapiens 154-182 26749401-0 2016 Conformation analysis of d-glucaric acid in deuterium oxide by NMR based on its JHH and JCH coupling constants. Glucaric Acid 25-40 joining chain of multimeric IgA and IgM Homo sapiens 88-91 26749401-0 2016 Conformation analysis of d-glucaric acid in deuterium oxide by NMR based on its JHH and JCH coupling constants. Deuterium Oxide 44-59 joining chain of multimeric IgA and IgM Homo sapiens 88-91 26749401-2 2016 The purpose of this study was to conduct a conformation analysis of flexible GA as a solution in deuterium oxide by NMR spectroscopy, based on J-resolved conformation analysis using proton-proton ((3) JHH ) and proton-carbon ((2) JCH and (3) JCH ) coupling constants, as well as nuclear overhauser effect spectroscopy (NOESY). Deuterium Oxide 97-112 joining chain of multimeric IgA and IgM Homo sapiens 230-233 26749401-2 2016 The purpose of this study was to conduct a conformation analysis of flexible GA as a solution in deuterium oxide by NMR spectroscopy, based on J-resolved conformation analysis using proton-proton ((3) JHH ) and proton-carbon ((2) JCH and (3) JCH ) coupling constants, as well as nuclear overhauser effect spectroscopy (NOESY). Deuterium Oxide 97-112 joining chain of multimeric IgA and IgM Homo sapiens 242-245 26741055-2 2016 Utilization of [1"-(13)C]-site-specific labeling in the anomeric position at the glycosidic linkage between the two sugar residues facilitated the determination of transglycosidic NMR (3)JCH and (3)JCC coupling constants. Sugars 116-121 joining chain of multimeric IgA and IgM Homo sapiens 187-190 23967082-2 2013 We identified a J chain in dipnoid fish, the African lungfish (Protopterus dolloi) by high throughput sequencing of the transcriptome. dipnoid 27-34 joining chain of multimeric IgA and IgM Homo sapiens 16-23 23967082-3 2013 P. dolloi J chain is 161 aa long and contains six of the eight Cys residues present in mammalian J chain. Cysteine 63-66 joining chain of multimeric IgA and IgM Homo sapiens 10-17 23967082-3 2013 P. dolloi J chain is 161 aa long and contains six of the eight Cys residues present in mammalian J chain. Cysteine 63-66 joining chain of multimeric IgA and IgM Homo sapiens 97-104 23727458-4 2013 The attenuation of IgM secretion by Delta(9)-THC involved, at least in part, the impairment of plasma cell differentiation as evidenced by suppression of immunoglobulin joining chain (IgJ) mRNA expression. Dronabinol 36-48 joining chain of multimeric IgA and IgM Homo sapiens 184-187 18948302-5 2009 mRNA levels of the IgM components, immunoglobulin kappa light chain, immunoglobulin mu heavy chain, and immunoglobulin J-chain were significantly decreased by TCDD treatment, an effect that was completely reversed by IFN-gamma (100 U/ml) cotreatment. Polychlorinated Dibenzodioxins 159-163 joining chain of multimeric IgA and IgM Homo sapiens 104-126 21212016-4 2011 Furthermore, this is the first time the results of the calculated JCH and JCC coupling constants of the C10H10O4 molecule are presented in this study. c10h10o4 104-112 joining chain of multimeric IgA and IgM Homo sapiens 66-69 23962883-1 2013 A general review of novel NMR methods to measure heteronuclear long-range proton-carbon coupling constants ((n)JCH; n>1) in small molecules is made. Carbon 81-87 joining chain of multimeric IgA and IgM Homo sapiens 111-114 18950144-0 2008 Analysis of the electronic origin of the 1JCH spin-spin coupling trend in 1-X-cyclopropanes: experimental and DFT study. 1-x-cyclopropanes 74-91 joining chain of multimeric IgA and IgM Homo sapiens 42-45 18669274-6 2008 The J-chain is inserted into the sIgA and sIgM molecules to form disulfide bonds with C-terminal sites of alpha- or mu-chains. Disulfides 65-74 joining chain of multimeric IgA and IgM Homo sapiens 4-11 18181244-1 2008 3JCH couplings in alpha-substituted acetamides. alpha-substituted acetamides 18-46 joining chain of multimeric IgA and IgM Homo sapiens 1-4 17534878-0 2007 Experimental and DFT studies on the transmission mechanisms of analogous NMR JCH and JCC couplings in 1-X- and 1-X-3-methylbicyclo[1.1.1]-pentanes. 1-x- and 1-x-3-methylbicyclo[1 102-132 joining chain of multimeric IgA and IgM Homo sapiens 77-80 18092306-0 2008 The effect of carbonyl group in the asymmetry of 3,4JCH coupling constants in norbornanones. norbornanones 78-91 joining chain of multimeric IgA and IgM Homo sapiens 52-55 18044806-0 2007 J(F,H), J(C,H) and J(H,H) couplings involving the individual methyl group protons in 1,2,3,4-tetrachloro-5,6,7,8-tetrafluoro-9-methyltriptycene. 1,2,3,4-tetrachloro-5,6,7,8-tetrafluoro-9-methyltriptycene 85-143 joining chain of multimeric IgA and IgM Homo sapiens 8-13 17534878-0 2007 Experimental and DFT studies on the transmission mechanisms of analogous NMR JCH and JCC couplings in 1-X- and 1-X-3-methylbicyclo[1.1.1]-pentanes. Pentanes 138-146 joining chain of multimeric IgA and IgM Homo sapiens 77-80 17048264-0 2007 Long-range JCH heteronuclear coupling constants in cyclopentane derivatives. Cyclopentanes 51-63 joining chain of multimeric IgA and IgM Homo sapiens 11-14 16941579-0 2006 Halogen - metal exchange of 3-substituted 1,2-dibromoarenes: the use of long-range JCH coupling constants to determine regiochemistry. Halogens 0-7 joining chain of multimeric IgA and IgM Homo sapiens 83-86 16941579-0 2006 Halogen - metal exchange of 3-substituted 1,2-dibromoarenes: the use of long-range JCH coupling constants to determine regiochemistry. 3-substituted 1,2-dibromoarenes 28-59 joining chain of multimeric IgA and IgM Homo sapiens 83-86 17065740-2 2006 Based on its amino acid and gene sequences data, disulfide bond (2 bonds) assignment secondary structure predictions, and chemical properties, a model for J-chain folding has been proposed. Disulfides 49-58 joining chain of multimeric IgA and IgM Homo sapiens 155-162 17065740-3 2006 However, the crystal structure of the J-chain protein is still far from obtained, because the J-chain expression and its protein downstream has a permanent aggregation problems, due to its two free thiol groups. Sulfhydryl Compounds 198-203 joining chain of multimeric IgA and IgM Homo sapiens 38-45 17065740-3 2006 However, the crystal structure of the J-chain protein is still far from obtained, because the J-chain expression and its protein downstream has a permanent aggregation problems, due to its two free thiol groups. Sulfhydryl Compounds 198-203 joining chain of multimeric IgA and IgM Homo sapiens 94-101 17065740-6 2006 While mutate the cysteines into serine has been yielded a complete soluble (11.5 mg/l) J-chain protein which migrate (SDS-PAGE) at 27 KDa. Cysteine 17-26 joining chain of multimeric IgA and IgM Homo sapiens 87-94 17065740-6 2006 While mutate the cysteines into serine has been yielded a complete soluble (11.5 mg/l) J-chain protein which migrate (SDS-PAGE) at 27 KDa. Serine 32-38 joining chain of multimeric IgA and IgM Homo sapiens 87-94 17065740-6 2006 While mutate the cysteines into serine has been yielded a complete soluble (11.5 mg/l) J-chain protein which migrate (SDS-PAGE) at 27 KDa. Sodium Dodecyl Sulfate 118-121 joining chain of multimeric IgA and IgM Homo sapiens 87-94 14511591-1 2003 A new pulse sequence, long-range CPMG-adjusted heteronuclear single quantum coherence (LR-CAHSQC), is proposed for the determination of long-range JCH coupling constants from a long-range 1H-13C correlation experiment. Hydrogen 188-190 joining chain of multimeric IgA and IgM Homo sapiens 147-150 15294089-5 2004 Analysis of glycosylation status of the J-chain in the transfectant was examined by tunicamycin treatment, endoglycosidase H digestion, and also by treatment with brefeldin A. Tunicamycin 84-95 joining chain of multimeric IgA and IgM Homo sapiens 40-47 15294089-5 2004 Analysis of glycosylation status of the J-chain in the transfectant was examined by tunicamycin treatment, endoglycosidase H digestion, and also by treatment with brefeldin A. Brefeldin A 163-174 joining chain of multimeric IgA and IgM Homo sapiens 40-47 15294089-6 2004 It was found that an N-glycosylation consensus site of the J-chain was functional, and intracellular J-chain was endoglycosidase H sensitive. Nitrogen 21-22 joining chain of multimeric IgA and IgM Homo sapiens 59-66 15294089-9 2004 Cultivation of the J-chain transfectant in the presence of ionomycin resulted in the time-dependent secretion of the J-chain. Ionomycin 59-68 joining chain of multimeric IgA and IgM Homo sapiens 19-26 15294089-9 2004 Cultivation of the J-chain transfectant in the presence of ionomycin resulted in the time-dependent secretion of the J-chain. Ionomycin 59-68 joining chain of multimeric IgA and IgM Homo sapiens 117-124 14511591-1 2003 A new pulse sequence, long-range CPMG-adjusted heteronuclear single quantum coherence (LR-CAHSQC), is proposed for the determination of long-range JCH coupling constants from a long-range 1H-13C correlation experiment. 13c 191-194 joining chain of multimeric IgA and IgM Homo sapiens 147-150 12794129-6 2003 Of the eight half-cystine residues that are conserved in mammalian J chains, three are lacking in the nurse shark, including two in the carboxyl-terminal segment that have been reported to be required for binding of human J chain-containing IgA to secretory component. Cystine 18-25 joining chain of multimeric IgA and IgM Homo sapiens 67-74 9488050-3 1997 J chain in several mammalian species (human, mouse, cow and rabbit) has eight Cys residues. Cysteine 78-81 joining chain of multimeric IgA and IgM Homo sapiens 0-7 11053033-1 2000 Triptolide (PG490, 97% pure) is a diterpenoid triepoxide with potent anti-inflammatory and immunosuppressive effects in transformed human bronchial epithelial cells and T cells (Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC-H, and Kao PN. triptolide 0-10 joining chain of multimeric IgA and IgM Homo sapiens 231-235 11673531-3 2001 The J chain is critical in the structure of SIgA because it is required for efficient polymerization of IgA and for the affinity of such polymers to the secretory component (SC)/polymeric (p)IgR. Polymers 137-145 joining chain of multimeric IgA and IgM Homo sapiens 4-11 9244345-4 1997 To determine the mechanism by which J chain regulates the assembly process, we defined the point at which J chain is added to assembling polymers. Polymers 137-145 joining chain of multimeric IgA and IgM Homo sapiens 36-43 9244345-4 1997 To determine the mechanism by which J chain regulates the assembly process, we defined the point at which J chain is added to assembling polymers. Polymers 137-145 joining chain of multimeric IgA and IgM Homo sapiens 106-113 8168154-2 1993 With this technique, we have been able to detect expression of J chain and mu chain in a single 6-10-microns-thick formalin-fixed paraffin-embedded section of fetal liver tissue. Formaldehyde 115-123 joining chain of multimeric IgA and IgM Homo sapiens 63-83 7708742-0 1995 Polymer IgM assembly and secretion in lymphoid and nonlymphoid cell lines: evidence that J chain is required for pentamer IgM synthesis. Polymers 0-7 joining chain of multimeric IgA and IgM Homo sapiens 89-96 8724136-3 1996 Interpretation of 3JCH data for a pentasaccharide (lacto-N-fuco-pentaose 2) from human milk are consistent with a rigid model for the Lewis(a) trisaccharide epitope but for an antigenic tetrasaccharide fragment from the cell wall polysaccharide of viridans streptococci, 3JCH data imply a considerably more flexible model. pentasaccharide 34-49 joining chain of multimeric IgA and IgM Homo sapiens 19-22 8168154-2 1993 With this technique, we have been able to detect expression of J chain and mu chain in a single 6-10-microns-thick formalin-fixed paraffin-embedded section of fetal liver tissue. Paraffin 130-138 joining chain of multimeric IgA and IgM Homo sapiens 63-83 1472500-0 1992 Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. The assignment of disulfide bonds in human J chain and its covalent pairing with immunoglobulin M was determined under conditions which minimize disulfide bond interchange. Disulfides 0-9 joining chain of multimeric IgA and IgM Homo sapiens 35-42 1472500-0 1992 Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. The assignment of disulfide bonds in human J chain and its covalent pairing with immunoglobulin M was determined under conditions which minimize disulfide bond interchange. Disulfides 0-9 joining chain of multimeric IgA and IgM Homo sapiens 134-141 1472500-1 1992 We show that in J chain the three intradisulfide bridges are formed between Cys 12 and 100, Cys 71 and 91, and Cys 108 and 133. intradisulfide 34-48 joining chain of multimeric IgA and IgM Homo sapiens 16-23 1472500-0 1992 Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. The assignment of disulfide bonds in human J chain and its covalent pairing with immunoglobulin M was determined under conditions which minimize disulfide bond interchange. Disulfides 109-118 joining chain of multimeric IgA and IgM Homo sapiens 35-42 1472500-1 1992 We show that in J chain the three intradisulfide bridges are formed between Cys 12 and 100, Cys 71 and 91, and Cys 108 and 133. Cysteine 76-79 joining chain of multimeric IgA and IgM Homo sapiens 16-23 1472500-1 1992 We show that in J chain the three intradisulfide bridges are formed between Cys 12 and 100, Cys 71 and 91, and Cys 108 and 133. Cysteine 92-95 joining chain of multimeric IgA and IgM Homo sapiens 16-23 1472500-1 1992 We show that in J chain the three intradisulfide bridges are formed between Cys 12 and 100, Cys 71 and 91, and Cys 108 and 133. Cysteine 92-95 joining chain of multimeric IgA and IgM Homo sapiens 16-23 1472500-7 1992 A revised, albeit putative, model of J chain folding is presented which takes into account the correct disulfide pairing and the predictive secondary structure assignment. Disulfides 103-112 joining chain of multimeric IgA and IgM Homo sapiens 37-44 1472500-0 1992 Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. The assignment of disulfide bonds in human J chain and its covalent pairing with immunoglobulin M was determined under conditions which minimize disulfide bond interchange. Disulfides 109-118 joining chain of multimeric IgA and IgM Homo sapiens 134-141 2174785-4 1990 Analysis of one of the monoclonal antibodies by sucrose gradient centrifugation showed that the J chain-deficient form sedimented faster than the complete IgM. Sucrose 48-55 joining chain of multimeric IgA and IgM Homo sapiens 96-103 2174785-5 1990 It is known that IgM preparations lacking J chain sediment faster by sucrose gradient centrifugation analysis and tend to form hexamers. Sucrose 69-76 joining chain of multimeric IgA and IgM Homo sapiens 42-49 34428184-5 2021 Naturally assembled dimeric IgA, also known as secretory IgA, involves a J-chain subunit connected with two IgA1 molecules via their penultimate cysteine-471 residue on "tailpiece" segment of IgA heavy chain. Cysteine 145-153 joining chain of multimeric IgA and IgM Homo sapiens 73-80 3115821-6 1987 The IgM cells in PMG, where J chain is present in a disulfide-linked form, had no or few J+ nucleoli. Disulfides 52-61 joining chain of multimeric IgA and IgM Homo sapiens 28-35 3111987-4 1987 The deficiency of J-chain (estimated to be less than 0.17% of normal) was shown by alkaline-urea overloaded gel electrophoresis followed by silver staining. Urea 92-96 joining chain of multimeric IgA and IgM Homo sapiens 18-25 3111987-4 1987 The deficiency of J-chain (estimated to be less than 0.17% of normal) was shown by alkaline-urea overloaded gel electrophoresis followed by silver staining. Silver 140-146 joining chain of multimeric IgA and IgM Homo sapiens 18-25 6421307-4 1984 All fifteen patients with papillary IgA deposits and all four with GL IgA deposits had J-chain staining coextensive with the IgA. gl 67-69 joining chain of multimeric IgA and IgM Homo sapiens 87-94 3929074-1 1985 A J-chain was found in the IgM, an 18-S pentameric immunoglobulin, of the skate, Raja kenojei, a cartilaginous fish, by means of gel filtration-column chromatography of reduced and radioalkylated immunoglobulin, followed by alkaline-urea polyacrylamide gel electrophoresis. alkaline-urea polyacrylamide 224-252 joining chain of multimeric IgA and IgM Homo sapiens 2-9 6441159-10 1984 J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0). Ethanol 69-76 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6441159-10 1984 J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0). acid urea 103-112 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6441159-10 1984 J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0). Formaldehyde 178-186 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6441159-10 1984 J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0). acetic acid-formol saline 188-213 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6441159-10 1984 J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0). Bouin's solution 215-228 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6441159-10 1984 J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0). susa 232-236 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6795191-2 1981 In view of the asymmetry in the disulfide bonding between SC and the IgA subunits, an arrangement which follows disulfide interchange, several models for the disulfide linkage of J chain and the bonds between IgA subunits were envisaged and investigated. Disulfides 32-41 joining chain of multimeric IgA and IgM Homo sapiens 179-186 6795191-8 1981 The available data thus favor a model in which J chain is disulfide-bonded to both IgA monomer subunits in sIgA. Disulfides 58-67 joining chain of multimeric IgA and IgM Homo sapiens 47-54 6417474-1 1983 J-chain staining of IgA- and IgM-producing immunocytes was significantly enhanced when tissue sections were pretreated with acid urea, apparently because molecular unfolding exposed concealed J-chains. acid urea 124-133 joining chain of multimeric IgA and IgM Homo sapiens 0-7 6417475-5 1983 In both PWM-stimulated (for 2 days) and unstimulated PBL, equal proportions of free and disulfide-linked J-chain were found. Disulfides 88-97 joining chain of multimeric IgA and IgM Homo sapiens 105-112 6417475-7 1983 In tissue culture fluids, J-chain was not secreted in a free form but was always disulfide-linked to polymeric Igs. Disulfides 81-90 joining chain of multimeric IgA and IgM Homo sapiens 26-33 6417475-8 1983 In lymphoblastoid cell lines, J-chain was present in a disulfide-linked form in IgM and IGA producers, but in IgG cells and in an IgM cell line (DAUDI) that did not secrete IgM but expressed it on the cell membrane, intracellular J-chain was present in free form. Disulfides 55-64 joining chain of multimeric IgA and IgM Homo sapiens 30-37 6417475-10 1983 Further studies revealed that the ability to produce polymers was not equally distributed among all cells and might vary according to their content of J-chain and stage of maturation. Polymers 53-61 joining chain of multimeric IgA and IgM Homo sapiens 151-158 6417475-12 1983 In lysates of IgG and J-chain producing cells grown in the presence of 3H-labeled amino acids, intracellular J-chain was not disulfide-linked to IgG. Tritium 71-73 joining chain of multimeric IgA and IgM Homo sapiens 22-29 6417475-12 1983 In lysates of IgG and J-chain producing cells grown in the presence of 3H-labeled amino acids, intracellular J-chain was not disulfide-linked to IgG. Tritium 71-73 joining chain of multimeric IgA and IgM Homo sapiens 109-116 6403880-3 1983 After acid-urea treatment of these tissue sections, J chain, a subunit of polymeric immunoglobulins, was identified in a distribution similar to that of IgA. acid-urea 6-15 joining chain of multimeric IgA and IgM Homo sapiens 52-59 6403880-5 1983 We conclude that the IgA deposits in at least some patients with Berger"s disease consist of IgA polymers linked by J chain. Polymers 97-105 joining chain of multimeric IgA and IgM Homo sapiens 116-123 6795624-4 1981 However, comparison of 5-methylcytosine contents showed that J chain gene expression correlates with a loss of methyl groups. 5-Methylcytosine 23-39 joining chain of multimeric IgA and IgM Homo sapiens 61-68 6795624-8 1981 The primary encounter of a B cell with antigen must therefore trigger events that effect J chain gene transcription through a mechanism involving loss of methyl groups from cytosine. Cytosine 173-181 joining chain of multimeric IgA and IgM Homo sapiens 89-96 6265589-3 1981 The primary translation products of J chain from all of these cell lines were found to be indistinguishable from one another by serologic criteria, by relative mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, by charge as judged by alkaline-urea gel electrophoresis, and by peptide mapping. Sodium Dodecyl Sulfate 172-194 joining chain of multimeric IgA and IgM Homo sapiens 36-43 6265589-3 1981 The primary translation products of J chain from all of these cell lines were found to be indistinguishable from one another by serologic criteria, by relative mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, by charge as judged by alkaline-urea gel electrophoresis, and by peptide mapping. polyacrylamide 195-209 joining chain of multimeric IgA and IgM Homo sapiens 36-43 6265589-3 1981 The primary translation products of J chain from all of these cell lines were found to be indistinguishable from one another by serologic criteria, by relative mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, by charge as judged by alkaline-urea gel electrophoresis, and by peptide mapping. Urea 263-267 joining chain of multimeric IgA and IgM Homo sapiens 36-43 16592469-6 1977 There is approximately a 20- to 40-ppm shielding of the (13)C chemical shifts of five- and six-coordinated carbons, compared with those of four valent carbons, with a simultaneous general increase of J(C-H) coupling constants. Carbon 107-114 joining chain of multimeric IgA and IgM Homo sapiens 200-205 6777426-2 1980 It was found that L&H type Sternberg-Reed cells of the nodular lymphocyte predominance type contained IgG, J chain, and one type of light chain per individual cell. l& 18-23 joining chain of multimeric IgA and IgM Homo sapiens 111-118 108268-0 1979 Structure of the oligosaccharide of human J chain. Oligosaccharides 17-32 joining chain of multimeric IgA and IgM Homo sapiens 42-49 108268-1 1979 The complete structure of the oligosaccharide moiety of J chain isolated from a Waldenstroms macroglobulin Wa has been established. Oligosaccharides 30-45 joining chain of multimeric IgA and IgM Homo sapiens 56-63 108268-3 1979 The structure and proportion of each of these is: formula : (see text) : Removal of the oligosaccharide moiety with glycosidases results in an increased mobility of J chain in sodium dodecyl sulfate polyacrylamide gel electrophoresis corresponding to a shift in apparent molecular weight from 23,500 to 19,500. Oligosaccharides 88-103 joining chain of multimeric IgA and IgM Homo sapiens 165-172 108268-3 1979 The structure and proportion of each of these is: formula : (see text) : Removal of the oligosaccharide moiety with glycosidases results in an increased mobility of J chain in sodium dodecyl sulfate polyacrylamide gel electrophoresis corresponding to a shift in apparent molecular weight from 23,500 to 19,500. Sodium Dodecyl Sulfate 176-198 joining chain of multimeric IgA and IgM Homo sapiens 165-172 108268-3 1979 The structure and proportion of each of these is: formula : (see text) : Removal of the oligosaccharide moiety with glycosidases results in an increased mobility of J chain in sodium dodecyl sulfate polyacrylamide gel electrophoresis corresponding to a shift in apparent molecular weight from 23,500 to 19,500. polyacrylamide 199-213 joining chain of multimeric IgA and IgM Homo sapiens 165-172 825142-0 1976 Esterification of J chain and its effect on electrophoretic mobility in sodium dodecyl sulfate polyacrylamide gels. Sodium Dodecyl Sulfate 72-94 joining chain of multimeric IgA and IgM Homo sapiens 18-25 407929-0 1977 Primary structure of human J chain: isolation and characterization of tryptic and chymotryptic peptides of human J chain. Peptides 95-103 joining chain of multimeric IgA and IgM Homo sapiens 27-34 407929-0 1977 Primary structure of human J chain: isolation and characterization of tryptic and chymotryptic peptides of human J chain. Peptides 95-103 joining chain of multimeric IgA and IgM Homo sapiens 113-120 825142-0 1976 Esterification of J chain and its effect on electrophoretic mobility in sodium dodecyl sulfate polyacrylamide gels. polyacrylamide 95-109 joining chain of multimeric IgA and IgM Homo sapiens 18-25 825142-1 1976 Sodium dodecyl sulfate polyacrylamide gel electrophoresis yields mobilities indicative of molecular weights of approximately 27 000 for human J chain and approximately 14 000 for nurse shark J chain, in contrast to values of approximately 15 500 and approximately 12 200, respectively, obtained by other methods. Sodium Dodecyl Sulfate 0-22 joining chain of multimeric IgA and IgM Homo sapiens 142-174 825142-1 1976 Sodium dodecyl sulfate polyacrylamide gel electrophoresis yields mobilities indicative of molecular weights of approximately 27 000 for human J chain and approximately 14 000 for nurse shark J chain, in contrast to values of approximately 15 500 and approximately 12 200, respectively, obtained by other methods. Sodium Dodecyl Sulfate 0-22 joining chain of multimeric IgA and IgM Homo sapiens 142-149 825142-1 1976 Sodium dodecyl sulfate polyacrylamide gel electrophoresis yields mobilities indicative of molecular weights of approximately 27 000 for human J chain and approximately 14 000 for nurse shark J chain, in contrast to values of approximately 15 500 and approximately 12 200, respectively, obtained by other methods. polyacrylamide 23-37 joining chain of multimeric IgA and IgM Homo sapiens 142-174 825142-1 1976 Sodium dodecyl sulfate polyacrylamide gel electrophoresis yields mobilities indicative of molecular weights of approximately 27 000 for human J chain and approximately 14 000 for nurse shark J chain, in contrast to values of approximately 15 500 and approximately 12 200, respectively, obtained by other methods. polyacrylamide 23-37 joining chain of multimeric IgA and IgM Homo sapiens 142-149 825142-2 1976 The relatively high content of acidic amino acids of human J chain as compared to nurse shark J chain suggested that the greater error in the sodium dodecyl sulfate determined molecular weight for human J chain may be due to a charge anomaly. Sodium Dodecyl Sulfate 142-164 joining chain of multimeric IgA and IgM Homo sapiens 59-66 825142-2 1976 The relatively high content of acidic amino acids of human J chain as compared to nurse shark J chain suggested that the greater error in the sodium dodecyl sulfate determined molecular weight for human J chain may be due to a charge anomaly. Sodium Dodecyl Sulfate 142-164 joining chain of multimeric IgA and IgM Homo sapiens 94-101 825142-2 1976 The relatively high content of acidic amino acids of human J chain as compared to nurse shark J chain suggested that the greater error in the sodium dodecyl sulfate determined molecular weight for human J chain may be due to a charge anomaly. Sodium Dodecyl Sulfate 142-164 joining chain of multimeric IgA and IgM Homo sapiens 94-101 825142-3 1976 The overall net negative charge on human J chain was decreased by forming methyl esters of the carboxyl groups, resulting in a sodium dodecyl sulfate determined molecular weight of approximately 17 700. Esters 81-87 joining chain of multimeric IgA and IgM Homo sapiens 41-48 825142-3 1976 The overall net negative charge on human J chain was decreased by forming methyl esters of the carboxyl groups, resulting in a sodium dodecyl sulfate determined molecular weight of approximately 17 700. Sodium Dodecyl Sulfate 127-149 joining chain of multimeric IgA and IgM Homo sapiens 41-48 1126937-8 1975 These results suggest that J chain is disulfide-bonded to only two of the subunits of polymeric IgA and that the remaining subunits in the higher polymers are disulfide-bonded one to the other. Disulfides 38-47 joining chain of multimeric IgA and IgM Homo sapiens 27-34 57921-4 1976 A polypeptide, homologous to human J chain, was isolated by chromatography on DEAE-cellulose from the reduced and alkylated X. laevis hexameric macroglobulin. DEAE-Cellulose 78-92 joining chain of multimeric IgA and IgM Homo sapiens 35-42 821140-4 1976 The SC-binding capacity of these polymers, expressed as percentage of the amount added (2.5 mu g SC/100 mug Ig), was 6%-12% compared with 69%-82% for IgA and IgM polymers that contained more than 4.0 mg of J chain per 100 mg. Polymers 33-41 joining chain of multimeric IgA and IgM Homo sapiens 206-213 821140-6 1976 Bound J chain therefore seems to be a structural prerequisite for a specific noncovalent complexing of Ig polymers with SC. Polymers 106-114 joining chain of multimeric IgA and IgM Homo sapiens 6-13 811140-4 1975 Polyacrylamide gel electrohoresis of the fractions eluted revealed the presence of light chain, alpha-chain secretory component, and J-chain. polyacrylamide 0-14 joining chain of multimeric IgA and IgM Homo sapiens 133-140 809510-1 1975 After the cleavage of disulfide bonds of macroglobulin isolated from channel catfish (Ictalurus punctatus), an electrophoretically fast-moving polypeptide, which resembled human J chain, was released. Disulfides 22-31 joining chain of multimeric IgA and IgM Homo sapiens 178-185 809510-2 1975 On a Sephadex G-200 column equilibrated in 5 M guanidine, the elution position of the J chain overlapped with the descending part of the L chain peak. sephadex 5-13 joining chain of multimeric IgA and IgM Homo sapiens 86-93 809510-2 1975 On a Sephadex G-200 column equilibrated in 5 M guanidine, the elution position of the J chain overlapped with the descending part of the L chain peak. Guanidine 47-56 joining chain of multimeric IgA and IgM Homo sapiens 86-93 809510-5 1975 A comparison of catfish and human J chain amino acid analyses showed the former to have a higher content of serine, glycine, and phenylalanine and a lower content of aspartic acid, isoleucine, and arginine. Serine 108-114 joining chain of multimeric IgA and IgM Homo sapiens 34-41 809510-5 1975 A comparison of catfish and human J chain amino acid analyses showed the former to have a higher content of serine, glycine, and phenylalanine and a lower content of aspartic acid, isoleucine, and arginine. Phenylalanine 129-142 joining chain of multimeric IgA and IgM Homo sapiens 34-41 1126937-3 1975 Only the dimer, with a sedimentation coefficient of 10.2 S, released J chain upon reduction with dithiothreitol. Dithiothreitol 97-111 joining chain of multimeric IgA and IgM Homo sapiens 69-76 4218099-0 1974 The amino acid sequence of the C- terminal cyanogen bromide peptide of human J chain. Cyanogen Bromide 43-59 joining chain of multimeric IgA and IgM Homo sapiens 77-84 814614-2 1975 The SC-binding site was completely blocked by J-chain antibody in those Ig polymers where the bound J chains were accessible to the antibody. Polymers 75-83 joining chain of multimeric IgA and IgM Homo sapiens 46-53 4202845-2 1973 Under these conditions, which selectively cleave intersubunit disulfides, J chain was released. Disulfides 62-72 joining chain of multimeric IgA and IgM Homo sapiens 74-81 4131279-1 1974 A fragment containing J chain was released from human polymeric myeloma IgA protein by cyanogen bromide cleavage. Cyanogen Bromide 87-103 joining chain of multimeric IgA and IgM Homo sapiens 22-29 4202845-5 1973 J chain was found in the 18.0S, noncovalently linked immunoglobulin M from which it was released only after more complete reduction with 10 mM dithiothreitol. Dithiothreitol 143-157 joining chain of multimeric IgA and IgM Homo sapiens 0-7 4131279-5 1974 The data indicate that J chain is attached to alpha chain(s) through the penultimate cysteine residue of the C-terminal octapeptide. Cysteine 85-93 joining chain of multimeric IgA and IgM Homo sapiens 23-30 4206912-0 1974 The molecular weight of J chains derived from human immunoglobulin M. J chain was isolated from sulphonated human immunoglobulin M molecules by electrophoresis on polyacrylamide gels. polyacrylamide 163-177 joining chain of multimeric IgA and IgM Homo sapiens 24-31 4206912-8 1974 These data suggest that J chain derived from the paraprotein exists in borate-saline solution as dimers held by strong non-covalent forces. Borates 71-77 joining chain of multimeric IgA and IgM Homo sapiens 24-31 4206912-8 1974 These data suggest that J chain derived from the paraprotein exists in borate-saline solution as dimers held by strong non-covalent forces. Sodium Chloride 78-84 joining chain of multimeric IgA and IgM Homo sapiens 24-31 4631861-0 1973 Structure of immunoglobulin A. Amino acid sequence of cysteine-containing peptides from the J chain. Cysteine 54-62 joining chain of multimeric IgA and IgM Homo sapiens 92-99 4199987-1 1973 Relationships between polymers and "J" chain. Polymers 22-30 joining chain of multimeric IgA and IgM Homo sapiens 36-44 4131279-5 1974 The data indicate that J chain is attached to alpha chain(s) through the penultimate cysteine residue of the C-terminal octapeptide. octapeptide 120-131 joining chain of multimeric IgA and IgM Homo sapiens 23-30