PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2684965-2	1989	Twelve monoclonal antibodies produced against the adult human intestinal enzyme were shown to recognize specifically SI by immunoprecipitation of 14C-labeled membrane proteins, analysis of enzyme activities in the immunoprecipitates, and immunoblotting.	Carbon-14	146-149	sucrase-isomaltase	Homo sapiens	117-119
2592430-0	1989	Reversible forskolin-induced impairment of sucrase-isomaltase mRNA levels, biosynthesis, and transport to the brush border membrane in Caco-2 cells.	Colforsin	11-20	sucrase-isomaltase	Homo sapiens	43-61
2592430-2	1989	Three effects are observed in Caco-2 cells treated with forskolin: 1) a marked decrease in the level of sucrase-isomaltase mRNA, 2) a marked decrease in the biosynthesis of the enzyme without any alteration of its stability, and 3) an almost total inhibition of its transport to the brush border membrane.	Colforsin	56-65	sucrase-isomaltase	Homo sapiens	104-122
2665651-6	1989	Since the glucose was released by alpha-glucosidase, the product must be glucosyl-alpha-glycerol.	Glucose	10-17	sucrase-isomaltase	Homo sapiens	34-51
2673693-1	1989	Miglitol (BAYm 1099), an alpha-glucosidase inhibitor, reduces the postprandial increase of blood glucose and serum insulin levels in type II (non-insulin-dependent) diabetes mellitus, as shown in short-term studies.	miglitol	10-19	sucrase-isomaltase	Homo sapiens	25-42
2665651-6	1989	Since the glucose was released by alpha-glucosidase, the product must be glucosyl-alpha-glycerol.	glucosyl-alpha-glycerol	73-96	sucrase-isomaltase	Homo sapiens	34-51
2656707-3	1989	As soon as 6 days after the addition of suramin (100 micrograms/ml) in the culture medium, the cells form a polarized monolayer of regular columnar cells with occluding junctions delimiting two distinct membrane domains (apical and basolateral) and an apical brush-border expressing alkaline phosphatase and sucrase-isomaltase.	Suramin	40-47	sucrase-isomaltase	Homo sapiens	308-326
2678346-1	1989	Acarbose, a potent alpha-glucosidase inhibitor, represents a new concept for the treatment of metabolic disorders, and particularly diabetes mellitus.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	19-36
2678346-2	1989	It slows the absorption kinetics of dietary carbohydrates by reversible competitive inhibition of alpha-glucosidase activity, and so reduces the post-prandial blood glucose increment and insulin response.	Carbohydrates	44-57	sucrase-isomaltase	Homo sapiens	98-115
2753897-6	1989	The N-acetylglucosaminides were inert toward alpha- and beta-glucosidase but were cleaved completely with N-acetylglucosaminidase.	n-acetylglucosaminides	4-26	sucrase-isomaltase	Homo sapiens	45-72
2546700-2	1989	BAY m 1099 inhibits neutral and acid alpha-glucosidase activities of both cell types in a dosage-dependent and reversible manner.	miglitol	0-10	sucrase-isomaltase	Homo sapiens	37-54
2655436-0	1989	Enteroglucagon release in disaccharide malabsorption induced by intestinal alpha-glucosidase inhibition.	Disaccharides	26-38	sucrase-isomaltase	Homo sapiens	75-92
2546700-4	1989	Competitive inhibition of mature acid alpha-glucosidase leads to lysosomal accumulation of glycogen as in glycogenosis type II.	Glycogen	91-99	sucrase-isomaltase	Homo sapiens	38-55
3071437-5	1988	The acid to neural alpha-glucosidase ratio only distinguished CF homozygotes from normal individuals when cells were extracted in Triton X-100.	Octoxynol	130-142	sucrase-isomaltase	Homo sapiens	19-36
2662474-2	1989	Acid and neutral alpha-glucosidase activities toward 4-methylumbelliferyl glucopyranoside as substrate were studied in total leucocytes, and separately in lymphocytes and granulocytes.	4-methylumbelliferyl glucopyranoside	53-89	sucrase-isomaltase	Homo sapiens	17-34
2687007-0	1989	Reduction of postprandial blood glucose by the alpha-glucosidase inhibitor Miglitol (BAY m 1099) in type II diabetes.	Blood Glucose	26-39	sucrase-isomaltase	Homo sapiens	47-64
2687007-0	1989	Reduction of postprandial blood glucose by the alpha-glucosidase inhibitor Miglitol (BAY m 1099) in type II diabetes.	miglitol	75-83	sucrase-isomaltase	Homo sapiens	47-64
2687007-0	1989	Reduction of postprandial blood glucose by the alpha-glucosidase inhibitor Miglitol (BAY m 1099) in type II diabetes.	miglitol	85-95	sucrase-isomaltase	Homo sapiens	47-64
2687007-1	1989	The dose-dependency of the effects of the alpha-glucosidase inhibitor Miglitol (Bay m 1099) was investigated in 8 Type II diabetic patients.	miglitol	70-78	sucrase-isomaltase	Homo sapiens	42-59
2687007-1	1989	The dose-dependency of the effects of the alpha-glucosidase inhibitor Miglitol (Bay m 1099) was investigated in 8 Type II diabetic patients.	miglitol	80-90	sucrase-isomaltase	Homo sapiens	42-59
2663321-0	1989	Effect of alpha-glucosidase inhibition on glucose profiles in insulin dependent diabetes.	Glucose	42-49	sucrase-isomaltase	Homo sapiens	10-27
3057329-2	1988	We have studied an orally active alpha-glucosidase inhibitor, Bay 1099, in normal volunteers to determine whether these inhibitors can decrease postprandial rises in serum glucose without causing gastrointestinal symptoms or significant fecal caloric wastage.	MIGLITOL	62-70	sucrase-isomaltase	Homo sapiens	33-50
2460027-6	1988	Both alpha-glucosidase and amylase were produced at 20- to 40-fold-higher levels when B. vulgatus was grown on maltose, amylose, or amylopectin than when B. vulgatus was grown on glucose or other monosaccharides.	Maltose	111-118	sucrase-isomaltase	Homo sapiens	5-22
3054280-4	1988	Thirteen type-2 diabetics on long-term treatment with the alpha-glucosidase inhibitor acarbose (3 x 100 mg per day) had test meals with and without acarbose 100 mg before and after the treatment period (mean 46 weeks), a test meal with acarbose after 20 weeks of continuous treatment and a final test meal without acarbose 6 weeks after cessation of treatment.	Acarbose	86-94	sucrase-isomaltase	Homo sapiens	58-75
2460027-6	1988	Both alpha-glucosidase and amylase were produced at 20- to 40-fold-higher levels when B. vulgatus was grown on maltose, amylose, or amylopectin than when B. vulgatus was grown on glucose or other monosaccharides.	Amylose	120-127	sucrase-isomaltase	Homo sapiens	5-22
2460027-6	1988	Both alpha-glucosidase and amylase were produced at 20- to 40-fold-higher levels when B. vulgatus was grown on maltose, amylose, or amylopectin than when B. vulgatus was grown on glucose or other monosaccharides.	Glucose	179-186	sucrase-isomaltase	Homo sapiens	5-22
2460027-6	1988	Both alpha-glucosidase and amylase were produced at 20- to 40-fold-higher levels when B. vulgatus was grown on maltose, amylose, or amylopectin than when B. vulgatus was grown on glucose or other monosaccharides.	Monosaccharides	196-211	sucrase-isomaltase	Homo sapiens	5-22
2460027-8	1988	The pIs and molecular weights of the B. vulgatus amylase and alpha-glucosidase were the same as those of the fecal enzymes.	Monothiopyrophosphoric acid	4-7	sucrase-isomaltase	Homo sapiens	61-78
3403721-3	1988	At least three phenotypes were revealed: one in which sucrase-isomaltase protein accumulated intracellularly probably in the endoplasmic reticulum, as a membrane-associated high-mannose precursor, one in which the intracellular transport of the enzyme was apparently blocked in the Golgi apparatus, and one in which catalytically altered enzyme was transported to the cell surface.	Mannose	178-185	sucrase-isomaltase	Homo sapiens	54-72
3403721-5	1988	The results suggest that different, probably small, mutations in the sucrase-isomaltase gene lead to the synthesis of transport-incompetent or functionally altered enzyme which results in congenital sucrose intolerance.	Sucrose	199-206	sucrase-isomaltase	Homo sapiens	69-87
2970619-0	1988	Receptor-mediated uptake of acid alpha-glucosidase corrects lysosomal glycogen storage in cultured skeletal muscle.	Glycogen	70-78	sucrase-isomaltase	Homo sapiens	33-50
3286363-0	1988	Fate and effects of the alpha-glucosidase inhibitor acarbose in humans.	Acarbose	52-60	sucrase-isomaltase	Homo sapiens	24-41
3286363-2	1988	The alpha-glucosidase inhibitor acarbose has been successfully used in diabetic patients to decrease the postprandial rise in blood glucose.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
3286363-2	1988	The alpha-glucosidase inhibitor acarbose has been successfully used in diabetic patients to decrease the postprandial rise in blood glucose.	Blood Glucose	126-139	sucrase-isomaltase	Homo sapiens	4-21
2970619-5	1988	Efficient uptake of acid alpha-glucosidase was achieved by using the mannose-6-phosphate receptor on the cell surface as a target for an enzyme precursor with phosphorylated high-mannose types carbohydrate chains purified from human urine.	Mannose	69-76	sucrase-isomaltase	Homo sapiens	25-42
2970619-5	1988	Efficient uptake of acid alpha-glucosidase was achieved by using the mannose-6-phosphate receptor on the cell surface as a target for an enzyme precursor with phosphorylated high-mannose types carbohydrate chains purified from human urine.	Carbohydrates	193-205	sucrase-isomaltase	Homo sapiens	25-42
3286168-1	1988	Bay-m-1099, a new alpha-glucosidase inhibitor, was given along with insulin immediately before standard breakfasts, lunches and dinners to nine insulin-dependent diabetic patients to determine whether this combination therapy would produce postprandial glycemic control comparable to that achieved when insulin alone was administered 30 min prior to eating.	miglitol	0-10	sucrase-isomaltase	Homo sapiens	18-35
2964235-1	1988	Administration in vivo of the alpha-glucosidase inhibitors 1-deoxynojirimycin and its derivatives BAY m 1099 (miglitol) and BAY o 1248 resulted in a dose- and time-dependent decrease in the rate of hepatic glycogenolysis induced by glucagon.	1-Deoxynojirimycin	59-77	sucrase-isomaltase	Homo sapiens	30-47
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	Hydrogen	0-2	sucrase-isomaltase	Homo sapiens	147-164
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	Deuterium	25-26	sucrase-isomaltase	Homo sapiens	147-164
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	gluco-octenitol	27-42	sucrase-isomaltase	Homo sapiens	147-164
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	Deuterium Oxide	54-57	sucrase-isomaltase	Homo sapiens	147-164
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	[2-2h]-d-gluco-octulose	90-113	sucrase-isomaltase	Homo sapiens	147-164
3042310-0	1988	Effects of BAYm 1099, new alpha-glucosidase inhibitor, on acute metabolic responses and metabolic control in NIDDM over 1 mo.	miglitol	11-20	sucrase-isomaltase	Homo sapiens	26-43
2964235-1	1988	Administration in vivo of the alpha-glucosidase inhibitors 1-deoxynojirimycin and its derivatives BAY m 1099 (miglitol) and BAY o 1248 resulted in a dose- and time-dependent decrease in the rate of hepatic glycogenolysis induced by glucagon.	Glucagon	232-240	sucrase-isomaltase	Homo sapiens	30-47
3130257-0	1988	Effects of prolonged administration of two new alpha-glucosidase inhibitors on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus.	Blood Glucose	79-92	sucrase-isomaltase	Homo sapiens	47-64
3286212-12	1988	Thus, acarbose represents the first of a new class of oral antidiabetic drugs--the alpha-glucosidase inhibitors.	Acarbose	6-14	sucrase-isomaltase	Homo sapiens	83-100
3134147-2	1988	Glucoamylase and alpha-glucosidase cannot hydrolyze BG5P because of the modification of the OH group of the 6-position of the non-reducing-end glucose residue with the benzyl group.	4-nitrophenyl-O-(6-O-benzyl)-glucopyranosyl(1--4)-O-glucopyranosyl(1--4)-O-glucopyranosyl(1--4)-O-glucopyranosyl(1--4)-glucopyranoside	52-56	sucrase-isomaltase	Homo sapiens	17-34
3134147-2	1988	Glucoamylase and alpha-glucosidase cannot hydrolyze BG5P because of the modification of the OH group of the 6-position of the non-reducing-end glucose residue with the benzyl group.	Glucose	143-150	sucrase-isomaltase	Homo sapiens	17-34
3134147-3	1988	Taking advantage of these characteristics of the substrate, BG5P, we developed a method to assay the total alpha-amylase activity in human fluids using glucoamylase and alpha-glucosidase as the coupled enzymes.	4-nitrophenyl-O-(6-O-benzyl)-glucopyranosyl(1--4)-O-glucopyranosyl(1--4)-O-glucopyranosyl(1--4)-O-glucopyranosyl(1--4)-glucopyranoside	60-64	sucrase-isomaltase	Homo sapiens	169-186
3130257-1	1988	Alpha-glucosidase inhibitors delay carbohydrate absorption.	Carbohydrates	35-47	sucrase-isomaltase	Homo sapiens	0-17
3277827-1	1988	The delay in glucose absorption at the intestinal level obtained with the administration of alpha-glucosidase inhibitors may contribute to an improved metabolic control in diabetic patients.	Glucose	13-20	sucrase-isomaltase	Homo sapiens	92-109
3311550-0	1987	A new alpha-glucosidase inhibitor (Bay-m-1099) reduces insulin requirements with meals in insulin-dependent diabetes mellitus.	miglitol	35-45	sucrase-isomaltase	Homo sapiens	6-23
3311550-2	1987	To determine the effects of Bay-m-1099, a new alpha-glucosidase inhibitor, on insulin requirements and prandial glucose tolerance in patients with insulin-dependent diabetes mellitus (IDDM), plasma glucose, triglyceride, and free insulin concentrations were measured after ingestion of a standard breakfast, lunch, and dinner in nine patients with IDDM in a single-blind, randomized, crossover design.	miglitol	28-38	sucrase-isomaltase	Homo sapiens	46-63
2825427-5	1987	A specific inhibitor of the receptor, N-acetyl galactosamine, as well as high concentrations of native glycoproteins and neoglycoproteins containing terminal galactose inhibited the receptor binding of the 125I-galactosylated alpha-glucosidase.	Acetylgalactosamine	38-60	sucrase-isomaltase	Homo sapiens	226-243
3316059-1	1987	The present study aimed at investigating the metabolic effects and tolerance of two desoxynojirimycin derivatives with alpha-glucosidase inhibitory properties (BAY m 1099 and BAY o 1248).	desoxynojirimycin	84-101	sucrase-isomaltase	Homo sapiens	119-136
2825427-5	1987	A specific inhibitor of the receptor, N-acetyl galactosamine, as well as high concentrations of native glycoproteins and neoglycoproteins containing terminal galactose inhibited the receptor binding of the 125I-galactosylated alpha-glucosidase.	Galactose	158-167	sucrase-isomaltase	Homo sapiens	226-243
3326689-2	1987	alpha-Glucosidase inhibitors delay carbohydrate absorption and have been proposed as adjunctive therapy for diabetes mellitus.	Carbohydrates	35-47	sucrase-isomaltase	Homo sapiens	0-17
3499444-7	1987	The problem of interference by serum alpha-glucosidase was solved by specific inhibition with tris (hydroxymethyl) aminomethane and erythritol.	Tromethamine	94-127	sucrase-isomaltase	Homo sapiens	37-54
3499444-7	1987	The problem of interference by serum alpha-glucosidase was solved by specific inhibition with tris (hydroxymethyl) aminomethane and erythritol.	Erythritol	132-142	sucrase-isomaltase	Homo sapiens	37-54
3553848-0	1987	The effect of short-term alpha-glucosidase inhibition on carbohydrate and lipid metabolism in type II (noninsulin-dependent) diabetics.	Carbohydrates	57-69	sucrase-isomaltase	Homo sapiens	25-42
16347392-4	1987	alpha-Amylase, pullulanase, and alpha-glucosidase were active in a broad temperature range (40 to 85 degrees C) and displayed temperature optima for activity at 60 to 70 degrees C. During incubation with starch under aerobic conditions at 75 degrees C for 2 h, the activity of both enzymes decreased to only 90 or 80%.	Starch	204-210	sucrase-isomaltase	Homo sapiens	32-49
16347392-5	1987	The apparent K(m) values of alpha-amylase, pullulanase, and alpha-glucosidase for their corresponding substrates, starch, pullulan, and maltose were 0.35 mg/ml, 0.63 mg/ml, and 25 mM, respectively.	Starch	114-120	sucrase-isomaltase	Homo sapiens	60-77
16347392-5	1987	The apparent K(m) values of alpha-amylase, pullulanase, and alpha-glucosidase for their corresponding substrates, starch, pullulan, and maltose were 0.35 mg/ml, 0.63 mg/ml, and 25 mM, respectively.	Maltose	136-143	sucrase-isomaltase	Homo sapiens	60-77
2434217-5	1987	Sucrase-isomaltase immunoisolated from HT-29 Glc- and Caco-2 cells reacted with anti-A antibodies and Ulex europaeus agglutinin-I (UEA-I), respectively, at sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblot.	Sodium Dodecyl Sulfate	156-178	sucrase-isomaltase	Homo sapiens	0-18
2434217-5	1987	Sucrase-isomaltase immunoisolated from HT-29 Glc- and Caco-2 cells reacted with anti-A antibodies and Ulex europaeus agglutinin-I (UEA-I), respectively, at sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblot.	polyacrylamide	179-193	sucrase-isomaltase	Homo sapiens	0-18
3108530-5	1987	Oligosaccharides excreted in urine are hydrolyzed enymatically to glucose using alpha-glucosidase and alpha-amylase, and the glucose released is measured by a test tape method.	Oligosaccharides	0-16	sucrase-isomaltase	Homo sapiens	80-97
3108530-5	1987	Oligosaccharides excreted in urine are hydrolyzed enymatically to glucose using alpha-glucosidase and alpha-amylase, and the glucose released is measured by a test tape method.	Glucose	66-73	sucrase-isomaltase	Homo sapiens	80-97
3807985-2	1987	The intestinal brush-border enzyme sucrase-isomaltase splits sucrose into its component monosaccharides, glucose and fructose.	Sucrose	61-68	sucrase-isomaltase	Homo sapiens	35-53
3807985-2	1987	The intestinal brush-border enzyme sucrase-isomaltase splits sucrose into its component monosaccharides, glucose and fructose.	Monosaccharides	88-103	sucrase-isomaltase	Homo sapiens	35-53
3807985-2	1987	The intestinal brush-border enzyme sucrase-isomaltase splits sucrose into its component monosaccharides, glucose and fructose.	Glucose	105-112	sucrase-isomaltase	Homo sapiens	35-53
3807985-2	1987	The intestinal brush-border enzyme sucrase-isomaltase splits sucrose into its component monosaccharides, glucose and fructose.	Fructose	117-125	sucrase-isomaltase	Homo sapiens	35-53
3302116-0	1987	Breakdown of lysosomal glycogen in cultured fibroblasts from glycogenosis type II patients after uptake of acid alpha-glucosidase.	Glycogen	23-31	sucrase-isomaltase	Homo sapiens	112-129
3302116-4	1987	The strict correlation between residual acid alpha-glucosidase activity and lysosomal glycogen accumulation was further illustrated in two adult Pompe patients with an unusually low enzyme activity.	Glycogen	86-94	sucrase-isomaltase	Homo sapiens	45-62
3298291-7	1987	The detected alpha-glucosidase activity was strongly inhibited by free mannosamine.	mannosamine	71-82	sucrase-isomaltase	Homo sapiens	13-30
3103953-1	1987	A new chromogenic substrate that is blocked at the nonreducing end, 4,6-benzylidene-alpha-D-4-nitrophenylmaltoheptaoside, is used to determine alpha-amylase (EC 3.2.1.1) activity in serum in a coupled assay with alpha-glucosidase (EC 3.2.1.20) and glucoamylase (EC 3.2.1.3) as auxiliary enzymes.	4-nitrophenyl maltoheptaoside	92-120	sucrase-isomaltase	Homo sapiens	212-229
3818665-2	1987	By removing a glucosylmannose disaccharide and yielding only one Man8GlcNAc isomer, this endo-alpha-D-mannosidase provides a processing route alternative to the sequential actions of alpha-glucosidase II and alpha-mannosidase I.	glucosylmannose disaccharide	14-42	sucrase-isomaltase	Homo sapiens	183-200
3818665-6	1987	The existence of an endo-alpha-D-mannosidase pathway for glucose removal could provide an explanation for the incomplete block in oligosaccharide processing which is observed in cells with inhibited or deficient alpha-glucosidase.	Oligosaccharides	130-145	sucrase-isomaltase	Homo sapiens	212-229
3553848-1	1987	With use of the alpha-glucosidase inhibitor bay g 5421 (acarbose), it is possible to improve glycemic profiles in diabetics without a concomitant increase in insulin levels or weight reduction.	Acarbose	44-54	sucrase-isomaltase	Homo sapiens	16-33
3553848-1	1987	With use of the alpha-glucosidase inhibitor bay g 5421 (acarbose), it is possible to improve glycemic profiles in diabetics without a concomitant increase in insulin levels or weight reduction.	Acarbose	56-64	sucrase-isomaltase	Homo sapiens	16-33
3553848-6	1987	In conclusion, inhibition of carbohydrate digestion with alpha-glucosidase inhibitors ameliorates many of the metabolic abnormalities in type II (noninsulin-dependent diabetics), suggesting that agents of this type can be of therapeutic value.	Carbohydrates	29-41	sucrase-isomaltase	Homo sapiens	57-74
3549325-1	1987	Miglitol is an alpha-glucosidase inhibitor which lowers blood glucose and insulin concentrations in healthy volunteers after a starch meal.	miglitol	0-8	sucrase-isomaltase	Homo sapiens	15-32
3549325-1	1987	Miglitol is an alpha-glucosidase inhibitor which lowers blood glucose and insulin concentrations in healthy volunteers after a starch meal.	Glucose	62-69	sucrase-isomaltase	Homo sapiens	15-32
2876919-1	1986	The biosynthesis and post-translational processing of sucrase-isomaltase and dipeptidylpeptidase IV were studied by L-[35S]methionine labeling, immunoisolation with monoclonal antibodies and SDS-PAGE in post-confluent Caco-2 cells treated with monensin (10 microM, 48 h).	L-Methionine-35S	116-133	sucrase-isomaltase	Homo sapiens	54-72
3106710-1	1987	We measured the activities of two major forms of alpha-glucosidase in lymphocytes and cultured fibroblasts from normal healthy controls and patients with Pompe"s disease by using 4-methylumbelliferyl-alpha-D-glucoside as substrate.	4-methylumbelliferyl-alpha-d-glucoside	179-217	sucrase-isomaltase	Homo sapiens	49-66
3540946-1	1986	Lysosomal acid alpha-glucosidase (EC 3.2.1.3) hydrolyzes 1,4-linked alpha-D-glucose polymers present in glycogen.	1,4-linked alpha-d-glucose polymers	57-92	sucrase-isomaltase	Homo sapiens	15-32
3540946-1	1986	Lysosomal acid alpha-glucosidase (EC 3.2.1.3) hydrolyzes 1,4-linked alpha-D-glucose polymers present in glycogen.	Glycogen	104-112	sucrase-isomaltase	Homo sapiens	15-32
2876919-1	1986	The biosynthesis and post-translational processing of sucrase-isomaltase and dipeptidylpeptidase IV were studied by L-[35S]methionine labeling, immunoisolation with monoclonal antibodies and SDS-PAGE in post-confluent Caco-2 cells treated with monensin (10 microM, 48 h).	Sodium Dodecyl Sulfate	191-194	sucrase-isomaltase	Homo sapiens	54-72
3530858-1	1986	Effect of the alpha-glucosidase inhibitor acarbose.	Acarbose	42-50	sucrase-isomaltase	Homo sapiens	14-31
2876919-1	1986	The biosynthesis and post-translational processing of sucrase-isomaltase and dipeptidylpeptidase IV were studied by L-[35S]methionine labeling, immunoisolation with monoclonal antibodies and SDS-PAGE in post-confluent Caco-2 cells treated with monensin (10 microM, 48 h).	Monensin	244-252	sucrase-isomaltase	Homo sapiens	54-72
3530858-3	1986	The effect of a 100-mg dose of the alpha-glucosidase inhibitor Acarbose ingested with the sucrose load was also investigated.	Acarbose	63-71	sucrase-isomaltase	Homo sapiens	35-52
3530858-3	1986	The effect of a 100-mg dose of the alpha-glucosidase inhibitor Acarbose ingested with the sucrose load was also investigated.	Sucrose	90-97	sucrase-isomaltase	Homo sapiens	35-52
3519244-0	1986	Effect of an alpha-glucosidase inhibitor (BAY m 1099) on post-prandial blood glucose and insulin in type II diabetics.	miglitol	42-52	sucrase-isomaltase	Homo sapiens	13-30
3527276-7	1986	It was shown that, as in the case of 125I-asialoorosomucoid, the binding of the 125I-galactosyl derivative of alpha-glucosidase occurred in the presence of Ca2+ and was inhibited by N-acetylgalactosamine.	Acetylgalactosamine	182-203	sucrase-isomaltase	Homo sapiens	110-127
3527276-8	1986	Glycoproteins containing galactose as a terminal residue inhibited the interaction of the receptor with 125I-galactolyzed alpha-glucosidase.	Galactose	25-34	sucrase-isomaltase	Homo sapiens	122-139
3519413-0	1986	Effects of prolonged (6 months) alpha-glucosidase inhibition on blood glucose control and insulin requirements in patients with insulin-dependent diabetes mellitus.	Blood Glucose	64-77	sucrase-isomaltase	Homo sapiens	32-49
3519413-1	1986	To examine prolonged alpha-glucosidase inhibition on blood glucose control, Acarbose, a potent alpha-glucosidase inhibitor, was administered for six months to insulin-dependent diabetic patients.	Acarbose	76-84	sucrase-isomaltase	Homo sapiens	21-38
3519413-1	1986	To examine prolonged alpha-glucosidase inhibition on blood glucose control, Acarbose, a potent alpha-glucosidase inhibitor, was administered for six months to insulin-dependent diabetic patients.	Acarbose	76-84	sucrase-isomaltase	Homo sapiens	95-112
3519413-4	1986	These results suggest that prolonged alpha-glucosidase inhibition improves glucose tolerance in patients with insulin-dependent diabetes mellitus.	Glucose	75-82	sucrase-isomaltase	Homo sapiens	37-54
3539737-0	1986	Smoothing effect of a new alpha-glucosidase inhibitor BAY m 1099 on blood glucose profiles of sulfonylurea-treated type II diabetic patients.	miglitol	54-64	sucrase-isomaltase	Homo sapiens	26-43
3539737-0	1986	Smoothing effect of a new alpha-glucosidase inhibitor BAY m 1099 on blood glucose profiles of sulfonylurea-treated type II diabetic patients.	Blood Glucose	68-81	sucrase-isomaltase	Homo sapiens	26-43
3539737-0	1986	Smoothing effect of a new alpha-glucosidase inhibitor BAY m 1099 on blood glucose profiles of sulfonylurea-treated type II diabetic patients.	Sulfonylurea Compounds	94-106	sucrase-isomaltase	Homo sapiens	26-43
3539737-1	1986	The alpha-glucosidase inhibitor BAY m 1099, a deoxynojirimycin derivative, was studied in sulfonylurea-treated type II diabetic patients using a placebo-controlled double-blind cross-over design.	miglitol	32-42	sucrase-isomaltase	Homo sapiens	4-21
3539737-6	1986	The alpha-glucosidase inhibitor BAY m 1099 might become a useful therapeutic tool in addition to sulfonylurea treatment in type II diabetes.	miglitol	32-42	sucrase-isomaltase	Homo sapiens	4-21
3095634-11	1986	The carbohydrates lactose and oligosaccharides as supplements to breast milk are hydrolysed by lactase, sucrase-isomaltase and maltase-glucoamylase.	Carbohydrates	4-17	sucrase-isomaltase	Homo sapiens	104-122
3095634-11	1986	The carbohydrates lactose and oligosaccharides as supplements to breast milk are hydrolysed by lactase, sucrase-isomaltase and maltase-glucoamylase.	Lactose	18-25	sucrase-isomaltase	Homo sapiens	104-122
3095634-11	1986	The carbohydrates lactose and oligosaccharides as supplements to breast milk are hydrolysed by lactase, sucrase-isomaltase and maltase-glucoamylase.	Oligosaccharides	30-46	sucrase-isomaltase	Homo sapiens	104-122
3525157-5	1986	Intracellular transport of endocytosed alpha-glucosidase was followed by incubating fibroblast homogenates with glycyl-L-phenylalanine-beta-naphthylamide (Gly-Phe-NH-Nap), which leads to specific lysis of lysosomes.	glycylphenylalanine 2-naphthylamide	112-153	sucrase-isomaltase	Homo sapiens	39-56
3525157-5	1986	Intracellular transport of endocytosed alpha-glucosidase was followed by incubating fibroblast homogenates with glycyl-L-phenylalanine-beta-naphthylamide (Gly-Phe-NH-Nap), which leads to specific lysis of lysosomes.	gly-phe-nh-nap	155-169	sucrase-isomaltase	Homo sapiens	39-56
3525157-7	1986	The first step in the processing of endocytosed alpha-glucosidase started in a Gly-Phe-NH-Nap-insensitive (prelysosomal) compartment, but further processing of the enzyme to lower-Mr forms was coupled to transport to the lysosomes.	gly-phe-nh-nap	79-93	sucrase-isomaltase	Homo sapiens	48-65
3520133-1	1986	BAYo1248 and BAYm1099 are two new alpha-glucosidase inhibitors.	emiglitate	0-8	sucrase-isomaltase	Homo sapiens	34-51
3520133-1	1986	BAYo1248 and BAYm1099 are two new alpha-glucosidase inhibitors.	miglitol	13-21	sucrase-isomaltase	Homo sapiens	34-51
3520133-3	1986	Postprandial breath H2 concentrations were mildly increased when these alpha-glucosidase inhibitors were given and no patient complained of any adverse effects (such as flatulence, abdominal pain or diarrhea).	Hydrogen	20-22	sucrase-isomaltase	Homo sapiens	71-88
3522516-6	1986	A positive correlation was observed between carnitine and alpha-glucosidase activity.	Carnitine	44-53	sucrase-isomaltase	Homo sapiens	58-75
2951158-1	1986	Seventeen non-insulin-dependent diabetics poorly controlled by diet and sulphonylurea drugs took part in a long-term (20-52 weeks) trial of the effect of an alpha-glucosidase inhibitor (acarbose 100 mg thrice daily) on postprandial glycaemic and gastro-entero-pancreatic hormone responses.	Acarbose	186-194	sucrase-isomaltase	Homo sapiens	157-174
3519244-1	1986	The effect of a new alpha-glucosidase inhibitor (BAY m 1099), a 1-deoxynojirimycin derivative, was studied in 10 black patients with Type II diabetes mellitus.	miglitol	49-59	sucrase-isomaltase	Homo sapiens	20-37
3519244-1	1986	The effect of a new alpha-glucosidase inhibitor (BAY m 1099), a 1-deoxynojirimycin derivative, was studied in 10 black patients with Type II diabetes mellitus.	1-DEOXYNOJIRIMYCIN	64-82	sucrase-isomaltase	Homo sapiens	20-37
3527720-0	1986	Effects of the alpha-glucosidase inhibitor 1 desoxynojirimycin (Bay m 1099) on postprandial blood glucose, serum insulin and C-peptide levels in type II diabetic patients.	miglitol	64-74	sucrase-isomaltase	Homo sapiens	15-32
3527720-1	1986	Bay m 1099 is a newly developed inhibitor of intestinal alpha-glucosidase.	miglitol	0-10	sucrase-isomaltase	Homo sapiens	56-73
2417186-1	1985	Incubation of zymosan particles with serum was shown to be accompanied by their partial breakdown into the oligosaccharides maltose, maltotriose, and maltotetraose, that were quantified under the form of glucose after degradation by alpha-glucosidase.	Zymosan	14-21	sucrase-isomaltase	Homo sapiens	233-250
2866240-2	1985	The high-mannose glycosylated form of sucrase-isomaltase was found to have a lower specific activity than the complex glycosylated form, whereas no difference was observed for the two other enzymes.	Mannose	9-16	sucrase-isomaltase	Homo sapiens	38-56
2866240-3	1985	The change in glycosylation from high-mannose to complex form thus seems to be of importance for the enzymatic activity of sucrase-isomaltase either by direct structural involvement or by a general stabilization effect on the protein conformation.	Mannose	38-45	sucrase-isomaltase	Homo sapiens	123-141
2417186-1	1985	Incubation of zymosan particles with serum was shown to be accompanied by their partial breakdown into the oligosaccharides maltose, maltotriose, and maltotetraose, that were quantified under the form of glucose after degradation by alpha-glucosidase.	maltotetraose	150-163	sucrase-isomaltase	Homo sapiens	233-250
3897250-5	1985	Pulse-chase studies with [35S]methionine and analysis by subunit-specific monoclonal antibodies revealed that sucrase-isomaltase was synthesized and persisted as a single-chain protein comprising both subunits.	Sulfur-35	26-29	sucrase-isomaltase	Homo sapiens	110-128
2932444-1	1985	The carbohydrate structures of acid phosphatase and alpha-glucosidase secreted into culture medium by Tetrahymena pyriformis strain W were studied.	Carbohydrates	4-16	sucrase-isomaltase	Homo sapiens	52-69
2932444-3	1985	The approximate amounts of total sugar chains liberated from 1 mol each of acid phosphatase and alpha-glucosidase were 6 and 4 mol, respectively.	Sugars	33-38	sucrase-isomaltase	Homo sapiens	96-113
3899200-6	1985	Sucrose density gradient fractions analyzed for their enzyme content in the absence or presence of sodium dodecyl sulfate (1% w/v), a selective inhibitor of acid alpha-glucosidase activity, allowed the demonstration of two enzyme forms at pH 6.8 in rete testis fluid sedimenting in the 7S and 4S regions of the gradient, while a unique 4S form was encountered in cauda epididymidis and in seminal plasma.	Sucrose	0-7	sucrase-isomaltase	Homo sapiens	162-179
3899200-6	1985	Sucrose density gradient fractions analyzed for their enzyme content in the absence or presence of sodium dodecyl sulfate (1% w/v), a selective inhibitor of acid alpha-glucosidase activity, allowed the demonstration of two enzyme forms at pH 6.8 in rete testis fluid sedimenting in the 7S and 4S regions of the gradient, while a unique 4S form was encountered in cauda epididymidis and in seminal plasma.	Sodium Dodecyl Sulfate	99-121	sucrase-isomaltase	Homo sapiens	162-179
3905406-5	1985	When a homogenate of fibroblasts was incubated for 20 min with 0.5 mM Gly-Phe-NH-Nap, a substrate for the lysosomal enzyme cathepsin C, the latency of the lysosomal enzymes alpha-glucosidase and beta-hexosaminidase decreased from 75% to 10% and their sedimentability from 75% to 20-30%.	gly-phe-nh-nap	70-84	sucrase-isomaltase	Homo sapiens	173-190
3905406-8	1985	When homogenates of labelled fibroblasts were incubated with Gly-Phe-NH-Nap prior to immunoprecipitation, 70-80% of all proteolytically processed forms of metabolically labelled alpha-glucosidase and cathepsin D was recovered in the supernatant.	gly-phe-nh-nap	61-75	sucrase-isomaltase	Homo sapiens	178-195
3905406-11	1985	Whereas newly synthesized cathepsin D was found in the lysosomes 1 h after synthesis, alpha-glucosidase was detected only after 2-4 h. When a pulse-chase experiment was carried out in the presence of 10 mM NH4Cl there was a complete inhibition of the transport of cathepsin D and a partial inhibition of that of alpha-glucosidase to the lysosomes.	Ammonium Chloride	206-211	sucrase-isomaltase	Homo sapiens	86-103
3905406-11	1985	Whereas newly synthesized cathepsin D was found in the lysosomes 1 h after synthesis, alpha-glucosidase was detected only after 2-4 h. When a pulse-chase experiment was carried out in the presence of 10 mM NH4Cl there was a complete inhibition of the transport of cathepsin D and a partial inhibition of that of alpha-glucosidase to the lysosomes.	Ammonium Chloride	206-211	sucrase-isomaltase	Homo sapiens	312-329
3897250-5	1985	Pulse-chase studies with [35S]methionine and analysis by subunit-specific monoclonal antibodies revealed that sucrase-isomaltase was synthesized and persisted as a single-chain protein comprising both subunits.	Methionine	30-40	sucrase-isomaltase	Homo sapiens	110-128
3925457-6	1985	This protein presumably is the high-mannose precursor of sucrase-isomaltase.	Mannose	36-43	sucrase-isomaltase	Homo sapiens	57-75
3877577-3	1985	Under the assay conditions, the absorption of 2-chloro-4-nitrophenol (CNP) generated by the secondary reaction of alpha-glucosidase and beta-glucosidase as auxiliary enzymes is about twice the absorption of 4-nitrophenol (PNP), which is the end product currently measured in some alpha-amylase assay methods.	2-chloro-4-nitrophenol	46-68	sucrase-isomaltase	Homo sapiens	114-131
3877577-3	1985	Under the assay conditions, the absorption of 2-chloro-4-nitrophenol (CNP) generated by the secondary reaction of alpha-glucosidase and beta-glucosidase as auxiliary enzymes is about twice the absorption of 4-nitrophenol (PNP), which is the end product currently measured in some alpha-amylase assay methods.	2-chloro-4-nitrophenol	70-73	sucrase-isomaltase	Homo sapiens	114-131
3877577-3	1985	Under the assay conditions, the absorption of 2-chloro-4-nitrophenol (CNP) generated by the secondary reaction of alpha-glucosidase and beta-glucosidase as auxiliary enzymes is about twice the absorption of 4-nitrophenol (PNP), which is the end product currently measured in some alpha-amylase assay methods.	4-nitrophenol	55-68	sucrase-isomaltase	Homo sapiens	114-131
3877577-3	1985	Under the assay conditions, the absorption of 2-chloro-4-nitrophenol (CNP) generated by the secondary reaction of alpha-glucosidase and beta-glucosidase as auxiliary enzymes is about twice the absorption of 4-nitrophenol (PNP), which is the end product currently measured in some alpha-amylase assay methods.	4-nitrophenol	222-225	sucrase-isomaltase	Homo sapiens	114-131
3888274-1	1985	The molecular basis for charge heterogeneity in human hepatic alpha-glucosidase (alpha-D-glucoside glucohydrolase, EC 3.2.1.20) was determined by analysis of the carbohydrate and polypeptide components of the enzyme.	Carbohydrates	162-174	sucrase-isomaltase	Homo sapiens	62-79
3893420-0	1985	Lysosomal glycogen storage induced by Acarbose, a 1,4-alpha-glucosidase inhibitor.	Acarbose	38-46	sucrase-isomaltase	Homo sapiens	54-71
3888274-3	1985	Four enzymatically active forms of alpha-glucosidase separated by chromatofocusing were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and were found to contain different polypeptides.	Sodium Dodecyl Sulfate	100-122	sucrase-isomaltase	Homo sapiens	35-52
3888274-3	1985	Four enzymatically active forms of alpha-glucosidase separated by chromatofocusing were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and were found to contain different polypeptides.	polyacrylamide	123-137	sucrase-isomaltase	Homo sapiens	35-52
3880764-4	1985	The differentiation of Glc- cells is reversible: the addition of glucose to postconfluent cultures of Glc- cells results in an inhibiting effect on the expression of sucrase-isomaltase; switching growing cultures of Glc- cells to the Glc+ medium for several passages results in a progressive reversion to the undifferentiated state, which is completed after seven passages.	Glucose	65-72	sucrase-isomaltase	Homo sapiens	166-184
2579146-6	1985	Enzymatic hydrolysis of beta-glucan and alpha-mannan with beta-glucosidase or beta-glucanase before their incubation with monocytes abrogated their inhibitory capacity, whereas hydrolysis with alpha-mannosidase or alpha-glucosidase did not.	beta-Glucans	24-35	sucrase-isomaltase	Homo sapiens	214-231
2579146-6	1985	Enzymatic hydrolysis of beta-glucan and alpha-mannan with beta-glucosidase or beta-glucanase before their incubation with monocytes abrogated their inhibitory capacity, whereas hydrolysis with alpha-mannosidase or alpha-glucosidase did not.	alpha-mannan	40-52	sucrase-isomaltase	Homo sapiens	214-231
2933261-1	1985	BAY m1099 (a 1-deoxynojirimycin derivative) is a glucose analogue which is an alpha-glucosidase inhibitor.	1-DEOXYNOJIRIMYCIN	13-31	sucrase-isomaltase	Homo sapiens	78-95
2933261-1	1985	BAY m1099 (a 1-deoxynojirimycin derivative) is a glucose analogue which is an alpha-glucosidase inhibitor.	Glucose	49-56	sucrase-isomaltase	Homo sapiens	78-95
3905582-0	1985	Detection of human acid alpha-glucosidase in fibroblasts using monoclonal antibodies in a biotin-avidin amplified ELISA.	Biotin	90-96	sucrase-isomaltase	Homo sapiens	24-41
6394601-1	1984	Mammalian muscle acid alpha-glucosidase was highly purified for the first time from rabbit muscle by fractionation with ammonium sulfate, and chromatographies on Sephadex G-100, CM-TOYOPEARL and TOYOPEARL HW-55.	Ammonium Sulfate	120-136	sucrase-isomaltase	Homo sapiens	22-39
6394601-5	1984	The alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans, such as soluble starch, beta-limit dextrin, amylopectin, shellfish glycogen, and amylose.	Maltose	70-77	sucrase-isomaltase	Homo sapiens	4-21
3891151-6	1985	Renal alpha-glucosidase has a higher affinity for maltose (Km, 0.8 mmol/l) than acid enzyme, however; for glycogen acid enzyme shows the highest affinity (20.7 g/l).	Maltose	50-57	sucrase-isomaltase	Homo sapiens	6-23
3891151-6	1985	Renal alpha-glucosidase has a higher affinity for maltose (Km, 0.8 mmol/l) than acid enzyme, however; for glycogen acid enzyme shows the highest affinity (20.7 g/l).	Glycogen	106-114	sucrase-isomaltase	Homo sapiens	6-23
2409582-4	1985	The addition of an alpha-glucosidase inhibitor (acarbose) to a sucrose- or maltose-rich semisynthetic diet did not cause significant alteration in pancreatic growth or enzyme composition or secretion.	Acarbose	48-56	sucrase-isomaltase	Homo sapiens	19-36
6394601-5	1984	The alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans, such as soluble starch, beta-limit dextrin, amylopectin, shellfish glycogen, and amylose.	alpha-glucans	94-107	sucrase-isomaltase	Homo sapiens	4-21
6394601-5	1984	The alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans, such as soluble starch, beta-limit dextrin, amylopectin, shellfish glycogen, and amylose.	Starch	125-131	sucrase-isomaltase	Homo sapiens	4-21
6394601-5	1984	The alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans, such as soluble starch, beta-limit dextrin, amylopectin, shellfish glycogen, and amylose.	beta-limit dextrin	133-151	sucrase-isomaltase	Homo sapiens	4-21
6394601-5	1984	The alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans, such as soluble starch, beta-limit dextrin, amylopectin, shellfish glycogen, and amylose.	Glycogen	176-184	sucrase-isomaltase	Homo sapiens	4-21
6394601-5	1984	The alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans, such as soluble starch, beta-limit dextrin, amylopectin, shellfish glycogen, and amylose.	Amylose	190-197	sucrase-isomaltase	Homo sapiens	4-21
6394601-11	1984	The purified enzyme was a typical acid alpha-glucosidase of mammalian origin, which hydrolyzed various substrates to produce alpha-glucose.	alpha-D-glucose	125-138	sucrase-isomaltase	Homo sapiens	39-56
6394601-17	1984	From these results, it was concluded that rabbit muscle acid alpha-glucosidase attacks maltose and glycogen by a single active site mechanism.	Maltose	87-94	sucrase-isomaltase	Homo sapiens	61-78
6394601-17	1984	From these results, it was concluded that rabbit muscle acid alpha-glucosidase attacks maltose and glycogen by a single active site mechanism.	Glycogen	99-107	sucrase-isomaltase	Homo sapiens	61-78
3880764-4	1985	The differentiation of Glc- cells is reversible: the addition of glucose to postconfluent cultures of Glc- cells results in an inhibiting effect on the expression of sucrase-isomaltase; switching growing cultures of Glc- cells to the Glc+ medium for several passages results in a progressive reversion to the undifferentiated state, which is completed after seven passages.	Glucose	23-26	sucrase-isomaltase	Homo sapiens	166-184
6355365-3	1983	In the first step of the assay of neutral alpha-glucosidase, glucose was liberated from maltose (citrate-phosphate buffer, pH 6.8, 20 mmol/l maltose, 25 mmol/l turanose).	Glucose	61-68	sucrase-isomaltase	Homo sapiens	42-59
6743024-1	1984	The alpha-glucosidase inhibitor bromoconduritol inhibits the formation of the N-linked, complex-type oligosaccharides of the glycoproteins from influenza viruses (fowl plague virus, influenza virus PR-8) and from sindbis virus.	6-bromoconduritol	32-47	sucrase-isomaltase	Homo sapiens	4-21
6743024-1	1984	The alpha-glucosidase inhibitor bromoconduritol inhibits the formation of the N-linked, complex-type oligosaccharides of the glycoproteins from influenza viruses (fowl plague virus, influenza virus PR-8) and from sindbis virus.	n-linked, complex-type oligosaccharides	78-117	sucrase-isomaltase	Homo sapiens	4-21
6743024-3	1984	Other alpha-glucosidase inhibitors (nojirimycin, deoxynojirimycin, acarbose) were not specific inhibitors of oligosaccharide processing under the conditions used in the present investigation.	nojirimycin	36-47	sucrase-isomaltase	Homo sapiens	6-23
6743024-3	1984	Other alpha-glucosidase inhibitors (nojirimycin, deoxynojirimycin, acarbose) were not specific inhibitors of oligosaccharide processing under the conditions used in the present investigation.	Acarbose	67-75	sucrase-isomaltase	Homo sapiens	6-23
6240271-5	1984	The specific activities of neutral alpha-glucosidase and beta-N-acetylhexosaminidase are scarcely influenced by butacaine alone.	butacaine	112-121	sucrase-isomaltase	Homo sapiens	35-52
6365214-0	1983	[Control of the urinary excretion of the enzyme alpha-glucosidase during the administration of fluoride tablets].	Fluorides	95-103	sucrase-isomaltase	Homo sapiens	48-65
6400709-2	1983	Fourteen insulin-dependent diabetic patients were treated for 6 wk with the alpha-glucosidase inhibitor, acarbose, in a double-blind crossover study to see whether the drug would delay absorption of the evening meal sufficiently to correct the mismatch and prevent nocturnal hypoglycemia.	Acarbose	105-113	sucrase-isomaltase	Homo sapiens	76-93
6235982-1	1984	Antisera were raised in rabbits against native and sodium dodecylsulfate denatured forms of human acid alpha-glucosidase and beta-hexosaminidases A and B. Anti-native enzyme antisera were able to precipitate all or nearly all enzyme activity from cell extracts, and to eliminate all stainable activity on electrophoresis.	Sodium Dodecyl Sulfate	51-72	sucrase-isomaltase	Homo sapiens	103-120
6426521-5	1984	p-Aminophenyl-beta-D-galactopyranoside residues incorporated in alpha-glucosidase and in other proteins were found to be antigenic determinants to which the pure antibodies were obtained.	4-aminophenyl-beta-galactoside	0-38	sucrase-isomaltase	Homo sapiens	64-81
6365553-2	1984	In the second step, affinity chromatography on Sephadex G-100, two fractions with acid alpha-glucosidase activity were obtained.	sephadex	47-61	sucrase-isomaltase	Homo sapiens	87-104
6365553-4	1984	alpha-Glucosidase in fraction I had an Mr similar to that of the precursor of alpha-glucosidase detected in the medium of fibroblasts after labelling with [14C]leucine.	Carbon-14	156-159	sucrase-isomaltase	Homo sapiens	0-17
6365553-4	1984	alpha-Glucosidase in fraction I had an Mr similar to that of the precursor of alpha-glucosidase detected in the medium of fibroblasts after labelling with [14C]leucine.	Carbon-14	156-159	sucrase-isomaltase	Homo sapiens	78-95
6365553-4	1984	alpha-Glucosidase in fraction I had an Mr similar to that of the precursor of alpha-glucosidase detected in the medium of fibroblasts after labelling with [14C]leucine.	Leucine	160-167	sucrase-isomaltase	Homo sapiens	0-17
6365553-4	1984	alpha-Glucosidase in fraction I had an Mr similar to that of the precursor of alpha-glucosidase detected in the medium of fibroblasts after labelling with [14C]leucine.	Leucine	160-167	sucrase-isomaltase	Homo sapiens	78-95
6365553-6	1984	alpha-Glucosidase in fraction I contained mannose 6-phosphate (3.5 mol/mol polypeptide).	mannose-6-phosphate	42-61	sucrase-isomaltase	Homo sapiens	0-17
6365553-10	1984	The pH optimum and Km values for p-nitrophenyl alpha-glucoside, maltose and glycogen of fractions I and II alpha-glucosidase were almost identical.	4-nitrophenyl alpha-glucoside	33-62	sucrase-isomaltase	Homo sapiens	107-124
6365553-10	1984	The pH optimum and Km values for p-nitrophenyl alpha-glucoside, maltose and glycogen of fractions I and II alpha-glucosidase were almost identical.	Glycogen	76-84	sucrase-isomaltase	Homo sapiens	107-124
6369775-4	1984	Neutral alpha-glucosidase from granulocytes exhibited more wide pH optimum as compared with the lymphocyte enzyme, at the same time, the granulocyte enzyme was stable at pH 4.0, 37 degrees, 15 min and was inhibited by turanose.	turanose	218-226	sucrase-isomaltase	Homo sapiens	8-25
6355365-8	1983	The effect of turanose and potassium ions on neutral and acid alpha-glucosidase from human urine was characterized.	turanose	14-22	sucrase-isomaltase	Homo sapiens	62-79
6355365-8	1983	The effect of turanose and potassium ions on neutral and acid alpha-glucosidase from human urine was characterized.	Potassium	27-36	sucrase-isomaltase	Homo sapiens	62-79
6355366-2	1983	Urinary excretion of neutral and acid alpha-glucosidase in reference subjects was found to be in the range 1.61 to 20.36 microkat/mol creatinine and 7.47 to 33.60 microkat/mol creatinine, respectively.	Creatinine	134-144	sucrase-isomaltase	Homo sapiens	38-55
6355366-2	1983	Urinary excretion of neutral and acid alpha-glucosidase in reference subjects was found to be in the range 1.61 to 20.36 microkat/mol creatinine and 7.47 to 33.60 microkat/mol creatinine, respectively.	Creatinine	176-186	sucrase-isomaltase	Homo sapiens	38-55
6355365-3	1983	In the first step of the assay of neutral alpha-glucosidase, glucose was liberated from maltose (citrate-phosphate buffer, pH 6.8, 20 mmol/l maltose, 25 mmol/l turanose).	Maltose	88-95	sucrase-isomaltase	Homo sapiens	42-59
6355365-3	1983	In the first step of the assay of neutral alpha-glucosidase, glucose was liberated from maltose (citrate-phosphate buffer, pH 6.8, 20 mmol/l maltose, 25 mmol/l turanose).	citrate phosphate	97-114	sucrase-isomaltase	Homo sapiens	42-59
6355365-4	1983	Under these incubation conditions, turanose inhibited the residual activity of acid alpha-glucosidase almost completely without influencing the activity of neutral alpha-glucosidase.	turanose	35-43	sucrase-isomaltase	Homo sapiens	84-101
6355365-5	1983	In the first step of the acid alpha-glucosidase assay, glucose was liberated from maltose (citrate-phosphate buffer, pH 3.8, 50 mmol/l maltose, 2 mol/l potassium chloride).	Glucose	55-62	sucrase-isomaltase	Homo sapiens	30-47
6355365-5	1983	In the first step of the acid alpha-glucosidase assay, glucose was liberated from maltose (citrate-phosphate buffer, pH 3.8, 50 mmol/l maltose, 2 mol/l potassium chloride).	Maltose	82-89	sucrase-isomaltase	Homo sapiens	30-47
6355365-6	1983	Under these incubation conditions, potassium ions stimulate the activity of acid alpha-glucosidase and simultaneously inhibit almost completely the residual activity of neutral alpha-glucosidase.	Potassium	35-44	sucrase-isomaltase	Homo sapiens	81-98
6355365-6	1983	Under these incubation conditions, potassium ions stimulate the activity of acid alpha-glucosidase and simultaneously inhibit almost completely the residual activity of neutral alpha-glucosidase.	Potassium	35-44	sucrase-isomaltase	Homo sapiens	177-194
6355365-7	1983	In the second step of the assay of neutral and acid alpha-glucosidase, the liberated glucose was measured by hexokinase/glucose-6-phosphate dehydrogenase.	Glucose	85-92	sucrase-isomaltase	Homo sapiens	52-69
6353754-4	1983	Both forms of neutral alpha-glucosidase I and 2 from human urine exhibited the maximal activity at pH 5.75 = 6.5, had a similar Km value (0.73 mM) with maltose as a substrate and did not differ in their properties from the corresponding forms of neutral alpha-glucosidase in a soluble fraction from human kidney.	Maltose	152-159	sucrase-isomaltase	Homo sapiens	22-39
6347194-0	1983	Disturbance of lysosomal glycogen metabolism by liposomal anti-alpha-glucosidase and some anti-inflammatory drugs.	Glycogen	25-33	sucrase-isomaltase	Homo sapiens	63-80
7048734-0	1982	[Effect of periodate oxidation on activity of acid alpha-glucosidase from human liver].	metaperiodate	11-20	sucrase-isomaltase	Homo sapiens	51-68
6761145-2	1982	When the labelling was carried out for 6-12 h in the presence of NH4Cl, the labelling of secreted alpha-glucosidase relative to that of secreted cathepsin D in fibroblasts from patients with the late-onset form of Pompe"s disease was less than 15% of that in fibroblasts from control persons.	Ammonium Chloride	65-70	sucrase-isomaltase	Homo sapiens	98-115
6751595-6	1982	Experiments involving dialysis of patient serum, addition of glucose to patient serum and mixing of control and diabetic patient sera all suggest that glucose exhibits only slight inhibition of serum neutral alpha-glucosidase activity.	Glucose	151-158	sucrase-isomaltase	Homo sapiens	208-225
7052147-0	1982	[Chemical attachment of p-aminophenylgalactoside to acid alpha-glucosidase from human liver].	p-aminophenylgalactoside	24-48	sucrase-isomaltase	Homo sapiens	57-74
7052147-1	1982	Chemical modification of the COOH-groups of acid alpha-glucosidase from human liver by 1-ethyl-3 (3"-dimethylaminopropyl) carbodiimide.	Carbonic Acid	29-33	sucrase-isomaltase	Homo sapiens	49-66
7052147-1	1982	Chemical modification of the COOH-groups of acid alpha-glucosidase from human liver by 1-ethyl-3 (3"-dimethylaminopropyl) carbodiimide.	Ethyldimethylaminopropyl Carbodiimide	87-134	sucrase-isomaltase	Homo sapiens	49-66
6411473-5	1983	Additional administration of an alpha-glucosidase inhibitor in four patients caused a significant increase in blood lactate despite unchanged blood glucose levels.	Glucose	148-155	sucrase-isomaltase	Homo sapiens	32-49
6357634-3	1983	The assembly of sucrase-isomaltase into phospholipid bilayers has been reported to result in a model membrane system which resembles the "native" brush border membrane as regards the mode of lipid-protein interaction.	Phospholipids	40-52	sucrase-isomaltase	Homo sapiens	16-34
7048734-1	1982	Treatment with sodium metaperiodate caused oxidation of carbohydrate residues in acid alpha-glucosidase (gamma-amylase).	metaperiodate	15-35	sucrase-isomaltase	Homo sapiens	86-103
7048734-1	1982	Treatment with sodium metaperiodate caused oxidation of carbohydrate residues in acid alpha-glucosidase (gamma-amylase).	Carbohydrates	56-68	sucrase-isomaltase	Homo sapiens	86-103
7048734-2	1982	Efficiency of the oxidation was monitored by a decrease in specific binding of alpha-glucosidase with concanavaline A-Sepharose.	concanavaline a	102-117	sucrase-isomaltase	Homo sapiens	79-96
7048734-2	1982	Efficiency of the oxidation was monitored by a decrease in specific binding of alpha-glucosidase with concanavaline A-Sepharose.	Sepharose	118-127	sucrase-isomaltase	Homo sapiens	79-96
6803351-1	1982	Inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose, sucrose and lactose was carried out with the alpha-glucosidase inhibitor, acarbose.	Disaccharides	86-99	sucrase-isomaltase	Homo sapiens	154-171
6176360-2	1982	Two p-nitrophenyl-alpha-maltaosides are used as substrates, which amylase cleaves to shorter-chain p-nitrophenyl maltaosides, the latter then yielding p-nitrophenol from the activity of alpha-glucosidase.	p-nitrophenyl-alpha-maltaosides	4-35	sucrase-isomaltase	Homo sapiens	186-203
6176360-2	1982	Two p-nitrophenyl-alpha-maltaosides are used as substrates, which amylase cleaves to shorter-chain p-nitrophenyl maltaosides, the latter then yielding p-nitrophenol from the activity of alpha-glucosidase.	p-nitrophenyl maltaosides	99-124	sucrase-isomaltase	Homo sapiens	186-203
6176360-2	1982	Two p-nitrophenyl-alpha-maltaosides are used as substrates, which amylase cleaves to shorter-chain p-nitrophenyl maltaosides, the latter then yielding p-nitrophenol from the activity of alpha-glucosidase.	4-nitrophenol	151-164	sucrase-isomaltase	Homo sapiens	186-203
6803351-0	1982	Effect of the alpha-glucosidase inhibitor, acarbose, on disaccharide splitting enzymes in human dental plaque.	Acarbose	43-51	sucrase-isomaltase	Homo sapiens	14-31
6803351-1	1982	Inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose, sucrose and lactose was carried out with the alpha-glucosidase inhibitor, acarbose.	Maltose	100-107	sucrase-isomaltase	Homo sapiens	154-171
6803351-0	1982	Effect of the alpha-glucosidase inhibitor, acarbose, on disaccharide splitting enzymes in human dental plaque.	Disaccharides	56-68	sucrase-isomaltase	Homo sapiens	14-31
6803351-1	1982	Inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose, sucrose and lactose was carried out with the alpha-glucosidase inhibitor, acarbose.	Sucrose	109-116	sucrase-isomaltase	Homo sapiens	154-171
6803351-1	1982	Inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose, sucrose and lactose was carried out with the alpha-glucosidase inhibitor, acarbose.	Lactose	121-128	sucrase-isomaltase	Homo sapiens	154-171
6803351-1	1982	Inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose, sucrose and lactose was carried out with the alpha-glucosidase inhibitor, acarbose.	Acarbose	183-191	sucrase-isomaltase	Homo sapiens	154-171
6804453-6	1982	The alpha-glucosidase readily hydrolyzed maltose, starch, and glycogen, producing only glucose.	Maltose	41-48	sucrase-isomaltase	Homo sapiens	4-21
7042387-0	1982	Glucose inhibition of the alpha-glucosidase specific for basement membrane and collagen disaccharide units.	Glucose	0-7	sucrase-isomaltase	Homo sapiens	26-43
7042387-0	1982	Glucose inhibition of the alpha-glucosidase specific for basement membrane and collagen disaccharide units.	Disaccharides	88-100	sucrase-isomaltase	Homo sapiens	26-43
7061427-2	1982	Reaction of the carbene with sucrase-isomaltase complex was restricted to a polypeptide segment which is essential for binding the enzyme complex to the native membrane or to liposomes.	carbene	16-23	sucrase-isomaltase	Homo sapiens	29-47
7061427-3	1982	The same labeling selectivity was obtained when purified sucrase-isomaltase complex was labeled either in Triton X-100 solution or when it was incorporated in egg-lecithin liposomes.	Octoxynol	106-118	sucrase-isomaltase	Homo sapiens	57-75
6804453-1	1982	alpha-Glucosidase was extracted from a homogenate of human kidney, initially with 0.02 M Tris-HCl buffer, pH 7.6, and subsequently with a mixture of 0.5% cholate and 0.5% Triton X-100 in the same buffer, pH 7.6.	Tris hydrochloride	89-97	sucrase-isomaltase	Homo sapiens	0-17
6804453-6	1982	The alpha-glucosidase readily hydrolyzed maltose, starch, and glycogen, producing only glucose.	Starch	50-56	sucrase-isomaltase	Homo sapiens	4-21
6804453-1	1982	alpha-Glucosidase was extracted from a homogenate of human kidney, initially with 0.02 M Tris-HCl buffer, pH 7.6, and subsequently with a mixture of 0.5% cholate and 0.5% Triton X-100 in the same buffer, pH 7.6.	Cholates	154-161	sucrase-isomaltase	Homo sapiens	0-17
6804453-1	1982	alpha-Glucosidase was extracted from a homogenate of human kidney, initially with 0.02 M Tris-HCl buffer, pH 7.6, and subsequently with a mixture of 0.5% cholate and 0.5% Triton X-100 in the same buffer, pH 7.6.	Octoxynol	171-183	sucrase-isomaltase	Homo sapiens	0-17
6804453-6	1982	The alpha-glucosidase readily hydrolyzed maltose, starch, and glycogen, producing only glucose.	Glycogen	62-70	sucrase-isomaltase	Homo sapiens	4-21
6804453-6	1982	The alpha-glucosidase readily hydrolyzed maltose, starch, and glycogen, producing only glucose.	Glucose	87-94	sucrase-isomaltase	Homo sapiens	4-21
7160549-2	1982	Carbohydrate malabsorption was induced by the competitive alpha-glucosidase inhibitor, acarbose.	Carbohydrates	0-12	sucrase-isomaltase	Homo sapiens	58-75
6176218-6	1982	The hydrolysis of maltose, trehalose and melezitose confirmed the presence of alpha-glucosidase activity.	Maltose	18-25	sucrase-isomaltase	Homo sapiens	78-95
6176218-6	1982	The hydrolysis of maltose, trehalose and melezitose confirmed the presence of alpha-glucosidase activity.	Trehalose	27-36	sucrase-isomaltase	Homo sapiens	78-95
7160549-2	1982	Carbohydrate malabsorption was induced by the competitive alpha-glucosidase inhibitor, acarbose.	Acarbose	87-95	sucrase-isomaltase	Homo sapiens	58-75
7028558-0	1981	Improvement of metabolic control in insulin dependent diabetics treated with the alpha-glucosidase inhibitor acarbose for two months.	Acarbose	109-117	sucrase-isomaltase	Homo sapiens	81-98
7028558-1	1981	Acarbose, an alpha-glucosidase inhibitor, delays starch digestion and inhibits intestinal sucrase and maltase activity.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
7028558-1	1981	Acarbose, an alpha-glucosidase inhibitor, delays starch digestion and inhibits intestinal sucrase and maltase activity.	Starch	49-55	sucrase-isomaltase	Homo sapiens	13-30
6175886-0	1981	[The effect of neutral urinary alpha-glucosidase on the alpha-amylase determination with maltotetraose as a substrate].	maltotetraose	89-102	sucrase-isomaltase	Homo sapiens	31-48
7286495-0	1981	Long-term treatment of sulphonylurea-treated diabetics with the alpha-glucosidase inhibitor Bay g 5421 (acarbose)	Sulfonylurea Compounds	23-36	sucrase-isomaltase	Homo sapiens	64-81
7286495-0	1981	Long-term treatment of sulphonylurea-treated diabetics with the alpha-glucosidase inhibitor Bay g 5421 (acarbose)	Acarbose	92-102	sucrase-isomaltase	Homo sapiens	64-81
7286495-0	1981	Long-term treatment of sulphonylurea-treated diabetics with the alpha-glucosidase inhibitor Bay g 5421 (acarbose)	Acarbose	104-112	sucrase-isomaltase	Homo sapiens	64-81
7347488-2	1981	Sucrase-isomaltase activity was absent in the three patients, and corresponded with the gel electrophoresis of SDS-solubilized brush border membranes, which failed to demonstrate the protein band normally associated with sucrase-isomaltase complex.	Sodium Dodecyl Sulfate	111-114	sucrase-isomaltase	Homo sapiens	0-18
7018580-6	1981	Neutral alpha-glucosidase AB precipitates at 0-40% (NH4)2SO4, binds to concanavalin A, has a molecular weight of greater than 150 000, and does not utilize alpha 1-4 linked glucose substrates larger than a disaccharide.	Ammonium Sulfate	51-60	sucrase-isomaltase	Homo sapiens	8-25
7018580-6	1981	Neutral alpha-glucosidase AB precipitates at 0-40% (NH4)2SO4, binds to concanavalin A, has a molecular weight of greater than 150 000, and does not utilize alpha 1-4 linked glucose substrates larger than a disaccharide.	Disaccharides	206-218	sucrase-isomaltase	Homo sapiens	8-25
7018580-7	1981	Neutral alpha-glucosidase AB migrates more rapidly to the anode than alpha-glucosidase C when agarose, Cellogel, acrylamide or starch are used as support media.	Sepharose	94-101	sucrase-isomaltase	Homo sapiens	8-25
7018580-7	1981	Neutral alpha-glucosidase AB migrates more rapidly to the anode than alpha-glucosidase C when agarose, Cellogel, acrylamide or starch are used as support media.	acemannan	103-111	sucrase-isomaltase	Homo sapiens	8-25
7018580-7	1981	Neutral alpha-glucosidase AB migrates more rapidly to the anode than alpha-glucosidase C when agarose, Cellogel, acrylamide or starch are used as support media.	Acrylamide	113-123	sucrase-isomaltase	Homo sapiens	8-25
7018580-7	1981	Neutral alpha-glucosidase AB migrates more rapidly to the anode than alpha-glucosidase C when agarose, Cellogel, acrylamide or starch are used as support media.	Starch	127-133	sucrase-isomaltase	Homo sapiens	8-25
6166629-2	1981	We used high-performance liquid chromatography (HPLC) to establish the action pattern of maltoheptaose under the test conditions: (A) the action pattern of alpha-amylase, (B) that of the combined action of alpha-amylase and alpha-glucosidase.	maltoheptaose	89-102	sucrase-isomaltase	Homo sapiens	224-241
6770674-0	1980	An isozyme of acid alpha-glucosidase with reduced catalytic activity for glycogen.	Glycogen	73-81	sucrase-isomaltase	Homo sapiens	19-36
6451798-4	1980	Extracellular levels of beta-hexosaminidase were raised and those of alpha-glucosidase and beta-glucuronidase were lowered when tissue was incubated with 1 microM colchicine, suggesting that microtubules are involved in the control of lysosomal enzyme release from placental villi.	Colchicine	163-173	sucrase-isomaltase	Homo sapiens	69-86
6993048-4	1980	Assuming a 100% location of alpha-glucosidase in the brush border membrane, distribution studies indicated that activities against tetrapeptides and leucyl-2-naphthylamide were located exclusively in the brush border membrane.	leucyl-2-naphthylamide	149-171	sucrase-isomaltase	Homo sapiens	28-45
6769091-4	1980	alpha-Glucosidase activity was measured in water homogenates, water extracts after centrifugation, and Triton extracts, with or without antisera directed against acid maltase (EC 3.2.1.3) and renal maltase (EC 3.2.1.20).	Water	43-48	sucrase-isomaltase	Homo sapiens	0-17
6769091-4	1980	alpha-Glucosidase activity was measured in water homogenates, water extracts after centrifugation, and Triton extracts, with or without antisera directed against acid maltase (EC 3.2.1.3) and renal maltase (EC 3.2.1.20).	Water	62-67	sucrase-isomaltase	Homo sapiens	0-17
6770674-1	1980	Both the common and a variant isozyme of acid alpha-glucosidase have been purified from a heterozygous placenta with CM-Sephadex, ammonium sulfate precipitation, dialysis, Amicon filtration, affinity chromatography by Sephadex G-100, and DEAE-cellulose chromatography.	Ammonium Sulfate	130-146	sucrase-isomaltase	Homo sapiens	46-63
6770674-1	1980	Both the common and a variant isozyme of acid alpha-glucosidase have been purified from a heterozygous placenta with CM-Sephadex, ammonium sulfate precipitation, dialysis, Amicon filtration, affinity chromatography by Sephadex G-100, and DEAE-cellulose chromatography.	sephadex	218-232	sucrase-isomaltase	Homo sapiens	46-63
6770674-1	1980	Both the common and a variant isozyme of acid alpha-glucosidase have been purified from a heterozygous placenta with CM-Sephadex, ammonium sulfate precipitation, dialysis, Amicon filtration, affinity chromatography by Sephadex G-100, and DEAE-cellulose chromatography.	DEAE-Cellulose	238-252	sucrase-isomaltase	Homo sapiens	46-63
385176-3	1979	The relative rates of production of substrates, utilized in the coupled yeast alpha-glucosidase reaction, increased in the order of maltoheptaose, maltohexaose, maltotetraose, and maltopentaose with human pancreatic alpha-amylase, while with human salivary alpha-amylase in the order of maltoheptaose, maltotetraose, maltohexaose, and maltopentaose.	maltoheptaose	132-145	sucrase-isomaltase	Homo sapiens	78-95
94928-1	1979	The author reports a modification of the UV method UltraZyme Plus alpha-Amyl Harleco and the adaptation to the Eppendorf Enzymautomat 5010. alpha-amylase acts on an oligosaccharide mixture yielding maltose, which is hydrolysed by alpha-glucosidase.	Oligosaccharides	165-180	sucrase-isomaltase	Homo sapiens	230-247
94928-1	1979	The author reports a modification of the UV method UltraZyme Plus alpha-Amyl Harleco and the adaptation to the Eppendorf Enzymautomat 5010. alpha-amylase acts on an oligosaccharide mixture yielding maltose, which is hydrolysed by alpha-glucosidase.	Maltose	198-205	sucrase-isomaltase	Homo sapiens	230-247
385176-3	1979	The relative rates of production of substrates, utilized in the coupled yeast alpha-glucosidase reaction, increased in the order of maltoheptaose, maltohexaose, maltotetraose, and maltopentaose with human pancreatic alpha-amylase, while with human salivary alpha-amylase in the order of maltoheptaose, maltotetraose, maltohexaose, and maltopentaose.	maltohexaose	147-159	sucrase-isomaltase	Homo sapiens	78-95
385176-3	1979	The relative rates of production of substrates, utilized in the coupled yeast alpha-glucosidase reaction, increased in the order of maltoheptaose, maltohexaose, maltotetraose, and maltopentaose with human pancreatic alpha-amylase, while with human salivary alpha-amylase in the order of maltoheptaose, maltotetraose, maltohexaose, and maltopentaose.	maltotetraose	161-174	sucrase-isomaltase	Homo sapiens	78-95
385176-3	1979	The relative rates of production of substrates, utilized in the coupled yeast alpha-glucosidase reaction, increased in the order of maltoheptaose, maltohexaose, maltotetraose, and maltopentaose with human pancreatic alpha-amylase, while with human salivary alpha-amylase in the order of maltoheptaose, maltotetraose, maltohexaose, and maltopentaose.	maltoheptaose	287-300	sucrase-isomaltase	Homo sapiens	78-95
385176-3	1979	The relative rates of production of substrates, utilized in the coupled yeast alpha-glucosidase reaction, increased in the order of maltoheptaose, maltohexaose, maltotetraose, and maltopentaose with human pancreatic alpha-amylase, while with human salivary alpha-amylase in the order of maltoheptaose, maltotetraose, maltohexaose, and maltopentaose.	maltohexaose	317-329	sucrase-isomaltase	Homo sapiens	78-95
385176-4	1979	Thus, maltopentaose was considered to be the best substrate over maltotetraose, maltohexaose or maltoheptaose for the alpha-glucosidase coupled method of alpha-amylase determination.	maltohexaose	80-92	sucrase-isomaltase	Homo sapiens	118-135
385176-4	1979	Thus, maltopentaose was considered to be the best substrate over maltotetraose, maltohexaose or maltoheptaose for the alpha-glucosidase coupled method of alpha-amylase determination.	maltoheptaose	96-109	sucrase-isomaltase	Homo sapiens	118-135
375343-0	1979	The effects of the alpha-glucosidase inhibitor BAY g 5421 (Acarbose) on postprandial blood glucose, serum insulin, and triglyceride levels: dose-time-response relationships in man.	Acarbose	47-57	sucrase-isomaltase	Homo sapiens	19-36
314493-6	1979	Moreover these methods need alpha-glucosidase, which degrades maltooligosaccharides consisting of less than seven glucose units, whereas higher polymerized substrates show slower degradation rates by amylase, and the kinetics are not easy to understand.	maltooligosaccharides	62-83	sucrase-isomaltase	Homo sapiens	28-45
314493-6	1979	Moreover these methods need alpha-glucosidase, which degrades maltooligosaccharides consisting of less than seven glucose units, whereas higher polymerized substrates show slower degradation rates by amylase, and the kinetics are not easy to understand.	Glucose	114-121	sucrase-isomaltase	Homo sapiens	28-45
375343-1	1979	In a double-blind quadruple cross-over study the effect of a new alpha-glucosidase inhibitor (BAY g 5421) on postprandial blood glucose, serum insulin, and serum triglyceride increases was tested in 24 male healthy volunteers.	Glucose	128-135	sucrase-isomaltase	Homo sapiens	65-82
391169-2	1979	3.2.1.20) from human seminal plasma, we have shown by ion exchange chromatography, Sephadex G-200 filtration, and adsorption chromatography that this alpha-glucosidase activity corresponded to two isoenzymes having the same ability to hydrolyse p-nitrophenyl-alpha-D-glucopyranoside.	Glucose	265-282	sucrase-isomaltase	Homo sapiens	150-167
365246-0	1979	Hydrolysis of low molecular weight isomaltosaccharides by a p-nitrophenyl-alpha-D-glucopyranoside-hydrolyzing alpha-glucosidase from a thermophile, Bacillus thermoglucosidius KP 1006.	isomaltotriose	35-54	sucrase-isomaltase	Homo sapiens	110-127
365246-0	1979	Hydrolysis of low molecular weight isomaltosaccharides by a p-nitrophenyl-alpha-D-glucopyranoside-hydrolyzing alpha-glucosidase from a thermophile, Bacillus thermoglucosidius KP 1006.	4-nitrophenyl alpha-glucoside	60-97	sucrase-isomaltase	Homo sapiens	110-127
365246-1	1979	A p-nitrophenyl-alpha-D-glucopyranoside-hydrolyzing alpha-glucosidase of a thermophile, Bacillus thermoglucosidius KP 1006, was purified to an electrophoretically-homogeneous state.	4-nitrophenyl alpha-glucoside	2-39	sucrase-isomaltase	Homo sapiens	52-69
31251-1	1978	Activities of two major forms of alpha-glucosidase in cultured amniotic fluid cells have been measured by the 4-methylumbelliferyl-alpha-D-glucoside assay after 3, 6 and 9 weeks of culturing.	4-methylumbelliferyl-alpha-d-glucoside	110-148	sucrase-isomaltase	Homo sapiens	33-50
361294-1	1978	alpha-Glucosidase activity was assayed in polymorphonuclear cells and lymphocytes from human peripheral blood with 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate in the presence of sodium taurocholate.	4-methylumbelliferyl glucoside	115-159	sucrase-isomaltase	Homo sapiens	0-17
361297-5	1978	Another small peak representing alpha-glucosidase was found in fresh extracts of cultured cells on DEAE-cellulose columns.	DEAE-Cellulose	99-113	sucrase-isomaltase	Homo sapiens	32-49
361294-1	1978	alpha-Glucosidase activity was assayed in polymorphonuclear cells and lymphocytes from human peripheral blood with 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate in the presence of sodium taurocholate.	Taurocholic Acid	192-211	sucrase-isomaltase	Homo sapiens	0-17
355131-0	1978	alpha-Glucosidase activities of endometrium, uterine fluids & serum at various physiological conditions.	Adenosine Monophosphate	61-64	sucrase-isomaltase	Homo sapiens	0-17
363174-5	1978	The nature of interaction between acid alpha-glucosidase and immobilized rho-aminophenyl-alpha-glucopyranoside is discussed.	rho-aminophenyl-alpha-glucopyranoside	73-110	sucrase-isomaltase	Homo sapiens	39-56
36061-6	1978	Cervical alpha-glucosidase activity was greater at oestrus than during the rest of the oestrous cycle, declined during early pregnancy, and increased in ovariectomized ewes following the injection of oestradiol-17 beta.	Estradiol	200-218	sucrase-isomaltase	Homo sapiens	9-26
29608-4	1978	alpha-Glucosidase activity sedimented in sucrose density gradients to a point (p = 1.180 g/ml) just above the specific granules, possibly the "tertiary" granule population.	Sucrose	41-48	sucrase-isomaltase	Homo sapiens	0-17
371638-0	1978	[Effect of a bicarbonate-alkaline-earth mineral water on the proteolytic and alpha-glucosidase activity of the gastric mucosa].	Bicarbonates	13-24	sucrase-isomaltase	Homo sapiens	77-94
371638-0	1978	[Effect of a bicarbonate-alkaline-earth mineral water on the proteolytic and alpha-glucosidase activity of the gastric mucosa].	Water	48-53	sucrase-isomaltase	Homo sapiens	77-94
926710-2	1977	In this method after neutral deproteinization the assay is carried out by the hexokinase technique [6--7] after splitting of the maltose with alpha-glucosidase [8].	Maltose	129-136	sucrase-isomaltase	Homo sapiens	142-159
911942-7	1977	The anomeric configuration of glucose produced under the action of alpha-glucosidase on maltose and starch was determined using a kinetic method.	Glucose	30-37	sucrase-isomaltase	Homo sapiens	67-84
911942-7	1977	The anomeric configuration of glucose produced under the action of alpha-glucosidase on maltose and starch was determined using a kinetic method.	Maltose	88-95	sucrase-isomaltase	Homo sapiens	67-84
911942-7	1977	The anomeric configuration of glucose produced under the action of alpha-glucosidase on maltose and starch was determined using a kinetic method.	Starch	100-106	sucrase-isomaltase	Homo sapiens	67-84
1256470-2	1976	Deficiency of sucrase-isomaltase, an intestinal enzyme complex that is essential for digestion of nutritionally important carbohydrates, appears to be inherited as an autosomal recessive in 0.2 per cent of North Americans.	Carbohydrates	122-135	sucrase-isomaltase	Homo sapiens	14-32
560212-0	1977	Stereospecific ring opening of conduritol-B-epoxide by an active site asparatate residue of sucrase-isomaltase.	conduritol epoxide	31-51	sucrase-isomaltase	Homo sapiens	92-110
560212-0	1977	Stereospecific ring opening of conduritol-B-epoxide by an active site asparatate residue of sucrase-isomaltase.	Aspartic Acid	70-80	sucrase-isomaltase	Homo sapiens	92-110
560212-1	1977	Conduritol-B-epoxide inactivates sucrase-isomaltase (sucrose alpha-glucohydrolase, EC 3.2.1.48-dextrin 6-alpha-glucohydrolase, EC 3.2.1.10) irreversibly with incorporation of 1 mol inhibitor/mol subunit, the affinity label being bound in both subunits to a beta-carboxyl group of an aspartic acid (Quaroni, A. and Semnza; G. (1976) J. Biol.	conduritol epoxide	0-20	sucrase-isomaltase	Homo sapiens	33-51
560212-1	1977	Conduritol-B-epoxide inactivates sucrase-isomaltase (sucrose alpha-glucohydrolase, EC 3.2.1.48-dextrin 6-alpha-glucohydrolase, EC 3.2.1.10) irreversibly with incorporation of 1 mol inhibitor/mol subunit, the affinity label being bound in both subunits to a beta-carboxyl group of an aspartic acid (Quaroni, A. and Semnza; G. (1976) J. Biol.	Aspartic Acid	283-296	sucrase-isomaltase	Homo sapiens	33-51
560212-1	1977	Conduritol-B-epoxide inactivates sucrase-isomaltase (sucrose alpha-glucohydrolase, EC 3.2.1.48-dextrin 6-alpha-glucohydrolase, EC 3.2.1.10) irreversibly with incorporation of 1 mol inhibitor/mol subunit, the affinity label being bound in both subunits to a beta-carboxyl group of an aspartic acid (Quaroni, A. and Semnza; G. (1976) J. Biol.	quaroni	298-305	sucrase-isomaltase	Homo sapiens	33-51
17490-5	1977	Decreases in the urinary alpha-glucosidase activity measured at pH 4.0 with added KCl and the ratio of the activity at pH 4.0 with added KCl/the activity at pH 6.5 without KCl may aid in the detection of homozygotes or heterozygotes with the adult form of Pompe"s disease.	Potassium Chloride	82-85	sucrase-isomaltase	Homo sapiens	25-42
848950-1	1977	Addition of 2 mg of Pb2+/g of soil concident with or after amendment with starch or maltose resulted in 75 and 50% decreases in net synthesis of amylase and alpha-glucosidase, respectively.	Maltose	84-91	sucrase-isomaltase	Homo sapiens	157-174
4249-1	1976	A sensitive fluorometric assay utilizing 4-methylumbelliferyl-alpha-D-glucopyranoside has been developed for the determination of alpha-glucosidase.	4-methylumbelliferyl glucoside	41-85	sucrase-isomaltase	Homo sapiens	130-147
191258-4	1977	Plasma alpha-L-fucosidase, alpha-mannosidase, alpha-galactosidase and alpha-glucosidase isoenzymes were eluted at higher salt concentrations than the corresponding liver isoenzymes whereasbeta-N-acetylglucosaminidase, beta-galactosidase, beta-glucosidase, exo-1,4-beta-xylosidase and alpha-L-arabinofuranosidase isoenzymes were eluted at lower salt concentrations.	Salts	121-125	sucrase-isomaltase	Homo sapiens	70-87
191258-4	1977	Plasma alpha-L-fucosidase, alpha-mannosidase, alpha-galactosidase and alpha-glucosidase isoenzymes were eluted at higher salt concentrations than the corresponding liver isoenzymes whereasbeta-N-acetylglucosaminidase, beta-galactosidase, beta-glucosidase, exo-1,4-beta-xylosidase and alpha-L-arabinofuranosidase isoenzymes were eluted at lower salt concentrations.	Salts	344-348	sucrase-isomaltase	Homo sapiens	70-87
1269840-3	1976	Urinary alpha-glu activity in the diabetics shows striking inhibition by glucose, and this may reflect a similar phenomenon in vivo.	Glucose	73-80	sucrase-isomaltase	Homo sapiens	8-17
5913768-0	1966	Effect of glucose on induction of alpha-glucosidase in Candida.	Glucose	10-17	sucrase-isomaltase	Homo sapiens	34-51
1182172-2	1975	Solubilized by either papain or Triton X-100, the sucrase-isomaltase complex is purified in a three-step procedure, including differential centrifugation, Sephadex G-200 and DEAE-cellulose chromatography.	Octoxynol	32-44	sucrase-isomaltase	Homo sapiens	50-68
1182172-2	1975	Solubilized by either papain or Triton X-100, the sucrase-isomaltase complex is purified in a three-step procedure, including differential centrifugation, Sephadex G-200 and DEAE-cellulose chromatography.	sephadex	155-169	sucrase-isomaltase	Homo sapiens	50-68
1182172-2	1975	Solubilized by either papain or Triton X-100, the sucrase-isomaltase complex is purified in a three-step procedure, including differential centrifugation, Sephadex G-200 and DEAE-cellulose chromatography.	2-diethylaminoethanol	174-178	sucrase-isomaltase	Homo sapiens	50-68
4633442-7	1973	Acetate reduced the decline in acid phosphatase activity; acetate and glucose enhanced the recovery of alpha-glucosidase activity; carmine had no effect on intracellular enzyme activities.	Acetates	58-65	sucrase-isomaltase	Homo sapiens	103-120
4633442-7	1973	Acetate reduced the decline in acid phosphatase activity; acetate and glucose enhanced the recovery of alpha-glucosidase activity; carmine had no effect on intracellular enzyme activities.	Glucose	70-77	sucrase-isomaltase	Homo sapiens	103-120
5579867-0	1971	Fructose-free diet effects on intestinal alpha-glucosidase activities in hereditary fructose intolerance.	Fructose	0-8	sucrase-isomaltase	Homo sapiens	41-58
5579867-0	1971	Fructose-free diet effects on intestinal alpha-glucosidase activities in hereditary fructose intolerance.	Fructose	84-92	sucrase-isomaltase	Homo sapiens	41-58
5286578-2	1971	Cortisone causes a marked increase in the activity of liver acid alpha-glucosidase 2h after injection into male Wistar rats.	Cortisone	0-9	sucrase-isomaltase	Homo sapiens	65-82
5286578-4	1971	Cortisone-treated human liver tissue, obtained by needle biopsy, also shows an increase in acid alpha-glucosidase activity.	Cortisone	0-9	sucrase-isomaltase	Homo sapiens	96-113
33711702-0	2021	A new functionality study of vanillin as the inhibitor for alpha-glucosidase and its inhibition kinetic mechanism.	vanillin	29-37	sucrase-isomaltase	Homo sapiens	59-76
4221994-0	1965	Distribution of alpha-glucosidase activities in human & monkey small intestine.	Adenosine Monophosphate	55-58	sucrase-isomaltase	Homo sapiens	16-33
14013482-0	1963	Effect of 6-mercaptopurine on induction of alpha-glucosidase in Candida.	Mercaptopurine	10-26	sucrase-isomaltase	Homo sapiens	43-60
13903834-0	1962	The influence of structure on the hydrolysis of substituted phenyl alpha-D-glucosides by alpha-glucosidase.	substituted phenyl alpha-d-glucosides	48-85	sucrase-isomaltase	Homo sapiens	89-106
34044950-4	2021	The optimally extracted glucomannan- and glucogalactan-containing polysaccharides revealed significant antidiabetic effects through inhibiting alpha-amylase and alpha-glucosidase, improving dynamic insulin sensitivity and secretion, and promoting pancreatic beta-cell proliferation.	(1-6)-alpha-glucomannan	24-35	sucrase-isomaltase	Homo sapiens	161-178
34044950-4	2021	The optimally extracted glucomannan- and glucogalactan-containing polysaccharides revealed significant antidiabetic effects through inhibiting alpha-amylase and alpha-glucosidase, improving dynamic insulin sensitivity and secretion, and promoting pancreatic beta-cell proliferation.	glucogalactan	41-54	sucrase-isomaltase	Homo sapiens	161-178
34044950-4	2021	The optimally extracted glucomannan- and glucogalactan-containing polysaccharides revealed significant antidiabetic effects through inhibiting alpha-amylase and alpha-glucosidase, improving dynamic insulin sensitivity and secretion, and promoting pancreatic beta-cell proliferation.	Polysaccharides	66-81	sucrase-isomaltase	Homo sapiens	161-178
33711702-2	2021	In this work, a new functionality of vanillin as the alpha-glucosidase inhibitor was studied based on the inhibition kinetic mechanism.	vanillin	37-45	sucrase-isomaltase	Homo sapiens	53-70
33711702-3	2021	The inhibitory effect (IC50) of vanillin against alpha-glucosidase was 28.34 +- 0.89 mg/mL, which belongs to mixed inhibition mechanism and its process was spontaneous.	vanillin	32-40	sucrase-isomaltase	Homo sapiens	49-66
33711702-4	2021	Vanillin could bind to alpha-glucosidase by hydrophobic interactions and hydrogen bonds with -8.42 kcal/mol intermolecular energy to form the steric hindrance.	vanillin	0-8	sucrase-isomaltase	Homo sapiens	23-40
33711702-4	2021	Vanillin could bind to alpha-glucosidase by hydrophobic interactions and hydrogen bonds with -8.42 kcal/mol intermolecular energy to form the steric hindrance.	Hydrogen	73-81	sucrase-isomaltase	Homo sapiens	23-40
33711702-6	2021	In addition, the protein secondary structure and denaturation temperature (decreasing about 10  C) were changed significantly after vanillin binding to alpha-glucosidase, resulting in an inhibitory effect.	vanillin	132-140	sucrase-isomaltase	Homo sapiens	152-169
33711702-7	2021	The findings of this research provide insights for the development of vanillin as potential inhibitor for alpha-glucosidase in special dietary foods.	vanillin	70-78	sucrase-isomaltase	Homo sapiens	106-123
33839583-0	2021	Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives as potential alpha-glucosidase inhibitors.	hydrazineylideneindolinone	71-97	sucrase-isomaltase	Homo sapiens	162-179
33476922-0	2021	Comparative study of inhibition mechanisms of structurally different flavonoid compounds on alpha-glucosidase and synergistic effect with acarbose.	Flavonoids	69-78	sucrase-isomaltase	Homo sapiens	92-109
33476922-1	2021	Flavonoid compounds have anti-diabetic activity, which can control blood glucose levels by inhibiting alpha-glucosidase activity.	Flavonoids	0-9	sucrase-isomaltase	Homo sapiens	102-119
33476922-1	2021	Flavonoid compounds have anti-diabetic activity, which can control blood glucose levels by inhibiting alpha-glucosidase activity.	Glucose	73-80	sucrase-isomaltase	Homo sapiens	102-119
33476922-2	2021	In this paper, the inhibition mechanisms between four flavonoid compounds and alpha-glucosidase were studied by multispectroscopic methods and molecular docking.	Flavonoids	54-63	sucrase-isomaltase	Homo sapiens	78-95
33476922-4	2021	Also, the synergistic effects of flavonoid compounds combined with acarbose on inhibiting alpha-glucosidase activity were observed.	Flavonoids	33-42	sucrase-isomaltase	Homo sapiens	90-107
33476922-4	2021	Also, the synergistic effects of flavonoid compounds combined with acarbose on inhibiting alpha-glucosidase activity were observed.	Acarbose	67-75	sucrase-isomaltase	Homo sapiens	90-107
33476922-5	2021	The fluorescence results showed that flavonoid compounds combined with alpha-glucosidase to form a stable complex.	Flavonoids	37-46	sucrase-isomaltase	Homo sapiens	71-88
33476922-7	2021	The present study demonstrated that the molecular structure of flavonoid compounds played an important role in the inhibition process, namely, scutellarein with more hydroxyl groups on the A-ring might serve as the most effective alpha-glucosidase inhibitor.	Flavonoids	63-72	sucrase-isomaltase	Homo sapiens	230-247
33839583-0	2021	Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives as potential alpha-glucosidase inhibitors.	phenoxymethyl-1,2,3-triazole	108-136	sucrase-isomaltase	Homo sapiens	162-179
33839583-1	2021	In this work, a novel series of hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives were designed, synthesized, and evaluated for their anti-alpha-glucosidase activity due to an urgent need to develop effective anti-diabetic agents.	hydrazineylideneindolinone	32-58	sucrase-isomaltase	Homo sapiens	167-184
33839583-1	2021	In this work, a novel series of hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives were designed, synthesized, and evaluated for their anti-alpha-glucosidase activity due to an urgent need to develop effective anti-diabetic agents.	phenoxymethyl-1,2,3-triazole	69-97	sucrase-isomaltase	Homo sapiens	167-184
33992880-7	2021	Interestingly, the different types of components in the herbs exhibited selectivity for different targets: flavanone glycosides are effective on alpha-glucosidase but ineffective on acetylcholinesterase; polymethoxyflavonoids are effective on acetylcholinesterase but ineffective on alpha-glucosidase.	flavanone glycosides	107-127	sucrase-isomaltase	Homo sapiens	145-162
33992880-7	2021	Interestingly, the different types of components in the herbs exhibited selectivity for different targets: flavanone glycosides are effective on alpha-glucosidase but ineffective on acetylcholinesterase; polymethoxyflavonoids are effective on acetylcholinesterase but ineffective on alpha-glucosidase.	flavanone glycosides	107-127	sucrase-isomaltase	Homo sapiens	283-300
31305136-0	2021	Synthesis and inhibition of alpha-glucosidase of methyl glycyrrhetinate glycosides.	methyl glycyrrhetinate glycosides	49-82	sucrase-isomaltase	Homo sapiens	28-45
31305136-3	2021	Compound 1, 2, 7, 12 and glycyrrhizic acid (GL) were evaluated for their inhibitory activities against alpha-glucosidase.	Glycyrrhizic Acid	44-46	sucrase-isomaltase	Homo sapiens	103-120
34047492-0	2021	Dithiocarbamate derivatives inhibit alpha-glucosidase through an apparent allosteric site on the enzyme.	Dithiocarbamate	0-15	sucrase-isomaltase	Homo sapiens	36-53
34047492-6	2021	This is the first report on the allosteric inhibition of alpha-glucosidase by dithiocarbamate derivatives that provides insights into the mechanism of inhibition of the enzyme at molecular level.	Dithiocarbamate	78-93	sucrase-isomaltase	Homo sapiens	57-74
34043318-1	2021	A highly stable and reusable fluorescent multisample nanobiosensor for the detection of alpha-glucosidase inhibitors has been developed by coupling fluorescent liposomal nanoparticles based on conjugated polymers (L-CPNs) to the enzyme alpha-glucosidase, one of the main target enzymes in the treatment of type 2 diabetes.	Polymers	204-212	sucrase-isomaltase	Homo sapiens	88-105
33979163-1	2021	1-Deoxynojirimycin, an alpha-glucosidase inhibitor, possesses various biological activities such as antitumor, antidiabetic, and antiviral effects.	1-Deoxynojirimycin	0-18	sucrase-isomaltase	Homo sapiens	23-40
33979163-4	2021	Among them, compound 10, a conjugate of 1-deoxynojirimycin and kaempferol linked through an undecane chain, exhibited excellent lipophilicity, antiproliferative effects, and alpha-glucosidase inhibitory activity.	1-Deoxynojirimycin	40-58	sucrase-isomaltase	Homo sapiens	174-191
33979163-4	2021	Among them, compound 10, a conjugate of 1-deoxynojirimycin and kaempferol linked through an undecane chain, exhibited excellent lipophilicity, antiproliferative effects, and alpha-glucosidase inhibitory activity.	kaempferol	63-73	sucrase-isomaltase	Homo sapiens	174-191
34043318-1	2021	A highly stable and reusable fluorescent multisample nanobiosensor for the detection of alpha-glucosidase inhibitors has been developed by coupling fluorescent liposomal nanoparticles based on conjugated polymers (L-CPNs) to the enzyme alpha-glucosidase, one of the main target enzymes in the treatment of type 2 diabetes.	Polymers	204-212	sucrase-isomaltase	Homo sapiens	236-253
34043318-1	2021	A highly stable and reusable fluorescent multisample nanobiosensor for the detection of alpha-glucosidase inhibitors has been developed by coupling fluorescent liposomal nanoparticles based on conjugated polymers (L-CPNs) to the enzyme alpha-glucosidase, one of the main target enzymes in the treatment of type 2 diabetes.	l-cpns	214-220	sucrase-isomaltase	Homo sapiens	88-105
34043318-1	2021	A highly stable and reusable fluorescent multisample nanobiosensor for the detection of alpha-glucosidase inhibitors has been developed by coupling fluorescent liposomal nanoparticles based on conjugated polymers (L-CPNs) to the enzyme alpha-glucosidase, one of the main target enzymes in the treatment of type 2 diabetes.	l-cpns	214-220	sucrase-isomaltase	Homo sapiens	236-253
34013660-0	2021	Biological evaluation the 2-aryl-2,3-dihydrobenzodiazaborinin-4(1H)-ones as potential dual alpha-glucosidase and alpha-amylase inhibitors with antioxidant properties.	2-aryl-2,3-dihydrobenzodiazaborinin-4(1h)-ones	26-72	sucrase-isomaltase	Homo sapiens	91-108
34048830-0	2021	New alkaloids from the noni juice with potential alpha-glucosidase inhibitory activity.	Alkaloids	4-13	sucrase-isomaltase	Homo sapiens	49-66
34029582-4	2021	Bioactivity assays implied that the four BPs showed that the polysaccharides (Hw and Na) with higher molecular weight had stronger antioxidant and alpha-glucosidase inhibitory activity.	Polysaccharides	61-76	sucrase-isomaltase	Homo sapiens	147-164
34029582-4	2021	Bioactivity assays implied that the four BPs showed that the polysaccharides (Hw and Na) with higher molecular weight had stronger antioxidant and alpha-glucosidase inhibitory activity.	Histidinyl-Tryptophan	78-80	sucrase-isomaltase	Homo sapiens	147-164
34013660-1	2021	The 2-aryl-2,3-dihydrobenzodiazaborinin-4(1H)-ones (azaborininone) were synthesized as analogues of the 2-arylquinazoline-40ones and screened through enzymatic assay in vitro for inhibitory effect against alpha-glucosidase and alpha-amylase activities.	azaborininone	52-65	sucrase-isomaltase	Homo sapiens	205-222
34013660-1	2021	The 2-aryl-2,3-dihydrobenzodiazaborinin-4(1H)-ones (azaborininone) were synthesized as analogues of the 2-arylquinazoline-40ones and screened through enzymatic assay in vitro for inhibitory effect against alpha-glucosidase and alpha-amylase activities.	2-aryl-2,3-dihydrobenzodiazaborinin-4(1h)-ones	4-50	sucrase-isomaltase	Homo sapiens	205-222
33926423-9	2021	Of the patients with a triple combination of oral OADs (n = 3859), we found that those treated with MET, SU and TZD had a lower risk of AECOPD (adjusted OR 0.81 (0.68-0.96, P = 0.01) than a combination of MET, SU and alpha-glucosidase inhibitors (AGIs) regardless of the level of COPD complexity.	Sulfonylurea Compounds	105-107	sucrase-isomaltase	Homo sapiens	217-234
34003592-6	2021	These supramolecular hydrogels underwent gel-to-sol phase transition upon the addition of alpha-glucosidase as a result of the alpha-glucosidase-catalyzed hydrolysis of the maltose moiety of the amphipathic urea.	Maltose	173-180	sucrase-isomaltase	Homo sapiens	90-107
34003592-6	2021	These supramolecular hydrogels underwent gel-to-sol phase transition upon the addition of alpha-glucosidase as a result of the alpha-glucosidase-catalyzed hydrolysis of the maltose moiety of the amphipathic urea.	Maltose	173-180	sucrase-isomaltase	Homo sapiens	127-144
33515684-0	2021	Polyphenol-rich extract and fractions of Terminalia phaeocarpa Eichler possess hypoglycemic effect, reduce the release of cytokines, and inhibit lipase, alpha-glucosidase, and alpha-amilase enzymes.	Polyphenols	0-10	sucrase-isomaltase	Homo sapiens	153-170
33515684-6	2021	AIM OF THE STUDY: investigate the hypoglycaemic effect of an ethanol extract (EE) of T. phaeocarpa leaves and its ethyl acetate (FrEtOAc) and hydromethanolic (FrMEOH) fractions, in addition to their activity on the release of pro-inflammatory mediators and inhibition of lipase, alpha-amylase, and alpha-glucosidase enzymes.	Ethanol	61-68	sucrase-isomaltase	Homo sapiens	298-315
33950796-0	2021	Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and alpha-glucosidase inhibitors.	Sulfamethazine	22-36	sucrase-isomaltase	Homo sapiens	114-131
33950796-2	2021	Inhibition of metabolic enzymes such as cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and alpha-glucosidase (alpha-GLY) is one of the accepted approaches in the treatment of Alzheimer"s disease (AD) and diabetes mellitus (DM).	Glycine	152-155	sucrase-isomaltase	Homo sapiens	127-144
33939580-0	2021	A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities.	Flavonoids	6-15	sucrase-isomaltase	Homo sapiens	65-82
33939580-3	2021	In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM).	ethyl acetate	43-48	sucrase-isomaltase	Homo sapiens	3-20
33939580-3	2021	In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM).	flavone	65-72	sucrase-isomaltase	Homo sapiens	3-20
33939580-3	2021	In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM).	biflavone	77-86	sucrase-isomaltase	Homo sapiens	3-20
33939580-4	2021	Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities.	Flavones	0-8	sucrase-isomaltase	Homo sapiens	74-91
33939580-4	2021	Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities.	biflavones	13-23	sucrase-isomaltase	Homo sapiens	74-91
33939580-4	2021	Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities.	flavone glycosides	47-65	sucrase-isomaltase	Homo sapiens	74-91
34022705-0	2021	alpha-glucosidase immobilization on magnetic core-shell metal-organic frameworks for inhibitor screening from traditional Chinese medicines.	Metals	56-61	sucrase-isomaltase	Homo sapiens	0-17
34022705-2	2021	For alpha-glucosidase immobilization, magnetic core-shell metal-organic frameworks composite (Fe3O4@CS@ZIF-8) was fabricated by a step-by-step assembly method, and alpha-glucosidase was in situ encapsulated in crystal lattice of ZIF-8.	Metals	58-63	sucrase-isomaltase	Homo sapiens	4-21
34022705-2	2021	For alpha-glucosidase immobilization, magnetic core-shell metal-organic frameworks composite (Fe3O4@CS@ZIF-8) was fabricated by a step-by-step assembly method, and alpha-glucosidase was in situ encapsulated in crystal lattice of ZIF-8.	Metals	58-63	sucrase-isomaltase	Homo sapiens	164-181
34022705-2	2021	For alpha-glucosidase immobilization, magnetic core-shell metal-organic frameworks composite (Fe3O4@CS@ZIF-8) was fabricated by a step-by-step assembly method, and alpha-glucosidase was in situ encapsulated in crystal lattice of ZIF-8.	ferryl iron	94-99	sucrase-isomaltase	Homo sapiens	4-21
34022705-2	2021	For alpha-glucosidase immobilization, magnetic core-shell metal-organic frameworks composite (Fe3O4@CS@ZIF-8) was fabricated by a step-by-step assembly method, and alpha-glucosidase was in situ encapsulated in crystal lattice of ZIF-8.	ferryl iron	94-99	sucrase-isomaltase	Homo sapiens	164-181
34022705-2	2021	For alpha-glucosidase immobilization, magnetic core-shell metal-organic frameworks composite (Fe3O4@CS@ZIF-8) was fabricated by a step-by-step assembly method, and alpha-glucosidase was in situ encapsulated in crystal lattice of ZIF-8.	Cesium	100-102	sucrase-isomaltase	Homo sapiens	4-21
34022705-2	2021	For alpha-glucosidase immobilization, magnetic core-shell metal-organic frameworks composite (Fe3O4@CS@ZIF-8) was fabricated by a step-by-step assembly method, and alpha-glucosidase was in situ encapsulated in crystal lattice of ZIF-8.	Cesium	100-102	sucrase-isomaltase	Homo sapiens	164-181
34022705-7	2021	Among the commercially available 10 components presented in Rhei Radix et Rhizoma, gallic acid, (+)-catechin and epicatechin exhibited the strongest inhibitory effect on alpha-glucosidase.	Gallic Acid	83-94	sucrase-isomaltase	Homo sapiens	170-187
34022705-7	2021	Among the commercially available 10 components presented in Rhei Radix et Rhizoma, gallic acid, (+)-catechin and epicatechin exhibited the strongest inhibitory effect on alpha-glucosidase.	Catechin	100-108	sucrase-isomaltase	Homo sapiens	170-187
34022705-7	2021	Among the commercially available 10 components presented in Rhei Radix et Rhizoma, gallic acid, (+)-catechin and epicatechin exhibited the strongest inhibitory effect on alpha-glucosidase.	Catechin	113-124	sucrase-isomaltase	Homo sapiens	170-187
33946137-3	2021	Furthermore, we compared the interaction of 1-DNJ and glucose molecules with the alpha-glucosidase enzyme, which has a critical role in the lysis of glucose-based polymers in human cells.	Glucose	54-61	sucrase-isomaltase	Homo sapiens	81-98
33946137-3	2021	Furthermore, we compared the interaction of 1-DNJ and glucose molecules with the alpha-glucosidase enzyme, which has a critical role in the lysis of glucose-based polymers in human cells.	Glucose	149-156	sucrase-isomaltase	Homo sapiens	81-98
33946137-15	2021	Docking results showed that 1-DNJ binds more efficiently, and with a significant score than glucose, to human alpha-glucosidase.	Glucose	92-99	sucrase-isomaltase	Homo sapiens	110-127
31204495-0	2021	Synthesis, alpha-Glucosidase inhibition and molecular docking studies of tyrosol derivatives.	4-hydroxyphenylethanol	73-80	sucrase-isomaltase	Homo sapiens	11-28
31204495-1	2021	To find a potent alpha-glucosidase inhibitor, 24 tyrosol derivatives with different substituents located at the meta, ortho, or para position of the phenyl group have been synthesised via the Mitsunobu reaction, characterised by 1H NMR, 13C NMR, ESI-MS and IR and evaluated for inhibition.	4-hydroxyphenylethanol	49-56	sucrase-isomaltase	Homo sapiens	17-34
31204495-1	2021	To find a potent alpha-glucosidase inhibitor, 24 tyrosol derivatives with different substituents located at the meta, ortho, or para position of the phenyl group have been synthesised via the Mitsunobu reaction, characterised by 1H NMR, 13C NMR, ESI-MS and IR and evaluated for inhibition.	Hydrogen	229-231	sucrase-isomaltase	Homo sapiens	17-34
33926423-9	2021	Of the patients with a triple combination of oral OADs (n = 3859), we found that those treated with MET, SU and TZD had a lower risk of AECOPD (adjusted OR 0.81 (0.68-0.96, P = 0.01) than a combination of MET, SU and alpha-glucosidase inhibitors (AGIs) regardless of the level of COPD complexity.	Thiazolidinediones	112-115	sucrase-isomaltase	Homo sapiens	217-234
33721816-8	2021	The developed platform mentioned above facilitated rapid identification of four alpha-glucosidase inhibitors, namely, N-p-trans-coumaroyltyramine (1), N-trans-caffeoyl-tyramine (2), (9R,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3a), and (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3b) from Cortex Lycii.	N-coumaroyltyramine	118-145	sucrase-isomaltase	Homo sapiens	80-97
33900340-5	2021	The alpha-glucosidase inhibitory activity of PPW-1 (IC50 = 2.2 +- 0.1 mg mL-1) is significantly (P < 0.01) higher than those of PP80 (IC50 = 13.1 +- 0.5 mg mL-1) and acarbose (IC50 = 4.3 +- 0.2 mg mL-1), behaving in a non-competitive inhibition manner.	Acarbose	166-174	sucrase-isomaltase	Homo sapiens	4-21
33878390-0	2021	Immobilized lipase catalytic synthesis of phenolamides and their potential against alpha-glucosidase.	phenolamides	42-54	sucrase-isomaltase	Homo sapiens	83-100
33878390-7	2021	The bioassay results indicated that N-trans-caffeoyltyramine and N-trans-feruloyltyramine had potent activities against alpha-glucosidase with IC50 of 30.08 muM and 31.94 muM, respectively.	N-caffeoyltyramine	36-60	sucrase-isomaltase	Homo sapiens	120-137
33878390-7	2021	The bioassay results indicated that N-trans-caffeoyltyramine and N-trans-feruloyltyramine had potent activities against alpha-glucosidase with IC50 of 30.08 muM and 31.94 muM, respectively.	feruloyltyramine	65-89	sucrase-isomaltase	Homo sapiens	120-137
33721816-8	2021	The developed platform mentioned above facilitated rapid identification of four alpha-glucosidase inhibitors, namely, N-p-trans-coumaroyltyramine (1), N-trans-caffeoyl-tyramine (2), (9R,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3a), and (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3b) from Cortex Lycii.	Nitrogen	118-120	sucrase-isomaltase	Homo sapiens	80-97
33721816-8	2021	The developed platform mentioned above facilitated rapid identification of four alpha-glucosidase inhibitors, namely, N-p-trans-coumaroyltyramine (1), N-trans-caffeoyl-tyramine (2), (9R,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3a), and (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3b) from Cortex Lycii.	-caffeoyl-tyramine	158-176	sucrase-isomaltase	Homo sapiens	80-97
33721816-8	2021	The developed platform mentioned above facilitated rapid identification of four alpha-glucosidase inhibitors, namely, N-p-trans-coumaroyltyramine (1), N-trans-caffeoyl-tyramine (2), (9R,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3a), and (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3b) from Cortex Lycii.	9(R)-HODE	182-231	sucrase-isomaltase	Homo sapiens	80-97
33721816-8	2021	The developed platform mentioned above facilitated rapid identification of four alpha-glucosidase inhibitors, namely, N-p-trans-coumaroyltyramine (1), N-trans-caffeoyl-tyramine (2), (9R,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3a), and (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (3b) from Cortex Lycii.	9(S)-HODE	242-291	sucrase-isomaltase	Homo sapiens	80-97
33721816-11	2021	In short, the presented work identified compounds 3a and 3b as potential alpha-glucosidase inhibitors with higher inhibitory activity and a different mode of inhibition compared to the standard alpha-glucosidase inhibitor, acarbose.	Acarbose	223-231	sucrase-isomaltase	Homo sapiens	73-90
33721816-11	2021	In short, the presented work identified compounds 3a and 3b as potential alpha-glucosidase inhibitors with higher inhibitory activity and a different mode of inhibition compared to the standard alpha-glucosidase inhibitor, acarbose.	Acarbose	223-231	sucrase-isomaltase	Homo sapiens	194-211
33538053-0	2021	alpha-Glucosidase Inhibition by Usnic Acid Derivatives.	usnic acid	32-42	sucrase-isomaltase	Homo sapiens	0-17
33609917-0	2021	Quinazolinone-dihydropyrano[3,2-b]pyran hybrids as new alpha-glucosidase inhibitors: Design, synthesis, enzymatic inhibition, docking study and prediction of pharmacokinetic.	quinazolinone-dihydropyrano[3,2-b]pyran	0-39	sucrase-isomaltase	Homo sapiens	55-72
33609917-1	2021	A series of new quinazolinone-dihydropyrano[3,2-b]pyran derivatives 10A-L were synthesized by simple chemical reactions and were investigated for inhibitory activities against alpha-glucosidase and alpha-amylase.	quinazolinone-dihydropyrano[3,2-b]pyran	16-55	sucrase-isomaltase	Homo sapiens	176-193
33601140-0	2021	Synthesis, in vitro and computational studies of novel glycosyl-1, 2, 3-1H-triazolyl methyl benzamide derivatives as potential alpha-glucosidase inhibitory activity.	glycosyl-1, 2, 3-1h-triazolyl methyl benzamide	55-101	sucrase-isomaltase	Homo sapiens	127-144
33601140-1	2021	A series of novel glycosyl-1,2,3-1H-triazolyl methyl benzamide analogues were synthesized by the unambiguous strategy and evaluated for alpha-glucosidase inhibitory activity.	glycosyl-1,2,3-1h-triazolyl methyl benzamide	18-62	sucrase-isomaltase	Homo sapiens	136-153
33601140-2	2021	Glycosyl benzamide exhibited a dose-dependent inhibition of alpha-glucosidase activity.	glycosyl benzamide	0-18	sucrase-isomaltase	Homo sapiens	60-77
33601140-3	2021	The In-vitro alpha-glucosidase inhibition activity results indicated that all the synthesized triazolyl methyl benzamide compounds (IC50 values ranging from 25.3 +- 0.8 to 118.5 +- 5.3 muM) exhibited more inhibitory activity in comparison with the standard drug acarbose (IC50 = 750.0 +- 12.5 muM).	triazolyl methyl benzamide	94-120	sucrase-isomaltase	Homo sapiens	13-30
33601140-3	2021	The In-vitro alpha-glucosidase inhibition activity results indicated that all the synthesized triazolyl methyl benzamide compounds (IC50 values ranging from 25.3 +- 0.8 to 118.5 +- 5.3 muM) exhibited more inhibitory activity in comparison with the standard drug acarbose (IC50 = 750.0 +- 12.5 muM).	Acarbose	262-270	sucrase-isomaltase	Homo sapiens	13-30
33601140-4	2021	Among all, the 3 deacetylated glycosyl methyl benzamide derivatives (4c, 4d and 4f) showed promising alpha-glucosidase enzyme inhibitory activities with IC50 value 25.3 +- 0.8, 26.1 +- 1.5 and 30.6 +- 2.1 respectively.	glycosyl methyl benzamide	30-55	sucrase-isomaltase	Homo sapiens	101-118
33508679-0	2021	Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of alpha-glucosidase enzyme along with in silico study.	indole-based-thiadiazole	13-37	sucrase-isomaltase	Homo sapiens	75-92
33368871-0	2021	Synthesis and biological evaluation of a new series of benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides as potential alpha-glucosidase inhibitors.	benzofuran-1,3,4-oxadiazole	55-82	sucrase-isomaltase	Homo sapiens	133-150
33368871-0	2021	Synthesis and biological evaluation of a new series of benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides as potential alpha-glucosidase inhibitors.	Triazoles	94-108	sucrase-isomaltase	Homo sapiens	133-150
33368871-0	2021	Synthesis and biological evaluation of a new series of benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides as potential alpha-glucosidase inhibitors.	Acetamides	109-119	sucrase-isomaltase	Homo sapiens	133-150
33368871-1	2021	A series of new benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides 12a-n as potential anti-alpha-glucosidase agents were designed and synthesized.	benzofuran-1,3,4-oxadiazole	16-43	sucrase-isomaltase	Homo sapiens	105-122
33368871-1	2021	A series of new benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides 12a-n as potential anti-alpha-glucosidase agents were designed and synthesized.	1,2,3-triazole-acetamides	55-80	sucrase-isomaltase	Homo sapiens	105-122
33368871-1	2021	A series of new benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides 12a-n as potential anti-alpha-glucosidase agents were designed and synthesized.	12a-n	81-86	sucrase-isomaltase	Homo sapiens	105-122
33368871-2	2021	alpha-Glucosidase inhibition assay demonstrated that all the synthesized compounds 12a-n (half-maximal inhibitory concentration [IC50 ] values in the range of 40.7 +- 0.3-173.6 +- 1.9 muM) were more potent than standard inhibitor acarbose (IC50  = 750.0 +- 12.5 microM).	12a-n	83-88	sucrase-isomaltase	Homo sapiens	0-17
33368871-2	2021	alpha-Glucosidase inhibition assay demonstrated that all the synthesized compounds 12a-n (half-maximal inhibitory concentration [IC50 ] values in the range of 40.7 +- 0.3-173.6 +- 1.9 muM) were more potent than standard inhibitor acarbose (IC50  = 750.0 +- 12.5 microM).	Acarbose	230-238	sucrase-isomaltase	Homo sapiens	0-17
33789649-10	2021	The same extract was the most potent inhibitor of alpha-amylase and alpha-glucosidase, with IC50 values of 19.1 +- 0.7 mug/ml and 54.9 +- 0.3 mug/ml, respectively, compared to 28.8, 37.1 +- 0.3 mug/ml of acarbose, respectively.	Acarbose	204-212	sucrase-isomaltase	Homo sapiens	68-85
33621797-0	2021	Dopamine-polyethyleneimine co-deposition cellulose filter paper for alpha-Glucosidase immobilization and enzyme inhibitor screening.	Dopamine	0-8	sucrase-isomaltase	Homo sapiens	68-85
33621797-0	2021	Dopamine-polyethyleneimine co-deposition cellulose filter paper for alpha-Glucosidase immobilization and enzyme inhibitor screening.	aziridine	9-26	sucrase-isomaltase	Homo sapiens	68-85
33621797-1	2021	In this work, cellulose filter paper (CFP), which is inexpensive and commercially available, was used as the carrier, and the immobilized alpha-glucosidase was obtained by two steps: firstly, the surface of CFP was modified by polydopamine/polyethyleneimine (PDA/PEI) co-deposition method to obtain CFP-PDA/PEI with a uniform coating of rich positive charge; subsequently, alpha-glucosidase was immobilized on the CFP-PDA/PEI by electrostatic adsorption.	polydopamine	227-239	sucrase-isomaltase	Homo sapiens	138-155
33621797-1	2021	In this work, cellulose filter paper (CFP), which is inexpensive and commercially available, was used as the carrier, and the immobilized alpha-glucosidase was obtained by two steps: firstly, the surface of CFP was modified by polydopamine/polyethyleneimine (PDA/PEI) co-deposition method to obtain CFP-PDA/PEI with a uniform coating of rich positive charge; subsequently, alpha-glucosidase was immobilized on the CFP-PDA/PEI by electrostatic adsorption.	aziridine	240-257	sucrase-isomaltase	Homo sapiens	138-155
33621797-1	2021	In this work, cellulose filter paper (CFP), which is inexpensive and commercially available, was used as the carrier, and the immobilized alpha-glucosidase was obtained by two steps: firstly, the surface of CFP was modified by polydopamine/polyethyleneimine (PDA/PEI) co-deposition method to obtain CFP-PDA/PEI with a uniform coating of rich positive charge; subsequently, alpha-glucosidase was immobilized on the CFP-PDA/PEI by electrostatic adsorption.	pei	263-266	sucrase-isomaltase	Homo sapiens	138-155
33035857-0	2021	Structural characterization, alpha-amylase and alpha-glucosidase inhibitory activities of polysaccharides from wheat bran.	Polysaccharides	90-105	sucrase-isomaltase	Homo sapiens	47-64
33715179-2	2021	alpha-Glucosidase can hydrolyze carbohydrates to monosaccharides after meals and lead to the rise of blood glucose levels in human body.	Carbohydrates	32-45	sucrase-isomaltase	Homo sapiens	0-17
33715179-2	2021	alpha-Glucosidase can hydrolyze carbohydrates to monosaccharides after meals and lead to the rise of blood glucose levels in human body.	Monosaccharides	49-64	sucrase-isomaltase	Homo sapiens	0-17
33715179-2	2021	alpha-Glucosidase can hydrolyze carbohydrates to monosaccharides after meals and lead to the rise of blood glucose levels in human body.	Glucose	107-114	sucrase-isomaltase	Homo sapiens	0-17
33715179-8	2021	Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data.	Rutin	157-162	sucrase-isomaltase	Homo sapiens	72-89
33715179-8	2021	Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data.	taxifolin	164-173	sucrase-isomaltase	Homo sapiens	72-89
33715179-8	2021	Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data.	Quercetin	175-184	sucrase-isomaltase	Homo sapiens	72-89
33715179-8	2021	Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data.	Chlorogenic Acid	189-205	sucrase-isomaltase	Homo sapiens	72-89
33658478-0	2021	Effects of alpha-glucosidase-inhibiting drugs on acute postprandial glucose and insulin responses: a systematic review and meta-analysis.	Glucose	68-75	sucrase-isomaltase	Homo sapiens	11-28
33658478-2	2021	We performed a systematic review and meta-analysis to quantify effects of alpha-glucosidase-inhibiting (AGI) drugs on acute PPG and PPI responses.	ppg	124-127	sucrase-isomaltase	Homo sapiens	74-91
33581666-6	2021	Compound 6k was the most potent alpha-glucosidase inhibitor with IC50 = 54.25 +- 0.67 microM as compared to reference drug acarbose (IC50 = 375.82 +- 1.76 microM).	Acarbose	123-131	sucrase-isomaltase	Homo sapiens	32-49
33508679-1	2021	A series of nineteen (1-19) indole-based-thiadiazole derivatives were synthesized, characterized by 1HNMR, 13C NMR, MS, and screened for alpha-glucosidase inhibition.	indole-based-thiadiazole	28-52	sucrase-isomaltase	Homo sapiens	137-154
33506699-0	2021	Synthesis and studies of thiazolidinedione-isatin hybrids as alpha-glucosidase inhibitors for management of diabetes.	thiazolidinedione-isatin	25-49	sucrase-isomaltase	Homo sapiens	61-78
33107197-4	2021	In this study we evaluated alpha-glucosidase inhibitory effects 20 azole derivatives selected out of an in-house collection via structure-based virtual screening (VS) with consensus scoring approach.	Azoles	67-72	sucrase-isomaltase	Homo sapiens	27-44
33107197-5	2021	Seven compounds were identified with better IC50 values than acarbose (IC50 = 68.18 +- 1.01 microM), a well-known alpha-glucosidase inhibitor drug, which meant 35% success for our VS methodology.	Acarbose	61-69	sucrase-isomaltase	Homo sapiens	114-131
33449919-1	2021	Aims: The alpha-glucosidase inhibitor acarbose is believed to reduce plasma glucose by delaying hydrolysis of carbohydrates.	Acarbose	38-46	sucrase-isomaltase	Homo sapiens	10-27
33449919-1	2021	Aims: The alpha-glucosidase inhibitor acarbose is believed to reduce plasma glucose by delaying hydrolysis of carbohydrates.	Glucose	76-83	sucrase-isomaltase	Homo sapiens	10-27
33449919-1	2021	Aims: The alpha-glucosidase inhibitor acarbose is believed to reduce plasma glucose by delaying hydrolysis of carbohydrates.	Carbohydrates	110-123	sucrase-isomaltase	Homo sapiens	10-27
33107197-0	2021	Discovery of potent alpha-glucosidase inhibitors through structure-based virtual screening of an in-house azole collection.	Azoles	106-111	sucrase-isomaltase	Homo sapiens	20-37
33506699-1	2021	Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures.	2,4-thiazolidinedione	106-123	sucrase-isomaltase	Homo sapiens	70-87
33506699-1	2021	Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures.	Isatin	124-130	sucrase-isomaltase	Homo sapiens	70-87
33717048-6	2021	These p-terphenyls especially those with 4,2",4""-trihydroxy (4-7, 20, 21) or 4, 4""-dihydroxy-1,2,1",2"-furan (15, 16) substituted nucleus, exhibited significant antioxidant and alpha-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells.	p-terphenyls	6-18	sucrase-isomaltase	Homo sapiens	179-196
33191127-0	2021	Inhibitory potential of 4-hexylresorcinol against alpha-glucosidase and non-enzymatic glycation: Activity and mechanism.	Hexylresorcinol	24-41	sucrase-isomaltase	Homo sapiens	50-67
33191127-2	2021	In this study, we investigated the inhibitory potential and mechanism of 4-hexylresorcinol against alpha-glucosidase and non-enzymatic glycation by using multispectroscopic analyses and molecular docking.	Hexylresorcinol	73-90	sucrase-isomaltase	Homo sapiens	99-116
33191127-3	2021	The results of enzyme kinetics showed that 4-hexylresorcinol reversibly inhibited alpha-glucosidase activity in a noncompetitive way.	Hexylresorcinol	43-60	sucrase-isomaltase	Homo sapiens	82-99
33191127-4	2021	Fluorescence quenching then revealed that it increased the hydrophobicity of alpha-glucosidase and changed the conformation of the enzyme by forming the alpha-glucosidase-hexylresorcinol complex.	Hexylresorcinol	171-186	sucrase-isomaltase	Homo sapiens	77-94
33191127-4	2021	Fluorescence quenching then revealed that it increased the hydrophobicity of alpha-glucosidase and changed the conformation of the enzyme by forming the alpha-glucosidase-hexylresorcinol complex.	Hexylresorcinol	171-186	sucrase-isomaltase	Homo sapiens	153-170
33191127-5	2021	Thermodynamic analysis and molecular docking further demonstrated that the inhibition of 4-hexylresorcinol on the alpha-glucosidase was mainly dependent on hydrogen bond and hydrophobic interaction.	Hexylresorcinol	89-106	sucrase-isomaltase	Homo sapiens	114-131
33191127-5	2021	Thermodynamic analysis and molecular docking further demonstrated that the inhibition of 4-hexylresorcinol on the alpha-glucosidase was mainly dependent on hydrogen bond and hydrophobic interaction.	Hydrogen	156-164	sucrase-isomaltase	Homo sapiens	114-131
33379009-0	2021	Dual electrophoretically-mediated microanalysis in multiple injection mode for the simultaneous determination of acetylcholinesterase and alpha-glucosidase activity applied to selected polyphenols.	Polyphenols	185-196	sucrase-isomaltase	Homo sapiens	138-155
32818865-6	2021	Furthermore, AgNPs-Iso showed the lower erythrocytes hemolysis ratio and cytotoxicity, and exhibited a notably inhibitive effect on alpha-glucosidase and pancreatic lipase.	agnps-iso	13-22	sucrase-isomaltase	Homo sapiens	132-149
33593208-4	2022	Compounds 3 (IC50 59.61 microM) and 5 (IC50 39.52 microM) were identified as active alpha-glucosidase inhibitors, each respectively being 24 and 37 folds more potent than the standard inhibitor, acarbose.	Acarbose	195-203	sucrase-isomaltase	Homo sapiens	84-101
33593208-5	2022	Based on the molecular docking studies, compounds 3 and 5 docked into the active site of the alpha-glucosidase enzyme, forming mainly hydrogen bonds in the active site.	Hydrogen	134-142	sucrase-isomaltase	Homo sapiens	93-110
33583331-6	2021	The virtual screening, drug-likeness property, and ADMET studies, and molecular dynamics simulations carried out reveal Newbouldiaquinone A, Foetidin, Chamuvaritin, Cajaflavanone, and Azadirolic acid as potential inhibitors of alpha-amylase while Chamuvaritin, Newbouldiaquinone A, Flowerone, Scoparic acid A and Nimonol were potential inhibitors of alpha-glucosidase enzyme.	Newbouldiaquinone	120-137	sucrase-isomaltase	Homo sapiens	350-367
33672038-0	2021	Synthesis of Rottlerone Analogues and Evaluation of Their alpha-Glucosidase and DPP-4 Dual Inhibitory and Glucose Consumption-Promoting Activity.	Rottlerone	13-23	sucrase-isomaltase	Homo sapiens	58-75
33672038-1	2021	Our previous study found that desmethylxanthohumol (1) inhibited alpha-glucosidase in vitro.	xanthohumol	30-50	sucrase-isomaltase	Homo sapiens	65-82
33672038-2	2021	Recently, further investigations revealed that dehydrocyclodesmethylxanthohumol (2) and its dimer analogue rottlerone (3) exhibited more potent alpha-glucosidase inhibitory activity than 1.	dehydrocyclodesmethylxanthohumol	47-79	sucrase-isomaltase	Homo sapiens	144-161
33672038-2	2021	Recently, further investigations revealed that dehydrocyclodesmethylxanthohumol (2) and its dimer analogue rottlerone (3) exhibited more potent alpha-glucosidase inhibitory activity than 1.	Rottlerone	107-117	sucrase-isomaltase	Homo sapiens	144-161
33672038-3	2021	The aim of this study was to synthesize a series of rottlerone analogues and evaluate their alpha-glucosidase and DPP-4 dual inhibitory activity.	Rottlerone	52-62	sucrase-isomaltase	Homo sapiens	92-109
33583331-6	2021	The virtual screening, drug-likeness property, and ADMET studies, and molecular dynamics simulations carried out reveal Newbouldiaquinone A, Foetidin, Chamuvaritin, Cajaflavanone, and Azadirolic acid as potential inhibitors of alpha-amylase while Chamuvaritin, Newbouldiaquinone A, Flowerone, Scoparic acid A and Nimonol were potential inhibitors of alpha-glucosidase enzyme.	foetidin	141-149	sucrase-isomaltase	Homo sapiens	350-367
33583331-6	2021	The virtual screening, drug-likeness property, and ADMET studies, and molecular dynamics simulations carried out reveal Newbouldiaquinone A, Foetidin, Chamuvaritin, Cajaflavanone, and Azadirolic acid as potential inhibitors of alpha-amylase while Chamuvaritin, Newbouldiaquinone A, Flowerone, Scoparic acid A and Nimonol were potential inhibitors of alpha-glucosidase enzyme.	cajaflavanone	165-178	sucrase-isomaltase	Homo sapiens	350-367
33583331-6	2021	The virtual screening, drug-likeness property, and ADMET studies, and molecular dynamics simulations carried out reveal Newbouldiaquinone A, Foetidin, Chamuvaritin, Cajaflavanone, and Azadirolic acid as potential inhibitors of alpha-amylase while Chamuvaritin, Newbouldiaquinone A, Flowerone, Scoparic acid A and Nimonol were potential inhibitors of alpha-glucosidase enzyme.	Azadirolic acid	184-199	sucrase-isomaltase	Homo sapiens	350-367
33583331-6	2021	The virtual screening, drug-likeness property, and ADMET studies, and molecular dynamics simulations carried out reveal Newbouldiaquinone A, Foetidin, Chamuvaritin, Cajaflavanone, and Azadirolic acid as potential inhibitors of alpha-amylase while Chamuvaritin, Newbouldiaquinone A, Flowerone, Scoparic acid A and Nimonol were potential inhibitors of alpha-glucosidase enzyme.	newbouldiaquinone A	120-139	sucrase-isomaltase	Homo sapiens	350-367
33295353-0	2021	Carbon nitride nanoparticles as ultrasensitive fluorescent probes for the detection of alpha-glucosidase activity and inhibitor screening.	cyanogen	0-14	sucrase-isomaltase	Homo sapiens	87-104
32971162-11	2021	The extracts from 75%v/v and 95%v/v ethanol and GIA1 significantly delayed the glycemic absorption by lowering alpha-glucosidase activity and glucose transportation of SGLT1.	Ethanol	36-43	sucrase-isomaltase	Homo sapiens	111-128
33554773-2	2021	The aim of this work is to identify and investigate the inhibition mechanism of natural flavonoids and phenolics acids against, the alpha-amylase (alphaA) and alpha-glucosidase (alphaG).	Flavonoids	88-98	sucrase-isomaltase	Homo sapiens	159-176
33554773-2	2021	The aim of this work is to identify and investigate the inhibition mechanism of natural flavonoids and phenolics acids against, the alpha-amylase (alphaA) and alpha-glucosidase (alphaG).	phenolic acid	103-118	sucrase-isomaltase	Homo sapiens	159-176
33567783-1	2021	Semi-synthetic triterpenoids, holding an amino substituted seven-membered A-ring (azepano-ring), which could be synthesized from triterpenic oximes through a Beckmann type rearrangement followed by a reduction of lactame fragment, are considered to be novel promising agents exhibiting anti-microbial, alpha-glucosidase, and butyrylcholinesterase inhibitory activities.	Triterpenes	15-28	sucrase-isomaltase	Homo sapiens	302-319
33295353-2	2021	Herein, we establish a novel method based on fluorescent carbon nitride nanoparticles (CNNPs) for the sensitive detection of the activity of alpha-glucosidase (alpha-glu) and the screening of its inhibitors.	cyanogen	57-71	sucrase-isomaltase	Homo sapiens	141-158
33418317-0	2021	Oleanolic acid indole derivatives as novel alpha-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis.	oleanolic acid indole	0-21	sucrase-isomaltase	Homo sapiens	43-60
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	58-72	sucrase-isomaltase	Homo sapiens	84-101
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	58-72	sucrase-isomaltase	Homo sapiens	161-178
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	74-76	sucrase-isomaltase	Homo sapiens	84-101
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	74-76	sucrase-isomaltase	Homo sapiens	161-178
33418317-4	2021	Indole OA derivatives (2a-2o) exhibited superior alpha-glucosidase inhibitory effects as compared to OA methyl ester derivatives (3a-3l) and OA (with IC50 values of 4.02 muM-5.30 muM v.s.	indole	0-6	sucrase-isomaltase	Homo sapiens	49-66
33418317-4	2021	Indole OA derivatives (2a-2o) exhibited superior alpha-glucosidase inhibitory effects as compared to OA methyl ester derivatives (3a-3l) and OA (with IC50 values of 4.02 muM-5.30 muM v.s.	2a-2o	23-28	sucrase-isomaltase	Homo sapiens	49-66
33418317-7	2021	Findings from this study support that OA indole derivatives are promising alpha-glucosidase inhibitors as a potential management of diabetes mellitus.	Oleanolic Acid	38-40	sucrase-isomaltase	Homo sapiens	74-91
33418317-7	2021	Findings from this study support that OA indole derivatives are promising alpha-glucosidase inhibitors as a potential management of diabetes mellitus.	indole	41-47	sucrase-isomaltase	Homo sapiens	74-91
33183632-0	2021	Chemical structure and inhibition on alpha-glucosidase of polysaccharides from corn silk by fractional precipitation.	Polysaccharides	58-73	sucrase-isomaltase	Homo sapiens	37-54
31955660-0	2021	In silico evaluation of phenolic compounds as inhibitors of alpha-amylase and alpha-glucosidase.	phenolic acid	24-32	sucrase-isomaltase	Homo sapiens	78-95
33459059-0	2022	Insight into the alpha-glucosidase-inhibiting mechanism of beta-PGG, a commonly occurring polyphenol in diets.	beta-pgg	59-67	sucrase-isomaltase	Homo sapiens	17-34
33459059-0	2022	Insight into the alpha-glucosidase-inhibiting mechanism of beta-PGG, a commonly occurring polyphenol in diets.	Polyphenols	90-100	sucrase-isomaltase	Homo sapiens	17-34
33459059-4	2022	beta-PGG showed a mix-type inhibition when it was interacting with alpha-glucosidase.	beta-pgg	0-8	sucrase-isomaltase	Homo sapiens	67-84
33347933-0	2021	A new biological prospective for the 2-phenylbenzofurans as inhibitors of alpha-glucosidase and of the islet amyloid polypeptide formation.	2-phenylbenzofurans	37-56	sucrase-isomaltase	Homo sapiens	74-91
33347933-1	2021	In this study, we have investigated a series of hydroxylated 2-phenylbenzofurans compounds for their inhibitory activity against alpha-amylase and alpha-glucosidase activity.	2-phenylbenzofurans	61-80	sucrase-isomaltase	Homo sapiens	147-164
33245474-4	2021	Expression plasmids encoding SARS-CoV-2 spike (S) and human ACE2 glycoproteins (GP) were tested to evaluate N-glycan modifications induced by alpha-glucosidase inhibition.	n-glycan	108-116	sucrase-isomaltase	Homo sapiens	142-159
33458829-7	2021	While the complex retained the alpha-glucosidase and alpha-amylase inhibitory activity of its phenolic acid precursor, complexation increased in vitro and ex vivo antioxidant activity of the phenolic acid by 1.4 to 10.5-folds.	phenolic acid	94-107	sucrase-isomaltase	Homo sapiens	31-48
33458829-7	2021	While the complex retained the alpha-glucosidase and alpha-amylase inhibitory activity of its phenolic acid precursor, complexation increased in vitro and ex vivo antioxidant activity of the phenolic acid by 1.4 to 10.5-folds.	phenolic acid	191-204	sucrase-isomaltase	Homo sapiens	31-48
33183632-7	2021	Isothermal titration calorimetry (ITC) results illustrated that the binding of CSP80 to alpha-glucosidase complex was spontaneous driven by enthalpy and hydrogen bonds played a major role in the binding.	Hydrogen	153-161	sucrase-isomaltase	Homo sapiens	88-105
33509461-10	2021	Some of fruit extracts were able to inhibit alpha-glucosidase and glycation in methylglyoxal and fructose models, whereas none of them was active for lipase and alpha-amylase.	Pyruvaldehyde	79-92	sucrase-isomaltase	Homo sapiens	44-61
33249154-0	2021	Utilization of the common functional groups in bioactive molecules: Exploring dual inhibitory potential and computational analysis of keto esters against alpha-glucosidase and carbonic anhydrase-II enzymes.	keto esters	134-145	sucrase-isomaltase	Homo sapiens	154-171
33249154-4	2021	These keto ester derivatives were screened for their alpha-glucosidase inhibition potential and the in vitro results revealed compound 3c as the highly active inhibitor with an IC50 value of 12.4 +- 0.16 muM compared to acarbose (IC50 = 942 +- 0.74 muM).	keto ester	6-16	sucrase-isomaltase	Homo sapiens	53-70
33451050-6	2021	Finally, PEGCG showed better inhibition towards alpha-amylase and alpha-glucosidase, which was 4.5 and 52 times of EGCG, respectively.	pegcg	9-14	sucrase-isomaltase	Homo sapiens	66-83
33427491-0	2022	Flavonoids as potential agents in the management of type 2 diabetes through the modulation of alpha-amylase and alpha-glucosidase activity: a review.	Flavonoids	0-10	sucrase-isomaltase	Homo sapiens	112-129
33427491-2	2022	alpha-Amylase and alpha-glucosidase inhibitors have been shown to slow the release of glucose from starch and oligosaccharides, resulting in a delay of glucose absorption and a reduction in postprandial blood glucose levels.	Glucose	86-93	sucrase-isomaltase	Homo sapiens	18-35
33427491-2	2022	alpha-Amylase and alpha-glucosidase inhibitors have been shown to slow the release of glucose from starch and oligosaccharides, resulting in a delay of glucose absorption and a reduction in postprandial blood glucose levels.	Starch	99-105	sucrase-isomaltase	Homo sapiens	18-35
33427491-2	2022	alpha-Amylase and alpha-glucosidase inhibitors have been shown to slow the release of glucose from starch and oligosaccharides, resulting in a delay of glucose absorption and a reduction in postprandial blood glucose levels.	Oligosaccharides	110-126	sucrase-isomaltase	Homo sapiens	18-35
33427491-2	2022	alpha-Amylase and alpha-glucosidase inhibitors have been shown to slow the release of glucose from starch and oligosaccharides, resulting in a delay of glucose absorption and a reduction in postprandial blood glucose levels.	Glucose	152-159	sucrase-isomaltase	Homo sapiens	18-35
33427491-3	2022	Since current alpha-glucosidase inhibitors used in the management of T2D, such as acarbose, have been associated to strong gastrointestinal side effects, the search for novel and safer drugs is considered a hot topic of research.	Acarbose	82-90	sucrase-isomaltase	Homo sapiens	14-31
33427491-6	2022	The aim of this review is to provide an overview on the scientific literature concerning the structure-activity relationship of flavonoids in inhibiting alpha-amylase and alpha-glucosidase, including their type of inhibition and experimental procedures applied.	Flavonoids	128-138	sucrase-isomaltase	Homo sapiens	171-188
33429942-9	2021	In terms of the biological properties, the M. koenigii methanol extract was found to display the greatest amount of antioxidant activity (DPPH; IC50 95.54 microg/mL, ABTS value 118.12 mg GAE/g extract, FRAP value 48.15 mg GAE/g extract), and also revealed the highest alpha-glucosidase and antihypertensive inhibitory activities with percent inhibition values of 84.55 and 84.95.	Methanol	55-63	sucrase-isomaltase	Homo sapiens	268-285
33295908-0	2021	The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against alpha-glucosidase by increasing the polyphenol-enzyme binding interactions.	galloyl	4-11	sucrase-isomaltase	Homo sapiens	89-106
33295908-0	2021	The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against alpha-glucosidase by increasing the polyphenol-enzyme binding interactions.	Catechin	55-64	sucrase-isomaltase	Homo sapiens	89-106
33295908-0	2021	The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against alpha-glucosidase by increasing the polyphenol-enzyme binding interactions.	theaflavin	69-80	sucrase-isomaltase	Homo sapiens	89-106
33295908-0	2021	The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against alpha-glucosidase by increasing the polyphenol-enzyme binding interactions.	Polyphenols	125-135	sucrase-isomaltase	Homo sapiens	89-106
33295908-1	2021	The inhibition properties of 10 tea polyphenols against alpha-glucosidase were studied through inhibition assay, inhibition kinetics, fluorescence quenching and molecular docking.	Polyphenols	36-47	sucrase-isomaltase	Homo sapiens	56-73
33295908-3	2021	The GM could enter into the active site of alpha-glucosidase and bind with the catalytic amino acid residues through hydrogen bonding and pi-conjugation, thus playing an important role in the competitive inhibition of catechins and theaflavins.	gm	4-6	sucrase-isomaltase	Homo sapiens	43-60
33295908-3	2021	The GM could enter into the active site of alpha-glucosidase and bind with the catalytic amino acid residues through hydrogen bonding and pi-conjugation, thus playing an important role in the competitive inhibition of catechins and theaflavins.	Hydrogen	117-125	sucrase-isomaltase	Homo sapiens	43-60
33295908-3	2021	The GM could enter into the active site of alpha-glucosidase and bind with the catalytic amino acid residues through hydrogen bonding and pi-conjugation, thus playing an important role in the competitive inhibition of catechins and theaflavins.	Catechin	218-227	sucrase-isomaltase	Homo sapiens	43-60
33295908-3	2021	The GM could enter into the active site of alpha-glucosidase and bind with the catalytic amino acid residues through hydrogen bonding and pi-conjugation, thus playing an important role in the competitive inhibition of catechins and theaflavins.	theaflavin	232-243	sucrase-isomaltase	Homo sapiens	43-60
33295908-4	2021	The positive linear correlations among the constants characterizing the inhibitory activity and binding affinity of tea polyphenols to alpha-glucosidase indicate that enzyme inhibition by polyphenols is caused by the binding interactions between them, and that the combination of the characterization methods for polyphenol-glucosidase binding is reasonable.	Polyphenols	120-131	sucrase-isomaltase	Homo sapiens	135-152
33295908-4	2021	The positive linear correlations among the constants characterizing the inhibitory activity and binding affinity of tea polyphenols to alpha-glucosidase indicate that enzyme inhibition by polyphenols is caused by the binding interactions between them, and that the combination of the characterization methods for polyphenol-glucosidase binding is reasonable.	Polyphenols	188-199	sucrase-isomaltase	Homo sapiens	135-152
33295908-4	2021	The positive linear correlations among the constants characterizing the inhibitory activity and binding affinity of tea polyphenols to alpha-glucosidase indicate that enzyme inhibition by polyphenols is caused by the binding interactions between them, and that the combination of the characterization methods for polyphenol-glucosidase binding is reasonable.	Polyphenols	120-130	sucrase-isomaltase	Homo sapiens	135-152
33295908-5	2021	In addition, the in vivo hypoglycemic effects of galloylated polyphenols suggest that the GM may be considered as a pharmaceutical fragment for the alleviation of type II diabetes symptoms through alpha-glucosidase inhibition.	gm	90-92	sucrase-isomaltase	Homo sapiens	197-214
32955004-11	2021	Interestingly, the therapeutic impact of alkaloids against blood glucose pathogenesis is mediated through a variety of signaling cascades and pathways, via inhibiting or stimulating a diversity of systems such as inhibition of alpha-glucosidase enzyme, blockade of PTP-1B, deactivation of DPP-IV, increasing insulin sensitivity and modulating the oxidative stress.	Alkaloids	41-50	sucrase-isomaltase	Homo sapiens	227-244
33451050-6	2021	Finally, PEGCG showed better inhibition towards alpha-amylase and alpha-glucosidase, which was 4.5 and 52 times of EGCG, respectively.	epigallocatechin gallate	10-14	sucrase-isomaltase	Homo sapiens	66-83
33272713-0	2021	Synthesis of azachalcones, their alpha-amylase, alpha-glucosidase inhibitory activities, kinetics, and molecular docking studies.	azachalcones	13-25	sucrase-isomaltase	Homo sapiens	48-65
33272713-3	2021	In the current study, twenty-seven azachalcone derivatives 3-29 were synthesized and evaluated for their antihyperglycemic activities by inhibiting alpha-amylase and alpha-glucosidase enzymes.	3-(2-PYRIDYL)-ACRYLOPHENONE	35-46	sucrase-isomaltase	Homo sapiens	166-183
33288319-0	2021	Celebrex derivatives: Synthesis, alpha-glucosidase inhibition, crystal structures and molecular docking studies.	Celecoxib	0-8	sucrase-isomaltase	Homo sapiens	33-50
33288319-1	2021	Celebrex (1), commonly used as an anti-inflammatory drug, was functionalized (compounds 2-9) to identify new alpha-glucosidase inhibitors.	Celecoxib	0-8	sucrase-isomaltase	Homo sapiens	109-126
33288319-10	2021	alpha-Glucosidase is a key target for the anti-diabetic drug development, and its inhibitors are known to exert anti hyperglycemic effect and help in lowering of post-prandial blood glucose levels.	Glucose	182-189	sucrase-isomaltase	Homo sapiens	0-17
33316359-0	2021	New lignans and acetophenone derivatives with alpha-glucosidase inhibitory activity from the leaves of Melicope patulinervia.	Lignans	4-11	sucrase-isomaltase	Homo sapiens	46-63
33316359-0	2021	New lignans and acetophenone derivatives with alpha-glucosidase inhibitory activity from the leaves of Melicope patulinervia.	acetophenone	16-28	sucrase-isomaltase	Homo sapiens	46-63
33509461-10	2021	Some of fruit extracts were able to inhibit alpha-glucosidase and glycation in methylglyoxal and fructose models, whereas none of them was active for lipase and alpha-amylase.	Fructose	97-105	sucrase-isomaltase	Homo sapiens	44-61
33115652-0	2021	Inhibitory mechanism of sinensetin on alpha-glucosidase and non-enzymatic glycation: Insights from spectroscopy and molecular docking analyses.	sinensetin	24-34	sucrase-isomaltase	Homo sapiens	38-55
33115652-4	2021	The binding of sinensetin with alpha-glucosidase was a spontaneous process primarily driven by hydrophobic interaction.	sinensetin	15-25	sucrase-isomaltase	Homo sapiens	31-48
33115652-6	2021	The conformation of alpha-glucosidase was altered by sinensetin, which was revealed by circular dichroism (CD), FTIR spectra, synchronous fluorescence and three-dimensional (3D) fluorescence spectroscopy methods.	sinensetin	53-63	sucrase-isomaltase	Homo sapiens	20-37
33115652-7	2021	Molecular docking analysis demonstrated that sinensetin interacted with the amino acid residues of alpha-glucosidase, which might prevent the entrance of substrate, leading to the decrease of catalytic efficiency of alpha-glucosidase.	sinensetin	45-55	sucrase-isomaltase	Homo sapiens	99-116
33115652-7	2021	Molecular docking analysis demonstrated that sinensetin interacted with the amino acid residues of alpha-glucosidase, which might prevent the entrance of substrate, leading to the decrease of catalytic efficiency of alpha-glucosidase.	sinensetin	45-55	sucrase-isomaltase	Homo sapiens	216-233
32851964-3	2021	OBJECTIVE: In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized and evaluated against alpha-glucosidase in vitro and in silico.	Dithiocarbamate	52-67	sucrase-isomaltase	Homo sapiens	124-141
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Formaldehyde	100-108	sucrase-isomaltase	Homo sapiens	0-18
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Formaldehyde	100-108	sucrase-isomaltase	Homo sapiens	20-22
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Paraffin	115-123	sucrase-isomaltase	Homo sapiens	0-18
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Paraffin	115-123	sucrase-isomaltase	Homo sapiens	20-22
32851964-0	2021	Novel coumarin containing dithiocarbamate derivatives as potent alpha-glucosidase inhibitors for management of type 2 diabetes.	coumarin	6-14	sucrase-isomaltase	Homo sapiens	64-81
32851964-0	2021	Novel coumarin containing dithiocarbamate derivatives as potent alpha-glucosidase inhibitors for management of type 2 diabetes.	Dithiocarbamate	26-41	sucrase-isomaltase	Homo sapiens	64-81
32851964-1	2021	BACKGROUND: alpha-Glucosidase is a hydrolyze enzyme that plays a crucial role in degradation of carbohydrates and starch to glucose.	Carbohydrates	96-109	sucrase-isomaltase	Homo sapiens	12-29
32851964-1	2021	BACKGROUND: alpha-Glucosidase is a hydrolyze enzyme that plays a crucial role in degradation of carbohydrates and starch to glucose.	Starch	114-120	sucrase-isomaltase	Homo sapiens	12-29
32851964-1	2021	BACKGROUND: alpha-Glucosidase is a hydrolyze enzyme that plays a crucial role in degradation of carbohydrates and starch to glucose.	Glucose	124-131	sucrase-isomaltase	Homo sapiens	12-29
32851964-2	2021	Hence, alpha-glucosidase is an important target in the carbohydrate mediated diseases such as diabetes mellitus.	Carbohydrates	55-67	sucrase-isomaltase	Homo sapiens	7-24
32326848-0	2021	Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on alpha-amylase, alpha-glucosidase and lipase.	Anthocyanins	36-48	sucrase-isomaltase	Homo sapiens	116-133
32326848-0	2021	Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on alpha-amylase, alpha-glucosidase and lipase.	Proanthocyanidins	53-65	sucrase-isomaltase	Homo sapiens	116-133
32926336-0	2021	PTP1B and alpha-glucosidase inhibitors from Selaginella rolandi-principis and their glucose uptake stimulation.	Glucose	84-91	sucrase-isomaltase	Homo sapiens	10-27
32926336-10	2021	The obtained result might suggest the potential of new coumarin (1) as a new type of natural PTP1B and alpha-glucosidase inhibitor for further research and development of antidiabetic and obese agents.Graphic abstract.	coumarin	55-63	sucrase-isomaltase	Homo sapiens	103-120
32851964-3	2021	OBJECTIVE: In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized and evaluated against alpha-glucosidase in vitro and in silico.	coumarin	32-40	sucrase-isomaltase	Homo sapiens	124-141
32851964-3	2021	OBJECTIVE: In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized and evaluated against alpha-glucosidase in vitro and in silico.	4a-n	80-84	sucrase-isomaltase	Homo sapiens	124-141
32851964-11	2021	CONCLUSION: Our results suggest that the coumarin-dithiocarbamate scaffold can be a promising lead structure for design potent alpha-glucosidase inhibitors for treatment of type 2 diabetes.	coumarin	41-49	sucrase-isomaltase	Homo sapiens	127-144
32851964-11	2021	CONCLUSION: Our results suggest that the coumarin-dithiocarbamate scaffold can be a promising lead structure for design potent alpha-glucosidase inhibitors for treatment of type 2 diabetes.	Dithiocarbamate	50-65	sucrase-isomaltase	Homo sapiens	127-144
33049236-0	2020	Construction of Fe4O3@alpha-glucosidase magnetic nanoparticles for ligand fishing of alpha-glucosidase inhibitors from a natural tonic Epimedii Folium.	fe4o3	16-21	sucrase-isomaltase	Homo sapiens	22-39
33390442-3	2021	After studying iminopyranose, miglitol, which has alpha-glucosidase inhibitory activity, was approved and used in the clinical treatment of diabetes.	miglitol	30-38	sucrase-isomaltase	Homo sapiens	50-67
33390442-5	2021	As a result, it was found that l-iminofuranose having an alkyl group at C1 position show potent alpha-glucosidase inhibitory activity.	l-iminofuranose	31-46	sucrase-isomaltase	Homo sapiens	96-113
33387581-3	2021	In this review, we discussed the antioxidant potential of chalcones and elucidated the mechanisms of pathways and proteins such as carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), aldose reductase, SLGT-2, and Nrf2 that are targeted by antidiabetic chalcones.	Chalcones	58-67	sucrase-isomaltase	Homo sapiens	181-198
33387581-3	2021	In this review, we discussed the antioxidant potential of chalcones and elucidated the mechanisms of pathways and proteins such as carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), aldose reductase, SLGT-2, and Nrf2 that are targeted by antidiabetic chalcones.	Carbohydrates	131-143	sucrase-isomaltase	Homo sapiens	181-198
33292939-2	2020	Addition of blueberry or blackcurrant powder into oat bran paste increased alpha-amylase and alpha-glucosidase inhibitory activities with a decrease in IC50 values.	bran paste	54-64	sucrase-isomaltase	Homo sapiens	93-110
33376861-0	2020	Discovery of Novel Coumarin Analogs against the alpha-Glucosidase Protein Target of Diabetes Mellitus: Pharmacophore-Based QSAR, Docking, and Molecular Dynamics Simulation Studies.	coumarin	19-27	sucrase-isomaltase	Homo sapiens	48-65
33287588-8	2020	3-Oxo-21beta-acetyl-20beta,28-epoxy-18alpha,19betaN-ursane 5 and compound 7 inhibited alpha-glucosidase with IC50 28.0 microM and 4.0 microM being from 6 to 44 times more active than acarbose.	3-oxo-21beta-acetyl-20beta	0-26	sucrase-isomaltase	Homo sapiens	86-103
33287588-8	2020	3-Oxo-21beta-acetyl-20beta,28-epoxy-18alpha,19betaN-ursane 5 and compound 7 inhibited alpha-glucosidase with IC50 28.0 microM and 4.0 microM being from 6 to 44 times more active than acarbose.	28-epoxy-18alpha,19betan-ursane	27-58	sucrase-isomaltase	Homo sapiens	86-103
33287588-8	2020	3-Oxo-21beta-acetyl-20beta,28-epoxy-18alpha,19betaN-ursane 5 and compound 7 inhibited alpha-glucosidase with IC50 28.0 microM and 4.0 microM being from 6 to 44 times more active than acarbose.	Acarbose	183-191	sucrase-isomaltase	Homo sapiens	86-103
32920141-0	2020	Exploring efficacy of Natural-derived Acetylphenol Scaffold Inhibitors for alpha-Glucosidase: synthesis, in vitro and in vivo biochemical studies.	phenylacetic acid	38-50	sucrase-isomaltase	Homo sapiens	75-92
32920141-2	2020	Here, a collection of acetylphenol analogues derived from paeonol and acetophenone were synthesized and evaluated for their alpha-glucosidase inhibitory activity.	phenylacetic acid	22-34	sucrase-isomaltase	Homo sapiens	124-141
32920141-2	2020	Here, a collection of acetylphenol analogues derived from paeonol and acetophenone were synthesized and evaluated for their alpha-glucosidase inhibitory activity.	paeonol	58-65	sucrase-isomaltase	Homo sapiens	124-141
32920141-2	2020	Here, a collection of acetylphenol analogues derived from paeonol and acetophenone were synthesized and evaluated for their alpha-glucosidase inhibitory activity.	acetophenone	70-82	sucrase-isomaltase	Homo sapiens	124-141
32920141-6	2020	Hydrophobic interactions were the main forces for the formation and stabilization of the enzyme - acetylphenol scaffold inhibitor complex, and induced the topography image changes and aggregation of alpha-glucosidase.	phenylacetic acid	98-110	sucrase-isomaltase	Homo sapiens	199-216
32156165-1	2020	A new series of thiobarbituric (thiopyrimidine trione) enamine derivatives and its analogues barbituric acid derivatives was synthesised, characterised, and screen for in vitro evaluation of alpha-glucosidase enzyme inhibition and anti-glycation activity.	thiobarbituric (thiopyrimidine trione) enamine	16-62	sucrase-isomaltase	Homo sapiens	191-208
32156165-1	2020	A new series of thiobarbituric (thiopyrimidine trione) enamine derivatives and its analogues barbituric acid derivatives was synthesised, characterised, and screen for in vitro evaluation of alpha-glucosidase enzyme inhibition and anti-glycation activity.	barbituric acid	93-108	sucrase-isomaltase	Homo sapiens	191-208
33126072-0	2020	Online coupling Fe3O4@ZIF-67@alpha-glucosidase biomicroreactor with high performance liquid chromatography for rapid screening of alpha-glucosidase inhibitors in tea and their inhibitory activity research.	ferryl iron	16-21	sucrase-isomaltase	Homo sapiens	29-46
33003963-0	2020	Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl-deoxynojirimycin derivatives as potential alpha-glucosidase inhibitors.	n-alkyl-deoxynojirimycin	86-110	sucrase-isomaltase	Homo sapiens	136-153
33003963-1	2020	A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ~ 44 were synthesised and evaluated for their in vitro alpha-glucosidase inhibitory activity to develop alpha-glucosidase inhibitors with high activity.	n-alkyl-1-deoxynojirimycin	18-44	sucrase-isomaltase	Homo sapiens	115-132
33003963-1	2020	A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ~ 44 were synthesised and evaluated for their in vitro alpha-glucosidase inhibitory activity to develop alpha-glucosidase inhibitors with high activity.	n-alkyl-1-deoxynojirimycin	18-44	sucrase-isomaltase	Homo sapiens	164-181
33003963-2	2020	All twenty compounds exhibited alpha-glucosidase inhibitory activity with IC50 values ranging from 30.0 +- 0.6 microM to 2000 microM as compared to standard acarbose (IC50 = 822.0 +- 1.5 microM).	Acarbose	157-165	sucrase-isomaltase	Homo sapiens	31-48
33003963-5	2020	Molecular docking demonstrated that the high active inhibitors interacted with alpha-glucosidase by four types of interactions, including hydrogen bonds, pi-pi stacking interactions, hydrophobic interactions, and electrostatic interaction.	Hydrogen	138-146	sucrase-isomaltase	Homo sapiens	79-96
33126072-0	2020	Online coupling Fe3O4@ZIF-67@alpha-glucosidase biomicroreactor with high performance liquid chromatography for rapid screening of alpha-glucosidase inhibitors in tea and their inhibitory activity research.	ferryl iron	16-21	sucrase-isomaltase	Homo sapiens	130-147
33126072-1	2020	In this work, alpha-glucosidase was immobilized on a type of nanoscaledmagnetic materials Fe3O4@ZIF-67 to construct a biomicroreactor for rapid screening alpha-glucosidase inhibitors.	ferryl iron	90-95	sucrase-isomaltase	Homo sapiens	14-31
33126072-1	2020	In this work, alpha-glucosidase was immobilized on a type of nanoscaledmagnetic materials Fe3O4@ZIF-67 to construct a biomicroreactor for rapid screening alpha-glucosidase inhibitors.	ferryl iron	90-95	sucrase-isomaltase	Homo sapiens	154-171
33241461-0	2020	A colorimetric sensing strategy based on enzyme@metal-organic framework and oxidase-like IrO2/MnO2 nanocomposite for alpha-glucosidase inhibitor screening.	Metals	48-53	sucrase-isomaltase	Homo sapiens	117-134
33241461-0	2020	A colorimetric sensing strategy based on enzyme@metal-organic framework and oxidase-like IrO2/MnO2 nanocomposite for alpha-glucosidase inhibitor screening.	manganese dioxide	94-98	sucrase-isomaltase	Homo sapiens	117-134
33190551-1	2022	Echeveria subrigida is native to Mexico and its methanol extract (ME) shows relevant biological activities for human health, including the alpha-glucosidase inhibitory (alphaGI) activity that suggests its antidiabetic potential.	Methanol	48-56	sucrase-isomaltase	Homo sapiens	139-156
33213224-4	2022	Parmosidone K was evaluated for alpha-glucosidase inhibition and revealed the powerful activity with IC50 value of 3.12 microM.	parmosidone k	0-13	sucrase-isomaltase	Homo sapiens	32-49
32971414-0	2020	Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis.	diarylpentadienone	15-33	sucrase-isomaltase	Homo sapiens	47-64
32941900-0	2020	Characterization, antioxidant activities, and inhibition on alpha-glucosidase activity of corn silk polysaccharides obtained by different extraction methods.	silk polysaccharides	95-115	sucrase-isomaltase	Homo sapiens	60-77
32941900-3	2020	Among the four polysaccharides, CSPu showed the highest inhibitory alpha-glucosidase activity, which might be related to its smaller molecular weight.	Polysaccharides	15-30	sucrase-isomaltase	Homo sapiens	67-84
32941900-3	2020	Among the four polysaccharides, CSPu showed the highest inhibitory alpha-glucosidase activity, which might be related to its smaller molecular weight.	cspu	32-36	sucrase-isomaltase	Homo sapiens	67-84
33312519-1	2020	The strategy of reducing carbohydrate digestibility by controlling the activity of two hydrolyzing enzymes (alpha-amylase and alpha-glucosidase) to control postprandial hyperglycemia is considered as a viable prophylactic treatment of type 2 diabetes mellitus (T2DM).	Carbohydrates	25-37	sucrase-isomaltase	Homo sapiens	126-143
33312519-5	2020	Cereal-derived phenolic compounds, peptides, nonstarch polysaccharides, and lipids have been shown to inhibit alpha-amylase and alpha-glucosidase activities.	Polysaccharides	55-70	sucrase-isomaltase	Homo sapiens	128-145
32971414-3	2020	The sulfonamide-containing series (compounds 10-18) selectively inhibited alpha-glucosidase over DPP-4, in which compound 18 demonstrated the highest activity with an IC50 value of 5.69 +- 0.5 microM through a competitive inhibition mechanism.	Sulfonamides	4-15	sucrase-isomaltase	Homo sapiens	74-91
33065441-0	2020	Indole acrylonitriles as potential anti-hyperglycemic agents: Synthesis, alpha-glucosidase inhibitory activity and molecular docking studies.	indole acrylonitriles	0-21	sucrase-isomaltase	Homo sapiens	73-90
33065441-3	2020	The current study deals with the synthesis of indole acrylonitriles (3-23) and the evaluation of these compounds for their potential for alpha-glucosidase inhibition.	indole acrylonitriles	46-67	sucrase-isomaltase	Homo sapiens	137-154
32971414-4	2020	Structure-activity relationship (SAR) studies concluded that the introduction of the trifluoromethylbenzene sulfonamide moiety was essential for the suppression of alpha-glucosidase.	trifluoromethylbenzene sulfonamide	85-119	sucrase-isomaltase	Homo sapiens	164-181
33065441-6	2020	Compounds 4, 8, 10, 11, 14, 18, and 21 displayed superior inhibition of alpha-glucosidase enzyme in the range of (IC50 = 0.53 +- 0.01-1.36 +- 0.04 muM) as compared to the standard acarbose.	Acarbose	180-188	sucrase-isomaltase	Homo sapiens	72-89
32971414-7	2020	The overall results suggest that the new sulfonamide-containing diarylpentadienones, compound 18, could be a promising candidate in the search for a new alpha-glucosidase inhibitor, and can serve as a basis for further studies involving hit-to-lead optimization, in vivo efficacy and safety assessment in an animal model and mechanism of action for the treatment of T2DM patients.	Sulfonamides	41-52	sucrase-isomaltase	Homo sapiens	153-170
32947132-0	2020	Novel enantiopure isoxazolidine and C-alkyl imine oxide derivatives as potential hypoglycemic agents: Design, synthesis, dual inhibitors of alpha-amylase and alpha-glucosidase, ADMET and molecular docking study.	c-alkyl imine oxide	36-55	sucrase-isomaltase	Homo sapiens	158-175
32971414-7	2020	The overall results suggest that the new sulfonamide-containing diarylpentadienones, compound 18, could be a promising candidate in the search for a new alpha-glucosidase inhibitor, and can serve as a basis for further studies involving hit-to-lead optimization, in vivo efficacy and safety assessment in an animal model and mechanism of action for the treatment of T2DM patients.	diarylpentadienones	64-83	sucrase-isomaltase	Homo sapiens	153-170
33075241-4	2020	On the other hand, IC50 values were calculated for DPPH   , and ABTS   + scavenging, acetylcholinesterase, and alpha-glucosidase inhibition effects of narcissoside.	narcissin flavonol	151-163	sucrase-isomaltase	Homo sapiens	111-128
32916220-2	2020	The carbohydrate hydrolysing enzyme, alpha-glucosidase, is generally competitively inhibited by the alpha-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia.	Carbohydrates	4-16	sucrase-isomaltase	Homo sapiens	37-54
32916220-2	2020	The carbohydrate hydrolysing enzyme, alpha-glucosidase, is generally competitively inhibited by the alpha-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia.	Carbohydrates	4-16	sucrase-isomaltase	Homo sapiens	100-117
32916220-2	2020	The carbohydrate hydrolysing enzyme, alpha-glucosidase, is generally competitively inhibited by the alpha-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia.	Glucose	156-163	sucrase-isomaltase	Homo sapiens	37-54
32916220-2	2020	The carbohydrate hydrolysing enzyme, alpha-glucosidase, is generally competitively inhibited by the alpha-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia.	Glucose	156-163	sucrase-isomaltase	Homo sapiens	100-117
30618297-0	2020	Samin-derived flavonolignans, a new series of antidiabetic agents having dual inhibition against alpha-glucosidase and free radicals.	derived	6-13	sucrase-isomaltase	Homo sapiens	97-114
30618297-0	2020	Samin-derived flavonolignans, a new series of antidiabetic agents having dual inhibition against alpha-glucosidase and free radicals.	Flavonolignans	14-28	sucrase-isomaltase	Homo sapiens	97-114
30618297-3	2020	Upon evaluation of antidiabetic activity of the synthesized products, epicatechinosamin (beta-2g) was the most active alpha-glucosidase inhibitor toward maltase and sucrase.	epicatechinosamin	70-87	sucrase-isomaltase	Homo sapiens	118-135
33126534-2	2020	Studies support the hypoglycemic effect of Cynarascolymus (Cs) extracts due to the content of chlorogenic acid, which is a potent inhibitor of glucose 6-phosphate translocase and of dicaffeoylquinic acid derivatives that modulate the activity of alpha-glucosidase.	Chlorogenic Acid	94-110	sucrase-isomaltase	Homo sapiens	246-263
33092516-7	2021	In intestines it blocks alpha-glucosidase contributing to glucose absorption decrease.	Glucose	58-65	sucrase-isomaltase	Homo sapiens	24-41
33075241-5	2020	IC50 values narcissoside, as 11.54 nM for AChE and 65.58 nM for alpha-glucosidase were calculated with % Activity-[Inhibitory] graphs.	narcissin flavonol	12-24	sucrase-isomaltase	Homo sapiens	64-81
32747291-2	2020	In this study, the inhibitory effects of Lentinus edodes mycelia polysaccharide (LMP) on alpha-glucosidase activity, the formation of advanced glycation end products (AGEs) and high glucose-induced human umbilical vein endothelial cells (HUVECs) damage were explored.	mycelia polysaccharide	57-79	sucrase-isomaltase	Homo sapiens	89-106
32747291-2	2020	In this study, the inhibitory effects of Lentinus edodes mycelia polysaccharide (LMP) on alpha-glucosidase activity, the formation of advanced glycation end products (AGEs) and high glucose-induced human umbilical vein endothelial cells (HUVECs) damage were explored.	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	81-84	sucrase-isomaltase	Homo sapiens	89-106
32747291-4	2020	The results revealed that LMP had a reversible inhibition on alpha-glucosidase activity in a mixed-type manner.	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	26-29	sucrase-isomaltase	Homo sapiens	61-78
32747291-6	2020	LMP quenched the fluorescence of alpha-glucosidase through the static quenching and formed the LMP-alpha-glucosidase complex.	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	0-3	sucrase-isomaltase	Homo sapiens	33-50
32747291-6	2020	LMP quenched the fluorescence of alpha-glucosidase through the static quenching and formed the LMP-alpha-glucosidase complex.	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	0-3	sucrase-isomaltase	Homo sapiens	99-116
33047276-0	2021	Synthesis of 4-alkylaminoimidazo[1,2-a]pyridines linked to carbamate moiety as potent alpha-glucosidase inhibitors.	4-alkylaminoimidazo[1,2-a]pyridines	13-48	sucrase-isomaltase	Homo sapiens	86-103
33043693-4	2022	Compound 9 showed remarkable alpha-glucosidase inhibitory activity with an IC50 value of 0.31 muM, and the triterpene glycosides (1-5) exhibited moderate alpha-glucosidase inhibitory activity.	triterpene glycosides	107-128	sucrase-isomaltase	Homo sapiens	154-171
33047276-0	2021	Synthesis of 4-alkylaminoimidazo[1,2-a]pyridines linked to carbamate moiety as potent alpha-glucosidase inhibitors.	Carbamates	59-68	sucrase-isomaltase	Homo sapiens	86-103
33047276-1	2021	In this work, various imidazo[1,2-a]pyridines linked to carbamate moiety were designed, synthesized, and evaluated for their alpha-glucosidase inhibitory activity.	imidazo(1,2-a)pyridine	22-45	sucrase-isomaltase	Homo sapiens	125-142
33047276-1	2021	In this work, various imidazo[1,2-a]pyridines linked to carbamate moiety were designed, synthesized, and evaluated for their alpha-glucosidase inhibitory activity.	Carbamates	56-65	sucrase-isomaltase	Homo sapiens	125-142
32936186-5	2020	Further evaluation for alpha-glucosidase inhibition revealed that compounds 15ca and 15da were more active than acarbose, the reference inhibitor.	15ca	76-80	sucrase-isomaltase	Homo sapiens	23-40
33006707-0	2021	Diabetes medications as potential calorie restriction mimetics-a focus on the alpha-glucosidase inhibitor acarbose.	Acarbose	106-114	sucrase-isomaltase	Homo sapiens	78-95
33006707-4	2021	Alpha-glucosidase inhibitors (AGIs) are compounds that function predominantly within the gastrointestinal tract to inhibit alpha-glucosidase and alpha-amylase enzymatic digestion of complex carbohydrates, delaying and decreasing monosaccharide uptake from the gut in the treatment of T2D.	Carbohydrates	190-203	sucrase-isomaltase	Homo sapiens	0-17
33006707-4	2021	Alpha-glucosidase inhibitors (AGIs) are compounds that function predominantly within the gastrointestinal tract to inhibit alpha-glucosidase and alpha-amylase enzymatic digestion of complex carbohydrates, delaying and decreasing monosaccharide uptake from the gut in the treatment of T2D.	Monosaccharides	229-243	sucrase-isomaltase	Homo sapiens	0-17
33039052-0	2020	Novel carbohydrate-triazole derivatives as potential alpha-glucosidase inhibitors.	Carbohydrates	6-18	sucrase-isomaltase	Homo sapiens	53-70
33039052-0	2020	Novel carbohydrate-triazole derivatives as potential alpha-glucosidase inhibitors.	Triazoles	19-27	sucrase-isomaltase	Homo sapiens	53-70
33039052-1	2020	A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their alpha-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.	pyrano[2, 3-d]trizaole	18-40	sucrase-isomaltase	Homo sapiens	78-95
33039052-3	2020	The molecular docking revealed that compound 10f could bind to alpha-glucosidase via the hydrophobic, pi-pi stacking, and hydrogen bonding interactions.	Hydrogen	122-130	sucrase-isomaltase	Homo sapiens	63-80
32936186-5	2020	Further evaluation for alpha-glucosidase inhibition revealed that compounds 15ca and 15da were more active than acarbose, the reference inhibitor.	15da	85-89	sucrase-isomaltase	Homo sapiens	23-40
32936186-5	2020	Further evaluation for alpha-glucosidase inhibition revealed that compounds 15ca and 15da were more active than acarbose, the reference inhibitor.	Acarbose	112-120	sucrase-isomaltase	Homo sapiens	23-40
32567729-4	2020	Compounds 4a-r exhibited a good-to-moderate alpha-amylase and alpha-glucosidase inhibitory activity, with IC50 values ranging from 0.0410 to 0.0916 micromol/ml and 0.0146 to 0.0732 micromol/ml, respectively.	4a-r	10-14	sucrase-isomaltase	Homo sapiens	62-79
33024458-7	2020	Furthermore, Kenyan coffee beans inhibited alpha-glucosidase activity, which may partially explain why Kenyan coffee reduces postprandial interstitial glucose levels.	Glucose	151-158	sucrase-isomaltase	Homo sapiens	43-60
32717184-0	2020	alpha-Glucosidase immobilization on polydopamine-coated cellulose filter paper and enzyme inhibitor screening.	polydopamine	36-48	sucrase-isomaltase	Homo sapiens	0-17
32717184-3	2020	In virtue of the self-polymerization-adhesion behavior of dopamine, CFP was coated with a polydopamine composite layer and then alpha-glucosidase is covalently bound to the modified CFP through Schiff base reaction and Michael addition reaction.	Dopamine	58-66	sucrase-isomaltase	Homo sapiens	128-145
32717184-3	2020	In virtue of the self-polymerization-adhesion behavior of dopamine, CFP was coated with a polydopamine composite layer and then alpha-glucosidase is covalently bound to the modified CFP through Schiff base reaction and Michael addition reaction.	Schiff Bases	194-205	sucrase-isomaltase	Homo sapiens	128-145
33083375-0	2020	Investigation of Anthocyanidins and Anthocyanins for Targeting alpha-Glucosidase in Diabetes Mellitus.	Anthocyanins	17-31	sucrase-isomaltase	Homo sapiens	63-80
33083375-0	2020	Investigation of Anthocyanidins and Anthocyanins for Targeting alpha-Glucosidase in Diabetes Mellitus.	Anthocyanins	36-48	sucrase-isomaltase	Homo sapiens	63-80
33083375-3	2020	However, limited information is available regarding the inhibitory effect and interactions of anthocyanidins on alpha-glucosidase, the key enzyme that controls diabetes through degrading carbohydrate.	Anthocyanins	94-108	sucrase-isomaltase	Homo sapiens	112-129
33083375-3	2020	However, limited information is available regarding the inhibitory effect and interactions of anthocyanidins on alpha-glucosidase, the key enzyme that controls diabetes through degrading carbohydrate.	Carbohydrates	187-199	sucrase-isomaltase	Homo sapiens	112-129
33083375-5	2020	The results suggested that anthocyanidins exhibit half maximal inhibitory concentration of 4~55 muM; the strongest and weakest alpha-glucosidase inhibitors were delphinidin and malvidin, respectively.	Anthocyanins	27-41	sucrase-isomaltase	Homo sapiens	127-144
33083375-6	2020	Indeed, delphinidin inhibits alpha-glucosidase in a mixed type, close to non-competitive manner with an inhibitory constant of 78 nM.	delphinidin	8-19	sucrase-isomaltase	Homo sapiens	29-46
33083382-0	2020	In Vitro Inhibitory Effects of Organic Acids Identified in Commercial Vinegars on alpha-Amylase and alpha-Glucosidase.	organic acids	31-44	sucrase-isomaltase	Homo sapiens	100-117
33083382-1	2020	The aim of this work was to evaluate the inhibitory activities of organic acids identified from commercial vinegars on alpha-amylase and alpha-glucosidase.	organic acids	66-79	sucrase-isomaltase	Homo sapiens	137-154
33083382-4	2020	Citric acid had the lowest IC50 values for alpha-amylase and alpha-glucosidase activities 0.64+-0.04 muM/mL and 8.95+-0.05 muM/mL, respectively, and thus exhibited the strongest antidiabetic effect.	Citric Acid	0-11	sucrase-isomaltase	Homo sapiens	61-78
33133574-0	2020	Antioxidant and alpha-glucosidase inhibitory capacity of nonextractable polyphenols in Mopan persimmon.	Polyphenols	72-83	sucrase-isomaltase	Homo sapiens	16-33
33133574-0	2020	Antioxidant and alpha-glucosidase inhibitory capacity of nonextractable polyphenols in Mopan persimmon.	mopan persimmon	87-102	sucrase-isomaltase	Homo sapiens	16-33
33133574-1	2020	This study was to evaluate and compare the polyphenols contents, antioxidant capacities, and alpha-glucosidase inhibitory abilities of extractable and nonextractable polyphenols (EP and NEP) in Mopan persimmon.	Polyphenols	166-177	sucrase-isomaltase	Homo sapiens	93-110
32982217-0	2020	Erratum: Fabrication and Characterization of Glimepiride Nanosuspension by Ultrasonication-Assisted Precipitation for Improvement of Oral Bioavailability and in vitro alpha-Glucosidase Inhibition [Corrigendum].	glimepiride	45-56	sucrase-isomaltase	Homo sapiens	167-184
32688112-0	2020	Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of alpha-glucosidase inhibition, docking, and kinetic studies.	pyridazine n-aryl acetamides	30-58	sucrase-isomaltase	Homo sapiens	83-100
32688112-2	2020	By this approach, a new series of pyridazine-based compounds were synthesized, characterized and evaluated for their activities against alpha-glucosidase enzyme.	pyridazine	34-44	sucrase-isomaltase	Homo sapiens	136-153
32738998-0	2020	Synthesis, alpha-glucosidase inhibition, and molecular docking studies of novel N-substituted hydrazide derivatives of atranorin as antidiabetic agents.	atranorin	119-128	sucrase-isomaltase	Homo sapiens	11-28
32717690-0	2020	Probing 2-acetylbenzofuran hydrazones and their metal complexes as alpha-glucosidase inhibitors.	2-acetylbenzofuran hydrazones	8-37	sucrase-isomaltase	Homo sapiens	67-84
32688112-3	2020	In-vitro alpha-glucosidase assay established that twelve compounds are more potent than acarbose.	Acarbose	88-96	sucrase-isomaltase	Homo sapiens	9-26
32717690-0	2020	Probing 2-acetylbenzofuran hydrazones and their metal complexes as alpha-glucosidase inhibitors.	Metals	48-53	sucrase-isomaltase	Homo sapiens	67-84
32717690-1	2020	Inhibition of alpha-glucosidase is one of the important approaches in designing antidiabetic drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase in blood sugar levels in diabetic patients.	Carbohydrates	131-144	sucrase-isomaltase	Homo sapiens	14-31
32870131-4	2022	The present study elaborates on the isolation, structural and functional characterization of Arbortristoside-C and its inhibition properties against alpha-glucosidase, an important target for diabetes mellitus.	arbortristoside C	93-110	sucrase-isomaltase	Homo sapiens	149-166
32717690-1	2020	Inhibition of alpha-glucosidase is one of the important approaches in designing antidiabetic drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase in blood sugar levels in diabetic patients.	Blood Glucose	190-201	sucrase-isomaltase	Homo sapiens	14-31
32717690-2	2020	In the present study we designed a novel series of 2-acetylbenzofuran hydrazones (L1-L7) and their metal (II) complexes Cu (II), Co (II), Zn (II) and Mn (II) (8-29) and screened for inhibitory activity against the yeast alpha-glucosidase.	2-acetylbenzofuran hydrazones	51-80	sucrase-isomaltase	Homo sapiens	220-237
32717690-2	2020	In the present study we designed a novel series of 2-acetylbenzofuran hydrazones (L1-L7) and their metal (II) complexes Cu (II), Co (II), Zn (II) and Mn (II) (8-29) and screened for inhibitory activity against the yeast alpha-glucosidase.	metal (ii)	99-109	sucrase-isomaltase	Homo sapiens	220-237
32870131-10	2022	The purified Arbortristoside-C showed inhibition against mammalian alpha-glucosidase, suggesting its potential to treat Diabetes mellitus.	arbortristoside C	13-30	sucrase-isomaltase	Homo sapiens	67-84
32851965-0	2021	Indane-1,3-diones: as potential and selective alpha-glucosidase inhibitors, their synthesis, in vitro and in silico studies.	indane-1,3-diones	0-17	sucrase-isomaltase	Homo sapiens	46-63
32627220-2	2020	In this work, we show that phenolic extracts from Spirulina (p-Coumaric acid) possessed inhibitory potential on alpha-glucosidase (IC50  = 1.67 +- 0.02 mM) and tyrosinase (IC50  = 52.71 +- 3.01 mM).	p-coumaric acid	61-76	sucrase-isomaltase	Homo sapiens	112-129
32627220-3	2020	Moreover, p-Coumaric acid inhibited alpha-glucosidase and tyrosinase in a reversible mixed-type manner.	p-coumaric acid	10-25	sucrase-isomaltase	Homo sapiens	36-53
32627220-4	2020	Interestingly, molecular docking demonstrated that p-Coumaric acid penetrated in depth of the active-site of tyrosinase and alpha-glucosidase by the noncovalent force or interaction.	p-coumaric acid	51-66	sucrase-isomaltase	Homo sapiens	124-141
32627220-8	2020	Herein, the present study is the first to present high levels of p-Coumaric acid from Spirulina, which simultaneously possessed inhibition potential on alpha-glucosidase and tyrosinase.	p-coumaric acid	65-80	sucrase-isomaltase	Homo sapiens	152-169
32627855-2	2020	In this study, the effects of three common caffeoylquinic acids (CQAs) (chlorogenic acid, isochlorogenic acid A, and cynarin) on alpha-glucosidase activity and glucose consumption in HepG2 cells were systematically compared.	caffeoylquinic acid	43-63	sucrase-isomaltase	Homo sapiens	129-146
32627855-2	2020	In this study, the effects of three common caffeoylquinic acids (CQAs) (chlorogenic acid, isochlorogenic acid A, and cynarin) on alpha-glucosidase activity and glucose consumption in HepG2 cells were systematically compared.	caffeoylquinic acid	65-69	sucrase-isomaltase	Homo sapiens	129-146
32627855-2	2020	In this study, the effects of three common caffeoylquinic acids (CQAs) (chlorogenic acid, isochlorogenic acid A, and cynarin) on alpha-glucosidase activity and glucose consumption in HepG2 cells were systematically compared.	Chlorogenic Acid	72-88	sucrase-isomaltase	Homo sapiens	129-146
32627855-2	2020	In this study, the effects of three common caffeoylquinic acids (CQAs) (chlorogenic acid, isochlorogenic acid A, and cynarin) on alpha-glucosidase activity and glucose consumption in HepG2 cells were systematically compared.	Isochlorogenic acid A	90-111	sucrase-isomaltase	Homo sapiens	129-146
32627855-2	2020	In this study, the effects of three common caffeoylquinic acids (CQAs) (chlorogenic acid, isochlorogenic acid A, and cynarin) on alpha-glucosidase activity and glucose consumption in HepG2 cells were systematically compared.	cynarine	117-124	sucrase-isomaltase	Homo sapiens	129-146
32627855-3	2020	Their alpha-glucosidase inhibitory activities followed the order of isochlorogenic acid A > chlorogenic acid > cynarin.	Isochlorogenic acid A	68-89	sucrase-isomaltase	Homo sapiens	6-23
32627855-3	2020	Their alpha-glucosidase inhibitory activities followed the order of isochlorogenic acid A > chlorogenic acid > cynarin.	Chlorogenic Acid	71-87	sucrase-isomaltase	Homo sapiens	6-23
32627855-3	2020	Their alpha-glucosidase inhibitory activities followed the order of isochlorogenic acid A > chlorogenic acid > cynarin.	cynarine	111-118	sucrase-isomaltase	Homo sapiens	6-23
32627855-6	2020	The effect of caffeoyl group distribution on the alpha-glucosidase inhibitory activity was clarified by the molecular docking results.	caffeoyl	14-22	sucrase-isomaltase	Homo sapiens	49-66
32627855-10	2020	Isochlorogenic acid A exhibited the strongest alpha-glucosidase inhibitory activity and highest glucose consumption in HepG2 cells with low cytotoxicity.	Isochlorogenic acid A	0-21	sucrase-isomaltase	Homo sapiens	46-63
33164378-0	2020	[Study on binding kinetics profiles of tea polyphenols-alpha-glucosidase interaction].	Polyphenols	43-54	sucrase-isomaltase	Homo sapiens	55-72
33164378-2	2020	Herein, using ECG as research object, the surface plasmon resonance(SPR) analysis were employed to study the binding affinities and kinetic parameters of three tea polyphenols components on alpha-glucosidase, respectively.	Polyphenols	164-175	sucrase-isomaltase	Homo sapiens	190-207
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Water	77-82	sucrase-isomaltase	Homo sapiens	112-129
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Water	77-82	sucrase-isomaltase	Homo sapiens	248-265
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Polyphenols	229-240	sucrase-isomaltase	Homo sapiens	112-129
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Polyphenols	229-240	sucrase-isomaltase	Homo sapiens	248-265
32838552-9	2021	Studies were consistent overall in showing stronger inhibition of alpha-amylase compared to alpha-glucosidase by proanthocyanidin- and/or ellagitannin-rich fruit extracts.	proanthocyanidin	113-129	sucrase-isomaltase	Homo sapiens	92-109
32913908-2	2020	Antidiabetic activities of the synthesized hydroxytriazenes were investigated by alpha-glucosidase and alpha-amylase inhibition method and IC50 values were recorded.	hydroxytriazenes	43-59	sucrase-isomaltase	Homo sapiens	81-98
32672281-0	2020	A ratiometric fluorescent biosensor for the sensitive determination of alpha-glucosidase activity and acarbose based on N-doped carbon dots.	Carbon	128-134	sucrase-isomaltase	Homo sapiens	71-88
32799570-2	2020	Kolaviron significantly inhibited alpha-glucosidase and alpha-amylase activities, and intestinal glucose absorption dose-dependently, while promoting muscle glucose uptake.	kolaviron	0-9	sucrase-isomaltase	Homo sapiens	34-51
32672281-1	2020	In this work, a novel ratiometric fluorescent platform for alpha-glucosidase (alpha-glu) and its inhibitor was constructed based on N-doped carbon dots (N-CDs).	n-doped carbon dots	132-151	sucrase-isomaltase	Homo sapiens	59-76
32672281-1	2020	In this work, a novel ratiometric fluorescent platform for alpha-glucosidase (alpha-glu) and its inhibitor was constructed based on N-doped carbon dots (N-CDs).	n-cds	153-158	sucrase-isomaltase	Homo sapiens	59-76
32672281-2	2020	The alpha-glucosidase present can catalyze the release of hydroquinone (HQ) from alpha-arbutin.	hydroquinone	58-70	sucrase-isomaltase	Homo sapiens	4-21
32672281-2	2020	The alpha-glucosidase present can catalyze the release of hydroquinone (HQ) from alpha-arbutin.	alpha-Arbutin	81-94	sucrase-isomaltase	Homo sapiens	4-21
32672281-5	2020	However, in the presence of acarbose, the activity of alpha-glucosidase is inhibited, and alpha-arbutin cannot be hydrolyzed to hydroquinone, leading to the fluorescence recovery of N-CDs at 425 nm and the fluorescence decrease of PHQ-PEI at 510 nm.	Acarbose	28-36	sucrase-isomaltase	Homo sapiens	54-71
32672281-5	2020	However, in the presence of acarbose, the activity of alpha-glucosidase is inhibited, and alpha-arbutin cannot be hydrolyzed to hydroquinone, leading to the fluorescence recovery of N-CDs at 425 nm and the fluorescence decrease of PHQ-PEI at 510 nm.	n-cds	182-187	sucrase-isomaltase	Homo sapiens	54-71
32815422-0	2022	Five new phloroglucinol derivatives from Syzygium brachyantherum and their alpha-glucosidase and PTP1B inhibitory activities.	Phloroglucinol	9-23	sucrase-isomaltase	Homo sapiens	75-92
32789301-2	2020	The results of in vitro antidiabetic study against alpha-glucosidase indicated that compound 5o bearing 2-CH3-5-NO2 substituent on phenyl ring was found to be the most active compound against both enzymes.	2-ch3-5-no2	104-115	sucrase-isomaltase	Homo sapiens	51-68
32803321-0	2020	"Turn-on" fluorometric probe for alpha-glucosidase activity using red fluorescent carbon dots and 3,3",5,5"-tetramethylbenzidine.	Carbon	82-88	sucrase-isomaltase	Homo sapiens	33-50
32803321-0	2020	"Turn-on" fluorometric probe for alpha-glucosidase activity using red fluorescent carbon dots and 3,3",5,5"-tetramethylbenzidine.	3,3',5,5'-tetramethylbenzidine	98-128	sucrase-isomaltase	Homo sapiens	33-50
32803321-1	2020	A turn-on method for determining alpha-glucosidase activity is described using a chemical redox strategy in which the fluorescence of red fluorescent carbon dots (CDs) is modulated.	Methane	150-161	sucrase-isomaltase	Homo sapiens	33-50
32803321-1	2020	A turn-on method for determining alpha-glucosidase activity is described using a chemical redox strategy in which the fluorescence of red fluorescent carbon dots (CDs) is modulated.	cds	163-166	sucrase-isomaltase	Homo sapiens	33-50
32803321-6	2020	However, hydrolysis of L-ascorbic acid-2-O-alpha-D-glucopyranosyl by the enzyme alpha-glucosidase causes formation of ascorbic acid .	ascorbic acid 2-O-glucoside	23-65	sucrase-isomaltase	Homo sapiens	80-97
32803321-6	2020	However, hydrolysis of L-ascorbic acid-2-O-alpha-D-glucopyranosyl by the enzyme alpha-glucosidase causes formation of ascorbic acid .	Ascorbic Acid	25-38	sucrase-isomaltase	Homo sapiens	80-97
32803321-11	2020	Graphical Abstract Schematic of the method used to prepare the carbon dots and the mechanisms involved in determining alpha-glucosidase activity.	Carbon	63-69	sucrase-isomaltase	Homo sapiens	118-135
32544738-0	2020	Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of alpha-amylase and alpha-glucosidase.	(e)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine	27-86	sucrase-isomaltase	Homo sapiens	141-158
32544738-1	2020	(E)-3-(2-Benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazines analogs 1-27 were synthesized by multi-step reaction scheme and subjected to in vitro inhibitory screening against alpha-amylase and alpha-glucosidase enzymes.	(e)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazines	0-60	sucrase-isomaltase	Homo sapiens	194-211
32563964-0	2020	Synthesis, alpha-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives.	4-(5-fluoro-2-substituted-1h-benzimidazol-6-yl)morpholine	70-127	sucrase-isomaltase	Homo sapiens	11-28
32563964-1	2020	In this study, a new series of 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives has been synthesized and screened for their alpha-glucosidase inhibitory potential.	4-(5-fluoro-2-substituted-1h-benzimidazol-6-yl)morpholine	31-88	sucrase-isomaltase	Homo sapiens	145-162
32722404-6	2020	Additionally, the synthesized AgNPs showed noticeable inhibition of carbohydrate hydrolyzing enzymes mainly, alpha-amylase (IC50, 60.2 +- 2.15 mug/mL) and alpha-glucosidase (IC50, 62.5 +- 2.75 mug/mL).	agnps	30-35	sucrase-isomaltase	Homo sapiens	155-172
32563890-0	2020	Synthesis of new curcumin derivatives as influential antidiabetic alpha-glucosidase and alpha-amylase inhibitors with anti-oxidant activity.	Curcumin	17-25	sucrase-isomaltase	Homo sapiens	66-83
32802126-4	2020	This study aims to determine if date seed polyphenols inhibit the activity of the enzymes (alpha-amylase and alpha-glucosidase), responsible for the digestion of carbohydrates and modulating the glucose uptake by human liver cells.	Polyphenols	42-53	sucrase-isomaltase	Homo sapiens	109-126
32802126-4	2020	This study aims to determine if date seed polyphenols inhibit the activity of the enzymes (alpha-amylase and alpha-glucosidase), responsible for the digestion of carbohydrates and modulating the glucose uptake by human liver cells.	Carbohydrates	162-175	sucrase-isomaltase	Homo sapiens	109-126
32802126-4	2020	This study aims to determine if date seed polyphenols inhibit the activity of the enzymes (alpha-amylase and alpha-glucosidase), responsible for the digestion of carbohydrates and modulating the glucose uptake by human liver cells.	Glucose	195-202	sucrase-isomaltase	Homo sapiens	109-126
31448679-0	2020	Inhibitory effect of alpha-ketoglutaric acid on alpha-glucosidase: integrating molecular dynamics simulation and inhibition kinetics.	Ketoglutaric Acids	21-44	sucrase-isomaltase	Homo sapiens	48-65
31448679-1	2020	The inhibition of alpha-glucosidase is used as a key clinical approach to treat type 2 diabetes mellitus and thus, we assessed the inhibitory effect of alpha-ketoglutaric acid (AKG) on alpha-glucosidase with both an enzyme kinetic assay and computational simulations.	Ketoglutaric Acids	152-175	sucrase-isomaltase	Homo sapiens	18-35
31448679-1	2020	The inhibition of alpha-glucosidase is used as a key clinical approach to treat type 2 diabetes mellitus and thus, we assessed the inhibitory effect of alpha-ketoglutaric acid (AKG) on alpha-glucosidase with both an enzyme kinetic assay and computational simulations.	Ketoglutaric Acids	152-175	sucrase-isomaltase	Homo sapiens	185-202
32645216-8	2020	Additionally, the lyophilized water extract inhibited the in vitro activity of alpha-amylase, alpha-glucosidase, and angiotensin converting enzyme and showed cytotoxic effects towards Caco-2, A549, and HepG2 cancer cells, but no cytotoxicity towards IMR90 cells.	Water	30-35	sucrase-isomaltase	Homo sapiens	94-111
32707893-7	2020	A high linear correlation (R = 0.723, p <= 0.05) was observed between flavan-3-ol contents and the alpha-glucosidase inhibitory activity.	flavan-3-ol	70-81	sucrase-isomaltase	Homo sapiens	99-116
32070843-0	2020	Inhibition mechanism of ferulic acid against alpha-amylase and alpha-glucosidase.	ferulic acid	24-36	sucrase-isomaltase	Homo sapiens	63-80
32527562-0	2020	Synthesis of tetracyclic oxindoles and evaluation of their alpha-glucosidase inhibitory and glucose consumption-promoting activity.	tetracyclic oxindoles	13-34	sucrase-isomaltase	Homo sapiens	59-76
32685927-0	2020	Structural elucidation, molecular docking, alpha-amylase and alpha-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives.	5-aminonicotinic acid	101-123	sucrase-isomaltase	Homo sapiens	61-78
32685927-1	2020	In this study, 5-amino-nicotinic acid derivatives (1-13) have been designed and synthesized to evaluate their inhibitory potential against alpha-amylase and alpha-glucosidase enzymes.	5-aminonicotinic acid	15-37	sucrase-isomaltase	Homo sapiens	157-174
32450390-0	2020	Benzofuran-selenadiazole hybrids as novel alpha-glucosidase and cyclooxygenase-2 inhibitors with antioxidant and cytotoxic properties.	benzofuran-selenadiazole	0-24	sucrase-isomaltase	Homo sapiens	42-59
32450390-1	2020	Series of 2-arylbenzofuran-1,2,3-selenodiazole hybrids were prepared via multiple reactions and then evaluated in vitro through enzymatic assay for inhibitory effect against alpha-glucosidase and cyclooxygenase-2 (COX-2) activities including antioxidant activity.	2-arylbenzofuran-1,2,3-selenodiazole	10-46	sucrase-isomaltase	Homo sapiens	174-191
32450390-2	2020	The presence of 1,2,3-selenodiazole moiety resulted in increased inhibitory effect for compounds 4a-f against alpha-glucosidase and COX-2 activities, and increased free radical scavenging activity.	1,2,3-selenodiazole	16-35	sucrase-isomaltase	Homo sapiens	110-127
32527562-3	2020	Compound 4l competitively and reversibly inhibited alpha-glucosidase (IC50 = 3.64 muM) with activity 14-fold higher than that of acarbose.	Acarbose	129-137	sucrase-isomaltase	Homo sapiens	51-68
32668697-9	2020	The best results were found in the alpha-glucosidase assay, as M. incana hydroalcoholic extract was able to inhibit the enzyme alpha-glucosidase up to 100% without significant differences, compared to the antidiabetic drug acarbose.	Acarbose	223-231	sucrase-isomaltase	Homo sapiens	35-52
32413625-0	2020	Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel alpha-glucosidase inhibitors.	2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles	47-105	sucrase-isomaltase	Homo sapiens	115-132
32413625-3	2020	The current study reports a series of pyridine based synthetic analogues for their alpha-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies.	pyridine	38-46	sucrase-isomaltase	Homo sapiens	83-100
32070843-1	2020	The inhibitory mechanisms of ferulic acid against alpha-amylase and alpha-glucosidase were investigated by enzyme kinetic analysis, circular dichroism (CD), Fourier-transform infrared (FT-IR) spectroscopy, fluorescence quenching and molecular docking.	ferulic acid	29-41	sucrase-isomaltase	Homo sapiens	68-85
32070843-2	2020	Results indicated that ferulic acid strongly inhibited alpha-amylase (IC50: 0.622 mg ml-1) and alpha-glucosidase (IC50: 0.866 mg ml-1) by mixed and non-competitive mechanisms, respectively.	ferulic acid	23-35	sucrase-isomaltase	Homo sapiens	95-112
32070843-3	2020	CD spectra and fluorescence intensity measurements confirmed that the secondary structure of alpha-amylase and alpha-glucosidase were changed and the microenvironments of certain amino acid residues were modulated by the binding of ferulic acid.	ferulic acid	232-244	sucrase-isomaltase	Homo sapiens	111-128
32070843-4	2020	FT-IR spectra indicated that the interaction between ferulic acid and alpha-amylase/alpha-glucosidase mainly involved in non-covalent bonds.	ferulic acid	53-65	sucrase-isomaltase	Homo sapiens	84-101
32070843-5	2020	Molecular docking further demonstrated that the interaction forces between ferulic acid and alpha-amylase/alpha-glucosidase were hydrogen bonds, with the binding energy of -5.30 to -5.10 and -5.70 kcal mol-1, respectively.	ferulic acid	75-87	sucrase-isomaltase	Homo sapiens	106-123
32070843-5	2020	Molecular docking further demonstrated that the interaction forces between ferulic acid and alpha-amylase/alpha-glucosidase were hydrogen bonds, with the binding energy of -5.30 to -5.10 and -5.70 kcal mol-1, respectively.	Hydrogen	129-137	sucrase-isomaltase	Homo sapiens	106-123
32606589-1	2020	Introduction: The current study was designed to synthesize derivatives of succinimide and compare their biological potency in anticholinesterase, alpha-glucosidase inhibition, and antioxidant assays.	succinimide	74-85	sucrase-isomaltase	Homo sapiens	146-163
32194101-0	2020	In vitro study of bioaccessibility, antioxidant, and alpha-glucosidase inhibitory effect of pelargonidin-3-O-glucoside after interacting with beta-lactoglobulin and chitosan/pectin.	pelargonidin-3-glucoside	92-118	sucrase-isomaltase	Homo sapiens	53-70
32194128-5	2020	The method can also be used to determine the inhibitory effects of alpha-glucosidase inhibitors to attenuate the post-prandial blood glucose level.	Glucose	133-140	sucrase-isomaltase	Homo sapiens	67-84
32608266-2	2022	In the search for potential new anti-diabetic agents, phyllanthone along with its benzylidene and oxidation analogues were evaluated for enzyme inhibition against alpha-glucosidase.	phyllanthone	54-66	sucrase-isomaltase	Homo sapiens	163-180
32483775-4	2020	All exhibited potent alpha-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 17.6 microM, which was much lower than that of the positive control acarbose (IC50 449 microM).	Acarbose	165-173	sucrase-isomaltase	Homo sapiens	21-38
32173438-0	2020	Exploring efficacy of indole-based dual inhibitors for alpha-glucosidase and alpha-amylase enzymes: In silico, biochemical and kinetic studies.	indole	22-28	sucrase-isomaltase	Homo sapiens	55-72
32173438-4	2020	Therefore, we synthesized indole-based derivatives (1-18) and evaluated as dual inhibitor for alpha-glucosidase and alpha-amylase.	indole	26-32	sucrase-isomaltase	Homo sapiens	94-111
32301514-0	2020	Persimmon highly galloylated-tannins in vitro mitigated alpha-amylase and alpha-glucosidase via statically binding with their catalytic-closed sides and altering their secondary structure elements.	persimmon highly galloylated-tannins	0-36	sucrase-isomaltase	Homo sapiens	74-91
32301514-1	2020	Reticence of alpha-amylase (alpha-Amy) and alpha-glucosidase (alpha-Glu) is needed due to their mitigation potency on the glucose absorption.	Glutamic Acid	68-71	sucrase-isomaltase	Homo sapiens	43-60
32301514-1	2020	Reticence of alpha-amylase (alpha-Amy) and alpha-glucosidase (alpha-Glu) is needed due to their mitigation potency on the glucose absorption.	Glucose	122-129	sucrase-isomaltase	Homo sapiens	43-60
32606589-13	2020	Conclusion: Both succinimide derivatives exhibited considerable inhibitory activities against cholinesterases and alpha-glucosidase enzymes.	succinimide	17-28	sucrase-isomaltase	Homo sapiens	114-131
32105756-8	2020	There are not enough clinical data available for these phytochemicals to follow their fingerprint in human, but current studies generally recommending PAs as potent alpha-glucosidase inhibitors.	Alkaloids	151-154	sucrase-isomaltase	Homo sapiens	165-182
32327353-0	2020	Syntheses, in vitro alpha-amylase and alpha-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies.	4-amino-1,2,4-triazole	86-108	sucrase-isomaltase	Homo sapiens	38-55
31765755-0	2020	Spectroscopy and molecular docking analysis reveal structural specificity of flavonoids in the inhibition of alpha-glucosidase activity.	Flavonoids	77-87	sucrase-isomaltase	Homo sapiens	109-126
31765755-7	2020	The human alpha-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the molecular docking analysis to determine the interaction of eriocitrin and eriodictyol with the alpha-glucosidase.	Carbon	29-30	sucrase-isomaltase	Homo sapiens	10-27
31765755-7	2020	The human alpha-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the molecular docking analysis to determine the interaction of eriocitrin and eriodictyol with the alpha-glucosidase.	Carbon	29-30	sucrase-isomaltase	Homo sapiens	179-196
31765755-7	2020	The human alpha-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the molecular docking analysis to determine the interaction of eriocitrin and eriodictyol with the alpha-glucosidase.	eriocitrin	143-153	sucrase-isomaltase	Homo sapiens	10-27
31765755-7	2020	The human alpha-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the molecular docking analysis to determine the interaction of eriocitrin and eriodictyol with the alpha-glucosidase.	eriocitrin	143-153	sucrase-isomaltase	Homo sapiens	179-196
31765755-7	2020	The human alpha-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the molecular docking analysis to determine the interaction of eriocitrin and eriodictyol with the alpha-glucosidase.	eriodictyol	158-169	sucrase-isomaltase	Homo sapiens	10-27
31765755-7	2020	The human alpha-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the molecular docking analysis to determine the interaction of eriocitrin and eriodictyol with the alpha-glucosidase.	eriodictyol	158-169	sucrase-isomaltase	Homo sapiens	179-196
31765755-10	2020	This work confirmed two novel alpha-glucosidase inhibitors and provided the structure-function relationship of flavonoids in inhibition of alpha-glucosidase activity.	Flavonoids	111-121	sucrase-isomaltase	Homo sapiens	30-47
31765755-10	2020	This work confirmed two novel alpha-glucosidase inhibitors and provided the structure-function relationship of flavonoids in inhibition of alpha-glucosidase activity.	Flavonoids	111-121	sucrase-isomaltase	Homo sapiens	139-156
32061124-3	2020	Here, we show that the sucrase-isomaltase (SI)/maltase-glucoamylase (MGAM) dual enzyme system long-assumed to be the conserved disaccharide and starch digestion framework in all vertebrates is absent in many lineages.	Disaccharides	127-139	sucrase-isomaltase	Homo sapiens	23-41
32061124-3	2020	Here, we show that the sucrase-isomaltase (SI)/maltase-glucoamylase (MGAM) dual enzyme system long-assumed to be the conserved disaccharide and starch digestion framework in all vertebrates is absent in many lineages.	Disaccharides	127-139	sucrase-isomaltase	Homo sapiens	43-45
31927321-1	2020	Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, which can be counteracted by inhibition of alpha-glucosidase and alpha-amylase, both involved in the carbohydrate metabolism.	Carbohydrates	175-187	sucrase-isomaltase	Homo sapiens	117-134
32378438-0	2022	Design and synthesis of new lupeol derivatives and their alpha-glucosidase inhibitory and cytotoxic activities.	lupeol	28-34	sucrase-isomaltase	Homo sapiens	57-74
32378438-1	2022	A series of lupeol derivatives 2, 2a-2f, 2a-2h, 3a-3e, and 4a-4b were designed, synthesised and evaluated for their alpha-glucosidase inhibitory and cytotoxic activities.	lupeol	12-18	sucrase-isomaltase	Homo sapiens	116-133
32378438-2	2022	Among synthetic derivatives, lupeol analogues 2b and 2e containing a benzylidene chain exhibited the best activity against alpha-glucosidase and superior to the positive agent with the IC50 values of 29.4 +- 1.33 and 20.1 +- 0.91 muM, respectively.	lupeol	29-35	sucrase-isomaltase	Homo sapiens	123-140
32378438-2	2022	Among synthetic derivatives, lupeol analogues 2b and 2e containing a benzylidene chain exhibited the best activity against alpha-glucosidase and superior to the positive agent with the IC50 values of 29.4 +- 1.33 and 20.1 +- 0.91 muM, respectively.	benzylidene	69-80	sucrase-isomaltase	Homo sapiens	123-140
32151966-0	2020	Multifunctional isoxazolidine derivatives as alpha-amylase and alpha-glucosidase inhibitors.	Isoxazolidine	16-29	sucrase-isomaltase	Homo sapiens	63-80
32226990-0	2020	Exploring the structure-activity relationship and interaction mechanism of flavonoids and alpha-glucosidase based on experimental analysis and molecular docking studies.	Flavonoids	75-85	sucrase-isomaltase	Homo sapiens	90-107
33073027-1	2020	Glycogen storage disease type II (also known as Pompe disease (PD)) is an autosomal recessive disorder caused by defects in alpha-glucosidase (AalphaGlu), resulting in lysosomal glycogen accumulation in skeletal and heart muscles.	Glycogen	178-186	sucrase-isomaltase	Homo sapiens	124-141
32001286-0	2020	Enzymatically elongated rice starches by amylosucrase from Deinococcus geothermalis lead to slow down the glucose generation rate at the mammalian alpha-glucosidase level.	Glucose	106-113	sucrase-isomaltase	Homo sapiens	147-164
32067867-0	2020	Synthesis and biological evaluation of chepraecoxin A derivatives as alpha-glucosidase inhibitors.	chepraecoxin a	39-53	sucrase-isomaltase	Homo sapiens	69-86
32067867-1	2020	The ent-kaurane diterpenoid chepraecoxin A (CA) obtained in our previous study showed a potential inhibitory activity on alpha-glucosidase (IC50 274.5 +- 12.5 muM).	ent-7beta,11alpha,14-trihydroxy-18-aldehyde-11beta-20-epoxy-kaur-16-en15-one	4-42	sucrase-isomaltase	Homo sapiens	121-138
32067867-2	2020	In order to figure out the structure-activity relationships (SARs), twenty-two derivatives of chepraecoxin A were synthesized by modifying the ester, allyl, double bond and carboxyl groups, and assayed for their alpha-glucosidase inhibitory activity.	chepraecoxin a	94-108	sucrase-isomaltase	Homo sapiens	212-229
31927512-0	2020	Analysis of inhibitory interaction between epigallocatechin gallate and alpha-glucosidase: A spectroscopy and molecular simulation study.	epigallocatechin gallate	43-67	sucrase-isomaltase	Homo sapiens	72-89
31927512-3	2020	Certain food components have the potential to act as natural alpha-glucosidase (SCG) inhibitors, such as the polyphenols found in tea.	Polyphenols	109-120	sucrase-isomaltase	Homo sapiens	61-78
32088281-3	2020	alpha-Glucosidase, responsible for converting starch to monosaccharides, is a key therapeutic target for the management of T2D.	Starch	46-52	sucrase-isomaltase	Homo sapiens	0-17
32146175-0	2020	Synthesis, alpha-glucosidase inhibition and antioxidant activity of the 7-carbo-substituted 5-bromo-3-methylindazoles.	7-carbo-substituted 5-bromo-3-methylindazoles	72-117	sucrase-isomaltase	Homo sapiens	11-28
32146175-4	2020	Non-covalent (alkyl, pi-alkyl and pi-pi T shaped), electrostatic (pi-sulfur and/or pi-anion) and hydrogen bonding interactions are predicted to increase interactions with protein residues, thereby enhancing the inhibitory effect of these compounds against alpha-glucosidase.	Sulfur	69-75	sucrase-isomaltase	Homo sapiens	256-273
32146175-4	2020	Non-covalent (alkyl, pi-alkyl and pi-pi T shaped), electrostatic (pi-sulfur and/or pi-anion) and hydrogen bonding interactions are predicted to increase interactions with protein residues, thereby enhancing the inhibitory effect of these compounds against alpha-glucosidase.	pi-anion	83-91	sucrase-isomaltase	Homo sapiens	256-273
32120080-0	2020	Semi-synthesis of C28-modified triterpene acid derivatives from maslinic acid or corosolic acid as potential alpha-glucosidase inhibitors.	triterpene acid	31-46	sucrase-isomaltase	Homo sapiens	109-126
32120080-0	2020	Semi-synthesis of C28-modified triterpene acid derivatives from maslinic acid or corosolic acid as potential alpha-glucosidase inhibitors.	maslinic acid	64-77	sucrase-isomaltase	Homo sapiens	109-126
32120080-0	2020	Semi-synthesis of C28-modified triterpene acid derivatives from maslinic acid or corosolic acid as potential alpha-glucosidase inhibitors.	corosolic acid	81-95	sucrase-isomaltase	Homo sapiens	109-126
32088281-3	2020	alpha-Glucosidase, responsible for converting starch to monosaccharides, is a key therapeutic target for the management of T2D.	Monosaccharides	56-71	sucrase-isomaltase	Homo sapiens	0-17
32088281-6	2020	Here we report one previously unreported xanthone (5) and two known xanthones (7 and 11) as alpha-glucosidase inhibitors, isolated from an endophytic Penicillium canescens, recovered from fruits of Juniperus polycarpos.	xanthone	41-49	sucrase-isomaltase	Homo sapiens	92-109
32088281-6	2020	Here we report one previously unreported xanthone (5) and two known xanthones (7 and 11) as alpha-glucosidase inhibitors, isolated from an endophytic Penicillium canescens, recovered from fruits of Juniperus polycarpos.	Xanthones	68-77	sucrase-isomaltase	Homo sapiens	92-109
32088281-7	2020	The three xanthones 5, 7, and 11 showed inhibitory activities against alpha-glucosidase with IC50 values of 38.80 +- 1.01 muM, 32.32 +- 1.01 muM, and 75.20 +- 1.02 muM, respectively.	Xanthones	10-19	sucrase-isomaltase	Homo sapiens	70-87
32147838-5	2020	The results showed that EA fraction possesses significant free radical scavenging, alpha-amylase and alpha-glucosidase inhibition properties.	ethyl acetate	24-26	sucrase-isomaltase	Homo sapiens	101-118
32143602-0	2020	A systematic analysis of natural alpha-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology.	Flavonoids	67-77	sucrase-isomaltase	Homo sapiens	33-50
31952012-0	2020	The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting alpha-glucosidase while other phenolics modulate salivary alpha-amylase, glucose uptake and sugar transporters.	Anthocyanins	4-16	sucrase-isomaltase	Homo sapiens	96-113
33479653-0	2020	Arylsulfonyl histamine derivatives as powerful and selective alpha-glucosidase inhibitors.	arylsulfonyl histamine	0-22	sucrase-isomaltase	Homo sapiens	61-78
33479653-1	2020	A series of simple N-arylbenzenesulfonyl histamine derivatives were prepared and screened against alpha-glucosidase.	n-arylbenzenesulfonyl histamine	19-50	sucrase-isomaltase	Homo sapiens	98-115
31952012-7	2020	Taken together this suggests that the anthocyanins which are high in BC have their greatest effect on postprandial hyperglycaemia by inhibiting alpha-glucosidase activity.	Anthocyanins	38-50	sucrase-isomaltase	Homo sapiens	144-161
31952012-9	2020	Specific phenolics were also shown to inhibit salivary alpha-amylase, alpha-glucosidase, and glucose uptake.	phenolic acid	9-18	sucrase-isomaltase	Homo sapiens	70-87
31952012-10	2020	However, specific anthocyanins identified in BC which were low in GC were shown to inhibit alpha-glucosidase.	Anthocyanins	18-30	sucrase-isomaltase	Homo sapiens	91-108
31952012-11	2020	In conclusion the anthocyanins in BC appear to regulate postprandial hyperglycaemia primarily but not solely by inhibiting alpha-glucosidase while other phenolics modulate salivary alpha-amylase, glucose uptake and sugar transporters which together could lower the associated risk of developing type-2 diabetes.	Anthocyanins	18-30	sucrase-isomaltase	Homo sapiens	123-140
32143602-5	2020	METHODS: In the present study, a systematic method combining ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology was developed to screen alpha-glucosidase inhibitors from flavonoids of RS, and explore the underlying mechanism for the treatment of T2D.	Flavonoids	181-191	sucrase-isomaltase	Homo sapiens	147-164
32143602-6	2020	RESULTS: The n-butanol part of ethanol extract from RS showed a strong alpha-glucosidase inhibition activity (90.55%, IC50 0.551 mg/mL) against positive control acarbose (90.59%, IC50 1.079 mg/mL).	1-Butanol	13-22	sucrase-isomaltase	Homo sapiens	71-88
32156083-1	2020	The 5-acetyl-2-aryl-6-hydroxybenzo[b]furans 2a-h have been evaluated through in vitro enzymatic assay against targets which are linked to type 2 diabetes (T2D), namely, alpha-glucosidase, protein tyrosine phosphatase 1B (PTP1B) and beta-secretase.	5-acetyl-2-aryl-6-hydroxybenzo[b]furans 2a-h	4-48	sucrase-isomaltase	Homo sapiens	169-186
32143602-6	2020	RESULTS: The n-butanol part of ethanol extract from RS showed a strong alpha-glucosidase inhibition activity (90.55%, IC50 0.551 mg/mL) against positive control acarbose (90.59%, IC50 1.079 mg/mL).	Ethanol	31-38	sucrase-isomaltase	Homo sapiens	71-88
32143602-8	2020	Thirteen compounds were screened as alpha-glucosidase inhibitors, including viscidulin III, 2",3,5,6",7-pentahydroxyflavanone, and so on.	Ganhuangenin	76-90	sucrase-isomaltase	Homo sapiens	36-53
32143602-8	2020	Thirteen compounds were screened as alpha-glucosidase inhibitors, including viscidulin III, 2",3,5,6",7-pentahydroxyflavanone, and so on.	2",3,5,6",7-pentahydroxyflavanone	92-125	sucrase-isomaltase	Homo sapiens	36-53
32150882-0	2020	Characterizations and Assays of alpha-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the alpha-Glucosidase?	Gallic Acid	73-84	sucrase-isomaltase	Homo sapiens	176-193
32150882-7	2020	The enzyme activity evaluation results showed that both GA and glutaric acid displayed alpha-glucosidase inhibition activity, and GA-glutaric acid cocrystals showed strengthened alpha-glucosidase inhibition activity at a moderate concentration, which is attributed to synergism of the two components.	Gallic Acid	56-58	sucrase-isomaltase	Homo sapiens	87-104
32150882-0	2020	Characterizations and Assays of alpha-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the alpha-Glucosidase?	Gallic Acid	73-84	sucrase-isomaltase	Homo sapiens	32-49
32150882-7	2020	The enzyme activity evaluation results showed that both GA and glutaric acid displayed alpha-glucosidase inhibition activity, and GA-glutaric acid cocrystals showed strengthened alpha-glucosidase inhibition activity at a moderate concentration, which is attributed to synergism of the two components.	glutaric acid	63-76	sucrase-isomaltase	Homo sapiens	87-104
32150882-7	2020	The enzyme activity evaluation results showed that both GA and glutaric acid displayed alpha-glucosidase inhibition activity, and GA-glutaric acid cocrystals showed strengthened alpha-glucosidase inhibition activity at a moderate concentration, which is attributed to synergism of the two components.	Gallic Acid	130-132	sucrase-isomaltase	Homo sapiens	178-195
32150882-7	2020	The enzyme activity evaluation results showed that both GA and glutaric acid displayed alpha-glucosidase inhibition activity, and GA-glutaric acid cocrystals showed strengthened alpha-glucosidase inhibition activity at a moderate concentration, which is attributed to synergism of the two components.	glutaric acid	133-146	sucrase-isomaltase	Homo sapiens	178-195
32150882-8	2020	Molecular docking displayed that the GA-glutaric acid complex deeply entered the active cavity of the alpha-glucosidase in the form of a supramolecule, which made the guest-enzyme binding configuration more stable.	ga-glutaric acid	37-53	sucrase-isomaltase	Homo sapiens	102-119
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	succinimide	15-26	sucrase-isomaltase	Homo sapiens	300-317
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	succinimide	35-46	sucrase-isomaltase	Homo sapiens	300-317
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	ga-succinimide	98-112	sucrase-isomaltase	Homo sapiens	147-164
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	ga-succinimide	98-112	sucrase-isomaltase	Homo sapiens	300-317
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	Gallic Acid	98-100	sucrase-isomaltase	Homo sapiens	147-164
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	Gallic Acid	98-100	sucrase-isomaltase	Homo sapiens	300-317
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	succinimide	35-46	sucrase-isomaltase	Homo sapiens	300-317
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	ga-succinimide	356-370	sucrase-isomaltase	Homo sapiens	147-164
32150882-9	2020	For the GA and succinimide system, succinimide showed no enzyme inhibition activity, however, the GA-succinimide complex presented slightly higher alpha-glucosidase inhibition activity than that of GA. Molecular docking simulation indicated that the guest molecules entering the active cavity of the alpha-glucosidase were free GA and succinimide, not the GA-succinimide supramolecule.	ga-succinimide	356-370	sucrase-isomaltase	Homo sapiens	300-317
31978686-0	2020	Dihydropyridines as potential alpha-amylase and alpha-glucosidase inhibitors: Synthesis, in vitro and in silico studies.	1,4-dihydropyridine	0-16	sucrase-isomaltase	Homo sapiens	48-65
32154416-0	2020	Inhibitory effect of Artocarpus lakoocha Roxb and oxyresveratrol on alpha-glucosidase and sugar digestion in Caco-2 cells.	puag-haad	50-64	sucrase-isomaltase	Homo sapiens	68-85
32154416-1	2020	Long-term diabetic complications are exacerbated by post-prandial hyperglycemia which could be ameliorated by alpha-glucosidase inhibitor including oxyresveratrol.	puag-haad	148-162	sucrase-isomaltase	Homo sapiens	110-127
32154416-4	2020	Oxyresveratrol is an inhibitor of isolated yeast alpha-glucosidase enzyme but has not been tested on intact gut enterocytes where the enzyme is membrane-bound.	puag-haad	0-14	sucrase-isomaltase	Homo sapiens	49-66
32154416-6	2020	The results demonstrated that purified yeast alpha-glucosidase was non-competitively inhibited by oxyresveratrol (Ki 54.4 +- 0.7 mug/mL) and Puag-Haad (2.7 +- 0.1 mug/mL) compared to 153.8 +- 4.3 mug/mL acarbose, an anti-diabetic drug.	puag-haad	98-112	sucrase-isomaltase	Homo sapiens	45-62
32154416-6	2020	The results demonstrated that purified yeast alpha-glucosidase was non-competitively inhibited by oxyresveratrol (Ki 54.4 +- 0.7 mug/mL) and Puag-Haad (2.7 +- 0.1 mug/mL) compared to 153.8 +- 4.3 mug/mL acarbose, an anti-diabetic drug.	Acarbose	203-211	sucrase-isomaltase	Homo sapiens	45-62
31741084-0	2020	Structural effect of amine N-oxides on the facilitation of alpha-glucosidase-catalyzed hydrolysis reactions.	N,N-dimethyl-2-propyn-1-amine N-oxide	21-35	sucrase-isomaltase	Homo sapiens	59-76
31741084-4	2020	It was revealed that synthetic amine N-oxides structure-dependently activate alpha-glucosidase-catalyzed hydrolysis reactions similarly to betaines.	N,N-dimethyl-2-propyn-1-amine N-oxide	31-45	sucrase-isomaltase	Homo sapiens	77-94
31978686-1	2020	Dihydropyridine derivatives 1-31 were synthesized via one-pot solvent free condition and screened for in vitro against alpha-amylase and alpha-glucosidase enzyme.	1,4-dihydropyridine	0-15	sucrase-isomaltase	Homo sapiens	137-154
32521929-14	2020	IC50 value for alpha-glucosidase inhibitory activity was much stronger than standard acarbose.	Acarbose	85-93	sucrase-isomaltase	Homo sapiens	15-32
31972390-0	2020	Synthesis and biological evaluation of coumarin derivatives as alpha-glucosidase inhibitors.	coumarin	39-47	sucrase-isomaltase	Homo sapiens	63-80
31972390-1	2020	In this study, two series of coumarin derivatives 5a~i and 6a~i were synthesized, and their inhibitory activity against alpha-glucosidase was determined.	coumarin	29-37	sucrase-isomaltase	Homo sapiens	120-137
31972390-6	2020	The docking studies showed that compound 5b could be inserted into the active pocket of alpha-glucosidase and form hydrogen bonds with LYS293 to enhance the binding affinity.	Hydrogen	115-123	sucrase-isomaltase	Homo sapiens	88-105
32093426-0	2020	Alpha-Glucosidase- and Lipase-Inhibitory Phenalenones from a New Species of Pseudolophiostoma Originating from Thailand.	phenalen-1-one	41-53	sucrase-isomaltase	Homo sapiens	0-29
32180813-0	2020	Synthesis and inhibitory activity of N-acetylpyrrolidine derivatives on alpha-glucosidase and alpha-amylase.	1-Acetylpyrrolidine	37-56	sucrase-isomaltase	Homo sapiens	72-89
32054916-0	2020	An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with alpha-glucosidase inhibitory activity.	pyrazolo(1,5-a)pyrimidine	76-110	sucrase-isomaltase	Homo sapiens	116-133
32180813-3	2020	Experimental approach: N-substituted-acetylpyrrolidine linked with -benzyl- (N-(benzyl)-2-acetylpyrrolidine (4a)) and -tosyl- (N-(tosyl)-2-acetylpyrrolidine (4b)) were synthesized and evaluated for their pharmaceutical properties against alpha-glucosidase and alpha-amylase and free radical scavenging activity.	n-substituted-acetylpyrrolidine	23-54	sucrase-isomaltase	Homo sapiens	238-255
32180813-9	2020	Conclusion and implications: Our results indicated that a derivative of N-substitute-acetylpyrrolidine had high potential to inhibit alpha-glucosidase and alpha-amylase, and their free radical scavenging properties might be applied to the therapeutic care of patients with type 2 diabetes mellitus.	n-substitute-acetylpyrrolidine	72-102	sucrase-isomaltase	Homo sapiens	133-150
32079363-8	2020	The ethyl acetate extract was the most active acetylcholinesterase (4.43 mg galantamine equivalent/g extract) and alpha-glucosidase (mmol acarbose equivalent /g extract) inhibitor.	ethyl acetate	4-17	sucrase-isomaltase	Homo sapiens	114-131
32054916-1	2020	In an attempt to find novel alpha-glucosidase inhibitors, an efficient, straightforward reaction to synthesize a library of fully substituted 6-amino-pyrazolo[1,5-a]pyrimidines 3 has been investigated.	pyrazolo(1,5-a)pyrimidine	142-176	sucrase-isomaltase	Homo sapiens	28-45
31751818-0	2020	Molecular docking of polyoxometalates as potential alpha-glucosidase inhibitors.	polyoxometalate I	21-37	sucrase-isomaltase	Homo sapiens	51-68
31493040-4	2020	SID is a condition in which sucrase-isomaltase, an enzyme produced by brush border of small intestine to metabolize sucrose, is deficient.	Sucrose	116-123	sucrase-isomaltase	Homo sapiens	28-46
31751818-2	2020	In our previous studies, it was found that polyoxometalates exhibited an effective inhibitory effect on the activity of alpha-glucosidase, while polyoxometalates have the characteristics of structural diversity and unique properties.	polyoxometalate I	43-59	sucrase-isomaltase	Homo sapiens	120-137
31751818-4	2020	The results demonstrated that all of the studied compounds had a significant inhibitory ability on alpha-glucosidase as compared with the positive control acarbose.	Acarbose	155-163	sucrase-isomaltase	Homo sapiens	99-116
32013559-7	2021	Samples showed a low capacity to inhibit alpha-amylase, but a high alpha-glucosidase inhibition was obtained with the root"s and flower"s ethanol extracts, and flower"s methanol extract.	Ethanol	138-145	sucrase-isomaltase	Homo sapiens	67-84
32013559-7	2021	Samples showed a low capacity to inhibit alpha-amylase, but a high alpha-glucosidase inhibition was obtained with the root"s and flower"s ethanol extracts, and flower"s methanol extract.	Methanol	169-177	sucrase-isomaltase	Homo sapiens	67-84
31844870-2	2020	Alpha-glucosidase has been considered as the main target enzyme in the prevention and treatment of type 2 diabetes, and the inhibition of alpha-glucosidase activity can control postprandial blood glucose levels of diabetics and keep blood glucose levels normal.	Glucose	196-203	sucrase-isomaltase	Homo sapiens	0-17
31751818-5	2020	H8[P2Mo17Cr(OH2)O61] reversibly inhibited alpha-glucosidase in a competitive manner with IC50 of 115.50 +- 1.64 muM and KI value of 44.31 muM.	PM-17 polyoxomolybdate	0-20	sucrase-isomaltase	Homo sapiens	42-59
31751818-8	2020	We conducted molecular docking study and found that the compound and alpha-glucosidase were mainly non-covalently interacting with hydrogen bonds and van der Waals forces.	Hydrogen	131-139	sucrase-isomaltase	Homo sapiens	69-86
30825061-0	2020	Design and synthesis of new imidazo[1,2-b]pyrazole derivatives, in vitro alpha-glucosidase inhibition, kinetic and docking studies.	1H-Imidazo[1,2-b]pyrazole	28-50	sucrase-isomaltase	Homo sapiens	73-90
30825061-1	2020	A new series of imidazo[1,2-b]pyrazole derivatives 4a-o was designed, synthesized, and screened for in vitro alpha-glucosidase inhibitory activity.	1H-Imidazo[1,2-b]pyrazole	16-38	sucrase-isomaltase	Homo sapiens	109-126
30825061-4	2020	Like acarbose, compound 4j inhibited alpha-glucosidase in a competitive mode.	Acarbose	5-13	sucrase-isomaltase	Homo sapiens	37-54
31844870-2	2020	Alpha-glucosidase has been considered as the main target enzyme in the prevention and treatment of type 2 diabetes, and the inhibition of alpha-glucosidase activity can control postprandial blood glucose levels of diabetics and keep blood glucose levels normal.	Glucose	196-203	sucrase-isomaltase	Homo sapiens	138-155
31844870-2	2020	Alpha-glucosidase has been considered as the main target enzyme in the prevention and treatment of type 2 diabetes, and the inhibition of alpha-glucosidase activity can control postprandial blood glucose levels of diabetics and keep blood glucose levels normal.	Glucose	239-246	sucrase-isomaltase	Homo sapiens	0-17
31844870-2	2020	Alpha-glucosidase has been considered as the main target enzyme in the prevention and treatment of type 2 diabetes, and the inhibition of alpha-glucosidase activity can control postprandial blood glucose levels of diabetics and keep blood glucose levels normal.	Glucose	239-246	sucrase-isomaltase	Homo sapiens	138-155
32089234-6	2020	In T2D, management of post-prandial blood glucose by modulating alpha-glucosidase or alpha-amylase activities, modulation of the AMPK signaling pathway, and similarly to obesity, reduction of ROS and NO production with subsequent increased expression of antioxidant enzymes have been shown to play a key role in glucose metabolism and insulin signaling.	Glucose	42-49	sucrase-isomaltase	Homo sapiens	64-81
31816382-0	2020	Interaction mechanism between alpha-glucosidase and A-type trimer procyanidin revealed by integrated spectroscopic analysis techniques.	procyanidin	66-77	sucrase-isomaltase	Homo sapiens	30-47
31816382-1	2020	alpha-Glucosidase is an important enzyme in human intestine, and inhibition of its activity can lower blood sugar levels to effectively prevent hyperglycaemia induced tissue damage.	Blood Glucose	102-113	sucrase-isomaltase	Homo sapiens	0-17
31816382-2	2020	Here, we investigated the inhibitory activities of procyanidins with different structures on alpha-glucosidase and the underlying mechanism.	Proanthocyanidins	51-63	sucrase-isomaltase	Homo sapiens	93-110
31816382-3	2020	The results showed that the IC50 of catechin and compounds 2-7 on alpha-glucosidase was lower than that of acarbose.	Catechin	36-44	sucrase-isomaltase	Homo sapiens	66-83
31816382-10	2020	The results demonstrate the ability of procyanidins to intervene in the progression of type 2 diabetes by inhibiting alpha-glucosidase.	Proanthocyanidins	39-51	sucrase-isomaltase	Homo sapiens	117-134
31936396-0	2020	Meroterpene-Like alpha-Glucosidase Inhibitors Based on Biomimetic Reactions Starting from beta-Caryophyllene.	meroterpene	0-11	sucrase-isomaltase	Homo sapiens	17-34
31936396-0	2020	Meroterpene-Like alpha-Glucosidase Inhibitors Based on Biomimetic Reactions Starting from beta-Caryophyllene.	caryophyllene	90-108	sucrase-isomaltase	Homo sapiens	17-34
31936396-1	2020	BACKGROUND: Natural meroterpenes derived from phloroglucinols and beta-caryophyllene have shown high inhibitory activity against alpha-glucosidase or cancer cells, however, the chemical diversity of this type of skeletons in Nature is limited.	meroterpenes	20-32	sucrase-isomaltase	Homo sapiens	129-146
31936396-1	2020	BACKGROUND: Natural meroterpenes derived from phloroglucinols and beta-caryophyllene have shown high inhibitory activity against alpha-glucosidase or cancer cells, however, the chemical diversity of this type of skeletons in Nature is limited.	Phloroglucinol	46-61	sucrase-isomaltase	Homo sapiens	129-146
31936396-1	2020	BACKGROUND: Natural meroterpenes derived from phloroglucinols and beta-caryophyllene have shown high inhibitory activity against alpha-glucosidase or cancer cells, however, the chemical diversity of this type of skeletons in Nature is limited.	caryophyllene	66-84	sucrase-isomaltase	Homo sapiens	129-146
31936396-2	2020	METHODS: To expand the chemical space and explore their inhibitory activities against alpha-glucosidase (EC 3.2.1.20), we employed beta-caryophyllene and some natural moieties (4-hydroxycoumarins, lawsone or syncarpic acid) to synthesize new types of meroterpene-like skeletons.	caryophyllene	131-149	sucrase-isomaltase	Homo sapiens	86-103
31901900-3	2020	Using biochemical assays, computer-aided docking/molecular dynamics simulations, and fluorescence microscopy, we found that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (alpha-glucosidase/alpha-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1.	Resveratrol	124-127	sucrase-isomaltase	Homo sapiens	197-214
31901900-3	2020	Using biochemical assays, computer-aided docking/molecular dynamics simulations, and fluorescence microscopy, we found that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (alpha-glucosidase/alpha-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1.	Nitrogen	248-249	sucrase-isomaltase	Homo sapiens	197-214
31901900-3	2020	Using biochemical assays, computer-aided docking/molecular dynamics simulations, and fluorescence microscopy, we found that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (alpha-glucosidase/alpha-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1.	linked glycan	250-263	sucrase-isomaltase	Homo sapiens	197-214
31901900-3	2020	Using biochemical assays, computer-aided docking/molecular dynamics simulations, and fluorescence microscopy, we found that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (alpha-glucosidase/alpha-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1.	Mannose	344-351	sucrase-isomaltase	Homo sapiens	197-214
31675649-5	2020	The activities of alpha-glucosidase and protease increased by 8.8% and 21.3% respectively in the presence of 0.4 g/g TSS APG comparing no APG addition.	Alkanesulfonates	121-124	sucrase-isomaltase	Homo sapiens	18-35
31699396-0	2020	Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study.	benzimidazole	62-75	sucrase-isomaltase	Homo sapiens	20-37
31699396-0	2020	Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study.	Schiff Bases	84-100	sucrase-isomaltase	Homo sapiens	20-37
31699396-1	2020	Voglibose and acarbose are distinguished alpha-glucosidase inhibitors used for controlling of diabetes mellitus.	voglibose	0-9	sucrase-isomaltase	Homo sapiens	41-58
31699396-1	2020	Voglibose and acarbose are distinguished alpha-glucosidase inhibitors used for controlling of diabetes mellitus.	Acarbose	14-22	sucrase-isomaltase	Homo sapiens	41-58
31699396-5	2020	Current study deals with the synthesis and biological screening of benzimidazole bearing bis-Schiff bases (1-19) for their alpha-glucosidase inhibitory activity.	benzimidazole	67-80	sucrase-isomaltase	Homo sapiens	123-140
31699396-5	2020	Current study deals with the synthesis and biological screening of benzimidazole bearing bis-Schiff bases (1-19) for their alpha-glucosidase inhibitory activity.	Schiff Bases	89-105	sucrase-isomaltase	Homo sapiens	123-140
31818480-0	2020	Synthesis and molecular docking studies of imines as alpha-glucosidase and alpha-amylase inhibitors.	Imines	43-49	sucrase-isomaltase	Homo sapiens	53-70
31818480-6	2020	All aryl imines synthesized were evaluated for in vitro inhibitory potential against alpha-glucosidase and alpha-amylase enzymes and the results exhibited that the most of the compounds displayed inhibitory activity against both enzymes.	Imines	4-15	sucrase-isomaltase	Homo sapiens	85-102
31818480-7	2020	The (E)-1-(4-nitrophenyl)-N-(pyridin-2-yl)methanimine (3d) was 1.15-fold more active than acarbose against alpha-amylase whilst the (E)-1-phenyl-N-(pyridin-2-yl)methanimine (3c) displayed similar activity that acarbose against alpha-glucosidase.	methyleneimine	8-53	sucrase-isomaltase	Homo sapiens	227-244
31818480-8	2020	The molecular docking studies in alpha-glucosidase and alpha-amylase reveal that aryl imines mainly establish an H-bond with the R2-subtituent and hydrophobic interactions with the R1-subtituent.	Imines	81-92	sucrase-isomaltase	Homo sapiens	33-50
31451297-0	2020	Synthesis of new indazole based dual inhibitors of alpha-glucosidase and alpha-amylase enzymes, their in vitro, in silico and kinetics studies.	Indazoles	17-25	sucrase-isomaltase	Homo sapiens	51-68
31675649-5	2020	The activities of alpha-glucosidase and protease increased by 8.8% and 21.3% respectively in the presence of 0.4 g/g TSS APG comparing no APG addition.	Alkanesulfonates	138-141	sucrase-isomaltase	Homo sapiens	18-35
32851955-7	2020	Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products and inhibition of the the alpha-glucosidase enzyme.	Flavonoids	10-20	sucrase-isomaltase	Homo sapiens	287-304
31838286-1	2020	In this study, a series of benzimidazole-1,2,3-triazole hybrids 8a-n as new alpha-glucosidase inhibitors were designed and synthesized.	benzimidazole	27-55	sucrase-isomaltase	Homo sapiens	76-93
31838286-2	2020	In vitro alpha-glucosidase inhibition activity results indicated that all the synthesized compounds (IC50 values ranging from 25.2 +- 0.9 to 176.5 +- 6.7 muM) exhibited more inhibitory activity in comparison to standard drug acarbose (IC50 = 750.0 +- 12.5 muM).	Acarbose	225-233	sucrase-isomaltase	Homo sapiens	9-26
31838286-0	2020	Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential alpha-glucosidase inhibitors.	benzimidazole	43-71	sucrase-isomaltase	Homo sapiens	93-110
30638035-0	2020	The inhibitory effects of flavonoids on alpha-amylase and alpha-glucosidase.	Flavonoids	26-36	sucrase-isomaltase	Homo sapiens	58-75
30638035-1	2020	The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of flavonoids on alpha-amylase (alphaA) and alpha-glucosidase (alphaG) relevant to the search of substitutes of acarbose (Aca).	Flavonoids	90-100	sucrase-isomaltase	Homo sapiens	131-148
30799629-6	2020	We can conclude that the retarded starch digestion in vitro by polyphenols results from inhibition of key digestive enzymes, including alpha-amylase and alpha-glucosidase, as well as from interactions between polyphenols and starch.	Starch	34-40	sucrase-isomaltase	Homo sapiens	153-170
30799629-6	2020	We can conclude that the retarded starch digestion in vitro by polyphenols results from inhibition of key digestive enzymes, including alpha-amylase and alpha-glucosidase, as well as from interactions between polyphenols and starch.	Polyphenols	63-74	sucrase-isomaltase	Homo sapiens	153-170
31724206-3	2020	This study aims to investigate the antidiabetic properties and anti-melanin synthesis of capsaicinoids by studying the inhibitory activity of capsaicin and dihydrocapsaicin with alpha-glucosidase, alpha-amylase, and tyrosinase.	dihydrocapsaicin	156-172	sucrase-isomaltase	Homo sapiens	178-195
31724206-4	2020	The results revealed that dihydrocapsaicin with IC50 had 4.13-fold and 3.00-fold for alpha-glucosidase and alpha-amylase, respectively, which are lower than capsaicin.	dihydrocapsaicin	26-42	sucrase-isomaltase	Homo sapiens	85-102
31724206-4	2020	The results revealed that dihydrocapsaicin with IC50 had 4.13-fold and 3.00-fold for alpha-glucosidase and alpha-amylase, respectively, which are lower than capsaicin.	Capsaicin	33-42	sucrase-isomaltase	Homo sapiens	85-102
31724206-6	2020	The inhibition constant (Ki ) also supported that the dihydrocapsaicin had higher inhibitory activity than capsaicin against alpha-glucosidase and alpha-amylase, but lower inhibitory activity than capsaicin on tyrosinase.	dihydrocapsaicin	54-70	sucrase-isomaltase	Homo sapiens	125-142
31724206-6	2020	The inhibition constant (Ki ) also supported that the dihydrocapsaicin had higher inhibitory activity than capsaicin against alpha-glucosidase and alpha-amylase, but lower inhibitory activity than capsaicin on tyrosinase.	Capsaicin	61-70	sucrase-isomaltase	Homo sapiens	125-142
31724206-6	2020	The inhibition constant (Ki ) also supported that the dihydrocapsaicin had higher inhibitory activity than capsaicin against alpha-glucosidase and alpha-amylase, but lower inhibitory activity than capsaicin on tyrosinase.	Capsaicin	107-116	sucrase-isomaltase	Homo sapiens	125-142
31724206-9	2020	PRACTICAL APPLICATIONS: This study presents the inhibition potential of capsaicin and dihydrocapsaicin on antidiabetes and anti-melanin properties by standard methods for inhibitory activity against alpha-glucosidase, alpha-amylase, and tyrosinase.	Capsaicin	72-81	sucrase-isomaltase	Homo sapiens	199-216
31724206-9	2020	PRACTICAL APPLICATIONS: This study presents the inhibition potential of capsaicin and dihydrocapsaicin on antidiabetes and anti-melanin properties by standard methods for inhibitory activity against alpha-glucosidase, alpha-amylase, and tyrosinase.	dihydrocapsaicin	86-102	sucrase-isomaltase	Homo sapiens	199-216
32435124-4	2020	Among the synthesized derivatives, 4e (IC50 = 6.71 mug/mL) was found to be more potent against alpha-glucosidase enzyme as compared with the standard Acarbose (IC50 = 9.35 mug/mL) and 4i (IC50 = 11.90 mug/mL) exhibited good inhibitory activity against alpha-amylase enzyme as compared with the standard Acarbose (IC50 = 22.87 mug/mL).	Acarbose	150-158	sucrase-isomaltase	Homo sapiens	95-112
31195948-0	2020	Synthesis, In vitro alpha-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives.	2-amino-1,3,4-oxadiazole	92-116	sucrase-isomaltase	Homo sapiens	20-37
32435124-4	2020	Among the synthesized derivatives, 4e (IC50 = 6.71 mug/mL) was found to be more potent against alpha-glucosidase enzyme as compared with the standard Acarbose (IC50 = 9.35 mug/mL) and 4i (IC50 = 11.90 mug/mL) exhibited good inhibitory activity against alpha-amylase enzyme as compared with the standard Acarbose (IC50 = 22.87 mug/mL).	Acarbose	303-311	sucrase-isomaltase	Homo sapiens	95-112
32560604-0	2020	Structure-activity Relationships of Natural and Synthetic Indole-derived Scaffolds as alpha-Glucosidase Inhibitors: A Mini-review.	indole	58-64	sucrase-isomaltase	Homo sapiens	86-103
31195948-1	2020	BACKGROUND: In the recent past, we had synthesized and reported different derivatives of oxadiazoles as potential alpha-glucosidase inhibitors.	Oxadiazoles	89-100	sucrase-isomaltase	Homo sapiens	114-131
31195949-4	2020	To predict the interactions of 2-mercapto benzothiazole derivatives 1-33 with the binding pocket of alpha-glucosidase enzyme, molecular docking studies were performed on the selected inhibitors.	captax	31-55	sucrase-isomaltase	Homo sapiens	100-117
31195949-5	2020	RESULTS: Compounds 2-4, 6-7, 9-26, 28 and 30 showed many folds potent alpha-glucosidase inhibitory activity in the range of IC50 = 31.21-208.63 muM, as compared to the standard drug acarbose (IC50 = 875.75 +- 2.08 muM).	Acarbose	182-190	sucrase-isomaltase	Homo sapiens	70-87
31553294-0	2020	Coumarin-based Scaffold as alpha-glucosidase Inhibitory Activity: Implication for Development of Potent Antidiabetic Agents.	coumarin	0-8	sucrase-isomaltase	Homo sapiens	27-44
31553294-1	2020	Delaying the absorption of glucose through alpha-glucosidase enzymes inhibition is one of the therapeutic approaches in the management of Type 2 diabetes, which can reduce the incidence of postprandial hyperglycemia.	Glucose	27-34	sucrase-isomaltase	Homo sapiens	43-60
31553294-3	2020	The currently available alpha-glucosidase inhibitors, for instance, acarbose have some side effects such as hypoglycemia at higher doses, liver problems, meteorism, diarrhea, and lactic acidosis.	Acarbose	68-76	sucrase-isomaltase	Homo sapiens	24-41
31553294-6	2020	Among them, coumarin scaffold has attracted great attention, which can be isolated from various natural products and/or synthesized for the development of novel alpha-glucosidase inhibitors.	coumarin	12-20	sucrase-isomaltase	Homo sapiens	161-178
31553294-7	2020	Therefore, this review describes the applications of coumarin-containing derivatives based on published reports as alpha-glucosidase inhibitors and will be useful for innovative approaches in the search for novel coumarin-based antidiabetic drugs with less toxicity and more potency.	coumarin	53-61	sucrase-isomaltase	Homo sapiens	115-132
31553294-7	2020	Therefore, this review describes the applications of coumarin-containing derivatives based on published reports as alpha-glucosidase inhibitors and will be useful for innovative approaches in the search for novel coumarin-based antidiabetic drugs with less toxicity and more potency.	coumarin	213-221	sucrase-isomaltase	Homo sapiens	115-132
32560604-1	2020	alpha-Glucosidase plays an important role in carbohydrate metabolism and is an attractive drug target for the treatment of diabetes, obesity and other related complications.	Carbohydrates	45-57	sucrase-isomaltase	Homo sapiens	0-17
32560604-2	2020	Currently, acarbose, miglitol and voglibose have been approved by FDA as treatment of diabetes by oral alpha-glucosidase inhibitors.	Acarbose	11-19	sucrase-isomaltase	Homo sapiens	103-120
32560604-2	2020	Currently, acarbose, miglitol and voglibose have been approved by FDA as treatment of diabetes by oral alpha-glucosidase inhibitors.	miglitol	21-29	sucrase-isomaltase	Homo sapiens	103-120
32560604-2	2020	Currently, acarbose, miglitol and voglibose have been approved by FDA as treatment of diabetes by oral alpha-glucosidase inhibitors.	voglibose	34-43	sucrase-isomaltase	Homo sapiens	103-120
32560604-7	2020	In the last decade, the discovery of natural or synthetic indole derivatives possessing the inhibitory activity of alpha-glucosidase has received great attentions.	indole	58-64	sucrase-isomaltase	Homo sapiens	115-132
31670357-0	2019	A label-free fluorescent sensor based on silicon quantum dots-MnO2 nanosheets for the detection of alpha-glucosidase and its inhibitor.	Silicon	41-48	sucrase-isomaltase	Homo sapiens	99-116
31670357-0	2019	A label-free fluorescent sensor based on silicon quantum dots-MnO2 nanosheets for the detection of alpha-glucosidase and its inhibitor.	manganese dioxide	62-66	sucrase-isomaltase	Homo sapiens	99-116
31670357-2	2019	In the present work, we established a facile, sensitive and selective fluorescence method based on silicon quantum dots (SiQDs) and MnO2 nanosheets for the determination of alpha-glucosidase and one of its inhibitors acarbose.	Silicon	99-106	sucrase-isomaltase	Homo sapiens	173-190
31670357-2	2019	In the present work, we established a facile, sensitive and selective fluorescence method based on silicon quantum dots (SiQDs) and MnO2 nanosheets for the determination of alpha-glucosidase and one of its inhibitors acarbose.	manganese dioxide	132-136	sucrase-isomaltase	Homo sapiens	173-190
31670357-2	2019	In the present work, we established a facile, sensitive and selective fluorescence method based on silicon quantum dots (SiQDs) and MnO2 nanosheets for the determination of alpha-glucosidase and one of its inhibitors acarbose.	Acarbose	217-225	sucrase-isomaltase	Homo sapiens	173-190
31670357-4	2019	alpha-Glucosidase could easily catalyze the hydrolysis of l-ascorbic acid-2-O-alpha-d-glucopyranosyl (AAG) to produce ascorbic acid (AA), which could reduce MnO2 nanosheets to Mn2+, resulting in dramatic recovery of the fluorescence of SiQDs.	ascorbic acid 2-O-glucoside	58-100	sucrase-isomaltase	Homo sapiens	0-17
31670357-4	2019	alpha-Glucosidase could easily catalyze the hydrolysis of l-ascorbic acid-2-O-alpha-d-glucopyranosyl (AAG) to produce ascorbic acid (AA), which could reduce MnO2 nanosheets to Mn2+, resulting in dramatic recovery of the fluorescence of SiQDs.	aag	102-105	sucrase-isomaltase	Homo sapiens	0-17
31670357-4	2019	alpha-Glucosidase could easily catalyze the hydrolysis of l-ascorbic acid-2-O-alpha-d-glucopyranosyl (AAG) to produce ascorbic acid (AA), which could reduce MnO2 nanosheets to Mn2+, resulting in dramatic recovery of the fluorescence of SiQDs.	Ascorbic Acid	60-73	sucrase-isomaltase	Homo sapiens	0-17
31670357-4	2019	alpha-Glucosidase could easily catalyze the hydrolysis of l-ascorbic acid-2-O-alpha-d-glucopyranosyl (AAG) to produce ascorbic acid (AA), which could reduce MnO2 nanosheets to Mn2+, resulting in dramatic recovery of the fluorescence of SiQDs.	manganese dioxide	157-161	sucrase-isomaltase	Homo sapiens	0-17
31670357-4	2019	alpha-Glucosidase could easily catalyze the hydrolysis of l-ascorbic acid-2-O-alpha-d-glucopyranosyl (AAG) to produce ascorbic acid (AA), which could reduce MnO2 nanosheets to Mn2+, resulting in dramatic recovery of the fluorescence of SiQDs.	Manganese(2+)	176-180	sucrase-isomaltase	Homo sapiens	0-17
31585262-0	2019	Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent alpha-glucosidase inhibitors.	Pyrazoles	97-124	sucrase-isomaltase	Homo sapiens	143-160
31874099-3	2019	Background This study evaluates the antioxidant activity and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa leaves on alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, arginase, phosphodiesterase 5 (PDE-5), and angiotensin converting enzyme (ACE).	1-Butanol	97-106	sucrase-isomaltase	Homo sapiens	160-177
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	sucrase-isomaltase	Homo sapiens	61-78
31679980-0	2019	Design, synthesis, in vitro, and in silico studies of novel diarylimidazole-1,2,3-triazole hybrids as potent alpha-glucosidase inhibitors.	Triazoles	60-90	sucrase-isomaltase	Homo sapiens	109-126
31679980-1	2019	In this work, new derivatives of diarylimidazole-1,2,3-triazole 7a-p were designed, synthesized, and evaluated for their in vitro alpha-glucosidase inhibitory activity.	Triazoles	33-63	sucrase-isomaltase	Homo sapiens	130-147
31808389-1	2021	BACKGROUND: Chalcones, originated from natural product, have been broadly studied their biological activity against various proteins which at the molecular level, are responsible for the progress of the diseases in cancer (e.g. kinases), inflammation (oxidoreductases), atherosclerosis (cathepsins receptor), and diabetes (e.g. alpha-glucosidase).	Chalcones	12-21	sucrase-isomaltase	Homo sapiens	328-345
31808390-0	2021	Study on the interaction of 1,5-diaryl pyrrole derivatives with alpha-glucosidase; synthesis, molecular docking, and kinetic study.	Diarylquinolines	28-46	sucrase-isomaltase	Homo sapiens	64-81
31808390-2	2021	alpha-glucosidase inhibitors compete with the alpha-glucosidase enzyme activity, which helps to reduce the conversion of carbohydrates into glucose and thereby control the postprandial hyperglycemia incidence.	Carbohydrates	121-134	sucrase-isomaltase	Homo sapiens	0-17
31808390-2	2021	alpha-glucosidase inhibitors compete with the alpha-glucosidase enzyme activity, which helps to reduce the conversion of carbohydrates into glucose and thereby control the postprandial hyperglycemia incidence.	Carbohydrates	121-134	sucrase-isomaltase	Homo sapiens	46-63
31808390-2	2021	alpha-glucosidase inhibitors compete with the alpha-glucosidase enzyme activity, which helps to reduce the conversion of carbohydrates into glucose and thereby control the postprandial hyperglycemia incidence.	Glucose	140-147	sucrase-isomaltase	Homo sapiens	0-17
31808390-2	2021	alpha-glucosidase inhibitors compete with the alpha-glucosidase enzyme activity, which helps to reduce the conversion of carbohydrates into glucose and thereby control the postprandial hyperglycemia incidence.	Glucose	140-147	sucrase-isomaltase	Homo sapiens	46-63
31808390-3	2021	OBJECTIVE: The aim of this study was to synthesize a series of novel 1,5-diphenyl pyrrole derivatives and evaluate their in vitro alpha-glucosidase inhibitory activities.	Pyrroles	69-89	sucrase-isomaltase	Homo sapiens	130-147
31808390-6	2021	RESULTS: Synthesized compounds showed good in vitro alpha-glucosidase inhibitory activity with IC50 values in the range of (117.5 +- 3.8 to 426.0 +- 10.2 microM) as compared to acarbose, the standard drug, (750 +- 8.7 microM).	Acarbose	177-185	sucrase-isomaltase	Homo sapiens	52-69
31544284-0	2019	A novel five-step synthetic route to 1,3,4-oxadiazole derivatives with potent alpha-glucosidase inhibitory potential and their in silico studies.	1,3,4-oxadiazole	37-53	sucrase-isomaltase	Homo sapiens	78-95
31609028-1	2019	A novel series of N"-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazides were synthesized and studied for their alpha-glucosidase inhibition activity.	L 741519	18-74	sucrase-isomaltase	Homo sapiens	165-182
31506889-8	2019	CONCLUSION: Canagliflozin 100 mg increased postprandial total GLP-1 levels in the absence of acarbose, suggesting that it may upregulate GLP-1 secretion through delayed glucose absorption in the upper intestine, as with the alpha-glucosidase inhibitor.	Canagliflozin	12-25	sucrase-isomaltase	Homo sapiens	224-241
31585262-1	2019	The aim of the present study is to design and synthesis of new pyrazole-triazolopyrimidine hybrids as potent alpha-glucosidase inhibitors.	Pyrazoles	63-90	sucrase-isomaltase	Homo sapiens	109-126
31585262-4	2019	Among all the tested compounds, 4h has displayed excellent alpha-glucosidase enzyme inhibition activity with IC50 value 12.45 muM to the standard drug acarbose (IC50: 12.68 muM).	Acarbose	151-159	sucrase-isomaltase	Homo sapiens	59-76
31010356-0	2019	Sesquiterpenoids and 2-(2-phenylethyl)chromones respectively acting as alpha-glucosidase and tyrosinase inhibitors from agarwood of an Aquilaria plant.	sesquiterpenoids	0-16	sucrase-isomaltase	Homo sapiens	71-88
31672500-9	2019	alpha-glucosidase inhibitors may be superior to sulfonylureas in reducing the glucose variability in T2DM.	Glucose	78-85	sucrase-isomaltase	Homo sapiens	0-17
31514061-0	2019	Synthesis of benzotriazoles derivatives and their dual potential as alpha-amylase and alpha-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies.	benzotriazole	13-27	sucrase-isomaltase	Homo sapiens	86-103
31514061-4	2019	All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 muM against alpha-glucosidase and alpha-amylase enzymes, respectively.	benzotriazole	4-18	sucrase-isomaltase	Homo sapiens	132-149
31593486-1	2019	Introduction: Alpha-glucosidase inhibitors (AGIs) - oral antihyperglycemic drugs, inhibit upper gastrointestinal enzymes that break down complex carbohydrates into glucose.	Carbohydrates	145-158	sucrase-isomaltase	Homo sapiens	14-31
31593486-1	2019	Introduction: Alpha-glucosidase inhibitors (AGIs) - oral antihyperglycemic drugs, inhibit upper gastrointestinal enzymes that break down complex carbohydrates into glucose.	Glucose	164-171	sucrase-isomaltase	Homo sapiens	14-31
31491512-0	2019	Inhibition of alpha-glucosidase activity and non-enzymatic glycation by tannic acid: Inhibitory activity and molecular mechanism.	Tannins	72-83	sucrase-isomaltase	Homo sapiens	14-31
31491512-2	2019	In this study, multispectroscopic and molecular docking techniques were employed to investigate the inhibition of tannic acid on alpha-glucosidase and glycation.	Tannins	114-125	sucrase-isomaltase	Homo sapiens	129-146
31491512-3	2019	Kinetics analyses revealed that tannic acid had a significant inhibition on alpha-glucosidase (IC50 = 0.35 +- 0.02 muM) in a reversible and mixed competitive manner.	Tannins	32-43	sucrase-isomaltase	Homo sapiens	76-93
31491512-4	2019	The results acquired from fluorescence quenching and ANS-binding fluorescence methods revealed that tannic acid could bind to alpha-glucosidase and reduce the hydrophobic area on the surface of the enzyme.	1-anilino-8-naphthalenesulfonate	53-56	sucrase-isomaltase	Homo sapiens	126-143
31491512-4	2019	The results acquired from fluorescence quenching and ANS-binding fluorescence methods revealed that tannic acid could bind to alpha-glucosidase and reduce the hydrophobic area on the surface of the enzyme.	Tannins	100-111	sucrase-isomaltase	Homo sapiens	126-143
31491512-5	2019	In addition, synchronous fluorescence analysis showed that tannic acid decreased the hydrophobicity of alpha-glucosidase and changed the conformation of the enzyme.	Tannins	59-70	sucrase-isomaltase	Homo sapiens	103-120
31491512-8	2019	Moreover, the results of molecular docking showed the interaction between tannic acid and alpha-glucosidase was mainly driven by hydrogen bond, electrostatic, and hydrophobic interaction.	Tannins	74-85	sucrase-isomaltase	Homo sapiens	90-107
31491512-8	2019	Moreover, the results of molecular docking showed the interaction between tannic acid and alpha-glucosidase was mainly driven by hydrogen bond, electrostatic, and hydrophobic interaction.	Hydrogen	129-137	sucrase-isomaltase	Homo sapiens	90-107
30362362-3	2019	Those 3-arylcoumarin derivatives were screened for antioxidant, alpha-glucosidase inhibitory and advanced glycation end-products (AGEs) formation inhibitory.	3-arylcoumarin	6-20	sucrase-isomaltase	Homo sapiens	64-81
31010356-0	2019	Sesquiterpenoids and 2-(2-phenylethyl)chromones respectively acting as alpha-glucosidase and tyrosinase inhibitors from agarwood of an Aquilaria plant.	2-(2-phenylethyl)chromone	21-47	sucrase-isomaltase	Homo sapiens	71-88
31010356-4	2019	Compounds 5, 7, 8, and 10 showed significant inhibition of alpha-glucosidase with IC50 values ranging between 112.3 +- 4.5 and 524.5 +- 2.7 microM (acarbose, 743.	Acarbose	148-156	sucrase-isomaltase	Homo sapiens	59-76
31654243-5	2019	Additionally, alogliptin has a generally favorable or similar safety profile in comparison to other antidiabetic agents (metformin, thiazolidinediones, sulfonylureas, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, alpha-glucosidase inhibitors, and insulin).	alogliptin	14-24	sucrase-isomaltase	Homo sapiens	253-270
31409467-1	2019	A sensitive nanocomplex probe prepared from fluorescent polydopamine nanoparticles (F-PDA) and cobalt oxyhydroxide (CoOOH) nanosheets was established for the determination of alpha-glucosidase activity.	polydopamine	56-68	sucrase-isomaltase	Homo sapiens	175-192
31409467-1	2019	A sensitive nanocomplex probe prepared from fluorescent polydopamine nanoparticles (F-PDA) and cobalt oxyhydroxide (CoOOH) nanosheets was established for the determination of alpha-glucosidase activity.	HCoO2	95-114	sucrase-isomaltase	Homo sapiens	175-192
31409467-1	2019	A sensitive nanocomplex probe prepared from fluorescent polydopamine nanoparticles (F-PDA) and cobalt oxyhydroxide (CoOOH) nanosheets was established for the determination of alpha-glucosidase activity.	coooh	116-121	sucrase-isomaltase	Homo sapiens	175-192
31409467-3	2019	Subsequently, ascorbic acid was produced from 2-O-alpha-d-glucopyranosyl-l-ascorbic acid which was selectively hydrolyzed by alpha-glucosidase.	Ascorbic Acid	14-27	sucrase-isomaltase	Homo sapiens	125-142
31409467-3	2019	Subsequently, ascorbic acid was produced from 2-O-alpha-d-glucopyranosyl-l-ascorbic acid which was selectively hydrolyzed by alpha-glucosidase.	ascorbic acid 2-O-glucoside	46-88	sucrase-isomaltase	Homo sapiens	125-142
31445191-0	2019	Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro alpha-glucosidase inhibition, kinetic, and docking studies.	biscoumarin-1,2,3-triazole	0-26	sucrase-isomaltase	Homo sapiens	94-111
31445191-1	2019	A novel series of biscoumarin-1,2,3-triazole hybrids 6a-n was prepared and evaluated for alpha-glucosidase inhibitory potential.	biscoumarin-1,2,3-triazole	18-44	sucrase-isomaltase	Homo sapiens	89-106
31445191-2	2019	All fourteen derivatives exhibited excellent alpha-glucosidase inhibitory activity with IC50 values ranging between 13.0 +- 1.5 and 75.5 +- 7.0 microM when compared with the acarbose as standard inhibitor (IC50 = 750.0 +- 12.0 microM).	Acarbose	174-182	sucrase-isomaltase	Homo sapiens	45-62
31244409-0	2019	Inhibitory effects of a sulfated polysaccharide isolated from edible red alga Bangia fusco-purpurea on alpha-amylase and alpha-glucosidase.	Polysaccharides	33-47	sucrase-isomaltase	Homo sapiens	121-138
31969298-0	2019	alpha-Glucosidase inhibitory potential and hemolytic evaluation of newly synthesized 3,4,5-trisubstituted-1,2,4-triazole derivatives.	1,2,4-triazole	85-120	sucrase-isomaltase	Homo sapiens	0-17
31415188-5	2019	Molecular mechanisms involved in the antidiabetic activity of oligosaccharides have been systematically discussed from multiple perspectives, including the improvement of pancreas function, alpha-glucosidase inhibition, the relief of insulin and leptin resistance, anti-inflammatory effects, regulation of gut microbiota and hormones, and the intervention of diabetic risk factors.	Oligosaccharides	62-78	sucrase-isomaltase	Homo sapiens	190-207
31969298-6	2019	Most of the derivatives revealed moderate to good alpha-glucosidase inhibitory activity with reference to acarbose.	Acarbose	106-114	sucrase-isomaltase	Homo sapiens	50-67
32024621-0	2019	Alpha-glucosidase inhibition and molecular docking studies of 1,2-benzothiazine 1,1-dioxide based carbohydrazides.	2-methyl-4-oxo-2H-1,2-benzothiazine-1,1-dioxide	62-91	sucrase-isomaltase	Homo sapiens	0-17
31493868-8	2019	In this study, we investigated the impact of high glucose conditions on expression of sucrase-isomaltase, miR-26a and miR-26b in caco-2 cell line.	Glucose	50-57	sucrase-isomaltase	Homo sapiens	86-104
32024621-0	2019	Alpha-glucosidase inhibition and molecular docking studies of 1,2-benzothiazine 1,1-dioxide based carbohydrazides.	carbohydrazide	98-113	sucrase-isomaltase	Homo sapiens	0-17
32024621-3	2019	A common practice to cure diabetes is the use of alpha-glucosidase inhibitors which help in lowering the blood glucose level.	Glucose	111-118	sucrase-isomaltase	Homo sapiens	49-66
32024621-4	2019	We presented 1,2-benzothiazine 1,1-dioxide derivatives as novel and more potent alpha-glucosidase inhibitors via their in vitro and in silico screenings.	2-methyl-4-oxo-2H-1,2-benzothiazine-1,1-dioxide	13-42	sucrase-isomaltase	Homo sapiens	80-97
31307713-0	2019	Ratiometric fluorescence monitoring of alpha-glucosidase activity based on oxidase-like property of MnO2 nanosheet and its application for inhibitor screening.	manganese dioxide	100-104	sucrase-isomaltase	Homo sapiens	39-56
31720511-0	2019	Synthesis, Structural Studies, and alpha-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1H)-ones Derived from Pyrazol-4-carbaldehyde and Anilines.	3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one	109-141	sucrase-isomaltase	Homo sapiens	35-52
31720511-0	2019	Synthesis, Structural Studies, and alpha-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1H)-ones Derived from Pyrazol-4-carbaldehyde and Anilines.	quinoline-4-carbaldehyde	155-177	sucrase-isomaltase	Homo sapiens	35-52
31720511-8	2019	The entire synthesized compounds showed the potent alpha-glucosidase inhibitory activity compared with acarbose as a standard material.	Acarbose	103-111	sucrase-isomaltase	Homo sapiens	51-68
31307713-3	2019	Herein, we constructed a new MnO2 nanosheet (NS)-based ratiometric fluorescent sensor for alpha-glucosidase activity assay and its inhibitor screening.	manganese dioxide	29-33	sucrase-isomaltase	Homo sapiens	90-107
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	ascorbic acid 2-O-glucoside	5-47	sucrase-isomaltase	Homo sapiens	57-66
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	ascorbic acid 2-O-glucoside	49-52	sucrase-isomaltase	Homo sapiens	57-66
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	mno2 ns	130-137	sucrase-isomaltase	Homo sapiens	57-66
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	mno2 ns	130-137	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	mno2 ns	130-137	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	Manganese(2+)	158-162	sucrase-isomaltase	Homo sapiens	57-66
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	Manganese(2+)	158-162	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	Manganese(2+)	158-162	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	Ascorbic Acid	204-218	sucrase-isomaltase	Homo sapiens	57-66
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	Ascorbic Acid	204-218	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	Ascorbic Acid	204-218	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	ascorbic acid 2-O-glucoside	261-264	sucrase-isomaltase	Homo sapiens	57-66
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	ascorbic acid 2-O-glucoside	261-264	sucrase-isomaltase	Homo sapiens	81-90
31307713-5	2019	When 2-O-alpha-d-glucopyranosyl-l-ascorbic acid (AAG) as alpha-Glu substrate and alpha-Glu were introduced into the above system, MnO2 NS would be reduced to Mn2+ and lose the oxidase-like property since ascorbic acids (AA) were released with the hydrolysis of AAG by alpha-Glu.	ascorbic acid 2-O-glucoside	261-264	sucrase-isomaltase	Homo sapiens	81-90
31307713-8	2019	The fluorescence intensity ratio of DAP to AgNCs linearly decreased with the increasing of alpha-Glu concentrations in the range of 0.2-8 U mL-1, and limit of detection was 0.03 U mL-1.	2,3-diaminophenazine	36-39	sucrase-isomaltase	Homo sapiens	91-100
31307713-8	2019	The fluorescence intensity ratio of DAP to AgNCs linearly decreased with the increasing of alpha-Glu concentrations in the range of 0.2-8 U mL-1, and limit of detection was 0.03 U mL-1.	Silver thiocyanate	43-48	sucrase-isomaltase	Homo sapiens	91-100
31307713-10	2019	As a typical alpha-Glu inhibitor, acarbose was investigated with a low detection limit of 10-8 M. The constructed sensor platform was proven to be sensitive and selective as well as simple, label-free and low-cost, making it promising for the accurate diagnosis of relevant disease and discovery of potential drugs.	Acarbose	34-42	sucrase-isomaltase	Homo sapiens	13-22
31255972-3	2019	Based on our previous studies, four pyrimidine-fused heterocycles (PFH) were selected as they revealed satisfactory inhibitory action against mammalian alpha-glucosidase.	pyrimidine	36-46	sucrase-isomaltase	Homo sapiens	152-169
31649838-0	2019	Synthesis and Inhibitory Effect of Some Indole-Pyrimidine Based Hybrid Heterocycles on alpha-Glucosidase and alpha-Amylase as Potential Hypoglycemic Agents.	indole	40-57	sucrase-isomaltase	Homo sapiens	87-104
31394149-0	2019	Highly selective inhibition of alpha-glucosidase by green synthesised ZnO nanoparticles - In-vitro screening and in-silico docking studies.	Zinc Oxide	70-73	sucrase-isomaltase	Homo sapiens	31-48
31394149-3	2019	Present study investigates the in-vitro antidiabetic activity of ZnO nanoparticles assessing their inhibition efficiency on alpha-glucosidase and alpha-amylase.	Zinc Oxide	65-68	sucrase-isomaltase	Homo sapiens	124-141
31394149-9	2019	Molecular docking models were generated for ZnO association with alpha-glucosidase and possible binding sites were recognized.	Zinc Oxide	44-47	sucrase-isomaltase	Homo sapiens	65-82
31404793-0	2019	Synthesis of novel (R)-4-fluorophenyl-1H-1,2,3-triazoles: A new class of alpha-glucosidase inhibitors.	(r)-4-fluorophenyl-1h-1,2,3-triazoles	19-56	sucrase-isomaltase	Homo sapiens	73-90
31404793-3	2019	alpha-Glucosidase inhibitors are known to reduce the impact of carbohydrates on blood glucose level and prevent the digestion of carbohydrates.	Carbohydrates	63-76	sucrase-isomaltase	Homo sapiens	0-17
31404793-3	2019	alpha-Glucosidase inhibitors are known to reduce the impact of carbohydrates on blood glucose level and prevent the digestion of carbohydrates.	Glucose	86-93	sucrase-isomaltase	Homo sapiens	0-17
31404793-3	2019	alpha-Glucosidase inhibitors are known to reduce the impact of carbohydrates on blood glucose level and prevent the digestion of carbohydrates.	Carbohydrates	129-142	sucrase-isomaltase	Homo sapiens	0-17
31404793-10	2019	This study unravelled a new class of triazole derivatives with alpha-glucosidase inhibitory activity.	Triazoles	37-45	sucrase-isomaltase	Homo sapiens	63-80
31228743-3	2019	Correlation analysis showed that methane production was significantly correlated with the activity of alpha-glucosidase at 0.01 level, and with protease activity, released polysaccharides and VFAs at 0.05 level.	Methane	33-40	sucrase-isomaltase	Homo sapiens	102-119
31255972-3	2019	Based on our previous studies, four pyrimidine-fused heterocycles (PFH) were selected as they revealed satisfactory inhibitory action against mammalian alpha-glucosidase.	N-n-Propyl-N-formylhydrazine	67-70	sucrase-isomaltase	Homo sapiens	152-169
31351380-0	2019	Polyoxometalates: Study of inhibitory kinetics and mechanism against alpha-glucosidase.	polyoxometalate I	0-16	sucrase-isomaltase	Homo sapiens	69-86
31247363-5	2019	The combined use of TB and 0.4 g/g TSS APG achieved the maximal activities of protease (1.8) and alpha-glucosidase (1.9), and the activities of protease and alpha-glucosidase were positively correlated to the dosage of APG.	Terbium	20-22	sucrase-isomaltase	Homo sapiens	97-114
31247363-5	2019	The combined use of TB and 0.4 g/g TSS APG achieved the maximal activities of protease (1.8) and alpha-glucosidase (1.9), and the activities of protease and alpha-glucosidase were positively correlated to the dosage of APG.	Terbium	20-22	sucrase-isomaltase	Homo sapiens	157-174
31351380-2	2019	In this work, the inhibitory effects of polyoxometalates (POMs) affected by three different factors (heteroatom, transition metal substitution element and vanadium substitution number) on alpha-glucosidase were studied.	polyoxometalate I	40-56	sucrase-isomaltase	Homo sapiens	188-205
31351380-2	2019	In this work, the inhibitory effects of polyoxometalates (POMs) affected by three different factors (heteroatom, transition metal substitution element and vanadium substitution number) on alpha-glucosidase were studied.	Metals	47-52	sucrase-isomaltase	Homo sapiens	188-205
31351380-6	2019	More intriguingly, molecular docking simulation suggested that all compounds bind into the active site of alpha-glucosidase by multiple van-der-Waals and hydrogen bond interactions.	Hydrogen	154-162	sucrase-isomaltase	Homo sapiens	106-123
31569830-2	2019	To avoid sugar digestion and postprandial hyperglycemia, it is necessary to inhibit alpha-glucosidase, a digestive enzyme with an important role in carbohydrate digestion.	Carbohydrates	9-14	sucrase-isomaltase	Homo sapiens	84-101
31206698-0	2019	Inhibitory effect of corosolic acid on alpha-glucosidase: kinetics, interaction mechanism, and molecular simulation.	corosolic acid	21-35	sucrase-isomaltase	Homo sapiens	39-56
31206698-4	2019	RESULTS: Corosolic acid significantly inhibited alpha-glucosidase reversibly in an uncompetitive manner and its IC50 value was 1.35 x 10-5 mol L-1 .	corosolic acid	9-23	sucrase-isomaltase	Homo sapiens	48-65
31206698-5	2019	A combination of CRA with myricetin exerted a weak synergy against alpha-glucosidase.	myricetin	26-35	sucrase-isomaltase	Homo sapiens	67-84
31206698-8	2019	CONCLUSIONS: These results may suggest new insights into corosolic acid from food sources as a potential alpha-glucosidase inhibitor that could better control diabetes.	corosolic acid	57-71	sucrase-isomaltase	Homo sapiens	105-122
31569830-2	2019	To avoid sugar digestion and postprandial hyperglycemia, it is necessary to inhibit alpha-glucosidase, a digestive enzyme with an important role in carbohydrate digestion.	Carbohydrates	148-160	sucrase-isomaltase	Homo sapiens	84-101
31378594-1	2019	In searchof the potenttherapeutic agent as an alpha-glucosidase inhibitor, we have synthesized twenty-five analogs (1-25) of quinoline-based Schiff bases as an inhibitoragainst alpha-glucosidase enzyme under positive control acarbose (IC50 = 38.45 +- 0.80 microM).	quinoline-based schiff bases	125-153	sucrase-isomaltase	Homo sapiens	46-63
31461284-0	2019	Comparative Study of Dietary Flavonoids with Different Structures as alpha-Glucosidase Inhibitors and Insulin Sensitizers.	Flavonoids	29-39	sucrase-isomaltase	Homo sapiens	69-86
31461284-1	2019	This work was designed to comparatively investigate 27 dietary flavonoids that act as alpha-glucosidase inhibitors and insulin sensitizers.	Flavonoids	63-73	sucrase-isomaltase	Homo sapiens	86-103
31461284-2	2019	On the basis of the results of an in vitro experiment of alpha-glucosidase inhibition, myricetin (IC50 = 11.63 +- 0.36 muM) possessed the strongest inhibitory effect, followed by apigenin-7-O-glucoside (IC50 = 22.80 +- 0.24 muM) and fisetin (IC50 = 46.39 +- 0.34 muM).	myricetin	87-96	sucrase-isomaltase	Homo sapiens	57-74
31461284-4	2019	The presence of electron-donating and hydrogen bond acceptor groups at position 4" of ring B could improve alpha-glucosidase activity.	Hydrogen	38-46	sucrase-isomaltase	Homo sapiens	107-124
31461284-8	2019	Therefore, apigenin-7-O-glucoside might serve as the most effective alpha-glucosidase inhibitor and insulin sensitizer.	apigetrin	11-33	sucrase-isomaltase	Homo sapiens	68-85
31378594-1	2019	In searchof the potenttherapeutic agent as an alpha-glucosidase inhibitor, we have synthesized twenty-five analogs (1-25) of quinoline-based Schiff bases as an inhibitoragainst alpha-glucosidase enzyme under positive control acarbose (IC50 = 38.45 +- 0.80 microM).	quinoline-based schiff bases	125-153	sucrase-isomaltase	Homo sapiens	177-194
31514404-0	2019	Design, Synthesis, and Activity Evaluation of Novel N-benzyl Deoxynojirimycin Derivatives for Use as alpha-Glucosidase Inhibitors.	N-benzyl-1-deoxynojirimycin	52-77	sucrase-isomaltase	Homo sapiens	101-118
31514404-1	2019	To obtain alpha-glucosidase inhibitors with high activity, 19 NB-DNJDs (N-benzyl-deoxynojirimycin derivatives) were designed and synthesized.	N-benzyl-1-deoxynojirimycin	72-97	sucrase-isomaltase	Homo sapiens	10-27
31514404-6	2019	Molecular docking results showed that three hydrogen bonds were formed between compound 18a and amino acids in the active site of alpha-glucosidase.	Hydrogen	44-52	sucrase-isomaltase	Homo sapiens	130-147
31438605-0	2019	Interaction Mechanism of Flavonoids and alpha-Glucosidase: Experimental and Molecular Modelling Studies.	Flavonoids	25-35	sucrase-isomaltase	Homo sapiens	40-57
31423772-0	2019	Bifunctional Hybrid Enzyme-Catalytic Metal Organic Framework Reactors for alpha-Glucosidase Inhibitor Screening.	Metals	37-42	sucrase-isomaltase	Homo sapiens	74-91
31423772-2	2019	In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with a flower-shaped globular structure was innovatively prepared via self-assembling of alpha-glucosidase (GAA), glucose oxidase (GOx), Cu2+, and 4,4"-bipyridine.	Metals	53-58	sucrase-isomaltase	Homo sapiens	191-208
31423772-2	2019	In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with a flower-shaped globular structure was innovatively prepared via self-assembling of alpha-glucosidase (GAA), glucose oxidase (GOx), Cu2+, and 4,4"-bipyridine.	cupric ion	239-243	sucrase-isomaltase	Homo sapiens	191-208
31423772-2	2019	In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with a flower-shaped globular structure was innovatively prepared via self-assembling of alpha-glucosidase (GAA), glucose oxidase (GOx), Cu2+, and 4,4"-bipyridine.	4,4'-bipyridyl	249-264	sucrase-isomaltase	Homo sapiens	191-208
31254546-0	2019	Phylogenetic analysis reveals key residues in substrate hydrolysis in the isomaltase domain of sucrase-isomaltase and its role in starch digestion.	Starch	130-136	sucrase-isomaltase	Homo sapiens	95-113
31254546-2	2019	Small intestinal breakdown of starch-derived substrates occurs through the mechanisms of small intestinal brush border enzymes, maltase-glucoamylase and sucrase-isomaltase.	Starch	30-36	sucrase-isomaltase	Homo sapiens	153-171
31254546-4	2019	The N-terminal isomaltase domain of sucrase-isomaltase has a unique ability to actively hydrolyze isomaltose substrates in contrast to the sucrase, maltase and glucoamylase enzymes.	Isomaltose	98-108	sucrase-isomaltase	Homo sapiens	36-54
31158750-0	2019	Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: alpha-Glucosidase inhibition and glucose uptake promotion.	xanthone	30-38	sucrase-isomaltase	Homo sapiens	94-111
31158750-0	2019	Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: alpha-Glucosidase inhibition and glucose uptake promotion.	Triazoles	39-47	sucrase-isomaltase	Homo sapiens	94-111
31158750-2	2019	Herein, a series of novel xanthone-triazole derivatives were designed, synthesized, and their alpha-glucosidase inhibitory activities and glucose uptake in HepG2 cells were investigated.	xanthone	26-34	sucrase-isomaltase	Homo sapiens	94-111
31158750-3	2019	Most of the compounds showed better inhibitory activities than the parental compound a (1,3-dihydroxyxanthone, IC50 = 160.8 muM) and 1-deoxynojirimycin (positive control, IC50 = 59.5 muM) towards alpha-glucosidase.	1,3-dihydroxy-xanthone	88-109	sucrase-isomaltase	Homo sapiens	196-213
31158750-3	2019	Most of the compounds showed better inhibitory activities than the parental compound a (1,3-dihydroxyxanthone, IC50 = 160.8 muM) and 1-deoxynojirimycin (positive control, IC50 = 59.5 muM) towards alpha-glucosidase.	1-DEOXYNOJIRIMYCIN	133-151	sucrase-isomaltase	Homo sapiens	196-213
31158750-8	2019	These novel xanthone triazole derivatives exhibited dual therapeutic effects of alpha-glucosidase inhibition and glucose uptake promotion, thus they could be use as antidiabetic agents for developing novel drugs against type 2 diabetes.	xanthone triazole	12-29	sucrase-isomaltase	Homo sapiens	80-97
31454004-0	2019	Correction: A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives.	Carbohydrates	116-128	sucrase-isomaltase	Homo sapiens	167-184
31454004-0	2019	Correction: A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives.	Chalcone	188-196	sucrase-isomaltase	Homo sapiens	167-184
31454004-1	2019	Correction for "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives" by Sonia Rocha, et al., Food Funct., 2019, DOI: 10.1039/c9fo01298b.	Carbohydrates	120-132	sucrase-isomaltase	Homo sapiens	171-188
31454004-1	2019	Correction for "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives" by Sonia Rocha, et al., Food Funct., 2019, DOI: 10.1039/c9fo01298b.	Chalcone	192-200	sucrase-isomaltase	Homo sapiens	171-188
31454004-1	2019	Correction for "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives" by Sonia Rocha, et al., Food Funct., 2019, DOI: 10.1039/c9fo01298b.	c9fo01298b	270-280	sucrase-isomaltase	Homo sapiens	171-188
31414099-0	2019	A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives.	Carbohydrates	104-116	sucrase-isomaltase	Homo sapiens	155-172
31414099-0	2019	A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase by chalcone derivatives.	Chalcone	176-184	sucrase-isomaltase	Homo sapiens	155-172
31414099-1	2019	The inhibition of carbohydrate-hydrolyzing enzymes, alpha-amylase and alpha-glucosidase, is one of the major therapeutic strategies for the treatment of type 2 diabetes mellitus.	Carbohydrates	18-30	sucrase-isomaltase	Homo sapiens	70-87
31414099-3	2019	In the present work, a panel of chalcones bearing hydroxy, methoxy, methyl, nitro, chloro, fluoro and bromo substituents were evaluated against alpha-amylase and alpha-glucosidase activities, most of them for the first time.	Chalcones	32-41	sucrase-isomaltase	Homo sapiens	162-179
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	Chalcones	0-9	sucrase-isomaltase	Homo sapiens	144-161
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	nitro	18-23	sucrase-isomaltase	Homo sapiens	144-161
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	Hydrochloric Acid	35-41	sucrase-isomaltase	Homo sapiens	144-161
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	Chalcone	93-101	sucrase-isomaltase	Homo sapiens	144-161
31438605-1	2019	Flavonoids are known to play a role in hypoglycemia by inhibiting alpha-glucosidase.	Flavonoids	0-10	sucrase-isomaltase	Homo sapiens	66-83
31438605-3	2019	In this study, the alpha-glucosidase inhibitory activities of 15 flavonoids were investigated.	Flavonoids	65-75	sucrase-isomaltase	Homo sapiens	19-36
31112894-2	2019	Since 1990, three alpha-glucosidase inhibitors are known to exist clinically, Acarbose, Voglibose and Miglitol.	Acarbose	78-86	sucrase-isomaltase	Homo sapiens	18-35
31112894-2	2019	Since 1990, three alpha-glucosidase inhibitors are known to exist clinically, Acarbose, Voglibose and Miglitol.	voglibose	88-97	sucrase-isomaltase	Homo sapiens	18-35
31112894-2	2019	Since 1990, three alpha-glucosidase inhibitors are known to exist clinically, Acarbose, Voglibose and Miglitol.	miglitol	102-110	sucrase-isomaltase	Homo sapiens	18-35
31294965-7	2019	Specific activities of both intracellular dehydrogenase (DHA) and extracellular alpha-glucosidase (alpha-Glu) and protease (PRO) enzymes were significantly inhibited (8% to 39%) with an observed NP dose-dependent intracellular reactive oxygen species (ROS) production and shift in biofilm microbial community composition by day 64.	Reactive Oxygen Species	227-250	sucrase-isomaltase	Homo sapiens	80-97
31412567-10	2019	Pe4 polysaccharide demonstrated a good alpha-glucosidase inhibitory activity and antitumor capacity against Hela cells.	pe4 polysaccharide	0-18	sucrase-isomaltase	Homo sapiens	39-56
31293160-3	2019	The interaction characteristics of these five polyphenols with alpha-amylase and alpha-glucosidase were investigated in terms of the inhibition effect, dynamics, fluorescence quenching, and circular dichroism (CD).	Polyphenols	46-57	sucrase-isomaltase	Homo sapiens	81-98
31293160-5	2019	All five polyphenols inhibited the alpha-amylase activity through the noncompetitive approach but inhibited the alpha-glucosidase activity through the competitive approach.	Polyphenols	9-20	sucrase-isomaltase	Homo sapiens	112-129
31293160-7	2019	The interaction of PAs and QU with alpha-glucosidase were recognized as van der Waals forces and H bonding, whereas CA and TA interacted with alpha-glucosidase through the hydrophobic effect.	Proanthocyanidins	19-22	sucrase-isomaltase	Homo sapiens	35-52
31294965-7	2019	Specific activities of both intracellular dehydrogenase (DHA) and extracellular alpha-glucosidase (alpha-Glu) and protease (PRO) enzymes were significantly inhibited (8% to 39%) with an observed NP dose-dependent intracellular reactive oxygen species (ROS) production and shift in biofilm microbial community composition by day 64.	Reactive Oxygen Species	227-250	sucrase-isomaltase	Homo sapiens	99-108
31294965-7	2019	Specific activities of both intracellular dehydrogenase (DHA) and extracellular alpha-glucosidase (alpha-Glu) and protease (PRO) enzymes were significantly inhibited (8% to 39%) with an observed NP dose-dependent intracellular reactive oxygen species (ROS) production and shift in biofilm microbial community composition by day 64.	Reactive Oxygen Species	252-255	sucrase-isomaltase	Homo sapiens	80-97
31294965-7	2019	Specific activities of both intracellular dehydrogenase (DHA) and extracellular alpha-glucosidase (alpha-Glu) and protease (PRO) enzymes were significantly inhibited (8% to 39%) with an observed NP dose-dependent intracellular reactive oxygen species (ROS) production and shift in biofilm microbial community composition by day 64.	Reactive Oxygen Species	252-255	sucrase-isomaltase	Homo sapiens	99-108
31330079-0	2019	A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and alpha-glucosidase inhibition.	Schiff Bases	16-27	sucrase-isomaltase	Homo sapiens	106-123
31330079-0	2019	A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and alpha-glucosidase inhibition.	Triazoles	48-62	sucrase-isomaltase	Homo sapiens	106-123
31330079-1	2019	A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as alpha-glucosidase inhibitors.	Schiff Bases	16-28	sucrase-isomaltase	Homo sapiens	102-119
31330079-1	2019	A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as alpha-glucosidase inhibitors.	1,2,3-triazole 12a-o	37-57	sucrase-isomaltase	Homo sapiens	102-119
31330079-2	2019	All the synthesized compounds showed promising inhibition against alpha-glucosidase and were more potent than the standard drug acarbose.	Acarbose	128-136	sucrase-isomaltase	Homo sapiens	66-83
31330079-3	2019	The kinetic study on the most potent compound 12n showed that this compound acted as a competitive alpha-glucosidase inhibitor.	12-nitroxide stearate	46-49	sucrase-isomaltase	Homo sapiens	99-116
31334505-3	2019	Further study proved that catechin could not only significantly suppress the increase of blood glucose levels, but also inhibit alpha-amylase, alpha-glucosidase and beta-glucosidase strongly with IC50 values of 0.533 mg mL-1, 0.307 mg mL-1 and 0.413 mg mL-1, respectively.	Catechin	26-34	sucrase-isomaltase	Homo sapiens	143-160
31128218-0	2019	Pharmacophore studies of 1, 3, 4-oxadiazole nucleus: Lead compounds as alpha-glucosidase inhibitors.	1,3,4-oxadiazole	25-43	sucrase-isomaltase	Homo sapiens	71-88
31128218-4	2019	Compounds with 1, 3, 4-oxadiazole nucleus have shown preclinical efficacy as alpha-glucosidase inhibitors and as anti-inflammatory agents.	1,3,4-oxadiazole	15-33	sucrase-isomaltase	Homo sapiens	77-94
31317269-0	2019	A novel series of mixed-ligand M(II) complexes containing 2,2"-bipyridyl as potent alpha-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking.	2,2'-Dipyridyl	58-72	sucrase-isomaltase	Homo sapiens	83-100
31336652-5	2019	Enzyme deficiencies have been proposed to result in other food sensitivities including low amine oxidase activity resulting in histamine intolerance and sucrase-isomaltase deficiency resulting in reduced tolerance to sugars and starch.	Starch	228-234	sucrase-isomaltase	Homo sapiens	153-171
31365088-4	2019	Alpha-glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine-topiramate and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk.	Topiramate	139-149	sucrase-isomaltase	Homo sapiens	0-17
31365088-4	2019	Alpha-glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine-topiramate and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk.	Nateglinide	253-264	sucrase-isomaltase	Homo sapiens	0-17
31336868-4	2019	The evaluation of the prospective inhibitors on glucosidases revealed that merely D-gluco-piperidine (miglitol, 41a) and L-ido-azepane (41b) DNJ-derivatives bearing the N-hydroxylethyl group showed inhibition towards alpha-glucosidase with IC50 41 microM and 138 microM, respectively, using DNJ as reference (IC50 134 microM).	d-gluco-piperidine	82-100	sucrase-isomaltase	Homo sapiens	217-234
31336868-4	2019	The evaluation of the prospective inhibitors on glucosidases revealed that merely D-gluco-piperidine (miglitol, 41a) and L-ido-azepane (41b) DNJ-derivatives bearing the N-hydroxylethyl group showed inhibition towards alpha-glucosidase with IC50 41 microM and 138 microM, respectively, using DNJ as reference (IC50 134 microM).	l-ido-azepane	121-134	sucrase-isomaltase	Homo sapiens	217-234
30981359-0	2019	Preliminary characterization, antioxidant and alpha-glucosidase inhibitory activities of polysaccharides from Mallotus furetianus.	Polysaccharides	89-104	sucrase-isomaltase	Homo sapiens	46-63
30954797-0	2019	Integrated multi-spectroscopic and molecular modelling techniques to probe the interaction mechanism between salvianolic acid A and alpha-glucosidase.	salvianolic acid A	109-127	sucrase-isomaltase	Homo sapiens	132-149
30954797-1	2019	alpha-Glucosidase (AG) is an important drug target for the treatment of type 2 diabetes mellitus in humans due to the potential effect of down regulating glucose absorption in patients.	Glucose	154-161	sucrase-isomaltase	Homo sapiens	0-17
31077913-0	2019	Structural modifications of 2,3-indolobetulinic acid: Design and synthesis of highly potent alpha-glucosidase inhibitors.	2,3-indolobetulinic acid	28-52	sucrase-isomaltase	Homo sapiens	92-109
31077913-1	2019	A series of nineteen nitrogen-containing lupane triterpenoids was obtained by modification of C2, C3, C20 and C28 positions of betulonic acid and their alpha-glucosidase inhibiting activity was investigated.	Nitrogen	21-29	sucrase-isomaltase	Homo sapiens	152-169
31077913-1	2019	A series of nineteen nitrogen-containing lupane triterpenoids was obtained by modification of C2, C3, C20 and C28 positions of betulonic acid and their alpha-glucosidase inhibiting activity was investigated.	triterpenoids	48-61	sucrase-isomaltase	Homo sapiens	152-169
30919765-6	2019	Hydrogen bond were important for the binding of all peptides but SASPA and AQSPA had the highest hydrogen bonds interactions with the alpha-glucosidase and alpha-amylase, respectively.	Hydrogen	0-8	sucrase-isomaltase	Homo sapiens	134-151
30919765-6	2019	Hydrogen bond were important for the binding of all peptides but SASPA and AQSPA had the highest hydrogen bonds interactions with the alpha-glucosidase and alpha-amylase, respectively.	Hydrogen	97-105	sucrase-isomaltase	Homo sapiens	134-151
30919765-11	2019	Furthermore, alanine scanning has led to the design of a novel alpha-glucosidase inhibitory peptide, AQSPA, with increased activities.	Alanine	13-20	sucrase-isomaltase	Homo sapiens	63-80
31078411-5	2019	Compounds 4, 5, 6 and 13 exhibited inhibitory activities on alpha-glucosidase with IC50 values of 50.60 +- 1.10, 22.57 +- 0.07, 60.09 +- 1.40, and 80.01 +- 2.66 mug/mL separately, however, all the alpha-glucosidase inhibitory activities were weaker than positive control (acarbose).	Acarbose	272-280	sucrase-isomaltase	Homo sapiens	60-77
31078769-0	2019	Dipyridamole inhibits alpha-amylase/alpha-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies.	Dipyridamole	0-12	sucrase-isomaltase	Homo sapiens	36-53
31078769-4	2019	Substrates of alpha-amylase (alpha-Amy) and alpha-Glucosidase (alpha-Glu), known as key absorbing enzymes, have functional groups (OH groups) similar to DP.	Dipyridamole	153-155	sucrase-isomaltase	Homo sapiens	44-61
30594450-0	2019	alpha-Glucosidase inhibition activity and in silico study of 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one, a synthetic derivative of flavone.	flavone	134-141	sucrase-isomaltase	Homo sapiens	0-17
31168531-5	2019	Moreover, all the polysaccharides showed good alpha-glucosidase inhibitory activities except for MFPu with the lowest molecular weight.	Polysaccharides	18-33	sucrase-isomaltase	Homo sapiens	46-63
31071387-0	2019	Anthraquinone-type inhibitor of alpha-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes.	Anthraquinones	0-13	sucrase-isomaltase	Homo sapiens	32-49
31071387-0	2019	Anthraquinone-type inhibitor of alpha-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes.	Glucose	59-66	sucrase-isomaltase	Homo sapiens	32-49
31071387-3	2019	The data indicate that MTAQ strongly inhibited alpha-glucosidase activity in a concentration-dependent manner, with an IC50 value of 6.49 +- 1.31 muM, and functioned as a reversible competitive inhibitor, with a dissociation constant of 41.88 muM.	mtaq	23-27	sucrase-isomaltase	Homo sapiens	47-64
31242688-0	2019	Spiroindolone Analogues as Potential Hypoglycemic with Dual Inhibitory Activity on alpha-Amylase and alpha-Glucosidase.	spiroindolone	0-13	sucrase-isomaltase	Homo sapiens	101-118
31242688-1	2019	Inhibition of alpha-amylase and alpha-glucosidase by specified synthetic compounds during the digestion of starch helps control post-prandial hyperglycemia and could represent a potential therapy for type II diabetes mellitus.	Starch	107-113	sucrase-isomaltase	Homo sapiens	32-49
31242688-4	2019	The target spiroindolone analogues 5a-r were evaluated for their potential inhibitory activities against the enzymes alpha-amylase and alpha-glucosidase.	5a-r	35-39	sucrase-isomaltase	Homo sapiens	135-152
31242688-6	2019	Among the tested spiroindolone analogues, the cycloadduct 5r was found to be the most active (IC50 = 22.61 +- 0.54 muM and 14.05 +- 1.03 muM) as alpha-amylase and alpha-glucosidase inhibitors, with selectivity indexes of 0.62 and 1.60, respectively.	spiroindolone	17-30	sucrase-isomaltase	Homo sapiens	163-180
30594450-1	2019	A synthetic flavone derivative 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one (BDC) was synthesized by the one pot reaction method and assessed for alpha-glucosidase inhibitory activity.	flavone	12-19	sucrase-isomaltase	Homo sapiens	147-164
30594450-1	2019	A synthetic flavone derivative 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one (BDC) was synthesized by the one pot reaction method and assessed for alpha-glucosidase inhibitory activity.	2-(1,3-benzodioxol-5-yl)-4H-chromen-4-one	31-76	sucrase-isomaltase	Homo sapiens	147-164
30594450-1	2019	A synthetic flavone derivative 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one (BDC) was synthesized by the one pot reaction method and assessed for alpha-glucosidase inhibitory activity.	BDC	78-81	sucrase-isomaltase	Homo sapiens	147-164
30594450-2	2019	The BDC demonstrated dose dependent inhibition of alpha-glucosidase activity.	BDC	4-7	sucrase-isomaltase	Homo sapiens	50-67
30594450-4	2019	The maximum alpha-glucosidase inhibitory activity depicted by BDC 27.6 microM concentration was 22.4 fold over the maximum inhibition observed with acarbose (97.72 +- 0.59% at 669.57 microM), a standard commercial anti-diabetic drug.	BDC	62-65	sucrase-isomaltase	Homo sapiens	12-29
30594450-4	2019	The maximum alpha-glucosidase inhibitory activity depicted by BDC 27.6 microM concentration was 22.4 fold over the maximum inhibition observed with acarbose (97.72 +- 0.59% at 669.57 microM), a standard commercial anti-diabetic drug.	Acarbose	148-156	sucrase-isomaltase	Homo sapiens	12-29
30594450-5	2019	In contrast to acarbose that depicted competitive type inhibition, kinetic studies of alpha-glucosidase inhibition by BDC demonstrated non-competitive inhibition with Km of 0.71 mM-1 and a Vmax of 0.028 mmol/min.	BDC	118-121	sucrase-isomaltase	Homo sapiens	86-103
30594450-6	2019	In silico studies suggest allosteric interaction of BDC with alpha-glucosidase at a minimum binding energy (DeltaG) of -8.64 kcal/mol and Ki of 465.3 nM, whereas, acarbose interacted at the active site of alpha-glucosidase with DeltaG of -9.23 kcal/mol and Ki of 172 nM.	BDC	52-55	sucrase-isomaltase	Homo sapiens	61-78
30594450-6	2019	In silico studies suggest allosteric interaction of BDC with alpha-glucosidase at a minimum binding energy (DeltaG) of -8.64 kcal/mol and Ki of 465.3 nM, whereas, acarbose interacted at the active site of alpha-glucosidase with DeltaG of -9.23 kcal/mol and Ki of 172 nM.	BDC	52-55	sucrase-isomaltase	Homo sapiens	205-222
30594450-6	2019	In silico studies suggest allosteric interaction of BDC with alpha-glucosidase at a minimum binding energy (DeltaG) of -8.64 kcal/mol and Ki of 465.3 nM, whereas, acarbose interacted at the active site of alpha-glucosidase with DeltaG of -9.23 kcal/mol and Ki of 172 nM.	Acarbose	163-171	sucrase-isomaltase	Homo sapiens	61-78
30594450-6	2019	In silico studies suggest allosteric interaction of BDC with alpha-glucosidase at a minimum binding energy (DeltaG) of -8.64 kcal/mol and Ki of 465.3 nM, whereas, acarbose interacted at the active site of alpha-glucosidase with DeltaG of -9.23 kcal/mol and Ki of 172 nM.	Acarbose	163-171	sucrase-isomaltase	Homo sapiens	205-222
30594450-7	2019	Thus BDC significantly inhibited alpha-glucosidase in comparison to acarbose.	BDC	5-8	sucrase-isomaltase	Homo sapiens	33-50
30921647-12	2019	The DCM extract was most active for phosphomolybdenum and alpha-glucosidase inhibition assays.	Methylene Chloride	4-7	sucrase-isomaltase	Homo sapiens	58-75
31195742-6	2019	It is interesting to note that structural changes in capsaicin derivatives had higher impacts on alpha-glucosidase than on alpha-amylase inhibition.	Capsaicin	53-62	sucrase-isomaltase	Homo sapiens	97-114
30604594-1	2019	BACKGROUND: Combination of metformin to reduce the fasting plasma glucose level and an alpha-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect.	Metformin	27-36	sucrase-isomaltase	Homo sapiens	87-104
31195706-2	2019	We have recognized an increased prevalence of sucrase-isomaltase (SI) gene variants in IBS patients, possibly rendering starch- and sucrose-intolerance.	Starch	120-126	sucrase-isomaltase	Homo sapiens	46-64
31195706-2	2019	We have recognized an increased prevalence of sucrase-isomaltase (SI) gene variants in IBS patients, possibly rendering starch- and sucrose-intolerance.	Sucrose	132-139	sucrase-isomaltase	Homo sapiens	46-64
30604594-1	2019	BACKGROUND: Combination of metformin to reduce the fasting plasma glucose level and an alpha-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect.	Glucose	144-151	sucrase-isomaltase	Homo sapiens	87-104
30978605-0	2019	Mechanistic investigation of anthocyanidin derivatives as alpha-glucosidase inhibitors.	Anthocyanins	29-42	sucrase-isomaltase	Homo sapiens	58-75
30978605-1	2019	Eight anthocyanidin derivatives (1-8) were evaluated as potential inhibitors of the catalysis of alpha-glucosidase.	Anthocyanins	6-19	sucrase-isomaltase	Homo sapiens	97-114
30794902-0	2019	Investigation the interaction between procyanidin dimer and alpha-glucosidase: Spectroscopic analyses and molecular docking simulation.	procyanidin	38-49	sucrase-isomaltase	Homo sapiens	60-77
30794902-1	2019	Procyanidins are reported to inhibit alpha-glucosidase, which may be a useful attribute for developing functional foods that control post-prandial blood sugar levels.	Proanthocyanidins	0-12	sucrase-isomaltase	Homo sapiens	37-54
30794902-1	2019	Procyanidins are reported to inhibit alpha-glucosidase, which may be a useful attribute for developing functional foods that control post-prandial blood sugar levels.	Blood Glucose	147-158	sucrase-isomaltase	Homo sapiens	37-54
30794902-2	2019	At present, the nature of the molecular interaction between procyanidins and alpha-glucosidase is poorly understood.	Proanthocyanidins	60-72	sucrase-isomaltase	Homo sapiens	77-94
30794902-3	2019	In this study, spectroscopic analyses and computer simulations were used to investigate the interactions between alpha-glucosidase and B-type procyanidin dimer (BPD).	procyanidin	142-153	sucrase-isomaltase	Homo sapiens	113-130
30794902-8	2019	Molecular docking analysis suggested that BPD formed hydrogen bonds and hydrophobic interactions with alpha-glucosidase when it bound to its active site.	bpd	42-45	sucrase-isomaltase	Homo sapiens	102-119
30794902-9	2019	This research offers new insights into the mechanism of interaction between procyanidins and alpha-glucosidase, which may be useful for the development of functional foods to tackle type 2 diabetes.	Proanthocyanidins	76-88	sucrase-isomaltase	Homo sapiens	93-110
30599411-0	2019	Synthesis of benzothiazole derivatives as a potent alpha-glucosidase inhibitor.	benzothiazole	13-26	sucrase-isomaltase	Homo sapiens	51-68
31107491-0	2019	Selective synthesis of 3-deoxy-5-hydroxy-1-amino-carbasugars as potential alpha-glucosidase inhibitors.	3-deoxy-5-hydroxy-1-amino-carbasugars	23-60	sucrase-isomaltase	Homo sapiens	74-91
30999646-1	2019	A series of symmetrical salicylaldehyde-bishydrazine azo molecules, 5a-5h, have been synthesized, characterized by 1H-NMR and 13C-NMR, and evaluated for their in vitro alpha-glucosidase and alpha-amylase inhibitory activities.	5a-5h	68-73	sucrase-isomaltase	Homo sapiens	168-185
30987350-0	2019	Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and alpha-Glucosidase Inhibitory Activities and In Silico Study.	pyridine-dicarboxamide-cyclohexanone	13-49	sucrase-isomaltase	Homo sapiens	78-95
31019154-1	2019	Elevation of postprandial plasma glucose is correlated with an increase in cardiovascular events, and alpha-glucosidase inhibitors (alphaGIs) are effective at reducing postprandial glucose levels.	Glucose	181-188	sucrase-isomaltase	Homo sapiens	102-119
30859722-0	2019	2-Phenylquinoline-Sugar Hybrids as Photoswitchable alpha-Glucosidase Inhibitors.	2-phenylquinoline-sugar	0-23	sucrase-isomaltase	Homo sapiens	51-68
30859722-1	2019	Purpose-designed 2-phenylquinoline (PQ)-sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an alpha-glucosidase target.	2-phenylquinoline	17-40	sucrase-isomaltase	Homo sapiens	142-159
30859722-1	2019	Purpose-designed 2-phenylquinoline (PQ)-sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an alpha-glucosidase target.	Sugars	40-45	sucrase-isomaltase	Homo sapiens	142-159
30859722-2	2019	The results indicated that PQ-mannose hybrid 2 selectively and effectively photodegraded alpha-glucosidase and significantly inhibited its enzymatic activity upon irradiation with long-wavelength UV light in the absence of any additives under neutral and aqueous conditions.	pq-mannose	27-37	sucrase-isomaltase	Homo sapiens	89-106
30735848-0	2019	Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on alpha-glucosidase.	Water	13-18	sucrase-isomaltase	Homo sapiens	139-156
30735848-0	2019	Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on alpha-glucosidase.	pentacyclic dihydroxyterpene carboxylic acid	27-71	sucrase-isomaltase	Homo sapiens	139-156
30735848-3	2019	Results reveal that some of the derivatives exhibit a better alpha-glucosidase inhibitory activity than that of acarbose in the test conditions of ethanol-water solution and DMSO.	Ethanol	147-154	sucrase-isomaltase	Homo sapiens	61-78
30735848-3	2019	Results reveal that some of the derivatives exhibit a better alpha-glucosidase inhibitory activity than that of acarbose in the test conditions of ethanol-water solution and DMSO.	Water	155-160	sucrase-isomaltase	Homo sapiens	61-78
30735848-3	2019	Results reveal that some of the derivatives exhibit a better alpha-glucosidase inhibitory activity than that of acarbose in the test conditions of ethanol-water solution and DMSO.	Dimethyl Sulfoxide	174-178	sucrase-isomaltase	Homo sapiens	61-78
30735848-5	2019	Unfortunately, all of the derivatives possess lower inhibitory properties of alpha-glucosidase than those of the parent compounds in the measurement system of DMSO solution, even if the derivatives exhibit better water solubility than that of the parent compounds.	Dimethyl Sulfoxide	159-163	sucrase-isomaltase	Homo sapiens	77-94
30735848-5	2019	Unfortunately, all of the derivatives possess lower inhibitory properties of alpha-glucosidase than those of the parent compounds in the measurement system of DMSO solution, even if the derivatives exhibit better water solubility than that of the parent compounds.	Water	213-218	sucrase-isomaltase	Homo sapiens	77-94
31384800-2	2019	alpha-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes.	Acarbose	38-46	sucrase-isomaltase	Homo sapiens	0-17
31384800-2	2019	alpha-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes.	Carbohydrates	72-85	sucrase-isomaltase	Homo sapiens	0-17
31384800-4	2019	We have synthesized 25 tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones hybrids and evaluated their alpha-glucosidase inhibitory activity.	tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4h)	23-92	sucrase-isomaltase	Homo sapiens	126-143
30599411-4	2019	Consequently, alpha glucosidase is one of the potential therapeutic approaches that reduce absorption of glucose and delay carbohydrate digestion hence maintaining blood glucose level.	Glucose	105-112	sucrase-isomaltase	Homo sapiens	14-31
30599411-4	2019	Consequently, alpha glucosidase is one of the potential therapeutic approaches that reduce absorption of glucose and delay carbohydrate digestion hence maintaining blood glucose level.	Carbohydrates	123-135	sucrase-isomaltase	Homo sapiens	14-31
30599411-4	2019	Consequently, alpha glucosidase is one of the potential therapeutic approaches that reduce absorption of glucose and delay carbohydrate digestion hence maintaining blood glucose level.	Glucose	170-177	sucrase-isomaltase	Homo sapiens	14-31
30599411-5	2019	In this regard we have synthesized benzothiazole based oxadiazole in search of potent anti-diabetic agent as alpha-glucosidase Inhibitors.	benzothiazole	35-48	sucrase-isomaltase	Homo sapiens	109-126
30599411-5	2019	In this regard we have synthesized benzothiazole based oxadiazole in search of potent anti-diabetic agent as alpha-glucosidase Inhibitors.	Oxadiazoles	55-65	sucrase-isomaltase	Homo sapiens	109-126
30599411-6	2019	Benzothiazole based oxadiazole derivatives 1-23 have been synthesized, characterized by 1HNMR, 13CNMR, and MS and evaluated for alpha-glucosidase Inhibition.	benzothiazole	0-13	sucrase-isomaltase	Homo sapiens	128-145
30599411-6	2019	Benzothiazole based oxadiazole derivatives 1-23 have been synthesized, characterized by 1HNMR, 13CNMR, and MS and evaluated for alpha-glucosidase Inhibition.	Oxadiazoles	20-30	sucrase-isomaltase	Homo sapiens	128-145
31148890-3	2019	Methods and Material: In vitro alpha-amylase and alpha-glucosidase inhibitory effect of ajwain oil was carried out by the method of Bernfeld and Shibano et al.	ajwain oil	88-98	sucrase-isomaltase	Homo sapiens	49-66
30776576-0	2019	Polyoxomolybdates as alpha-glucosidase inhibitors: Kinetic and molecular modeling studies.	polyoxomolybdates	0-17	sucrase-isomaltase	Homo sapiens	21-38
30776576-1	2019	Noninsulin dependent diabetes mellitus is a serious global disease that is treated by inhibiting alpha-glucosidase to reduce the glucose content in the blood.	Glucose	129-136	sucrase-isomaltase	Homo sapiens	97-114
30776576-6	2019	Na6PMo11FeO40 inhibited alpha-glucosidase in a reversible noncompetitive manner with KI and KIS of 0.312 mM and 0.412 mM, respectively.	na6pmo11feo40	0-13	sucrase-isomaltase	Homo sapiens	24-41
30776576-8	2019	This work presents a promising new perspective for designing effective alpha-glucosidase inhibitors and further demonstrates the enormous potential of polyoxomolybdates as enzyme inhibitors.	polyoxomolybdates	151-168	sucrase-isomaltase	Homo sapiens	71-88
31148890-10	2019	The maximum in vitro alpha - glucosidase inhibitory activity was found to be 89 +- 0.72 % and 91.67 +- 1.09% at 4microL/ml for ajwain oil and acarbose.	ajwain oil	127-137	sucrase-isomaltase	Homo sapiens	21-40
31148890-10	2019	The maximum in vitro alpha - glucosidase inhibitory activity was found to be 89 +- 0.72 % and 91.67 +- 1.09% at 4microL/ml for ajwain oil and acarbose.	Acarbose	142-150	sucrase-isomaltase	Homo sapiens	21-40
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	epigallocatechin gallate	89-93	sucrase-isomaltase	Homo sapiens	98-115
30625522-0	2019	Enzyme immobilized on polyamidoamine-coated magnetic microspheres for alpha-glucosidase inhibitors screening from Radix Paeoniae Rubra extracts accompanied with molecular modeling.	Poly(amidoamine)	22-36	sucrase-isomaltase	Homo sapiens	70-87
30625522-1	2019	In this study, a method for direct screening and identification of alpha-glucosidase inhibitors (AGIs) from extracts of natural products was established based on polyamidoamine (PAMAM) coated magnetic microspheres.	Poly(amidoamine)	162-176	sucrase-isomaltase	Homo sapiens	67-84
30625522-1	2019	In this study, a method for direct screening and identification of alpha-glucosidase inhibitors (AGIs) from extracts of natural products was established based on polyamidoamine (PAMAM) coated magnetic microspheres.	Poly(amidoamine)	178-183	sucrase-isomaltase	Homo sapiens	67-84
30625522-2	2019	A facile route to synthesize the magnetic PAMAM was employed and alpha-glucosidase was successfully covalently attached to its surface through cross linking of glutaraldehyde.	Poly(amidoamine)	42-47	sucrase-isomaltase	Homo sapiens	65-82
30625522-2	2019	A facile route to synthesize the magnetic PAMAM was employed and alpha-glucosidase was successfully covalently attached to its surface through cross linking of glutaraldehyde.	Glutaral	160-174	sucrase-isomaltase	Homo sapiens	65-82
30625522-6	2019	Moreover, the alpha-glucosidase on the surface of PAMAM coating maintained high storage stability and remarkable reusability.	Poly(amidoamine)	50-55	sucrase-isomaltase	Homo sapiens	14-31
30625522-7	2019	Taking advantage of specific interaction of the alpha-glucosidase with AGIs, the materials could selectively capture a known AGI (+)-catechin under the interference of an inactive compound salicylic acid, with a binding capacity as high as 15.4%.	agi (+)-catechin	125-141	sucrase-isomaltase	Homo sapiens	48-65
30625522-7	2019	Taking advantage of specific interaction of the alpha-glucosidase with AGIs, the materials could selectively capture a known AGI (+)-catechin under the interference of an inactive compound salicylic acid, with a binding capacity as high as 15.4%.	Salicylic Acid	189-203	sucrase-isomaltase	Homo sapiens	48-65
30625522-8	2019	Additionally, using the Fe3O4 @PAMAM@alpha-Glu microspheres in the inhibition assay, the enzymatic reaction could be stopped by magnetic separation instead of the traditional addition of Na2CO3 solution, which not only eliminated the disturbance of termination reagent to the results, but also reused the immobilized alpha-glucosidase.	ferryl iron	24-29	sucrase-isomaltase	Homo sapiens	317-334
30625522-8	2019	Additionally, using the Fe3O4 @PAMAM@alpha-Glu microspheres in the inhibition assay, the enzymatic reaction could be stopped by magnetic separation instead of the traditional addition of Na2CO3 solution, which not only eliminated the disturbance of termination reagent to the results, but also reused the immobilized alpha-glucosidase.	Poly(amidoamine)	31-36	sucrase-isomaltase	Homo sapiens	317-334
30625522-8	2019	Additionally, using the Fe3O4 @PAMAM@alpha-Glu microspheres in the inhibition assay, the enzymatic reaction could be stopped by magnetic separation instead of the traditional addition of Na2CO3 solution, which not only eliminated the disturbance of termination reagent to the results, but also reused the immobilized alpha-glucosidase.	alpha-glu	37-46	sucrase-isomaltase	Homo sapiens	317-334
30625522-8	2019	Additionally, using the Fe3O4 @PAMAM@alpha-Glu microspheres in the inhibition assay, the enzymatic reaction could be stopped by magnetic separation instead of the traditional addition of Na2CO3 solution, which not only eliminated the disturbance of termination reagent to the results, but also reused the immobilized alpha-glucosidase.	sodium carbonate	187-193	sucrase-isomaltase	Homo sapiens	317-334
30976294-4	2019	Methods: As an important enzyme for glucose metabolism, alpha-glucosidase was immobilized on polycaprolactone-chitosan-modified paper to prepare the microdevice with unique microfluid structure generated by 3D printing technology, which can be easily applied to screen active compounds in herbal extracts.	Glucose	36-43	sucrase-isomaltase	Homo sapiens	56-73
30976294-4	2019	Methods: As an important enzyme for glucose metabolism, alpha-glucosidase was immobilized on polycaprolactone-chitosan-modified paper to prepare the microdevice with unique microfluid structure generated by 3D printing technology, which can be easily applied to screen active compounds in herbal extracts.	polycaprolactone	93-109	sucrase-isomaltase	Homo sapiens	56-73
30976294-7	2019	The paper microarray with alpha-glucosidase immobilized was used to screen active compounds in the water extracts of mulberry leaves and lotus leaves.	Water	99-104	sucrase-isomaltase	Homo sapiens	26-43
30976294-10	2019	Four compounds including chlorogenic acid, quercetin-3-O-glucuronide, isoquercetin, and quercetin were identified as alpha-glucosidase inhibitors.	Chlorogenic Acid	25-41	sucrase-isomaltase	Homo sapiens	117-134
30976294-10	2019	Four compounds including chlorogenic acid, quercetin-3-O-glucuronide, isoquercetin, and quercetin were identified as alpha-glucosidase inhibitors.	quercetin 3-O-glucuronide	43-68	sucrase-isomaltase	Homo sapiens	117-134
30976294-10	2019	Four compounds including chlorogenic acid, quercetin-3-O-glucuronide, isoquercetin, and quercetin were identified as alpha-glucosidase inhibitors.	isoquercitrin	70-82	sucrase-isomaltase	Homo sapiens	117-134
30976294-10	2019	Four compounds including chlorogenic acid, quercetin-3-O-glucuronide, isoquercetin, and quercetin were identified as alpha-glucosidase inhibitors.	Quercetin	43-52	sucrase-isomaltase	Homo sapiens	117-134
30917543-4	2019	We found that resveratrol exhibits a more potent inhibitory capacity towards alpha-glucosidase than pancreatic lipase activity.	Resveratrol	14-25	sucrase-isomaltase	Homo sapiens	77-94
30529552-0	2019	Inhibitory effect of epigallocatechin-3-O-gallate on alpha-glucosidase and its hypoglycemic effect via targeting PI3K/AKT signaling pathway in L6 skeletal muscle cells.	epigallocatechin gallate	21-49	sucrase-isomaltase	Homo sapiens	53-70
30529552-2	2019	In the present study, the interaction between EGCG and alpha-glucosidase was investigated through kinetics analysis, fluorescence spectra, Fourier transform infrared (FT-IR) spectra and molecular docking studies.	epigallocatechin gallate	46-50	sucrase-isomaltase	Homo sapiens	55-72
30529552-4	2019	The results showed that the alpha-glucosidase inhibitory activity of EGCG (IC50 = 19.5 +- 0.3 muM) was higher than that acarbose (IC50 = 278.7 +- 1.1 muM).	epigallocatechin gallate	69-73	sucrase-isomaltase	Homo sapiens	28-45
30529552-5	2019	EGCG inhibited alpha-glucosidase in a reversible and non-competitive manner.	epigallocatechin gallate	0-4	sucrase-isomaltase	Homo sapiens	15-32
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	epigallocatechin gallate	0-4	sucrase-isomaltase	Homo sapiens	34-51
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	epigallocatechin gallate	0-4	sucrase-isomaltase	Homo sapiens	98-115
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	epigallocatechin gallate	89-93	sucrase-isomaltase	Homo sapiens	34-51
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	Hydrogen	127-135	sucrase-isomaltase	Homo sapiens	34-51
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	Hydrogen	127-135	sucrase-isomaltase	Homo sapiens	98-115
30529552-7	2019	Microenvironment and the secondary structure of alpha-glucosidase were highly influenced by EGCG.	epigallocatechin gallate	92-96	sucrase-isomaltase	Homo sapiens	48-65
30529552-8	2019	Molecular docking results indicated that the binding sites on alpha-glucosidase for EGCG were close to the active site pocket of the enzyme.	epigallocatechin gallate	84-88	sucrase-isomaltase	Homo sapiens	62-79
30537502-0	2019	Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of alpha-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion.	ascophyllan hs	22-36	sucrase-isomaltase	Homo sapiens	97-114
30537502-1	2019	A sulfated polysaccharide ascophyllan inhibited alpha-glucosidase in a concentration dependent manner, and &gt;90% activity was inhibited at 1.0 mg/mL.	Polysaccharides	11-25	sucrase-isomaltase	Homo sapiens	48-65
30537502-1	2019	A sulfated polysaccharide ascophyllan inhibited alpha-glucosidase in a concentration dependent manner, and &gt;90% activity was inhibited at 1.0 mg/mL.	ascophyllin	26-37	sucrase-isomaltase	Homo sapiens	48-65
30537502-4	2019	Ascophyllan HS, a commercially available ascophyllan preparation showed even higher inhibitory effect on alpha-glucosidase than ascophyllan.	ascophyllan hs	0-14	sucrase-isomaltase	Homo sapiens	105-122
30537502-4	2019	Ascophyllan HS, a commercially available ascophyllan preparation showed even higher inhibitory effect on alpha-glucosidase than ascophyllan.	ascophyllin	41-52	sucrase-isomaltase	Homo sapiens	105-122
30537502-8	2019	This is the first report indicating that ascophyllan can induce the secretion of GLP-1 from human intestinal cell line (NCI-H716), besides the potent inhibitory effect on alpha-glucosidase.	ascophyllin	41-52	sucrase-isomaltase	Homo sapiens	171-188
30530108-0	2019	Xanthenone-based hydrazones as potent alpha-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies.	xanthenone-based hydrazones	0-27	sucrase-isomaltase	Homo sapiens	38-55
30530108-3	2019	The compounds unveiled a varying degree of alpha-glucosidase inhibitory activity when compared with standard acarbose (IC50 = 375.38 +- 0.12 microM).	Acarbose	109-117	sucrase-isomaltase	Homo sapiens	43-60
30530108-1	2019	Xanthenone based hydrazone derivatives (5a-n) have been synthesized as potential alpha-glucosidase inhibitors.	xanthone	0-10	sucrase-isomaltase	Homo sapiens	81-98
30500522-0	2019	The first target specific, highly diastereoselective synthesis, design and characterization of pyranoquinolinyl acrylic acid diastereomers as potential alpha-glucosidase inhibitors.	pyranoquinolinyl acrylic acid	95-124	sucrase-isomaltase	Homo sapiens	152-169
30500522-1	2019	In the present investigation we report the first target specific, highly diastereoselective synthesis of new class of pyranoquinolinyl/furoquinolinyl-acrylic acid diastereomers and evaluation of their invitro alpha-glucosidase inhibitory activity.	pyranoquinolinyl	118-134	sucrase-isomaltase	Homo sapiens	209-226
30500522-1	2019	In the present investigation we report the first target specific, highly diastereoselective synthesis of new class of pyranoquinolinyl/furoquinolinyl-acrylic acid diastereomers and evaluation of their invitro alpha-glucosidase inhibitory activity.	furoquinolinyl-acrylic acid	135-162	sucrase-isomaltase	Homo sapiens	209-226
30500522-4	2019	It was found that among a set of 4 diastereomeric products obtained, exodiasteromers of pyranoquinolinyl acrylic acid adducts exhibited relatively high alpha-glucosidase inhibitory activity.	pyranoquinolinyl acrylic acid	88-117	sucrase-isomaltase	Homo sapiens	152-169
30530108-1	2019	Xanthenone based hydrazone derivatives (5a-n) have been synthesized as potential alpha-glucosidase inhibitors.	Hydrazones	17-26	sucrase-isomaltase	Homo sapiens	81-98
30500522-7	2019	It was also found that unsubstituted compound (11a) or compounds with chlorine or methoxy substituent (11c, 11d, 12d) showed potential alpha-glucosidase inhibitory activity.	Chlorine	70-78	sucrase-isomaltase	Homo sapiens	135-152
30530108-1	2019	Xanthenone based hydrazone derivatives (5a-n) have been synthesized as potential alpha-glucosidase inhibitors.	5a-n	40-44	sucrase-isomaltase	Homo sapiens	81-98
30668111-2	2019	In this study, a crude ethyl acetate extract of Machilus litseifolia was fractionated by solid-phase extraction using C18 cartridges to give a fraction enriched in alpha-glucosidase inhibitors.	ethyl acetate	23-36	sucrase-isomaltase	Homo sapiens	164-181
30712980-0	2019	Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting alpha-glucosidase on cell membranes.	1-Deoxynojirimycin	9-25	sucrase-isomaltase	Homo sapiens	91-108
30712980-2	2019	1-Deoxynojirimycin (DNJ) can be actively captured by cells which express the surface membrane protein alpha-glucosidase.	1-Deoxynojirimycin	0-18	sucrase-isomaltase	Homo sapiens	102-119
30712980-2	2019	1-Deoxynojirimycin (DNJ) can be actively captured by cells which express the surface membrane protein alpha-glucosidase.	1-Deoxynojirimycin	20-23	sucrase-isomaltase	Homo sapiens	102-119
30712980-4	2019	Docking simulations revealed that the inhibitors acarbose and miglitol and the inhibitor portion of the probes bind at the same position in the pocket of alpha-glucosidase (human-derived PDB: 3TON).	Acarbose	49-57	sucrase-isomaltase	Homo sapiens	154-171
30503787-0	2019	Inhibitory effect of phloroglucinol on alpha-glucosidase: Kinetics and molecular dynamics simulation integration study.	Phloroglucinol	21-35	sucrase-isomaltase	Homo sapiens	39-56
30503787-2	2019	In this study, we conducted a phloroglucinol-induced inhibition kinetics assay and performed computational molecular dynamics (MD) simulations to assess binding manner in alpha-glucosidase.	Phloroglucinol	30-44	sucrase-isomaltase	Homo sapiens	171-188
30503787-3	2019	The results showed that phloroglucinol reversibly inhibited alpha-glucosidase in a dose-dependent but non-competitive manner (Ki=2.07+-0.16mM).	Phloroglucinol	24-38	sucrase-isomaltase	Homo sapiens	60-77
30668111-6	2019	IC50 values of isolated compounds toward alpha-glucosidase range from 5.9 to 35.3 muM, which is 8 to 91 times lower than the IC50 value of 266 muM measured for the reference compound acarbose.	Acarbose	183-191	sucrase-isomaltase	Homo sapiens	41-58
30504654-1	2019	In this study, a series of salicylic acid derivatives were designed and synthesized as novel non-saccharide alpha-glucosidase inhibitors.	Salicylic Acid	27-41	sucrase-isomaltase	Homo sapiens	108-125
30529825-2	2019	The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease, alpha-glucosidase and alpha-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders.	Water	4-9	sucrase-isomaltase	Homo sapiens	284-301
30529825-9	2019	A favorable binding energy of tubuloside A to tyrosinase was calculated, and indicated this compound as a possible competitive inhibitor of alpha-glucosidase and tyrosinase.	Tubuloside A	30-42	sucrase-isomaltase	Homo sapiens	140-157
30504654-2	2019	Biological evaluation indicated that when compared to acarbose, compounds T9, T10, and T32 exhibited a higher potency of alpha-glucosidase inhibitory activity with IC50 values of 0.15 +- 0.01, 0.086 +- 0.01 and 0.32 +- 0.02 mM, respectively.	Acarbose	54-62	sucrase-isomaltase	Homo sapiens	121-138
30504654-0	2019	A New Series of Salicylic Acid Derivatives as Non-saccharide alpha-Glucosidase Inhibitors and Antioxidants.	Salicylic Acid	16-30	sucrase-isomaltase	Homo sapiens	61-78
30504654-3	2019	Evaluation of the inhibition kinetics indicated that T9, T10, T32, and acarbose interacted with alpha-glucosidase in a mixed non-competitive inhibitory manner.	Acarbose	71-79	sucrase-isomaltase	Homo sapiens	96-113
30504654-5	2019	The docking results showed that hydrogen bonds were generated between the test compounds and alpha-glucosidase.	Hydrogen	32-40	sucrase-isomaltase	Homo sapiens	93-110
30504654-7	2019	In brief, the salicylic acid derivatives identified in this study were promising candidates for development as novel non-saccharide alpha-glucosidase inhibitors.	Salicylic Acid	14-28	sucrase-isomaltase	Homo sapiens	132-149
30227201-0	2019	Inhibitory kinetics and mechanism of rifampicin on alpha-glucosidase: Insights from spectroscopic and molecular docking analyses.	Rifampin	37-47	sucrase-isomaltase	Homo sapiens	51-68
30227201-2	2019	In this study, the inhibitory effect and mechanism of rifampicin on alpha-glucosidase were investigated by multispectroscopic methods along with molecular docking technique.	Rifampin	54-64	sucrase-isomaltase	Homo sapiens	68-85
30227201-3	2019	The results showed that rifampicin inhibited alpha-glucosidase activity prominently (IC50 = 135 +- 1.2 muM) in a reversible and competitive-type manner.	Rifampin	24-34	sucrase-isomaltase	Homo sapiens	45-62
30401648-2	2019	For alpha-Glu immobilization, glutaraldehyde (GA) was used as a coupling agent.	Glutaral	30-44	sucrase-isomaltase	Homo sapiens	4-13
30227201-4	2019	The fluorescence intensity of alpha-glucosidase was quenched by rifampicin through forming rifampicin-alpha-glucosidase complex in a static procedure.	Rifampin	64-74	sucrase-isomaltase	Homo sapiens	30-47
30401648-2	2019	For alpha-Glu immobilization, glutaraldehyde (GA) was used as a coupling agent.	Glutaral	46-48	sucrase-isomaltase	Homo sapiens	4-13
30227201-4	2019	The fluorescence intensity of alpha-glucosidase was quenched by rifampicin through forming rifampicin-alpha-glucosidase complex in a static procedure.	Rifampin	64-74	sucrase-isomaltase	Homo sapiens	102-119
30227201-5	2019	And the formation of the rifampicin-alpha-glucosidase complex was driven spontaneously by hydrophobic forces and hydrogen bonds.	Hydrogen	113-121	sucrase-isomaltase	Homo sapiens	36-53
30227201-6	2019	The results obtained from molecular docking further indicated that hydrophobic forces were formed between rifampicin and amino acid residues Phe 173, Pro151, and hydrogen bonds were generated by the interactions of rifampicin with residues Ser 180, Asn 414, Gly160, and Gly161 of alpha-glucosidase.	Hydrogen	162-170	sucrase-isomaltase	Homo sapiens	280-297
30227201-7	2019	Moreover, it was found that the binding of rifampicin to alpha-glucosidase could alter the conformation of the enzyme to make it steady, and the binding distance was estimated to be 1.02 nm.	Rifampin	43-53	sucrase-isomaltase	Homo sapiens	57-74
29421954-1	2019	Human alpha-glucosidase is an enzyme involved in the catalytic cleavage of the glucoside bond and involved in numerous functionalities of the organism, as well as in the insurgence of diabetes mellitus 2 and obesity.	Glucosides	79-88	sucrase-isomaltase	Homo sapiens	6-23
31333110-3	2019	Alpha-glucosidase is a family of enzyme originated from the pancreas which plays role in anabolism of 80-90% of carbohydrate consumed into glucose.	Carbohydrates	112-124	sucrase-isomaltase	Homo sapiens	0-17
30401648-4	2019	In addition, the CFP/CS-immobilized alpha-Glu can be directly taken out from the reaction mixture after an enzymatic reaction.	Cesium	21-23	sucrase-isomaltase	Homo sapiens	36-45
30401648-6	2019	Combined with capillary electrophoresis (CE), the CFP/CS-immobilized alpha-Glu was then used for enzyme kinetic and inhibition study.	Cesium	54-56	sucrase-isomaltase	Homo sapiens	69-78
30401648-7	2019	The CFP/CS-immobilized alpha-Glu exhibited enhanced pH and temperature tolerance.	Cesium	8-10	sucrase-isomaltase	Homo sapiens	23-32
30401648-8	2019	In addition, the performance of the CFP/CS-immobilized alpha-Glu was studied.	Cesium	40-42	sucrase-isomaltase	Homo sapiens	55-64
30590468-5	2019	Acarbose, an alpha-glucosidase inhibitor, is a pseudo-saccharide that has an overall resemblance to a glucose-based oligosaccharide and thus may be viewed as a structural analog.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
30590468-5	2019	Acarbose, an alpha-glucosidase inhibitor, is a pseudo-saccharide that has an overall resemblance to a glucose-based oligosaccharide and thus may be viewed as a structural analog.	pseudo-saccharide	47-64	sucrase-isomaltase	Homo sapiens	13-30
30469042-4	2019	This review highlights the recent developments of azepane-based compounds in a wide range of therapeutic applications, such as anti-cancer, anti-tubercular, anti-Alzheimer"s disease, and antimicrobial agents, as well as, histamine H3 receptor inhibitors, alpha-glucosidase inhibitors, anticonvulsant drugs and other miscellaneous applications.	hexahydroazepine	50-57	sucrase-isomaltase	Homo sapiens	255-272
30098884-9	2019	This study elucidated the detailed interaction mechanism of DNJ with glucoamylase, which will be helpful for pharmaceutical companies to design new alpha-glucosidase inhibitor drugs based on polyhydroxylated alkaloids compound like DNJ.	1-Deoxynojirimycin	60-63	sucrase-isomaltase	Homo sapiens	148-165
31333110-3	2019	Alpha-glucosidase is a family of enzyme originated from the pancreas which plays role in anabolism of 80-90% of carbohydrate consumed into glucose.	Glucose	139-146	sucrase-isomaltase	Homo sapiens	0-17
30760191-0	2019	Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes.	uranyl(vi) hydrazide	66-86	sucrase-isomaltase	Homo sapiens	11-28
30484413-0	2019	Plant-derived Glycosides with alpha-Glucosidase Inhibitory Activity: Current Standing and Future Prospects.	Glycosides	14-24	sucrase-isomaltase	Homo sapiens	30-47
30484413-1	2019	BACKGROUND: The alpha-glucosidase (EC 3.2.1.20), a calcium-containing intestinal enzyme which is positioned in the cells which cover the intestinal microvilli brush border.	Calcium	51-58	sucrase-isomaltase	Homo sapiens	16-33
30484413-2	2019	The carbohydrates require metabolism by alpha-glucosidase before being absorbed into the small intestine, and as a result, this enzyme represents a significant drug target for the effective management of diabetes.	Carbohydrates	4-17	sucrase-isomaltase	Homo sapiens	40-57
30484413-6	2019	Herein in this review, we have focused on the preclinical studies on various glycosides with in vitro alpha-glucosidase inhibitory activity.	Glycosides	77-87	sucrase-isomaltase	Homo sapiens	102-119
30207240-0	2019	Synthesis, Molecular Modeling and Biological Evaluation of 5-arylidene-N,N-diethylthiobarbiturates as Potential alpha-glucosidase Inhibitors.	5-arylidene-n,n-diethylthiobarbiturates	59-98	sucrase-isomaltase	Homo sapiens	112-129
29331942-0	2019	Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition.	Carbohydrates	65-78	sucrase-isomaltase	Homo sapiens	0-18
30207240-5	2019	OBJECTIVE: Synthesis of 5-arylidene-N,N-diethylthiobarbiturates, biological evaluation as potential alpha-glucosidase inhibitors and molecular modeling.	5-arylidene-n,n-diethylthiobarbiturates	24-63	sucrase-isomaltase	Homo sapiens	100-117
30760191-5	2019	Metal complexes along with their respective ligands were further screened for their antioxidant (DPPH, superoxide and nitric oxide free radicals) properties and enzyme inhibition (alpha-glucosidase) activities.	Metals	0-5	sucrase-isomaltase	Homo sapiens	180-197
30592787-1	2018	BACKGROUND: Alpha-glucosidase inhibitors (AGI) reduce blood glucose levels and may thus prevent or delay type 2 diabetes mellitus (T2DM) and its associated complications in people at risk of developing of T2DM.	Blood Glucose	54-67	sucrase-isomaltase	Homo sapiens	12-29
30251608-1	2019	BACKGROUND: Postprandial hyperglycemia can be reduced by inhibiting major carbohydrate hydrolyzing enzymes, such as alpha-glucosidase and alpha-amylase which is an effective approach in both preventing and treating diabetes.	Carbohydrates	74-86	sucrase-isomaltase	Homo sapiens	116-133
30251608-2	2019	OBJECTIVE: The aim of this study was to synthesize a series of 2,4-dichloro-5-[(N-aryl/alkyl)sulfamoyl] benzoic acid derivatives and evaluate alpha-glucosidase and alpha-amylase inhibitory activity along with molecular docking and in silico ADMET property analysis.	2,4-dichloro-5-[(	63-80	sucrase-isomaltase	Homo sapiens	142-159
30251608-6	2019	RESULTS: Compound 3c (2,4-dichloro-5-[(2-nitrophenyl)sulfamoyl]benzoic acid) was found to be highly active having 3 fold inhibitory potential against alpha-amylase and 5 times inhibitory activity against alpha-glucosidase in comparison to standard drug acarbose.	2,4-dichloro-5-[(2-nitrophenyl)sulfamoyl]benzoic acid	22-75	sucrase-isomaltase	Homo sapiens	204-221
30251608-7	2019	CONCLUSION: Most of the synthesized compounds were highly potent or equipotent to standard drug acarbose for inhibitory potential against alpha-glucosidase and alpha-amylase enzyme and hence this may indicate their antidiabetic activity.	Acarbose	96-104	sucrase-isomaltase	Homo sapiens	138-155
30200805-0	2018	A green chemical oligomerization of phloroglucinol induced by plasma as novel alpha-glucosidase inhibitors.	Phloroglucinol	36-50	sucrase-isomaltase	Homo sapiens	78-95
30394469-0	2018	Pelargonidin-3-O-rutinoside as a novel alpha-glucosidase inhibitor for improving postprandial hyperglycemia.	pelargonidin 3-O-rutinoside betaine	0-27	sucrase-isomaltase	Homo sapiens	39-56
30394469-3	2018	Structural determinants for inhibition of alpha-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.	pg3r	63-67	sucrase-isomaltase	Homo sapiens	42-59
30394469-3	2018	Structural determinants for inhibition of alpha-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.	Anthocyanins	91-103	sucrase-isomaltase	Homo sapiens	42-59
30470596-0	2018	Corrigendum to "Design, synthesis and in vitro study of densely functionalized oxindoles as potent alpha-glucosidase inhibitors" [Bioorg.	Oxindoles	79-88	sucrase-isomaltase	Homo sapiens	99-116
30096627-1	2018	Treatment of type 2 diabetes is achieved through the inhibition of carbohydrate hydrolyzing enzymes such as alpha-glucosidase and alpha-amylase.	Carbohydrates	67-79	sucrase-isomaltase	Homo sapiens	108-125
30118991-0	2018	Synthesis of 1H-1,2,3-triazole derivatives as new alpha-glucosidase inhibitors and their molecular docking studies.	Triazoles	13-30	sucrase-isomaltase	Homo sapiens	50-67
30096627-7	2018	Hydrogen bond interactions were critical for the binding of both peptides to the alpha-glucosidase and alpha-amylase.	Hydrogen	0-8	sucrase-isomaltase	Homo sapiens	81-98
30371346-3	2018	It is caused by compound heterozygous or homozygous mutations in the GAA gene, which encodes for the lysosomal enzyme alpha-glucosidase, required for the degrading of lysosomal glycogen.	Glycogen	177-185	sucrase-isomaltase	Homo sapiens	118-135
30166092-1	2018	BACKGROUND: Pompe disease (PD) is a rare condition caused by mutations in gene encoding for the enzyme alpha-glucosidase, resulting in an abnormal intracellular accumulation of glycogen.	Glycogen	177-185	sucrase-isomaltase	Homo sapiens	103-120
30363678-1	2018	Pompe disease is an autosomal recessive disorder characterized by deficiency of alpha-glucosidase, a lysosomal enzyme, which can lead to glycogen accumulation in skeletal muscle, heart, and nervous system.	Glycogen	137-145	sucrase-isomaltase	Homo sapiens	80-97
29885400-0	2018	Biological interaction of newly synthesized astaxanthin-s-allyl cysteine biconjugate with Saccharomyces cerevisiae and mammalian alpha-glucosidase: In vitro kinetics and in silico docking analysis.	astaxanthin-s-allyl cysteine	44-72	sucrase-isomaltase	Homo sapiens	129-146
29885400-2	2018	alpha-glucosidase is involved in the hydrolyses of disaccharide into monosaccharides and results in hyperglycemia.	Disaccharides	51-63	sucrase-isomaltase	Homo sapiens	0-17
29885400-2	2018	alpha-glucosidase is involved in the hydrolyses of disaccharide into monosaccharides and results in hyperglycemia.	Monosaccharides	69-84	sucrase-isomaltase	Homo sapiens	0-17
29852990-7	2018	The biosensor may also exhibit good sensitivity for alpha-glucosidase determination with the detection limit 0.005 U/mL and can be reused by water-washing regeneration with good repeatability.	Water	141-146	sucrase-isomaltase	Homo sapiens	52-69
29980114-1	2018	A novel series of acridine linked to thioacetamides 9a-o were synthesized and evaluated for their alpha-glucosidase inhibitory and cytotoxic activities.	Acridines	18-26	sucrase-isomaltase	Homo sapiens	98-115
29980114-2	2018	All the synthesized compounds exhibited excellent alpha-glucosidase inhibitory activity in the range of IC50 = 80.0 +- 2.0-383.1 +- 2.0 microM against yeast alpha-glucosidase, when compared to the standard drug acarbose (IC50 = 750.0 +- 1.5 microM).	Acarbose	211-219	sucrase-isomaltase	Homo sapiens	50-67
29980114-2	2018	All the synthesized compounds exhibited excellent alpha-glucosidase inhibitory activity in the range of IC50 = 80.0 +- 2.0-383.1 +- 2.0 microM against yeast alpha-glucosidase, when compared to the standard drug acarbose (IC50 = 750.0 +- 1.5 microM).	Acarbose	211-219	sucrase-isomaltase	Homo sapiens	157-174
29980114-3	2018	Among the synthesized compounds, 2-((6-chloro-2-methoxyacridin-9-yl)thio)-N-(p-tolyl) acetamide 9b displayed the highest alpha-glucosidase inhibitory activity (IC50 = 80.0 +- 2.0 muM).	2-((6-chloro-2-methoxyacridin-9-yl)thio)-n-(p-tolyl) acetamide	33-95	sucrase-isomaltase	Homo sapiens	121-138
30103106-0	2018	Docking and QSAR analysis of tetracyclic oxindole derivatives as alpha-glucosidase inhibitors.	tetracyclic oxindole	29-49	sucrase-isomaltase	Homo sapiens	65-82
30103106-2	2018	Molecular docking and quantitative structure-activity relationship (QSAR) were performed based on a series of tetracyclic oxindole derivatives to elucidate key structural properties affecting inhibitory activity and support the design of new alpha-glucosidase inhibitors.	tetracyclic oxindole	110-130	sucrase-isomaltase	Homo sapiens	242-259
30103106-9	2018	Generally, the suggested QSAR analysis based on classification, docking and GA-PLS/SVM strategy may help suggest chemical scaffold to design novel oxindole derivatives as alpha-glucosidase inhibitors.	2-oxindole	147-155	sucrase-isomaltase	Homo sapiens	171-188
29842952-0	2018	Structural characterization and alpha-glucosidase inhibitory activity of polysaccharides extracted from Chinese traditional medicine Huidouba.	Polysaccharides	73-88	sucrase-isomaltase	Homo sapiens	32-49
30411010-0	2018	Efficient Synthesis and in Silico Studies of the Benzimidazole Hybrid Scaffold with the Quinolinyloxadiazole Skeleton with Potential alpha-Glucosidase Inhibitory, Anticoagulant, and Antiplatelet Activities for Type-II Diabetes Mellitus Management and Treating Thrombotic Disorders.	benzimidazole	49-62	sucrase-isomaltase	Homo sapiens	133-150
30411010-0	2018	Efficient Synthesis and in Silico Studies of the Benzimidazole Hybrid Scaffold with the Quinolinyloxadiazole Skeleton with Potential alpha-Glucosidase Inhibitory, Anticoagulant, and Antiplatelet Activities for Type-II Diabetes Mellitus Management and Treating Thrombotic Disorders.	quinolinyloxadiazole	88-108	sucrase-isomaltase	Homo sapiens	133-150
30411010-4	2018	In addition, molecular docking studies revealed that benzimidazole-containing quinolinyl oxadiazoles can correctly dock into the target receptor protein of the human intestinal alpha-glucosidase, while their bioavailability/drug-likeness was predicted to be acceptable but requires further optimization.	benzimidazole	53-66	sucrase-isomaltase	Homo sapiens	177-194
30411010-4	2018	In addition, molecular docking studies revealed that benzimidazole-containing quinolinyl oxadiazoles can correctly dock into the target receptor protein of the human intestinal alpha-glucosidase, while their bioavailability/drug-likeness was predicted to be acceptable but requires further optimization.	quinolinyl oxadiazoles	78-100	sucrase-isomaltase	Homo sapiens	177-194
30411010-9	2018	These findings reveal that benzimidazole-containing quinolinyl oxadiazoles act as alpha-glucosidase inhibitors to develop novel therapeutics for treating type-II diabetes mellitus and can act as lead molecules in drug discovery as potential antidiabetic and antithrombotic agents.	benzimidazole	27-40	sucrase-isomaltase	Homo sapiens	82-99
30411010-9	2018	These findings reveal that benzimidazole-containing quinolinyl oxadiazoles act as alpha-glucosidase inhibitors to develop novel therapeutics for treating type-II diabetes mellitus and can act as lead molecules in drug discovery as potential antidiabetic and antithrombotic agents.	quinolinyl oxadiazoles	52-74	sucrase-isomaltase	Homo sapiens	82-99
29857256-0	2018	Investigation of the interaction of 2,4-dimethoxy-6,7-dihydroxyphenanthrene with alpha-glucosidase using inhibition kinetics, CD, FT-IR and molecular docking methods.	2,4-dimethoxy-6,7-dihydroxyphenanthrene	36-75	sucrase-isomaltase	Homo sapiens	81-98
29857256-1	2018	Applying enzyme kinetics, spectroscopic, and molecular docking methods, the interaction properties of 2,4-dimethoxy-6,7-dihydroxyphenanthrene with alpha-glucosidase were systematically investigated.	2,4-dimethoxy-6,7-dihydroxyphenanthrene	102-141	sucrase-isomaltase	Homo sapiens	147-164
29857256-2	2018	The alpha-glucosidase inhibitory activities (IC50 = 0.40 mM) were significantly higher than that of acarbose (as control) and the spectrometric results revealed that 2,4-dimethoxy-6,7-dihydroxyphenanthrene inhibited alpha-glucosidase in a reversible and noncompetitive manner, which is that the inhibitor bind to the inactive region of alpha-glucosidase and could be separated from the bind sites.	-dimethoxy-6,7-dihydroxyphenanthrene	169-205	sucrase-isomaltase	Homo sapiens	4-21
29857256-2	2018	The alpha-glucosidase inhibitory activities (IC50 = 0.40 mM) were significantly higher than that of acarbose (as control) and the spectrometric results revealed that 2,4-dimethoxy-6,7-dihydroxyphenanthrene inhibited alpha-glucosidase in a reversible and noncompetitive manner, which is that the inhibitor bind to the inactive region of alpha-glucosidase and could be separated from the bind sites.	-dimethoxy-6,7-dihydroxyphenanthrene	169-205	sucrase-isomaltase	Homo sapiens	216-233
29857256-2	2018	The alpha-glucosidase inhibitory activities (IC50 = 0.40 mM) were significantly higher than that of acarbose (as control) and the spectrometric results revealed that 2,4-dimethoxy-6,7-dihydroxyphenanthrene inhibited alpha-glucosidase in a reversible and noncompetitive manner, which is that the inhibitor bind to the inactive region of alpha-glucosidase and could be separated from the bind sites.	-dimethoxy-6,7-dihydroxyphenanthrene	169-205	sucrase-isomaltase	Homo sapiens	216-233
29857256-4	2018	The CD studies showed that the content of alpha-helix in alpha-glucosidase increased from 17.2% to 17.8% with the concentration varying of 2,4-dimethoxy-6,7-dihydroxyphenanthrene.	Cadmium	4-6	sucrase-isomaltase	Homo sapiens	57-74
29857256-4	2018	The CD studies showed that the content of alpha-helix in alpha-glucosidase increased from 17.2% to 17.8% with the concentration varying of 2,4-dimethoxy-6,7-dihydroxyphenanthrene.	2,4-dimethoxy-6,7-dihydroxyphenanthrene	139-178	sucrase-isomaltase	Homo sapiens	57-74
29857256-5	2018	The alpha-helix increasing trend (19.70% - 21.43%) of alpha-glucosidase secondary structure was further proved by Fourier transform infrared spectra (FT-IR) results and the FT-IR spectra of alpha-glucosidase resulted in obvious red shift with the addition of 2,4-dimethoxy-6,7-dihydroxyphenanthrene.	2,4-dimethoxy-6,7-dihydroxyphenanthrene	259-298	sucrase-isomaltase	Homo sapiens	54-71
29857256-6	2018	All the measurements proved the interaction of 2,4-dimethoxy-6,7-dihydroxyphenanthrene with alpha-glucosidase and revealed the conformational change of alpha-glucosidase secondary structure.	2,4-dimethoxy-6,7-dihydroxyphenanthrene	47-86	sucrase-isomaltase	Homo sapiens	92-109
29857256-6	2018	All the measurements proved the interaction of 2,4-dimethoxy-6,7-dihydroxyphenanthrene with alpha-glucosidase and revealed the conformational change of alpha-glucosidase secondary structure.	2,4-dimethoxy-6,7-dihydroxyphenanthrene	47-86	sucrase-isomaltase	Homo sapiens	152-169
29894890-0	2018	Synthesis of Bis-indolylmethane sulfonohydrazides derivatives as potent alpha-Glucosidase inhibitors.	bis-indolylmethane sulfonohydrazides	13-49	sucrase-isomaltase	Homo sapiens	72-89
29894890-6	2018	From the docking studies, it was observed that all the active bis-indolylmethane sulfonohydrazides derivatives showed considerable binding interactions within the active site (acarbose inhibition site) of alpha-glucosidase.	bis-indolylmethane sulfonohydrazides	62-98	sucrase-isomaltase	Homo sapiens	205-222
29894890-6	2018	From the docking studies, it was observed that all the active bis-indolylmethane sulfonohydrazides derivatives showed considerable binding interactions within the active site (acarbose inhibition site) of alpha-glucosidase.	Acarbose	176-184	sucrase-isomaltase	Homo sapiens	205-222
30153956-0	2018	Design, synthesis and in vitro study of densely functionalized oxindoles as potent alpha-glucosidase inhibitors.	Oxindoles	63-72	sucrase-isomaltase	Homo sapiens	83-100
30153956-3	2018	Here in we report a new class of oxindole derivatives 6a-kvia scaffold hopping of known alpha-glucosidase inhibitors 1-4.	2-oxindole	33-41	sucrase-isomaltase	Homo sapiens	88-105
29981013-4	2018	Essentially there are two different ways of glycogen degradation localized in different cellular organelles: glycogenolysis or lysosomal breakdown by acid alpha-glucosidase.	Glycogen	44-52	sucrase-isomaltase	Homo sapiens	155-172
29807208-0	2018	Catalytic asymmetric synthesis of indole derivatives as novel alpha-glucosidase inhibitors in vitro.	indole	34-40	sucrase-isomaltase	Homo sapiens	62-79
30282319-0	2018	A comprehensive review on xanthone derivatives as alpha-glucosidase inhibitors.	xanthone	26-34	sucrase-isomaltase	Homo sapiens	50-67
30282319-1	2018	alpha-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications.	Carbohydrates	45-57	sucrase-isomaltase	Homo sapiens	0-17
30282319-3	2018	Herein, a comprehensive review of the literature on xanthones as inhibitors of alpha-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs.	Xanthones	52-61	sucrase-isomaltase	Homo sapiens	79-96
29778797-0	2018	Discovery of potent alpha-glucosidase inhibitor flavonols: Insights into mechanism of action through inhibition kinetics and docking simulations.	Flavonols	48-57	sucrase-isomaltase	Homo sapiens	20-37
29807208-5	2018	To the best of knowledge, this is the first report of the propanone substituted indole ring containing compounds by in vitro alpha-glucosidase enzyme inhibition.	Acetone	58-67	sucrase-isomaltase	Homo sapiens	125-142
29778797-1	2018	Beside other pharmaceutical benefits, flavonoids are known for their potent alpha-glucosidase inhibition.	Flavonoids	38-48	sucrase-isomaltase	Homo sapiens	76-93
29778797-3	2018	It was found that while sugar substitution to C3-OH of C ring reduced the alpha-glucosidase inhibitory effect, galloyl substitution to these sugar units increased it.	Sugars	24-29	sucrase-isomaltase	Homo sapiens	74-91
29807208-5	2018	To the best of knowledge, this is the first report of the propanone substituted indole ring containing compounds by in vitro alpha-glucosidase enzyme inhibition.	indole	80-86	sucrase-isomaltase	Homo sapiens	125-142
30031655-0	2018	Regio- and stereospecific synthesis of rac-carbasugar-based cyclohexane pentols; Investigations of their alpha- and beta-glucosidase inhibitions.	rac-carbasugar	39-53	sucrase-isomaltase	Homo sapiens	105-132
29745030-0	2018	Synthesis and biological evaluation of novel N-aryl-omega-(benzoazol-2-yl)-sulfanylalkanamides as dual inhibitors of alpha-glucosidase and protein tyrosine phosphatase 1B.	n-aryl-omega-(benzoazol-2-yl)-sulfanylalkanamides	45-94	sucrase-isomaltase	Homo sapiens	117-134
29745030-1	2018	alpha-Glucosidase is known to catalyze the digestion of carbohydrates and release free glucose into the digestive tract.	Carbohydrates	56-69	sucrase-isomaltase	Homo sapiens	0-17
29745030-1	2018	alpha-Glucosidase is known to catalyze the digestion of carbohydrates and release free glucose into the digestive tract.	Glucose	87-94	sucrase-isomaltase	Homo sapiens	0-17
29745030-4	2018	In this work, three series of novel N-aryl-omega-(benzoazol-2-yl)-sulfanylalkanamides were synthesized and assayed for their alpha-glucosidase and PTP1B inhibitory activities, respectively.	n-aryl-omega-(benzoazol-2-yl)-sulfanylalkanamides	36-85	sucrase-isomaltase	Homo sapiens	125-142
29745030-8	2018	Molecular docking study indicated that hydrogen bonds, van der Waals, charge interactions and Pi-cation interactions all contributed to affinity between 3l and alpha-glucosidase/PTP1B.	Hydrogen	39-47	sucrase-isomaltase	Homo sapiens	160-177
30031655-0	2018	Regio- and stereospecific synthesis of rac-carbasugar-based cyclohexane pentols; Investigations of their alpha- and beta-glucosidase inhibitions.	cyclohexane pentols	60-79	sucrase-isomaltase	Homo sapiens	105-132
30081555-10	2018	HIOP1-S and HIOP2-S showed strong alpha-glucosidase inhibitory activities and increased the glucose consumption of HepG2 cells.	hiop1-s	0-7	sucrase-isomaltase	Homo sapiens	34-51
30056511-0	2018	Carbon dots doped with nitrogen and boron as ultrasensitive fluorescent probes for determination of alpha-glucosidase activity and its inhibitors in water samples and living cells.	Carbon	0-6	sucrase-isomaltase	Homo sapiens	100-117
30081555-10	2018	HIOP1-S and HIOP2-S showed strong alpha-glucosidase inhibitory activities and increased the glucose consumption of HepG2 cells.	hiop2-s	12-19	sucrase-isomaltase	Homo sapiens	34-51
29597114-1	2018	alpha-Glucosidase is a catabolic enzyme that regulates the body"s plasma glucose levels by providing energy sources to maintain healthy functioning.	Glucose	73-80	sucrase-isomaltase	Homo sapiens	0-17
29597114-2	2018	2-Amino-thiadiazole (1-13) and 2-amino-thiadiazole based Schiff bases (14-22) were synthesized, characterized by 1H NMR and HREI-MS and screened for alpha-glucosidase inhibitory activity.	2-amino-1,3,4-thiadiazole	0-19	sucrase-isomaltase	Homo sapiens	149-166
29597114-2	2018	2-Amino-thiadiazole (1-13) and 2-amino-thiadiazole based Schiff bases (14-22) were synthesized, characterized by 1H NMR and HREI-MS and screened for alpha-glucosidase inhibitory activity.	2-amino-thiadiazole based schiff bases	31-69	sucrase-isomaltase	Homo sapiens	149-166
30056511-0	2018	Carbon dots doped with nitrogen and boron as ultrasensitive fluorescent probes for determination of alpha-glucosidase activity and its inhibitors in water samples and living cells.	Boron	36-41	sucrase-isomaltase	Homo sapiens	100-117
29587132-0	2018	Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of alpha-glucosidase inhibitors.	5,6-diaryl-1,2,4-triazine thiazole	63-97	sucrase-isomaltase	Homo sapiens	128-145
29587132-1	2018	A novel 5,6-diaryl-1,2,4-triazine thiazole derivatives (7a-7q) were synthesized and characterized by 1H NMR and 13C NMR and evaluated for their alpha-glucosidase inhibitory activity.	5,6-diaryl-1,2,4-triazine thiazole	8-42	sucrase-isomaltase	Homo sapiens	144-161
29587132-1	2018	A novel 5,6-diaryl-1,2,4-triazine thiazole derivatives (7a-7q) were synthesized and characterized by 1H NMR and 13C NMR and evaluated for their alpha-glucosidase inhibitory activity.	7a-7q	56-61	sucrase-isomaltase	Homo sapiens	144-161
29587132-2	2018	All tested compounds displayed good alpha-glucosidase inhibitory activity with IC50 values ranging between 2.85 +- 0.13 and 14.19 +- 0.23 muM when compared to the standard drug acarbose (IC50 = 817.38 +- 6.27 muM).	Acarbose	177-185	sucrase-isomaltase	Homo sapiens	36-53
29587132-5	2018	This study showed that these 5,6-diaryl-1,2,4-triazine thiazole derivatives are a new class of alpha-glucosidase inhibitors.	5,6-diaryl-1,2,4-triazine thiazole	29-63	sucrase-isomaltase	Homo sapiens	95-112
29761590-4	2018	In this report, we present structures of Ro-alphaG1 in complex with the antidiabetic alpha-glucosidase inhibitors voglibose, miglitol, and acarbose and supporting binding data.	voglibose	114-123	sucrase-isomaltase	Homo sapiens	85-102
29761590-4	2018	In this report, we present structures of Ro-alphaG1 in complex with the antidiabetic alpha-glucosidase inhibitors voglibose, miglitol, and acarbose and supporting binding data.	miglitol	125-133	sucrase-isomaltase	Homo sapiens	85-102
29761590-4	2018	In this report, we present structures of Ro-alphaG1 in complex with the antidiabetic alpha-glucosidase inhibitors voglibose, miglitol, and acarbose and supporting binding data.	Acarbose	139-147	sucrase-isomaltase	Homo sapiens	85-102
30056511-3	2018	4-Nitrophenylglucoside is added and then hydrolyzed by alpha-glucosidase to form yellow 4-nitrophenol which screens off fluorescence due to an inner filter effect.	4-nitrophenyl beta-D-glucoside	0-22	sucrase-isomaltase	Homo sapiens	55-72
30056511-3	2018	4-Nitrophenylglucoside is added and then hydrolyzed by alpha-glucosidase to form yellow 4-nitrophenol which screens off fluorescence due to an inner filter effect.	4-nitrophenol	88-101	sucrase-isomaltase	Homo sapiens	55-72
30056511-5	2018	It was subsequently applied to the determination of the alpha-glucosidase inhibitor acarbose which can be determined in a concentration as low as 10 nM (at three times the standard deviation versus slope).	Acarbose	84-92	sucrase-isomaltase	Homo sapiens	56-73
30056511-0	2018	Carbon dots doped with nitrogen and boron as ultrasensitive fluorescent probes for determination of alpha-glucosidase activity and its inhibitors in water samples and living cells.	Nitrogen	23-31	sucrase-isomaltase	Homo sapiens	100-117
30056511-8	2018	Graphical abstract N,B-CDs as ultrasensitive fluorescence probe for alpha-glucosidase activity and its inhibitor in waters and living cells based on IFE.	n,b-cds	19-26	sucrase-isomaltase	Homo sapiens	68-85
29634968-0	2018	Integrated multi-spectroscopic and molecular docking techniques to probe the interaction mechanism between maltase and 1-deoxynojirimycin, an alpha-glucosidase inhibitor.	1-DEOXYNOJIRIMYCIN	119-137	sucrase-isomaltase	Homo sapiens	142-159
29776833-0	2018	Novel oxazolxanthone derivatives as a new type of alpha-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect.	oxazolxanthone	6-20	sucrase-isomaltase	Homo sapiens	50-67
29776833-1	2018	Xanthone derivatives have shown good alpha-glucosidase inhibitory activity and have drawn increased attention as potential anti-diabetic compounds.	xanthone	0-8	sucrase-isomaltase	Homo sapiens	37-54
29776833-2	2018	In this study, a series of novel oxazolxanthones were designed, synthesized, and investigated as alpha-glucosidase inhibitors.	oxazolxanthones	33-48	sucrase-isomaltase	Homo sapiens	97-114
29776833-4	2018	Among them, compounds 5-21 (IC50 = 6.3 +- 0.4-38.5 +- 4.6 muM) were more active than 1-deoxynojirimycin (IC50 = 60.2 +- 6.2 muM), a well-known alpha-glucosidase inhibitor.	1-DEOXYNOJIRIMYCIN	85-103	sucrase-isomaltase	Homo sapiens	143-160
29634968-1	2018	Interaction mechanism of an antidiabetic agent, 1-deoxynojirimycin (DNJ) with its target protein alpha-glucosidase (maltase), was investigated by kinetics, fluorescence spectroscopy, UV-vis spectroscopy, circular dichroism, dynamic light scattering coupled with molecular docking analysis.	1-DEOXYNOJIRIMYCIN	48-66	sucrase-isomaltase	Homo sapiens	97-114
29634968-1	2018	Interaction mechanism of an antidiabetic agent, 1-deoxynojirimycin (DNJ) with its target protein alpha-glucosidase (maltase), was investigated by kinetics, fluorescence spectroscopy, UV-vis spectroscopy, circular dichroism, dynamic light scattering coupled with molecular docking analysis.	1-DEOXYNOJIRIMYCIN	68-71	sucrase-isomaltase	Homo sapiens	97-114
29902001-3	2018	BA bound with alpha-glucosidase to form a BA-alpha-glucosidase complex, resulting in a more compact structure of the enzyme.	betulinic acid	0-2	sucrase-isomaltase	Homo sapiens	45-62
29902001-5	2018	Molecular docking showed that BA tightly bound to the active cavity of alpha-glucosidase, which might hinder the entrance of the substrate leading to a decline in enzyme activity.	betulinic acid	30-32	sucrase-isomaltase	Homo sapiens	71-88
29902001-0	2018	New Insights into the Inhibition Mechanism of Betulinic Acid on alpha-Glucosidase.	betulinic acid	46-60	sucrase-isomaltase	Homo sapiens	64-81
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Histidine	183-186	sucrase-isomaltase	Homo sapiens	29-46
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Tyrosine	192-195	sucrase-isomaltase	Homo sapiens	29-46
29902001-2	2018	In this study, BA was found to exhibit stronger inhibition of alpha-glucosidase than acarbose with an IC50 value of (1.06 +- 0.02) x 10-5 mol L-1 in a mixed-type manner.	betulinic acid	15-17	sucrase-isomaltase	Homo sapiens	62-79
29902001-3	2018	BA bound with alpha-glucosidase to form a BA-alpha-glucosidase complex, resulting in a more compact structure of the enzyme.	betulinic acid	0-2	sucrase-isomaltase	Homo sapiens	14-31
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Lysine	201-204	sucrase-isomaltase	Homo sapiens	29-46
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Arginine	210-213	sucrase-isomaltase	Homo sapiens	29-46
28950431-1	2018	AIMS/INTRODUCTION: The combination of dipeptidyl peptidase-4 (DPP4) inhibitors and alpha-glucosidase inhibitors (AGIs) might provide an additive or synergistic glucose-lowering effect, as they have a complementary mode of action.	Glucose	160-167	sucrase-isomaltase	Homo sapiens	83-100
29641985-0	2018	LC-MS guided isolation of diterpenoids from Sapium insigne with alpha-glucosidase inhibitory activities.	Diterpenes	26-38	sucrase-isomaltase	Homo sapiens	64-81
29641985-6	2018	The preliminary structure-activity relationships of the ent-atisane diterpenoids inhibiting alpha-glucosidase were discussed.	atisane	60-67	sucrase-isomaltase	Homo sapiens	92-109
29641985-6	2018	The preliminary structure-activity relationships of the ent-atisane diterpenoids inhibiting alpha-glucosidase were discussed.	Diterpenes	68-80	sucrase-isomaltase	Homo sapiens	92-109
29477543-0	2018	Inhibitory effect of raspberry ketone on alpha-glucosidase: Docking simulation integrating inhibition kinetics.	raspberry ketone	21-37	sucrase-isomaltase	Homo sapiens	41-58
29477543-2	2018	In this regard, we conducted enzyme kinetics integrated with computational docking simulation to assess the inhibitory effect of raspberry ketone (RK) on alpha-glucosidase.	raspberry ketone	129-145	sucrase-isomaltase	Homo sapiens	154-171
29327320-4	2018	These isolate extracts exhibit the highest reducing activities against carbohydrate-metabolizing enzymes including alpha-amylase, alpha-glucosidase, beta-glucosidase, beta-glucuronidase, and tyrosinase.	Carbohydrates	71-83	sucrase-isomaltase	Homo sapiens	130-147
29465310-1	2018	Dietary starch is finally converted to glucose for absorption by the small intestine mucosal alpha-glucosidases (sucrase-isomaltase [SI] and maltase-glucoamylase), and control of this process has health implications.	Starch	8-14	sucrase-isomaltase	Homo sapiens	113-131
29465310-1	2018	Dietary starch is finally converted to glucose for absorption by the small intestine mucosal alpha-glucosidases (sucrase-isomaltase [SI] and maltase-glucoamylase), and control of this process has health implications.	Glucose	39-46	sucrase-isomaltase	Homo sapiens	113-131
29329813-2	2018	Some physicochemical properties, including structure, monosaccharide composition, and molecular weight distribution, as well as the 4 in vitro antioxidant activities and inhibitory effects on alpha-glucosidase of above polysaccharides before and after removing metal ions were investigated.	Polysaccharides	219-234	sucrase-isomaltase	Homo sapiens	192-209
29329813-3	2018	By comparing TTPS and TPSII, we found that they exhibited different antioxidant activities and inhibitory actions against alpha-glucosidase after their metal ions were removed.	Metals	152-157	sucrase-isomaltase	Homo sapiens	122-139
29677678-1	2018	During the last decade, ursolic and oleanolic acids have been of considerable interest because of their alpha-glucosidase inhibitory activities and potential effects for treatment of type 2 diabetes.	ursolic	24-31	sucrase-isomaltase	Homo sapiens	104-121
29478524-6	2018	Anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, were strong inhibitors of alpha-amylase and alpha-glucosidase.	Anthocyanins	0-12	sucrase-isomaltase	Homo sapiens	106-123
29478524-6	2018	Anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, were strong inhibitors of alpha-amylase and alpha-glucosidase.	cyanidin 3-rutinoside	14-35	sucrase-isomaltase	Homo sapiens	106-123
29478524-6	2018	Anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, were strong inhibitors of alpha-amylase and alpha-glucosidase.	cyanidin-3-o-glucoside	40-60	sucrase-isomaltase	Homo sapiens	106-123
29897983-1	2018	1-Deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor and thus beneficial for prevention of diabetes.	1-Deoxynojirimycin	0-18	sucrase-isomaltase	Homo sapiens	37-54
29897983-1	2018	1-Deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor and thus beneficial for prevention of diabetes.	1-Deoxynojirimycin	20-23	sucrase-isomaltase	Homo sapiens	37-54
29677678-1	2018	During the last decade, ursolic and oleanolic acids have been of considerable interest because of their alpha-glucosidase inhibitory activities and potential effects for treatment of type 2 diabetes.	Oleanolic Acid	36-51	sucrase-isomaltase	Homo sapiens	104-121
29744906-3	2018	Enzyme inhibition profiles were detected by the UV detector at 415 nm based on the reaction of alpha-glucosidase and p-nitrophenyl alpha-d-glucopyranoside (PNPG).	4-nitrophenyl alpha-glucoside	156-160	sucrase-isomaltase	Homo sapiens	95-112
29762368-1	2018	Complete digestion of the glycemic carbohydrates to glucose takes place through the combined action of the 4 mucosal alpha-glucosidases (maltase-glucoamylase and sucrase-isomaltase) in the small intestine.	glycemic carbohydrates	26-48	sucrase-isomaltase	Homo sapiens	162-180
29762368-1	2018	Complete digestion of the glycemic carbohydrates to glucose takes place through the combined action of the 4 mucosal alpha-glucosidases (maltase-glucoamylase and sucrase-isomaltase) in the small intestine.	Glucose	52-59	sucrase-isomaltase	Homo sapiens	162-180
29762369-1	2018	OBJECTIVES: Maltase-glucoamylase and sucrase-isomaltase are enzymes in the brush-border membrane of the small intestinal lumen responsible for the breakdown of postamylase starch polysaccharides to release monomeric glucose.	Starch	172-178	sucrase-isomaltase	Homo sapiens	37-55
29762369-1	2018	OBJECTIVES: Maltase-glucoamylase and sucrase-isomaltase are enzymes in the brush-border membrane of the small intestinal lumen responsible for the breakdown of postamylase starch polysaccharides to release monomeric glucose.	Polysaccharides	179-194	sucrase-isomaltase	Homo sapiens	37-55
29762369-1	2018	OBJECTIVES: Maltase-glucoamylase and sucrase-isomaltase are enzymes in the brush-border membrane of the small intestinal lumen responsible for the breakdown of postamylase starch polysaccharides to release monomeric glucose.	Glucose	216-223	sucrase-isomaltase	Homo sapiens	37-55
29425876-0	2018	Inhibitory effect of pyrogallol on alpha-glucosidase: Integrating docking simulations with inhibition kinetics.	Pyrogallol	21-31	sucrase-isomaltase	Homo sapiens	35-52
29425876-1	2018	In this study we conducted serial kinetic studies integrated with computational simulations to judge the inhibitory effect of pyrogallol on alpha-glucosidase, due to the association between this enzyme and the treatment of type 2 diabetes.	Pyrogallol	126-136	sucrase-isomaltase	Homo sapiens	140-157
29425876-2	2018	As a result, we found that pyrogallol bound to the active site of alpha-glucosidase, interacting with several key residues, such as ASP68, MET69, TYR71, PHE157, PHE158, PHE177, GLN181, HIS348, ASP349, ASP406, VAL407, ASP408, ARG439, and ARG443, which was predicted by performing a protein-ligand docking simulation.	Pyrogallol	27-37	sucrase-isomaltase	Homo sapiens	66-83
29425876-3	2018	Subsequently, we evaluated the inhibitory effect of pyrogallol on alpha-glucosidase, and found that it induced a mixed type of inhibition in a reversible and quick-binding manner.	Pyrogallol	52-62	sucrase-isomaltase	Homo sapiens	66-83
29425876-6	2018	Our study provides insight into the functional inhibitory role of pyrogallol, which results from its triple-hydroxyl groups interacting with the active site of alpha-glucosidase.	Pyrogallol	66-76	sucrase-isomaltase	Homo sapiens	160-177
29425876-7	2018	We suggest that compounds similar to pyrogallol (phenolic hydroxyl compounds) which target the key residues of the active site of alpha-glucosidase could be potential agents for alpha-glucosidase inhibition.	Pyrogallol	37-47	sucrase-isomaltase	Homo sapiens	130-147
29425876-7	2018	We suggest that compounds similar to pyrogallol (phenolic hydroxyl compounds) which target the key residues of the active site of alpha-glucosidase could be potential agents for alpha-glucosidase inhibition.	Pyrogallol	37-47	sucrase-isomaltase	Homo sapiens	178-195
29762371-1	2018	The final step of carbohydrate digestion in the intestine is performed by 2 major alpha-glucosidases of the intestinal mucosa, sucrase-isomaltase (SI) and maltase-glucoamylase.	Carbohydrates	18-30	sucrase-isomaltase	Homo sapiens	127-145
29762374-4	2018	Starch digestion is affected by its susceptibility to alpha-amylase and alpha-glucosidase (maltase), and the susceptibility is determined by starch granule architecture and glucan structures, as well as the interaction between starch and other food components.	Starch	0-6	sucrase-isomaltase	Homo sapiens	72-89
29744906-5	2018	Four components in green tea showed alpha-glucosidase inhibition action and three of them were identified as HHDP-galloyl glucose, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate by HPLC-fourier-transform mass spectrometry (HPLC-FTMS).	epicatechin gallate	166-191	sucrase-isomaltase	Homo sapiens	36-53
29548257-2	2018	alpha-Glucosidase enzymes contribute to the digestion of starch into glucose and are thus attractive therapeutic targets for diabetes.	Starch	57-63	sucrase-isomaltase	Homo sapiens	0-17
29854557-0	2018	Characterization of alpha-Glucosidase Inhibitor/Cyclodextrin Complex Prepared by Freeze-Drying.	Cyclodextrins	48-60	sucrase-isomaltase	Homo sapiens	20-37
29854557-1	2018	Miglitol (MT) is an alpha-glucosidase inhibitor with a postmeal blood glucose level lowering effect that is used to treat type 2 diabetes.	Glucose	70-77	sucrase-isomaltase	Homo sapiens	20-37
29287449-5	2018	The antioxidant capacity and the alpha-glucosidase inhibitory activity of the duodenal extract correlated with the amount of ASP in the bread.	Aspartic Acid	125-128	sucrase-isomaltase	Homo sapiens	33-50
29676183-0	2018	Synthesis &amp; alpha-glucosidase inhibitory &amp; glucose consumption-promoting activities of flavonoid-coumarin hybrids.	Adenosine Monophosphate	11-14	sucrase-isomaltase	Homo sapiens	16-33
29676183-0	2018	Synthesis &amp; alpha-glucosidase inhibitory &amp; glucose consumption-promoting activities of flavonoid-coumarin hybrids.	Adenosine Monophosphate	46-49	sucrase-isomaltase	Homo sapiens	16-33
29676183-0	2018	Synthesis &amp; alpha-glucosidase inhibitory &amp; glucose consumption-promoting activities of flavonoid-coumarin hybrids.	Glucose	51-58	sucrase-isomaltase	Homo sapiens	16-33
29676183-0	2018	Synthesis &amp; alpha-glucosidase inhibitory &amp; glucose consumption-promoting activities of flavonoid-coumarin hybrids.	Flavonoids	95-104	sucrase-isomaltase	Homo sapiens	16-33
29676183-0	2018	Synthesis &amp; alpha-glucosidase inhibitory &amp; glucose consumption-promoting activities of flavonoid-coumarin hybrids.	coumarin	105-113	sucrase-isomaltase	Homo sapiens	16-33
29676183-4	2018	Results &amp; methodology: Compounds (5a) and (14a) were identified as new alpha-glucosidase and alpha-amylase dual inhibitors.	Adenosine Monophosphate	9-12	sucrase-isomaltase	Homo sapiens	75-92
29668036-4	2018	Also we found GSAE samples containing catechin and epicatechin were 44.12 +- 0.21 mg/mL, 111.23 +- 1.29 mg/g, GSAE against alpha-glucosidase IC50 was 25.25 +- 0.53 g/mL and GSAE against alpha-amylase IC50 was 66.68 +- 1.1 g/mL, both were competitive way, the effects of Inhibitory were obviously better than that of acarbose.	gsae	14-18	sucrase-isomaltase	Homo sapiens	123-140
29668036-4	2018	Also we found GSAE samples containing catechin and epicatechin were 44.12 +- 0.21 mg/mL, 111.23 +- 1.29 mg/g, GSAE against alpha-glucosidase IC50 was 25.25 +- 0.53 g/mL and GSAE against alpha-amylase IC50 was 66.68 +- 1.1 g/mL, both were competitive way, the effects of Inhibitory were obviously better than that of acarbose.	gsae	110-114	sucrase-isomaltase	Homo sapiens	123-140
29668036-4	2018	Also we found GSAE samples containing catechin and epicatechin were 44.12 +- 0.21 mg/mL, 111.23 +- 1.29 mg/g, GSAE against alpha-glucosidase IC50 was 25.25 +- 0.53 g/mL and GSAE against alpha-amylase IC50 was 66.68 +- 1.1 g/mL, both were competitive way, the effects of Inhibitory were obviously better than that of acarbose.	gsae	110-114	sucrase-isomaltase	Homo sapiens	123-140
29668036-4	2018	Also we found GSAE samples containing catechin and epicatechin were 44.12 +- 0.21 mg/mL, 111.23 +- 1.29 mg/g, GSAE against alpha-glucosidase IC50 was 25.25 +- 0.53 g/mL and GSAE against alpha-amylase IC50 was 66.68 +- 1.1 g/mL, both were competitive way, the effects of Inhibitory were obviously better than that of acarbose.	Acarbose	316-324	sucrase-isomaltase	Homo sapiens	123-140
29668036-8	2018	The results showed that grape seeds were rich in anthocyanins and polyphenols and other active substances, inhibited alpha-glucosidase and alpha-amylase activity, which provide background and practical knowledge for the deep-processed products of grape seeds with high added value.	Anthocyanins	49-61	sucrase-isomaltase	Homo sapiens	117-134
29668036-8	2018	The results showed that grape seeds were rich in anthocyanins and polyphenols and other active substances, inhibited alpha-glucosidase and alpha-amylase activity, which provide background and practical knowledge for the deep-processed products of grape seeds with high added value.	Polyphenols	66-77	sucrase-isomaltase	Homo sapiens	117-134
29518717-0	2018	Synthesis, molecular modeling and evaluation of alpha-glucosidase inhibition activity of 3,4-dihydroxy piperidines.	3,4-dihydroxy piperidines	89-114	sucrase-isomaltase	Homo sapiens	48-65
29518717-1	2018	Biological evaluation of 3,4-dihydroxy piperidines as alpha-glucosidase inhibitors is being reported for the first time.	3,4-dihydroxy piperidines	25-50	sucrase-isomaltase	Homo sapiens	54-71
29548257-2	2018	alpha-Glucosidase enzymes contribute to the digestion of starch into glucose and are thus attractive therapeutic targets for diabetes.	Glucose	69-76	sucrase-isomaltase	Homo sapiens	0-17
29606113-7	2018	The effect of HAEF on carbohydrate digestive enzymes alpha-glucosidase and alpha-amylase was studied using biochemical assays.	Carbohydrates	22-34	sucrase-isomaltase	Homo sapiens	53-70
29454828-0	2018	Evaluation of alpha-glucosidase inhibiting potentials with docking calculations of synthesized arylidene-pyrazolones.	arylidene-pyrazolones	95-116	sucrase-isomaltase	Homo sapiens	14-31
29454828-1	2018	Herein, condensation of aryl(hetaryl)pyrazole-4-carbaldehydes 1(a-c) with substituted pyrazolones 2(a-d) lead to the corresponding arylidene-pyrazolones 3(a-l) which were tested against alpha-glucosidase enzyme.	aryl(hetaryl)pyrazole-4-carbaldehydes	24-61	sucrase-isomaltase	Homo sapiens	186-203
29454828-1	2018	Herein, condensation of aryl(hetaryl)pyrazole-4-carbaldehydes 1(a-c) with substituted pyrazolones 2(a-d) lead to the corresponding arylidene-pyrazolones 3(a-l) which were tested against alpha-glucosidase enzyme.	Pyrazolones	86-97	sucrase-isomaltase	Homo sapiens	186-203
29454828-1	2018	Herein, condensation of aryl(hetaryl)pyrazole-4-carbaldehydes 1(a-c) with substituted pyrazolones 2(a-d) lead to the corresponding arylidene-pyrazolones 3(a-l) which were tested against alpha-glucosidase enzyme.	arylidene-pyrazolones	131-152	sucrase-isomaltase	Homo sapiens	186-203
29477126-0	2018	Synthesis, alpha-glucosidase inhibition and molecular docking study of coumarin based derivatives.	coumarin	71-79	sucrase-isomaltase	Homo sapiens	11-28
29477126-2	2018	Among the series, all derivatives exhibited outstanding alpha-glucosidase inhibition with IC50 values ranging between 1.10 +- 0.01 and 36.46 +- 0.70 muM when compared with the standard inhibitor acarbose having IC50 value 39.45 +- 0.10 muM.	Acarbose	195-203	sucrase-isomaltase	Homo sapiens	56-73
29610554-11	2018	The results in vitro showed that soy isoflavones showed a potent inhibitory effect on intestinal alpha-glucosidase, but not on pancreatic alpha-amylase.	Isoflavones	37-48	sucrase-isomaltase	Homo sapiens	97-114
29421697-2	2018	The inhibition of alpha-glucosidase, a key carbohydrate hydrolyzing enzyme, could serve as one of the effective methodology in both preventing and treating diabetes through controlling the postprandial glucose levels and suppressing postprandial hyperglycemia.	Glucose	202-209	sucrase-isomaltase	Homo sapiens	18-35
29421697-5	2018	Compound 6f containing 4,4"-oxydianiline linker was identified as the lead and selective inhibitor of alpha-glucosidase enzyme with an IC50 value of 0.07 +- 0.001 muM (acarbose: IC50 = 38.2 +- 0.12 muM).	di-(4-aminophenyl)ether	23-40	sucrase-isomaltase	Homo sapiens	102-119
29421697-0	2018	A new entry into the portfolio of alpha-glucosidase inhibitors as potent therapeutics for type 2 diabetes: Design, bioevaluation and one-pot multi-component synthesis of diamine-bridged coumarinyl oxadiazole conjugates.	Diamines	170-177	sucrase-isomaltase	Homo sapiens	34-51
29421697-0	2018	A new entry into the portfolio of alpha-glucosidase inhibitors as potent therapeutics for type 2 diabetes: Design, bioevaluation and one-pot multi-component synthesis of diamine-bridged coumarinyl oxadiazole conjugates.	coumarinyl oxadiazole	186-207	sucrase-isomaltase	Homo sapiens	34-51
29421697-2	2018	The inhibition of alpha-glucosidase, a key carbohydrate hydrolyzing enzyme, could serve as one of the effective methodology in both preventing and treating diabetes through controlling the postprandial glucose levels and suppressing postprandial hyperglycemia.	Carbohydrates	43-55	sucrase-isomaltase	Homo sapiens	18-35
29273414-4	2018	Compound 5 was found to be a potent inhibitor (IC50=5.1+-0.1muM) of alpha-glucosidase as compared to acarbose (IC50=625.0+-1muM) used as standard drug.	Acarbose	101-109	sucrase-isomaltase	Homo sapiens	68-85
29287256-7	2018	These synthesized compounds were then evaluated for their alpha-glucosidase inhibitory potential and seven compounds demonstrated an inhibitory potential much better than the standard acarbose.	Acarbose	184-192	sucrase-isomaltase	Homo sapiens	58-75
29232634-0	2018	Biological evaluation of new imidazole derivatives tethered with indole moiety as potent alpha-glucosidase inhibitors.	imidazole	29-38	sucrase-isomaltase	Homo sapiens	89-106
29232634-0	2018	Biological evaluation of new imidazole derivatives tethered with indole moiety as potent alpha-glucosidase inhibitors.	indole	65-71	sucrase-isomaltase	Homo sapiens	89-106
29232634-1	2018	A series of triarylimidazoles substituted with 2-arylindoles (4a-4j) were prepared and evaluated for their in vitro alpha-Glucosidase inhibition.	triarylimidazoles	12-29	sucrase-isomaltase	Homo sapiens	116-133
29232634-2	2018	alpha-Glucosidase inhibition assay displayed a new class of highly potent agents The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose.	acrabose	194-202	sucrase-isomaltase	Homo sapiens	0-17
29232634-2	2018	alpha-Glucosidase inhibition assay displayed a new class of highly potent agents The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose.	acrabose	194-202	sucrase-isomaltase	Homo sapiens	118-135
28884942-3	2018	So far, a total of 43 fully sequenced alpha-glucosidase inhibitory peptides have been reported and 13 of them had IC50 values several folds lower than acarbose.	Acarbose	151-159	sucrase-isomaltase	Homo sapiens	38-55
29292226-0	2018	In vitro and in silico evaluations of diarylpentanoid series as alpha-glucosidase inhibitor.	diarylpentanoid	38-53	sucrase-isomaltase	Homo sapiens	64-81
29292226-1	2018	A series of thirty-four diarylpentanoids derivatives were synthesized and evaluated for their alpha-glucosidase inhibitory activity.	diarylpentanoids	24-40	sucrase-isomaltase	Homo sapiens	94-111
29292226-4	2018	Meanwhile, 3,4-dihydroxyphenyl and furanyl moieties were found to be crucial in improving alpha-glucosidase inhibition.	3,4-dihydroxyphenyl	11-30	sucrase-isomaltase	Homo sapiens	90-107
29292226-4	2018	Meanwhile, 3,4-dihydroxyphenyl and furanyl moieties were found to be crucial in improving alpha-glucosidase inhibition.	furanyl	35-42	sucrase-isomaltase	Homo sapiens	90-107
29292226-5	2018	Molecular docking analyses further confirmed the critical role of both 3,4-dihydroxyphenyl and furanyl moieties as they bound to alpha-glucosidase active site in different mode.	3,4-dihydroxyphenyl	71-90	sucrase-isomaltase	Homo sapiens	129-146
29292226-5	2018	Molecular docking analyses further confirmed the critical role of both 3,4-dihydroxyphenyl and furanyl moieties as they bound to alpha-glucosidase active site in different mode.	furanyl	95-102	sucrase-isomaltase	Homo sapiens	129-146
29292226-6	2018	Overall result suggests that diarylpentanoids with both five membered heterocyclic ring and polyhydroxyphenyl moiety could be a new lead design in the search of novel alpha-glucosidase inhibitor.	diarylpentanoids	29-45	sucrase-isomaltase	Homo sapiens	167-184
28884942-8	2018	Molecular docking of SQSPA, STYV, and STY (digestion fragment of STYV) with alpha-glucosidase suggested that their hydrogen bonding interactions and binding energies were comparable with acarbose.	Hydrogen	115-123	sucrase-isomaltase	Homo sapiens	76-93
28884942-8	2018	Molecular docking of SQSPA, STYV, and STY (digestion fragment of STYV) with alpha-glucosidase suggested that their hydrogen bonding interactions and binding energies were comparable with acarbose.	Acarbose	187-195	sucrase-isomaltase	Homo sapiens	76-93
28958819-0	2018	Inhibitory activity of (-)-epicatechin-3,5-O-digallate on alpha-glucosidase and in silico analysis.	(-)-epicatechin-3,5-o-digallate	23-54	sucrase-isomaltase	Homo sapiens	58-75
29030193-0	2018	Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on alpha-glucosidase.	Oleanolic Acid	51-65	sucrase-isomaltase	Homo sapiens	86-103
29223804-0	2018	Oxindole based oxadiazole hybrid analogs: Novel alpha-glucosidase inhibitors.	2-oxindole	0-8	sucrase-isomaltase	Homo sapiens	48-65
29223804-0	2018	Oxindole based oxadiazole hybrid analogs: Novel alpha-glucosidase inhibitors.	Oxadiazoles	15-25	sucrase-isomaltase	Homo sapiens	48-65
29223804-3	2018	Keeping in view the greater importance of alpha-glucosidase inhibitors here in this study we are presenting oxindole based oxadiazoles hybrid analogs (1-20) synthesis, characterized by different spectroscopic techniques including 1H NMR and EI-MS and their alpha-glucosidase inhibitory activity.	2-oxindole	108-116	sucrase-isomaltase	Homo sapiens	42-59
29223804-3	2018	Keeping in view the greater importance of alpha-glucosidase inhibitors here in this study we are presenting oxindole based oxadiazoles hybrid analogs (1-20) synthesis, characterized by different spectroscopic techniques including 1H NMR and EI-MS and their alpha-glucosidase inhibitory activity.	2-oxindole	108-116	sucrase-isomaltase	Homo sapiens	257-274
29223804-3	2018	Keeping in view the greater importance of alpha-glucosidase inhibitors here in this study we are presenting oxindole based oxadiazoles hybrid analogs (1-20) synthesis, characterized by different spectroscopic techniques including 1H NMR and EI-MS and their alpha-glucosidase inhibitory activity.	Oxadiazoles	123-134	sucrase-isomaltase	Homo sapiens	42-59
29223804-3	2018	Keeping in view the greater importance of alpha-glucosidase inhibitors here in this study we are presenting oxindole based oxadiazoles hybrid analogs (1-20) synthesis, characterized by different spectroscopic techniques including 1H NMR and EI-MS and their alpha-glucosidase inhibitory activity.	Oxadiazoles	123-134	sucrase-isomaltase	Homo sapiens	257-274
29030193-0	2018	Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on alpha-glucosidase.	ursolic acid	70-82	sucrase-isomaltase	Homo sapiens	86-103
29030193-2	2018	This work is to investigate the kinetics and inhibition mechanism of oleanolic acid and ursolic acid on alpha-glucosidase.	Oleanolic Acid	69-83	sucrase-isomaltase	Homo sapiens	104-121
28958819-1	2018	(-)-Epicatechin-3,5-O-digallate (ECDG) from Orostachys japonicus A. Berger was examined for inhibitory activity on alpha-glucosidase.	(-)-epicatechin-3,5-o-digallate	0-31	sucrase-isomaltase	Homo sapiens	115-132
29030193-2	2018	This work is to investigate the kinetics and inhibition mechanism of oleanolic acid and ursolic acid on alpha-glucosidase.	ursolic acid	88-100	sucrase-isomaltase	Homo sapiens	104-121
29030193-5	2018	The binding constants of oleanolic acid and ursolic acid with alpha-glucosidase at 298K were (2.04+-0.02)x103 and (1.87+-0.02)x103Lmol-1, respectively.	Oleanolic Acid	25-39	sucrase-isomaltase	Homo sapiens	62-79
28958819-3	2018	Through the enzyme kinetic analysis, ECDG was shown to act as a competitive inhibitor of alpha-glucosidase by binding to the receptor active site.	ecdg	37-41	sucrase-isomaltase	Homo sapiens	89-106
29030193-5	2018	The binding constants of oleanolic acid and ursolic acid with alpha-glucosidase at 298K were (2.04+-0.02)x103 and (1.87+-0.02)x103Lmol-1, respectively.	ursolic acid	44-56	sucrase-isomaltase	Homo sapiens	62-79
29368615-0	2018	Glitazones and alpha-glucosidase inhibitors as the second-line oral anti-diabetic agents added to metformin reduce cardiovascular risk in Type 2 diabetes patients: a nationwide cohort observational study.	Metformin	98-107	sucrase-isomaltase	Homo sapiens	15-32
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	124-141
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	233-250
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	ursolic acid	47-59	sucrase-isomaltase	Homo sapiens	124-141
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	ursolic acid	47-59	sucrase-isomaltase	Homo sapiens	233-250
29030193-8	2018	The combination of oleanolic acid and ursolic acid displayed a significant synergistic inhibition on alpha-glucosidase.	Oleanolic Acid	19-33	sucrase-isomaltase	Homo sapiens	101-118
29030193-8	2018	The combination of oleanolic acid and ursolic acid displayed a significant synergistic inhibition on alpha-glucosidase.	ursolic acid	38-50	sucrase-isomaltase	Homo sapiens	101-118
29152897-4	2018	After incubation with alpha-glucosidase in vitro, the methanol extract with an IC50 value of 0.19 mg/mL exhibited significant inhibitory activity.	Methanol	54-62	sucrase-isomaltase	Homo sapiens	22-39
29710045-6	2018	Naphthoquinones exert their antidiabetic effects through various mechanisms such as the inhibition of alpha-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2 translocations, enhanced peroxisome proliferator-activated receptor gamma (PPARgamma) ligand activity, and by normalizing carbohydrate metabolizing enzymes in the liver.	Naphthoquinones	0-15	sucrase-isomaltase	Homo sapiens	102-119
29161006-0	2018	ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum alpha-Glucosidase II Exhibiting Antiflaviviral Activity.	TOPS	0-3	sucrase-isomaltase	Homo sapiens	56-73
29161006-0	2018	ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum alpha-Glucosidase II Exhibiting Antiflaviviral Activity.	1-Deoxynojirimycin	4-7	sucrase-isomaltase	Homo sapiens	56-73
29161006-5	2018	ToP-DNJ inhibits ER alpha-glucosidase II at low micromolar concentrations and selectively accumulates in the liver in vivo.	1-Deoxynojirimycin	4-7	sucrase-isomaltase	Homo sapiens	20-37
29342865-1	2018	(Poly)phenols and, specifically, phlorotannins present in brown seaweeds have previously been shown to inhibit alpha-amylase and alpha-glucosidase, key enzymes involved in the breakdown and intestinal absorption of carbohydrates.	Polyphenols	0-13	sucrase-isomaltase	Homo sapiens	129-146
29342865-1	2018	(Poly)phenols and, specifically, phlorotannins present in brown seaweeds have previously been shown to inhibit alpha-amylase and alpha-glucosidase, key enzymes involved in the breakdown and intestinal absorption of carbohydrates.	phlorotannins	33-46	sucrase-isomaltase	Homo sapiens	129-146
29342865-1	2018	(Poly)phenols and, specifically, phlorotannins present in brown seaweeds have previously been shown to inhibit alpha-amylase and alpha-glucosidase, key enzymes involved in the breakdown and intestinal absorption of carbohydrates.	Carbohydrates	215-228	sucrase-isomaltase	Homo sapiens	129-146
28832912-7	2018	Dried blood spot (DBS) test was used to analyze the activity of the enzyme alpha-glucosidase.	dbs	18-21	sucrase-isomaltase	Homo sapiens	75-92
29112434-0	2017	N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of alpha-Glucosidase Activity for the Treatment of Pompe Disease.	n-butyl-l-deoxynojirimycin	0-26	sucrase-isomaltase	Homo sapiens	77-94
29846922-5	2018	Herein we report a method for carrying out a reverse chemical genetic screen on alpha-glucosidase, the enzyme that catalyzes the final step in starch degradation during plant germination, namely the hydrolysis of maltose to release glucose.	Starch	143-149	sucrase-isomaltase	Homo sapiens	80-97
29846922-5	2018	Herein we report a method for carrying out a reverse chemical genetic screen on alpha-glucosidase, the enzyme that catalyzes the final step in starch degradation during plant germination, namely the hydrolysis of maltose to release glucose.	Maltose	213-220	sucrase-isomaltase	Homo sapiens	80-97
29846922-5	2018	Herein we report a method for carrying out a reverse chemical genetic screen on alpha-glucosidase, the enzyme that catalyzes the final step in starch degradation during plant germination, namely the hydrolysis of maltose to release glucose.	Glucose	232-239	sucrase-isomaltase	Homo sapiens	80-97
29846922-6	2018	This chapter outlines the use of a high-throughput screen of small molecules for inhibition of alpha-glucosidase using a colorimetric assay which involves the substrate p-nitrophenyl alpha-D-glucopyranoside.	4-nitrophenyl alpha-glucoside	169-206	sucrase-isomaltase	Homo sapiens	95-112
28010166-0	2018	Reappraisal and perspectives of clinical drug-drug interaction potential of alpha-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus.	Acarbose	113-121	sucrase-isomaltase	Homo sapiens	76-93
28010166-0	2018	Reappraisal and perspectives of clinical drug-drug interaction potential of alpha-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus.	voglibose	123-132	sucrase-isomaltase	Homo sapiens	76-93
28010166-0	2018	Reappraisal and perspectives of clinical drug-drug interaction potential of alpha-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus.	miglitol	137-145	sucrase-isomaltase	Homo sapiens	76-93
29112434-0	2017	N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of alpha-Glucosidase Activity for the Treatment of Pompe Disease.	l-nbdnj	28-35	sucrase-isomaltase	Homo sapiens	77-94
29195935-3	2017	After digestion, contents of polyphenol, polysaccharide and their antioxidant activity, the inhibitory activity of alpha-amylase and alpha-glucosidase significantly increased.	Polyphenols	29-39	sucrase-isomaltase	Homo sapiens	133-150
28926784-0	2017	Synthesis of thiobarbituric acid derivatives: In vitro alpha-glucosidase inhibition and molecular docking studies.	thiobarbituric acid	13-32	sucrase-isomaltase	Homo sapiens	55-72
28926784-1	2017	Synthesis, structure, and evaluation of in vitro alpha-glucosidase enzyme inhibition of a new class of diethylammonium salts of aryl substituted thiobarbituric acid is described.	diethylammonium salts	103-124	sucrase-isomaltase	Homo sapiens	49-66
28926784-1	2017	Synthesis, structure, and evaluation of in vitro alpha-glucosidase enzyme inhibition of a new class of diethylammonium salts of aryl substituted thiobarbituric acid is described.	aryl substituted thiobarbituric acid	128-164	sucrase-isomaltase	Homo sapiens	49-66
28926784-7	2017	To the best of knowledge this is the first report of the in vitro alpha-glucosidase enzyme inhibition by the diethylamonium salts of aryl substituted thiobarbituric acid.	diethylamonium salts	109-129	sucrase-isomaltase	Homo sapiens	66-83
28926784-7	2017	To the best of knowledge this is the first report of the in vitro alpha-glucosidase enzyme inhibition by the diethylamonium salts of aryl substituted thiobarbituric acid.	aryl substituted thiobarbituric acid	133-169	sucrase-isomaltase	Homo sapiens	66-83
29195935-3	2017	After digestion, contents of polyphenol, polysaccharide and their antioxidant activity, the inhibitory activity of alpha-amylase and alpha-glucosidase significantly increased.	Polysaccharides	41-55	sucrase-isomaltase	Homo sapiens	133-150
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Phenols	82-89	sucrase-isomaltase	Homo sapiens	202-219
28856929-0	2017	New quinoxalinone inhibitors targeting secreted phospholipase A2 and alpha-glucosidase.	3-(1-(phenylhydrazono)-2,3,4-trihydroxybut-1-yl)quinoxalin-2-(1H)-one	4-17	sucrase-isomaltase	Homo sapiens	69-86
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	chrysin	15-22	sucrase-isomaltase	Homo sapiens	202-219
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	carvacrol	24-33	sucrase-isomaltase	Homo sapiens	202-219
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Hesperidin	35-45	sucrase-isomaltase	Homo sapiens	202-219
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	zingerone	47-56	sucrase-isomaltase	Homo sapiens	202-219
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	sucrase-isomaltase	Homo sapiens	202-219
28100083-0	2017	alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives.	Cyclic Urea	68-79	sucrase-isomaltase	Homo sapiens	0-17
28100083-0	2017	alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives.	Carbamates	84-93	sucrase-isomaltase	Homo sapiens	0-17
28100083-1	2017	The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study.	Cyclic Urea	38-49	sucrase-isomaltase	Homo sapiens	90-107
28100083-1	2017	The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study.	Cyclic Urea	38-49	sucrase-isomaltase	Homo sapiens	109-118
28100083-1	2017	The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study.	Carbamates	54-63	sucrase-isomaltase	Homo sapiens	90-107
28100083-1	2017	The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study.	Carbamates	54-63	sucrase-isomaltase	Homo sapiens	109-118
28100083-2	2017	All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose.	Acarbose	121-129	sucrase-isomaltase	Homo sapiens	72-81
28933564-0	2017	alpha-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study.	Flavonoids	32-42	sucrase-isomaltase	Homo sapiens	0-17
28933564-2	2017	As flavonoids are promising modulators of this enzyme"s activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of alpha-glucosidase, based on in vitro structure-activity relationship studies.	Flavonoids	3-13	sucrase-isomaltase	Homo sapiens	164-181
28933564-2	2017	As flavonoids are promising modulators of this enzyme"s activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of alpha-glucosidase, based on in vitro structure-activity relationship studies.	Flavonoids	80-90	sucrase-isomaltase	Homo sapiens	164-181
28933564-4	2017	A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed alpha-glucosidase inhibitor, acarbose.	Flavonoids	2-11	sucrase-isomaltase	Homo sapiens	195-212
29376263-0	2017	[Interaction between gomizine D and alpha-glucosidase].	gomizine d	21-31	sucrase-isomaltase	Homo sapiens	36-53
28933564-4	2017	A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed alpha-glucosidase inhibitor, acarbose.	catechol	21-29	sucrase-isomaltase	Homo sapiens	195-212
28933564-4	2017	A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed alpha-glucosidase inhibitor, acarbose.	Acarbose	224-232	sucrase-isomaltase	Homo sapiens	195-212
28100083-6	2017	Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs.	cyclic ureas	0-12	sucrase-isomaltase	Homo sapiens	50-67
28100083-6	2017	Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs.	Carbamates	17-27	sucrase-isomaltase	Homo sapiens	50-67
29376263-1	2017	This paper describes a study exploring the interaction between gomizine D and alpha-glucosidase.	gomizine d	63-73	sucrase-isomaltase	Homo sapiens	78-95
29376263-2	2017	The inhibitory activity of alpha-glucosidase by gomizine D was determined using PNPG as substrates Gomizine D gave the IC50 value of 0.59 mmol L-1, which was higher than that of acarbose (1.95 mmol L-1).	gomizine d	48-58	sucrase-isomaltase	Homo sapiens	27-44
29376263-2	2017	The inhibitory activity of alpha-glucosidase by gomizine D was determined using PNPG as substrates Gomizine D gave the IC50 value of 0.59 mmol L-1, which was higher than that of acarbose (1.95 mmol L-1).	4-nitrophenylgalactoside	80-84	sucrase-isomaltase	Homo sapiens	27-44
29376263-2	2017	The inhibitory activity of alpha-glucosidase by gomizine D was determined using PNPG as substrates Gomizine D gave the IC50 value of 0.59 mmol L-1, which was higher than that of acarbose (1.95 mmol L-1).	gomizine d	99-109	sucrase-isomaltase	Homo sapiens	27-44
29376263-2	2017	The inhibitory activity of alpha-glucosidase by gomizine D was determined using PNPG as substrates Gomizine D gave the IC50 value of 0.59 mmol L-1, which was higher than that of acarbose (1.95 mmol L-1).	Acarbose	178-186	sucrase-isomaltase	Homo sapiens	27-44
29376263-4	2017	The binding mode between gomizine D and alpha-glucosidase was analyzed by AutoDock Vina molecular docking software.	gomizine d	25-35	sucrase-isomaltase	Homo sapiens	40-57
29376263-5	2017	The lowest energy of Gomizine D binding to alpha-glucosidase was -7.7 kcal mol-1, which was lower than that of acarbose (-6.6 kcal mol-1).	gomizine d	21-31	sucrase-isomaltase	Homo sapiens	43-60
29376263-6	2017	After binding with gomizine D, UV spectroscopy analysis displayed that the microenvironment of aromatic residue in the secondary structure of alpha-glucosidase was changed, and the polarity of protein was reduced.	gomizine d	19-29	sucrase-isomaltase	Homo sapiens	142-159
26854322-4	2017	As such, when the presence of alpha-glucosidase inhibitor in many foodstuffs was screened for, we found that vegetable seed oil also strongly inhibited alpha-glucosidase and alpha-amylase.	seed oil	119-127	sucrase-isomaltase	Homo sapiens	152-169
28964635-0	2017	Pentacyclic triterpenes as alpha-glucosidase and alpha-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.	pentacyclic	0-11	sucrase-isomaltase	Homo sapiens	27-44
28964635-0	2017	Pentacyclic triterpenes as alpha-glucosidase and alpha-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.	Triterpenes	12-23	sucrase-isomaltase	Homo sapiens	27-44
28964635-0	2017	Pentacyclic triterpenes as alpha-glucosidase and alpha-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.	Acarbose	131-139	sucrase-isomaltase	Homo sapiens	27-44
28964635-1	2017	In this paper, the inhibition of alpha-amylase and alpha-glucosidase by nine pentacyclic triterpenes was determined.	Triterpenes	89-100	sucrase-isomaltase	Homo sapiens	51-68
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	ursolic acid	53-65	sucrase-isomaltase	Homo sapiens	4-21
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	corosolic acid	67-81	sucrase-isomaltase	Homo sapiens	4-21
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	betulinic acid	83-97	sucrase-isomaltase	Homo sapiens	4-21
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	Oleanolic Acid	103-117	sucrase-isomaltase	Homo sapiens	4-21
28964635-5	2017	The combination of the tested triterpenes with acarbose mainly exhibited additive inhibition against alpha-glucosidase.	Triterpenes	30-41	sucrase-isomaltase	Homo sapiens	101-118
28964635-5	2017	The combination of the tested triterpenes with acarbose mainly exhibited additive inhibition against alpha-glucosidase.	Acarbose	47-55	sucrase-isomaltase	Homo sapiens	101-118
26854322-0	2017	alpha-Glucosidase and alpha-amylase inhibitors from seed oil: A review of liposoluble substance to treat diabetes.	seed oil	52-60	sucrase-isomaltase	Homo sapiens	0-17
26854322-1	2017	One of the effective managements of diabetes mellitus, in particular, noninsulin-dependent diabetes mellitus, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as alpha-glucosidase and alpha-amylase, in the digestive organs.	Glucose	141-148	sucrase-isomaltase	Homo sapiens	208-225
26854322-1	2017	One of the effective managements of diabetes mellitus, in particular, noninsulin-dependent diabetes mellitus, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as alpha-glucosidase and alpha-amylase, in the digestive organs.	Carbohydrates	166-178	sucrase-isomaltase	Homo sapiens	208-225
26854322-4	2017	As such, when the presence of alpha-glucosidase inhibitor in many foodstuffs was screened for, we found that vegetable seed oil also strongly inhibited alpha-glucosidase and alpha-amylase.	seed oil	119-127	sucrase-isomaltase	Homo sapiens	30-47
29027136-2	2017	In a previous study, we demonstrated oligonol inhibits PTP1B and alpha-glucosidase related to T2DM.	oligonol	37-45	sucrase-isomaltase	Homo sapiens	65-82
29084182-0	2017	Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as alpha-Glucosidase Inhibitors.	2-substituted-4,6-diarylpyrimidines	64-99	sucrase-isomaltase	Homo sapiens	103-120
28551221-2	2017	Results showed that, with increasing extraction temperature, the polyphenol content increased, which contributed to enhance antioxidant activity and inhibitory effects on alpha-glucosidase and alpha-amylase.	Polyphenols	65-75	sucrase-isomaltase	Homo sapiens	171-188
30023541-3	2017	Out of 16 new spiro-iminosugars, the spiro-iminosugars 3a (IC50 = 0.075 muM) and 4a (IC50 = 0.036 muM) were found to be more potent inhibitors of alpha-glucosidase than the marketed drug miglitol (IC50 = 0.100 muM).	spiro-iminosugars	14-31	sucrase-isomaltase	Homo sapiens	146-163
30023541-3	2017	Out of 16 new spiro-iminosugars, the spiro-iminosugars 3a (IC50 = 0.075 muM) and 4a (IC50 = 0.036 muM) were found to be more potent inhibitors of alpha-glucosidase than the marketed drug miglitol (IC50 = 0.100 muM).	spiro-iminosugars	37-54	sucrase-isomaltase	Homo sapiens	146-163
30023541-5	2017	In few cases, the N-alkyl derivatives showed increase of alpha-glucosidase inhibition and enhancement of antifungal activity compare to the respective parent iminosugar.	Nitrogen	18-19	sucrase-isomaltase	Homo sapiens	57-74
29084182-1	2017	A novel series of 2-substituted-4,6-diarylpyrimidines 6a-6t has been synthesized, characterized by 1H-NMR, 13C-NMR and HRMS, and screened for in vitro alpha-glucosidase inhibitory activity.	2-substituted-4,6-diarylpyrimidines	18-53	sucrase-isomaltase	Homo sapiens	151-168
29084182-2	2017	The majority of the screened compounds possessed significant alpha-glucosidase inhibitory activity with IC50 values ranging from 19.6 +- 0.21 to 38.9 +- 0.35 muM, which is more potent than the positive control alpha-glucosidase inhibitor acarbose (IC50 = 817.38 +- 6.27 muM).	Acarbose	238-246	sucrase-isomaltase	Homo sapiens	61-78
29084182-2	2017	The majority of the screened compounds possessed significant alpha-glucosidase inhibitory activity with IC50 values ranging from 19.6 +- 0.21 to 38.9 +- 0.35 muM, which is more potent than the positive control alpha-glucosidase inhibitor acarbose (IC50 = 817.38 +- 6.27 muM).	Acarbose	238-246	sucrase-isomaltase	Homo sapiens	210-227
29084182-4	2017	In addition, molecular docking studies were carried out to explore the binding interactions of 2-substituted-4,6-diarylpyrimidine derivatives with alpha-glucosidase.	2-substituted-4,6-diarylpyrimidine	95-129	sucrase-isomaltase	Homo sapiens	147-164
28797772-0	2017	Synthesis of novel flavonoid alkaloids as alpha-glucosidase inhibitors.	flavonoid alkaloids	19-38	sucrase-isomaltase	Homo sapiens	42-59
28780468-0	2017	Design and synthesis of 2,6-di(substituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as alpha-glucosidase and alpha-amylase inhibitors, co-relative Pharmacokinetics and 3D QSAR and risk analysis.	2,6-di(substituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles	24-81	sucrase-isomaltase	Homo sapiens	85-102
28750203-1	2017	Discovery of alpha-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of type-II diabetes mellitus and the other carbohydrate mediated disease.	Carbohydrates	166-178	sucrase-isomaltase	Homo sapiens	13-30
28750203-4	2017	All compounds were evaluated for alpha-glucosidase inhibiting potential and showed potent inhibitory activity in the range of IC50=2.00+-0.01-292.40+-3.16muM as compared to standard acarbose (IC50=895.09+-2.04microM).	Acarbose	182-190	sucrase-isomaltase	Homo sapiens	33-50
28539267-0	2017	Computational prediction integrating the inhibition kinetics of gallotannin on alpha-glucosidase.	Hydrolyzable Tannins	64-75	sucrase-isomaltase	Homo sapiens	79-96
28665538-0	2017	alpha-Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca.	Xanthones	29-38	sucrase-isomaltase	Homo sapiens	0-17
28539267-3	2017	In this study, we performed a computational docking experiment involving the pre-simulation of the binding mechanism of GT, and the effect of GT on alpha-glucosidase was evaluated with inhibitory kinetics based on its polyphenol properties.	Polyphenols	218-228	sucrase-isomaltase	Homo sapiens	148-165
28875706-0	2017	Dietary Flavonoids and Acarbose Synergistically Inhibit alpha-Glucosidase and Lower Postprandial Blood Glucose.	Flavonoids	8-18	sucrase-isomaltase	Homo sapiens	56-73
29243417-2	2017	Andrographolide and its derivatives are proved to posses a wide range of biological activities, such as anti-inflammatory, antiviral, anti-tumor, anti-human immunodeficiency virus(HIV), hepatoprotective and alpha-glucosidase inhibition activity.	andrographolide	0-15	sucrase-isomaltase	Homo sapiens	207-224
28672278-0	2017	Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro alpha-glucosidase inhibitory activity, and in silico studies.	hydrazinyl arylthiazole	0-23	sucrase-isomaltase	Homo sapiens	99-116
28672278-0	2017	Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro alpha-glucosidase inhibitory activity, and in silico studies.	pyridine	30-38	sucrase-isomaltase	Homo sapiens	99-116
28672278-1	2017	Acarbose, miglitol, and voglibose are the inhibitors of alpha-glucosidase enzyme and being clinically used for the management of type-II diabetes mellitus.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	56-73
28672278-1	2017	Acarbose, miglitol, and voglibose are the inhibitors of alpha-glucosidase enzyme and being clinically used for the management of type-II diabetes mellitus.	miglitol	10-18	sucrase-isomaltase	Homo sapiens	56-73
28672278-1	2017	Acarbose, miglitol, and voglibose are the inhibitors of alpha-glucosidase enzyme and being clinically used for the management of type-II diabetes mellitus.	voglibose	24-33	sucrase-isomaltase	Homo sapiens	56-73
28875706-1	2017	The inhibition of porcine pancreatic alpha-amylase and mammalian alpha-glucosidase by 16 individual flavonoids was determined.	Flavonoids	100-110	sucrase-isomaltase	Homo sapiens	65-82
28875706-2	2017	The IC50 values for baicalein, (+)-catechin, quercetin, and luteolin were 74.1 +- 5.6, 175.1 +- 9.1, 281.2 +- 19.2, and 339.4 +- 16.3 muM, respectively, against alpha-glucosidase.	baicalein	20-29	sucrase-isomaltase	Homo sapiens	161-178
28875706-2	2017	The IC50 values for baicalein, (+)-catechin, quercetin, and luteolin were 74.1 +- 5.6, 175.1 +- 9.1, 281.2 +- 19.2, and 339.4 +- 16.3 muM, respectively, against alpha-glucosidase.	Luteolin	60-68	sucrase-isomaltase	Homo sapiens	161-178
28875706-0	2017	Dietary Flavonoids and Acarbose Synergistically Inhibit alpha-Glucosidase and Lower Postprandial Blood Glucose.	Acarbose	23-31	sucrase-isomaltase	Homo sapiens	56-73
28875706-4	2017	The combination of baicalein, quercetin, or luteolin with acarbose showed synergistic inhibition, and the combination of (+)-catechin with acarbose showed antagonistic inhibition of alpha-glucosidase.	Catechin	121-133	sucrase-isomaltase	Homo sapiens	182-199
28875706-4	2017	The combination of baicalein, quercetin, or luteolin with acarbose showed synergistic inhibition, and the combination of (+)-catechin with acarbose showed antagonistic inhibition of alpha-glucosidase.	Acarbose	139-147	sucrase-isomaltase	Homo sapiens	182-199
28875706-6	2017	Kinetic studies of alpha-glucosidase activity revealed that baicalein alone, acarbose alone, and the combination showed noncompetitive, competitive, and mixed-type inhibition, respectively.	baicalein	60-69	sucrase-isomaltase	Homo sapiens	19-36
28875706-6	2017	Kinetic studies of alpha-glucosidase activity revealed that baicalein alone, acarbose alone, and the combination showed noncompetitive, competitive, and mixed-type inhibition, respectively.	Acarbose	77-85	sucrase-isomaltase	Homo sapiens	19-36
28838691-0	2017	Quinazoline-1-deoxynojirimycin hybrids as high active dual inhibitors of EGFR and alpha-glucosidase.	quinazoline-1-deoxynojirimycin	0-30	sucrase-isomaltase	Homo sapiens	82-99
28838691-1	2017	A series of novel quinazoline-1-deoxynojirimycin hybrids were designed, synthesized and evaluated for their inhibitory activities against two drug target enzymes, epidermal growth factor receptor (EGFR) tyrosine kinase and alpha-glucosidase.	quinazoline-1-deoxynojirimycin	18-48	sucrase-isomaltase	Homo sapiens	223-240
28752763-2	2017	Evaluated as glycoside hydrolase inhibitors, these quinolizidines revealed to be potent and selective alpha-glucosidase inhibitors.	Quinolizidines	51-65	sucrase-isomaltase	Homo sapiens	102-119
28747001-0	2017	Novel thiosemicarbazide derivatives with 4-nitrophenyl group as multi-target drugs: alpha-glucosidase inhibitors with antibacterial and antiproliferative activity.	thiosemicarbazide	6-23	sucrase-isomaltase	Homo sapiens	84-101
28570943-0	2017	alpha-Glucosidase inhibitory effect of resveratrol and piceatannol.	Resveratrol	39-50	sucrase-isomaltase	Homo sapiens	0-17
28781158-0	2017	Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of alpha-glucosidase inhibition.	nitro-substituted tetrahydroindolizines	0-39	sucrase-isomaltase	Homo sapiens	89-106
28781158-1	2017	A series of 1-[(methylsulfonyl)methyl]-2-nitro-5,6,7,8-tetrahydroindolizines and homologs were designed, prepared, and evaluated as non-sugar-type alpha-glucosidase inhibitors.	1-[(methylsulfonyl)methyl]-2-nitro-5,6,7,8-tetrahydroindolizines	12-76	sucrase-isomaltase	Homo sapiens	147-164
28781158-7	2017	Considering the relatively low molecular weight of 3e together with its high fraction of sp3 hybridized carbon atoms, this nitro-substituted tetrahydroindolizine may be considered as a good starting point towards new leads in the area of alpha-glucosidase inhibitors.	tetrahydroindolizine	141-161	sucrase-isomaltase	Homo sapiens	238-255
27555333-0	2017	alpha-Glucosidase inhibitory activity, molecular docking, QSAR and ADMET properties of novel 2-amino-phenyldiazenyl-4H-chromene derivatives.	2-amino-phenyldiazenyl-4h-chromene	93-127	sucrase-isomaltase	Homo sapiens	0-17
28570943-0	2017	alpha-Glucosidase inhibitory effect of resveratrol and piceatannol.	3,3',4,5'-tetrahydroxystilbene	55-66	sucrase-isomaltase	Homo sapiens	0-17
28570943-1	2017	Dietary polyphenols have been shown to inhibit alpha-glucosidase, an enzyme target of some antidiabetic drugs.	Polyphenols	8-19	sucrase-isomaltase	Homo sapiens	47-64
28570943-2	2017	Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast alpha-glucosidase.	Resveratrol	0-11	sucrase-isomaltase	Homo sapiens	103-120
28570943-2	2017	Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast alpha-glucosidase.	Polyphenols	15-25	sucrase-isomaltase	Homo sapiens	103-120
28570943-4	2017	Using either sucrose or maltose as substrate resveratrol, piceatannol and 3"-hydroxypterostilbene showed strong inhibition of mammalian alpha-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition.	Sucrose	13-20	sucrase-isomaltase	Homo sapiens	136-153
28570943-4	2017	Using either sucrose or maltose as substrate resveratrol, piceatannol and 3"-hydroxypterostilbene showed strong inhibition of mammalian alpha-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition.	Maltose	24-31	sucrase-isomaltase	Homo sapiens	136-153
28570943-4	2017	Using either sucrose or maltose as substrate resveratrol, piceatannol and 3"-hydroxypterostilbene showed strong inhibition of mammalian alpha-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition.	Resveratrol	45-56	sucrase-isomaltase	Homo sapiens	136-153
28570943-4	2017	Using either sucrose or maltose as substrate resveratrol, piceatannol and 3"-hydroxypterostilbene showed strong inhibition of mammalian alpha-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition.	3,3',4,5'-tetrahydroxystilbene	58-69	sucrase-isomaltase	Homo sapiens	136-153
28570943-4	2017	Using either sucrose or maltose as substrate resveratrol, piceatannol and 3"-hydroxypterostilbene showed strong inhibition of mammalian alpha-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition.	3'-hydroxypterostilbene	74-97	sucrase-isomaltase	Homo sapiens	136-153
28570943-4	2017	Using either sucrose or maltose as substrate resveratrol, piceatannol and 3"-hydroxypterostilbene showed strong inhibition of mammalian alpha-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition.	trans-desoxyrhapontigenin	206-231	sucrase-isomaltase	Homo sapiens	136-153
28570943-5	2017	Compared to acarbose (IC50 3-13 mug/ml), piceatannol and resveratrol inhibited mammalian alpha-glucosidase to a lesser extent (IC50 14-84 and 111-120 mug/ml, respectively).	3,3',4,5'-tetrahydroxystilbene	41-52	sucrase-isomaltase	Homo sapiens	89-106
28570943-5	2017	Compared to acarbose (IC50 3-13 mug/ml), piceatannol and resveratrol inhibited mammalian alpha-glucosidase to a lesser extent (IC50 14-84 and 111-120 mug/ml, respectively).	Resveratrol	57-68	sucrase-isomaltase	Homo sapiens	89-106
28570943-9	2017	Our studies demonstrate that the dietary polyphenols resveratrol and piceatannol lower postprandial hyperglycemia and indicate that inhibition of intestinal alpha-glucosidase activity may be a potential mechanism contributing to their antidiabetic property.	Resveratrol	53-64	sucrase-isomaltase	Homo sapiens	157-174
28861624-1	2017	Recently, a series of xanthone analogues has been identified as alpha-glucosidase inhibitors.	xanthone	22-30	sucrase-isomaltase	Homo sapiens	64-81
28861624-0	2017	Docking-assisted 3D-QSAR studies on xanthones as alpha-glucosidase inhibitors.	Xanthones	36-45	sucrase-isomaltase	Homo sapiens	49-66
28855825-5	2017	Inhibition of alpha-amylase and alpha-glucosidase enzymes retards the rate of carbohydrate digestion, thereby provides an alternative and a less evasive strategy of reducing postprandial hyperglycaemia in diabetic patients.	Carbohydrates	78-90	sucrase-isomaltase	Homo sapiens	32-49
28745879-5	2017	The quercetin treated with the plasma for 20 min showed rapidly increased alpha-glucosidase inhibitory and radical scavenging activities compared to those of parent quercetin.	Quercetin	4-13	sucrase-isomaltase	Homo sapiens	74-91
28850567-6	2017	An alpha-glucosidase inhibitor (acarbose) was added to all test stimuli to prevent oral digestion of glucose oligomers.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	3-20
28651984-1	2017	A series of 6-hydroxyaurones and their analogues have been synthesized and evaluated for their in vitro alpha-glucosidase inhibitory and glucose consumption-promoting activity.	6-hydroxyaurones	12-28	sucrase-isomaltase	Homo sapiens	104-121
28521172-0	2017	Hetarylcoumarins: Synthesis and biological evaluation as potent alpha-glucosidase inhibitors.	hetarylcoumarins	0-16	sucrase-isomaltase	Homo sapiens	64-81
28521172-1	2017	In search of better alpha-glucosidase inhibitors, a series of novel hetarylcoumarins (3a-3j) were designed and synthesized through a facile multicomponent route where p-toluenesulfonic acid (PTSA) was explored as an efficient catalyst.	hetarylcoumarins	68-84	sucrase-isomaltase	Homo sapiens	20-37
28521172-1	2017	In search of better alpha-glucosidase inhibitors, a series of novel hetarylcoumarins (3a-3j) were designed and synthesized through a facile multicomponent route where p-toluenesulfonic acid (PTSA) was explored as an efficient catalyst.	4-toluenesulfonic acid	167-189	sucrase-isomaltase	Homo sapiens	20-37
28372224-7	2017	Anthocyanin-rich extracts inhibited alpha-glucosidase (37.8%), alpha-amylase (35.6%), dipeptidyl peptidase-IV (34.4%), reactive oxygen species (81.6%), and decreased glucose uptake.	Anthocyanins	0-11	sucrase-isomaltase	Homo sapiens	36-53
28651984-0	2017	Synthesis of 6-hydroxyaurone analogues and evaluation of their alpha-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives.	6-hydroxyaurone	13-28	sucrase-isomaltase	Homo sapiens	63-80
28651984-2	2017	These compounds exhibited varying degrees of alpha-glucosidase inhibitory activity, 11 of them showing higher potency than that of the control standard acarbose (IC50=50.30muM).	Acarbose	152-160	sucrase-isomaltase	Homo sapiens	45-62
28745380-7	2017	Furthermore, this natural oil, owing to its rich phytochemical profile, showed relevant antioxidant activity (especially in lipid peroxidation inhibition assays), alpha-glucosidase inhibitory activity, cytotoxicity against human tumour cell lines, antibacterial (mainly against Gram positive species) and antifungal properties, as well as anti-inflammatory and analgesic activities.	Oils	26-29	sucrase-isomaltase	Homo sapiens	163-180
28322965-0	2017	Inhibitory effect of hesperetin on alpha-glucosidase: Molecular dynamics simulation integrating inhibition kinetics.	hesperetin	21-31	sucrase-isomaltase	Homo sapiens	35-52
28322965-3	2017	This paper presents an evaluation on the effects of hesperetin on alpha-glucosidase via inhibitory kinetics using a Molecular Dynamics (MD) simulation integration method.	hesperetin	52-62	sucrase-isomaltase	Homo sapiens	66-83
28322965-4	2017	Due to the antioxidant properties of hesperetin, it reversibly inhibits alpha-glucosidase in a slope-parabolic mixed-type manner (IC50=0.38+-0.05mM; Kslope=0.23+-0.01mM), accompanied by tertiary structural changes.	hesperetin	37-47	sucrase-isomaltase	Homo sapiens	72-89
28322965-5	2017	Based on computational MD and docking simulations, two hesperetin rings interact with several residues near the active site on the alpha-glucosidase, such as Lys155, Asn241, Glu304, Pro309, Phe311 and Arg312.	hesperetin	55-65	sucrase-isomaltase	Homo sapiens	131-148
28322965-6	2017	This study provides insight into the inhibition of alpha-glucosidase by binding hesperetin onto active site residues and accompanying structural changes.	hesperetin	80-90	sucrase-isomaltase	Homo sapiens	51-68
28322965-7	2017	Hesperetin presents as a potential agent for treating alpha-glucosidase-associated type-2 diabetes based on its alpha-glucosidase-inhibiting effect and its potential as a natural antioxidant.	hesperetin	0-10	sucrase-isomaltase	Homo sapiens	54-71
28322965-7	2017	Hesperetin presents as a potential agent for treating alpha-glucosidase-associated type-2 diabetes based on its alpha-glucosidase-inhibiting effect and its potential as a natural antioxidant.	hesperetin	0-10	sucrase-isomaltase	Homo sapiens	112-129
28776021-5	2017	We show that 1,6-epi-cyclophellitol cyclosulfate (alpha-cyclosulfate) is a rapidly reacting alpha-glucosidase inhibitor whose 4C1 chair conformation matches that adopted by alpha-glucosidase Michaelis complexes.	1,6-epi-cyclophellitol cyclosulfate	13-48	sucrase-isomaltase	Homo sapiens	92-109
28267073-3	2017	Six enzyme activities, 2 alpha-amylases (Amy), and 4 mucosal alpha-glucosidases (maltases), including maltase-glucoamylase (Mgam) and sucrase-isomaltase (Si) subunit activities, are needed to digest starch to absorbable free glucose.	Starch	199-205	sucrase-isomaltase	Homo sapiens	134-152
28267073-3	2017	Six enzyme activities, 2 alpha-amylases (Amy), and 4 mucosal alpha-glucosidases (maltases), including maltase-glucoamylase (Mgam) and sucrase-isomaltase (Si) subunit activities, are needed to digest starch to absorbable free glucose.	Starch	199-205	sucrase-isomaltase	Homo sapiens	0-2
28267073-3	2017	Six enzyme activities, 2 alpha-amylases (Amy), and 4 mucosal alpha-glucosidases (maltases), including maltase-glucoamylase (Mgam) and sucrase-isomaltase (Si) subunit activities, are needed to digest starch to absorbable free glucose.	Glucose	225-232	sucrase-isomaltase	Homo sapiens	134-152
28267073-3	2017	Six enzyme activities, 2 alpha-amylases (Amy), and 4 mucosal alpha-glucosidases (maltases), including maltase-glucoamylase (Mgam) and sucrase-isomaltase (Si) subunit activities, are needed to digest starch to absorbable free glucose.	Glucose	225-232	sucrase-isomaltase	Homo sapiens	0-2
28267073-4	2017	Amy breaks down insoluble starch to soluble dextrins; mucosal Mgam and Si can either directly digest starch to glucose or convert the post-alpha-amylolytic dextrins to glucose.	Starch	101-107	sucrase-isomaltase	Homo sapiens	71-73
28267073-4	2017	Amy breaks down insoluble starch to soluble dextrins; mucosal Mgam and Si can either directly digest starch to glucose or convert the post-alpha-amylolytic dextrins to glucose.	Glucose	111-118	sucrase-isomaltase	Homo sapiens	71-73
28267073-4	2017	Amy breaks down insoluble starch to soluble dextrins; mucosal Mgam and Si can either directly digest starch to glucose or convert the post-alpha-amylolytic dextrins to glucose.	Dextrins	156-164	sucrase-isomaltase	Homo sapiens	71-73
28267073-4	2017	Amy breaks down insoluble starch to soluble dextrins; mucosal Mgam and Si can either directly digest starch to glucose or convert the post-alpha-amylolytic dextrins to glucose.	Glucose	168-175	sucrase-isomaltase	Homo sapiens	71-73
28776021-5	2017	We show that 1,6-epi-cyclophellitol cyclosulfate (alpha-cyclosulfate) is a rapidly reacting alpha-glucosidase inhibitor whose 4C1 chair conformation matches that adopted by alpha-glucosidase Michaelis complexes.	1,6-epi-cyclophellitol cyclosulfate	13-48	sucrase-isomaltase	Homo sapiens	173-190
28776021-5	2017	We show that 1,6-epi-cyclophellitol cyclosulfate (alpha-cyclosulfate) is a rapidly reacting alpha-glucosidase inhibitor whose 4C1 chair conformation matches that adopted by alpha-glucosidase Michaelis complexes.	alpha-cyclosulfate	50-68	sucrase-isomaltase	Homo sapiens	92-109
28776021-5	2017	We show that 1,6-epi-cyclophellitol cyclosulfate (alpha-cyclosulfate) is a rapidly reacting alpha-glucosidase inhibitor whose 4C1 chair conformation matches that adopted by alpha-glucosidase Michaelis complexes.	alpha-cyclosulfate	50-68	sucrase-isomaltase	Homo sapiens	173-190
28683829-0	2017	alpha-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study.	Glucose	48-55	sucrase-isomaltase	Homo sapiens	0-17
28677657-1	2017	This study assessed the in vitro effects of the bioaccessible food components released during the simulated human digestion of a coffee fibre-containing biscuit (CFB) on alpha-glucosidase activity, antioxidant capacity and satiety hormones.	coffee fibre	129-141	sucrase-isomaltase	Homo sapiens	170-187
28506754-0	2017	Synthesis, biological evaluation and molecular docking studies of chromone hydrazone derivatives as alpha-glucosidase inhibitors.	chromone hydrazone	66-84	sucrase-isomaltase	Homo sapiens	100-117
28506754-1	2017	A series of chromone hydrazone derivatives 4a-4p have been synthesized, characterized by 1H NMR and 13C NMR and evaluated for theirinvitro alpha-glucosidase inhibitory activity.	chromone hydrazone	12-30	sucrase-isomaltase	Homo sapiens	139-156
28506754-2	2017	Out of these tested compounds, six (4a, 4b, 4d, 4j, 4o and 4p) displayed potent alpha-glucosidase inhibitory activity with IC50 values in the range of 20.1+-0.19muM to 45.7+-0.23muM, as compared to the standard drug acarbose (IC50=817.38+-6.27muM).	Acarbose	216-224	sucrase-isomaltase	Homo sapiens	80-97
28506754-7	2017	In summary, our studies shown that these chromone hydrazone derivatives are a new class of alpha-glucosidase inhibitors.	chromone hydrazone	41-59	sucrase-isomaltase	Homo sapiens	91-108
28979070-2	2017	One of the effective therapeutic managements of the disease is to reduce postprandial hyperglycemia through inhibition of alpha-glucosidase, a carbohydrate-hydrolyzing enzyme to retard overall glucose absorption.	Carbohydrates	143-155	sucrase-isomaltase	Homo sapiens	122-139
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Flavonoids	52-62	sucrase-isomaltase	Homo sapiens	184-201
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Alkaloids	64-73	sucrase-isomaltase	Homo sapiens	184-201
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Terpenes	75-85	sucrase-isomaltase	Homo sapiens	184-201
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Anthocyanins	87-99	sucrase-isomaltase	Homo sapiens	184-201
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Glycosides	101-111	sucrase-isomaltase	Homo sapiens	184-201
28522605-1	2017	Sucrase-isomaltase (SI) is an intestinal membrane-associated alpha-glucosidase that breaks down di- and oligosaccharides to absorbable monosaccharides.	Monosaccharides	135-150	sucrase-isomaltase	Homo sapiens	0-18
28522605-1	2017	Sucrase-isomaltase (SI) is an intestinal membrane-associated alpha-glucosidase that breaks down di- and oligosaccharides to absorbable monosaccharides.	Monosaccharides	135-150	sucrase-isomaltase	Homo sapiens	61-78
28522605-1	2017	Sucrase-isomaltase (SI) is an intestinal membrane-associated alpha-glucosidase that breaks down di- and oligosaccharides to absorbable monosaccharides.	di- and oligosaccharides	96-120	sucrase-isomaltase	Homo sapiens	0-18
28495082-0	2017	Synthesis and alpha-glucosidase inhibition activity of dihydroxy pyrrolidines.	dihydroxy pyrrolidines	55-77	sucrase-isomaltase	Homo sapiens	14-31
28522605-1	2017	Sucrase-isomaltase (SI) is an intestinal membrane-associated alpha-glucosidase that breaks down di- and oligosaccharides to absorbable monosaccharides.	di- and oligosaccharides	96-120	sucrase-isomaltase	Homo sapiens	61-78
28502432-0	2017	Carbon dots for fluorescent detection of alpha-glucosidase activity using enzyme activated inner filter effect and its application to anti-diabetic drug discovery.	Carbon	0-6	sucrase-isomaltase	Homo sapiens	41-58
28502432-2	2017	In the present study, a facile and sensitive fluorescent assay based on enzyme activated inner filter effect (IFE) on nitrogen-doped carbon dots (CDs) was first developed for the detection of alpha-glucosidase.	Nitrogen	118-126	sucrase-isomaltase	Homo sapiens	192-209
28502432-2	2017	In the present study, a facile and sensitive fluorescent assay based on enzyme activated inner filter effect (IFE) on nitrogen-doped carbon dots (CDs) was first developed for the detection of alpha-glucosidase.	Methane	133-144	sucrase-isomaltase	Homo sapiens	192-209
28502432-2	2017	In the present study, a facile and sensitive fluorescent assay based on enzyme activated inner filter effect (IFE) on nitrogen-doped carbon dots (CDs) was first developed for the detection of alpha-glucosidase.	cds	146-149	sucrase-isomaltase	Homo sapiens	192-209
28502432-4	2017	Through alpha-glucosidase catalysis, 4-nitrophenol was released from 4-nitrophenyl-alpha-d-glucopyranoside (NGP).	4-nitrophenol	37-50	sucrase-isomaltase	Homo sapiens	8-25
28502432-4	2017	Through alpha-glucosidase catalysis, 4-nitrophenol was released from 4-nitrophenyl-alpha-d-glucopyranoside (NGP).	4-nitrophenyl alpha-glucoside	69-106	sucrase-isomaltase	Homo sapiens	8-25
28502432-4	2017	Through alpha-glucosidase catalysis, 4-nitrophenol was released from 4-nitrophenyl-alpha-d-glucopyranoside (NGP).	4-nitrophenyl alpha-glucoside	108-111	sucrase-isomaltase	Homo sapiens	8-25
28502432-7	2017	By converting the absorption signals into fluorescence signals, the facile fluorescence assay strategy could be realized for alpha-glucosidase activity sensing, which effectively avoided the complex modification of the surface of CDs or construction of the nanoprobes.	cds	230-233	sucrase-isomaltase	Homo sapiens	125-142
28502432-10	2017	As a typical alpha-glucosidase inhibitor, acarbose was investigated with a low detection limit of 10-8 M. This developed method enjoyed many merits including simplicity, lost cost, high sensitivity, good reproducibility and excellent selectivity, which also provided a new insight on the application of CDs to develop the facile and sensitive biosensor.	Acarbose	42-50	sucrase-isomaltase	Homo sapiens	13-30
28495082-1	2017	A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,4-dihydroxypyrrolidines as alpha-glucosidase inhibitors were designed and synthesized.	deacetylsarmentamide a	16-38	sucrase-isomaltase	Homo sapiens	114-131
28495082-1	2017	A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,4-dihydroxypyrrolidines as alpha-glucosidase inhibitors were designed and synthesized.	Boron	43-44	sucrase-isomaltase	Homo sapiens	114-131
28495082-1	2017	A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,4-dihydroxypyrrolidines as alpha-glucosidase inhibitors were designed and synthesized.	Sulfonamides	69-81	sucrase-isomaltase	Homo sapiens	114-131
28495082-1	2017	A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,4-dihydroxypyrrolidines as alpha-glucosidase inhibitors were designed and synthesized.	3,4-dihydroxypyrrolidine	85-110	sucrase-isomaltase	Homo sapiens	114-131
28621397-4	2017	Both complexes showed strong enzyme inhibition, i.e., 70% and 90% for alpha-glucosidase with IC50 = 34.6 and 30.1 muM for 1 and 2, respectively, where acarbose was employed as control.	Acarbose	151-159	sucrase-isomaltase	Homo sapiens	70-87
30108873-0	2017	Synthesis, molecular modeling and biological evaluation of aza-flavanones as alpha-glucosidase inhibitors.	aza-flavanones	59-73	sucrase-isomaltase	Homo sapiens	77-94
30108873-1	2017	An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their alpha-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards.	aza-flavanones	85-99	sucrase-isomaltase	Homo sapiens	110-127
30108873-1	2017	An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their alpha-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards.	Acarbose	167-175	sucrase-isomaltase	Homo sapiens	110-127
30108873-1	2017	An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their alpha-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards.	miglitol	177-185	sucrase-isomaltase	Homo sapiens	110-127
30108873-4	2017	This study is the first biological evaluation of aza-flavanones as alpha-glucosidase inhibitors.	aza-flavanones	49-63	sucrase-isomaltase	Homo sapiens	67-84
28704188-13	2017	Methanol and aqueous extracts there were found to be effective inhibitors of alpha-glucosidase with an IC50 value of 20 mug GAE/ml and 55 mug GAE/ml, respectively.	Methanol	0-8	sucrase-isomaltase	Homo sapiens	77-94
28346872-1	2017	On the basis of previous report on promising alpha-glucosidase inhibitory activity of 5-bromo-2-aryl benzimidazole derivatives, these derivatives were further screened for urease inhibitory and cytotoxicity activity in order to get more potent and non-cytotoxic potential dual inhibitor for the patients suffering from diabetes as well as peptic ulcer.	5-bromo-2-aryl benzimidazole	86-114	sucrase-isomaltase	Homo sapiens	45-62
28482263-0	2017	Discovery of 3,3-di(indolyl)indolin-2-one as a novel scaffold for alpha-glucosidase inhibitors: In silico studies and SAR predictions.	3,3-di(indolyl)indolin-2-one	13-41	sucrase-isomaltase	Homo sapiens	66-83
28482263-1	2017	3,3-Di(indolyl)indolin-2-ones 4a-4n were synthesized and evaluated for their in vitro alpha-glucosidase inhibitory activity.	3,3-di(indolyl)indolin-2-ones 4a-4n	0-35	sucrase-isomaltase	Homo sapiens	86-103
28482263-2	2017	These newly synthesized compounds showed moderate to potent alpha-glucosidase inhibitory activity with IC50 range from 5.98+-0.11 to 145.95+-0.46muM, when compared to the standard drug acarbose.	Acarbose	185-193	sucrase-isomaltase	Homo sapiens	60-77
28482263-4	2017	Molecular docking studies showed that compound 4j have high binding affinities with the active site of alpha-glucosidase enzyme through hydrogen bonds, arene-cation, pi-pi stacking and hydrophobic interactions.	Hydrogen	136-144	sucrase-isomaltase	Homo sapiens	103-120
28482263-4	2017	Molecular docking studies showed that compound 4j have high binding affinities with the active site of alpha-glucosidase enzyme through hydrogen bonds, arene-cation, pi-pi stacking and hydrophobic interactions.	arene	152-157	sucrase-isomaltase	Homo sapiens	103-120
28482263-5	2017	This study showed these 3,3-di(indolyl)indolin-2-ones as a new class of alpha-glucosidase inhibitors.	3,3-di(indolyl)indolin-2-ones	24-53	sucrase-isomaltase	Homo sapiens	72-89
28454670-6	2017	Regarding the inhibition of alpha-glucosidase, naringenin exhibited more potent inhibitory activity (IC50: 10.6+-0.49microM) than its glycosylated forms and the reference inhibitor, acarbose (IC50: 178.0+-0.27microM).	naringenin	47-57	sucrase-isomaltase	Homo sapiens	28-45
28704188-13	2017	Methanol and aqueous extracts there were found to be effective inhibitors of alpha-glucosidase with an IC50 value of 20 mug GAE/ml and 55 mug GAE/ml, respectively.	gae	124-127	sucrase-isomaltase	Homo sapiens	77-94
28704188-13	2017	Methanol and aqueous extracts there were found to be effective inhibitors of alpha-glucosidase with an IC50 value of 20 mug GAE/ml and 55 mug GAE/ml, respectively.	gae	142-145	sucrase-isomaltase	Homo sapiens	77-94
28470323-2	2017	Inhibition of alpha-amylase and alpha-glucosidase enzymes using natural products (especially polyphenols) is a novel oral policy to regulate carbohydrate metabolism and hyperglycemia.	Polyphenols	93-104	sucrase-isomaltase	Homo sapiens	32-49
28584574-0	2017	Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells.	Water	85-90	sucrase-isomaltase	Homo sapiens	33-50
30263598-0	2017	Improved synthesis of isomaltooligosaccharides using immobilized alpha-glucosidase in organic-aqueous media.	isomaltooligosaccharides	22-46	sucrase-isomaltase	Homo sapiens	65-82
30263598-1	2017	alpha-Glucosidase was immobilized onto an epoxy-activated resin (Eupergit C) to catalyze maltose into isomaltooligosaccharides (IMO), and then the effects of organic-aqueous media on the enzymatic properties of immobilized alpha-glucosidase were examined.	Maltose	89-96	sucrase-isomaltase	Homo sapiens	0-17
30263598-1	2017	alpha-Glucosidase was immobilized onto an epoxy-activated resin (Eupergit C) to catalyze maltose into isomaltooligosaccharides (IMO), and then the effects of organic-aqueous media on the enzymatic properties of immobilized alpha-glucosidase were examined.	isomaltooligosaccharides	102-126	sucrase-isomaltase	Homo sapiens	0-17
30263598-1	2017	alpha-Glucosidase was immobilized onto an epoxy-activated resin (Eupergit C) to catalyze maltose into isomaltooligosaccharides (IMO), and then the effects of organic-aqueous media on the enzymatic properties of immobilized alpha-glucosidase were examined.	6-o-phosphoryl inosine monophosphate	128-131	sucrase-isomaltase	Homo sapiens	0-17
30108859-0	2017	Synthesis, alpha-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.	thiazolidine-2,4-dione	79-101	sucrase-isomaltase	Homo sapiens	11-28
30108859-0	2017	Synthesis, alpha-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.	Rhodanine	105-114	sucrase-isomaltase	Homo sapiens	11-28
28470323-2	2017	Inhibition of alpha-amylase and alpha-glucosidase enzymes using natural products (especially polyphenols) is a novel oral policy to regulate carbohydrate metabolism and hyperglycemia.	Carbohydrates	141-153	sucrase-isomaltase	Homo sapiens	32-49
28470323-3	2017	The present study aims to evaluate the alpha-amylase and alpha-glucosidase inhibitory activity of 26 polyphenols using molecular docking and virtual screening studies.	Polyphenols	101-112	sucrase-isomaltase	Homo sapiens	57-74
28470323-6	2017	Therefore the primary structure of polyphenols can change the inhibitory effect versus the alpha-amylase and alpha-glucosidase enzymes.	Polyphenols	35-46	sucrase-isomaltase	Homo sapiens	109-126
28584404-0	2017	The alpha-glucosidase inhibitor voglibose stimulates delayed gastric emptying in healthy subjects: a crossover study with a 13C breath test.	voglibose	32-41	sucrase-isomaltase	Homo sapiens	4-21
28393419-2	2017	In the frames of this research study, several triazolo- and pyrazolotriazines were synthesized and evaluated as inhibitors of AGE products formation, DPP4, glycogen phosphorylase and alpha-glucosidase activities, as well as AGE cross-link breakers.	triazolo- and pyrazolotriazines	46-77	sucrase-isomaltase	Homo sapiens	183-200
28242551-0	2017	Analogues of xanthones--Chalcones and bis-chalcones as alpha-glucosidase inhibitors and anti-diabetes candidates.	Xanthones	13-22	sucrase-isomaltase	Homo sapiens	55-72
28240909-0	2017	alpha-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.	Diterpenes	50-62	sucrase-isomaltase	Homo sapiens	0-17
28240909-5	2017	In the present work, taxanes were found to exhibit alpha-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 muM.	Taxoids	21-28	sucrase-isomaltase	Homo sapiens	51-68
28242551-0	2017	Analogues of xanthones--Chalcones and bis-chalcones as alpha-glucosidase inhibitors and anti-diabetes candidates.	Chalcones	24-33	sucrase-isomaltase	Homo sapiens	55-72
28242551-0	2017	Analogues of xanthones--Chalcones and bis-chalcones as alpha-glucosidase inhibitors and anti-diabetes candidates.	bis-chalcones	38-51	sucrase-isomaltase	Homo sapiens	55-72
28242551-1	2017	Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as alpha-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro.	bis-chalcones	39-52	sucrase-isomaltase	Homo sapiens	99-116
28242551-2	2017	Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards alpha-glucosidase with noncompetitive mechanism.	1-DEOXYNOJIRIMYCIN	96-114	sucrase-isomaltase	Homo sapiens	123-140
28242551-3	2017	Moreover, most of the hydroxy bis-chalcones exhibit good alpha-glucosidase inhibitory activities in enzyme test.	hydroxy bis-chalcones	22-43	sucrase-isomaltase	Homo sapiens	57-74
28130771-1	2017	INTRODUCTION: The alpha-glucosidase inhibitor acarbose is an efficacious medicine for the treatment and prevention of type 2 diabetes mellitus (T2DM).	Acarbose	46-54	sucrase-isomaltase	Homo sapiens	18-35
28425975-0	2017	Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as alpha-Glucosidase Inhibitors.	isatin-thiazole	73-88	sucrase-isomaltase	Homo sapiens	104-121
28425975-1	2017	A series of novel isatin-thiazole derivatives were synthesized and screened for their in vitro alpha-glucosidase inhibitory activity.	isatin-thiazole	18-33	sucrase-isomaltase	Homo sapiens	95-112
28425975-2	2017	These compounds displayed a varying degree of alpha-glucosidase inhibitory activity with IC50 ranging from 5.36 +- 0.13 to 35.76 +- 0.31 mum as compared to the standard drug acarbose (IC50 = 817.38 +- 6.27 mum).	Acarbose	174-182	sucrase-isomaltase	Homo sapiens	46-63
28425975-4	2017	Molecular docking studies revealed the existence of hydrophobic interaction, CH-pi interaction, arene-anion interaction, arene-cation interaction, and hydrogen bond between these compounds and alpha-glucosidase enzyme.	Hydrogen	151-159	sucrase-isomaltase	Homo sapiens	193-210
28160945-0	2017	In search of new alpha-glucosidase inhibitors: Imidazolylpyrazole derivatives.	imidazolylpyrazole	47-65	sucrase-isomaltase	Homo sapiens	17-34
28160945-2	2017	alpha-Glucosidase inhibition assay revealed a new class of highly potent agents wherein each compound displayed significant inhibitory potentials (in terms of percentage inhibition and relative IC50 values) as compared to that of the reference drug (Acarbose).	Acarbose	250-258	sucrase-isomaltase	Homo sapiens	0-17
28272319-0	2017	Facilitated Visual Interpretation of Scores in Principal Component Analysis by Bioactivity-Labeling of 1H-NMR Spectra-Metabolomics Investigation and Identification of a New alpha-Glucosidase Inhibitor in Radix Astragali.	Hydrogen	103-105	sucrase-isomaltase	Homo sapiens	173-190
28358057-0	2017	Synthesis and biological evaluation of novel ursolic acid analogues as potential alpha-glucosidase inhibitors.	ursolic acid	45-57	sucrase-isomaltase	Homo sapiens	81-98
28333091-3	2017	We summarized here recent advances in our understanding of the regulation of glucose metabolism using bioactive peptides from natural proteins, including regulation of insulin-regulated glucose metabolism, such as protection and reparation of pancreatic beta-cells, enhancing glucose-stimulated insulin secretion and influencing the sensitivity of insulin and the signaling pathways, and inhibition of bioactive peptides to dipeptidyl peptidase IV, alpha-amylase and alpha-glucosidase activities.	Glucose	77-84	sucrase-isomaltase	Homo sapiens	467-484
28333091-3	2017	We summarized here recent advances in our understanding of the regulation of glucose metabolism using bioactive peptides from natural proteins, including regulation of insulin-regulated glucose metabolism, such as protection and reparation of pancreatic beta-cells, enhancing glucose-stimulated insulin secretion and influencing the sensitivity of insulin and the signaling pathways, and inhibition of bioactive peptides to dipeptidyl peptidase IV, alpha-amylase and alpha-glucosidase activities.	Glucose	186-193	sucrase-isomaltase	Homo sapiens	467-484
28333091-3	2017	We summarized here recent advances in our understanding of the regulation of glucose metabolism using bioactive peptides from natural proteins, including regulation of insulin-regulated glucose metabolism, such as protection and reparation of pancreatic beta-cells, enhancing glucose-stimulated insulin secretion and influencing the sensitivity of insulin and the signaling pathways, and inhibition of bioactive peptides to dipeptidyl peptidase IV, alpha-amylase and alpha-glucosidase activities.	Glucose	186-193	sucrase-isomaltase	Homo sapiens	467-484
28272319-2	2017	Radix Astragali is known to contain isoflavones, which inhibit alpha-glucosidase in the small intestines, and thus lowers the blood glucose levels.	Isoflavones	36-47	sucrase-isomaltase	Homo sapiens	63-80
28272319-4	2017	A principal component analysis of the 1H-NMR spectra labeled with their IC50-values, that is, bioactivity-labeled 1H-NMR spectra, showed a clear correlation between spectral profiles and the alpha-glucosidase inhibitory activity.	Hydrogen	38-40	sucrase-isomaltase	Homo sapiens	191-208
28272319-4	2017	A principal component analysis of the 1H-NMR spectra labeled with their IC50-values, that is, bioactivity-labeled 1H-NMR spectra, showed a clear correlation between spectral profiles and the alpha-glucosidase inhibitory activity.	Hydrogen	114-116	sucrase-isomaltase	Homo sapiens	191-208
28272319-6	2017	Subsequent preparative scale isolation revealed a compound not previously reported, linoleyl ferulate (1), showing alpha-glucosidase inhibitory activity (IC50 0.5 mM) at a level comparable to the previously studied isoflavones.	Linoleyl Ferulate	84-101	sucrase-isomaltase	Homo sapiens	115-132
28272319-7	2017	A closely related analogue, hexadecyl ferulate (2), did not show significant inhibitory activity, and the double bonds in the alcohol part of 1 seem to be important structural features for the alpha-glucosidase inhibitory activity.	Hexadecyl ferulate	28-46	sucrase-isomaltase	Homo sapiens	193-210
28272319-7	2017	A closely related analogue, hexadecyl ferulate (2), did not show significant inhibitory activity, and the double bonds in the alcohol part of 1 seem to be important structural features for the alpha-glucosidase inhibitory activity.	Alcohols	126-133	sucrase-isomaltase	Homo sapiens	193-210
28062276-1	2017	BACKGROUND &amp; AIMS: Congenital sucrase-isomaltase deficiency (CSID) is a genetic disorder associated with mutations in the sucrase-isomaltase (SI) gene.	Adenosine Monophosphate	12-15	sucrase-isomaltase	Homo sapiens	34-52
27596404-4	2017	Furthermore, resveratrol acted as a competitive inhibitor for alpha-amylase with IC50 3.62mug/ml, while it behaved in an uncompetitive manner for alpha-glucosidase with an IC50 of 17.54mug/l.	Resveratrol	13-24	sucrase-isomaltase	Homo sapiens	146-163
28189421-0	2017	Synthesis, molecular docking and alpha-glucosidase inhibition of 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-N-arylacetamides.	2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-n-arylacetamides	65-123	sucrase-isomaltase	Homo sapiens	33-50
28189421-1	2017	A novel series of 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-N-arylacetamides 5a-5q have been synthesized and evaluated for their alpha-glucosidase inhibitory activity.	2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-n-arylacetamides 5a-5q	18-82	sucrase-isomaltase	Homo sapiens	129-146
28189421-2	2017	All newly synthesized compounds exhibited potent alpha-glucosidase inhibitory activity in the range of IC50=12.46+-0.13-72.68+-0.20muM, when compared to the standard drug acarbose (IC50=817.38+-6.27muM).	Acarbose	171-179	sucrase-isomaltase	Homo sapiens	49-66
28189421-3	2017	Among the series, compound 5j (12.46+-0.13muM) with strong electron-withdrawing nitro group on the arylacetamide moiety was identified as the most potent inhibitor of alpha-glucosidase.	nitro	80-85	sucrase-isomaltase	Homo sapiens	167-184
28189421-3	2017	Among the series, compound 5j (12.46+-0.13muM) with strong electron-withdrawing nitro group on the arylacetamide moiety was identified as the most potent inhibitor of alpha-glucosidase.	arylacetamide	99-112	sucrase-isomaltase	Homo sapiens	167-184
28137512-5	2017	Monochloropivaloylquercetin (CPQ), monoacetylferuloylquercetin (MAFQ) and chloronaphthoquinonequercetin (CHNQ) showed a prominent inhibitory effect on the key enzymes involved in diabetic complications, aldose reductase and alpha-glucosidase, suggesting their promising therapeutic application.	monochloropivaloylquercetin	0-27	sucrase-isomaltase	Homo sapiens	224-241
28137512-5	2017	Monochloropivaloylquercetin (CPQ), monoacetylferuloylquercetin (MAFQ) and chloronaphthoquinonequercetin (CHNQ) showed a prominent inhibitory effect on the key enzymes involved in diabetic complications, aldose reductase and alpha-glucosidase, suggesting their promising therapeutic application.	cpq	29-32	sucrase-isomaltase	Homo sapiens	224-241
28137512-5	2017	Monochloropivaloylquercetin (CPQ), monoacetylferuloylquercetin (MAFQ) and chloronaphthoquinonequercetin (CHNQ) showed a prominent inhibitory effect on the key enzymes involved in diabetic complications, aldose reductase and alpha-glucosidase, suggesting their promising therapeutic application.	monoacetylferuloylquercetin	35-62	sucrase-isomaltase	Homo sapiens	224-241
28137512-5	2017	Monochloropivaloylquercetin (CPQ), monoacetylferuloylquercetin (MAFQ) and chloronaphthoquinonequercetin (CHNQ) showed a prominent inhibitory effect on the key enzymes involved in diabetic complications, aldose reductase and alpha-glucosidase, suggesting their promising therapeutic application.	mafq	64-68	sucrase-isomaltase	Homo sapiens	224-241
28137512-5	2017	Monochloropivaloylquercetin (CPQ), monoacetylferuloylquercetin (MAFQ) and chloronaphthoquinonequercetin (CHNQ) showed a prominent inhibitory effect on the key enzymes involved in diabetic complications, aldose reductase and alpha-glucosidase, suggesting their promising therapeutic application.	chloronaphthoquinonequercetin	74-103	sucrase-isomaltase	Homo sapiens	224-241
28137512-5	2017	Monochloropivaloylquercetin (CPQ), monoacetylferuloylquercetin (MAFQ) and chloronaphthoquinonequercetin (CHNQ) showed a prominent inhibitory effect on the key enzymes involved in diabetic complications, aldose reductase and alpha-glucosidase, suggesting their promising therapeutic application.	chnq	105-109	sucrase-isomaltase	Homo sapiens	224-241
27910158-10	2017	The crude water extract, the methanol extract, and the methanol extract derived AQ fraction showed alpha-glucosidase inhibiting effects.	Water	10-15	sucrase-isomaltase	Homo sapiens	99-116
27910158-10	2017	The crude water extract, the methanol extract, and the methanol extract derived AQ fraction showed alpha-glucosidase inhibiting effects.	Methanol	29-37	sucrase-isomaltase	Homo sapiens	99-116
27910158-10	2017	The crude water extract, the methanol extract, and the methanol extract derived AQ fraction showed alpha-glucosidase inhibiting effects.	Methanol	55-63	sucrase-isomaltase	Homo sapiens	99-116
27910158-10	2017	The crude water extract, the methanol extract, and the methanol extract derived AQ fraction showed alpha-glucosidase inhibiting effects.	aq	80-82	sucrase-isomaltase	Homo sapiens	99-116
27910158-12	2017	They were identified as the novel 2-caffeoyloxy-4-hydroxy-glutaric acid and the diastereomers secundarellone B and C. CONCLUSION: The current study presents the alpha-glucosidase inhibiting potential of J. secunda supporting its traditional medicinal use in diabetes mellitus treatment.	2-caffeoyloxy-4-hydroxy-glutaric acid	34-71	sucrase-isomaltase	Homo sapiens	161-178
28110817-0	2017	Quinazolinone derivatives: Synthesis and comparison of inhibitory mechanisms on alpha-glucosidase.	Quinazolinones	0-13	sucrase-isomaltase	Homo sapiens	80-97
28110817-3	2017	Two compounds: 2-(4-chlorophenyl)-quinazolin-4(3H)-one (CQ) and 2-(4-bromophenyl)-quinazolin-4(3H)-one (BQ) were found to be potent inhibitors of alpha-glucosidase with IC50 values of 12.5+-0.1muM and 15.6+-0.2muM, respectively.	2-(4-chlorophenyl)-quinazolin-4(3h)-one	15-54	sucrase-isomaltase	Homo sapiens	146-163
28110817-3	2017	Two compounds: 2-(4-chlorophenyl)-quinazolin-4(3H)-one (CQ) and 2-(4-bromophenyl)-quinazolin-4(3H)-one (BQ) were found to be potent inhibitors of alpha-glucosidase with IC50 values of 12.5+-0.1muM and 15.6+-0.2muM, respectively.	2-(4-bromophenyl)-quinazolin-4(3h)-one	64-102	sucrase-isomaltase	Homo sapiens	146-163
28110817-6	2017	CQ and BQ could statically quench the fluorescence spectra by formation of an inhibitor-alpha-glucosidase complex.	Chloroquine	0-2	sucrase-isomaltase	Homo sapiens	88-105
28110817-6	2017	CQ and BQ could statically quench the fluorescence spectra by formation of an inhibitor-alpha-glucosidase complex.	bulaquine	7-9	sucrase-isomaltase	Homo sapiens	88-105
28110817-7	2017	The interaction between CQ and alpha-glucosidase depended on hydrogen bonds, electrostatic and hydrophobic force, while the driving force of the binding between BQ and the enzyme was hydrophobic.	Chloroquine	24-26	sucrase-isomaltase	Homo sapiens	31-48
28110817-7	2017	The interaction between CQ and alpha-glucosidase depended on hydrogen bonds, electrostatic and hydrophobic force, while the driving force of the binding between BQ and the enzyme was hydrophobic.	Hydrogen	61-69	sucrase-isomaltase	Homo sapiens	31-48
28110817-8	2017	The docking results showed that BQ was less active than CQ against alpha-glucosidase because of its weaker interaction with the enzyme.	bulaquine	32-34	sucrase-isomaltase	Homo sapiens	67-84
28110817-8	2017	The docking results showed that BQ was less active than CQ against alpha-glucosidase because of its weaker interaction with the enzyme.	Chloroquine	56-58	sucrase-isomaltase	Homo sapiens	67-84
27616456-0	2017	Synthesis, in vitro evaluation and molecular docking studies of novel coumarin-isatin derivatives as alpha-glucosidase inhibitors.	coumarin-isatin	70-85	sucrase-isomaltase	Homo sapiens	101-118
27616456-1	2017	This study synthesized a series of novel coumarin-isatin derivatives and evaluated them for alpha-glucosidase inhibitory activity.	coumarin-isatin	41-56	sucrase-isomaltase	Homo sapiens	92-109
27616456-5	2017	Molecular docking analysis revealed the existence of hydrophobic and hydrogen interactions between compound 5p and the active site of alpha-glucosidase.	Hydrogen	69-77	sucrase-isomaltase	Homo sapiens	134-151
27616456-6	2017	Our results indicate that coumarin-isatin derivatives as a new class of alpha-glucosidase inhibitors.	coumarin-isatin	26-41	sucrase-isomaltase	Homo sapiens	72-89
27400121-0	2017	Three new resin glycosides compounds from Argyreia acuta and their alpha-glucosidase inhibitory activity.	Glycosides	16-26	sucrase-isomaltase	Homo sapiens	67-84
28118069-6	2017	Older classes of oral glucose-lowering treatments administered at mealtime to lower PPG include meglitinides and alpha-glucosidase inhibitors.	Glucose	22-29	sucrase-isomaltase	Homo sapiens	113-130
28107971-5	2017	With the modification of chitosan (CS) and glutaraldehyde (GA), alpha-glucosidase was successfully immobilized on the magnetic nanoparticles.	Chitosan	25-33	sucrase-isomaltase	Homo sapiens	64-81
28107971-5	2017	With the modification of chitosan (CS) and glutaraldehyde (GA), alpha-glucosidase was successfully immobilized on the magnetic nanoparticles.	Chitosan	35-37	sucrase-isomaltase	Homo sapiens	64-81
28107971-5	2017	With the modification of chitosan (CS) and glutaraldehyde (GA), alpha-glucosidase was successfully immobilized on the magnetic nanoparticles.	Glutaral	43-57	sucrase-isomaltase	Homo sapiens	64-81
28107971-5	2017	With the modification of chitosan (CS) and glutaraldehyde (GA), alpha-glucosidase was successfully immobilized on the magnetic nanoparticles.	Glutaral	59-61	sucrase-isomaltase	Homo sapiens	64-81
28107971-7	2017	With the magnetic immobilized alpha-glucosidase, the Michaelis-Menten constant (Km) was calculated to be 0.85mM, and the inhibition constant (Ki) and half-maximal inhibitory concentration (IC50) for acarbose were determined to be 7.37 and 13.69muM, respectively.	Acarbose	199-207	sucrase-isomaltase	Homo sapiens	30-47
28212341-5	2017	alpha,beta-Amyrenone significantly inhibited alpha-glucosidase (96.5% +- 0.52%) at a concentration of 1.6 g/mL.	beta-amyrenone	6-20	sucrase-isomaltase	Homo sapiens	45-62
27894824-0	2017	Inhibitory effect of phloretin on alpha-glucosidase: Kinetics, interaction mechanism and molecular docking.	Phloretin	21-30	sucrase-isomaltase	Homo sapiens	34-51
27894824-2	2017	In this study, multispectroscopic techniques and molecular docking analysis were used to investigate the inhibitory activity and mechanisms of phloretin on alpha-glucosidase.	Phloretin	143-152	sucrase-isomaltase	Homo sapiens	156-173
27894824-3	2017	The results showed that phloretin reversibly inhibited alpha-glucosidase in a mixed-type manner and the value of IC50 was 31.26mugL-1.	Phloretin	24-33	sucrase-isomaltase	Homo sapiens	55-72
27894824-4	2017	The intrinsic fluorescence of alpha-glucosidase was quenched by the interactions with phloretin through a static quenching mechanism and spontaneously formed phloretin-alpha-glucosidase complex by the driving forces of van der Waals force and hydrogen bond.	Phloretin	86-95	sucrase-isomaltase	Homo sapiens	30-47
27894824-4	2017	The intrinsic fluorescence of alpha-glucosidase was quenched by the interactions with phloretin through a static quenching mechanism and spontaneously formed phloretin-alpha-glucosidase complex by the driving forces of van der Waals force and hydrogen bond.	Hydrogen	243-251	sucrase-isomaltase	Homo sapiens	30-47
27894824-4	2017	The intrinsic fluorescence of alpha-glucosidase was quenched by the interactions with phloretin through a static quenching mechanism and spontaneously formed phloretin-alpha-glucosidase complex by the driving forces of van der Waals force and hydrogen bond.	Hydrogen	243-251	sucrase-isomaltase	Homo sapiens	168-185
27894824-5	2017	Atomic force microscope (AFM) studies and FT-IR measurements suggested that the interactions could change the micro-environments and conformation of the enzymes and the molecular docking analysis displayed the exact binding site of phloretin on alpha-glucosidase.	Phloretin	232-241	sucrase-isomaltase	Homo sapiens	245-262
27894824-6	2017	These results indicated that phloretin is a strong alpha-glucosidase inhibitor, thus could be contribute to the improvement of diabetes mellitus.	Phloretin	29-38	sucrase-isomaltase	Homo sapiens	51-68
28668259-0	2017	Ayurvedic anti-diabetic formulation Lodhrasavam inhibits alpha-amylase, alpha-glucosidase and suppresses adipogenic activity in vitro.	lodhrasavam	36-47	sucrase-isomaltase	Homo sapiens	72-89
27388525-0	2017	Antidiabetic effect of chitosan oligosaccharide (GO2KA1) is mediated via inhibition of intestinal alpha-glucosidase and glucose transporters and PPARgamma expression.	D-Glucosaminide	23-47	sucrase-isomaltase	Homo sapiens	98-115
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Starch	116-122	sucrase-isomaltase	Homo sapiens	30-47
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Starch	116-122	sucrase-isomaltase	Homo sapiens	49-58
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Sugars	128-134	sucrase-isomaltase	Homo sapiens	30-47
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Sugars	128-134	sucrase-isomaltase	Homo sapiens	49-58
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Disaccharides	139-152	sucrase-isomaltase	Homo sapiens	30-47
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Disaccharides	139-152	sucrase-isomaltase	Homo sapiens	49-58
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Glucose	186-193	sucrase-isomaltase	Homo sapiens	30-47
27558678-3	2017	alpha-Amylase (alpha-Amy) and alpha-glucosidase (alpha-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level.	Glucose	186-193	sucrase-isomaltase	Homo sapiens	49-58
28045172-0	2017	The kinetics and mechanism of alpha-glucosidase inhibition by F5-SP, a novel compound derived from sericin peptides.	f5-sp	62-67	sucrase-isomaltase	Homo sapiens	30-47
28045172-1	2017	The inhibition of alpha-glucosidase decreases postprandial blood glucose and therefore plays an important role in the treatment of type 2 diabetes mellitus.	Glucose	65-72	sucrase-isomaltase	Homo sapiens	18-35
28045172-5	2017	F5-SPs can bind to alpha-glucosidase at multiple sites to alter the conformation of alpha-glucosidase.	f5-sps	0-6	sucrase-isomaltase	Homo sapiens	19-36
28045172-5	2017	F5-SPs can bind to alpha-glucosidase at multiple sites to alter the conformation of alpha-glucosidase.	f5-sps	0-6	sucrase-isomaltase	Homo sapiens	84-101
28045172-7	2017	Fluorescence spectra analysis showed that F5-SPs quenched the intrinsic fluorescence of alpha-glucosidase by a static quenching mechanism, and circular dichroism analysis suggested that the binding of F5-SPs to alpha-glucosidase resulted in the alteration of the secondary structure of an enzyme.	f5-sps	42-48	sucrase-isomaltase	Homo sapiens	88-105
28045172-7	2017	Fluorescence spectra analysis showed that F5-SPs quenched the intrinsic fluorescence of alpha-glucosidase by a static quenching mechanism, and circular dichroism analysis suggested that the binding of F5-SPs to alpha-glucosidase resulted in the alteration of the secondary structure of an enzyme.	f5-sps	42-48	sucrase-isomaltase	Homo sapiens	211-228
28045172-7	2017	Fluorescence spectra analysis showed that F5-SPs quenched the intrinsic fluorescence of alpha-glucosidase by a static quenching mechanism, and circular dichroism analysis suggested that the binding of F5-SPs to alpha-glucosidase resulted in the alteration of the secondary structure of an enzyme.	f5-sps	201-207	sucrase-isomaltase	Homo sapiens	88-105
28045172-7	2017	Fluorescence spectra analysis showed that F5-SPs quenched the intrinsic fluorescence of alpha-glucosidase by a static quenching mechanism, and circular dichroism analysis suggested that the binding of F5-SPs to alpha-glucosidase resulted in the alteration of the secondary structure of an enzyme.	f5-sps	201-207	sucrase-isomaltase	Homo sapiens	211-228
27956035-0	2017	Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for alpha-glucosidase recognition.	1-Deoxynojirimycin	65-68	sucrase-isomaltase	Homo sapiens	85-102
27956035-3	2017	The two synthetic conjugates, DNJ-CF31 and DNJ-Me 2, exhibited improved alpha-glucosidase inhibitory effects compared to DNJ and miglitol.	dnj-cf31	30-38	sucrase-isomaltase	Homo sapiens	72-89
27956035-3	2017	The two synthetic conjugates, DNJ-CF31 and DNJ-Me 2, exhibited improved alpha-glucosidase inhibitory effects compared to DNJ and miglitol.	dnj-me 2	43-51	sucrase-isomaltase	Homo sapiens	72-89
27956035-3	2017	The two synthetic conjugates, DNJ-CF31 and DNJ-Me 2, exhibited improved alpha-glucosidase inhibitory effects compared to DNJ and miglitol.	1-Deoxynojirimycin	30-33	sucrase-isomaltase	Homo sapiens	72-89
27689725-0	2017	Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential alpha-glucosidase inhibitors.	Triazines	70-78	sucrase-isomaltase	Homo sapiens	113-130
27689725-0	2017	Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential alpha-glucosidase inhibitors.	Triazoles	79-87	sucrase-isomaltase	Homo sapiens	113-130
27689725-1	2017	A novel series of triazine-triazole derivatives 7a-7m were synthesized, characterized by 1H NMR and evaluated for their alpha-glucosidase inhibitory activity.	triazine-triazole	18-35	sucrase-isomaltase	Homo sapiens	120-137
27689725-2	2017	All the synthesized compounds displayed potent alpha-glucosidase inhibitory activity with IC50 range of 11.63 +- 0.15 to 37.44 +- 0.35 muM, when compared to the standard drug acarbose (IC50 = 817.38 +- 6.27 muM).	Acarbose	175-183	sucrase-isomaltase	Homo sapiens	47-64
27689725-3	2017	Among the series, compound 7i (IC50 = 11.63 +- 0.15 muM) bearing 2,5-dichloro substitution at phenyl ring, represented the most potent alpha-glucosidase inhibitory activity.	2,5-dichloro	65-77	sucrase-isomaltase	Homo sapiens	135-152
27689725-5	2017	Our studies shown that these triazine-triazole derivatives are a new class of alpha-glucosidase inhibitors.	triazine-triazole	29-46	sucrase-isomaltase	Homo sapiens	78-95
28093996-7	2017	Also, alpha-glucosidase inhibitors decrease the polysaccharides" digestion in small intestine and are less effective in comparison to metformin and sulfonylureas in lowering hemoglobin A1c (HbA1c).	Polysaccharides	48-63	sucrase-isomaltase	Homo sapiens	6-23
28035984-0	2016	Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on alpha-Glucosidase and Human Protein Tyrosine Phosphatases 1B.	Anthraquinones	32-46	sucrase-isomaltase	Homo sapiens	118-135
28411646-7	2017	Similarly, alpha-glucosidase that was encased in the acid cleavable polymeric nanogel exhibited substantial activity after release under acidic conditions (pH 5, 48h).	48H	162-165	sucrase-isomaltase	Homo sapiens	11-28
28456989-7	2017	This chapter focuses on the activity measurement of three lysosomal enzymes (alpha-glucosidase, beta-glucosidase, and alpha galactosidase) in DBS samples by using fluorescent substrates and by the LC-MS/MS (liquid chromatography-mass spectrometry) method.	dbs	142-145	sucrase-isomaltase	Homo sapiens	77-94
28745232-0	2017	In vitro alpha-Glucosidase Inhibition by Non-sugar based Triazoles of Dibenzoazepine, their Structure-Activity Relationship, and Molecular Docking.	Sugars	45-50	sucrase-isomaltase	Homo sapiens	9-26
28745232-0	2017	In vitro alpha-Glucosidase Inhibition by Non-sugar based Triazoles of Dibenzoazepine, their Structure-Activity Relationship, and Molecular Docking.	Triazoles	57-66	sucrase-isomaltase	Homo sapiens	9-26
28745232-0	2017	In vitro alpha-Glucosidase Inhibition by Non-sugar based Triazoles of Dibenzoazepine, their Structure-Activity Relationship, and Molecular Docking.	Loxapine	70-84	sucrase-isomaltase	Homo sapiens	9-26
28035984-0	2016	Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on alpha-Glucosidase and Human Protein Tyrosine Phosphatases 1B.	naphthopyrone	48-61	sucrase-isomaltase	Homo sapiens	118-135
28035984-0	2016	Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on alpha-Glucosidase and Human Protein Tyrosine Phosphatases 1B.	naphthalene glycosides	67-89	sucrase-isomaltase	Homo sapiens	118-135
28035984-1	2016	The present work aims to evaluate the anti-diabetic potentials of 16 anthraquinones, two naphthopyrone glycosides, and one naphthalene glycoside from Cassia obtusifolia via inhibition against the protein tyrosine phosphatases 1B (PTP1B) and alpha-glucosidase.	naphthalene glycoside	123-144	sucrase-isomaltase	Homo sapiens	241-258
28035984-2	2016	Among them, anthraquinones emodin and alaternin exhibited the highest inhibitory activities on PTP1B and alpha-glucosidase, respectively.	Anthraquinones	12-26	sucrase-isomaltase	Homo sapiens	105-122
28035984-2	2016	Among them, anthraquinones emodin and alaternin exhibited the highest inhibitory activities on PTP1B and alpha-glucosidase, respectively.	2-hydroxyemodin	38-47	sucrase-isomaltase	Homo sapiens	105-122
28035984-5	2016	In addition, our kinetic study revealed that alaternin competitively inhibited PTP1B, and showed mixed-type inhibition against alpha-glucosidase.	2-hydroxyemodin	45-54	sucrase-isomaltase	Homo sapiens	127-144
27810241-0	2016	Synthesis and biological evaluation of novel 2,4,5-triarylimidazole-1,2,3-triazole derivatives via click chemistry as alpha-glucosidase inhibitors.	2,4,5-triarylimidazole-1,2,3-triazole	45-82	sucrase-isomaltase	Homo sapiens	118-135
28066324-0	2016	In Silico Study of Alkaloids as alpha-Glucosidase Inhibitors: Hope for the Discovery of Effective Lead Compounds.	Alkaloids	19-28	sucrase-isomaltase	Homo sapiens	32-49
28066324-1	2016	alpha-Glucosidase (extinction coefficient 3.2.1.20) is a primary carbohydrate metabolizing enzyme that acts on the 1-4 associated alpha-glucose residues.	Carbohydrates	65-77	sucrase-isomaltase	Homo sapiens	0-17
28066324-1	2016	alpha-Glucosidase (extinction coefficient 3.2.1.20) is a primary carbohydrate metabolizing enzyme that acts on the 1-4 associated alpha-glucose residues.	Glucose	136-143	sucrase-isomaltase	Homo sapiens	0-17
28066324-2	2016	The inhibition of alpha-glucosidase slows down the process of carbohydrate digestion and avoids postprandial hyperglycemia, which is a major cause of chronic diabetes-associated complication.	Carbohydrates	62-74	sucrase-isomaltase	Homo sapiens	18-35
28066324-6	2016	The molecular docking of 37 alkaloids along with standard acarbose and miglitol reported as a alpha-glucosidase inhibitor was performed via MOE-Dock implemented in MOE software to find the binding modes of these inhibitors.	Alkaloids	28-37	sucrase-isomaltase	Homo sapiens	94-111
28066324-6	2016	The molecular docking of 37 alkaloids along with standard acarbose and miglitol reported as a alpha-glucosidase inhibitor was performed via MOE-Dock implemented in MOE software to find the binding modes of these inhibitors.	Acarbose	58-66	sucrase-isomaltase	Homo sapiens	94-111
27810241-1	2016	A novel series of 2,4,5-triarylimidazole-1,2,3-triazole derivatives were synthesized via copper(I)-catalyzed azide-alkyne click chemistry, and evaluated for their alpha-glucosidase inhibitory activity.	2,4,5-triarylimidazole-1,2,3-triazole	18-55	sucrase-isomaltase	Homo sapiens	163-180
27810241-2	2016	All tested compounds showed potent alpha-glucosidase inhibitory activity with IC50 ranging from 15.16+-0.18 to 48.15+-0.37muM, in comparison to the standard drug, acarbose (IC50=817.38+-6.27muM).	Acarbose	163-171	sucrase-isomaltase	Homo sapiens	35-52
27454620-0	2016	Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant, anti-cancer, alpha-glucosidase, beta-glucuronidase inhibition and their molecular docking studies.	pyrimidine-2,4,6-trione	13-36	sucrase-isomaltase	Homo sapiens	77-94
26887579-1	2016	A biosensor for measuring the antidiabetic potential of medicinal plants was developed by covalent immobilization of alpha-glucosidase (AG) enzyme onto amine-functionalized multi-walled carbon nanotubes (MWCNTs-NH2).	Amines	152-157	sucrase-isomaltase	Homo sapiens	117-134
26887579-1	2016	A biosensor for measuring the antidiabetic potential of medicinal plants was developed by covalent immobilization of alpha-glucosidase (AG) enzyme onto amine-functionalized multi-walled carbon nanotubes (MWCNTs-NH2).	Amines	152-157	sucrase-isomaltase	Homo sapiens	136-138
26887579-1	2016	A biosensor for measuring the antidiabetic potential of medicinal plants was developed by covalent immobilization of alpha-glucosidase (AG) enzyme onto amine-functionalized multi-walled carbon nanotubes (MWCNTs-NH2).	Carbon	186-192	sucrase-isomaltase	Homo sapiens	117-134
26887579-1	2016	A biosensor for measuring the antidiabetic potential of medicinal plants was developed by covalent immobilization of alpha-glucosidase (AG) enzyme onto amine-functionalized multi-walled carbon nanotubes (MWCNTs-NH2).	Carbon	186-192	sucrase-isomaltase	Homo sapiens	136-138
27576293-0	2016	Molecular docking studies and synthesis of novel bisbenzimidazole derivatives as inhibitors of alpha-glucosidase.	Pibenzimol	49-65	sucrase-isomaltase	Homo sapiens	95-112
27576293-5	2016	The results may suggest a significant role for the nature of bisbenzimidazole compounds in their inhibitory action against alpha-glucosidase.	Pibenzimol	61-77	sucrase-isomaltase	Homo sapiens	123-140
27576293-6	2016	They showed different range of alpha-glucosidase inhibitory potential with IC50 value ranging between 0.44+-0.04 and 6.69+-0.01muM when compared to the standard acarbose (IC50, 13.34+-1.26muM).	Acarbose	161-169	sucrase-isomaltase	Homo sapiens	31-48
27338734-0	2016	Synthesis of furofuran lignans as antidiabetic agents simultaneously achieved by inhibiting alpha-glucosidase and free radical.	furofuran lignans	13-30	sucrase-isomaltase	Homo sapiens	92-109
27338734-5	2016	On examination their inhibitions against alpha-glucosidase and free radicals, lignans having a free hydroxy group showed considerably enhanced inhibition, compared with their corresponding starter 4 and related lignans sesamin (1) and sesamolin (3).	Lignans	78-85	sucrase-isomaltase	Homo sapiens	41-58
27338734-6	2016	In addition, the mechanism underlying the alpha-glucosidase inhibition of a particular active lignan (epi -6) was verified to be mixed manner between competitive and noncompetitive inhibition.	Lignans	94-100	sucrase-isomaltase	Homo sapiens	42-59
27487567-0	2016	Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as alpha-glucosidase inhibitors.	tetracyclic oxindole	58-78	sucrase-isomaltase	Homo sapiens	94-111
27487567-1	2016	alpha-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose.	Carbohydrates	67-80	sucrase-isomaltase	Homo sapiens	0-17
27487567-1	2016	alpha-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose.	Carbohydrates	106-119	sucrase-isomaltase	Homo sapiens	0-17
27487567-1	2016	alpha-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose.	Blood Glucose	123-136	sucrase-isomaltase	Homo sapiens	0-17
27487567-2	2016	Three series of tetracyclic oxindole derivatives were designed, synthesized and evaluated for alpha-glucosidase inhibitory activity in vitro.	tetracyclic oxindole	16-36	sucrase-isomaltase	Homo sapiens	94-111
27614916-0	2016	Synthesis, biological evaluation and molecular docking study of N-arylbenzo[d]oxazol-2-amines as potential alpha-glucosidase inhibitors.	n-arylbenzo[d]oxazol-2-amines	64-93	sucrase-isomaltase	Homo sapiens	107-124
27614916-1	2016	A novel series of N-arylbenzo[d]oxazol-2-amines (4a-4m) were synthesized and evaluated for their alpha-glucosidase inhibitory activity.	n-arylbenzo[d]oxazol-2-amines	18-47	sucrase-isomaltase	Homo sapiens	97-114
27614916-2	2016	Compounds 4f-4i, 4k and 4m displayed potent inhibitory activity against alpha-glucosidase with IC50 values in the range of 32.49+-0.17-120.24+-0.51muM as compared to the standard drug acarbose.	Acarbose	184-192	sucrase-isomaltase	Homo sapiens	72-89
27524059-0	2016	Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and alpha-glucosidase inhibition activities.	flavonoid fisetin	29-46	sucrase-isomaltase	Homo sapiens	89-106
27693584-1	2016	Pompe disease is caused by a deficiency in the lysosomal enzyme alpha-glucosidase, and this leads to glycogen accumulation in the autolysosomes of patient cells.	Glycogen	101-109	sucrase-isomaltase	Homo sapiens	64-81
28035340-6	2016	Of the calorie restriction mimetics being investigated, we focus on the type 2 diabetes drug acarbose, an alpha-glucosidase inhibitor that when taken with a meal, results in reduced enzymatic degradation and absorption of glucose from complex carbohydrates.	Acarbose	93-101	sucrase-isomaltase	Homo sapiens	106-123
28035340-6	2016	Of the calorie restriction mimetics being investigated, we focus on the type 2 diabetes drug acarbose, an alpha-glucosidase inhibitor that when taken with a meal, results in reduced enzymatic degradation and absorption of glucose from complex carbohydrates.	Glucose	222-229	sucrase-isomaltase	Homo sapiens	106-123
28035340-6	2016	Of the calorie restriction mimetics being investigated, we focus on the type 2 diabetes drug acarbose, an alpha-glucosidase inhibitor that when taken with a meal, results in reduced enzymatic degradation and absorption of glucose from complex carbohydrates.	Carbohydrates	243-256	sucrase-isomaltase	Homo sapiens	106-123
27371923-0	2016	Syntheses of new 3-thiazolyl coumarin derivatives, in vitro alpha-glucosidase inhibitory activity, and molecular modeling studies.	3-thiazolyl coumarin	17-37	sucrase-isomaltase	Homo sapiens	60-77
27371923-1	2016	3-Thiazolylcoumarin derivatives 1-14 were synthesized via one-pot two step reactions, and screened for in vitro alpha-glucosidase inhibitory activity.	3-thiazolylcoumarin	0-19	sucrase-isomaltase	Homo sapiens	112-129
27592296-0	2016	Synthesis, in vitro alpha-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives.	Thiazoles	95-103	sucrase-isomaltase	Homo sapiens	20-37
27592296-1	2016	Current study based on the synthesis of new thiazole derivatives via "one pot" multicomponent reaction, evaluation of their in vitro alpha-glucosidase inhibitory activities, and in silico studies.	Thiazoles	44-52	sucrase-isomaltase	Homo sapiens	133-150
27572707-0	2016	A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies.	benzimidazole	83-96	sucrase-isomaltase	Homo sapiens	56-73
27262298-1	2016	Bioactivity-guided fractionation of an aqueous methanolic extract of manufactured gambir product from Uncaria gambir with in vitro alpha-glucosidase inhibitory activity was performed to isolate a novel prenyl resorcinol derivative (1) together with seven known compounds, including two flavone glycosides (2, 3), three catechin analogues (4-6), and two simple phenolics (7, 8).	methanolic	47-57	sucrase-isomaltase	Homo sapiens	131-148
27450115-2	2016	Recent advances in structures of starch-degrading enzymes encompass the substrate complex of starch debranching enzyme, the function of surface binding sites in plant isoamylase, details on individual steps in the mechanism of plant disproportionating enzyme and a self-stabilised conformation of amylose accommodated in the active site of plant alpha-glucosidase.	Starch	33-39	sucrase-isomaltase	Homo sapiens	346-363
27262298-1	2016	Bioactivity-guided fractionation of an aqueous methanolic extract of manufactured gambir product from Uncaria gambir with in vitro alpha-glucosidase inhibitory activity was performed to isolate a novel prenyl resorcinol derivative (1) together with seven known compounds, including two flavone glycosides (2, 3), three catechin analogues (4-6), and two simple phenolics (7, 8).	gambir	82-88	sucrase-isomaltase	Homo sapiens	131-148
27262298-1	2016	Bioactivity-guided fractionation of an aqueous methanolic extract of manufactured gambir product from Uncaria gambir with in vitro alpha-glucosidase inhibitory activity was performed to isolate a novel prenyl resorcinol derivative (1) together with seven known compounds, including two flavone glycosides (2, 3), three catechin analogues (4-6), and two simple phenolics (7, 8).	gambir	110-116	sucrase-isomaltase	Homo sapiens	131-148
27262298-1	2016	Bioactivity-guided fractionation of an aqueous methanolic extract of manufactured gambir product from Uncaria gambir with in vitro alpha-glucosidase inhibitory activity was performed to isolate a novel prenyl resorcinol derivative (1) together with seven known compounds, including two flavone glycosides (2, 3), three catechin analogues (4-6), and two simple phenolics (7, 8).	resorcinol	209-219	sucrase-isomaltase	Homo sapiens	131-148
27262298-4	2016	Among the compounds, novel compound 1, possessing an unprecedented spirocyclopropane ring in the molecule, showed the most potent alpha-glucosidase inhibitory activity in this assay.	spirocyclopropane	67-84	sucrase-isomaltase	Homo sapiens	130-147
27640062-26	2016	Alpha-glucosidase CT compared to IM showed a MD of -0.5 kg (95% CI -1.2 to 0.3); P = 0.26; 241 participants; 2 trials; low-quality evidence.Users of metformin CT (range 7% to 67% versus 5% to 16%), and alpha-glucosidase inhibitors CT (14% to 75% versus 4% to 35%) experienced more gastro-intestinal adverse effects compared to participants on IM.	Metformin	149-158	sucrase-isomaltase	Homo sapiens	0-17
27681250-6	2016	RESULTS: The ethyl acetate fraction had the greatest inhibitory effect on alpha-glucosidase, followed by n-butanol, sediment and residual aqua fractions (with the IC50 values of 0.26 mg/mL, 2.94 mg/mL, 3.02 mg/mL, and 5.24 mg/mL, respectively), mainly due to the high content of polyphenols.	ethyl acetate	13-26	sucrase-isomaltase	Homo sapiens	74-91
27681250-7	2016	Among the eight subfractions (QEF1-8) isolated from the ethyl acetate fraction, QEF8 fraction showed the highest alpha-glucosidase inhibitory potential in a competitive inhibitory manner (the K i value of 77.10 mug/mL).	ethyl acetate	56-69	sucrase-isomaltase	Homo sapiens	113-130
27182738-1	2016	A formal enantioselective synthesis of nectrisine, a potent alpha-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation, and cyclization.	nectrisine	39-49	sucrase-isomaltase	Homo sapiens	60-77
29870608-4	2016	Cytotoxic activity was assessed by means of human cancer cell lines (MCF-7 and HeLa), alpha-glucosidase inhibition was determined by colorimetric assay using p-Nitrophenyl a-D-glucopyranoside (PNPG) as a substrate.	p-nitrophenyl a-d-glucopyranoside	158-191	sucrase-isomaltase	Homo sapiens	86-103
27278405-8	2016	Consistent with this, the polyphenol components of the PFRF inhibited alpha-amylase (green tea, strawberry, blackberry and blackcurrant) and alpha-glucosidase (green tea) activities in vitro.	Polyphenols	26-36	sucrase-isomaltase	Homo sapiens	141-158
27454418-1	2016	BACKGROUND: alpha-amylase and alpha-glucosidase digest the carbohydrates and increase the postprandial glucose level in diabetic patients.	Carbohydrates	59-72	sucrase-isomaltase	Homo sapiens	30-47
27454418-1	2016	BACKGROUND: alpha-amylase and alpha-glucosidase digest the carbohydrates and increase the postprandial glucose level in diabetic patients.	Glucose	103-110	sucrase-isomaltase	Homo sapiens	30-47
27454418-8	2016	RESULTS: The protein extract from both MCC and MCM inhibited the activity of alpha-amylase and alpha-glucosidase through competitive inhibition, which was on par with Acarbose as indicated by in vitro percentage of inhibition (66 to 69 %) and IC50 (0.26 to 0.29 mg/ml).	Acarbose	167-175	sucrase-isomaltase	Homo sapiens	95-112
27060243-5	2016	Soluble protein and carbohydrate at mesotherm was 2.63-folds as that at microtherm due to higher activities of protease and alpha-glucosidase, guaranteeing efficient substrates to produce SCFAs.	Carbohydrates	20-32	sucrase-isomaltase	Homo sapiens	124-141
27549567-3	2016	Analyses of fluorescence and circular dichroism spectra indicated that the formation of the morin-alpha-glucosidase complex was driven mainly by hydrophobic forces and hydrogen bonding, and caused the conformational changes of alpha-glucosidase.	Hydrogen	168-176	sucrase-isomaltase	Homo sapiens	98-115
27549567-3	2016	Analyses of fluorescence and circular dichroism spectra indicated that the formation of the morin-alpha-glucosidase complex was driven mainly by hydrophobic forces and hydrogen bonding, and caused the conformational changes of alpha-glucosidase.	Hydrogen	168-176	sucrase-isomaltase	Homo sapiens	227-244
27489132-0	2016	Organocatalyzed Novel Synthetic Methodology for Highly Functionalized Piperidines as Potent alpha-Glucosidase Inhibitors.	Piperidines	70-81	sucrase-isomaltase	Homo sapiens	92-109
27489132-4	2016	The synthesized piperidines were screened against alpha-glucosidase inhibition, which revealed that these compounds were very active inhibitors, and some of the compounds showed even better inhibition than the reference compound, at low micromolar concentrations.	Piperidines	16-27	sucrase-isomaltase	Homo sapiens	50-67
27325449-0	2016	Hydrophobic substituents increase the potency of salacinol, a potent alpha-glucosidase inhibitor from Ayurvedic traditional medicine "Salacia".	salacinol	49-58	sucrase-isomaltase	Homo sapiens	69-86
27170557-7	2016	Specifically, berry extracts and anthocyanins inhibit the activities of pancreatic alpha-amylase and alpha-glucosidase in the gut lumen, and interact with intestinal sugar transporters, sodium-dependent glucose transporter 1 and GLUT2, to reduce the rate of glucose uptake into the circulation.	Anthocyanins	33-45	sucrase-isomaltase	Homo sapiens	101-118
27446235-2	2016	As part of a search for biologically active compounds with reduction of the rate of glucose absorption, a screening has been initiated to evaluate natural product extracts for the inhibition of enzyme alpha-glucosidase.	Glucose	84-91	sucrase-isomaltase	Homo sapiens	201-218
27446235-3	2016	A n-hexane extract of the bark of M. mekongensis showed strong alpha-glucosidase inhibitory activity with IC50 value of 1.71 microg/mL.	n-hexane	2-10	sucrase-isomaltase	Homo sapiens	63-80
27446235-9	2016	CONCLUSIONS: These results suggested that the traditional use of the bark of M. mekongensis for the treatment of diabetes diseases in Vietnam may be attributable to the alpha-glucosidase inhibitory activity of its steroid and cycloartane constituents.	Steroids	214-221	sucrase-isomaltase	Homo sapiens	169-186
27446235-9	2016	CONCLUSIONS: These results suggested that the traditional use of the bark of M. mekongensis for the treatment of diabetes diseases in Vietnam may be attributable to the alpha-glucosidase inhibitory activity of its steroid and cycloartane constituents.	cycloartane	226-237	sucrase-isomaltase	Homo sapiens	169-186
27149363-0	2016	Synthesis, molecular docking and alpha-glucosidase inhibition of 5-aryl-2-(6"-nitrobenzofuran-2"-yl)-1,3,4-oxadiazoles.	5-aryl-2-(6"-nitrobenzofuran-2"-yl)-1,3,4-oxadiazoles	65-118	sucrase-isomaltase	Homo sapiens	33-50
27177827-0	2016	Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent alpha-glucosidase inhibitors.	1,2,4-triazine	45-59	sucrase-isomaltase	Homo sapiens	107-124
27177827-0	2016	Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent alpha-glucosidase inhibitors.	carbazole	80-89	sucrase-isomaltase	Homo sapiens	107-124
27177827-1	2016	A new series of 1,2,4-triazine derivatives bearing carbazole moiety 7a-7p were designed, synthesized, and evaluated for their alpha-glucosidase inhibitory activity.	1,2,4-triazine	16-30	sucrase-isomaltase	Homo sapiens	126-143
27177827-2	2016	The majority of the screened compounds displayed potent alpha-glucosidase inhibitory activity, with IC50 values in the range of 4.27+-0.07-47.75+-0.25muM as compared to the standard drug acarbose.	Acarbose	187-195	sucrase-isomaltase	Homo sapiens	56-73
27177827-6	2016	This study showed these 1,2,4-triazine derivatives bearing carbazole moiety as a new class of alpha-glucosidase inhibitors.	1,2,4-triazine	24-38	sucrase-isomaltase	Homo sapiens	94-111
27177827-6	2016	This study showed these 1,2,4-triazine derivatives bearing carbazole moiety as a new class of alpha-glucosidase inhibitors.	carbazole	59-68	sucrase-isomaltase	Homo sapiens	94-111
27149363-1	2016	Twenty derivatives of 5-aryl-2-(6"-nitrobenzofuran-2"-yl)-1,3,4-oxadiazoles (1-20) were synthesized and evaluated for their alpha-glucosidase inhibitory activities.	5-aryl-2-(6"-nitrobenzofuran-2"-yl)-1,3,4-oxadiazoles	22-75	sucrase-isomaltase	Homo sapiens	124-141
27149363-3	2016	Current study explores the alpha-glucosidase inhibition of a hybrid class of compounds of oxadiazole and benzofurans.	Oxadiazoles	90-100	sucrase-isomaltase	Homo sapiens	27-44
27149363-3	2016	Current study explores the alpha-glucosidase inhibition of a hybrid class of compounds of oxadiazole and benzofurans.	Benzofurans	105-116	sucrase-isomaltase	Homo sapiens	27-44
26993530-0	2016	Effects of the ultra-high pressure on structure and alpha-glucosidase inhibition of polysaccharide from Astragalus.	Polysaccharides	84-98	sucrase-isomaltase	Homo sapiens	52-69
26690849-0	2016	Triterpene saponins with alpha-glucosidase inhibition and cytotoxic activity from the leaves of Schefflera sessiliflora.	triterpene saponins	0-19	sucrase-isomaltase	Homo sapiens	25-42
27145787-0	2016	Effect of Cadmium Ion on alpha-Glucosidase: An Inhibition Kinetics and Molecular Dynamics Simulation Integration Study.	Cadmium	10-17	sucrase-isomaltase	Homo sapiens	25-42
27145787-1	2016	alpha-Glucosidase is a critical metabolic enzyme that produces glucose molecules by catalyzing carbohydrates.	Glucose	63-70	sucrase-isomaltase	Homo sapiens	0-17
27145787-1	2016	alpha-Glucosidase is a critical metabolic enzyme that produces glucose molecules by catalyzing carbohydrates.	Carbohydrates	95-108	sucrase-isomaltase	Homo sapiens	0-17
26960032-0	2016	Identification of PTP1B and alpha-Glucosidase Inhibitory Serrulatanes from Eremophila spp.	serrulatanes	57-69	sucrase-isomaltase	Homo sapiens	28-45
26774085-0	2016	A fluorescence resonance energy transfer (FRET) based "Turn-On" nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxide nanosheet architecture and application to alpha-glucosidase inhibitor screening.	Nitrogen	96-104	sucrase-isomaltase	Homo sapiens	194-211
26774085-0	2016	A fluorescence resonance energy transfer (FRET) based "Turn-On" nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxide nanosheet architecture and application to alpha-glucosidase inhibitor screening.	Carbon	111-117	sucrase-isomaltase	Homo sapiens	194-211
26774085-0	2016	A fluorescence resonance energy transfer (FRET) based "Turn-On" nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxide nanosheet architecture and application to alpha-glucosidase inhibitor screening.	HCoO2	132-151	sucrase-isomaltase	Homo sapiens	194-211
26774085-7	2016	With hydrolysis of AAG by alpha-glucosidase, ascorbic acids (AA) were released that can rapidly reduce CoOOH nanoflakes to Co(2+), and then FRET was stopped accompanying with the fluorescence recovery of CDs.	Ascorbic Acid	45-59	sucrase-isomaltase	Homo sapiens	26-43
26774085-7	2016	With hydrolysis of AAG by alpha-glucosidase, ascorbic acids (AA) were released that can rapidly reduce CoOOH nanoflakes to Co(2+), and then FRET was stopped accompanying with the fluorescence recovery of CDs.	Cobalt(2+)	123-129	sucrase-isomaltase	Homo sapiens	26-43
26774085-7	2016	With hydrolysis of AAG by alpha-glucosidase, ascorbic acids (AA) were released that can rapidly reduce CoOOH nanoflakes to Co(2+), and then FRET was stopped accompanying with the fluorescence recovery of CDs.	Cadmium	204-207	sucrase-isomaltase	Homo sapiens	26-43
27088891-6	2016	Among them, luteolin (2), eriodictyol (5), ethyl rosmarinate (13), and clinopodic acids B (14) were proved to be potent alpha-glucosidase inhibitors with IC50 value ranging from 0.6 to 2.0 mum.	Luteolin	12-20	sucrase-isomaltase	Homo sapiens	120-137
27088891-6	2016	Among them, luteolin (2), eriodictyol (5), ethyl rosmarinate (13), and clinopodic acids B (14) were proved to be potent alpha-glucosidase inhibitors with IC50 value ranging from 0.6 to 2.0 mum.	eriodictyol	26-37	sucrase-isomaltase	Homo sapiens	120-137
27088891-6	2016	Among them, luteolin (2), eriodictyol (5), ethyl rosmarinate (13), and clinopodic acids B (14) were proved to be potent alpha-glucosidase inhibitors with IC50 value ranging from 0.6 to 2.0 mum.	ETHYL ROSMARINATE	43-60	sucrase-isomaltase	Homo sapiens	120-137
27088891-6	2016	Among them, luteolin (2), eriodictyol (5), ethyl rosmarinate (13), and clinopodic acids B (14) were proved to be potent alpha-glucosidase inhibitors with IC50 value ranging from 0.6 to 2.0 mum.	clinopodic acids b	71-89	sucrase-isomaltase	Homo sapiens	120-137
27162343-0	2016	Taste cell-expressed alpha-glucosidase enzymes contribute to gustatory responses to disaccharides.	Disaccharides	84-97	sucrase-isomaltase	Homo sapiens	21-38
30381790-0	2016	Bioactivity-guided isolation and purification of alpha-glucosidase inhibitor, 6-O-D-glycosides, from Tinta Cao grape pomace.	6-o-d-glycosides	78-94	sucrase-isomaltase	Homo sapiens	49-66
30381790-2	2016	One active alpha-glucosidase inhibitor and one new natural product determined as 6-O-(p-coumaroyl)-D-glucopyranoside and methyl 6-O-(p-coumaroyl)-beta-D-galactopyranoside, respectively, were isolated from GPE that were previously shown to potently inhibit alpha-glucosidase.	6-o-(p-coumaroyl)-d-glucopyranoside	81-116	sucrase-isomaltase	Homo sapiens	11-28
30381790-2	2016	One active alpha-glucosidase inhibitor and one new natural product determined as 6-O-(p-coumaroyl)-D-glucopyranoside and methyl 6-O-(p-coumaroyl)-beta-D-galactopyranoside, respectively, were isolated from GPE that were previously shown to potently inhibit alpha-glucosidase.	methyl 6-o-(p-coumaroyl)-beta-d-galactopyranoside	121-170	sucrase-isomaltase	Homo sapiens	11-28
26960032-8	2016	This is the first report of serrulatane-type diterpenoids as potential alpha-glucosidase and/or PTP1B inhibitors.	serrulatane	28-39	sucrase-isomaltase	Homo sapiens	71-88
26960032-8	2016	This is the first report of serrulatane-type diterpenoids as potential alpha-glucosidase and/or PTP1B inhibitors.	Diterpenes	45-57	sucrase-isomaltase	Homo sapiens	71-88
26974355-0	2016	Synthesis of water soluble glycosides of pentacyclic dihydroxytriterpene carboxylic acids as inhibitors of alpha-glucosidase.	Water	13-18	sucrase-isomaltase	Homo sapiens	107-124
27104505-7	2016	The partially etherified analogs 5"-hydroxy-2,3",4-trimethoxystilbene and 3",5"-dihydroxy-2,4-dimethoxystilbene demonstrated promising anti-herpetic and DNA protective activities, offering new leads for neuropreventive agent research, whereas 5"-hydroxy-2,3",4,-triisopropoxystilbene displayed anti-alpha-glucosidase effects, providing a new lead molecule for anti-diabetic drug development.	5"-hydroxy-2,3",4-trimethoxystilbene	33-69	sucrase-isomaltase	Homo sapiens	299-316
27104505-7	2016	The partially etherified analogs 5"-hydroxy-2,3",4-trimethoxystilbene and 3",5"-dihydroxy-2,4-dimethoxystilbene demonstrated promising anti-herpetic and DNA protective activities, offering new leads for neuropreventive agent research, whereas 5"-hydroxy-2,3",4,-triisopropoxystilbene displayed anti-alpha-glucosidase effects, providing a new lead molecule for anti-diabetic drug development.	3",5"-dihydroxy-2,4-dimethoxystilbene	74-111	sucrase-isomaltase	Homo sapiens	299-316
26972921-0	2016	A concise synthesis and evaluation of new malonamide derivatives as potential alpha-glucosidase inhibitors.	malonamide	42-52	sucrase-isomaltase	Homo sapiens	78-95
26972921-3	2016	Result showed that most of malonamide derivatives were identified as a potent inhibitors of alpha-glucosidase enzyme.	malonamide	27-37	sucrase-isomaltase	Homo sapiens	92-109
27015084-0	2016	Highly Diastereoselective Route to alpha-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol.	1,4-dideoxy-1,4-((2,3,4,5,6-pentahydroxyhexyl)episulfoniumylidene)arabinitol	82-95	sucrase-isomaltase	Homo sapiens	35-52
26974355-0	2016	Synthesis of water soluble glycosides of pentacyclic dihydroxytriterpene carboxylic acids as inhibitors of alpha-glucosidase.	Glycosides	27-37	sucrase-isomaltase	Homo sapiens	107-124
26974355-0	2016	Synthesis of water soluble glycosides of pentacyclic dihydroxytriterpene carboxylic acids as inhibitors of alpha-glucosidase.	pentacyclic dihydroxytriterpene carboxylic acids	41-89	sucrase-isomaltase	Homo sapiens	107-124
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	bis-disaccharide glycosides	83-110	sucrase-isomaltase	Homo sapiens	42-59
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	bis-disaccharide glycosides	83-110	sucrase-isomaltase	Homo sapiens	169-186
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	triterpene acids	114-130	sucrase-isomaltase	Homo sapiens	42-59
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	triterpene acids	114-130	sucrase-isomaltase	Homo sapiens	169-186
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	Water	148-153	sucrase-isomaltase	Homo sapiens	42-59
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	bis-monosaccharide glycosides	218-247	sucrase-isomaltase	Homo sapiens	42-59
26920798-4	2016	In alpha-glucosidase assay, compound 9 in Schiff base form and compound 22 in ester form show strong inhibition against alpha-glucosidase with IC50 value of 46.81muM and 83.76muM, respectively.	Esters	78-83	sucrase-isomaltase	Homo sapiens	120-137
29200746-4	2016	Apart from the well-known action of decreasing postprandial glucose sugar by inhibiting alpha-glucosidase and alpha-pancreatic amylase, it also inhibits aldose reductase which otherwise results in microvascular complications.	Glucose	60-67	sucrase-isomaltase	Homo sapiens	88-105
29200746-4	2016	Apart from the well-known action of decreasing postprandial glucose sugar by inhibiting alpha-glucosidase and alpha-pancreatic amylase, it also inhibits aldose reductase which otherwise results in microvascular complications.	Sugars	68-73	sucrase-isomaltase	Homo sapiens	88-105
26894559-0	2016	Synthesis, alpha-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles.	2-aryl-7-methylbenzimidazoles	77-106	sucrase-isomaltase	Homo sapiens	11-28
26593489-5	2016	Some monoterpenes inhibited alpha-amylase and alpha-glucosidase activity and stimulated glucose uptake and lipolysis.	Monoterpenes	5-17	sucrase-isomaltase	Homo sapiens	46-63
26894559-1	2016	Benzimidazole analogs 1-27 were synthesized, characterized by EI-MS and (1)HNMR and their alpha-glucosidase inhibitory activities were found out experimentally.	benzimidazole	0-13	sucrase-isomaltase	Homo sapiens	90-107
26917220-0	2016	Synthesis of 3-acyloxyxanthone derivatives as alpha-glucosidase inhibitors: A further insight into the 3-substituents" effect.	3-acyloxyxanthone	13-30	sucrase-isomaltase	Homo sapiens	46-63
26917220-2	2016	In this paper, a series of novel 3-arylacyloxyxanthone derivatives 2a-p were synthesized and evaluated for their biological activities toward alpha-glucosidase.	3-arylacyloxyxanthone	33-54	sucrase-isomaltase	Homo sapiens	142-159
26917220-2	2016	In this paper, a series of novel 3-arylacyloxyxanthone derivatives 2a-p were synthesized and evaluated for their biological activities toward alpha-glucosidase.	2a-p	67-71	sucrase-isomaltase	Homo sapiens	142-159
26917220-5	2016	These results suggest that addition of aromatic moieties by esterification at the 3-OH of the parent 1,3-dihydroxylxanthone is an efficient way to increase the inhibition against alpha-glucosidase.	1,3-dihydroxylxanthone	101-123	sucrase-isomaltase	Homo sapiens	179-196
26917220-11	2016	The new developed 3-arylacyloxyxanthone derivatives probably bind with alpha-glucosidase in an allosteric site different from traditional multi-hydroxylxanthones.	3-arylacyloxyxanthone	18-39	sucrase-isomaltase	Homo sapiens	71-88
26917220-11	2016	The new developed 3-arylacyloxyxanthone derivatives probably bind with alpha-glucosidase in an allosteric site different from traditional multi-hydroxylxanthones.	hydroxylxanthones	144-161	sucrase-isomaltase	Homo sapiens	71-88
26920798-2	2016	But there is no report about anisodamine with alpha-glucosidase inhibitory activity.	anisodamine	29-40	sucrase-isomaltase	Homo sapiens	46-63
26920798-3	2016	In order to find novel alpha-glucosidase inhibitors, a series of alpha-substituted arylacetates derivatives have been synthesized based on the active unit of anisodamine.	alpha-substituted arylacetates	65-95	sucrase-isomaltase	Homo sapiens	23-40
26920798-3	2016	In order to find novel alpha-glucosidase inhibitors, a series of alpha-substituted arylacetates derivatives have been synthesized based on the active unit of anisodamine.	anisodamine	158-169	sucrase-isomaltase	Homo sapiens	23-40
26920798-4	2016	In alpha-glucosidase assay, compound 9 in Schiff base form and compound 22 in ester form show strong inhibition against alpha-glucosidase with IC50 value of 46.81muM and 83.76muM, respectively.	Schiff Bases	42-53	sucrase-isomaltase	Homo sapiens	3-20
26920798-4	2016	In alpha-glucosidase assay, compound 9 in Schiff base form and compound 22 in ester form show strong inhibition against alpha-glucosidase with IC50 value of 46.81muM and 83.76muM, respectively.	Schiff Bases	42-53	sucrase-isomaltase	Homo sapiens	120-137
26920798-4	2016	In alpha-glucosidase assay, compound 9 in Schiff base form and compound 22 in ester form show strong inhibition against alpha-glucosidase with IC50 value of 46.81muM and 83.76muM, respectively.	Esters	78-83	sucrase-isomaltase	Homo sapiens	3-20
26964016-0	2016	Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as alpha-glucosidase inhibitors.	coumarin	53-61	sucrase-isomaltase	Homo sapiens	86-103
26964016-0	2016	Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as alpha-glucosidase inhibitors.	Thiazoles	62-70	sucrase-isomaltase	Homo sapiens	86-103
26840363-0	2016	Design, synthesis and biological evaluation of 3"-benzylated analogs of 3"-epi-neoponkoranol as potent alpha-glucosidase inhibitors.	3"-epi-neoponkoranol	72-92	sucrase-isomaltase	Homo sapiens	103-120
26960205-0	2016	Antioxidant Activity and alpha-Glucosidase Inhibitory Activities of the Polycondensate of Catechin with Glyoxylic Acid.	Catechin	90-98	sucrase-isomaltase	Homo sapiens	25-42
26960205-0	2016	Antioxidant Activity and alpha-Glucosidase Inhibitory Activities of the Polycondensate of Catechin with Glyoxylic Acid.	glyoxylic acid	104-118	sucrase-isomaltase	Homo sapiens	25-42
26960205-1	2016	In order to investigate polymeric flavonoids, the polycondensate of catechin with glyoxylic acid (PCG) was prepared and its chemically antioxidant, cellular antioxidant (CAA) and alpha-glucosidase inhibitory activities were evaluated.	pcg	98-101	sucrase-isomaltase	Homo sapiens	179-196
26960205-3	2016	In addition, PCG had very high alpha-glucosidase inhibitory activities (IC50 value, 2.59 mug/mL) in comparison to catechin (IC50 value, 239.27 mug/mL).	pcg	13-16	sucrase-isomaltase	Homo sapiens	31-48
26960205-5	2016	The enhanced CAA and alpha-glucosidase inhibitor activities of PCG could be due to catechin polymerization enhancing the binding capacity to the cellular membrane and enzymes.	pcg	63-66	sucrase-isomaltase	Homo sapiens	21-38
26960205-5	2016	The enhanced CAA and alpha-glucosidase inhibitor activities of PCG could be due to catechin polymerization enhancing the binding capacity to the cellular membrane and enzymes.	Catechin	83-91	sucrase-isomaltase	Homo sapiens	21-38
26840363-2	2016	Biological evaluation of these compounds revealed that sulfonium salts attached with ortho-substituted benzyl groups showed best alpha-glucosidase inhibitory activities.	sulfonium salts	55-70	sucrase-isomaltase	Homo sapiens	129-146
26840363-7	2016	The enzyme kinetic studies showed a fully competitive inhibition of these sulfonium salts on each alpha-glucosidase.	sulfonium salts	74-89	sucrase-isomaltase	Homo sapiens	98-115
26764561-3	2016	Compared with HT, HPH-DMDC treatment resulted in a higher degree of retention in total phenolics, and alpha-glucosidase inhibitory activity, although the treatment led to higher losses in cyanidin 3-glucoside, cyanidin 3-rutinoside, and antioxidant capacity.	dimethyl pyrocarbonate	22-26	sucrase-isomaltase	Homo sapiens	102-119
26724817-0	2016	Inhibitory evaluation of oligonol on alpha-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and beta-secretase 1 related to diabetes and Alzheimer"s disease.	oligonol	25-33	sucrase-isomaltase	Homo sapiens	37-54
26724817-2	2016	This study investigates the anti-diabetic activities of oligonol via alpha-glucosidase and human recombinant protein tyrosine phosphatase 1B (PTP1B) assays, as well as its anti-Alzheimer activities by evaluating the ability of this compound to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).	oligonol	56-64	sucrase-isomaltase	Homo sapiens	69-86
26724817-3	2016	Oligonol exhibited potent concentration-dependent anti-diabetic activities by inhibiting alpha-glucosidase and PTP1B with IC50 values of 23.14 microg/mL and 1.02 microg/mL, respectively.	oligonol	0-8	sucrase-isomaltase	Homo sapiens	89-106
26724817-4	2016	Moreover, a kinetics study revealed that oligonol inhibited alpha-glucosidase (K i = 22.36) and PTP1B (K i = 8.51) with characteristics typical of a mixed inhibitor.	oligonol	41-49	sucrase-isomaltase	Homo sapiens	60-77
26362113-0	2016	Synthesis, In vitro and Docking Studies of New Flavone Ethers as alpha-Glucosidase Inhibitors.	flavone ethers	47-61	sucrase-isomaltase	Homo sapiens	65-82
26362113-1	2016	We report herein the synthesis, alpha-glucosidase inhibition and docking studies for a series of 3-15 new flavones.	Flavones	106-114	sucrase-isomaltase	Homo sapiens	32-49
27051594-9	2016	In the lysosomes, glycogen degradation is catalyzed by alpha-glucosidase.	Glycogen	18-26	sucrase-isomaltase	Homo sapiens	55-72
26760440-0	2016	Quantitation of Alpha-Glucosidase Activity Using Fluorinated Carbohydrate Array and MALDI-TOF-MS. Quantitation of alpha-glucosidase (alpha-GD) activity is of significance to diagnosis of many diseases including Pompe disease and type II diabetes.	Carbohydrates	61-73	sucrase-isomaltase	Homo sapiens	16-33
26760440-0	2016	Quantitation of Alpha-Glucosidase Activity Using Fluorinated Carbohydrate Array and MALDI-TOF-MS. Quantitation of alpha-glucosidase (alpha-GD) activity is of significance to diagnosis of many diseases including Pompe disease and type II diabetes.	Carbohydrates	61-73	sucrase-isomaltase	Homo sapiens	114-131
26760440-0	2016	Quantitation of Alpha-Glucosidase Activity Using Fluorinated Carbohydrate Array and MALDI-TOF-MS. Quantitation of alpha-glucosidase (alpha-GD) activity is of significance to diagnosis of many diseases including Pompe disease and type II diabetes.	Carbohydrates	61-73	sucrase-isomaltase	Homo sapiens	133-141
26760440-1	2016	We report here a new method to determine alpha-GD activity using matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF) mass spectrometry (MS) in combination with carbohydrate microarray and affinity surface chemistry.	Carbohydrates	181-193	sucrase-isomaltase	Homo sapiens	41-49
26725952-0	2016	Synthesis, in vitro and computational studies of 1,4-disubstituted 1,2,3-triazoles as potential alpha-glucosidase inhibitors.	1,4-disubstituted	49-66	sucrase-isomaltase	Homo sapiens	96-113
26474001-0	2016	Acarbose, the alpha-glucosidase inhibitor, attenuates the blood pressure and splanchnic blood flow responses to meal in elderly patients with postprandial hypotension concomitant with abnormal glucose metabolism.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	14-31
26725952-0	2016	Synthesis, in vitro and computational studies of 1,4-disubstituted 1,2,3-triazoles as potential alpha-glucosidase inhibitors.	1,2,3-triazoles	67-82	sucrase-isomaltase	Homo sapiens	96-113
26725952-2	2016	These synthesized triazoles were subjected to enzymatic assay which showed promising activity against alpha-glucosidase; 1-(2-cyano-4-nitrophenyl)-4-(1-hydroxycyclohexyl)-1H-1,2,3-triazole 3m being the most active members of the library.	Triazoles	18-27	sucrase-isomaltase	Homo sapiens	102-119
26725952-2	2016	These synthesized triazoles were subjected to enzymatic assay which showed promising activity against alpha-glucosidase; 1-(2-cyano-4-nitrophenyl)-4-(1-hydroxycyclohexyl)-1H-1,2,3-triazole 3m being the most active members of the library.	1-(2-cyano-4-nitrophenyl)-4-(1-hydroxycyclohexyl)-1h-1,2,3-triazole	121-188	sucrase-isomaltase	Homo sapiens	102-119
26725952-3	2016	Molecular docking studies of these triazoles with the homology-modeled alpha-glucosidase protein were also performed to delineate ligand-protein interactions at molecular level which suggested that Phe157, Arg312 and His279 are the major interacting residues in the biding site of the protein and may have a significant role in the inhibition of enzyme"s function.	Triazoles	35-44	sucrase-isomaltase	Homo sapiens	71-88
26744303-0	2016	Inhibition of alpha-glucosidase by vitamin D3 and the effect of vitamins B1 and B2.	Cholecalciferol	35-45	sucrase-isomaltase	Homo sapiens	14-31
26744303-1	2016	alpha-Glucosidase is a vital enzyme in carbohydrate metabolism.	Carbohydrates	39-51	sucrase-isomaltase	Homo sapiens	0-17
26744303-3	2016	The inhibitory effect of vitamin D3 on alpha-glucosidase as well as its mechanism of action was investigated in this work.	Cholecalciferol	25-35	sucrase-isomaltase	Homo sapiens	39-56
26744303-4	2016	The results showed that vitamin D3 exhibited stronger inhibition on alpha-glucosidase than acarbose with the IC50 value of 1.28 x 10(-4) mol L(-1), and the inhibition was a mixed-type mechanism through a multiphase kinetic process.	Cholecalciferol	24-34	sucrase-isomaltase	Homo sapiens	68-85
26744303-6	2016	Vitamin D3 interacted with alpha-glucosidase by hydrophobic interactions, and molecular docking further verified that the inhibitor inserted into the active site pocket of alpha-glucosidase and interacted with the amino residues, which induced the rearrangement and conformational changes of alpha-glucosidase, and might move to cover the active pocket, hindering the binding of the substrate leading to the inhibition of the enzyme activity.	Cholecalciferol	0-10	sucrase-isomaltase	Homo sapiens	27-44
26744303-6	2016	Vitamin D3 interacted with alpha-glucosidase by hydrophobic interactions, and molecular docking further verified that the inhibitor inserted into the active site pocket of alpha-glucosidase and interacted with the amino residues, which induced the rearrangement and conformational changes of alpha-glucosidase, and might move to cover the active pocket, hindering the binding of the substrate leading to the inhibition of the enzyme activity.	Cholecalciferol	0-10	sucrase-isomaltase	Homo sapiens	172-189
26744303-6	2016	Vitamin D3 interacted with alpha-glucosidase by hydrophobic interactions, and molecular docking further verified that the inhibitor inserted into the active site pocket of alpha-glucosidase and interacted with the amino residues, which induced the rearrangement and conformational changes of alpha-glucosidase, and might move to cover the active pocket, hindering the binding of the substrate leading to the inhibition of the enzyme activity.	Cholecalciferol	0-10	sucrase-isomaltase	Homo sapiens	172-189
26744303-7	2016	Moreover, it was found that vitamin D3 combined with vitamin B1 or vitamin B2 exhibited significant synergistic effects on inhibition of alpha-glucosidase.	Cholecalciferol	28-38	sucrase-isomaltase	Homo sapiens	137-154
26744303-7	2016	Moreover, it was found that vitamin D3 combined with vitamin B1 or vitamin B2 exhibited significant synergistic effects on inhibition of alpha-glucosidase.	Thiamine	53-63	sucrase-isomaltase	Homo sapiens	137-154
26744303-7	2016	Moreover, it was found that vitamin D3 combined with vitamin B1 or vitamin B2 exhibited significant synergistic effects on inhibition of alpha-glucosidase.	Riboflavin	67-77	sucrase-isomaltase	Homo sapiens	137-154
26575305-6	2016	Glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, and alpha-glucosidase inhibitors predominantly reduce postprandial plasma glucose levels.	Glucose	152-159	sucrase-isomaltase	Homo sapiens	82-99
26744303-8	2016	This study has provided new insights into the role of vitamin D3 in inhibiting alpha-glucosidase catalysis and offered useful information on the dietary recommendation of vitamin D3 for the treatment of type 2 diabetes.	Cholecalciferol	54-64	sucrase-isomaltase	Homo sapiens	79-96
26575305-7	2016	Among all of these, alpha-glucosidase inhibitors reduces postprandial hyperglycemia by delaying carbohydrate absorption from the intestine and this mechanism provides glycemic control without exacerbating coexisting cerebrovascular risk factors.	Carbohydrates	96-108	sucrase-isomaltase	Homo sapiens	20-37
25962377-2	2016	p-Nitrophenol, the hydrolysis product of the alpha-glucosidase reaction, could quench the fluorescence of beta-cyclodextrin-coated quantum dots via an electron transfer process, leading to fluorescence turn-off, whereas the fluorescence of the system turned on in the presence of alpha-glucosidase inhibitors.	4-nitrophenol	0-13	sucrase-isomaltase	Homo sapiens	280-297
25962377-2	2016	p-Nitrophenol, the hydrolysis product of the alpha-glucosidase reaction, could quench the fluorescence of beta-cyclodextrin-coated quantum dots via an electron transfer process, leading to fluorescence turn-off, whereas the fluorescence of the system turned on in the presence of alpha-glucosidase inhibitors.	betadex	106-123	sucrase-isomaltase	Homo sapiens	45-62
25962377-0	2016	Sensitive fluorimetric assays for alpha-glucosidase activity and inhibitor screening based on beta-cyclodextrin-coated quantum dots.	betadex	94-111	sucrase-isomaltase	Homo sapiens	34-51
25962377-1	2016	A fluorescence method was established for a alpha-glucosidase activity assay and inhibitor screening based on beta-cyclodextrin-coated quantum dots.	betadex	110-127	sucrase-isomaltase	Homo sapiens	44-61
25962377-2	2016	p-Nitrophenol, the hydrolysis product of the alpha-glucosidase reaction, could quench the fluorescence of beta-cyclodextrin-coated quantum dots via an electron transfer process, leading to fluorescence turn-off, whereas the fluorescence of the system turned on in the presence of alpha-glucosidase inhibitors.	betadex	106-123	sucrase-isomaltase	Homo sapiens	280-297
25962377-2	2016	p-Nitrophenol, the hydrolysis product of the alpha-glucosidase reaction, could quench the fluorescence of beta-cyclodextrin-coated quantum dots via an electron transfer process, leading to fluorescence turn-off, whereas the fluorescence of the system turned on in the presence of alpha-glucosidase inhibitors.	4-nitrophenol	0-13	sucrase-isomaltase	Homo sapiens	45-62
25962377-4	2016	Two alpha-glucosidase inhibitors, 2,4,6-tribromophenol and acarbose, were used to evaluate the feasibility of this screening model, and IC50 values of 24 muM and 0.55 mM were obtained respectively, which were lower than those previously reported.	2,4,6-tribromophenol	34-54	sucrase-isomaltase	Homo sapiens	4-21
25962377-4	2016	Two alpha-glucosidase inhibitors, 2,4,6-tribromophenol and acarbose, were used to evaluate the feasibility of this screening model, and IC50 values of 24 muM and 0.55 mM were obtained respectively, which were lower than those previously reported.	Acarbose	59-67	sucrase-isomaltase	Homo sapiens	4-21
27477661-0	2016	Synthesis and Biological Evaluation of 3-Benzylidene-4-chromanone Derivatives as Free Radical Scavengers and alpha-Glucosidase Inhibitors.	Isoflavones	39-65	sucrase-isomaltase	Homo sapiens	109-126
26633162-2	2016	The parent compound, DAB, did not show inhibition of human beta-glucocerebrosidase but showed moderate intestinal alpha-glucosidase inhibition; in contrast, extension of alpha-1-C-alkyl chain length gave a series of highly potent and selective inhibitors of the beta-glucocerebrosidase.	1,4-dideoxy-1,4-iminoarabinitol	21-24	sucrase-isomaltase	Homo sapiens	114-131
26751038-1	2016	Although alpha-glucosidase inhibitors (AGIs) are commonly used for controlling postprandial blood glucose, AGIs-induced liver injuries have been reported.	Glucose	98-105	sucrase-isomaltase	Homo sapiens	9-26
26742071-3	2016	Dietary polyphenols may inhibit alpha-amylase and alpha-glucosidase, inhibit glucose absorption in the intestine by sodium-dependent glucose transporter 1 (SGLT1), stimulate insulin secretion and reduce hepatic glucose output.	Polyphenols	8-19	sucrase-isomaltase	Homo sapiens	50-67
27477661-1	2016	A series of 3-benzylidene-4-chromanone derivatives (3-20) were synthesized and the structure-activity relationships for antioxidant and alpha-glucosidase inhibitory activities were evaluated.	Isoflavones	12-38	sucrase-isomaltase	Homo sapiens	136-153
27477661-5	2016	These data suggest that 3-benzylidene-4-chromanone derivatives, such as compound 18, may serve as the lead compound for the development of novel alpha-glucosidase inhibitors with antioxidant activity.	Isoflavones	24-50	sucrase-isomaltase	Homo sapiens	145-162
27073693-0	2016	Inhibition of Intestinal alpha-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone.	arabinoxylan mono- and oligosaccharides	82-121	sucrase-isomaltase	Homo sapiens	25-42
26212963-0	2016	Inhibitory kinetics and mechanism of kaempferol on alpha-glucosidase.	kaempferol	37-47	sucrase-isomaltase	Homo sapiens	51-68
26212963-2	2016	As a kind of potentially safer alpha-glucosidase inhibitor, flavonoids have attached much attention currently.	Flavonoids	60-70	sucrase-isomaltase	Homo sapiens	31-48
26212963-3	2016	In this study, kaempferol was found to show a notable inhibition activity on alpha-glucosidase in a mixed-type manner with IC50 value of (1.16 +- 0.04) x 10(-5) mol L(-1).	kaempferol	15-25	sucrase-isomaltase	Homo sapiens	77-94
26212963-4	2016	Analyses of fluorescence, circular dichroism and Fourier transform infrared spectra indicated that kaempferol bound to alpha-glucosidase with high affinity which was mainly driven by hydrogen bonds and van der Waals forces, and this binding resulted in conformational alteration of alpha-glucosidase.	kaempferol	99-109	sucrase-isomaltase	Homo sapiens	119-136
26212963-4	2016	Analyses of fluorescence, circular dichroism and Fourier transform infrared spectra indicated that kaempferol bound to alpha-glucosidase with high affinity which was mainly driven by hydrogen bonds and van der Waals forces, and this binding resulted in conformational alteration of alpha-glucosidase.	kaempferol	99-109	sucrase-isomaltase	Homo sapiens	282-299
26212963-4	2016	Analyses of fluorescence, circular dichroism and Fourier transform infrared spectra indicated that kaempferol bound to alpha-glucosidase with high affinity which was mainly driven by hydrogen bonds and van der Waals forces, and this binding resulted in conformational alteration of alpha-glucosidase.	Hydrogen	183-191	sucrase-isomaltase	Homo sapiens	119-136
26212963-6	2016	It was proposed that kaempferol may interact with some amino acid residues located within the active site of alpha-glucosidase, occupying the catalytic center of the enzyme to avoid the entrance of p-nitrophenyl-alpha-D-glucopyranoside and ultimately inhibiting the enzyme activity.	kaempferol	21-31	sucrase-isomaltase	Homo sapiens	109-126
26212963-6	2016	It was proposed that kaempferol may interact with some amino acid residues located within the active site of alpha-glucosidase, occupying the catalytic center of the enzyme to avoid the entrance of p-nitrophenyl-alpha-D-glucopyranoside and ultimately inhibiting the enzyme activity.	4-nitrophenyl alpha-glucoside	198-235	sucrase-isomaltase	Homo sapiens	109-126
27086810-0	2016	Postprandial Reactive Hypoglycemia Treated with a Low-dose Alpha-glucosidase Inhibitor: Voglibose May Suppress Oxidative Stress and Prevent Endothelial Dysfunction.	voglibose	88-97	sucrase-isomaltase	Homo sapiens	59-76
27086810-3	2016	The administration of low-dose voglibose, an alpha-glucosidase inhibitor (alpha-GI), improved the glucose fluctuations and inhibited hypoglycemic symptoms.	voglibose	31-40	sucrase-isomaltase	Homo sapiens	45-62
27150868-3	2016	We herein describe a case in which concurrent therapy with a low-carbohydrate diet using low-glycemic-index food and an alpha-glucosidase inhibitor, miglitol, very effectively ameliorated the postprandial fluctuations in the blood glucose and plasma insulin levels in a patient with reactive hypoglycemia due to late dumping syndrome following total gastrectomy.	Carbohydrates	65-77	sucrase-isomaltase	Homo sapiens	120-137
27150868-3	2016	We herein describe a case in which concurrent therapy with a low-carbohydrate diet using low-glycemic-index food and an alpha-glucosidase inhibitor, miglitol, very effectively ameliorated the postprandial fluctuations in the blood glucose and plasma insulin levels in a patient with reactive hypoglycemia due to late dumping syndrome following total gastrectomy.	Glucose	231-238	sucrase-isomaltase	Homo sapiens	120-137
27086787-1	2016	Acarbose, a well known and efficacious alpha-amylase and alpha-glucosidase inhibitor, is a postprandial acting antidiabetic drug.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	57-74
27073693-1	2016	The effect of feruloylated arabinoxylan mono- and oligosaccharides (FAXmo) on mammalian alpha-glucosidase and glucose transporters was investigated using human Caco-2 cells, rat intestinal acetone powder, and Xenopus laevis oocytes.	feruloylated arabinoxylan mono- and oligosaccharides	14-66	sucrase-isomaltase	Homo sapiens	88-105
27073693-1	2016	The effect of feruloylated arabinoxylan mono- and oligosaccharides (FAXmo) on mammalian alpha-glucosidase and glucose transporters was investigated using human Caco-2 cells, rat intestinal acetone powder, and Xenopus laevis oocytes.	faxmo	68-73	sucrase-isomaltase	Homo sapiens	88-105
26256322-4	2015	However, because pure glucose, or 2-DG, is directly absorbed in the proximal small intestine, we designed 2-DG containing maltooligosaccharides (2-DG-MOs) that can be used with a mild alpha-glucosidase inhibitor to attain an analytical method for determining location-specific delivery of glucose and its physiological effect.	maltooligosaccharides	122-143	sucrase-isomaltase	Homo sapiens	184-201
26201984-3	2015	Since alpha-glucosidase can specifically catalyze MNPs/pAPG into MNPs/pAP which has no binding capacity with PBA, the activity of both isolated and membrane bound enzyme can be well evaluated by using this proposed method.	4-phenylbutyric acid	109-112	sucrase-isomaltase	Homo sapiens	6-23
26152875-4	2015	In the present study, we examined the inhibitory activity of methanol extracts of different parts of 12 Angelica species against alpha-glucosidase, protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Methanol	61-69	sucrase-isomaltase	Homo sapiens	129-146
26152875-5	2015	The methanol extract of Angelica decursiva exhibited the highest inhibitory activities against alpha-glucosidase, PTP1B, AChE, and BChE and so was selected for further investigation.	Methanol	4-12	sucrase-isomaltase	Homo sapiens	95-112
26398141-0	2015	Evaluation of 2-indolcarbohydrazones as potent alpha-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions.	2-indolcarbohydrazone	14-36	sucrase-isomaltase	Homo sapiens	47-64
26398141-1	2015	2-Indolcarbohydrazones 1-28 were synthesized and evaluated for their alpha-glucosidase inhibitory potential.	2-indolcarbohydrazone	0-22	sucrase-isomaltase	Homo sapiens	69-86
26122626-4	2016	As association with lipid rafts influences the intracellular transport and the enzyme activities of sucrase-isomaltase and maltase-glucoamylase, these data explain reduced carbohydrate digestion in the intestinal lumen and delineate the effect of deficient cholesterol and sphingolipid homeostasis in development of gastrointestinal symptoms in NPC patients.	Carbohydrates	172-184	sucrase-isomaltase	Homo sapiens	100-118
26996014-0	2016	Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.	lupane	60-66	sucrase-isomaltase	Homo sapiens	14-31
26996014-0	2016	Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.	oleanane	68-76	sucrase-isomaltase	Homo sapiens	14-31
26996014-0	2016	Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.	ursane	78-84	sucrase-isomaltase	Homo sapiens	14-31
26996014-0	2016	Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.	dammarane	89-98	sucrase-isomaltase	Homo sapiens	14-31
26996014-0	2016	Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.	triterpenoids	99-112	sucrase-isomaltase	Homo sapiens	14-31
27405168-0	2016	[Synthesis, biological activity and molecular docking research of N-{[(4-oxo-thiochroman-3-yl)phenyl]-methyl}acetamide derivatives as alpha-glucosidase inhibitors].	n-{[(4-oxo-thiochroman-3-yl)phenyl]-methyl}acetamide	66-118	sucrase-isomaltase	Homo sapiens	134-151
27477734-1	2016	The aim of this study was to examine the effects of food thickeners on the pharmacodynamics of voglibose, an alpha-glucosidase inhibitor.	voglibose	95-104	sucrase-isomaltase	Homo sapiens	109-126
26432614-1	2015	Biscoumarin analogs 1-18 have been synthesized, characterized by EI-MS and (1)H NMR and evaluated for alpha-glucosidase inhibitory potential.	biscoumarin	0-11	sucrase-isomaltase	Homo sapiens	102-119
26432614-2	2015	All compounds showed variety of alpha-glucosidase inhibitory potential ranging in between 13.5+-0.39 and 104.62+-0.3muM when compared with standard acarbose having IC50 value 774.5+-1.94muM.	Acarbose	148-156	sucrase-isomaltase	Homo sapiens	32-49
25640970-0	2015	Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and alpha-glucosidase inhibition.	2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4h-1,2,4-triazol-4-yl]acetohydrazide	59-137	sucrase-isomaltase	Homo sapiens	176-193
26356422-0	2015	Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent alpha-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.	1-Deoxynojirimycin	10-26	sucrase-isomaltase	Homo sapiens	127-144
26256322-4	2015	However, because pure glucose, or 2-DG, is directly absorbed in the proximal small intestine, we designed 2-DG containing maltooligosaccharides (2-DG-MOs) that can be used with a mild alpha-glucosidase inhibitor to attain an analytical method for determining location-specific delivery of glucose and its physiological effect.	Deoxyglucose	106-110	sucrase-isomaltase	Homo sapiens	184-201
26256322-4	2015	However, because pure glucose, or 2-DG, is directly absorbed in the proximal small intestine, we designed 2-DG containing maltooligosaccharides (2-DG-MOs) that can be used with a mild alpha-glucosidase inhibitor to attain an analytical method for determining location-specific delivery of glucose and its physiological effect.	Molybdenum	150-153	sucrase-isomaltase	Homo sapiens	184-201
26307605-1	2015	OBJECTIVE: Acarbose, an alpha-glucosidase inhibitor, has been shown to have antineoplastic effects on colorectal cancer in biomarker studies.	Acarbose	11-19	sucrase-isomaltase	Homo sapiens	24-41
26129821-4	2015	Treatment of newly confluent Caco-2/15 cells with SAHA resulted in growth arrest, increased histone acetylation and up-regulation of the expression of intestine-specific genes such as those encoding sucrase-isomaltase, villin and the ion exchanger SLC26A3.	Vorinostat	50-54	sucrase-isomaltase	Homo sapiens	199-217
25970814-7	2015	RESULTS: In intention-to-treat analyses, there was no difference in the risk of any cardiovascular event among the add-on combination treatment groups, but significantly lower risks of acute myocardial infarction were found for the glinides plus metformin treatment group (crude hazard ratio 0.52, adjusted hazard ratio 0.39; 95% CI 0.20-0.75) and for the alpha-glucosidase inhibitors plus metformin treatment group (crude hazard ratio 0.63, adjusted hazard ratio 0.54; 95% CI 0.31-0.95).	glinides	232-240	sucrase-isomaltase	Homo sapiens	356-373
26162519-1	2015	A series of thiazole derivatives 1-21 were prepared, characterized by EI-MS and (1)H NMR and evaluated for alpha-glucosidase inhibitory potential.	Thiazoles	12-20	sucrase-isomaltase	Homo sapiens	107-124
26469191-6	2015	Moreover, the methanolic extracts of different mulberry cultivars showed disparate antioxidant and alpha-glucosidase inhibitory activities, and this discrepancy was mainly attributed to varying the anthocyanin content.	methanolic	14-24	sucrase-isomaltase	Homo sapiens	99-116
26344912-1	2015	Treatment of diabetes mellitus by oral alpha-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects.	Acarbose	93-101	sucrase-isomaltase	Homo sapiens	39-56
26344912-1	2015	Treatment of diabetes mellitus by oral alpha-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects.	miglitol	103-111	sucrase-isomaltase	Homo sapiens	39-56
26344912-1	2015	Treatment of diabetes mellitus by oral alpha-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects.	voglibose	116-125	sucrase-isomaltase	Homo sapiens	39-56
26351039-0	2015	Synthesis, alpha-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones.	Chalcones	126-135	sucrase-isomaltase	Homo sapiens	11-28
26351039-2	2015	The 3",5"-digeranylated chalcone (16) was identified as a new alpha-glucosidase inhibitor whose activity (IC50=0.90 muM) was 50-fold more than that of acarbose (IC50=51.32 muM).	3",5"-digeranylated chalcone	4-32	sucrase-isomaltase	Homo sapiens	62-79
26473832-6	2015	Flavonoid glucosides and acetophenone derivatives showed aldose reductase and alpha-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes.	flavonoid glucosides	0-20	sucrase-isomaltase	Homo sapiens	78-95
26473832-6	2015	Flavonoid glucosides and acetophenone derivatives showed aldose reductase and alpha-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes.	acetophenone	25-37	sucrase-isomaltase	Homo sapiens	78-95
26162519-0	2015	Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of alpha-glucosidase.	Thiazoles	64-72	sucrase-isomaltase	Homo sapiens	106-123
26543535-10	2015	CONCLUSIONS: Although natural substrates of glycosidase are polysaccharides, in the present study we successfully isolated novel peptide modulators of alpha-glucosidase.	Polysaccharides	60-75	sucrase-isomaltase	Homo sapiens	151-168
26471939-1	2015	BACKGROUND: Pompe disease is a rare autosomal recessive disorder caused by a deficiency of the lysosomal enzyme alpha-glucosidase responsible for degrading glycogen.	Glycogen	156-164	sucrase-isomaltase	Homo sapiens	112-129
26162519-2	2015	All twenty one derivatives showed good alpha-glucosidase inhibitory activity with IC50 value ranging between 18.23+-0.03 and 424.41+-0.94muM when compared with the standard acarbose (IC50, 38.25+-0.12muM).	Acarbose	173-181	sucrase-isomaltase	Homo sapiens	39-56
26162519-6	2015	Studies showed these thiazole analogs as a new class of alpha-glucosidase inhibitors.	Thiazoles	21-29	sucrase-isomaltase	Homo sapiens	56-73
26343100-3	2015	Inhibitors of carbohydrate-hydrolyzing enzymes (such as alpha-glucosidase and alpha-amylase) offer an effective strategy to regulate/prevent hyperglycemia by controlling starch breakdown.	Carbohydrates	14-26	sucrase-isomaltase	Homo sapiens	56-73
26664010-2	2015	Decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (alpha-amylase and alpha-glucosidase) is one of many approaches used for the management of this disease.	Carbohydrates	89-102	sucrase-isomaltase	Homo sapiens	140-157
26664010-4	2015	MATERIALS AND METHODS: The alpha-amylase and alpha-glucosidase activities were measured in the presence of aqueous and ethanol extracts of the plant parts using starch and p-nitrophenyl-D-glucopyranoside as substrates respectively.	Ethanol	119-126	sucrase-isomaltase	Homo sapiens	45-62
26664010-4	2015	MATERIALS AND METHODS: The alpha-amylase and alpha-glucosidase activities were measured in the presence of aqueous and ethanol extracts of the plant parts using starch and p-nitrophenyl-D-glucopyranoside as substrates respectively.	Starch	161-167	sucrase-isomaltase	Homo sapiens	45-62
26664010-4	2015	MATERIALS AND METHODS: The alpha-amylase and alpha-glucosidase activities were measured in the presence of aqueous and ethanol extracts of the plant parts using starch and p-nitrophenyl-D-glucopyranoside as substrates respectively.	p-nitrophenyl-d-glucopyranoside	172-203	sucrase-isomaltase	Homo sapiens	45-62
26162745-0	2015	Modeling of cooked starch digestion process using recombinant human pancreatic alpha-amylase and maltase-glucoamylase for in vitro evaluation of alpha-glucosidase inhibitors.	Starch	19-25	sucrase-isomaltase	Homo sapiens	145-162
26162745-12	2015	These findings suggest that our in vitro enzymatic system can simulate in vivo starch digestion process, and thus can be used to screen and evaluate alpha-glucosidase inhibitors.	Starch	79-85	sucrase-isomaltase	Homo sapiens	149-166
25845367-3	2015	We demonstrated the robustness, reproducibility and versatility of the method using two molecules that are in clinical trial for Fabry or Pompe disease, Deoxygalactonojirimycin and N-Butyldeoxynojirimycin, and their target enzymes, lysosomal alpha-galactosidaseA and alpha-glucosidase, as test cases.	migalastat	153-176	sucrase-isomaltase	Homo sapiens	267-284
26370656-2	2015	High polyphenolic grape extract (PGE) has been shown to inhibit alpha-amylase and alpha-glucosidase activity, two key enzymes required for starch digestion, in vitro.	phenylglycidyl ether	33-36	sucrase-isomaltase	Homo sapiens	82-99
26370656-2	2015	High polyphenolic grape extract (PGE) has been shown to inhibit alpha-amylase and alpha-glucosidase activity, two key enzymes required for starch digestion, in vitro.	Starch	139-145	sucrase-isomaltase	Homo sapiens	82-99
26207761-0	2015	Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as alpha-Glucosidase and alpha-Amylase Inhibitors.	oleanolic acid saponins	40-63	sucrase-isomaltase	Homo sapiens	67-84
26207761-1	2015	Sixteen naturally occurring oleanolic acid saponins and their derivatives were synthesized in an efficient and practical strategy, and their inhibitory activities against alpha-glucosidase and alpha-amylase were evaluated in vitro.	oleanolic acid saponins	28-51	sucrase-isomaltase	Homo sapiens	171-188
26207761-2	2015	Among all the compounds, 28-O-monoglucoside 8 exhibited remarkably potent inhibitory activity against alpha-glucosidase with an IC50 value of 87.3 microM, which was fivefold stronger than that of the antidiabetic acarbose.	28-o-monoglucoside 8	25-45	sucrase-isomaltase	Homo sapiens	102-119
26207761-2	2015	Among all the compounds, 28-O-monoglucoside 8 exhibited remarkably potent inhibitory activity against alpha-glucosidase with an IC50 value of 87.3 microM, which was fivefold stronger than that of the antidiabetic acarbose.	Acarbose	213-221	sucrase-isomaltase	Homo sapiens	102-119
26207761-3	2015	Based on the preliminary structure-activity relationships, for 28-O-monoglucosides, the presence of a terminal alpha-l-rhamnopyranosyl residue enhanced the alpha-glucosidase and alpha-amylase inhibitory activities.	28-o-monoglucosides	63-82	sucrase-isomaltase	Homo sapiens	156-173
26207761-3	2015	Based on the preliminary structure-activity relationships, for 28-O-monoglucosides, the presence of a terminal alpha-l-rhamnopyranosyl residue enhanced the alpha-glucosidase and alpha-amylase inhibitory activities.	alpha-l-rhamnopyranosyl	111-134	sucrase-isomaltase	Homo sapiens	156-173
26207761-4	2015	Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against alpha-amylase and alpha-glucosidase.	3,28-o-bidesmosides	17-36	sucrase-isomaltase	Homo sapiens	211-228
26207761-4	2015	Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against alpha-amylase and alpha-glucosidase.	Sugars	38-43	sucrase-isomaltase	Homo sapiens	211-228
26207761-4	2015	Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against alpha-amylase and alpha-glucosidase.	Oleanolic Acid	111-125	sucrase-isomaltase	Homo sapiens	211-228
26343100-3	2015	Inhibitors of carbohydrate-hydrolyzing enzymes (such as alpha-glucosidase and alpha-amylase) offer an effective strategy to regulate/prevent hyperglycemia by controlling starch breakdown.	Starch	170-176	sucrase-isomaltase	Homo sapiens	56-73
26183542-0	2015	Synthesis of new oxadiazole derivatives as alpha-glucosidase inhibitors.	Oxadiazoles	17-27	sucrase-isomaltase	Homo sapiens	43-60
26594765-3	2015	All flavonoids and coumarins showed significant alpha-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.	Flavonoids	4-14	sucrase-isomaltase	Homo sapiens	48-65
26594765-3	2015	All flavonoids and coumarins showed significant alpha-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.	Coumarins	19-28	sucrase-isomaltase	Homo sapiens	48-65
26084668-4	2015	We compared the effects of the DPP-4i, sitagliptin, and the alpha-glucosidase inhibitor, voglibose, on LV diastolic function in patients with type 2 diabetes.	voglibose	89-98	sucrase-isomaltase	Homo sapiens	60-77
26154585-1	2015	The alpha-glucosidase inhibitor is a common oral anti-diabetic drug used for controlling carbohydrates normally converted into simple sugars and absorbed by the intestines.	Carbohydrates	89-102	sucrase-isomaltase	Homo sapiens	4-21
26154585-1	2015	The alpha-glucosidase inhibitor is a common oral anti-diabetic drug used for controlling carbohydrates normally converted into simple sugars and absorbed by the intestines.	Sugars	134-140	sucrase-isomaltase	Homo sapiens	4-21
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Curcumin	91-99	sucrase-isomaltase	Homo sapiens	9-26
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	actinodaphine	101-115	sucrase-isomaltase	Homo sapiens	9-26
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	16-h	117-121	sucrase-isomaltase	Homo sapiens	9-26
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Quercetin	123-132	sucrase-isomaltase	Homo sapiens	9-26
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Berberine	134-143	sucrase-isomaltase	Homo sapiens	9-26
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Catechin	149-157	sucrase-isomaltase	Homo sapiens	9-26
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Acarbose	195-203	sucrase-isomaltase	Homo sapiens	9-26
25955493-0	2015	Isatin based Schiff bases as inhibitors of alpha-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies.	Isatin	0-6	sucrase-isomaltase	Homo sapiens	43-60
25959812-0	2015	N-Arylmethylaminoquercitols, a new series of effective antidiabetic agents having alpha-glucosidase inhibition and antioxidant activity.	n-arylmethylaminoquercitols	0-27	sucrase-isomaltase	Homo sapiens	82-99
25959812-2	2015	The targeted N-substituted aminoquercitols having phenolic moiety (7a-7c) displayed significantly enhanced alpha-glucosidase inhibition, which is 26-32 times more potent than that of the unmodified aminoquercitol 6.	n-substituted aminoquercitols	13-42	sucrase-isomaltase	Homo sapiens	107-124
25959812-2	2015	The targeted N-substituted aminoquercitols having phenolic moiety (7a-7c) displayed significantly enhanced alpha-glucosidase inhibition, which is 26-32 times more potent than that of the unmodified aminoquercitol 6.	aminoquercitol	27-41	sucrase-isomaltase	Homo sapiens	107-124
32262403-0	2015	Surface defect rich ZnO quantum dots as antioxidants inhibiting alpha-amylase and alpha-glucosidase: a potential anti-diabetic nanomedicine.	Zinc Oxide	20-23	sucrase-isomaltase	Homo sapiens	82-99
25955493-0	2015	Isatin based Schiff bases as inhibitors of alpha-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies.	Schiff Bases	13-25	sucrase-isomaltase	Homo sapiens	43-60
25955493-1	2015	Isatin base Schiff bases (1-20) were synthesized, characterized by (1)H NMR and EI/MS and evaluated for alpha-glucosidase inhibitory potential.	isatin base	0-11	sucrase-isomaltase	Homo sapiens	104-121
25955493-2	2015	Out of these twenty (20) compounds only six analogs showed potent alpha-glucosidase inhibitory potential with IC50 value ranging in between 2.2+-0.25 and 83.5+-1.0muM when compared with the standard acarbose (IC50=840+-1.73muM).	Acarbose	199-207	sucrase-isomaltase	Homo sapiens	66-83
25816913-0	2015	Dietary phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase with the potential of modulating glucose release.	Glucose	151-158	sucrase-isomaltase	Homo sapiens	99-117
26034806-15	2015	Alpha-glucosidase inhibitors have a weak glucose-lowering effect.	Glucose	41-48	sucrase-isomaltase	Homo sapiens	0-17
25937110-3	2015	In the presence of alpha-glucosidase, aggregation of AuNPs is prohibited due to the oxidation of cysteine to cystine in the system.	Cysteine	97-105	sucrase-isomaltase	Homo sapiens	19-36
25937110-3	2015	In the presence of alpha-glucosidase, aggregation of AuNPs is prohibited due to the oxidation of cysteine to cystine in the system.	Cystine	109-116	sucrase-isomaltase	Homo sapiens	19-36
25978841-13	2015	ADT, especially metformin, alpha-glucosidase inhibitor, and long-acting insulin treatment, may protect patients with DM against these malignancies.	adt	0-3	sucrase-isomaltase	Homo sapiens	27-44
25906471-2	2015	A therapeutic approach is to inhibit intestinal alpha-glucosidase, the key enzyme for dietary carbohydrate digestion, resulting in delayed rate of glucose absorption.	Carbohydrates	94-106	sucrase-isomaltase	Homo sapiens	48-65
25906471-2	2015	A therapeutic approach is to inhibit intestinal alpha-glucosidase, the key enzyme for dietary carbohydrate digestion, resulting in delayed rate of glucose absorption.	Glucose	147-154	sucrase-isomaltase	Homo sapiens	48-65
25906471-13	2015	This is the first report of tea pomace extract significantly inhibits intestinal alpha-glucosidase, resulting in delayed glucose absorption and thereby suppressed postprandial hyperglycemia.	Glucose	121-128	sucrase-isomaltase	Homo sapiens	81-98
25554642-10	2015	The hexane extract also displayed alpha-glucosidase inhibitory activity, with an EC50 of 117.04+-2.34 microg/ml.	Hexanes	4-10	sucrase-isomaltase	Homo sapiens	34-51
25752525-4	2015	Furthermore, one of the thiosemicarbazones was found to be a strong non-competitive inhibitor of alpha-glucosidase (Ki = 9.6 +- 1.6 muM), with an 8-fold increase in activity compared to acarbose (Ki = 77.9 +- 11.4 muM), marketed for the treatment of type-2 diabetes.	Thiosemicarbazones	24-42	sucrase-isomaltase	Homo sapiens	97-114
25752525-4	2015	Furthermore, one of the thiosemicarbazones was found to be a strong non-competitive inhibitor of alpha-glucosidase (Ki = 9.6 +- 1.6 muM), with an 8-fold increase in activity compared to acarbose (Ki = 77.9 +- 11.4 muM), marketed for the treatment of type-2 diabetes.	Acarbose	186-194	sucrase-isomaltase	Homo sapiens	97-114
25759031-0	2015	Design, synthesis and docking study of novel tetracyclic oxindole derivatives as alpha-glucosidase inhibitors.	tetracyclic oxindole	45-65	sucrase-isomaltase	Homo sapiens	81-98
25666467-1	2015	A series of pentahydroxylated pyrrolidines, displaying five contiguous stereogenic centres and epimeric to alpha-glucosidase inhibitor homoDMDP, have been synthesized.	pentahydroxylated pyrrolidines	12-42	sucrase-isomaltase	Homo sapiens	107-124
25666467-1	2015	A series of pentahydroxylated pyrrolidines, displaying five contiguous stereogenic centres and epimeric to alpha-glucosidase inhibitor homoDMDP, have been synthesized.	homodmdp	135-143	sucrase-isomaltase	Homo sapiens	107-124
25620383-6	2015	The ethanol eluents of EUL were first determined to inhibit alpha-glucosidase in vitro, and then the inhibition of the most potent eluent, i.e., 20% ethanol eluent of EUL (EEUL), against carbohydrate-degrading enzymes and glucose transport in Caco-2 cells was demonstrated.	Ethanol	4-11	sucrase-isomaltase	Homo sapiens	60-77
25442631-3	2015	These phenolic compounds not only contributed significantly to the antioxidant activities, but they were also good inhibitors of alpha-glucosidase and lipase, two enzymes, respectively, associated with glucose and lipid digestion in the human intestine, thus contributing significantly to the control of blood glucose levels and obesity.	Glucose	202-209	sucrase-isomaltase	Homo sapiens	129-146
25442631-3	2015	These phenolic compounds not only contributed significantly to the antioxidant activities, but they were also good inhibitors of alpha-glucosidase and lipase, two enzymes, respectively, associated with glucose and lipid digestion in the human intestine, thus contributing significantly to the control of blood glucose levels and obesity.	Glucose	310-317	sucrase-isomaltase	Homo sapiens	129-146
25442631-4	2015	More interestingly, it was the flavonols, not the flavanols, which showed the inhibitory activities against alpha-glucosidase and pancreatic lipase.	Flavonols	31-40	sucrase-isomaltase	Homo sapiens	108-125
25901170-0	2015	Flavonoids from Salvia chloroleuca with alpha-Amylsae and alpha-Glucosidase Inhibitory Effect.	Flavonoids	0-10	sucrase-isomaltase	Homo sapiens	58-75
25901170-1	2015	It is believed that the inhibition of carbohydrate hydrolyzing enzymes including alpha-amylase and alpha-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes.	Carbohydrates	38-50	sucrase-isomaltase	Homo sapiens	99-116
25901170-1	2015	It is believed that the inhibition of carbohydrate hydrolyzing enzymes including alpha-amylase and alpha-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes.	Glucose	183-190	sucrase-isomaltase	Homo sapiens	99-116
25554642-13	2015	The effects of this plant in the treatment of diabetes can be related to the presence of alpha-glucosidase inhibitors, such as the caffeic acid derivative identified in the active extract.	caffeic acid	131-143	sucrase-isomaltase	Homo sapiens	89-106
25585009-0	2015	Synthesis of novel inhibitors of alpha-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies.	benzothiazole	64-77	sucrase-isomaltase	Homo sapiens	33-50
25585009-0	2015	Synthesis of novel inhibitors of alpha-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies.	benzoylhydrazine	98-112	sucrase-isomaltase	Homo sapiens	33-50
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	sucrase-isomaltase	Homo sapiens	162-179
25585009-1	2015	In an effort to design and synthesize a new class of alpha-glucosidase inhibitor, we synthesized benzothiazole hybrid having benzohydrazide moiety (5).	benzothiazole	97-110	sucrase-isomaltase	Homo sapiens	53-70
25585009-1	2015	In an effort to design and synthesize a new class of alpha-glucosidase inhibitor, we synthesized benzothiazole hybrid having benzohydrazide moiety (5).	benzoylhydrazine	125-139	sucrase-isomaltase	Homo sapiens	53-70
24825096-3	2015	Thus, this study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid with alpha-amylase and alpha-glucosidase (key enzymes linked to type 2 diabetes) activities in vitro.	caffeic acid	70-82	sucrase-isomaltase	Homo sapiens	127-144
24825096-9	2015	CONCLUSIONS: The esterification of caffeic acid with quinic acid, producing chlorogenic acid, reduces their ability to inhibit alpha-amylase and alpha-glucosidase activities.	caffeic acid	35-47	sucrase-isomaltase	Homo sapiens	145-162
24825096-3	2015	Thus, this study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid with alpha-amylase and alpha-glucosidase (key enzymes linked to type 2 diabetes) activities in vitro.	Chlorogenic Acid	87-103	sucrase-isomaltase	Homo sapiens	127-144
24825096-9	2015	CONCLUSIONS: The esterification of caffeic acid with quinic acid, producing chlorogenic acid, reduces their ability to inhibit alpha-amylase and alpha-glucosidase activities.	Quinic Acid	53-64	sucrase-isomaltase	Homo sapiens	145-162
24825096-4	2015	METHODS: The inhibitory effect of the phenolic acids on alpha-amylase and alpha-glucosidase activities was evaluated.	phenolic acid	38-52	sucrase-isomaltase	Homo sapiens	74-91
24825096-9	2015	CONCLUSIONS: The esterification of caffeic acid with quinic acid, producing chlorogenic acid, reduces their ability to inhibit alpha-amylase and alpha-glucosidase activities.	Chlorogenic Acid	76-92	sucrase-isomaltase	Homo sapiens	145-162
24825096-6	2015	RESULTS: The results revealed that both phenolic acids inhibited alpha-amylase and alpha-glucosidase activities in a dose-dependent manner (2-8 mug/mL).	phenolic acid	40-54	sucrase-isomaltase	Homo sapiens	83-100
24825096-10	2015	Thus, the inhibition of alpha-amylase and alpha-glucosidase activities by the phenolic acids could be part of the possible mechanism by which the phenolic acids exert their antidiabetic effects.	phenolic acid	78-92	sucrase-isomaltase	Homo sapiens	42-59
24825096-7	2015	However, caffeic acid had a significantly (p&lt;0.05) higher inhibitory effect on alpha-amylase [IC50 (concentration of sample causing 50% enzyme inhibition)=3.68 mug/mL] and alpha-glucosidase (IC50=4.98 mug/mL) activities than chlorogenic acid (alpha-amylase IC50=9.10 mug/mL and alpha-glucosidase IC50=9.24 mug/mL).	caffeic acid	9-21	sucrase-isomaltase	Homo sapiens	175-192
24825096-10	2015	Thus, the inhibition of alpha-amylase and alpha-glucosidase activities by the phenolic acids could be part of the possible mechanism by which the phenolic acids exert their antidiabetic effects.	phenolic acid	146-160	sucrase-isomaltase	Homo sapiens	42-59
24825096-7	2015	However, caffeic acid had a significantly (p&lt;0.05) higher inhibitory effect on alpha-amylase [IC50 (concentration of sample causing 50% enzyme inhibition)=3.68 mug/mL] and alpha-glucosidase (IC50=4.98 mug/mL) activities than chlorogenic acid (alpha-amylase IC50=9.10 mug/mL and alpha-glucosidase IC50=9.24 mug/mL).	caffeic acid	9-21	sucrase-isomaltase	Homo sapiens	281-298
25730784-0	2015	Comparative anti-glycation and alpha-glucosidase inhibition studies of microbial transformed compounds of dydrogesterone.	Dydrogesterone	106-120	sucrase-isomaltase	Homo sapiens	31-48
25812367-5	2015	Also combination therapy with glinides and alpha-glucosidase inhibitors shows a good profile of daily blood glucose level in these patients.	Glucose	108-115	sucrase-isomaltase	Homo sapiens	43-60
25523370-0	2015	Inhibitory effect of black tea and its combination with acarbose on small intestinal alpha-glucosidase activity.	Acarbose	56-64	sucrase-isomaltase	Homo sapiens	85-102
27419082-8	2016	The results showed that ADJ6 had a significant inhibitory activity on alpha-amylase and alpha-glucosidase; however, its inhibitory activity was less than that of acarbose.	adj6	24-28	sucrase-isomaltase	Homo sapiens	88-105
25679337-1	2015	The crude methanol extract of Pueraria lobata was investigated by dual high-resolution alpha-glucosidase inhibition and radical scavenging profiling combined with hyphenated HPLC-HRMS-SPE-NMR.	Methanol	10-18	sucrase-isomaltase	Homo sapiens	87-104
25523370-7	2015	Kinetic studies of rat small intestinal alpha-glucosidase activity revealed that the combination of JAT and the alpha-glucosidase inhibitor, acarbose, showed a mixed-type inhibition.	Acarbose	141-149	sucrase-isomaltase	Homo sapiens	40-57
25523370-7	2015	Kinetic studies of rat small intestinal alpha-glucosidase activity revealed that the combination of JAT and the alpha-glucosidase inhibitor, acarbose, showed a mixed-type inhibition.	Acarbose	141-149	sucrase-isomaltase	Homo sapiens	112-129
25523370-12	2015	CONCLUSIONS: JAT was demonstrated to inhibit the degradation of disaccharides into monosaccharides by alpha-glucosidase in the small intestine.	Disaccharides	64-77	sucrase-isomaltase	Homo sapiens	102-119
25523370-12	2015	CONCLUSIONS: JAT was demonstrated to inhibit the degradation of disaccharides into monosaccharides by alpha-glucosidase in the small intestine.	Monosaccharides	83-98	sucrase-isomaltase	Homo sapiens	102-119
25474715-3	2015	The developed method showed high selectivity and specificity to directly screen alpha-glucosidase ligands from complex system by testing mixtures of positive ((+)-catechin) and negative (salicylic acid) controls in the optimized conditions.	Catechin	159-171	sucrase-isomaltase	Homo sapiens	80-97
25516912-6	2015	With the enzymatic hydrolysis of alpha-glucosidase, maltotriose and maltose can be turned into glucose rapidly, which can be quantitatively measured using a portable PGM.	Glucose	95-102	sucrase-isomaltase	Homo sapiens	33-50
25528720-0	2015	Triazinoindole analogs as potent inhibitors of alpha-glucosidase: synthesis, biological evaluation and molecular docking studies.	Triazinoindole	0-14	sucrase-isomaltase	Homo sapiens	47-64
25528720-2	2015	All eleven (11) analogs showed different range of alpha-glucosidase inhibitory potential with IC50 value ranging between 2.46+-0.008 and 312.79+-0.06 muM when compared with the standard acarbose (IC50, 38.25+-0.12 muM).	Acarbose	186-194	sucrase-isomaltase	Homo sapiens	50-67
25044702-2	2015	METHODS: Data from ten post-marketing non-interventional studies using acarbose, the most widely used alpha-glucosidase inhibitor, from 21 countries, provinces and country groups were pooled.	Acarbose	71-79	sucrase-isomaltase	Homo sapiens	102-119
25516912-6	2015	With the enzymatic hydrolysis of alpha-glucosidase, maltotriose and maltose can be turned into glucose rapidly, which can be quantitatively measured using a portable PGM.	maltotriose	52-63	sucrase-isomaltase	Homo sapiens	33-50
25516912-6	2015	With the enzymatic hydrolysis of alpha-glucosidase, maltotriose and maltose can be turned into glucose rapidly, which can be quantitatively measured using a portable PGM.	Maltose	68-75	sucrase-isomaltase	Homo sapiens	33-50
25475890-0	2015	Effects of L-malic acid on alpha-glucosidase: inhibition kinetics and computational molecular dynamics simulations.	L-Malic acid	11-23	sucrase-isomaltase	Homo sapiens	27-44
25475890-1	2015	The inhibitory effect of L-malic acid (MA) on alpha-glucosidase (EC 3.2.1.20) was investigated by combination study between inhibition kinetics and computational simulations.	L-Malic acid	25-37	sucrase-isomaltase	Homo sapiens	46-63
25475890-3	2015	The tertiary conformation study with an application of spectrofluorimetry showed that MA modulated the tertiary structural conformation of alpha-glucosidase both on the overall and on regional active site pocket, which monitored by red-shift intrinsic fluorescence peak with decreases intensities, and the significant intensity increasing of 1-anilinonaphthalene-8-sulfonate (ANS)-binding fluorescence, respectively.	1-anilinonaphthalene-8-sulfonate	342-374	sucrase-isomaltase	Homo sapiens	139-156
25475890-3	2015	The tertiary conformation study with an application of spectrofluorimetry showed that MA modulated the tertiary structural conformation of alpha-glucosidase both on the overall and on regional active site pocket, which monitored by red-shift intrinsic fluorescence peak with decreases intensities, and the significant intensity increasing of 1-anilinonaphthalene-8-sulfonate (ANS)-binding fluorescence, respectively.	1-anilino-8-naphthalenesulfonate	376-379	sucrase-isomaltase	Homo sapiens	139-156
25462626-0	2015	Organocatalyzed solvent free an efficient novel synthesis of 2,4,5-trisubstituted imidazoles for alpha-glucosidase inhibition to treat diabetes.	2,4,5-trisubstituted imidazoles	61-92	sucrase-isomaltase	Homo sapiens	97-114
25462626-3	2015	Evaluation of alpha-glucosidase inhibitory activity of these imidazole derivatives revealed that most of them presented good alpha-glucosidase inhibition at low micro-molar concentrations.	imidazole	61-70	sucrase-isomaltase	Homo sapiens	14-31
25462626-3	2015	Evaluation of alpha-glucosidase inhibitory activity of these imidazole derivatives revealed that most of them presented good alpha-glucosidase inhibition at low micro-molar concentrations.	imidazole	61-70	sucrase-isomaltase	Homo sapiens	125-142
25474715-3	2015	The developed method showed high selectivity and specificity to directly screen alpha-glucosidase ligands from complex system by testing mixtures of positive ((+)-catechin) and negative (salicylic acid) controls in the optimized conditions.	Salicylic Acid	187-201	sucrase-isomaltase	Homo sapiens	80-97
25474715-4	2015	As a result, thirteen prototype isoflavonoids and one monohydroxylated metabolic isoflavonoid with alpha-glucosidase binding activity were observed.	isoflavonoids	32-45	sucrase-isomaltase	Homo sapiens	99-116
25474715-4	2015	As a result, thirteen prototype isoflavonoids and one monohydroxylated metabolic isoflavonoid with alpha-glucosidase binding activity were observed.	isoflavonoid	32-44	sucrase-isomaltase	Homo sapiens	99-116
25474715-6	2015	Particularly, except for calycosin and formononetin, the other twelve isoflavonoids were found as new alpha-glucosidase ligands.	isoflavonoids	70-83	sucrase-isomaltase	Homo sapiens	102-119
25685364-1	2015	The alpha-glucosidase inhibitor acarbose, which slows carbohydrate digestion and blunts postprandial rises in plasma glucose, has long been used to treat patients with type 2 diabetes or glucose intolerance.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
25920275-0	2015	Arylalkanones from Horsfieldia macrobotrys are effective antidiabetic agents achieved by alpha-glucosidase inhibition and radical scavenging.	arylalkanones	0-13	sucrase-isomaltase	Homo sapiens	89-106
25920275-7	2015	Arylalkanone 1 inhibited yeast alpha-glucosidase in a mixed-type manner in which the noncompetitive pathway was dominant over competitive inhibition.	arylalkanone	0-12	sucrase-isomaltase	Homo sapiens	31-48
25920275-8	2015	This study is the first report of alpha-glucosidase inhibition of arylalkenone-type compounds and the first phytochemicals from H. macrobotrys.	arylalkenone	66-78	sucrase-isomaltase	Homo sapiens	34-51
25502825-1	2015	The potent alpha-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a beta-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY).	beta-carboline alkaloid	139-162	sucrase-isomaltase	Homo sapiens	11-28
25502825-1	2015	The potent alpha-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a beta-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY).	norharman	163-172	sucrase-isomaltase	Homo sapiens	11-28
25502825-1	2015	The potent alpha-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a beta-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY).	9H-pyrido(3.4-b)indole	174-197	sucrase-isomaltase	Homo sapiens	11-28
25502825-1	2015	The potent alpha-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a beta-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY).	Carbon	287-288	sucrase-isomaltase	Homo sapiens	11-28
25502825-2	2015	The norharman showed a potent inhibition against alpha-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively.	norharman	4-13	sucrase-isomaltase	Homo sapiens	49-66
25502825-3	2015	A Lineweaver-Burk plot revealed that norharman inhibited alpha-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM.	norharman	37-46	sucrase-isomaltase	Homo sapiens	57-74
25685364-1	2015	The alpha-glucosidase inhibitor acarbose, which slows carbohydrate digestion and blunts postprandial rises in plasma glucose, has long been used to treat patients with type 2 diabetes or glucose intolerance.	Carbohydrates	54-66	sucrase-isomaltase	Homo sapiens	4-21
25685364-1	2015	The alpha-glucosidase inhibitor acarbose, which slows carbohydrate digestion and blunts postprandial rises in plasma glucose, has long been used to treat patients with type 2 diabetes or glucose intolerance.	Glucose	117-124	sucrase-isomaltase	Homo sapiens	4-21
25685364-1	2015	The alpha-glucosidase inhibitor acarbose, which slows carbohydrate digestion and blunts postprandial rises in plasma glucose, has long been used to treat patients with type 2 diabetes or glucose intolerance.	Glucose	187-194	sucrase-isomaltase	Homo sapiens	4-21
25380641-1	2015	The present study was aimed to investigate in vitro alpha-glucosidase inhibition, antioxidant, anticancer, and antimycobacterial activities of the ethyl acetate extract of A. tamilnadensis leaves.	ethyl acetate	147-160	sucrase-isomaltase	Homo sapiens	52-69
26656820-0	2015	Microplate Assay of alpha-Glucosidase and Its Inhibitors Based on the Direct Reduction of Molybdosilicate by Glucose.	molybdosilicate	90-105	sucrase-isomaltase	Homo sapiens	20-37
26656820-0	2015	Microplate Assay of alpha-Glucosidase and Its Inhibitors Based on the Direct Reduction of Molybdosilicate by Glucose.	Glucose	109-116	sucrase-isomaltase	Homo sapiens	20-37
26656820-2	2015	Sci., 2013, 29, 1021) was optimized for the high-throughput screening of alpha-glucosidase, which hydrolyzes an alpha-1,4-glycosidic bond of starch and related oligo- and polysaccharides, followed by the release of D-glucose from the non-reducing ends.	Starch	141-147	sucrase-isomaltase	Homo sapiens	73-90
26656820-2	2015	Sci., 2013, 29, 1021) was optimized for the high-throughput screening of alpha-glucosidase, which hydrolyzes an alpha-1,4-glycosidic bond of starch and related oligo- and polysaccharides, followed by the release of D-glucose from the non-reducing ends.	oligo- and polysaccharides	160-186	sucrase-isomaltase	Homo sapiens	73-90
26656820-2	2015	Sci., 2013, 29, 1021) was optimized for the high-throughput screening of alpha-glucosidase, which hydrolyzes an alpha-1,4-glycosidic bond of starch and related oligo- and polysaccharides, followed by the release of D-glucose from the non-reducing ends.	Glucose	215-224	sucrase-isomaltase	Homo sapiens	73-90
26656820-7	2015	Since maltose cannot render the mixture blue as strongly as glucose, the present method has been successfully applied to a microtiter plate assay of alpha-glucosidase with the disaccharide.	Maltose	6-13	sucrase-isomaltase	Homo sapiens	149-166
26656820-7	2015	Since maltose cannot render the mixture blue as strongly as glucose, the present method has been successfully applied to a microtiter plate assay of alpha-glucosidase with the disaccharide.	Glucose	60-67	sucrase-isomaltase	Homo sapiens	149-166
26656820-7	2015	Since maltose cannot render the mixture blue as strongly as glucose, the present method has been successfully applied to a microtiter plate assay of alpha-glucosidase with the disaccharide.	Disaccharides	176-188	sucrase-isomaltase	Homo sapiens	149-166
25380641-8	2015	The current study suggests that the ethyl acetate extract of A. tamilnadensis is a potential source of natural alpha-glucosidase inhibitor and antioxidant for protection as well as prevention of life-threatening diseases like cancer.	ethyl acetate	36-49	sucrase-isomaltase	Homo sapiens	111-128
25452780-2	2015	The aim of the present study was to examine the postprandial effects of the dipeptidyl peptidase-4 inhibitor vildagliptin and the alpha-glucosidase inhibitor voglibose on endothelial dysfunction and lipid profiles following a single administration.	voglibose	158-167	sucrase-isomaltase	Homo sapiens	130-147
26350092-3	2015	METHODS: Activity of alpha-glucosidase was measured using 4-methylumbelliferyl-alpha-D-glucopyranoside with the presence of acarbose, inhibitor that eliminates isoenzyme interference of maltase-glucoamylase.	4-methylumbelliferyl glucoside	58-102	sucrase-isomaltase	Homo sapiens	21-38
26350092-3	2015	METHODS: Activity of alpha-glucosidase was measured using 4-methylumbelliferyl-alpha-D-glucopyranoside with the presence of acarbose, inhibitor that eliminates isoenzyme interference of maltase-glucoamylase.	Acarbose	124-132	sucrase-isomaltase	Homo sapiens	21-38
25948326-1	2015	A series of piperic acid amides (4-24, 29, 30) were synthesized and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and alpha-glucosidase inhibitory activities were evaluated.	piperic acid amides	12-31	sucrase-isomaltase	Homo sapiens	139-156
25948326-3	2015	The amides 10, 18 and 23 showed higher inhibitory activity of alpha-glucosidase (10: IC50 21 microM; 18: IC50 21 microM; 23: IC50 12 microM).	Amides	4-10	sucrase-isomaltase	Homo sapiens	62-79
25948326-4	2015	These data suggest that the hydrophobicity of the conjugated amines is an important determinant of alpha-glucosidase inhibitory activity.	Amines	61-67	sucrase-isomaltase	Homo sapiens	99-116
25948326-5	2015	In addition, the amides 13 and 15 showed both potent DPPH free radical scavenging activity and alpha-glucosidase inhibitory activity (13: IC50 46 microM; 15: IC50 46 microM).	Amides	17-23	sucrase-isomaltase	Homo sapiens	95-112
25948326-6	2015	This is the first report identifying the DPPH free radical scavenging and alpha-glucosidase inhibitory activities of piperic acid amides and suggests that these amides may serve as lead compounds for the development of novel alpha-glucosidase inhibitors with antioxidant activity.	1,1-diphenyl-2-picrylhydrazyl	41-45	sucrase-isomaltase	Homo sapiens	225-242
25948326-6	2015	This is the first report identifying the DPPH free radical scavenging and alpha-glucosidase inhibitory activities of piperic acid amides and suggests that these amides may serve as lead compounds for the development of novel alpha-glucosidase inhibitors with antioxidant activity.	piperic acid amides	117-136	sucrase-isomaltase	Homo sapiens	74-91
25881823-0	2015	Silver(I) complexes of 2,4-dihydroxybenzaldehyde-amino acid Schiff bases-Novel noncompetitive alpha-glucosidase inhibitors.	2,4-dihydroxybenzaldehyde-	23-49	sucrase-isomaltase	Homo sapiens	94-111
25881823-0	2015	Silver(I) complexes of 2,4-dihydroxybenzaldehyde-amino acid Schiff bases-Novel noncompetitive alpha-glucosidase inhibitors.	amino acid schiff bases	49-72	sucrase-isomaltase	Homo sapiens	94-111
25881823-1	2015	A series of silver(I) complexes of 2,4-dihydroxybenzaldehyde-amino acid Schiff bases were designed and tested for alpha-glucosidase inhibition.	2,4-dihydroxybenzaldehyde-amino acid schiff bases	35-84	sucrase-isomaltase	Homo sapiens	114-131
25881823-5	2015	Our results reveal that Schiff base silver complexes may be explored for their therapeutic potential as alternatives of alpha-glucosidase inhibitors.	Schiff Bases	24-35	sucrase-isomaltase	Homo sapiens	120-137
25948326-6	2015	This is the first report identifying the DPPH free radical scavenging and alpha-glucosidase inhibitory activities of piperic acid amides and suggests that these amides may serve as lead compounds for the development of novel alpha-glucosidase inhibitors with antioxidant activity.	piperic acid amides	117-136	sucrase-isomaltase	Homo sapiens	225-242
25948326-6	2015	This is the first report identifying the DPPH free radical scavenging and alpha-glucosidase inhibitory activities of piperic acid amides and suggests that these amides may serve as lead compounds for the development of novel alpha-glucosidase inhibitors with antioxidant activity.	Amides	130-136	sucrase-isomaltase	Homo sapiens	74-91
25948326-6	2015	This is the first report identifying the DPPH free radical scavenging and alpha-glucosidase inhibitory activities of piperic acid amides and suggests that these amides may serve as lead compounds for the development of novel alpha-glucosidase inhibitors with antioxidant activity.	Amides	130-136	sucrase-isomaltase	Homo sapiens	225-242
26235001-0	2015	The alpha-Glucosidase and alpha-Amylase Enzyme Inhibitory of Hydroxytyrosol and Oleuropein.	3,4-dihydroxyphenylethanol	61-75	sucrase-isomaltase	Homo sapiens	4-21
25841374-3	2015	One antidiabetic therapeutic approach is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate-digesting enzymes such as alpha-amylase and alpha-glucosidase.	Carbohydrates	128-140	sucrase-isomaltase	Homo sapiens	185-202
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	29-42	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	44-49	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	Butanols	74-80	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	98-111	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	113-118	sucrase-isomaltase	Homo sapiens	140-157
26179526-2	2015	We herein report the case of a 73-year old man who received treatment with an alpha glucosidase inhibitor (acarbose) and presented with acute abdomen.	Acarbose	107-115	sucrase-isomaltase	Homo sapiens	78-95
26235001-2	2015	The objective of this research was to evaluate the inhibitory effect of the hydroxytyrosol and the oleuropein against alpha-amylase and alpha-glucosidase.	3,4-dihydroxyphenylethanol	76-90	sucrase-isomaltase	Homo sapiens	136-153
26235001-4	2015	The result shows that the hydroxytyrosol had the strongest alpha-glucosidase inhibitory effect with IC50 values of 150 muM with mild inhibition against alpha-amylase.	3,4-dihydroxyphenylethanol	26-40	sucrase-isomaltase	Homo sapiens	59-76
26235001-9	2015	These results suggest that the hydroxytyrosol and oleuropein are two potential effective alpha-glucosidase inhibitors for management of postprandial hyperglycemia.	3,4-dihydroxyphenylethanol	31-45	sucrase-isomaltase	Homo sapiens	89-106
26205959-0	2015	alpha-Glucosidase activity of oleanolic acid and its oxidative metabolites: DFT and Docking studies.	Oleanolic Acid	30-44	sucrase-isomaltase	Homo sapiens	0-17
26205959-1	2015	A natural pentacyclic triterpenoid oleanolic acid 1 and its biotransformed metabolites 2-3 are potential alpha-glucosidase inhibitors.	pentacyclic	10-21	sucrase-isomaltase	Homo sapiens	105-122
26205959-1	2015	A natural pentacyclic triterpenoid oleanolic acid 1 and its biotransformed metabolites 2-3 are potential alpha-glucosidase inhibitors.	triterpenoid TP-222	22-34	sucrase-isomaltase	Homo sapiens	105-122
26205959-1	2015	A natural pentacyclic triterpenoid oleanolic acid 1 and its biotransformed metabolites 2-3 are potential alpha-glucosidase inhibitors.	Oleanolic Acid	35-49	sucrase-isomaltase	Homo sapiens	105-122
26080540-3	2015	In recent year, a number of investigators reported medicinal fungal polysaccharides showed good anti-diabetes and hypoglycemic activity, and their acting mechanisms involved in glycometabolism and beta cell function, e. g. promoting glycogen synthesis, promoting glycolysis, inhibiting the activity of alpha-glucosidase, promoting insulin secretion, increasing insulin sensitivity, enhancing antioxidation.	Polysaccharides	68-83	sucrase-isomaltase	Homo sapiens	302-319
25853956-8	2015	RESULTS: The extract results endowed with alpha-glucosidase inhibitory activity (IC50 32 microg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known alpha-glucosidase inhibitor (acarbose and miglitol).	Acarbose	258-266	sucrase-isomaltase	Homo sapiens	42-59
25853956-8	2015	RESULTS: The extract results endowed with alpha-glucosidase inhibitory activity (IC50 32 microg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known alpha-glucosidase inhibitor (acarbose and miglitol).	Acarbose	258-266	sucrase-isomaltase	Homo sapiens	229-246
25853956-8	2015	RESULTS: The extract results endowed with alpha-glucosidase inhibitory activity (IC50 32 microg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known alpha-glucosidase inhibitor (acarbose and miglitol).	miglitol	271-279	sucrase-isomaltase	Homo sapiens	42-59
25853956-8	2015	RESULTS: The extract results endowed with alpha-glucosidase inhibitory activity (IC50 32 microg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known alpha-glucosidase inhibitor (acarbose and miglitol).	miglitol	271-279	sucrase-isomaltase	Homo sapiens	229-246
26989482-0	2015	Structure Activity Related, Mechanistic, and Modeling Studies of Gallotannins containing a Glucitol-Core and alpha-Glucosidase.	Hydrolyzable Tannins	65-77	sucrase-isomaltase	Homo sapiens	109-126
26989482-1	2015	Gallotannins containing a glucitol core, which are only produced by members of the maple (Acer) genus, are more potent alpha-glucosidase inhibitors than the clinical drug, acarbose.	Hydrolyzable Tannins	0-12	sucrase-isomaltase	Homo sapiens	119-136
26989482-1	2015	Gallotannins containing a glucitol core, which are only produced by members of the maple (Acer) genus, are more potent alpha-glucosidase inhibitors than the clinical drug, acarbose.	Sorbitol	26-34	sucrase-isomaltase	Homo sapiens	119-136
26989482-3	2015	Herein, we investigated ligand-enzyme interactions and binding mechanisms of a series of "glucitol-core containing gallotannins (GCGs)" against the alpha-glucosidase enzyme.	Sorbitol	90-98	sucrase-isomaltase	Homo sapiens	148-165
26989482-3	2015	Herein, we investigated ligand-enzyme interactions and binding mechanisms of a series of "glucitol-core containing gallotannins (GCGs)" against the alpha-glucosidase enzyme.	Hydrolyzable Tannins	115-127	sucrase-isomaltase	Homo sapiens	148-165
26989482-3	2015	Herein, we investigated ligand-enzyme interactions and binding mechanisms of a series of "glucitol-core containing gallotannins (GCGs)" against the alpha-glucosidase enzyme.	gcgs	129-133	sucrase-isomaltase	Homo sapiens	148-165
26989482-5	2015	All of the GCGs were noncompetitive inhibitors of alpha-glucosidase and their interactions with the enzyme were further explored using biophysical and spectroscopic measurements.	gcgs	11-15	sucrase-isomaltase	Homo sapiens	50-67
26989482-6	2015	Thermodynamic parameters (by isothermal titration calorimetry) revealed a 1:1 binding ratio between GCGs and alpha-glucosidase.	gcgs	100-104	sucrase-isomaltase	Homo sapiens	109-126
26989482-7	2015	The binding regions between the GCGs and alpha-glucosidase, probed by a fluorescent tag, 1,1"-bis(4-anilino-5-napththalenesulfonic acid, revealed that the GCGs decreased the hydrophobic surface of the enzyme.	gcgs	32-36	sucrase-isomaltase	Homo sapiens	41-58
26989482-7	2015	The binding regions between the GCGs and alpha-glucosidase, probed by a fluorescent tag, 1,1"-bis(4-anilino-5-napththalenesulfonic acid, revealed that the GCGs decreased the hydrophobic surface of the enzyme.	1,1"-bis(4-anilino-5-napththalenesulfonic acid	89-135	sucrase-isomaltase	Homo sapiens	41-58
26989482-7	2015	The binding regions between the GCGs and alpha-glucosidase, probed by a fluorescent tag, 1,1"-bis(4-anilino-5-napththalenesulfonic acid, revealed that the GCGs decreased the hydrophobic surface of the enzyme.	gcgs	155-159	sucrase-isomaltase	Homo sapiens	41-58
26989482-8	2015	In addition, circular dichroism analyses showed that the GCGs bind to alpha-glucosidase and lead to loss of the secondary alpha-helix structure of the protein.	gcgs	57-61	sucrase-isomaltase	Homo sapiens	70-87
26989482-9	2015	Also, molecular modeling was used to predict the binding site between the GCGs and the alpha-glucosidase enzyme.	gcgs	74-78	sucrase-isomaltase	Homo sapiens	87-104
26989482-10	2015	This is the first study to evaluate the mechanisms of inhibitory activities of gallotannins containing a glucitol core on alpha-glucosidase.	Hydrolyzable Tannins	79-91	sucrase-isomaltase	Homo sapiens	122-139
26989482-10	2015	This is the first study to evaluate the mechanisms of inhibitory activities of gallotannins containing a glucitol core on alpha-glucosidase.	Sorbitol	105-113	sucrase-isomaltase	Homo sapiens	122-139
25393608-2	2014	alpha-Glucosidase activity in the UPS was completely inactivated by two-stage MB-CO2 with a heating coil at 45  C for 50 min, 55  C for 5 min, 65  C for 10 s (MB65), and 75  C for 1 s, respectively.	Carbon Dioxide	81-84	sucrase-isomaltase	Homo sapiens	0-17
25419864-0	2014	Benzophenone C- and O-glucosides from Cyclopia genistoides (Honeybush) inhibit mammalian alpha-glucosidase.	benzophenone c- and o-glucosides	0-32	sucrase-isomaltase	Homo sapiens	89-106
25419864-3	2014	The isolated compounds showed alpha-glucosidase inhibitory activity against an enzyme mixture extracted from rat intestinal acetone powder.	Acetone	124-131	sucrase-isomaltase	Homo sapiens	30-47
25305717-1	2014	A new series of 1,9-acetals of forskolin were synthesized by treating with aromatic and aliphatic aldehydes using Ceric ammonium nitrate as catalyst and evaluated for anticancer and alpha-glucosidase inhibition activities.	Colforsin	31-40	sucrase-isomaltase	Homo sapiens	182-199
25451999-0	2014	Amine-linked diquercitols as new alpha-glucosidase inhibitors.	amine-linked diquercitols	0-25	sucrase-isomaltase	Homo sapiens	33-50
25305717-5	2014	In silico based docking, ADME and toxicity risk assessment studies also showed discernible alpha-glucosidase activity for compounds 1g, 1p compared to standard acarbose.	Acarbose	160-168	sucrase-isomaltase	Homo sapiens	91-108
24863482-4	2014	Our data show that a major long term effect of Miglustat is its interference with N-glycosylation of the proteins in the ER leading to a delay in the trafficking of sucrase-isomaltase.	Nitrogen	82-83	sucrase-isomaltase	Homo sapiens	165-183
24837940-5	2014	Unsupervised principal component analysis of samples from 2012 indicated that a major difference between fresh material and dried material is the increased amount of quercetin, a known alpha-glucosidase inhibitor.	Quercetin	166-175	sucrase-isomaltase	Homo sapiens	185-202
25052852-5	2014	alpha-Glucosidase activity was analyzed by tandem-mass spectrometry in dried blood spots from patients treated with enzyme replacement therapy, either alone or in combination with the chaperone N-butyldeoxynojirimycin given at the time of the enzyme infusion.	miglustat	194-217	sucrase-isomaltase	Homo sapiens	0-17
24816820-0	2014	Evaluation of Salacia species as anti-diabetic natural resources based on quantitative analysis of eight sulphonium constituents: a new class of alpha-glucosidase inhibitors.	Sulfonium	105-115	sucrase-isomaltase	Homo sapiens	145-162
25079671-0	2014	Switching alpha-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients.	Glucose	59-66	sucrase-isomaltase	Homo sapiens	10-27
25037326-3	2014	In the present study, six starches and one glycogen were pre-hydrolyzed by alpha-amylase for various time periods, and then further hydrolyzed with the mucosal alpha-glucosidase, the N-terminal subunit of maltase-glucoamylase (Nt-MGAM), to generate free glucose.	Starch	26-34	sucrase-isomaltase	Homo sapiens	160-177
25037326-3	2014	In the present study, six starches and one glycogen were pre-hydrolyzed by alpha-amylase for various time periods, and then further hydrolyzed with the mucosal alpha-glucosidase, the N-terminal subunit of maltase-glucoamylase (Nt-MGAM), to generate free glucose.	Glucose	254-261	sucrase-isomaltase	Homo sapiens	160-177
25037326-9	2014	It further supported the hypothesis that the internal structure of starch affects its digestibility at the mucosal alpha-glucosidase level.	Starch	67-73	sucrase-isomaltase	Homo sapiens	115-132
25151088-0	2014	Oxadiazoles and thiadiazoles: novel alpha-glucosidase inhibitors.	Oxadiazoles	0-11	sucrase-isomaltase	Homo sapiens	36-53
25151088-0	2014	Oxadiazoles and thiadiazoles: novel alpha-glucosidase inhibitors.	Thiadiazoles	16-28	sucrase-isomaltase	Homo sapiens	36-53
25151088-1	2014	Oxadiazoles and thiadiazoles 1-37 were synthesized and evaluated for the first time for their alpha-glucosidase inhibitory activities.	Oxadiazoles	0-11	sucrase-isomaltase	Homo sapiens	94-111
25151088-1	2014	Oxadiazoles and thiadiazoles 1-37 were synthesized and evaluated for the first time for their alpha-glucosidase inhibitory activities.	thiadiazoles 1-37	16-33	sucrase-isomaltase	Homo sapiens	94-111
24858195-9	2014	The Schiff base metal complexes emerges effective alpha-glucosidase inhibitory activity than free Schiff base ligand.	Schiff Bases	4-15	sucrase-isomaltase	Homo sapiens	50-67
24858195-9	2014	The Schiff base metal complexes emerges effective alpha-glucosidase inhibitory activity than free Schiff base ligand.	Metals	16-21	sucrase-isomaltase	Homo sapiens	50-67
24858195-9	2014	The Schiff base metal complexes emerges effective alpha-glucosidase inhibitory activity than free Schiff base ligand.	Schiff Bases	98-109	sucrase-isomaltase	Homo sapiens	50-67
30011737-4	2014	A significant decrease in polyphenols was observed for the sample collected from dialysis phase, with only 11% of non-digested original polyphenols permeating through the dialysis membrane (0.63mg) and preserving an inhibitory effect against alpha-glucosidase to some extent.	Polyphenols	26-37	sucrase-isomaltase	Homo sapiens	242-259
24877997-2	2014	We tested the alpha-glucosidase inhibitor celgosivir as a treatment for acute dengue fever.	celgosivir	42-52	sucrase-isomaltase	Homo sapiens	14-31
24973028-0	2014	Synthesis and biological evaluation of alpha-1-C-4"-arylbutyl-L-arabinoiminofuranoses, a new class of alpha-glucosidase inhibitors.	alpha-1-c-4"-arylbutyl-l-arabinoiminofuranoses	39-85	sucrase-isomaltase	Homo sapiens	102-119
24963542-3	2014	A carbohydrate-rich diet can cause more load on the intestinal cells producing alpha-glucosidase.	Carbohydrates	2-14	sucrase-isomaltase	Homo sapiens	79-96
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Catechin	119-127	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Chitosan	129-138	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Catechin	142-150	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Acarbose	154-162	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Acarbose	242-250	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	catechin-g-chitosan	119-138	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Catechin	142-150	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Chitosan	130-138	sucrase-isomaltase	Homo sapiens	57-74
25061309-1	2014	Acarbose is an alpha-glucosidase inhibitor that is commonly used to control postprandial blood glucose.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	15-32
25077287-6	2014	Alpha glucosidase inhibitors and plasmapheresis were more potent in limiting glucose excursions than corticosteroid or diet-only treatments.	Glucose	77-84	sucrase-isomaltase	Homo sapiens	0-17
24887259-7	2014	The polyanion [P6W18O79](20-) was found to be the most potent inhibitor of alpha-glucosidase (IC50 = 1.33 +- 0.41 muM), ALR1 (IC50 = 0.4 +- 0.009 muM) and ALR2 (IC50 = 0.38 +- 0.02 muM).	polyanion [p6w18o79	4-23	sucrase-isomaltase	Homo sapiens	75-92
24952856-3	2014	Acarbose, an alpha-glucosidase inhibitor that lowers postprandial blood glucose, has been shown to reduce T2DM risk by 25%, and possibly cardiovascular risk in impaired glucose tolerance subjects without cardiovascular disease.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
24952856-3	2014	Acarbose, an alpha-glucosidase inhibitor that lowers postprandial blood glucose, has been shown to reduce T2DM risk by 25%, and possibly cardiovascular risk in impaired glucose tolerance subjects without cardiovascular disease.	Blood Glucose	66-79	sucrase-isomaltase	Homo sapiens	13-30
25061309-1	2014	Acarbose is an alpha-glucosidase inhibitor that is commonly used to control postprandial blood glucose.	Blood Glucose	89-102	sucrase-isomaltase	Homo sapiens	15-32
24880489-0	2014	Novel synthesis of dihydropyrimidines for alpha-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking.	dihydropyrimidines	19-37	sucrase-isomaltase	Homo sapiens	42-59
24844449-0	2014	Synthesis and molecular docking studies of potent alpha-glucosidase inhibitors based on biscoumarin skeleton.	biscoumarin	88-99	sucrase-isomaltase	Homo sapiens	50-67
24844449-1	2014	In our effort directed toward the discovery of new anti-diabetic agent for the treatment of diabetes, a library of biscoumarin derivative 1-18 was synthesized and evaluated for alpha-glucosidase inhibitory potential.	biscoumarin	115-126	sucrase-isomaltase	Homo sapiens	177-194
24844449-2	2014	All eighteen (18) compounds displayed assorted alpha-glucosidase activity with IC50 values 16.5-385.9 muM, if compared with the standard acarbose (IC50 = 906 +- 6.387 muM).	Acarbose	137-145	sucrase-isomaltase	Homo sapiens	47-64
24897556-0	2014	Xanthohumol, a prenylated chalcone from beer hops, acts as an alpha-glucosidase inhibitor in vitro.	xanthohumol	0-11	sucrase-isomaltase	Homo sapiens	62-79
24897556-0	2014	Xanthohumol, a prenylated chalcone from beer hops, acts as an alpha-glucosidase inhibitor in vitro.	Chalcone	26-34	sucrase-isomaltase	Homo sapiens	62-79
24897556-3	2014	In the present study, a series of in vitro experiments were performed to investigate whether XN was an effective inhibitor of alpha-glucosidase.	xanthohumol	93-95	sucrase-isomaltase	Homo sapiens	126-143
24897556-4	2014	The results showed that XN inhibited alpha-glucosidase in a reversible and noncompetitive manner, with an IC50 value of 8.8 muM and that XN inhibited the release of glucose from the maltose in the apical side of the Caco-2 cell monolayer.	xanthohumol	24-26	sucrase-isomaltase	Homo sapiens	37-54
24897556-6	2014	These results demonstrated that XN is a promising alpha-glucosidase inhibitor, which therefore could be used as functional food to alleviate postprandial hyperglycemia and as a potential candidate for the development of an antidiabetic agent.	xanthohumol	32-34	sucrase-isomaltase	Homo sapiens	50-67
24798092-4	2014	The alpha-glucosidase inhibitor voglibose is widely used in Japan to improve postprandial hyperglycemia.	voglibose	32-41	sucrase-isomaltase	Homo sapiens	4-21
24766280-1	2014	The glucose oxidase/peroxidase assay (GOP) is a coupled enzymatic assay commonly used in measuring glucose concentrations in biological sciences and food chemistry, particularly for quantification of alpha-glucosidase activity.	Glucose	4-11	sucrase-isomaltase	Homo sapiens	200-217
24926379-7	2014	The combination therapy of vildagliptin plus an alpha-glucosidase inhibitor effectively reduced the FBG, PPG and HbA1c levels in patients without inducing weight gain or hepatorenal dysfunction.	ppg	105-108	sucrase-isomaltase	Homo sapiens	48-65
24519177-0	2014	The first convergent total synthesis of penarolide sulfate A2, a novel alpha-glucosidase inhibitor.	penarolide sulfate	40-58	sucrase-isomaltase	Homo sapiens	71-88
24742256-3	2014	Acarbose, like other alpha-glucosidase inhibitors (AGIs), has been proven to be an effective antidiabetic treatment for decades, but the overall significant impact of this class of drugs on modulating CV risk has only recently been appreciated.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	21-38
24519177-4	2014	The anti-yeast alpha-glucosidase activities of penarolide sulfate A2 and its fully desulfated derivative were examined showing IC50 values of 4.87 and 10.74 mug mL(-1), respectively.	penarolide sulfate	47-65	sucrase-isomaltase	Homo sapiens	15-32
24414220-6	2014	There are data on antimicrobial, antioxidant and immunomodulatory activities of cyclodidepsipeptides as well as their inhibitory activities toward alpha-glucosidase, acyl-CoA:cholesterol acyltransferase, xanthine oxidase and platelet aggregation.	cyclodidepsipeptides	80-100	sucrase-isomaltase	Homo sapiens	147-164
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Catechin	115-123	sucrase-isomaltase	Homo sapiens	51-68
24491460-0	2014	Potential alpha-glucosidase inhibitors from thermal transformation of (+)-catechin.	Catechin	70-82	sucrase-isomaltase	Homo sapiens	10-27
24491460-3	2014	The catechin dimers 2 and 3 exhibited significantly improved inhibitory activities against alpha-glucosidase, with IC50 values of 0.16+-0.2 and 0.14+-0.2muM, respectively, when compared to parent (+)-catechin.	Catechin	4-12	sucrase-isomaltase	Homo sapiens	91-108
24491460-3	2014	The catechin dimers 2 and 3 exhibited significantly improved inhibitory activities against alpha-glucosidase, with IC50 values of 0.16+-0.2 and 0.14+-0.2muM, respectively, when compared to parent (+)-catechin.	Catechin	196-208	sucrase-isomaltase	Homo sapiens	91-108
24412302-0	2014	Naringenin inhibits alpha-glucosidase activity: a promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats.	naringenin	0-10	sucrase-isomaltase	Homo sapiens	20-37
24412302-0	2014	Naringenin inhibits alpha-glucosidase activity: a promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats.	Streptozocin	139-153	sucrase-isomaltase	Homo sapiens	20-37
24412302-3	2014	Postprandial glucose levels can be regulated through alpha-glucosidase inhibition.	Glucose	13-20	sucrase-isomaltase	Homo sapiens	53-70
24412302-4	2014	The present study aims to demonstrate the potent inhibitory role of naringenin against alpha-glucosidase activity.	naringenin	68-78	sucrase-isomaltase	Homo sapiens	87-104
24412302-6	2014	It shows competitive inhibition towards mammalian alpha-glucosidase thereby competing with alpha-limit dextrins and oligosaccharide residues for binding in the active site.	Dextrins	103-111	sucrase-isomaltase	Homo sapiens	50-67
24412302-6	2014	It shows competitive inhibition towards mammalian alpha-glucosidase thereby competing with alpha-limit dextrins and oligosaccharide residues for binding in the active site.	Oligosaccharides	116-131	sucrase-isomaltase	Homo sapiens	50-67
24412302-7	2014	Similar results have been obtained from the molecular docking analyses, where naringenin shows preferential binding for the active sites in each of the evaluated human intestinal alpha-glucosidase enzymes.	naringenin	78-88	sucrase-isomaltase	Homo sapiens	179-196
24412302-10	2014	Further, our results suggest that naringenin (25 mg/kg) exerts significant inhibition of intestinal alpha-glucosidase activity in vivo thereby delaying the absorption of carbohydrates in T2D rats, thus resulting in significant lowering of postprandial blood glucose levels.	naringenin	34-44	sucrase-isomaltase	Homo sapiens	100-117
24412302-10	2014	Further, our results suggest that naringenin (25 mg/kg) exerts significant inhibition of intestinal alpha-glucosidase activity in vivo thereby delaying the absorption of carbohydrates in T2D rats, thus resulting in significant lowering of postprandial blood glucose levels.	Glucose	258-265	sucrase-isomaltase	Homo sapiens	100-117
24412302-11	2014	Both in vitro and in vivo results were compared to the commercially available alpha-glucosidase inhibitor acarbose.	Acarbose	106-114	sucrase-isomaltase	Homo sapiens	78-95
24508143-0	2014	Synthesis, nitric oxide release, and alpha-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives.	Nitric Oxide	69-81	sucrase-isomaltase	Homo sapiens	37-54
24508143-1	2014	alpha-Glucosidase (AG) play crucial roles in the digestion of carbohydrates.	Carbohydrates	62-75	sucrase-isomaltase	Homo sapiens	0-17
24508143-4	2014	Except for 9a-c, twelve compounds showed remarkable inhibitory activity against alpha-glucosidase, with potency being better than that of acarbose and 1-deoxynojirimycin.	Acarbose	138-146	sucrase-isomaltase	Homo sapiens	80-97
24508143-4	2014	Except for 9a-c, twelve compounds showed remarkable inhibitory activity against alpha-glucosidase, with potency being better than that of acarbose and 1-deoxynojirimycin.	1-DEOXYNOJIRIMYCIN	151-169	sucrase-isomaltase	Homo sapiens	80-97
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Catechin	136-144	sucrase-isomaltase	Homo sapiens	51-68
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Acarbose	148-156	sucrase-isomaltase	Homo sapiens	51-68
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	catechin-g	115-125	sucrase-isomaltase	Homo sapiens	51-68
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Acarbose	253-261	sucrase-isomaltase	Homo sapiens	51-68
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Catechin	136-144	sucrase-isomaltase	Homo sapiens	51-68
24333230-2	2014	Inhibition of alpha-glucosidase is important due to the potential effect of down regulating glucose absorption in patients.	Glucose	92-99	sucrase-isomaltase	Homo sapiens	14-31
24333230-3	2014	In this study, the inhibitory activity of flavone luteolin on alpha-glucosidase and their interaction mechanism were investigated by multispectroscopic methods along with molecular docking technique.	flavone	42-49	sucrase-isomaltase	Homo sapiens	62-79
24398385-2	2014	The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant alpha-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes.	acrabose	127-135	sucrase-isomaltase	Homo sapiens	74-91
25087634-0	2014	Synthesis and biological evaluation of 3-styrylchromone derivatives as free radical scavengers and alpha-glucosidase inhibitors.	3-styrylchromone	39-55	sucrase-isomaltase	Homo sapiens	99-116
24398385-0	2014	Synthesis of novel indenoquinoxaline derivatives as potent alpha-glucosidase inhibitors.	indenoquinoxaline	19-36	sucrase-isomaltase	Homo sapiens	59-76
23964564-3	2014	Then two retaining exoglucosidases, maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI), convert those molecules into glucose in the small intestine.	Glucose	122-129	sucrase-isomaltase	Homo sapiens	68-86
23964564-3	2014	Then two retaining exoglucosidases, maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI), convert those molecules into glucose in the small intestine.	Glucose	122-129	sucrase-isomaltase	Homo sapiens	88-90
24991576-1	2014	An in vitro antidiabetic activity on alpha -amylase and alpha -glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a-3f) were evaluated.	10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines	93-174	sucrase-isomaltase	Homo sapiens	56-74
25087634-1	2014	A series of 3-styrylchromone derivatives (4-20) were synthesized and the structure-activity relationships for alpha-glucosidase inhibition and antioxidant activities were analyzed.	3-styrylchromone	12-28	sucrase-isomaltase	Homo sapiens	110-127
25087634-2	2014	Among the synthesized compounds, compounds 15 and 20, which contain a catechol moiety, showed both potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (15: EC50=17 microM; 20: EC50=23 microM) and alpha-glucosidase inhibitory activity (15: IC50=16 microM; 20: IC50=10 microM).	catechol	70-78	sucrase-isomaltase	Homo sapiens	221-238
25087634-2	2014	Among the synthesized compounds, compounds 15 and 20, which contain a catechol moiety, showed both potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (15: EC50=17 microM; 20: EC50=23 microM) and alpha-glucosidase inhibitory activity (15: IC50=16 microM; 20: IC50=10 microM).	1,1-diphenyl-2-picrylhydrazyl	137-141	sucrase-isomaltase	Homo sapiens	221-238
25087634-3	2014	Our data suggest that 3-styrylchromone derivatives are novel alpha-glucosidase inhibitors that have the potential to counteract diet-induced hyperglycemia in diabetes.	3-styrylchromone	22-38	sucrase-isomaltase	Homo sapiens	61-78
25109946-3	2014	In clinical settings, the alpha-glucosidase inhibitors (alpha-GIs) glinides are often prescribed to prevent postprandial hyperglycemia.	glinides	67-75	sucrase-isomaltase	Homo sapiens	26-43
24225338-2	2014	alpha-Glucosidase inhibitors (alpha-GIs), which reduce post-prandial hyperglycemia without stimulating insulin secretion, significantly reduce the risk of coronary artery disease (CAD), whereas glinides, which improve post-prandial hyperglycemia through post-prandial insulin secretion, do not appear to affect CAD.	glinides	194-202	sucrase-isomaltase	Homo sapiens	0-17
23822979-5	2014	In addition, sucrase-isomaltase protein expression and uptake of beta-Ala-Lys-N-7-amino-4-methylcoumarin-3-acetic acid (beta-Ala-Lys-AMCA), a fluorescence-labeled substrate of the oligopeptide transporter, were detected.	alanyl-lysyl-amca	120-137	sucrase-isomaltase	Homo sapiens	13-31
24278452-10	2013	Inhibition of alpha-glucosidase and alpha-amylase can significantly decrease the postprandial hyperglycaemia after a mixed carbohydrate diet and therefore can be an important strategy in the management of postprandial blood glucose levels in NIDDM patients.	Carbohydrates	123-135	sucrase-isomaltase	Homo sapiens	14-31
24377104-0	2013	An integrated strategy of ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and virtual screening for the identification of alpha-glucosidase inhibitors in acarviostatin-containing complex.	acarviostatin	195-208	sucrase-isomaltase	Homo sapiens	163-180
24028850-13	2013	Consequently, this protein might be useful for delivery of PFH compounds to small intestine where representing their potential ability to inhibit alpha-Gls and to reduce the postprandial hyperglycemia in diabetic patients.	N-n-Propyl-N-formylhydrazine	59-62	sucrase-isomaltase	Homo sapiens	146-155
23870901-0	2013	Screening alpha-glucosidase inhibitor from natural products by capillary electrophoresis with immobilised enzyme onto polymer monolith modified by gold nanoparticles.	Polymers	118-125	sucrase-isomaltase	Homo sapiens	10-27
23870901-2	2013	In this approach, gold nanoparticles (AuNPs) was first covalently attached to surface of the pores of the porous polymer capillary monolith via the formation of an Au-S bond, and alpha-glucosidase was then simply and stably immobilised onto AuNPs through the strong affinity of gold for amino groups of the enzyme.	Polymers	113-120	sucrase-isomaltase	Homo sapiens	179-196
24028850-3	2013	Recently, pyrimidine fused heterocycles (PFHs) revealed inhibitory properties against alpha-glucosidase (alpha-Gls) which is an important target enzyme for those drugs playing significant role in treatment of type-II diabetes and HIV/AIDS infection.	pyrimidine	10-20	sucrase-isomaltase	Homo sapiens	86-103
24028850-3	2013	Recently, pyrimidine fused heterocycles (PFHs) revealed inhibitory properties against alpha-glucosidase (alpha-Gls) which is an important target enzyme for those drugs playing significant role in treatment of type-II diabetes and HIV/AIDS infection.	pyrimidine	10-20	sucrase-isomaltase	Homo sapiens	105-114
24551718-0	2013	Voglibose: an alpha glucosidase inhibitor.	voglibose	0-9	sucrase-isomaltase	Homo sapiens	14-31
24551718-4	2013	Alpha glucosidase inhibitors, namely acarbose, voglibose and miglitol, are available for therapy.	Acarbose	37-45	sucrase-isomaltase	Homo sapiens	0-17
24551718-4	2013	Alpha glucosidase inhibitors, namely acarbose, voglibose and miglitol, are available for therapy.	voglibose	47-56	sucrase-isomaltase	Homo sapiens	0-17
24551718-4	2013	Alpha glucosidase inhibitors, namely acarbose, voglibose and miglitol, are available for therapy.	miglitol	61-69	sucrase-isomaltase	Homo sapiens	0-17
23009660-5	2013	11-O-(3",4"-dimethoxybenzoyl)-bergenin was noncompetitive inhibitor for alpha-glucosidase.	11-o-(3",4"-dimethoxybenzoyl)-bergenin	0-38	sucrase-isomaltase	Homo sapiens	72-89
24278452-10	2013	Inhibition of alpha-glucosidase and alpha-amylase can significantly decrease the postprandial hyperglycaemia after a mixed carbohydrate diet and therefore can be an important strategy in the management of postprandial blood glucose levels in NIDDM patients.	Glucose	224-231	sucrase-isomaltase	Homo sapiens	14-31
24068167-13	2013	Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P &lt; .05 for all).	teduglutide	0-11	sucrase-isomaltase	Homo sapiens	151-169
23978663-0	2013	Synthesis of new pyrimidine-fused derivatives as potent and selective antidiabetic alpha-glucosidase inhibitors.	pyrimidine	17-27	sucrase-isomaltase	Homo sapiens	83-100
24076198-7	2013	Notably, GA-g-chitosan showed increased alpha-glucosidase and alpha-amylase inhibitory activity with the increase of grafting ratio.	gallic acid-g-chitosan	9-22	sucrase-isomaltase	Homo sapiens	40-57
23978663-1	2013	The synthesis of a set of pyrimidine-fused derivatives (L1-L8), resulting from the incorporation of different fragments on the pyrimidine-fused heterocycle (PFH) of the earlier reported alpha-glucosidase (alpha-Gls) inhibitor (C1-C5), allowed the discovery of new ligands with modest and selective inhibitory activity.	pyrimidine	26-36	sucrase-isomaltase	Homo sapiens	186-203
23978663-1	2013	The synthesis of a set of pyrimidine-fused derivatives (L1-L8), resulting from the incorporation of different fragments on the pyrimidine-fused heterocycle (PFH) of the earlier reported alpha-glucosidase (alpha-Gls) inhibitor (C1-C5), allowed the discovery of new ligands with modest and selective inhibitory activity.	pyrimidine	26-36	sucrase-isomaltase	Homo sapiens	205-214
24051476-0	2013	Combined effects of green tea extracts, green tea polyphenols or epigallocatechin gallate with acarbose on inhibition against alpha-amylase and alpha-glucosidase in vitro.	epigallocatechin gallate	65-89	sucrase-isomaltase	Homo sapiens	144-161
24399866-1	2013	Glycogen-storage disease type II, also named Pompe disease, is caused by the deficiency of the enzyme acid alpha-glucosidase, which originates lysosomal glycogen accumulation leading to progressive neuromuscular damage.	Glycogen	153-161	sucrase-isomaltase	Homo sapiens	107-124
24294470-3	2013	METHODS: In vitro enzymatic carbohydrate digestion with PbBLE and arbutin was assessed using alpha-amylase and alpha-glucosidase powders.	Carbohydrates	28-40	sucrase-isomaltase	Homo sapiens	111-128
24251196-0	2013	Alpha-glucosidase inhibitor, acarbose, improves glycamic control and reduces body weight in type 2 diabetes: Findings on indian patients from the pooled data analysis.	Acarbose	29-37	sucrase-isomaltase	Homo sapiens	0-17
23361306-3	2013	Some of them showed much stronger inhibitory activity towards alpha-glucosidase than the positive control (acarbose, IC50 10.2 muM).	Acarbose	107-115	sucrase-isomaltase	Homo sapiens	62-79
24051476-0	2013	Combined effects of green tea extracts, green tea polyphenols or epigallocatechin gallate with acarbose on inhibition against alpha-amylase and alpha-glucosidase in vitro.	Acarbose	95-103	sucrase-isomaltase	Homo sapiens	144-161
24051476-1	2013	Green tea, green tea polyphenols and epigallocatechin gallate (EGCG) are confirmed to have beneficial effects in the treatment of diabetes mellitus, and a possible mechanism can be ascribed to their inhibitory effect against alpha-amylase and alpha-glucosidase in the digestive tract.	Polyphenols	21-32	sucrase-isomaltase	Homo sapiens	243-260
24051476-1	2013	Green tea, green tea polyphenols and epigallocatechin gallate (EGCG) are confirmed to have beneficial effects in the treatment of diabetes mellitus, and a possible mechanism can be ascribed to their inhibitory effect against alpha-amylase and alpha-glucosidase in the digestive tract.	epigallocatechin gallate	37-61	sucrase-isomaltase	Homo sapiens	243-260
24051476-1	2013	Green tea, green tea polyphenols and epigallocatechin gallate (EGCG) are confirmed to have beneficial effects in the treatment of diabetes mellitus, and a possible mechanism can be ascribed to their inhibitory effect against alpha-amylase and alpha-glucosidase in the digestive tract.	epigallocatechin gallate	63-67	sucrase-isomaltase	Homo sapiens	243-260
24051476-2	2013	In this paper, we first investigated the combined inhibitory effect of green tea extracts, green tea polyphenols or EGCG with acarbose on alpha-amylase and alpha-glucosidase in vitro.	Polyphenols	101-112	sucrase-isomaltase	Homo sapiens	156-173
24051476-2	2013	In this paper, we first investigated the combined inhibitory effect of green tea extracts, green tea polyphenols or EGCG with acarbose on alpha-amylase and alpha-glucosidase in vitro.	epigallocatechin gallate	116-120	sucrase-isomaltase	Homo sapiens	156-173
24051476-2	2013	In this paper, we first investigated the combined inhibitory effect of green tea extracts, green tea polyphenols or EGCG with acarbose on alpha-amylase and alpha-glucosidase in vitro.	Acarbose	126-134	sucrase-isomaltase	Homo sapiens	156-173
24051476-4	2013	The combination of green tea extracts, green tea polyphenols or EGCG with acarbose had a synergistic effect on alpha-amylase and alpha-glucosidase at low concentrations and the combined effect turned out to be antagonistic at high concentrations according to the Combination Index (CI) values.	Polyphenols	49-60	sucrase-isomaltase	Homo sapiens	129-146
24051476-4	2013	The combination of green tea extracts, green tea polyphenols or EGCG with acarbose had a synergistic effect on alpha-amylase and alpha-glucosidase at low concentrations and the combined effect turned out to be antagonistic at high concentrations according to the Combination Index (CI) values.	epigallocatechin gallate	64-68	sucrase-isomaltase	Homo sapiens	129-146
24051476-4	2013	The combination of green tea extracts, green tea polyphenols or EGCG with acarbose had a synergistic effect on alpha-amylase and alpha-glucosidase at low concentrations and the combined effect turned out to be antagonistic at high concentrations according to the Combination Index (CI) values.	Acarbose	74-82	sucrase-isomaltase	Homo sapiens	129-146
23909841-5	2013	The interactions between ligands and alpha-glucosidase were mainly driven by hydrophobic force, or hydrogen bonding consequently induced conformational changes and reduced surface hydrophobicity.	Hydrogen	99-107	sucrase-isomaltase	Homo sapiens	37-54
23910991-0	2013	N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid a novel scaffold for the design of uncompetitive alpha-glucosidase inhibitors.	n-heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid	0-73	sucrase-isomaltase	Homo sapiens	123-140
23910991-1	2013	The enzyme alpha-glucosidase has attracted interest owing to its involvement in the digestive process of carbohydrate, its role in intracellular glycoprotein trafficking, tumorigenesis and viral infection.	Carbohydrates	105-117	sucrase-isomaltase	Homo sapiens	11-28
23910991-2	2013	In this study, several members of a new family of N-heteroarylmethyl substituted azasugars were synthesized and evaluated as alpha-glucosidase inhibitors.	n-heteroarylmethyl substituted azasugars	50-90	sucrase-isomaltase	Homo sapiens	125-142
23910991-4	2013	The compounds N-heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid emerged as potent alpha-glucosidase inhibitors.	n-heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid	14-87	sucrase-isomaltase	Homo sapiens	106-123
23880081-6	2013	The new 2,5-dideoxy-2,5-imino-d-mannitol (DMDP)-based iminosugar 22 was found to exhibit a satisfactory chaperoning activity to enhance GCase activity by 2.2-fold in Gaucher N370S cell line, without impairment of cellular alpha-glucosidase activity.	2,5-dideoxy-2,5-imino-D-mannitol	8-40	sucrase-isomaltase	Homo sapiens	222-239
23880081-6	2013	The new 2,5-dideoxy-2,5-imino-d-mannitol (DMDP)-based iminosugar 22 was found to exhibit a satisfactory chaperoning activity to enhance GCase activity by 2.2-fold in Gaucher N370S cell line, without impairment of cellular alpha-glucosidase activity.	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	42-46	sucrase-isomaltase	Homo sapiens	222-239
23880081-6	2013	The new 2,5-dideoxy-2,5-imino-d-mannitol (DMDP)-based iminosugar 22 was found to exhibit a satisfactory chaperoning activity to enhance GCase activity by 2.2-fold in Gaucher N370S cell line, without impairment of cellular alpha-glucosidase activity.	Imino Sugars	54-64	sucrase-isomaltase	Homo sapiens	222-239
23909841-7	2013	This work provides useful information for the understanding of the ligands-alpha-glucosidase interactions and identifies oxyresveratrol as a potent alpha-glucosidase inhibitor.	puag-haad	121-135	sucrase-isomaltase	Homo sapiens	148-165
23909841-7	2013	This work provides useful information for the understanding of the ligands-alpha-glucosidase interactions and identifies oxyresveratrol as a potent alpha-glucosidase inhibitor.	puag-haad	121-135	sucrase-isomaltase	Homo sapiens	75-92
23879813-4	2013	Voglibose is a representative antidiabetic drug possessing inhibitory activity towards human alpha-glucosidase; it blocked the proper N-glycan modification of tyrosinase, resulting in a dramatic reduction of the tyrosinase protein level by altering its stability and subsequently decreasing melanin production.	voglibose	0-9	sucrase-isomaltase	Homo sapiens	93-110
23778751-0	2013	Development of alpha-glucosidase inhibitors by room temperature C-C cross couplings of quinazolinones.	Quinazolinones	87-101	sucrase-isomaltase	Homo sapiens	15-32
23778751-1	2013	Novel quinazolinone based alpha-glucosidase inhibitors have been developed.	Quinazolinones	6-19	sucrase-isomaltase	Homo sapiens	26-43
23778751-2	2013	For this purpose a virtual screening model has been generated and validated utilizing acarbose as a alpha-glucosidase inhibitor.	Acarbose	86-94	sucrase-isomaltase	Homo sapiens	100-117
23582447-5	2013	Increasing alkyl linker length between DNJ and triazole groups increases alpha-glucosidase inhibition and reduces the production of viral progeny RNA and the maturation of the envelope polypeptide.	1-Deoxynojirimycin	39-42	sucrase-isomaltase	Homo sapiens	73-90
23582447-5	2013	Increasing alkyl linker length between DNJ and triazole groups increases alpha-glucosidase inhibition and reduces the production of viral progeny RNA and the maturation of the envelope polypeptide.	Triazoles	47-55	sucrase-isomaltase	Homo sapiens	73-90
23879813-6	2013	Considering that voglibose was originally selected from the valiolamine derivatives in a screen for an oral antidiabetic drug with a strong inhibitory activity towards intestinal alpha-glucosidase and low cell permeability, we propose an alternative strategy for screening compounds from valiolamine derivatives that show high inhibitory activity towards human intracellular alpha-glucosidases and high cell permeability, with the goal of obtaining antimelanogenic agents that are effective inside the cells.	voglibose	17-26	sucrase-isomaltase	Homo sapiens	179-196
23642288-1	2013	BACKGROUND: Treatment with the alpha-glucosidase inhibitor (AGI) acarbose is associated with a significant reduction the risk of cardiovascular events.	Acarbose	65-73	sucrase-isomaltase	Homo sapiens	31-48
23805995-0	2013	Xanthone glycoside constituents of Swertia kouitchensis with alpha-glucosidase inhibitory activity.	xanthone glycoside	0-18	sucrase-isomaltase	Homo sapiens	61-78
24843685-0	2013	Efficacy of alpha-glucosidase inhibitors combined with dipeptidyl-peptidase-4 inhibitor (alogliptin) for glucose fluctuation in patients with type 2 diabetes mellitus by continuous glucose monitoring.	Glucose	105-112	sucrase-isomaltase	Homo sapiens	12-29
23355366-2	2013	Among the 10 fatty acids analyzed, oleic acid showed the strongest anti-alpha-glucosidase activity, followed by linoleic acid, and their activities were more potent than acarbose, but they possessed a weaker anti-alpha-amylase activity.	Fatty Acids	13-24	sucrase-isomaltase	Homo sapiens	72-89
23355366-2	2013	Among the 10 fatty acids analyzed, oleic acid showed the strongest anti-alpha-glucosidase activity, followed by linoleic acid, and their activities were more potent than acarbose, but they possessed a weaker anti-alpha-amylase activity.	Oleic Acid	35-45	sucrase-isomaltase	Homo sapiens	72-89
23355366-3	2013	Kinetic assays demonstrated that oleic acid and linoleic acid were competitive inhibitors, and their interactions with alpha-glucosidase exhibited a character of static quenching, which indicates that they would bind to alpha-glucosidase to form a complex.	Oleic Acid	33-43	sucrase-isomaltase	Homo sapiens	119-136
23355366-3	2013	Kinetic assays demonstrated that oleic acid and linoleic acid were competitive inhibitors, and their interactions with alpha-glucosidase exhibited a character of static quenching, which indicates that they would bind to alpha-glucosidase to form a complex.	Oleic Acid	33-43	sucrase-isomaltase	Homo sapiens	220-237
23355366-3	2013	Kinetic assays demonstrated that oleic acid and linoleic acid were competitive inhibitors, and their interactions with alpha-glucosidase exhibited a character of static quenching, which indicates that they would bind to alpha-glucosidase to form a complex.	Linoleic Acid	48-61	sucrase-isomaltase	Homo sapiens	119-136
23355366-3	2013	Kinetic assays demonstrated that oleic acid and linoleic acid were competitive inhibitors, and their interactions with alpha-glucosidase exhibited a character of static quenching, which indicates that they would bind to alpha-glucosidase to form a complex.	Linoleic Acid	48-61	sucrase-isomaltase	Homo sapiens	220-237
23355366-6	2013	Taken together, these results conclude that oleic acid and linoleic acid possess potent inhibitory effects on alpha-glucosidase activity.	Oleic Acid	44-54	sucrase-isomaltase	Homo sapiens	110-127
23355366-6	2013	Taken together, these results conclude that oleic acid and linoleic acid possess potent inhibitory effects on alpha-glucosidase activity.	Linoleic Acid	59-72	sucrase-isomaltase	Homo sapiens	110-127
23600363-0	2013	Glycemic control after addition of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes showing inadequate response to thrice-a-day treatment with alpha-glucosidase inhibitors.	alogliptin	72-82	sucrase-isomaltase	Homo sapiens	175-192
24471122-7	2013	Broccoli juice prepared by method I had the highest alpha-glucosidase inhibitory effects.	broccoli juice	0-14	sucrase-isomaltase	Homo sapiens	52-69
23718315-14	2013	The water fraction of BF showed the highest percentage of alpha-glucosidase inhibition while having the highest amount of protein (73.33 +- 4.99 mug/mg fraction).	Water	4-9	sucrase-isomaltase	Homo sapiens	58-75
23651430-0	2013	alpha-Glucosidase inhibiton and antiglycation activity of laccase-catalyzed catechin polymers.	catechin polymers	76-93	sucrase-isomaltase	Homo sapiens	0-17
23651430-3	2013	Catechin polymers extracted with 20% ethanol had potent inhibitory activity against alpha-glucosidase with an IC50 value of 4 mug/mL, and they were present as a mixture of dimers, trimers, and tetramers.	Catechin	0-8	sucrase-isomaltase	Homo sapiens	84-101
23651430-3	2013	Catechin polymers extracted with 20% ethanol had potent inhibitory activity against alpha-glucosidase with an IC50 value of 4 mug/mL, and they were present as a mixture of dimers, trimers, and tetramers.	Ethanol	37-44	sucrase-isomaltase	Homo sapiens	84-101
23419323-3	2013	Pyrrolidine-3,4-diol 15a and pyrrolidine-3,4-diol diacetate 15b had emerged as the most potent alpha-glucosidase inhibitors in the series.	Pyrrolidine-3,4-diol	0-20	sucrase-isomaltase	Homo sapiens	95-112
23638112-1	2013	Starch digestion in the human body is typically viewed in a sequential manner beginning with alpha-amylase and followed by alpha-glucosidase to produce glucose.	Starch	0-6	sucrase-isomaltase	Homo sapiens	123-140
23474902-0	2013	Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as alpha-glucosidase inhibitors.	Triterpenes	19-29	sucrase-isomaltase	Homo sapiens	76-93
23474902-0	2013	Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as alpha-glucosidase inhibitors.	n-allylated/n-alkylated niacin	34-64	sucrase-isomaltase	Homo sapiens	76-93
23474902-2	2013	alpha-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels.	Glucose	106-115	sucrase-isomaltase	Homo sapiens	0-17
23474902-2	2013	alpha-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels.	Oligosaccharides	121-137	sucrase-isomaltase	Homo sapiens	0-17
23474902-2	2013	alpha-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels.	Disaccharides	142-155	sucrase-isomaltase	Homo sapiens	0-17
23474902-2	2013	alpha-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels.	Glucose	108-115	sucrase-isomaltase	Homo sapiens	0-17
23474902-2	2013	alpha-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels.	Glucose	178-185	sucrase-isomaltase	Homo sapiens	0-17
23474902-4	2013	Compounds 4-9 showed better activity profile than the marketed alpha-glucosidase inhibitor i.e. acarbose.	Acarbose	96-104	sucrase-isomaltase	Homo sapiens	63-80
23474902-6	2013	Kinetic and CD studies revealed that 4 inhibited the alpha-glucosidase in a noncompetitive manner and caused conformational changes in secondary structure of the enzyme protein.	Cadmium	12-14	sucrase-isomaltase	Homo sapiens	53-70
23419323-3	2013	Pyrrolidine-3,4-diol 15a and pyrrolidine-3,4-diol diacetate 15b had emerged as the most potent alpha-glucosidase inhibitors in the series.	pyrrolidine-3,4-diol diacetate	29-59	sucrase-isomaltase	Homo sapiens	95-112
23419323-4	2013	Docking studies performed with an homology model of alpha-glucosidase disclosed binding poses for compounds 15a, 15b, 16a, and 16a" occupying the same region as the NH group of the terminal ring of acarbose and suggest a closer and stronger binding of compound 15a and 15b with the enzyme active site residues.	Acarbose	198-206	sucrase-isomaltase	Homo sapiens	52-69
23795478-8	2013	Active alpha-glucosidase inhibitor was isolated from Streptomyces strain PW638 fermentation broth and identified as acarviostatin 103 by MS and N MR spectrometry.	acarviostatin 103	116-133	sucrase-isomaltase	Homo sapiens	7-24
23700798-0	2013	alpha-Glucosidase and alpha-amylase inhibitory activities of saponins from traditional Chinese medicines in the treatment of diabetes mellitus.	Saponins	61-69	sucrase-isomaltase	Homo sapiens	0-17
23700798-5	2013	The results revealed that saponins 2, 3, 4 (IC50: 0.83 +/- 0.05 microM for BSG and IC50: 0.72 +/- 0.03 microM for SCG), 5, 6, 7, 9, 10, 11 and 12 (IC50: 1.07 +/- 0.04 micro.M for BSG and IC50: 0.93 +/- 0.05 micro.M for SCG) showed alpha-glucosidase inhibitory activities, while 2, 3, 4 (IC50: 0.93 +/- 0.04 micro.M for PPA), 5, 6, 7, 9, 10, 11 and 12 (IC50: 1.02 +/- 0.03 micro.M for PPA) possessed significant alpha-amylase inhibitory activities.	Saponins	26-34	sucrase-isomaltase	Homo sapiens	231-248
23700798-7	2013	It is suggested that the glucuronic acid unit at C-3 of the aglycone is the imperative functional group of the antidiabetic activities, and two characteristic structural features are responsible for the remarkable alpha-glucosidase and alpha-amylase inhibitory activities.	Glucuronic Acid	25-40	sucrase-isomaltase	Homo sapiens	214-231
23700798-7	2013	It is suggested that the glucuronic acid unit at C-3 of the aglycone is the imperative functional group of the antidiabetic activities, and two characteristic structural features are responsible for the remarkable alpha-glucosidase and alpha-amylase inhibitory activities.	CHEBI:166892	60-68	sucrase-isomaltase	Homo sapiens	214-231
23131646-0	2013	Enzymatic analyses demonstrate thermal adaptation of alpha-glucosidase activity in starch amended gully waste.	Starch	83-89	sucrase-isomaltase	Homo sapiens	53-70
23131646-1	2013	In this study we investigated the effect of starch amendment on alpha-glucosidase activity in an organic waste environment, treated under both mesophilic and thermophilic conditions.	Starch	44-50	sucrase-isomaltase	Homo sapiens	64-81
23649262-1	2013	Since the discovery of alpha-glucosidase inhibitors and their inhibitory effects on the digestion of carbohydrates, promising results have been obtained as to the antidiabetic effects of this family of compounds.	Carbohydrates	101-114	sucrase-isomaltase	Homo sapiens	23-40
23131646-4	2013	The results of extra-cellular enzyme analysis showed a significant relationship between starch addition and alpha-glucosidase activity, with evidence of thermal adaptation to the in situ temperature.	Starch	88-94	sucrase-isomaltase	Homo sapiens	108-125
23649262-4	2013	On this basis, this review describes studies of alpha-glucosidase inhibition by mulberry 1-deoxynojirimycin, antiangiogenic effects of rice bran tocotrienol, and membrane lipid peroxidation/glycation and its inhibitors.	1-DEOXYNOJIRIMYCIN	89-107	sucrase-isomaltase	Homo sapiens	48-65
23106358-0	2012	alpha-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral alpha-glucosidase inhibitor for improving postprandial hyperglycemia.	alpha-1-C-butyl-1,4-dideoxy-1,4-imino-L-arabinitol	0-50	sucrase-isomaltase	Homo sapiens	96-113
24177357-1	2013	A new series of thiazolidinedione derivatives were synthesized and evaluated for in vitro alpha-glucosidase inhibition and anticancer activities.	2,4-thiazolidinedione	16-33	sucrase-isomaltase	Homo sapiens	90-107
23565164-0	2013	Enzyme-synthesized highly branched maltodextrins have slow glucose generation at the mucosal alpha-glucosidase level and are slowly digestible in vivo.	maltodextrin	35-48	sucrase-isomaltase	Homo sapiens	93-110
23565164-0	2013	Enzyme-synthesized highly branched maltodextrins have slow glucose generation at the mucosal alpha-glucosidase level and are slowly digestible in vivo.	Glucose	59-66	sucrase-isomaltase	Homo sapiens	93-110
23137433-3	2012	IC(50) values of the compounds were compared with the known glucosidase inhibitor acarbose and it was determined that newly synthesized indole conduritols had more powerful effect against beta-glucosidase in addition to exhibiting moderate influence against alpha-glucosidase.	indole	136-142	sucrase-isomaltase	Homo sapiens	258-275
23190343-0	2012	A prospect for pyrrolidine iminosugars as antidiabetic alpha-glucosidase inhibitors.	pyrrolidine iminosugars	15-38	sucrase-isomaltase	Homo sapiens	55-72
23648711-10	2013	An analysis of the effects of various glucose-lowering therapies in the diabetic patients revealed the use of alpha-glucosidase inhibitors to be associated with a lower risk of hepatic cancer (adjusted HR, 0.62; 95% CI, 0.4-0.94).	Glucose	38-45	sucrase-isomaltase	Homo sapiens	110-127
23106358-0	2012	alpha-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral alpha-glucosidase inhibitor for improving postprandial hyperglycemia.	Imino Sugars	74-84	sucrase-isomaltase	Homo sapiens	96-113
22953807-1	2012	Polyphenol-rich extracts from certain berries inhibited alpha-glucosidase activity in vitro.	Polyphenols	0-10	sucrase-isomaltase	Homo sapiens	56-73
23159880-6	2012	We used this uncapping enzyme together with alpha-mannosidase to produce in yeast a form of the Pompe disease enzyme alpha-glucosidase rich in mannose-6-phosphate.	mannose-6-phosphate	143-162	sucrase-isomaltase	Homo sapiens	117-134
22990675-0	2012	Pharmacological enhancement of alpha-glucosidase by the allosteric chaperone N-acetylcysteine.	Acetylcysteine	77-93	sucrase-isomaltase	Homo sapiens	31-48
23159880-7	2012	Compared with the currently used therapeutic version, this form of alpha-glucosidase was more efficiently taken up by fibroblasts from Pompe disease patients, and it more effectively reduced cardiac muscular glycogen storage in a mouse model of the disease.	Glycogen	208-216	sucrase-isomaltase	Homo sapiens	67-84
22988246-0	2012	Starch source influences dietary glucose generation at the mucosal alpha-glucosidase level.	Starch	0-6	sucrase-isomaltase	Homo sapiens	67-84
23103656-0	2012	Direct starch digestion by sucrase-isomaltase and maltase-glucoamylase.	Starch	7-13	sucrase-isomaltase	Homo sapiens	27-45
23217597-6	2012	RESULTS: Although metformin remained the mainstay of anti-diabetic treatment, patients receiving combination therapy of oral glucose-lowering agents, either with or without insulin, significantly increased, from approximately 40% in 2000 to 60% in 2009, particularly in relation to the newer agents, including glinides, alpha-glucosidase inhibitors, and long-acting insulin analogues.	Glucose	125-132	sucrase-isomaltase	Homo sapiens	320-337
22512582-6	2012	The X-ray crystallography studies have been revealed that Alogliptin binds to DPP-IV active site by non-covalently and provides sustained reduction of plasma DPP-IV activity as well as lowering of blood glucose, in drug-naive patients with T2DM and inadequate glycemic control, once daily oral dosing regimen with varying levels of doses ranging from 25-800 mg. Alogliptin is approved as monotherapy and in combination with alpha-glucosidase &amp; thiazolidinediones.	alogliptin	58-68	sucrase-isomaltase	Homo sapiens	424-441
22389182-6	2012	While all the isolated compounds did show a variable degree of radical scavenging effect, 11-O-galloylbergenin was identified as the selective alpha-glucosidase inhibitor.	11-O-galloylbergenin	90-110	sucrase-isomaltase	Homo sapiens	143-160
22988246-0	2012	Starch source influences dietary glucose generation at the mucosal alpha-glucosidase level.	Glucose	33-40	sucrase-isomaltase	Homo sapiens	67-84
22988246-4	2012	There are six digestive enzymes for starch: salivary and pancreatic alpha-amylases and four mucosal alpha-glucosidases, including N- and C-terminal subunits of both maltase-glucoamylase and sucrase-isomaltase.	Starch	36-42	sucrase-isomaltase	Homo sapiens	190-208
22988246-8	2012	The alpha-LDx, which were derived from different maize cultivars, were not all equally digested, revealing that the starch source influences glucose generation at the mucosal alpha-glucosidase level.	Starch	116-122	sucrase-isomaltase	Homo sapiens	175-192
22988246-8	2012	The alpha-LDx, which were derived from different maize cultivars, were not all equally digested, revealing that the starch source influences glucose generation at the mucosal alpha-glucosidase level.	Glucose	141-148	sucrase-isomaltase	Homo sapiens	175-192
23351720-7	2012	RESULTS: A methanolic extract from flowering aerial parts of the plant showed notable alpha-glucosidase inhibitory activity (IC50 = 15 mug/ml).	methanolic	11-21	sucrase-isomaltase	Homo sapiens	86-103
22292767-1	2012	The natural flavonoids as human digestive enzymes, such as alpha-glucosidase, alpha-amylase and aldose reductases inhibitors, have attracted great interest among researchers.	Flavonoids	12-22	sucrase-isomaltase	Homo sapiens	59-76
22292767-12	2012	The methylation and methoxylation of flavonoids obviously affected the inhibitory effect for alpha-glucosidase in vitro depending on the replaced site.	Flavonoids	37-47	sucrase-isomaltase	Homo sapiens	93-110
22697360-0	2012	Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of alpha-amylase and alpha-glucosidase activity.	catechin 3-gallates	32-51	sucrase-isomaltase	Homo sapiens	95-112
22697360-5	2012	Whereas tea extracts and catechin 3-gallates were less effective inhibitors of alpha-amylase, they were potent inhibitors of alpha-glucosidase.	catechin 3-gallates	25-44	sucrase-isomaltase	Homo sapiens	125-142
22697360-7	2012	The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of alpha-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit alpha-amylase activity.	catechin 3-gallates	45-64	sucrase-isomaltase	Homo sapiens	131-148
22697360-7	2012	The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of alpha-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit alpha-amylase activity.	epigallocatechin gallate	80-104	sucrase-isomaltase	Homo sapiens	131-148
22697360-7	2012	The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of alpha-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit alpha-amylase activity.	Proanthocyanidins	175-187	sucrase-isomaltase	Homo sapiens	131-148
21899493-1	2012	In the present investigation, a QSAR analysis on structurally diverse alpha-glucosidase inhibitors (andrographolide, chromenone, triazole derivatives) was performed and the developed models were validated by various validation methods (LMO, LOO, LSO, bootstrapping, Y-randomization and test set).	andrographolide	100-115	sucrase-isomaltase	Homo sapiens	70-87
21899493-1	2012	In the present investigation, a QSAR analysis on structurally diverse alpha-glucosidase inhibitors (andrographolide, chromenone, triazole derivatives) was performed and the developed models were validated by various validation methods (LMO, LOO, LSO, bootstrapping, Y-randomization and test set).	coumarin	117-127	sucrase-isomaltase	Homo sapiens	70-87
21899493-1	2012	In the present investigation, a QSAR analysis on structurally diverse alpha-glucosidase inhibitors (andrographolide, chromenone, triazole derivatives) was performed and the developed models were validated by various validation methods (LMO, LOO, LSO, bootstrapping, Y-randomization and test set).	Triazoles	129-137	sucrase-isomaltase	Homo sapiens	70-87
23016254-1	2012	Detailed imaging studies of gas cysts in the intestinal mucosa (pneumatosis cystoides intestinalis) have been reported in around 20 patients taking acarbose, miglitolor voglibose, i.e. intestinal alpha-glucosidase inhibitors used as hypoglycaemic agents.	Acarbose	148-156	sucrase-isomaltase	Homo sapiens	196-213
22841093-3	2012	As a result, deoxynojirimycin, as a potential alpha-glucosidase inhibitor, was found.	1-Deoxynojirimycin	13-29	sucrase-isomaltase	Homo sapiens	46-63
22364273-3	2012	Other faecal glycosidase activities showed little or no change over a fivefold range of dietary NSP intake, although alpha-glucosidase increased on a resistant starch-enriched diet.	Starch	160-166	sucrase-isomaltase	Homo sapiens	117-134
22823570-0	2012	Novel fluorescent biosensor for alpha-glucosidase inhibitor screening based on cationic conjugated polymers.	Polymers	99-107	sucrase-isomaltase	Homo sapiens	32-49
22823570-2	2012	The fluorescence of cationic poly(fluorenylene phenylene) (PFP) was quenched in the presence of para-nitrophenyl-alpha-d-glucopyranoside and alpha-glucosidase, and turned on upon addition of AGIs.	poly(fluorenylene phenylene)	29-57	sucrase-isomaltase	Homo sapiens	141-158
22823570-2	2012	The fluorescence of cationic poly(fluorenylene phenylene) (PFP) was quenched in the presence of para-nitrophenyl-alpha-d-glucopyranoside and alpha-glucosidase, and turned on upon addition of AGIs.	pfp	59-62	sucrase-isomaltase	Homo sapiens	141-158
22322880-8	2012	We also found a significantly negative correlation between alpha-glucosidase activity and the levels of As (r = -0.367, P = 0.023).	Arsenic	104-106	sucrase-isomaltase	Homo sapiens	59-76
25114552-1	2012	Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2""-O-alpha-D-glucoside, was achieved by using alpha-glucosidase as a biocatalyst.	glycolyl-ester	29-43	sucrase-isomaltase	Homo sapiens	143-160
25114552-1	2012	Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2""-O-alpha-D-glucoside, was achieved by using alpha-glucosidase as a biocatalyst.	taxol-glucose	51-64	sucrase-isomaltase	Homo sapiens	143-160
25114552-1	2012	Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2""-O-alpha-D-glucoside, was achieved by using alpha-glucosidase as a biocatalyst.	7-glycolyltaxol 2""-o-alpha-d-glucoside	80-119	sucrase-isomaltase	Homo sapiens	143-160
22508699-4	2012	On the contrary, significant beneficial cardiovascular outcome results have been observed in the post-hoc analyses of randomised placebo-controlled trials with the alpha-glucosidase inhibitor acarbose.	Acarbose	192-200	sucrase-isomaltase	Homo sapiens	164-181
22519736-0	2012	Differential effects of alpha-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50.	Glucose	76-83	sucrase-isomaltase	Homo sapiens	24-41
22161170-2	2012	Acarbose, an alpha-glucosidase inhibitor (AGI), is employed in its treatment.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
24061235-2	2012	alpha-glucosidase (EC 3.2.1.20) is an essential enzyme that helps to digestion of carbohydrates such as starch and sugar.	Carbohydrates	82-95	sucrase-isomaltase	Homo sapiens	0-17
24061235-2	2012	alpha-glucosidase (EC 3.2.1.20) is an essential enzyme that helps to digestion of carbohydrates such as starch and sugar.	Starch	104-110	sucrase-isomaltase	Homo sapiens	0-17
24061235-2	2012	alpha-glucosidase (EC 3.2.1.20) is an essential enzyme that helps to digestion of carbohydrates such as starch and sugar.	Sugars	115-120	sucrase-isomaltase	Homo sapiens	0-17
24061235-4	2012	Therefore, alpha-glucosidase inhibitors can be used to decrease the blood sugar level.	Sugars	74-79	sucrase-isomaltase	Homo sapiens	11-28
22574444-1	2012	MeOH extracts of 37 herbs were tested in screening experiments for rat intestinal alpha-glucosidase.	Methanol	0-4	sucrase-isomaltase	Homo sapiens	82-99
22170377-8	2012	The thermal stability of both GCR and alpha-glucosidase were enhanced by HES as both molecules showed an increased transition midpoint (T(m)).	Hydroxyethyl Starch Derivatives	73-76	sucrase-isomaltase	Homo sapiens	38-55
22161170-13	2012	This finding could be explained by the reduction of glucose load in the jejunum produced by the alpha-glucosidase inhibition, which is the main stimulus for GLP-1 secretion.	Glucose	52-59	sucrase-isomaltase	Homo sapiens	96-113
22340932-12	2012	Combined patient and insurer spending for patients who were initiated on alpha-glucosidase inhibitors, thiazolidinediones, meglitinides, or dipeptidyl peptidase-4 inhibitors was $677 over a 6-month period compared with $116 and $118 for patients initiated on metformin or a sulfonylurea, respectively, a cost difference of approximately $1120 annually per patient.	Metformin	259-268	sucrase-isomaltase	Homo sapiens	73-90
24843559-5	2012	The meal tolerance test was performed with modified nutrient compositions, with or without pretreatment with the alpha-glucosidase inhibitor acarbose, or with substitution of sucrose with an equivalent dose of sweeteners in the meal.	Acarbose	141-149	sucrase-isomaltase	Homo sapiens	113-130
24843559-12	2012	In addition, inhibition of digestion of dietary carbohydrate by alpha-glucosidase inhibitors may prevent postprandial hyperglycemia by increasing GLP-1 secretion and by inhibiting glucose absorption.	Carbohydrates	48-60	sucrase-isomaltase	Homo sapiens	64-81
24843559-12	2012	In addition, inhibition of digestion of dietary carbohydrate by alpha-glucosidase inhibitors may prevent postprandial hyperglycemia by increasing GLP-1 secretion and by inhibiting glucose absorption.	Glucose	180-187	sucrase-isomaltase	Homo sapiens	64-81
22269981-1	2012	Ten new 1,2,3-triazole glycoconjugates were synthesized from d-glucose and evaluated in in vitro assays for their ability to inhibit the enzyme alpha-glucosidase.	Triazoles	8-22	sucrase-isomaltase	Homo sapiens	144-161
22269981-1	2012	Ten new 1,2,3-triazole glycoconjugates were synthesized from d-glucose and evaluated in in vitro assays for their ability to inhibit the enzyme alpha-glucosidase.	Glucose	61-70	sucrase-isomaltase	Homo sapiens	144-161
22340932-12	2012	Combined patient and insurer spending for patients who were initiated on alpha-glucosidase inhibitors, thiazolidinediones, meglitinides, or dipeptidyl peptidase-4 inhibitors was $677 over a 6-month period compared with $116 and $118 for patients initiated on metformin or a sulfonylurea, respectively, a cost difference of approximately $1120 annually per patient.	Sulfonylurea Compounds	274-286	sucrase-isomaltase	Homo sapiens	73-90
32218677-1	2012	Human intestinal maltase (HMA) is an alpha-glucosidase responsible for the hydrolysis of alpha-1,4-linkages from the non-reducing end of malto-oligosaccharides.	alpha-1,4-linkages	89-107	sucrase-isomaltase	Homo sapiens	37-54
22572506-1	2012	Glycogen storage disease type II (also called Pompe"s disease or acid maltase deficiency) is an autosomal recessive metabolic disorder which causes an accumulation of glycogen in the lysosomes due to deficiency of the lysosomal acid alpha-glucosidase enzyme.	Glycogen	167-175	sucrase-isomaltase	Homo sapiens	233-250
22290077-3	2012	Of the synthesized cyclitols, (+)-conduritol F potently inhibits type I alpha-glucosidase with an IC(50) value of 86.1 muM, which is five times greater than the standard antidiabetic drug, acarbose.	conduritol F	30-46	sucrase-isomaltase	Homo sapiens	72-89
22154663-2	2012	Inhibition of alpha-glucosidase with AR122 and AR125 is time dependent: with no preincubation, AR122 and AR125 are relatively moderate inhibitors, but interestingly, after a 120 min incubation, they were 50-fold more potent (AR122: IC(50)=2.47 muM and AR125: IC(50)=27.1 muM).	ar122	95-100	sucrase-isomaltase	Homo sapiens	14-31
22154663-2	2012	Inhibition of alpha-glucosidase with AR122 and AR125 is time dependent: with no preincubation, AR122 and AR125 are relatively moderate inhibitors, but interestingly, after a 120 min incubation, they were 50-fold more potent (AR122: IC(50)=2.47 muM and AR125: IC(50)=27.1 muM).	ar125	105-110	sucrase-isomaltase	Homo sapiens	14-31
22154663-0	2012	Virtual ligand screening of alpha-glucosidase: Identification of a novel potent noncarbohydrate mimetic inhibitor.	noncarbohydrate	80-95	sucrase-isomaltase	Homo sapiens	28-45
22154663-1	2012	5-Thiazoleacetamide derivatives of AR122 and AR125 were screened as alpha-glucosidase inhibitors by in silico high-throughput screening from commercial drug-like small compound libraries.	5-thiazoleacetamide	0-19	sucrase-isomaltase	Homo sapiens	68-85
22154663-2	2012	Inhibition of alpha-glucosidase with AR122 and AR125 is time dependent: with no preincubation, AR122 and AR125 are relatively moderate inhibitors, but interestingly, after a 120 min incubation, they were 50-fold more potent (AR122: IC(50)=2.47 muM and AR125: IC(50)=27.1 muM).	ar125	47-52	sucrase-isomaltase	Homo sapiens	14-31
22154663-2	2012	Inhibition of alpha-glucosidase with AR122 and AR125 is time dependent: with no preincubation, AR122 and AR125 are relatively moderate inhibitors, but interestingly, after a 120 min incubation, they were 50-fold more potent (AR122: IC(50)=2.47 muM and AR125: IC(50)=27.1 muM).	ar122	37-42	sucrase-isomaltase	Homo sapiens	14-31
22154663-2	2012	Inhibition of alpha-glucosidase with AR122 and AR125 is time dependent: with no preincubation, AR122 and AR125 are relatively moderate inhibitors, but interestingly, after a 120 min incubation, they were 50-fold more potent (AR122: IC(50)=2.47 muM and AR125: IC(50)=27.1 muM).	ar125	105-110	sucrase-isomaltase	Homo sapiens	14-31
32218677-1	2012	Human intestinal maltase (HMA) is an alpha-glucosidase responsible for the hydrolysis of alpha-1,4-linkages from the non-reducing end of malto-oligosaccharides.	maltooligosaccharides	137-159	sucrase-isomaltase	Homo sapiens	37-54
22301938-2	2012	The alpha-glucosidase inhibitor (alpha-GI) miglitol is useful for controlling the early postprandial increase of glucose, but the combined effect of miglitol and multiple daily insulin injections (MDI) on glucose excursion has not been evaluated.	Glucose	113-120	sucrase-isomaltase	Homo sapiens	4-21
22276251-6	2012	Metformin, alpha glucosidase inhibitors like acarbose, miglitol, and voglibose, and pioglitazone have all been used with success.	Acarbose	45-53	sucrase-isomaltase	Homo sapiens	11-28
23093911-1	2012	The alpha-glucosidase inhibitor acarbose has been used for more than 20 years in the management of hyperglycemia.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
22276251-6	2012	Metformin, alpha glucosidase inhibitors like acarbose, miglitol, and voglibose, and pioglitazone have all been used with success.	miglitol	55-63	sucrase-isomaltase	Homo sapiens	11-28
22276251-6	2012	Metformin, alpha glucosidase inhibitors like acarbose, miglitol, and voglibose, and pioglitazone have all been used with success.	voglibose	69-78	sucrase-isomaltase	Homo sapiens	11-28
22127878-0	2011	Probing the intestinal alpha-glucosidase enzyme specificities of starch-digesting maltase-glucoamylase and sucrase-isomaltase: synthesis and inhibitory properties of 3"- and 5"-maltose-extended de-O-sulfonated ponkoranol.	3"- and 5"-maltose	166-184	sucrase-isomaltase	Homo sapiens	23-40
23257526-4	2012	We experienced the case of an SPT1D patient with preserved endogenous insulin secretion and good glycemic control achieved with alpha-glucosidase inhibitor (alpha-GI) treatment alone for 10 years despite having continuously elevated GADA titers.	gada	233-237	sucrase-isomaltase	Homo sapiens	128-145
22187534-3	2012	In this type of DM, inhibition of alpha-glucosidase is a useful treatment to delay the absorption of glucose after meals.	Glucose	101-108	sucrase-isomaltase	Homo sapiens	34-51
22187534-5	2012	In this study, we determine the alpha-glucosidase inhibitory activity of 80% ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae.	Ethanol	77-84	sucrase-isomaltase	Homo sapiens	32-49
22989830-3	2012	She was subsequently treated successfully with miglitol, an alpha-glucosidase inhibitor (alpha-GI) taken twice a day; other alpha-GIs (acarbose and voglibose) were not effective.	miglitol	47-55	sucrase-isomaltase	Homo sapiens	60-77
23166747-1	2012	Fungal amylolytic enzymes, including alpha-amylase, gluocoamylase and alpha-glucosidase, have been extensively exploited in diverse industrial applications such as high fructose syrup production, paper making, food processing and ethanol production.	Fructose	169-177	sucrase-isomaltase	Homo sapiens	70-87
23166747-1	2012	Fungal amylolytic enzymes, including alpha-amylase, gluocoamylase and alpha-glucosidase, have been extensively exploited in diverse industrial applications such as high fructose syrup production, paper making, food processing and ethanol production.	Ethanol	230-237	sucrase-isomaltase	Homo sapiens	70-87
22563462-0	2012	Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal alpha-glucosidase subunit.	Starch	41-47	sucrase-isomaltase	Homo sapiens	103-120
22656375-5	2012	Genetic diseases linked to mutations in the disaccharidase genes (sucrase-isomaltase, lactase) and in sugar transporter genes (sodium/glucose cotransporter 1, glucose transporters 1 and 2) severely impact carbohydrate intake.	Carbohydrates	205-217	sucrase-isomaltase	Homo sapiens	66-84
22127878-0	2011	Probing the intestinal alpha-glucosidase enzyme specificities of starch-digesting maltase-glucoamylase and sucrase-isomaltase: synthesis and inhibitory properties of 3"- and 5"-maltose-extended de-O-sulfonated ponkoranol.	3"- and 5"-maltose	166-184	sucrase-isomaltase	Homo sapiens	107-125
22127878-0	2011	Probing the intestinal alpha-glucosidase enzyme specificities of starch-digesting maltase-glucoamylase and sucrase-isomaltase: synthesis and inhibitory properties of 3"- and 5"-maltose-extended de-O-sulfonated ponkoranol.	-o-sulfonated ponkoranol	196-220	sucrase-isomaltase	Homo sapiens	23-40
22127878-0	2011	Probing the intestinal alpha-glucosidase enzyme specificities of starch-digesting maltase-glucoamylase and sucrase-isomaltase: synthesis and inhibitory properties of 3"- and 5"-maltose-extended de-O-sulfonated ponkoranol.	-o-sulfonated ponkoranol	196-220	sucrase-isomaltase	Homo sapiens	107-125
21895422-4	2011	The phytic acid extract from raw samples revealed 59%-89% of DPPH radical scavenging capacity, 27-3,526 mmol Fe(II)/g extract of reducing power, 20%-72% of alpha-amylase inhibition activity and 8%-91% of alpha-glucosidase inhibition activity.	Phytic Acid	4-15	sucrase-isomaltase	Homo sapiens	204-221
21907768-1	2011	Intestinal alpha-glucosidase performs a physiologically vital function in the digestive process of dietary carbohydrates.	Carbohydrates	107-120	sucrase-isomaltase	Homo sapiens	11-28
21907768-2	2011	Administration of an alpha-glucosidase inhibitor may retard the digestion and absorption of carbohydrates.	Carbohydrates	92-105	sucrase-isomaltase	Homo sapiens	21-38
21946077-8	2011	XTPS showed significant higher inhibitory effects on alpha-glucosidase and alpha-amylase with inhibitory percentages of 64.35% and 82.24% than others TPS.	xanthosine 5'-triphosphate	0-4	sucrase-isomaltase	Homo sapiens	53-70
21284409-0	2011	Topological, hydrophobicity, and other descriptors on alpha-glucosidase inhibition: a QSAR study on xanthone derivatives.	xanthone	100-108	sucrase-isomaltase	Homo sapiens	54-71
21284409-1	2011	Quantitative structure activity relationship analysis was performed on a series of xanthone derivatives to establish the structural features required for alpha-glucosidase inhibitory activity.	xanthone	83-91	sucrase-isomaltase	Homo sapiens	154-171
21284409-5	2011	It describes that heteroatoms (oxygen atom connected with carbon atom) in the molecules are favourable for alpha-glucosidase inhibitory activity.	Oxygen	31-37	sucrase-isomaltase	Homo sapiens	107-124
21284409-5	2011	It describes that heteroatoms (oxygen atom connected with carbon atom) in the molecules are favourable for alpha-glucosidase inhibitory activity.	Carbon	58-64	sucrase-isomaltase	Homo sapiens	107-124
22313292-0	2011	Analysis of the alpha-glucosidase inhibitory activity of chromenone derivatives based on their molecular features: a computational study.	coumarin	57-67	sucrase-isomaltase	Homo sapiens	16-33
22313292-1	2011	alpha-Glucosidase is one of the important enzymes in glucose digestion and its inhibitors are known to possess a large number of therapeutic effects.	Glucose	53-60	sucrase-isomaltase	Homo sapiens	0-17
22313292-6	2011	Further, the study also reveals that the polarizability and hydrogen bond acceptor/donor groups are important for the alpha-glucosidase inhibitory activity and these results are in agreement with the earlier studies obtained in our laboratory on alpha-glucosidase inhibitors which have shows that the polar surface area of the molecule is important for the interaction.	Hydrogen	60-68	sucrase-isomaltase	Homo sapiens	118-135
22313292-6	2011	Further, the study also reveals that the polarizability and hydrogen bond acceptor/donor groups are important for the alpha-glucosidase inhibitory activity and these results are in agreement with the earlier studies obtained in our laboratory on alpha-glucosidase inhibitors which have shows that the polar surface area of the molecule is important for the interaction.	Hydrogen	60-68	sucrase-isomaltase	Homo sapiens	246-263
21417964-6	2011	In addition, the chemical modifications of ursolic acid to make more effective and water soluble derivatives, previous and current information regarding, its natural and semisynthetic analogs, focusing on its anticancer, cytotoxic, antitumor, antioxidant, anti-inflammatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, and hepatoprotective activities, briefly discussion is attempted here for its research perspectives.	ursolic acid	43-55	sucrase-isomaltase	Homo sapiens	308-325
21946084-9	2011	The inhibitor of MAPK signal pathway PD-98059 blocked the suppression of disaccharidase activities and expression of SI complex and Cdx2 mRNA induced by insulin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	37-45	sucrase-isomaltase	Homo sapiens	117-119
21895007-0	2011	Novel tripeptides with alpha-glucosidase inhibitory activity isolated from silk cocoon hydrolysate.	tripeptides	6-17	sucrase-isomaltase	Homo sapiens	23-40
21895007-5	2011	Moreover, the purified compounds were identified as Gly-Glu-Tyr (GEY, MW = 367 Da) and Gly-Tyr-Gly (GYG, MW = 295 Da) according to amino acid sequences, and their alpha-glucosidase inhibitory activities (IC(50)) were 2.7 and 1.5 mg/mL, respectively.	Gly-Glu-Tyr	52-63	sucrase-isomaltase	Homo sapiens	163-180
21895007-5	2011	Moreover, the purified compounds were identified as Gly-Glu-Tyr (GEY, MW = 367 Da) and Gly-Tyr-Gly (GYG, MW = 295 Da) according to amino acid sequences, and their alpha-glucosidase inhibitory activities (IC(50)) were 2.7 and 1.5 mg/mL, respectively.	glycyl-tyrosyl-glycine	87-98	sucrase-isomaltase	Homo sapiens	163-180
21924903-0	2011	Selectivity of 3"-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae.	3'-O-methylponkoranol	15-36	sucrase-isomaltase	Homo sapiens	98-116
21924903-1	2011	Human maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are two human intestinal glucosidases responsible for the final step of starch hydrolysis.	Starch	134-140	sucrase-isomaltase	Homo sapiens	38-56
21924903-1	2011	Human maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are two human intestinal glucosidases responsible for the final step of starch hydrolysis.	Starch	134-140	sucrase-isomaltase	Homo sapiens	58-60
21840710-0	2011	Synthesis and alpha-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.	valienamine pseudodisaccharides	58-89	sucrase-isomaltase	Homo sapiens	14-31
21840710-0	2011	Synthesis and alpha-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.	n-glycan	102-110	sucrase-isomaltase	Homo sapiens	14-31
21840710-2	2011	We synthesised valienamine analogues of the Glc(alpha1 3)Glc and Glc(alpha1 3)Man disaccharides representing the linkages cleaved by alpha-Glucosidase II in N-glycan biosynthesis.	valienamine	15-26	sucrase-isomaltase	Homo sapiens	133-150
21840710-2	2011	We synthesised valienamine analogues of the Glc(alpha1 3)Glc and Glc(alpha1 3)Man disaccharides representing the linkages cleaved by alpha-Glucosidase II in N-glycan biosynthesis.	glc(alpha1 3)glc	44-60	sucrase-isomaltase	Homo sapiens	133-150
21840710-2	2011	We synthesised valienamine analogues of the Glc(alpha1 3)Glc and Glc(alpha1 3)Man disaccharides representing the linkages cleaved by alpha-Glucosidase II in N-glycan biosynthesis.	n-glycan	157-165	sucrase-isomaltase	Homo sapiens	133-150
21840710-3	2011	These (N1 3)-linked pseudodisaccharides were found to have some alpha-Glucosidase II inhibitory activity, while two other (N1 6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme.	(n1 3)-linked pseudodisaccharides	6-39	sucrase-isomaltase	Homo sapiens	64-81
21813293-0	2011	The beneficial effect of alpha-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data.	Glucose	56-63	sucrase-isomaltase	Homo sapiens	25-42
21708415-0	2011	Toward potent alpha-glucosidase inhibitors based on xanthones: a closer look into the structure-activity correlations.	Xanthones	52-61	sucrase-isomaltase	Homo sapiens	14-31
21708415-1	2011	A series of novel xanthone derivatives 6-16 having non-coplanar and flexible structures were synthesized as potent alpha-glucosidase inhibitors.	xanthone	18-26	sucrase-isomaltase	Homo sapiens	115-132
21708415-3	2011	Among them, compounds 7-8, 10-12 and 15 were more active than 1-deoxynojirimycin, a well-known inhibitor for alpha-glucosidase.	1-DEOXYNOJIRIMYCIN	62-80	sucrase-isomaltase	Homo sapiens	109-126
21813293-0	2011	The beneficial effect of alpha-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data.	Metformin	170-179	sucrase-isomaltase	Homo sapiens	25-42
21555120-2	2011	This inhibitor exhibited strong anti-alpha-glucosidase activity with an IC50 value of 170.62nM and stimulated a dose-dependent increase in the uptake of a fluorescent d-glucose analog, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), in HepG2 cells at a rate higher than that of insulin controls.	2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose	185-249	sucrase-isomaltase	Homo sapiens	37-54
21240619-1	2011	We report a patient with neuropsychiatric systemic lupus erythematosus (NPSLE) complicated by diabetes mellitus (DM) who showed pneumatosis cystoides intestinalis (PCI) while being treated with prednisolone (PSL) and an alpha-glucosidase inhibitor (alphaGI).	Prednisolone	194-206	sucrase-isomaltase	Homo sapiens	220-237
21240619-1	2011	We report a patient with neuropsychiatric systemic lupus erythematosus (NPSLE) complicated by diabetes mellitus (DM) who showed pneumatosis cystoides intestinalis (PCI) while being treated with prednisolone (PSL) and an alpha-glucosidase inhibitor (alphaGI).	Prednisolone	73-76	sucrase-isomaltase	Homo sapiens	220-237
21555120-1	2011	A novel alpha-glucosidase inhibitor, vomifoliol 9-O-alpha-arabinofuranosyl (1 6)-beta-D-glucopyranoside, was isolated for the first time from leaves of Diospyros Kaki and its bioactivity analyzed.	vomifoliol 9-o-alpha-arabinofuranosyl (1 6)-beta-d-glucopyranoside	37-103	sucrase-isomaltase	Homo sapiens	8-25
21555120-2	2011	This inhibitor exhibited strong anti-alpha-glucosidase activity with an IC50 value of 170.62nM and stimulated a dose-dependent increase in the uptake of a fluorescent d-glucose analog, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), in HepG2 cells at a rate higher than that of insulin controls.	2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose	251-257	sucrase-isomaltase	Homo sapiens	37-54
21555120-2	2011	This inhibitor exhibited strong anti-alpha-glucosidase activity with an IC50 value of 170.62nM and stimulated a dose-dependent increase in the uptake of a fluorescent d-glucose analog, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), in HepG2 cells at a rate higher than that of insulin controls.	Glucose	167-176	sucrase-isomaltase	Homo sapiens	37-54
21711570-1	2011	BACKGROUND: alpha-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion.	Carbohydrates	108-120	sucrase-isomaltase	Homo sapiens	12-29
21631361-5	2011	Sugar loading tests with starch, maltose, and sucrose showed that MLE may reduce postprandial increases in blood glucose by acting as an intestinal alpha-glucosidase inhibitor.	Sugars	0-5	sucrase-isomaltase	Homo sapiens	148-165
21711570-1	2011	BACKGROUND: alpha-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion.	Glucose	202-209	sucrase-isomaltase	Homo sapiens	12-29
21711570-16	2011	CONCLUSIONS: The current study demonstrates one of the mechanisms in which cinnamon bark extract effectively inhibits alpha-glucosidase leading to suppression of postprandial hyperglycemia in STZ induced diabetic rats loaded with maltose, sucrose.	Sucrose	239-246	sucrase-isomaltase	Homo sapiens	118-135
21711570-15	2011	On the other hand, in rats that received glucose and cinnamon extract, postprandial hyperglycemia was not effectively suppressed, which indicates that the observed postprandial glycemic amelioration is majorly due to alpha-glucosidase inhibition.	Glucose	41-48	sucrase-isomaltase	Homo sapiens	217-234
21711570-16	2011	CONCLUSIONS: The current study demonstrates one of the mechanisms in which cinnamon bark extract effectively inhibits alpha-glucosidase leading to suppression of postprandial hyperglycemia in STZ induced diabetic rats loaded with maltose, sucrose.	Streptozocin	192-195	sucrase-isomaltase	Homo sapiens	118-135
21471980-2	2011	But mutant acid alpha-glucosidase (GAA) species responsive to imino sugars are limited.	Sugars	68-74	sucrase-isomaltase	Homo sapiens	16-33
21497424-0	2011	Inhibition of alpha-glucosidase and alpha-amylase by diaryl derivatives of imidazole-thione and 1,2,4-triazole-thiol.	imidazole-thione	75-91	sucrase-isomaltase	Homo sapiens	14-31
21497424-0	2011	Inhibition of alpha-glucosidase and alpha-amylase by diaryl derivatives of imidazole-thione and 1,2,4-triazole-thiol.	1,2,4-triazole-thiol	96-116	sucrase-isomaltase	Homo sapiens	14-31
21497424-3	2011	The in vitro treatment of the enzymes by 4,5-diphenylimidazole-2-thione exhibited a reversible inhibition of the non-competitive type with Ki value of 3.5 and 6.5x10(-5) M for alpha-glucosidase and alpha-amylase, respectively.	SCHEMBL9123425	41-71	sucrase-isomaltase	Homo sapiens	176-193
21497424-4	2011	4,5-diphenyl-1,2,4-triazole-3-thione showed a reversible inhibition of the competitive and non-competitive types, with Ki value of 10(-5) M magnitude, for alpha-glucosidase and alpha-amylase.	4,5-diphenyl-1,2,4-triazole-3-thione	0-36	sucrase-isomaltase	Homo sapiens	155-172
21497424-5	2011	On the other hand, 5-(o-hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thione did not display an inhibitory effect towards alpha-amylase but showed a potent inhibition of the competitive type for hepatic alpha-glucosidase with 10(-5) M magnitude of Ki value.	5-(o-hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thione	19-71	sucrase-isomaltase	Homo sapiens	198-215
21397496-1	2011	We constructed a library of sugar-dipeptide conjugate to find out the best complementary against hydrophobic pocket of alpha-glucosidase.	sugar-dipeptide	28-43	sucrase-isomaltase	Homo sapiens	119-136
21538147-0	2011	Inhibitory activity of cinnamon bark species and their combination effect with acarbose against intestinal alpha-glucosidase and pancreatic alpha-amylase.	Acarbose	79-87	sucrase-isomaltase	Homo sapiens	107-124
21538147-1	2011	Inhibition of alpha-glucosidase and pancreatic alpha-amylase is one of the therapeutic approaches for delaying carbohydrate digestion, resulting in reduced postprandial glucose.	Carbohydrates	111-123	sucrase-isomaltase	Homo sapiens	14-31
21538147-1	2011	Inhibition of alpha-glucosidase and pancreatic alpha-amylase is one of the therapeutic approaches for delaying carbohydrate digestion, resulting in reduced postprandial glucose.	Glucose	169-176	sucrase-isomaltase	Homo sapiens	14-31
21478015-0	2011	Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.	Thalidomide	119-130	sucrase-isomaltase	Homo sapiens	139-156
21320792-2	2011	We observed that hemoglobin in the enzyme reaction solution strongly interferes with the fluorescence of 4-methylumbelliferone released from 4-methylumbelliferyl alpha-D-glucopyranoside (4MU-alphaGlc) by acid alpha-glucosidase.	Hymecromone	105-126	sucrase-isomaltase	Homo sapiens	209-226
21320792-2	2011	We observed that hemoglobin in the enzyme reaction solution strongly interferes with the fluorescence of 4-methylumbelliferone released from 4-methylumbelliferyl alpha-D-glucopyranoside (4MU-alphaGlc) by acid alpha-glucosidase.	4-methylumbelliferyl glucoside	141-185	sucrase-isomaltase	Homo sapiens	209-226
21320792-2	2011	We observed that hemoglobin in the enzyme reaction solution strongly interferes with the fluorescence of 4-methylumbelliferone released from 4-methylumbelliferyl alpha-D-glucopyranoside (4MU-alphaGlc) by acid alpha-glucosidase.	4-methylumbelliferyl glucoside	187-199	sucrase-isomaltase	Homo sapiens	209-226
21478015-0	2011	Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.	phenethylphenylphthalimide	70-96	sucrase-isomaltase	Homo sapiens	139-156
21524914-5	2011	Furthermore, the addition of the metabolite analogs enhanced not only the rate constant but also the thermostability, salt tolerance, and substrate specificity of alpha-glucosidase simultaneously through the reduction of conformational perturbation of the enzyme.	Salts	118-122	sucrase-isomaltase	Homo sapiens	163-180
21397496-2	2011	The best substrate showed 150-fold improved K(m) value relative p-acetaminophenyl-alpha-D-glucopyranoside for alpha-glucosidase from Bacillus stearothermophillus.	p-acetaminophenyl-alpha-d-glucopyranoside	64-105	sucrase-isomaltase	Homo sapiens	110-127
21420866-0	2011	Role of the side chain stereochemistry in the alpha-glucosidase inhibitory activity of kotalanol, a potent natural alpha-glucosidase inhibitor.	Kotalanol	87-96	sucrase-isomaltase	Homo sapiens	46-63
21370820-1	2011	Carbohydrate digestion by alpha-glucosidase and subsequent glucose uptake at the brush border are critical for postprandial blood glucose control.	Carbohydrates	0-12	sucrase-isomaltase	Homo sapiens	26-43
21370820-1	2011	Carbohydrate digestion by alpha-glucosidase and subsequent glucose uptake at the brush border are critical for postprandial blood glucose control.	Blood Glucose	124-137	sucrase-isomaltase	Homo sapiens	26-43
21420866-0	2011	Role of the side chain stereochemistry in the alpha-glucosidase inhibitory activity of kotalanol, a potent natural alpha-glucosidase inhibitor.	Kotalanol	87-96	sucrase-isomaltase	Homo sapiens	115-132
21420866-1	2011	Synthesis and evaluation of four diastereomers (9a, 9b, 9c and 9d) of kotalanol, a potent alpha-glucosidase inhibitor isolated from an Ayurvedic medicinal plant Salacia species, are described.	Kotalanol	70-79	sucrase-isomaltase	Homo sapiens	90-107
21229140-1	2011	A two-component platinum(II) complex-polymer ensemble has been demonstrated for label-free spectroscopic detection of glucose and alpha-glucosidase activity, based on the electrostatic assembly of cationic platinum(II) complex molecules onto a glucose-bound anionic polymer.	platinum(ii)	16-28	sucrase-isomaltase	Homo sapiens	130-147
21355714-1	2011	BACKGROUND: The objective of this study was to evaluate the effects of the alpha-glucosidase inhibitor acarbose on glucose fluctuations in patients with type 2 diabetes using continuous glucose monitoring (CGM).	Acarbose	103-111	sucrase-isomaltase	Homo sapiens	75-92
21355714-1	2011	BACKGROUND: The objective of this study was to evaluate the effects of the alpha-glucosidase inhibitor acarbose on glucose fluctuations in patients with type 2 diabetes using continuous glucose monitoring (CGM).	Glucose	115-122	sucrase-isomaltase	Homo sapiens	75-92
21612064-6	2011	Likewise, a group of intestinal alpha-glucosidase inhibitors--acarbose in this country--was introduced into clinical practice some years ago.	Acarbose	62-70	sucrase-isomaltase	Homo sapiens	32-49
21291335-1	2011	BACKGROUND: This study aimed to compare glucose variability in patients given the alpha-glucosidase inhibitors miglitol and acarbose using continuous glucose monitoring (CGM).	Glucose	40-47	sucrase-isomaltase	Homo sapiens	82-99
21229140-1	2011	A two-component platinum(II) complex-polymer ensemble has been demonstrated for label-free spectroscopic detection of glucose and alpha-glucosidase activity, based on the electrostatic assembly of cationic platinum(II) complex molecules onto a glucose-bound anionic polymer.	Polymers	37-44	sucrase-isomaltase	Homo sapiens	130-147
21229140-1	2011	A two-component platinum(II) complex-polymer ensemble has been demonstrated for label-free spectroscopic detection of glucose and alpha-glucosidase activity, based on the electrostatic assembly of cationic platinum(II) complex molecules onto a glucose-bound anionic polymer.	platinum(ii)	206-218	sucrase-isomaltase	Homo sapiens	130-147
21229140-1	2011	A two-component platinum(II) complex-polymer ensemble has been demonstrated for label-free spectroscopic detection of glucose and alpha-glucosidase activity, based on the electrostatic assembly of cationic platinum(II) complex molecules onto a glucose-bound anionic polymer.	Glucose	244-251	sucrase-isomaltase	Homo sapiens	130-147
21229140-1	2011	A two-component platinum(II) complex-polymer ensemble has been demonstrated for label-free spectroscopic detection of glucose and alpha-glucosidase activity, based on the electrostatic assembly of cationic platinum(II) complex molecules onto a glucose-bound anionic polymer.	Polymers	266-273	sucrase-isomaltase	Homo sapiens	130-147
21290422-0	2011	Evaluation of polyhydroxybenzophenones as alpha-glucosidase inhibitors.	polyhydroxybenzophenones	14-38	sucrase-isomaltase	Homo sapiens	42-59
21290422-1	2011	This experiment was designed to synthesize 18 kinds of polyhydroxybenzophenones by using Friedel-Crafts reaction, and to measure the inhibitory activity on alpha-glucosidase with p-nitrophenyl-beta-D-galactopyranoside (PNPG) as a substrate.	polyhydroxybenzophenones	55-79	sucrase-isomaltase	Homo sapiens	156-173
21290422-1	2011	This experiment was designed to synthesize 18 kinds of polyhydroxybenzophenones by using Friedel-Crafts reaction, and to measure the inhibitory activity on alpha-glucosidase with p-nitrophenyl-beta-D-galactopyranoside (PNPG) as a substrate.	friedel	89-96	sucrase-isomaltase	Homo sapiens	156-173
21290422-1	2011	This experiment was designed to synthesize 18 kinds of polyhydroxybenzophenones by using Friedel-Crafts reaction, and to measure the inhibitory activity on alpha-glucosidase with p-nitrophenyl-beta-D-galactopyranoside (PNPG) as a substrate.	4-nitrophenylgalactoside	179-217	sucrase-isomaltase	Homo sapiens	156-173
21290422-1	2011	This experiment was designed to synthesize 18 kinds of polyhydroxybenzophenones by using Friedel-Crafts reaction, and to measure the inhibitory activity on alpha-glucosidase with p-nitrophenyl-beta-D-galactopyranoside (PNPG) as a substrate.	4-nitrophenylgalactoside	219-223	sucrase-isomaltase	Homo sapiens	156-173
21290422-4	2011	Among all these compounds, 2,4,4",6-butahydroxydiphenylketone (11) was found to be the most potent alpha-glucosidase inhibitor with an IC(50) value of 10.62 micromol L(-1) .	2,4,4",6-butahydroxydiphenylketone	27-61	sucrase-isomaltase	Homo sapiens	99-116
21325768-4	2011	An alpha-glucosidase inhibitor in combination with frequent small meals reduced the postprandial hyperglycemia (glucose spike) and ameliorated the reactive hypoglycemia.	Glucose	112-119	sucrase-isomaltase	Homo sapiens	3-20
21171896-0	2011	Prediction of the relationship between the structural features of andrographolide derivatives and alpha-glucosidase inhibitory activity: a quantitative structure-activity relationship (QSAR) study.	andrographolide	66-81	sucrase-isomaltase	Homo sapiens	98-115
21171896-1	2011	In order to predict the structural features responsible for alpha-glucosidase inhibitory activity, a quantitative structure-activity relationship (QSAR) analysis was performed on a series of andrographolide derivatives.	andrographolide	191-206	sucrase-isomaltase	Homo sapiens	60-77
21804254-0	2011	Synthesis of new alpha-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides.	Oleanolic Acid	55-69	sucrase-isomaltase	Homo sapiens	17-34
21804254-0	2011	Synthesis of new alpha-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides.	cinnamic	84-92	sucrase-isomaltase	Homo sapiens	17-34
21804254-0	2011	Synthesis of new alpha-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides.	Amides	93-99	sucrase-isomaltase	Homo sapiens	17-34
21804254-1	2011	A series of alpha-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized.	Oleanolic Acid	50-64	sucrase-isomaltase	Homo sapiens	12-29
21804254-1	2011	A series of alpha-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized.	cinnamamide	84-98	sucrase-isomaltase	Homo sapiens	12-29
21804254-3	2011	In general, the compounds with 3,28-disubstituted oleanolic acid exhibited stronger activity than those 28-monosubstituted analogues, and variation of cinnamic amide substitution significantly affected alpha-glucosidase inhibition activities.	3,28-disubstituted oleanolic acid	31-64	sucrase-isomaltase	Homo sapiens	202-219
21804254-3	2011	In general, the compounds with 3,28-disubstituted oleanolic acid exhibited stronger activity than those 28-monosubstituted analogues, and variation of cinnamic amide substitution significantly affected alpha-glucosidase inhibition activities.	Amides	160-165	sucrase-isomaltase	Homo sapiens	202-219
21804254-4	2011	Most of the compounds showed potent inhibitory activity against alpha-glucosidase with much greater efficacy than a typical alpha-glucosidase inhibitor, acarbose.	Acarbose	153-161	sucrase-isomaltase	Homo sapiens	64-81
21804254-4	2011	Most of the compounds showed potent inhibitory activity against alpha-glucosidase with much greater efficacy than a typical alpha-glucosidase inhibitor, acarbose.	Acarbose	153-161	sucrase-isomaltase	Homo sapiens	124-141
21425674-1	2011	Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies.	Quercetin	0-9	sucrase-isomaltase	Homo sapiens	159-176
21425674-1	2011	Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies.	kaempferol	11-21	sucrase-isomaltase	Homo sapiens	159-176
21425674-1	2011	Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies.	Rutin	45-50	sucrase-isomaltase	Homo sapiens	159-176
21185187-0	2011	The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of alpha-glucosidase inhibitors.	1-c-alkyl-l-arabinoiminofuranoses	43-76	sucrase-isomaltase	Homo sapiens	95-112
22096315-2	2011	One of the effective managements of diabetes mellitus, in particular, non-insulin-dependent diabetes mellitus (NIDDM) to decrease postprandial hyperglycemia, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as alpha-glucosidase and alpha-amylase, in the digestive organs.	Glucose	189-196	sucrase-isomaltase	Homo sapiens	256-273
20981499-0	2011	Quantitative analysis of neosalacinol and neokotalanol, another two potent alpha-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography.	Neokotalanol	42-54	sucrase-isomaltase	Homo sapiens	75-92
22096315-2	2011	One of the effective managements of diabetes mellitus, in particular, non-insulin-dependent diabetes mellitus (NIDDM) to decrease postprandial hyperglycemia, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as alpha-glucosidase and alpha-amylase, in the digestive organs.	Carbohydrates	214-226	sucrase-isomaltase	Homo sapiens	256-273
22096315-3	2011	alpha-Glucosidase is the key enzyme catalyzing the final step in the digestive process of carbohydrates.	Carbohydrates	90-103	sucrase-isomaltase	Homo sapiens	0-17
22096315-4	2011	Hence, alpha-glucosidase inhibitors can retard the liberation of d-glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postprandial hyperglycemia.	Glucose	65-74	sucrase-isomaltase	Homo sapiens	7-24
22096315-4	2011	Hence, alpha-glucosidase inhibitors can retard the liberation of d-glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postprandial hyperglycemia.	Carbohydrates	96-109	sucrase-isomaltase	Homo sapiens	7-24
22096315-4	2011	Hence, alpha-glucosidase inhibitors can retard the liberation of d-glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postprandial hyperglycemia.	Glucose	67-74	sucrase-isomaltase	Homo sapiens	7-24
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Flavonoids	70-80	sucrase-isomaltase	Homo sapiens	5-22
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Alkaloids	82-91	sucrase-isomaltase	Homo sapiens	5-22
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Terpenes	93-103	sucrase-isomaltase	Homo sapiens	5-22
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Anthocyanins	104-116	sucrase-isomaltase	Homo sapiens	5-22
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Glycosides	118-128	sucrase-isomaltase	Homo sapiens	5-22
20547473-0	2010	Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with alpha-glucosidase inhibitor.	Pioglitazone	10-22	sucrase-isomaltase	Homo sapiens	93-110
21090700-0	2010	Duboscic acid: a potent alpha-glucosidase inhibitor with an unprecedented triterpenoidal carbon skeleton from Duboscia macrocarpa.	duboscic acid	0-13	sucrase-isomaltase	Homo sapiens	24-41
21090700-3	2010	Duboscic acid has a potent alpha-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.	duboscic acid	0-13	sucrase-isomaltase	Homo sapiens	27-44
20667563-0	2010	The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus.	Glucose	51-58	sucrase-isomaltase	Homo sapiens	4-21
21053896-0	2010	Hydroxycoumarin derivatives: novel and potent alpha-glucosidase inhibitors.	3-hydroxycoumarin	0-15	sucrase-isomaltase	Homo sapiens	46-63
21053896-1	2010	A novel class of hydroxycoumarin derivatives were found to be potent alpha-glucosidase inhibitors.	3-hydroxycoumarin	17-32	sucrase-isomaltase	Homo sapiens	69-86
21053896-4	2010	Among all hydroxycoumarin derivatives studied, compounds 10 and 11 exhibited the highest activities, were specific inhibitors of alpha-glucosidase, and could be exploited as the lead compounds for the development of potent alpha-glucosidase inhibitors.	3-hydroxycoumarin	10-25	sucrase-isomaltase	Homo sapiens	129-146
21053896-4	2010	Among all hydroxycoumarin derivatives studied, compounds 10 and 11 exhibited the highest activities, were specific inhibitors of alpha-glucosidase, and could be exploited as the lead compounds for the development of potent alpha-glucosidase inhibitors.	3-hydroxycoumarin	10-25	sucrase-isomaltase	Homo sapiens	223-240
20841351-0	2010	Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation.	o-glycan	6-14	sucrase-isomaltase	Homo sapiens	73-91
20685216-0	2010	Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones.	tibolone	73-81	sucrase-isomaltase	Homo sapiens	0-17
20685216-0	2010	Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones.	hydroxytibolones	86-102	sucrase-isomaltase	Homo sapiens	0-17
20685216-4	2010	Metabolites of tibolone (1) exhibited significant inhibitory activities against alpha-glucosidase and tyrosinase enzymes.	tibolone	15-23	sucrase-isomaltase	Homo sapiens	80-97
20964285-1	2010	The asymmetric total synthesis of the alpha-glucosidase inhibitor (+)-castanospermine is reported.	castanospermine	66-85	sucrase-isomaltase	Homo sapiens	38-55
20713144-7	2010	The alpha-glucosidase inhibitory activity of ASE was approximately 1/13 of that of acarbose.	Acarbose	83-91	sucrase-isomaltase	Homo sapiens	4-21
21061220-0	2010	Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and alpha-glucosidase inhibitors.	benzyl-substituted flavones	45-72	sucrase-isomaltase	Homo sapiens	111-128
21061220-2	2010	In the present investigation, a series of benzyl substituted-flavone derivatives have been synthesized from the lead compounds and were screened against 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and alpha-glucosidase inhibitory properties.	benzyl substituted-flavone	42-68	sucrase-isomaltase	Homo sapiens	218-235
20883057-1	2010	Alogliptin (Nesina ) is a dipeptidyl peptidase-4 inhibitor that is approved in Japan for the treatment of adult patients with type 2 diabetes mellitus that is inadequately controlled by diet and exercise alone or by diet plus treatment with an alpha-glucosidase inhibitor.	alogliptin	0-10	sucrase-isomaltase	Homo sapiens	244-261
20883057-1	2010	Alogliptin (Nesina ) is a dipeptidyl peptidase-4 inhibitor that is approved in Japan for the treatment of adult patients with type 2 diabetes mellitus that is inadequately controlled by diet and exercise alone or by diet plus treatment with an alpha-glucosidase inhibitor.	alogliptin	12-18	sucrase-isomaltase	Homo sapiens	244-261
20957102-0	2010	Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal alpha-glucosidase and pancreatic alpha-amylase.	cyanidin	25-33	sucrase-isomaltase	Homo sapiens	109-126
20827790-0	2010	A novel competitive class of alpha-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives.	(e)-1-phenyl-3-(4-styrylphenyl)urea	59-94	sucrase-isomaltase	Homo sapiens	29-46
20827790-2	2010	Here, we show that readily accessible achiral (E)-1-phenyl-3-(4-strylphenyl)ureas are potent competitive alpha-glucosidase inhibitors.	(e)-1-phenyl-3-(4-strylphenyl)ureas	46-81	sucrase-isomaltase	Homo sapiens	105-122
20925095-1	2010	Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an alpha-glucosidase is altered into an excellent, competitive inhibitor for a beta-galactosidase.	lactame	40-47	sucrase-isomaltase	Homo sapiens	227-244
20925095-1	2010	Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an alpha-glucosidase is altered into an excellent, competitive inhibitor for a beta-galactosidase.	Amines	70-75	sucrase-isomaltase	Homo sapiens	227-244
20925095-1	2010	Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an alpha-glucosidase is altered into an excellent, competitive inhibitor for a beta-galactosidase.	trihydroxy-2-thiaquinolizidine	100-130	sucrase-isomaltase	Homo sapiens	227-244
20924896-0	2010	New triterpenes from Salacia hainanensis Chun et How with alpha-glucosidase inhibitory activity.	Triterpenes	4-15	sucrase-isomaltase	Homo sapiens	58-75
20924896-3	2010	All of them showed a much stronger inhibiting activity on alpha-glucosidase than the positive control (acarbose, IC50 = 5.83 muM).	Acarbose	103-111	sucrase-isomaltase	Homo sapiens	58-75
20153003-2	2010	Miglitol treatment may lead to increased alpha-glucosidase activities toward the ileum because carbohydrate flow toward the ileum increases.	Carbohydrates	95-107	sucrase-isomaltase	Homo sapiens	41-58
20153003-7	2010	These results suggest that the delay in carbohydrate digestion and absorption along the jejunal-ileal axis by miglitol supplementation in rats is associated with increased alpha-glucosidase activities toward the ileum.	Carbohydrates	40-52	sucrase-isomaltase	Homo sapiens	172-189
20801033-0	2010	Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring alpha-glucosidase inhibitor.	ponkoranol	154-164	sucrase-isomaltase	Homo sapiens	188-205
20581222-6	2010	The alpha-glucosidase, a member of GH31 family, shows substrate preference for alpha(1-6) over alpha(1-4) glycosidic linkages and produces glucose from isomaltose as well as maltose.	Glucose	139-146	sucrase-isomaltase	Homo sapiens	4-21
20581222-6	2010	The alpha-glucosidase, a member of GH31 family, shows substrate preference for alpha(1-6) over alpha(1-4) glycosidic linkages and produces glucose from isomaltose as well as maltose.	Maltose	155-162	sucrase-isomaltase	Homo sapiens	4-21
20626248-4	2010	CP-SAB had alpha-glucosidase inhibitory activity that increased with increased dose (1-5 mg/mL) from 60% to 100% inhibition.	cp-sab	0-6	sucrase-isomaltase	Homo sapiens	11-28
20153003-2	2010	Miglitol treatment may lead to increased alpha-glucosidase activities toward the ileum because carbohydrate flow toward the ileum increases.	miglitol	0-8	sucrase-isomaltase	Homo sapiens	41-58
20957102-0	2010	Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal alpha-glucosidase and pancreatic alpha-amylase.	Acarbose	81-89	sucrase-isomaltase	Homo sapiens	109-126
20356844-1	2010	Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are small intestinal enzymes that work concurrently to hydrolyze the mixture of linear alpha-1,4- and branched alpha-1,6-oligosaccharide substrates that typically make up terminal starch digestion products.	alpha-1,6-oligosaccharide	173-198	sucrase-isomaltase	Homo sapiens	38-56
20695638-3	2010	In control samples, maltose and maltotriose were hydrolyzed by alpha-glucosidase and not beta-galactosidase, whereas lactose was resistant to alpha-glucosidase but was hydrolyzed with beta-galactosidase.	Maltose	20-27	sucrase-isomaltase	Homo sapiens	63-80
20695638-3	2010	In control samples, maltose and maltotriose were hydrolyzed by alpha-glucosidase and not beta-galactosidase, whereas lactose was resistant to alpha-glucosidase but was hydrolyzed with beta-galactosidase.	maltotriose	32-43	sucrase-isomaltase	Homo sapiens	63-80
20695638-3	2010	In control samples, maltose and maltotriose were hydrolyzed by alpha-glucosidase and not beta-galactosidase, whereas lactose was resistant to alpha-glucosidase but was hydrolyzed with beta-galactosidase.	Lactose	117-124	sucrase-isomaltase	Homo sapiens	142-159
20698522-3	2010	GlvA (6-phospho-alpha-glucosidase) is a glycosidase belonging to family GH4 and follows a regioselective redox-neutral mechanism of glycosidic-bond hydrolysis that favors alpha- over beta-glycosides.	GH4	72-75	sucrase-isomaltase	Homo sapiens	16-33
20698522-3	2010	GlvA (6-phospho-alpha-glucosidase) is a glycosidase belonging to family GH4 and follows a regioselective redox-neutral mechanism of glycosidic-bond hydrolysis that favors alpha- over beta-glycosides.	beta-glycosides	183-198	sucrase-isomaltase	Homo sapiens	16-33
20667739-0	2010	New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase.	n-(phenoxydecyl)phthalimide	4-31	sucrase-isomaltase	Homo sapiens	90-107
20667739-1	2010	Several members of a new family of non-sugar-type alpha-glucosidase inhibitors, bearing a phthalimide moiety connected to a variously substituted phenoxy ring by an alkyl chain, were synthesized and their activities were investigated.	phthalimide	90-101	sucrase-isomaltase	Homo sapiens	50-67
20552113-0	2010	Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.	n-, s-, and c-glycoside castanospermine	13-52	sucrase-isomaltase	Homo sapiens	86-103
20838571-1	2010	Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase.	1-DEOXYNOJIRIMYCIN	28-46	sucrase-isomaltase	Homo sapiens	70-87
20838571-1	2010	Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase.	1-DEOXYNOJIRIMYCIN	48-51	sucrase-isomaltase	Homo sapiens	70-87
20080449-0	2010	Maltose biosensing based on co-immobilization of alpha-glucosidase and pyranose oxidase.	Maltose	0-7	sucrase-isomaltase	Homo sapiens	49-66
20080449-1	2010	A new bi-enzymatic system was designed by co-immobilization of alpha-glucosidase (AG) and pyranose oxidase (PyOx) for maltose analysis.	Maltose	118-125	sucrase-isomaltase	Homo sapiens	63-80
20080449-1	2010	A new bi-enzymatic system was designed by co-immobilization of alpha-glucosidase (AG) and pyranose oxidase (PyOx) for maltose analysis.	Maltose	118-125	sucrase-isomaltase	Homo sapiens	82-84
20931877-1	2010	OBJECTIVE: Targeted at the important enzyme in human glucose metabolic pathway, the purpose of this paper is to establish alpha-glucosidase inhibitors high throughput screening model.	Glucose	53-60	sucrase-isomaltase	Homo sapiens	122-139
20734944-0	2010	The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor.	aspergillusol A	29-44	sucrase-isomaltase	Homo sapiens	49-66
20734944-1	2010	The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor, was accomplished in an overall high yielding reaction sequence.	aspergillusol A	29-44	sucrase-isomaltase	Homo sapiens	49-66
20356844-1	2010	Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are small intestinal enzymes that work concurrently to hydrolyze the mixture of linear alpha-1,4- and branched alpha-1,6-oligosaccharide substrates that typically make up terminal starch digestion products.	Starch	242-248	sucrase-isomaltase	Homo sapiens	38-56
20404854-12	2010	Agents that decrease intestinal carbohydrate digestion (alpha-glucosidase inhibitors) or decrease insulin resistance (metformin) might be alternative adjunctive therapies in T1DM, though its benefits are marginally supported by clinical data.	Carbohydrates	32-44	sucrase-isomaltase	Homo sapiens	56-73
19834782-0	2010	An alpha-glucosidase inhibitor, acarbose treatment decreases serum levels of glyceraldehyde-derived advanced glycation end products (AGEs) in patients with type 2 diabetes.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	3-20
19834782-0	2010	An alpha-glucosidase inhibitor, acarbose treatment decreases serum levels of glyceraldehyde-derived advanced glycation end products (AGEs) in patients with type 2 diabetes.	Glyceraldehyde	77-91	sucrase-isomaltase	Homo sapiens	3-20
20815224-2	2010	Along with the application of acarbose which is a kind of alpha-glucosidase inhibitor, many research groups pay attention to the crude alpha-glucosidase inhibitor screened from the medicinal herbs in order to find new, safe, and effective medicine.	Acarbose	30-38	sucrase-isomaltase	Homo sapiens	58-75
20307255-5	2010	Thalidomide analogues have been used as inhibitors of alpha glucosidase and could be potential drugs for diabetes treatment.	Thalidomide	0-11	sucrase-isomaltase	Homo sapiens	54-71
20815224-2	2010	Along with the application of acarbose which is a kind of alpha-glucosidase inhibitor, many research groups pay attention to the crude alpha-glucosidase inhibitor screened from the medicinal herbs in order to find new, safe, and effective medicine.	Acarbose	30-38	sucrase-isomaltase	Homo sapiens	135-152
20388897-12	2010	Although use of thiazolidinediones, sulfonylureas, and glinides were associated with weight gain (range, 1.77-2.08 kg), glucagon-like peptide-1 analogs, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors were associated with weight loss or no weight change.	Sulfonylurea Compounds	36-49	sucrase-isomaltase	Homo sapiens	153-170
21437083-10	2010	The alpha-glucosidase inhibitor acarbose, and the alpha-amylase inhibitor phaseolamine, have been used in humans with some promising results relating to weight loss.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
20388897-12	2010	Although use of thiazolidinediones, sulfonylureas, and glinides were associated with weight gain (range, 1.77-2.08 kg), glucagon-like peptide-1 analogs, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors were associated with weight loss or no weight change.	glinides	55-63	sucrase-isomaltase	Homo sapiens	153-170
20223998-1	2010	Pompe disease, a deficiency of lysosomal acid alpha-glucosidase, is a disorder of glycogen metabolism that can affect infants, children, or adults.	Glycogen	82-90	sucrase-isomaltase	Homo sapiens	46-63
20133952-1	2010	In the intestinal epithelium, the Cdx, GATA, and HNF transcription factor families are responsible for the expression of differentiation markers such as sucrase-isomaltase.	Cefadroxil	34-37	sucrase-isomaltase	Homo sapiens	153-171
20479989-0	2010	QSAR Studies on andrographolide derivatives as alpha-glucosidase inhibitors.	andrographolide	16-31	sucrase-isomaltase	Homo sapiens	47-64
20470247-1	2010	The inhibition of alpha-glucosidase and alpha-amylase, enzymes involved in the digestion of carbohydrates, can significantly reduce the post-prandial increase of blood glucose and therefore can be an important strategy in the management of blood glucose level in type 2 diabetic and borderline patients.	Carbohydrates	92-105	sucrase-isomaltase	Homo sapiens	18-35
20470247-1	2010	The inhibition of alpha-glucosidase and alpha-amylase, enzymes involved in the digestion of carbohydrates, can significantly reduce the post-prandial increase of blood glucose and therefore can be an important strategy in the management of blood glucose level in type 2 diabetic and borderline patients.	Glucose	168-175	sucrase-isomaltase	Homo sapiens	18-35
19418260-0	2010	Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction.	Urea	33-37	sucrase-isomaltase	Homo sapiens	0-17
19418260-1	2010	In this study, we investigated structural changes in alpha-glucosidase during urea denaturation.	Urea	78-82	sucrase-isomaltase	Homo sapiens	53-70
19418260-2	2010	Alpha-glucosidase was inactivated by urea in a dose-dependent manner.	Urea	37-41	sucrase-isomaltase	Homo sapiens	0-17
19418260-4	2010	Urea inhibited alpha-glucosidase in a mixed-type reaction.	Urea	0-4	sucrase-isomaltase	Homo sapiens	15-32
19418260-6	2010	We also simulated the docking between alpha-glucosidase and urea.	Urea	60-64	sucrase-isomaltase	Homo sapiens	38-55
20479989-1	2010	Andrographolide derivatives were shown to inhibit alpha-glucosidase.	andrographolide	0-15	sucrase-isomaltase	Homo sapiens	50-67
20479989-4	2010	The obtained results suggested that proposed combination of 2D and 3D QSAR models could be useful in predicting the alpha-glucosidase inhibiting activity of andrographolide derivatives.	andrographolide	157-172	sucrase-isomaltase	Homo sapiens	116-133
20307399-8	2010	RESULTS: Alpha-glucosidase inhibitors (1.25), metformin (2.20), and thiazolidinediones (TZDs; 1.25-1.32) demonstrate a greater effect on glucose supply (SD ratio &gt;1), while secretagogues (0.69-0.81), basal insulins (0.77-0.79), and bolus insulins (0.62-0.67) demonstrate a greater effect on insulin demand (SD ratio &lt;1).	Thiazolidinediones	88-92	sucrase-isomaltase	Homo sapiens	9-26
20045223-0	2010	Synthesis and evaluation of the alpha-glucosidase inhibitory activity of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives.	3-[4-(phenylsulfonamido)benzoyl]-2h-1-benzopyran-2-one	73-127	sucrase-isomaltase	Homo sapiens	32-49
20045223-1	2010	In the course of studies directed toward the discovery of novel non-sugar alpha-glucosidase inhibitors for the treatment of diabetes, a series of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives was synthesized and evaluated as alpha-glucosidase inhibitors.	3-[4-(phenylsulfonamido)benzoyl]-2h-1-benzopyran-2-one	146-200	sucrase-isomaltase	Homo sapiens	74-91
20045223-1	2010	In the course of studies directed toward the discovery of novel non-sugar alpha-glucosidase inhibitors for the treatment of diabetes, a series of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives was synthesized and evaluated as alpha-glucosidase inhibitors.	3-[4-(phenylsulfonamido)benzoyl]-2h-1-benzopyran-2-one	146-200	sucrase-isomaltase	Homo sapiens	246-263
20307399-8	2010	RESULTS: Alpha-glucosidase inhibitors (1.25), metformin (2.20), and thiazolidinediones (TZDs; 1.25-1.32) demonstrate a greater effect on glucose supply (SD ratio &gt;1), while secretagogues (0.69-0.81), basal insulins (0.77-0.79), and bolus insulins (0.62-0.67) demonstrate a greater effect on insulin demand (SD ratio &lt;1).	Glucose	137-144	sucrase-isomaltase	Homo sapiens	9-26
20307399-9	2010	CONCLUSION: Alpha-glucosidase inhibitors, metformin, and TZDs demonstrate a greater effect on glucose supply, while secretagogues, basal insulin, and bolus insulin demonstrate a greater effect on insulin demand.	Glucose	94-101	sucrase-isomaltase	Homo sapiens	12-29
19505462-0	2009	Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?	Hydrogen	103-111	sucrase-isomaltase	Homo sapiens	19-36
20686288-0	2010	Pneumatosis cystoides intestinalis induced by the alpha-glucosidase inhibitor miglitol.	miglitol	78-86	sucrase-isomaltase	Homo sapiens	50-67
19405040-4	2009	Glucaffect provides potent alpha-glucosidase inhibitors of herbal source such Pycnogenol, Madeglucyl and various others which obstruct absorption of carbohydrates, such as starch.	pycnogenols	78-88	sucrase-isomaltase	Homo sapiens	27-44
19405040-4	2009	Glucaffect provides potent alpha-glucosidase inhibitors of herbal source such Pycnogenol, Madeglucyl and various others which obstruct absorption of carbohydrates, such as starch.	Carbohydrates	149-162	sucrase-isomaltase	Homo sapiens	27-44
19405040-4	2009	Glucaffect provides potent alpha-glucosidase inhibitors of herbal source such Pycnogenol, Madeglucyl and various others which obstruct absorption of carbohydrates, such as starch.	Starch	172-178	sucrase-isomaltase	Homo sapiens	27-44
19918292-4	2009	This is the first report of pneumatosis cystoides intestinalis after 12 years of treatment with the alpha-glucosidase inhibitor acarbose.	Acarbose	128-136	sucrase-isomaltase	Homo sapiens	100-117
19918292-6	2009	She had been treated for type 2 diabetes mellitus with an alpha-glucosidase inhibitor (acarbose, 150 mg daily) for 12 years.	Acarbose	87-95	sucrase-isomaltase	Homo sapiens	58-75
19443236-0	2009	Screening and structural characterization of alpha-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MS(n) and SORI-CID FTICR MS.	Flavonoids	93-103	sucrase-isomaltase	Homo sapiens	45-62
19443236-3	2009	Several other C-glycosylflavones (vitexin, isovitexin, orientin, isooriention) and their aglycones apigenin and luteolin were evaluated by in vitro assays, and were found to possess strong alpha-glucosidase inhibitory activities as well.	c-glycosylflavones	14-32	sucrase-isomaltase	Homo sapiens	189-206
19443236-5	2009	C-3"-OH of the B-ring of flavones in particular increased the alpha-glucosidase inhibition activity, whereas C-glycosylations at C-6 or C-8 of the A ring weakened the inhibition activity.	Flavones	25-33	sucrase-isomaltase	Homo sapiens	62-79
19539483-0	2009	Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.	phenethylphenyl phthalimide	91-118	sucrase-isomaltase	Homo sapiens	14-31
19539483-4	2009	In the present work, structural development studies of phenethylphenyl phthalimide 9, which possesses LXRalpha/beta dual-antagonistic activity and alpha-glucosidase-inhibitory activity, led to the LXRalpha-selective antagonist 23f.	phenethylphenyl phthalimide 9	55-84	sucrase-isomaltase	Homo sapiens	147-164
20087993-0	2010	Chiral piperazine-2,5-dione derivatives as effective alpha-glucosidase inhibitors.	2,5-dioxopiperazine	7-27	sucrase-isomaltase	Homo sapiens	53-70
20390739-0	2010	Synthesis and alpha-glucosidase inhibitory activity of oleanolic acid derivatives.	Oleanolic Acid	55-69	sucrase-isomaltase	Homo sapiens	14-31
18768334-5	2009	In general, alpha-glucosidase inhibitors delay carbohydrate absorption, metiglinides and sulfonylureas increase insulin supply, and biguanides and thiazolidinediones enhance insulin action.	Carbohydrates	47-59	sucrase-isomaltase	Homo sapiens	12-29
19772492-0	2009	A series of cinnamic acid derivatives and their inhibitory activity on intestinal alpha-glucosidase.	cinnamic acid	12-25	sucrase-isomaltase	Homo sapiens	82-99
19772492-1	2009	Inhibition of alpha-glucosidase and alpha-amylase delays the digestion of starch and disaccharides to absorbable monosaccharides, resulting in a reduction of postprandial hyperglycemia.	Starch	74-80	sucrase-isomaltase	Homo sapiens	14-31
19772492-1	2009	Inhibition of alpha-glucosidase and alpha-amylase delays the digestion of starch and disaccharides to absorbable monosaccharides, resulting in a reduction of postprandial hyperglycemia.	Disaccharides	85-98	sucrase-isomaltase	Homo sapiens	14-31
19772492-1	2009	Inhibition of alpha-glucosidase and alpha-amylase delays the digestion of starch and disaccharides to absorbable monosaccharides, resulting in a reduction of postprandial hyperglycemia.	Monosaccharides	113-128	sucrase-isomaltase	Homo sapiens	14-31
19772492-3	2009	We investigated the inhibitory activity of cinnamic acid derivatives against rat intestinal alpha-glucosidase and porcine pancreatic alpha-amylase in vitro.	cinnamic acid	43-56	sucrase-isomaltase	Homo sapiens	92-109
19689250-1	2009	The alpha-glucosidase inhibitor acarbose is administered to control blood glucose levels in type 2 diabetic patients and, in several countries, in those with impaired glucose tolerance.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
19689250-1	2009	The alpha-glucosidase inhibitor acarbose is administered to control blood glucose levels in type 2 diabetic patients and, in several countries, in those with impaired glucose tolerance.	Blood Glucose	68-81	sucrase-isomaltase	Homo sapiens	4-21
19505462-1	2009	The major side-effect of treatment with alpha-glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation.	Carbohydrates	105-118	sucrase-isomaltase	Homo sapiens	40-57
19505462-2	2009	We propose that the cardiovascular benefits of alpha-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H(2) in the gastrointestinal tract.	Hydrogen	176-180	sucrase-isomaltase	Homo sapiens	47-64
19505462-3	2009	Acarbose, which is an alpha-glucosidase inhibitor, markedly increased H(2) production, with a weaker effect on methane production.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	22-39
19505462-3	2009	Acarbose, which is an alpha-glucosidase inhibitor, markedly increased H(2) production, with a weaker effect on methane production.	Hydrogen	70-74	sucrase-isomaltase	Homo sapiens	22-39
19371716-1	2009	Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder.	Glycogen	53-61	sucrase-isomaltase	Homo sapiens	13-30
19371716-4	2009	We have developed a new fluorogenic substrate for the alpha-glucosidase enzyme assay, resorufin alpha-d-glucopyranoside.	resorufin	86-95	sucrase-isomaltase	Homo sapiens	54-71
19371716-4	2009	We have developed a new fluorogenic substrate for the alpha-glucosidase enzyme assay, resorufin alpha-d-glucopyranoside.	alpha-d-glucopyranoside	96-119	sucrase-isomaltase	Homo sapiens	54-71
19293774-3	2009	We showed that coincubation of Pompe fibroblasts with recombinant human alpha-glucosidase and the chaperone N-butyldeoxynojirimycin (NB-DNJ) resulted in more efficient correction of enzyme activity.	miglustat	108-131	sucrase-isomaltase	Homo sapiens	72-89
19568704-1	2009	INTRODUCTION: In this study, we examined the effects of the alpha-glucosidase inhibitors acarbose and voglibose on postprandial plasma glucose and serum triglyceride levels in patients with type 2 diabetes mellitus.	Acarbose	89-97	sucrase-isomaltase	Homo sapiens	60-77
19568704-1	2009	INTRODUCTION: In this study, we examined the effects of the alpha-glucosidase inhibitors acarbose and voglibose on postprandial plasma glucose and serum triglyceride levels in patients with type 2 diabetes mellitus.	Glucose	135-142	sucrase-isomaltase	Homo sapiens	60-77
19568704-1	2009	INTRODUCTION: In this study, we examined the effects of the alpha-glucosidase inhibitors acarbose and voglibose on postprandial plasma glucose and serum triglyceride levels in patients with type 2 diabetes mellitus.	Triglycerides	153-165	sucrase-isomaltase	Homo sapiens	60-77
19293774-3	2009	We showed that coincubation of Pompe fibroblasts with recombinant human alpha-glucosidase and the chaperone N-butyldeoxynojirimycin (NB-DNJ) resulted in more efficient correction of enzyme activity.	miglustat	133-139	sucrase-isomaltase	Homo sapiens	72-89
19361223-0	2009	Total synthesis of the alpha-glucosidase inhibitors schulzeine A, B, and C and a structural revision of schulzeine A.	schulzeine A	52-64	sucrase-isomaltase	Homo sapiens	23-40
19362832-3	2009	The butenoyl C- and alkanoyl C-glycosides were evaluated for their alpha-glucosidase, glucose-6-phosphatse and glycogen phosphorylase enzyme inhibitory activities in vitro.	butenoyl c- and alkanoyl c-glycosides	4-41	sucrase-isomaltase	Homo sapiens	67-84
19395079-2	2009	We therefore assessed whether voglibose, an alpha-glucosidase inhibitor, could prevent the development of type 2 diabetes in high-risk Japanese individuals with impaired glucose tolerance.	voglibose	30-39	sucrase-isomaltase	Homo sapiens	44-61
19361223-0	2009	Total synthesis of the alpha-glucosidase inhibitors schulzeine A, B, and C and a structural revision of schulzeine A.	schulzeine A	104-116	sucrase-isomaltase	Homo sapiens	23-40
19361223-1	2009	The enantioselective total synthesis of the potent alpha-glucosidase inhibitors schulzeine A, B, and C and a revision of the proposed C20" configuration of schulzeine A are reported.	schulzeine A	80-92	sucrase-isomaltase	Homo sapiens	51-68
19059289-1	2009	The C7N-cyclitol containing alpha-glucosidase inhibitor acarbose is commercially produced using developed strains of Actinoplanes and is used in the treatment of patients suffering from diabetes type II.	c7n-cyclitol	4-16	sucrase-isomaltase	Homo sapiens	28-45
19059289-1	2009	The C7N-cyclitol containing alpha-glucosidase inhibitor acarbose is commercially produced using developed strains of Actinoplanes and is used in the treatment of patients suffering from diabetes type II.	Acarbose	56-64	sucrase-isomaltase	Homo sapiens	28-45
19061152-2	2009	Recent trials demonstrated a reduction of cardiovascular events by treatment with alpha-glucosidase inhibitor acarbose - a drug which mainly reduces postprandial glucose excursions.	acarbose - a	110-122	sucrase-isomaltase	Homo sapiens	82-99
19167896-0	2009	Stereoselective synthesis of bioactive isosteviol derivatives as alpha-glucosidase inhibitors.	isosteviol	39-49	sucrase-isomaltase	Homo sapiens	65-82
19167896-2	2009	In this project, a series of novel compounds containing hydroxyl, hydroxymethyl group and heteroatom-containing frameworks fused with isosteviol structure were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation.	isosteviol	134-144	sucrase-isomaltase	Homo sapiens	189-206
19167896-3	2009	The results indicated that these isosteviol derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities.	isosteviol	33-43	sucrase-isomaltase	Homo sapiens	92-109
19167896-4	2009	Among them, indole derivative 15b exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors.	indole	12-18	sucrase-isomaltase	Homo sapiens	144-161
19275550-0	2009	Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders.	Acarbose	20-28	sucrase-isomaltase	Homo sapiens	33-50
19275550-5	2009	Acarbose, an alpha-glucosidase inhibitor, delays the absorption of carbohydrate from the small intestine, thereby reducing postprandial hyperglycemia.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
19275550-5	2009	Acarbose, an alpha-glucosidase inhibitor, delays the absorption of carbohydrate from the small intestine, thereby reducing postprandial hyperglycemia.	Carbohydrates	67-79	sucrase-isomaltase	Homo sapiens	13-30
19061152-2	2009	Recent trials demonstrated a reduction of cardiovascular events by treatment with alpha-glucosidase inhibitor acarbose - a drug which mainly reduces postprandial glucose excursions.	Glucose	162-169	sucrase-isomaltase	Homo sapiens	82-99
18615280-0	2009	alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.	cyanidin 3-galactoside	41-63	sucrase-isomaltase	Homo sapiens	0-17
18615280-0	2009	alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.	Acarbose	92-100	sucrase-isomaltase	Homo sapiens	0-17
18615280-3	2009	A low dose of cyanidin-3-galactoside showed a synergistic inhibition on intestinal alpha-glucosidase (maltase and sucrase) when combined with acarbose.	cyanidin 3-galactoside	14-36	sucrase-isomaltase	Homo sapiens	83-100
18615280-5	2009	The results indicated that cyanidin-3-galactoside was an alpha-glucosidase inhibitor and could be used in combination with acarbose for treatment of diabetes.	cyanidin 3-galactoside	27-49	sucrase-isomaltase	Homo sapiens	57-74
19350821-0	2009	[Synthesis and alpha-glucosidase inhibitory activity of N-(1,5-diaryl-3-pentone-1-yl)-4-aminobenzoic acid].	n-(1,5-diaryl-3-pentone-1-yl)-4-aminobenzoic acid	56-105	sucrase-isomaltase	Homo sapiens	15-32
19199993-1	2009	Alpha-glucosidase inhibitors are marketed as therapeutic drugs for diabetes that act through the inhibition of carbohydrate metabolism.	Carbohydrates	111-123	sucrase-isomaltase	Homo sapiens	0-17
19199996-1	2009	5a-Carba-alpha-D-glucopyranosylamine, validamine, and analogous compounds valienamine and valiolamine, have proved to be important lead compounds for development of clinically useful medicines, including the very strong alpha-glucosidase inhibitor, voglibose, N-(1,3-dihydroxyprop-2-yl)valiolamine, now used widely as a clinically important antidiabetic agent.	5a-carba-alpha-d-glucopyranosylamine	0-36	sucrase-isomaltase	Homo sapiens	220-237
19199996-1	2009	5a-Carba-alpha-D-glucopyranosylamine, validamine, and analogous compounds valienamine and valiolamine, have proved to be important lead compounds for development of clinically useful medicines, including the very strong alpha-glucosidase inhibitor, voglibose, N-(1,3-dihydroxyprop-2-yl)valiolamine, now used widely as a clinically important antidiabetic agent.	validamine	38-48	sucrase-isomaltase	Homo sapiens	220-237
19199996-1	2009	5a-Carba-alpha-D-glucopyranosylamine, validamine, and analogous compounds valienamine and valiolamine, have proved to be important lead compounds for development of clinically useful medicines, including the very strong alpha-glucosidase inhibitor, voglibose, N-(1,3-dihydroxyprop-2-yl)valiolamine, now used widely as a clinically important antidiabetic agent.	valienamine	74-85	sucrase-isomaltase	Homo sapiens	220-237
19199996-1	2009	5a-Carba-alpha-D-glucopyranosylamine, validamine, and analogous compounds valienamine and valiolamine, have proved to be important lead compounds for development of clinically useful medicines, including the very strong alpha-glucosidase inhibitor, voglibose, N-(1,3-dihydroxyprop-2-yl)valiolamine, now used widely as a clinically important antidiabetic agent.	valiolamine	90-101	sucrase-isomaltase	Homo sapiens	220-237
18827392-1	2008	In our continuous search for alpha-glucosidase inhibitors from plants, four new depsidones named brevipsidones A-D (1-4) were isolated from stem bark of Garcinia brevipedicellata together with known damnacanthal, scopoletin and a mixture of stigmasterol and beta-sitosterol.	brevipsidones a-d	97-114	sucrase-isomaltase	Homo sapiens	29-46
19080275-3	2008	We hypothesized that acarbose (alpha-glucosidase inhibitor), a hypoglycemic agent that decreases the rate of glucose absorption in the small intestine, would attenuate PPH in the elderly, and would be safe in the treatment.	Glucose	109-116	sucrase-isomaltase	Homo sapiens	31-48
19080275-3	2008	We hypothesized that acarbose (alpha-glucosidase inhibitor), a hypoglycemic agent that decreases the rate of glucose absorption in the small intestine, would attenuate PPH in the elderly, and would be safe in the treatment.	[(1R)-1-amino-2-phenylethyl]phosphonic acid	168-171	sucrase-isomaltase	Homo sapiens	31-48
18783210-0	2008	Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors.	Chlorogenic Acid	0-16	sucrase-isomaltase	Homo sapiens	93-110
18783210-3	2008	Here, we report the synthesis and alpha-glucosidase inhibitory activity of mono- and diketal/acetal derivatives of chlorogenic acid.	Chlorogenic Acid	115-131	sucrase-isomaltase	Homo sapiens	34-51
18958624-1	2008	The dietary intake and control of blood glucose levels are very important in hyperglycemic patients and alpha-glucosidase inhibitors are a cost-effective means to preventing the progression of diabetes.	Glucose	40-47	sucrase-isomaltase	Homo sapiens	104-121
18958624-3	2008	Methanolic extract of E. stolonifera (MEE), which contains a high content of polyphenols, showed strong inhibition of alpha-glucosidase in vitro.	methanolic	0-10	sucrase-isomaltase	Homo sapiens	118-135
18958624-3	2008	Methanolic extract of E. stolonifera (MEE), which contains a high content of polyphenols, showed strong inhibition of alpha-glucosidase in vitro.	Polyphenols	77-88	sucrase-isomaltase	Homo sapiens	118-135
19080275-3	2008	We hypothesized that acarbose (alpha-glucosidase inhibitor), a hypoglycemic agent that decreases the rate of glucose absorption in the small intestine, would attenuate PPH in the elderly, and would be safe in the treatment.	Acarbose	21-29	sucrase-isomaltase	Homo sapiens	31-48
18507653-0	2008	Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients.	voglibose	28-37	sucrase-isomaltase	Homo sapiens	0-17
18389516-8	2008	Our structural development studies on thalidomide are reviewed focusing on recent development of tubulin polymerization inhibitors, alpha-glucosidase inhibitors, and nuclear liver X receptors antagonists.	Thalidomide	38-49	sucrase-isomaltase	Homo sapiens	132-149
19019308-1	2008	Glycogen storage disease type II (GSDII)/Pompe disease is an autosomal recessive multi-system disorder due to a deficiency of the glycogen-degrading lysosomal enzyme, acid alpha-glucosidase.	Glycogen	130-138	sucrase-isomaltase	Homo sapiens	172-189
18721256-1	2008	AIM: alpha-Glucosidase inhibitors (alphaGIs) primarily modify postprandial plasma glucose levels and should be taken just before meals.	Glucose	82-89	sucrase-isomaltase	Homo sapiens	5-22
18507653-0	2008	Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients.	Pioglitazone	50-62	sucrase-isomaltase	Homo sapiens	0-17
18632275-0	2008	Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as alpha-glucosidase inhibitors.	xanthone	52-60	sucrase-isomaltase	Homo sapiens	76-93
18524587-1	2008	Discovery of alpha-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and the other carbohydrate-mediated diseases.	Carbohydrates	149-161	sucrase-isomaltase	Homo sapiens	13-30
18632275-1	2008	Xanthones and their derivatives have been reported to exhibit strong inhibitory activities toward alpha-glucosidase.	Xanthones	0-9	sucrase-isomaltase	Homo sapiens	98-115
18600280-0	2008	Synthesis of polyhydroxy piperidines and their analogues: a novel approach towards selective inhibitors of alpha-glucosidase.	polyhydroxy piperidines	13-36	sucrase-isomaltase	Homo sapiens	107-124
18600280-2	2008	Out of these polyhydroxy piperidine azasugars, 22, 39 and 20 were found to be potent as well as selective inhibitors of alpha-glucosidase with K(i) values ranging as low as 1.07 microM, 16.4 microM, and 88.2 microM, respectively.	polyhydroxy piperidine azasugars	13-45	sucrase-isomaltase	Homo sapiens	120-137
18685194-1	2008	Mulberry 1-deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor.	mulberry 1-deoxynojirimycin	0-27	sucrase-isomaltase	Homo sapiens	46-63
18685194-1	2008	Mulberry 1-deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor.	1-DEOXYNOJIRIMYCIN	29-32	sucrase-isomaltase	Homo sapiens	46-63
18553919-8	2008	In contrast, the alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen exhibited a 3.0-fold improved inhibition potency against rat intestine alpha-glucosidase with 0.3-fold inhibition potency against human pancreatic alpha-amylase relative to acarbose.	Acarbose	251-259	sucrase-isomaltase	Homo sapiens	149-166
18553919-9	2008	In conclusion, alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen is a novel alpha-glucosidase-selective inhibitor with 10-fold enhanced selectivity toward alpha-glucosidase over alpha-amylase relative to acarbose, and it could be applied as a potent hypoglycemic agent.	-acarviosinyl	20-33	sucrase-isomaltase	Homo sapiens	87-104
18553919-9	2008	In conclusion, alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen is a novel alpha-glucosidase-selective inhibitor with 10-fold enhanced selectivity toward alpha-glucosidase over alpha-amylase relative to acarbose, and it could be applied as a potent hypoglycemic agent.	-acarviosinyl	20-33	sucrase-isomaltase	Homo sapiens	166-183
18553919-9	2008	In conclusion, alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen is a novel alpha-glucosidase-selective inhibitor with 10-fold enhanced selectivity toward alpha-glucosidase over alpha-amylase relative to acarbose, and it could be applied as a potent hypoglycemic agent.	methylphenyl carbinol	15-20	sucrase-isomaltase	Homo sapiens	87-104
18553919-9	2008	In conclusion, alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen is a novel alpha-glucosidase-selective inhibitor with 10-fold enhanced selectivity toward alpha-glucosidase over alpha-amylase relative to acarbose, and it could be applied as a potent hypoglycemic agent.	methylphenyl carbinol	15-20	sucrase-isomaltase	Homo sapiens	166-183
18553919-9	2008	In conclusion, alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen is a novel alpha-glucosidase-selective inhibitor with 10-fold enhanced selectivity toward alpha-glucosidase over alpha-amylase relative to acarbose, and it could be applied as a potent hypoglycemic agent.	d-glucopyranosylpropen	53-75	sucrase-isomaltase	Homo sapiens	87-104
18553919-9	2008	In conclusion, alpha-acarviosinyl-(1--&gt;9)-3-alpha-D-glucopyranosylpropen is a novel alpha-glucosidase-selective inhibitor with 10-fold enhanced selectivity toward alpha-glucosidase over alpha-amylase relative to acarbose, and it could be applied as a potent hypoglycemic agent.	d-glucopyranosylpropen	53-75	sucrase-isomaltase	Homo sapiens	166-183
18480556-3	2008	alpha-glucosidase inhibitors are another class of anti-diabetic agents that specifically reduce postprandial blood glucose elevations, but its effect on adiponectin is largely unknown.	Blood Glucose	109-122	sucrase-isomaltase	Homo sapiens	0-17
18248270-1	2008	Acarbose is an alpha-glucosidase inhibitor acting specifically at the level of postprandial glucose excursion.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	15-32
26065759-1	2008	Methanolic extracts from the medicinal parts of 40 traditional Chinese herbs were tested in screening experiments for rat intestinal alpha-glucosidase.	methanolic	0-10	sucrase-isomaltase	Homo sapiens	133-150
26065759-6	2008	Kinetic data revealed that compounds 1 and 2 inhibited sucrose-hydrolysing activity of rat intestinal alpha-glucosidase competitively with Ki values of 82muM and 183muM, respectively.	Sucrose	55-62	sucrase-isomaltase	Homo sapiens	102-119
18343126-2	2008	On this basis, we have already developed novel LXR antagonists based upon alpha-glucosidase inhibitors derived from thalidomide.	Thalidomide	116-127	sucrase-isomaltase	Homo sapiens	74-91
18343126-6	2008	To test this idea, we focused on riccardin C, a naturally occurring LXR ligand, which we found here to be a potent alpha-glucosidase inhibitor as well.	riccardin	33-42	sucrase-isomaltase	Homo sapiens	115-132
18415855-0	2008	Microbial transformation of oleanolic acid by Fusarium lini and alpha-glucosidase inhibitory activity of its transformed products.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	64-81
18397692-1	2008	UNLABELLED: Sucrose is divided by alpha-glucosidase into fructose and glucose, which are considered to raise plasma uric acid concentration through purine degradation and/or decreased uric acid excretion.	Uric Acid	116-125	sucrase-isomaltase	Homo sapiens	34-51
18397692-1	2008	UNLABELLED: Sucrose is divided by alpha-glucosidase into fructose and glucose, which are considered to raise plasma uric acid concentration through purine degradation and/or decreased uric acid excretion.	purine	148-154	sucrase-isomaltase	Homo sapiens	34-51
18397692-1	2008	UNLABELLED: Sucrose is divided by alpha-glucosidase into fructose and glucose, which are considered to raise plasma uric acid concentration through purine degradation and/or decreased uric acid excretion.	Uric Acid	184-193	sucrase-isomaltase	Homo sapiens	34-51
18397692-2	2008	AIMS: We investigated the effect of acarbose, an alpha-glucosidase inhibitor, on the increased plasma concentration of uric acid caused by sucrose.	Acarbose	36-44	sucrase-isomaltase	Homo sapiens	49-66
18397692-2	2008	AIMS: We investigated the effect of acarbose, an alpha-glucosidase inhibitor, on the increased plasma concentration of uric acid caused by sucrose.	Uric Acid	119-128	sucrase-isomaltase	Homo sapiens	49-66
18397692-2	2008	AIMS: We investigated the effect of acarbose, an alpha-glucosidase inhibitor, on the increased plasma concentration of uric acid caused by sucrose.	Sucrose	139-146	sucrase-isomaltase	Homo sapiens	49-66
17983356-7	2008	Endo H (endoglycosidase H) treatment and cell culture with alpha-glucosidase inhibitors demonstrated that N-linked glycans are of the complex mature type in the 170 kDa form and of the high-mannose type in the 130 kDa form.	n-linked glycans	106-122	sucrase-isomaltase	Homo sapiens	59-76
18600518-2	2008	To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose.	Acarbose	26-34	sucrase-isomaltase	Homo sapiens	52-69
18374320-6	2008	In an in vivo study using Goto-Kakizaki (GK) rats, the acetone extract was found to be a potent inhibitor of alpha-glucosidase hydrolysis of maltose when compared to untreated control animals.	Acetone	55-62	sucrase-isomaltase	Homo sapiens	109-126
18374320-6	2008	In an in vivo study using Goto-Kakizaki (GK) rats, the acetone extract was found to be a potent inhibitor of alpha-glucosidase hydrolysis of maltose when compared to untreated control animals.	Maltose	141-148	sucrase-isomaltase	Homo sapiens	109-126
18230353-0	2008	The alpha-glucosidase inhibitor acarbose reduces the net electronegative charge of low-density lipoprotein in patients with newly diagnosed type 2 diabetes.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
18248270-1	2008	Acarbose is an alpha-glucosidase inhibitor acting specifically at the level of postprandial glucose excursion.	Glucose	92-99	sucrase-isomaltase	Homo sapiens	15-32
17868040-0	2008	Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition.	Oligosaccharides	18-34	sucrase-isomaltase	Homo sapiens	76-93
17920282-1	2008	Discovery of alpha-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and the other carbohydrate mediated diseases.	Carbohydrates	149-161	sucrase-isomaltase	Homo sapiens	13-30
19003770-1	2008	Pompe disease (glycogen-storage disease type II) is an autosomal recessive disorder caused by a deficiency of lysosomal acid alpha-glucosidase (GAA), leading to the accumulation of glycogen in the lysosomes primarily in muscle cells.	Glycogen	15-23	sucrase-isomaltase	Homo sapiens	125-142
18647188-9	2008	RESULTS: One week and three months after the start of the concomitant use of the alpha-glucosidase inhibitor, the area under the concentration curve for plasma glucose was significantly decreased.	Glucose	160-167	sucrase-isomaltase	Homo sapiens	81-98
18647188-12	2008	CONCLUSION: The concomitant use of the alpha-glucosidase inhibitor use with LES showed the possibility of improving glucose tolerance and energy metabolism.	Glucose	116-123	sucrase-isomaltase	Homo sapiens	39-56
18318124-1	2007	Maltase-glucoamylase and sucrase-isomaltase are two human glycosidases responsible for starch digestion.	Starch	87-93	sucrase-isomaltase	Homo sapiens	25-43
17693318-0	2007	Alpha-glucosidase based bismuth film electrode for inhibitor detection.	Bismuth	24-31	sucrase-isomaltase	Homo sapiens	0-17
17493703-1	2007	Miglitol, a pseudomonosaccharide alpha-glucosidase inhibitor (alphaGI), was more effective at reducing blood glucose levels at 30 and 60 min after a meal than voglibose.	miglitol	0-8	sucrase-isomaltase	Homo sapiens	33-50
17697384-4	2007	The efficacy, safety and tolerability of the alpha-glucosidase inhibitor acarbose have been well-established in a wide range of patient populations in both clinical and community trials.	Acarbose	73-81	sucrase-isomaltase	Homo sapiens	45-62
17559821-2	2007	Salacinol, a naturally occurring alpha-glucosidase inhibitor, was shown to be one of the active principles of the aqueous extract of a medicinal plant that has been prescribed traditionally as an Ayurvedic treatment for type II diabetes.	salacinol	0-9	sucrase-isomaltase	Homo sapiens	33-50
17693318-1	2007	A biosensing system based on alpha-glucosidase (AG) activity was developed by using bismuth film modified glassy carbon electrode (BiFE).	Bismuth	84-91	sucrase-isomaltase	Homo sapiens	29-46
17693318-1	2007	A biosensing system based on alpha-glucosidase (AG) activity was developed by using bismuth film modified glassy carbon electrode (BiFE).	Bismuth	84-91	sucrase-isomaltase	Homo sapiens	48-50
17693318-1	2007	A biosensing system based on alpha-glucosidase (AG) activity was developed by using bismuth film modified glassy carbon electrode (BiFE).	Carbon	113-119	sucrase-isomaltase	Homo sapiens	29-46
17693318-1	2007	A biosensing system based on alpha-glucosidase (AG) activity was developed by using bismuth film modified glassy carbon electrode (BiFE).	Carbon	113-119	sucrase-isomaltase	Homo sapiens	48-50
17693318-1	2007	A biosensing system based on alpha-glucosidase (AG) activity was developed by using bismuth film modified glassy carbon electrode (BiFE).	bife	131-135	sucrase-isomaltase	Homo sapiens	29-46
17693318-1	2007	A biosensing system based on alpha-glucosidase (AG) activity was developed by using bismuth film modified glassy carbon electrode (BiFE).	bife	131-135	sucrase-isomaltase	Homo sapiens	48-50
17498949-1	2007	Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity.	chlorinated phthalimide	36-59	sucrase-isomaltase	Homo sapiens	0-17
22504367-0	2007	Modification of 15-akylidene andrographolide derivatives as alpha-glucosidase inhibitor.	15-akylidene	16-28	sucrase-isomaltase	Homo sapiens	60-77
22504367-1	2007	15-Alkylidene andrographolide derivatives were specific alpha-glucosidase inhibitors.	15-alkylidene andrographolide	0-29	sucrase-isomaltase	Homo sapiens	56-73
17572127-2	2007	Intravenous administration of recombinant human alpha-glucosidase (rhGAA, Myozyme, aglucosidase alfa) can result in significant glycogen clearance from both cardiomyocytes and skeletal myocytes, however, the degree of clearance varies from one skeletal muscle type to another.	Glycogen	128-136	sucrase-isomaltase	Homo sapiens	48-65
17498949-1	2007	Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity.	THIOPHTHALIMIDE	65-80	sucrase-isomaltase	Homo sapiens	0-17
17498949-1	2007	Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity.	Thalidomide	104-115	sucrase-isomaltase	Homo sapiens	0-17
17476502-3	2007	(2S,3R)-HCA inhibits pancreatic alpha-amylase and intestinal alpha-glucosidase, leading to a reduction in carbohydrate metabolism.	(2s,3r)-hca	0-11	sucrase-isomaltase	Homo sapiens	61-78
17476502-3	2007	(2S,3R)-HCA inhibits pancreatic alpha-amylase and intestinal alpha-glucosidase, leading to a reduction in carbohydrate metabolism.	Carbohydrates	106-118	sucrase-isomaltase	Homo sapiens	61-78
17434740-2	2007	D-aminothreose was a potent inhibitor of alpha-glucosidase and of alpha-mannosidase.	d-aminothreose	0-14	sucrase-isomaltase	Homo sapiens	41-58
17187956-0	2007	Antidiabetic activity of lipophilic (-)-epigallocatechin-3-gallate derivative under its role of alpha-glucosidase inhibition.	epigallocatechin gallate	36-66	sucrase-isomaltase	Homo sapiens	96-113
17270480-1	2007	The enzymatic defect in Pompe disease is insufficient lysosomal acid alpha-glucosidase (GAA) activity which leads to lysosomal glycogen accumulation.	Glycogen	127-135	sucrase-isomaltase	Homo sapiens	69-86
17270480-2	2007	We recently introduced a simple and reliable method to measure GAA activity in dried blood spots using Acarbose, a highly selective alpha-glucosidase inhibitor, to eliminate isoenzyme interference.	Acarbose	103-111	sucrase-isomaltase	Homo sapiens	132-149
17188491-0	2007	Diastereoselective synthesis of glycosylated prolines as alpha-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction.	Proline	45-53	sucrase-isomaltase	Homo sapiens	57-74
17188491-3	2007	Few of the proline esters exhibited very good alpha-glucosidase inhibitory activity.	proline esters	11-25	sucrase-isomaltase	Homo sapiens	46-63
17270224-0	2007	alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).	pentacyclic	29-40	sucrase-isomaltase	Homo sapiens	0-17
17270224-0	2007	alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).	Triterpenes	41-52	sucrase-isomaltase	Homo sapiens	0-17
17194452-0	2007	HNF-1alpha participates in glucose regulation of sucrase-isomaltase gene expression in epithelial intestinal cells.	Glucose	27-34	sucrase-isomaltase	Homo sapiens	49-67
17194452-1	2007	Sucrase-isomaltase (SI) gene expression is negatively regulated by glucose, but its molecular mechanism is not completely clear.	Glucose	67-74	sucrase-isomaltase	Homo sapiens	0-18
17194452-1	2007	Sucrase-isomaltase (SI) gene expression is negatively regulated by glucose, but its molecular mechanism is not completely clear.	Glucose	67-74	sucrase-isomaltase	Homo sapiens	20-22
17194452-5	2007	Moreover, to elucidate whether glucose regulation of SI gene expression is changed when HNF-1alpha and HNF-1beta are inhibited, we produced three stable cell lines, in which dominant-negative mutant HNF-1alphaT539fsdelC, mutant HNF-1betaR177X, and empty vector (as a control), respectively, were stably expressed.	Glucose	31-38	sucrase-isomaltase	Homo sapiens	53-55
17194452-6	2007	We found that the glucose regulation of SI gene expression was significantly attenuated in HNF-1alphaT539fsdelC cells, but it was well maintained in empty vector and HNF-1betaR177X cells.	Glucose	18-25	sucrase-isomaltase	Homo sapiens	40-42
17268097-4	2007	The inhibitory activity of the terpenoid derivatives against alpha-glucosidase was investigated and compounds 1, 3, 7, and 9 were found to exhibit potent activity.	Terpenes	31-40	sucrase-isomaltase	Homo sapiens	61-78
17222224-3	2007	Previous studies showed that the disruption of early ER N-glycan processing by deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase, suppresses tyrosinase enzymatic activity and melanogenesis.	n-glycan	56-64	sucrase-isomaltase	Homo sapiens	119-136
17222224-3	2007	Previous studies showed that the disruption of early ER N-glycan processing by deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase, suppresses tyrosinase enzymatic activity and melanogenesis.	1-Deoxynojirimycin	79-95	sucrase-isomaltase	Homo sapiens	119-136
17222224-3	2007	Previous studies showed that the disruption of early ER N-glycan processing by deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase, suppresses tyrosinase enzymatic activity and melanogenesis.	1-Deoxynojirimycin	97-100	sucrase-isomaltase	Homo sapiens	119-136
17615973-5	2007	The results obtained were statistically calculated with an SPSS 12.0 program to evaluate the difference between the control group and the infertile one and the correlation of the free L-carnitine levels with the seminal plasma components of alpha-glucosidase, fructose and acid phosphatase.	Carnitine	184-195	sucrase-isomaltase	Homo sapiens	241-258
17615973-7	2007	There was a statistically significant positive correlation between seminal plasma free L-carnitine level and alpha-glucosidase activity (r = 0.504, P &lt; 0.001.	Carnitine	87-98	sucrase-isomaltase	Homo sapiens	109-126
17336855-2	2007	Alpha-glucosidase inhibitors delay intestinal absorption of carbohydrates and reduce postprandial glycemia.	Carbohydrates	60-73	sucrase-isomaltase	Homo sapiens	0-17
17187956-8	2007	And activity of alpha-glucosidase was inhibited by 50% at the concentration of 246.6 microg ml(-1) L-EGCGd.	l-egcgd	99-106	sucrase-isomaltase	Homo sapiens	16-33
17187956-9	2007	As a result, we first demonstrated that the purified form of compound L-EGCGd possessed the hypoglycemic effect under its role of alpha-glucosidase inhibition, and therefore should be possibly accepted as an alternative oral medication protecting patients against postprandial hyperglycemic toxicity on the treatment of diabetes and its complications.	l-egcgd	70-77	sucrase-isomaltase	Homo sapiens	130-147
16730076-3	2006	The alpha-glucosidase inhibitors (castanospermine, 1-deoxynojirimycin) in recombinant expression systems reduced the surface and intracellular expression of both HPIV3 F and HN proteins.	castanospermine	34-49	sucrase-isomaltase	Homo sapiens	4-21
17056254-1	2007	Pompe disease is an autosomal recessive disorder caused by a deficiency in 1,4-alpha-glucosidase (EC.3.2.1.3), the enzyme required to hydrolyze lysosomal glycogen to glucose.	Glycogen	154-162	sucrase-isomaltase	Homo sapiens	79-96
17056254-1	2007	Pompe disease is an autosomal recessive disorder caused by a deficiency in 1,4-alpha-glucosidase (EC.3.2.1.3), the enzyme required to hydrolyze lysosomal glycogen to glucose.	Glucose	166-173	sucrase-isomaltase	Homo sapiens	79-96
16966825-4	2006	Administration of small doses of alpha-glucosidase inhibitor (alpha-GI) dramatically inhibited the rapid rise and subsequent precipitous fall of plasma glucose.	Glucose	152-159	sucrase-isomaltase	Homo sapiens	33-50
17054235-1	2006	BACKGROUND: Alpha-glucosidase inhibitors (AGIs) reduce blood glucose levels and may thus prevent type 2 diabetes and cardiovascular disease in patients with impaired glucose tolerance.	Blood Glucose	55-68	sucrase-isomaltase	Homo sapiens	12-29
16730076-3	2006	The alpha-glucosidase inhibitors (castanospermine, 1-deoxynojirimycin) in recombinant expression systems reduced the surface and intracellular expression of both HPIV3 F and HN proteins.	1-DEOXYNOJIRIMYCIN	51-69	sucrase-isomaltase	Homo sapiens	4-21
16730076-6	2006	We demonstrated that the alpha-glucosidase inhibitors (castanospermine and 1-deoxynojirimycin) reduced the infectivity of newly released viral particles.	castanospermine	55-70	sucrase-isomaltase	Homo sapiens	25-42
16730076-6	2006	We demonstrated that the alpha-glucosidase inhibitors (castanospermine and 1-deoxynojirimycin) reduced the infectivity of newly released viral particles.	1-DEOXYNOJIRIMYCIN	75-93	sucrase-isomaltase	Homo sapiens	25-42
17283864-6	2006	Furthermore, we tested whether correction of the abnormal glucose tolerance using voglibose (an alpha-glucosidase inhibitor) would improve the severity of CHF in another group of 30 patients with DCM-induced CHF and IGT.	voglibose	82-91	sucrase-isomaltase	Homo sapiens	96-113
16797996-0	2006	Search for alpha-glucosidase inhibitors: new N-substituted valienamine and conduramine F-1 derivatives.	n-substituted valienamine	45-70	sucrase-isomaltase	Homo sapiens	11-28
16797996-0	2006	Search for alpha-glucosidase inhibitors: new N-substituted valienamine and conduramine F-1 derivatives.	6-aminocyclohex-4-ene-1,2,3-triol	75-90	sucrase-isomaltase	Homo sapiens	11-28
17133782-0	2006	Acarbose, an alpha-glucosidase inhibitor, decreases aortic gene expression and serum levels of monocyte chemoattractant protein-1 in fructose-fed rats.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
16624372-2	2006	Temperature and pH optima studies showed temperature optima of 50 degrees C and pH optima of 8.0 for the alpha-glucosidases from both the MR and SR. Sulfide (at a concentration of 150 mg l(-1)) resulted in the complete loss of all alpha-glucosidase activity in both the MR and SR. beta-Glucosidase activities in our bioreactors were previously shown to be stimulated in the presence of sulfide.	Sulfides	149-156	sucrase-isomaltase	Homo sapiens	105-122
16624372-2	2006	Temperature and pH optima studies showed temperature optima of 50 degrees C and pH optima of 8.0 for the alpha-glucosidases from both the MR and SR. Sulfide (at a concentration of 150 mg l(-1)) resulted in the complete loss of all alpha-glucosidase activity in both the MR and SR. beta-Glucosidase activities in our bioreactors were previously shown to be stimulated in the presence of sulfide.	Sulfides	386-393	sucrase-isomaltase	Homo sapiens	105-122
16624372-4	2006	This differential effect of sulfide on alpha-glucosidase and beta-glucosidase activities is highlighted and is of crucial consequence to the respective degradation and utilization of starch and cellulose substrates in natural anaerobic environments and anaerobic bioreactors specifically designed for the accelerated digestion of wastewater sludge under biosulfidogenic conditions.	Sulfides	28-35	sucrase-isomaltase	Homo sapiens	39-56
16624372-4	2006	This differential effect of sulfide on alpha-glucosidase and beta-glucosidase activities is highlighted and is of crucial consequence to the respective degradation and utilization of starch and cellulose substrates in natural anaerobic environments and anaerobic bioreactors specifically designed for the accelerated digestion of wastewater sludge under biosulfidogenic conditions.	Starch	183-189	sucrase-isomaltase	Homo sapiens	39-56
16624372-4	2006	This differential effect of sulfide on alpha-glucosidase and beta-glucosidase activities is highlighted and is of crucial consequence to the respective degradation and utilization of starch and cellulose substrates in natural anaerobic environments and anaerobic bioreactors specifically designed for the accelerated digestion of wastewater sludge under biosulfidogenic conditions.	Cellulose	194-203	sucrase-isomaltase	Homo sapiens	39-56
17375403-3	2006	Alpha-glucosidase inhibitors can reduce PPG by a mean 0.50 g/l, no matter what the insulin resistance or insulinopenia status or the other diabetes treatments already in use.	ppg	40-43	sucrase-isomaltase	Homo sapiens	0-17
16907758-6	2006	Measurements of Leucine aminopeptidase and alpha-glucosidase activities in fractionated lake water (0.2-1.2, 1.2-5 and &gt;5 microm fractions) indicated that proteolytic activity was always higher and that particle-associated bacteria have higher enzymatic activities than free-living bacteria.	Water	93-98	sucrase-isomaltase	Homo sapiens	43-60
17133782-2	2006	Recently, acarbose, an alpha-glucosidase inhibitor that delays the absorption of carbohydrates from the small intestine, has been found to reduce the incidence of cardiovascular disease in patients with impaired glucose tolerance or diabetes.	Acarbose	10-18	sucrase-isomaltase	Homo sapiens	23-40
17133782-2	2006	Recently, acarbose, an alpha-glucosidase inhibitor that delays the absorption of carbohydrates from the small intestine, has been found to reduce the incidence of cardiovascular disease in patients with impaired glucose tolerance or diabetes.	Carbohydrates	81-94	sucrase-isomaltase	Homo sapiens	23-40
17007358-0	2006	Synthesis of a salacinol analogue and its alpha-glucosidase inhibitory activity.	salacinol	15-24	sucrase-isomaltase	Homo sapiens	42-59
16651002-0	2006	Synthesis and pharmacological activities of xanthone derivatives as alpha-glucosidase inhibitors.	xanthone	44-52	sucrase-isomaltase	Homo sapiens	68-85
16651002-2	2006	In this project, a series of hydroxylxanthones and their acetoxy and alkoxy derivatives were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation.	hydroxylxanthones	29-46	sucrase-isomaltase	Homo sapiens	122-139
16651002-3	2006	The results indicated that these xanthone derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities.	xanthone	33-41	sucrase-isomaltase	Homo sapiens	90-107
16651002-4	2006	Among them, polyhydroxylxanthones exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors.	polyhydroxylxanthones	12-33	sucrase-isomaltase	Homo sapiens	144-161
16846599-1	2006	alpha-Glucosidase (EC 3.2.1.3) is a lysosomal enzyme that hydrolyses alpha-1,4- and alpha-1,6-linkages of glycogen to produce free glucose.	Glycogen	106-114	sucrase-isomaltase	Homo sapiens	0-17
16846599-1	2006	alpha-Glucosidase (EC 3.2.1.3) is a lysosomal enzyme that hydrolyses alpha-1,4- and alpha-1,6-linkages of glycogen to produce free glucose.	Glucose	131-138	sucrase-isomaltase	Homo sapiens	0-17
16846599-3	2006	Here, d-glucose was shown to be a competitive inhibitor of alpha-glucosidase and when added to culture medium at 6.0 g/L increased the production of this protein by CHO-K1 expression cells and stabilised the enzyme activity.	Glucose	6-15	sucrase-isomaltase	Homo sapiens	59-76
16846599-4	2006	D-Glucose also prevented alpha-glucosidase aggregation/precipitation and increased protein yield in a modified purification scheme.	Glucose	0-9	sucrase-isomaltase	Homo sapiens	25-42
16846599-5	2006	In fibroblast cells, from adult-onset GSD II patients, D-glucose increased the residual level of alpha-glucosidase activity, suggesting that a structural analogue of d-glucose may be used for enzyme enhancement therapy.	Glucose	55-64	sucrase-isomaltase	Homo sapiens	97-114
16846599-5	2006	In fibroblast cells, from adult-onset GSD II patients, D-glucose increased the residual level of alpha-glucosidase activity, suggesting that a structural analogue of d-glucose may be used for enzyme enhancement therapy.	Glucose	166-175	sucrase-isomaltase	Homo sapiens	97-114
16713439-0	2006	An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients.	voglibose	32-41	sucrase-isomaltase	Homo sapiens	3-20
16817895-2	2006	Maltase-glucoamylase (MGA), a family 31 glycoside hydrolase, is an alpha-glucosidase anchored in the membrane of small intestinal epithelial cells responsible for the final step of mammalian starch digestion leading to the release of glucose.	Starch	191-197	sucrase-isomaltase	Homo sapiens	67-84
16817895-2	2006	Maltase-glucoamylase (MGA), a family 31 glycoside hydrolase, is an alpha-glucosidase anchored in the membrane of small intestinal epithelial cells responsible for the final step of mammalian starch digestion leading to the release of glucose.	Glucose	234-241	sucrase-isomaltase	Homo sapiens	67-84
16688114-3	2006	Small intestinal alpha-glucosidase inhibitors like Acarbose (Glucobay) enhance the amount of undigested carbohydrates reaching the colon.	Carbohydrates	104-117	sucrase-isomaltase	Homo sapiens	17-34
16713439-2	2006	This study was designed to elucidate whether improving the postprandial state by voglibose, an alpha-glucosidase inhibitor, leads to the reduction of oxidative stress markers and soluble adhesion molecules in obese type 2 diabetic patients.	voglibose	81-90	sucrase-isomaltase	Homo sapiens	95-112
16504503-0	2006	Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.	andrographolide	100-115	sucrase-isomaltase	Homo sapiens	21-38
16704229-0	2006	Planar catechin analogues with alkyl side chains: a potent antioxidant and an alpha-glucosidase inhibitor.	Catechin	7-15	sucrase-isomaltase	Homo sapiens	78-95
16704229-1	2006	Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and alpha-glucosidase inhibitory activities are shown.	Catechin	7-15	sucrase-isomaltase	Homo sapiens	133-150
16504503-1	2006	A series of analogues of andrographolide were synthesized and evaluated as novel alpha-glucosidase inhibitors.	andrographolide	25-40	sucrase-isomaltase	Homo sapiens	81-98
16504503-2	2006	Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against alpha-glucosidase whose IC(50) value was 16microM.	CHEMBL377520	24-88	sucrase-isomaltase	Homo sapiens	121-138
16586532-4	2006	For example, lactase-phloridzin hydrolase and sucrase-isomaltase are two disaccharidases involved in the hydrolysis of nutritionally important disaccharides.	Disaccharides	143-156	sucrase-isomaltase	Homo sapiens	46-64
16702880-0	2006	Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease.	Maltose	14-21	sucrase-isomaltase	Homo sapiens	99-116
16702880-0	2006	Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease.	Acarbose	26-34	sucrase-isomaltase	Homo sapiens	99-116
16702880-1	2006	PURPOSE: The study"s purpose was to compare acarbose and maltose as inhibitors of maltase-glucoamylase activity for determining acid alpha-glucosidase activity in dried blood spot specimens for early identification of patients with infantile Pompe disease, a severe form of acid alpha-glucosidase deficiency.	Acarbose	44-52	sucrase-isomaltase	Homo sapiens	133-150
16702880-2	2006	METHODS: Acid alpha-glucosidase activities in dried blood spot extracts were determined fluorometrically using the artificial substrate 4-methylumbelliferyl-alpha-D-pyranoside.	4-methylumbelliferyl-alpha-d-pyranoside	136-175	sucrase-isomaltase	Homo sapiens	14-31
16702880-3	2006	Acarbose or maltose was used to inhibit maltase-glucoamylase, an enzyme present in polymorphonuclear neutrophils that contributes to the total alpha-glucosidase activity at acidic pH.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	143-160
16702880-3	2006	Acarbose or maltose was used to inhibit maltase-glucoamylase, an enzyme present in polymorphonuclear neutrophils that contributes to the total alpha-glucosidase activity at acidic pH.	Maltose	12-19	sucrase-isomaltase	Homo sapiens	143-160
16702881-0	2006	The use of acarbose inhibition in the measurement of acid alpha-glucosidase activity in blood lymphocytes for the diagnosis of Pompe disease.	Acarbose	11-19	sucrase-isomaltase	Homo sapiens	58-75
16702881-3	2006	Enzyme measurement in an isolated lymphocyte population with acarbose, an inhibitor of neutral alpha-glucosidase, has greatly improved the sensitivity and specificity of the test in blood cells allowing for more rapid laboratory testing for Pompe disease.	Acarbose	61-69	sucrase-isomaltase	Homo sapiens	95-112
16528036-4	2006	alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding.	Glucose	46-53	sucrase-isomaltase	Homo sapiens	0-17
16528036-4	2006	alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding.	1-Deoxynojirimycin	63-79	sucrase-isomaltase	Homo sapiens	0-17
16528036-4	2006	alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding.	1-Deoxynojirimycin	81-84	sucrase-isomaltase	Homo sapiens	0-17
16528036-4	2006	alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding.	Nitrogen	82-83	sucrase-isomaltase	Homo sapiens	0-17
16528036-4	2006	alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding.	n-glycans	244-253	sucrase-isomaltase	Homo sapiens	0-17
16528036-7	2006	Here, it is demonstrated that, in the presence of these alpha-glucosidase inhibitors, viral glycoproteins synthesized and retained in the endoplasmic reticulum (i) contain unprocessed, triglucosylated N-glycans, (ii) are impaired in their interaction with calnexin and (iii) are at least partially misfolded.	n-glycans	201-210	sucrase-isomaltase	Homo sapiens	56-73
16368744-2	2006	A reduction of postprandial blood glucose levels by the alpha-glucosidase inhibitor acarbose was associated with a risk reduction of cardiovascular complications, but effects of acarbose on endothelial function have never been elucidated.	Glucose	34-41	sucrase-isomaltase	Homo sapiens	56-73
16508179-5	2006	The acridones 1, 4 and 5 showed potent activity against alpha-glucosidase, while the acridones 1-5 showed moderate free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).	acridones 1, 4 and 5	4-24	sucrase-isomaltase	Homo sapiens	56-73
16368744-2	2006	A reduction of postprandial blood glucose levels by the alpha-glucosidase inhibitor acarbose was associated with a risk reduction of cardiovascular complications, but effects of acarbose on endothelial function have never been elucidated.	Acarbose	84-92	sucrase-isomaltase	Homo sapiens	56-73
16125815-4	2006	In four starch-fed MBRs, the bacterial community substantially increased its alpha-glucosidase affinity (&gt;1000-fold), while the leucine aminopeptidase and heptanoate esterase affinities increased slightly (&lt;40-fold) or remained relatively constant.	Starch	8-14	sucrase-isomaltase	Homo sapiens	77-94
15901356-7	2005	beta-glucosidase or beta-galactosidase (lactase/phloridzin hydrolase, LPH) and alpha-glucosidase (sucrase-isomaltase) had different pH-dependent activities for disaccharide conjugates.	Disaccharides	160-172	sucrase-isomaltase	Homo sapiens	79-96
16440087-8	2006	Furthermore, the ability of these reagentless protein-nanoparticle assemblies to perform maltose biosensing reversibly is demonstrated with the addition of alpha-glucosidase.	Maltose	89-96	sucrase-isomaltase	Homo sapiens	156-173
16440087-9	2006	Three 50 microM maltose additions after alpha-glucosidase addition showed increases of 2.2 microM, 600 nM, and 150 nM maltose.	Maltose	16-23	sucrase-isomaltase	Homo sapiens	40-57
16440087-9	2006	Three 50 microM maltose additions after alpha-glucosidase addition showed increases of 2.2 microM, 600 nM, and 150 nM maltose.	Maltose	118-125	sucrase-isomaltase	Homo sapiens	40-57
16329100-0	2006	Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption.	Carbohydrates	80-92	sucrase-isomaltase	Homo sapiens	29-47
16329100-0	2006	Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption.	Carbohydrates	80-92	sucrase-isomaltase	Homo sapiens	54-56
16484742-2	2006	The patient started prednisone treatment, but one month later treatment with voglibose, an alpha-glucosidase inhibitor (alpha-GI), was started because of prednisone-induced diabetes mellitus.	voglibose	77-86	sucrase-isomaltase	Homo sapiens	91-108
15944403-0	2005	A phenylalanine-based folding determinant in intestinal sucrase-isomaltase that functions in the context of a quality control mechanism beyond the endoplasmic reticulum.	Phenylalanine	2-15	sucrase-isomaltase	Homo sapiens	56-74
15944403-2	2005	The transport block is due to the substitution of a glutamine by a proline at amino acid residue 1098 that generates a temperature-sensitive mutant enzyme, SI(Q1098P), the transport of which is regulated by several cycles of anterograde and retrograde transport between the ER and the cis-Golgi (Propsting, M. J., Jacob, R. and Naim, H. Y.	Glutamine	52-61	sucrase-isomaltase	Homo sapiens	156-158
15944403-2	2005	The transport block is due to the substitution of a glutamine by a proline at amino acid residue 1098 that generates a temperature-sensitive mutant enzyme, SI(Q1098P), the transport of which is regulated by several cycles of anterograde and retrograde transport between the ER and the cis-Golgi (Propsting, M. J., Jacob, R. and Naim, H. Y.	Proline	67-74	sucrase-isomaltase	Homo sapiens	156-158
15944403-8	2005	We have used alanine-scanning mutagenesis to screen upstream and downstream regions flanking Q(1098) and identified a putative motif, F(1093)-x-F(1095)-x-x-x-F(1099) that is likely to be implicated in sensing the folding and subsequent trafficking of SI from the ER to the Golgi.	Alanine	13-20	sucrase-isomaltase	Homo sapiens	251-253
15944403-9	2005	The characteristics of this motif are three phenylalanine residues that upon substitution by alanine generate the temperature-sensitive SI(Q1098P) phenotype.	Phenylalanine	44-57	sucrase-isomaltase	Homo sapiens	136-138
15944403-9	2005	The characteristics of this motif are three phenylalanine residues that upon substitution by alanine generate the temperature-sensitive SI(Q1098P) phenotype.	Alanine	50-57	sucrase-isomaltase	Homo sapiens	136-138
15944403-12	2005	We propose that the phenylalanine cluster is required for shielding a folding determinant in the extracellular domain of SI; substitution of a Q by a P at residue 1098 of sucrase disrupts this determinant and elicits retention of SI(Q1098P) in ERGIC and cis-Golgi in phenotype II of CSID.	Phenylalanine	20-33	sucrase-isomaltase	Homo sapiens	121-123
16198577-1	2006	Three analogs (5, 6, and 7) lacking polar substituents in the side chain of a naturally occurring alpha-glucosidase inhibitor, salacinol (1a), were synthesized by the coupling reaction of a thiosugar, 1,4-dideoxy-1,4-epithio-D-arabinitol (3), with cyclic sulfates (8, 9, and 10), and their alpha-glucosidase inhibitory activities were examined.	salacinol	127-136	sucrase-isomaltase	Homo sapiens	98-115
16457643-0	2006	Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors.	voglibose	0-9	sucrase-isomaltase	Homo sapiens	53-70
16457643-0	2006	Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors.	voglibose	11-16	sucrase-isomaltase	Homo sapiens	53-70
16457643-0	2006	Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors.	AO 128	18-24	sucrase-isomaltase	Homo sapiens	53-70
16457643-2	2006	Voglibose, one of the most important alpha-glucosidase inhibitors, delays the digestion and absorption of carbohydrates, thereby inhibiting postprandial hyperglycemia and hyperinsulinemia, and is the aid in the treatment of diabetes.	voglibose	0-9	sucrase-isomaltase	Homo sapiens	37-54
16457643-2	2006	Voglibose, one of the most important alpha-glucosidase inhibitors, delays the digestion and absorption of carbohydrates, thereby inhibiting postprandial hyperglycemia and hyperinsulinemia, and is the aid in the treatment of diabetes.	Carbohydrates	106-119	sucrase-isomaltase	Homo sapiens	37-54
16202584-0	2005	Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors.	Sulfonamides	0-11	sucrase-isomaltase	Homo sapiens	39-56
16202584-0	2005	Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors.	Chalcone	12-20	sucrase-isomaltase	Homo sapiens	39-56
16202584-2	2005	Non-aminochalcones 1-12 had no inhibitory activity, however, aminochalcones 13-20 had strong glycosidase (alpha-glucosidase, alpha-amylase, and beta-amylase) inhibitory activities.	aminochalcones 13-20	61-81	sucrase-isomaltase	Homo sapiens	106-123
16202584-3	2005	In particular, sulfonamide chalcones 17-20 had more potent alpha-glucosidase inhibitory activity than aminated chalcone 13-16.	Sulfonamides	15-26	sucrase-isomaltase	Homo sapiens	59-76
16202584-3	2005	In particular, sulfonamide chalcones 17-20 had more potent alpha-glucosidase inhibitory activity than aminated chalcone 13-16.	Chalcones	27-36	sucrase-isomaltase	Homo sapiens	59-76
16202584-3	2005	In particular, sulfonamide chalcones 17-20 had more potent alpha-glucosidase inhibitory activity than aminated chalcone 13-16.	Chalcone	27-35	sucrase-isomaltase	Homo sapiens	59-76
16202584-4	2005	4"-(p-Toluenesulfonamide)-3,4-dihydroxy chalcone 20 (IC(50)=0.4microM) was the best inhibitor against alpha-glucosidase, and these sulfonamide chalcones showed non-competitive inhibition.	4"-(p-toluenesulfonamide)-3,4-dihydroxy chalcone	0-48	sucrase-isomaltase	Homo sapiens	102-119
16202584-4	2005	4"-(p-Toluenesulfonamide)-3,4-dihydroxy chalcone 20 (IC(50)=0.4microM) was the best inhibitor against alpha-glucosidase, and these sulfonamide chalcones showed non-competitive inhibition.	sulfonamide chalcones	131-152	sucrase-isomaltase	Homo sapiens	102-119
16542023-2	2005	Thus, inhibition of intestinal alpha-glucosidases can be used to treat diabetes through the lowering of blood glucose levels, and alpha-glucosidase inhibitors are being marketed against type 2 (non-insulinodependent mellitus) diabetes (i.e.: Glyset or Diastabol, Basen and Glucor or Precose).	Glucose	110-117	sucrase-isomaltase	Homo sapiens	31-48
15901356-7	2005	beta-glucosidase or beta-galactosidase (lactase/phloridzin hydrolase, LPH) and alpha-glucosidase (sucrase-isomaltase) had different pH-dependent activities for disaccharide conjugates.	Disaccharides	160-172	sucrase-isomaltase	Homo sapiens	98-116
15787675-0	2005	alpha-Glucosidase inhibition (acarbose) fails to enhance secretion of glucagon-like peptide 1 (7-36 amide) and to delay gastric emptying in Type 2 diabetic patients.	Acarbose	30-38	sucrase-isomaltase	Homo sapiens	0-17
15846673-1	2005	BACKGROUND: Alpha-glucosidase inhibitors such as acarbose or miglitol, have the potential to improve glycemic control in type 2 diabetes mellitus.	Acarbose	49-57	sucrase-isomaltase	Homo sapiens	12-29
15846673-1	2005	BACKGROUND: Alpha-glucosidase inhibitors such as acarbose or miglitol, have the potential to improve glycemic control in type 2 diabetes mellitus.	miglitol	61-69	sucrase-isomaltase	Homo sapiens	12-29
15973488-0	2005	Synthesis of hydroquinone-alpha-glucoside by alpha-glucosidase from baker"s yeast.	hydroquinoneglucoside	13-41	sucrase-isomaltase	Homo sapiens	45-62
15973488-1	2005	Hydroquinone-alpha-glucoside was synthesised from hydroquinone and maltose as glucosyl donor by transglucosylation in a water system with alpha-glucosidase from baker"s yeast.	hydroquinoneglucoside	0-28	sucrase-isomaltase	Homo sapiens	138-155
15973488-1	2005	Hydroquinone-alpha-glucoside was synthesised from hydroquinone and maltose as glucosyl donor by transglucosylation in a water system with alpha-glucosidase from baker"s yeast.	Maltose	67-74	sucrase-isomaltase	Homo sapiens	138-155
15973488-1	2005	Hydroquinone-alpha-glucoside was synthesised from hydroquinone and maltose as glucosyl donor by transglucosylation in a water system with alpha-glucosidase from baker"s yeast.	glucosyl	78-86	sucrase-isomaltase	Homo sapiens	138-155
15973488-1	2005	Hydroquinone-alpha-glucoside was synthesised from hydroquinone and maltose as glucosyl donor by transglucosylation in a water system with alpha-glucosidase from baker"s yeast.	Water	120-125	sucrase-isomaltase	Homo sapiens	138-155
16052375-2	2005	The detected activities (leucine aminopeptidase, beta-glucosidase, alpha-glucosidase, and beta-N-acetylglucosaminidase) were related to the available organic substrates (proteins and carbohydrates) and to the bacterial community (expressed in terms of abundance, biomass, and frequency of cell division).	Carbohydrates	183-196	sucrase-isomaltase	Homo sapiens	67-84
17191997-0	2005	Syntheses and biological activities of chalcone and 1,5-benzothiazepine derivatives: promising new free-radical scavengers, and esterase, urease, and alpha-glucosidase inhibitors.	Chalcone	39-47	sucrase-isomaltase	Homo sapiens	150-167
17191997-0	2005	Syntheses and biological activities of chalcone and 1,5-benzothiazepine derivatives: promising new free-radical scavengers, and esterase, urease, and alpha-glucosidase inhibitors.	1,5-benzothiazepine	52-71	sucrase-isomaltase	Homo sapiens	150-167
17191997-2	2005	Both the benzothiazepines and chalcones were evaluated as DPPH free-radical scavengers and as inhibitors of cholinesterases, urease, and alpha-glucosidase.	benzothiazepines	9-25	sucrase-isomaltase	Homo sapiens	137-154
17191997-2	2005	Both the benzothiazepines and chalcones were evaluated as DPPH free-radical scavengers and as inhibitors of cholinesterases, urease, and alpha-glucosidase.	Chalcones	30-39	sucrase-isomaltase	Homo sapiens	137-154
15698784-0	2005	alpha-Glucosidase inhibition of 6-hydroxyflavones.	6-hydroxyflavone	32-49	sucrase-isomaltase	Homo sapiens	0-17
15698784-6	2005	This is the first report on mammalian intestinal alpha-glucosidase inhibitory activity of 6-aminoflavones.	6-aminoflavones	90-105	sucrase-isomaltase	Homo sapiens	49-66
15671153-0	2005	Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury: prevention by the alpha-glucosidase inhibitor acarbose.	Acarbose	131-139	sucrase-isomaltase	Homo sapiens	103-120
15671153-1	2005	Protective effects of the alpha-glucosidase inhibitor acarbose have been reported for various diabetic complications.	Acarbose	54-62	sucrase-isomaltase	Homo sapiens	26-43
15671153-11	2005	This effect can be prevented by treatment with the alpha-glucosidase inhibitor acarbose.	Acarbose	79-87	sucrase-isomaltase	Homo sapiens	51-68
15771446-3	2005	Although d-DNJ and d-galacto-DNJ are known to be powerful competitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the nM range, l-DNJ and l-galacto-DNJ were noncompetitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the muM range.	1-Deoxynojirimycin	9-14	sucrase-isomaltase	Homo sapiens	84-101
15771446-3	2005	Although d-DNJ and d-galacto-DNJ are known to be powerful competitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the nM range, l-DNJ and l-galacto-DNJ were noncompetitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the muM range.	1-Deoxynojirimycin	9-14	sucrase-isomaltase	Homo sapiens	233-250
15771446-3	2005	Although d-DNJ and d-galacto-DNJ are known to be powerful competitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the nM range, l-DNJ and l-galacto-DNJ were noncompetitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the muM range.	D-galacto-1-deoxynojirimycin	19-32	sucrase-isomaltase	Homo sapiens	84-101
15771446-3	2005	Although d-DNJ and d-galacto-DNJ are known to be powerful competitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the nM range, l-DNJ and l-galacto-DNJ were noncompetitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the muM range.	D-galacto-1-deoxynojirimycin	19-32	sucrase-isomaltase	Homo sapiens	233-250
15771446-17	2005	d-galacto-DNJ is a potent inhibitor of lysosomal alpha-galactosidase (IC(50) = 90 nM) and is now being evaluated preclinically for its potential use in Fabry disease, while d-DNJ inhibiting alpha-glucosidase (IC(50) = 40 nM) potently does not appear to become a potential therapeutic agent because of additional inhibitory activity toward glycoprotein processing alpha-glucosidases.	D-galacto-1-deoxynojirimycin	0-13	sucrase-isomaltase	Homo sapiens	190-207
15713383-5	2005	Some of the compounds, 2a, 3a and b and 4 displayed better alpha-glucosidase inhibitory activity compared to standard drug acarbose.	Acarbose	123-131	sucrase-isomaltase	Homo sapiens	59-76
15698784-7	2005	Kinetic studies revealed that 16 inhibited both sucrose- and maltose-hydrolyzing activities of rat intestinal alpha-glucosidase uncompetitively.	Sucrose	48-55	sucrase-isomaltase	Homo sapiens	110-127
15698784-7	2005	Kinetic studies revealed that 16 inhibited both sucrose- and maltose-hydrolyzing activities of rat intestinal alpha-glucosidase uncompetitively.	Maltose	61-68	sucrase-isomaltase	Homo sapiens	110-127
15698784-1	2005	Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as alpha-glucosidase inhibitors.	2,3,4-trihydroxybenzoyl-	36-60	sucrase-isomaltase	Homo sapiens	112-129
15698784-1	2005	Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as alpha-glucosidase inhibitors.	Flavonoids	71-80	sucrase-isomaltase	Homo sapiens	112-129
15698784-1	2005	Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as alpha-glucosidase inhibitors.	6-aminoflavones	93-108	sucrase-isomaltase	Homo sapiens	112-129
15698784-4	2005	The results indicated that 5,6,7-trihydroxy-2-phenyl-4-quinolone (2) and 5,6,7-trihydroxyflavanone (4) showed the comparable activity to 1, while 3,5,6,7-tetrahydroxyflavone (7), 5,6,7-trihydroxyisoflavone (8), and 6-hydroxygenistein (9) showed moderate alpha-glucosidase inhibitory activity.	5,6,7-trihydroxy-2-phenyl-4-quinolone	27-64	sucrase-isomaltase	Homo sapiens	254-271
15698784-4	2005	The results indicated that 5,6,7-trihydroxy-2-phenyl-4-quinolone (2) and 5,6,7-trihydroxyflavanone (4) showed the comparable activity to 1, while 3,5,6,7-tetrahydroxyflavone (7), 5,6,7-trihydroxyisoflavone (8), and 6-hydroxygenistein (9) showed moderate alpha-glucosidase inhibitory activity.	Dihydrobaicalein	73-98	sucrase-isomaltase	Homo sapiens	254-271
15698784-5	2005	In addition, it was found that 6-amino-5,7-dihydroxyflavone (16) was a more potent and specific rat intestinal alpha-glucosidase inhibitor than 1, and showed the comparable activity to acarbose.	6-amino-5,7-dihydroxyflavone	31-59	sucrase-isomaltase	Homo sapiens	111-128
15813654-8	2005	The alpha-glucosidase inhibitors delay intestinal absorption of ingested carbohydrates.	Carbohydrates	73-86	sucrase-isomaltase	Homo sapiens	4-21
15713352-1	2005	OBJECTIVE: An open randomized prospective study was performed to elucidate the effect of an alpha-glucosidase inhibitor, voglibose, on the progression of atherosclerosis in subjects with type 2 diabetes.	voglibose	121-130	sucrase-isomaltase	Homo sapiens	92-109
15736118-0	2005	Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms.	voglibose	44-53	sucrase-isomaltase	Homo sapiens	14-31
15736118-5	2005	When patients were divided according to subjective symptoms, however, the sum postprandial glucose increments were significantly different according to the agent (P = .03), with favorable efficacy in patients in whom the alpha-glucosidase inhibitor caused abdominal symptoms, demonstrating a significant interaction (P = .04) between treatment and symptomatic grouping.	Glucose	91-98	sucrase-isomaltase	Homo sapiens	221-238
15669880-6	2005	These main classes include agents that stimulate insulin secretion (sulphonylureas and rapid-acting secretagogues), reduce hepatic glucose production (biguanides), delay digestion and absorption of intestinal carbohydrate (alpha-glucosidase inhibitors) or improve insulin action (thiazolidinediones).	Carbohydrates	209-221	sucrase-isomaltase	Homo sapiens	223-240
15337448-4	2004	The side chain was chosen because it is present in a known sulfonium ion alpha-glucosidase inhibitor, salacinol.	salacinol	102-111	sucrase-isomaltase	Homo sapiens	73-90
15669880-6	2005	These main classes include agents that stimulate insulin secretion (sulphonylureas and rapid-acting secretagogues), reduce hepatic glucose production (biguanides), delay digestion and absorption of intestinal carbohydrate (alpha-glucosidase inhibitors) or improve insulin action (thiazolidinediones).	Thiazolidinediones	280-298	sucrase-isomaltase	Homo sapiens	223-240
16103719-5	2005	RESULTS: Treatment of skin slices with lignoceric acid significantly increased (p &lt; 0.001) the enzymic activities of acid lipase, acid phosphatase, alpha-glucosidase, alpha-galactosidase, N-acetyl-alpha-D-glucosaminidase (NAGA) and N-acetyl-alpha-D-galactosaminidase (NAGTA).	lignoceric acid	39-54	sucrase-isomaltase	Homo sapiens	151-168
16103719-6	2005	ATZ (1-5 mM), an inhibitor of key peroxi somal enzyme catalase, also markedly increased the enzymic activities of acid phosphatase, alpha-glucosidase (23%) and alpha-galactosidase (18%) without any significant effect on NAGA or NAGTA.	Amitrole	0-3	sucrase-isomaltase	Homo sapiens	132-149
15213063-3	2004	We tested the role of glucose toxicity in age-related beta-cell dysfunction in older people (65 +/- 8 yr) with IGT treated with the alpha-glucosidase inhibitor acarbose (n = 14) or placebo (n = 13) for 6 wk in a randomized, double-blind study.	Acarbose	160-168	sucrase-isomaltase	Homo sapiens	132-149
15531188-7	2004	The most recent addition, glimepiride, can be used in combination with metformin, the thiazolidinediones, alpha-glucosidase inhibitors, and insulin.	glimepiride	26-37	sucrase-isomaltase	Homo sapiens	106-123
15474008-0	2004	Synergetic inhibition of metal ions and genistein on alpha-glucosidase.	Metals	25-30	sucrase-isomaltase	Homo sapiens	53-70
15474008-0	2004	Synergetic inhibition of metal ions and genistein on alpha-glucosidase.	Genistein	40-49	sucrase-isomaltase	Homo sapiens	53-70
15474008-1	2004	Inhibition of metal ions and synergetic inhibition of metal ions/genistein on alpha-glucosidase activity has been investigated.	Metals	54-59	sucrase-isomaltase	Homo sapiens	78-95
15474008-1	2004	Inhibition of metal ions and synergetic inhibition of metal ions/genistein on alpha-glucosidase activity has been investigated.	Genistein	65-74	sucrase-isomaltase	Homo sapiens	78-95
15474008-3	2004	The results show that the nature of the inhibition was reversible, slow-binding, non-competitive, and the Ki values of some ions such as Cu2+, Ni2+ and Zn2+ range from 10(-5) to 10(-6) M. Moreover, synergetic inhibitory effect of metal ions and genistein on alpha-glucosidase were studied with kinetics method.	cupric ion	137-141	sucrase-isomaltase	Homo sapiens	258-275
15474008-3	2004	The results show that the nature of the inhibition was reversible, slow-binding, non-competitive, and the Ki values of some ions such as Cu2+, Ni2+ and Zn2+ range from 10(-5) to 10(-6) M. Moreover, synergetic inhibitory effect of metal ions and genistein on alpha-glucosidase were studied with kinetics method.	Nickel(2+)	143-147	sucrase-isomaltase	Homo sapiens	258-275
15474008-3	2004	The results show that the nature of the inhibition was reversible, slow-binding, non-competitive, and the Ki values of some ions such as Cu2+, Ni2+ and Zn2+ range from 10(-5) to 10(-6) M. Moreover, synergetic inhibitory effect of metal ions and genistein on alpha-glucosidase were studied with kinetics method.	Zinc	152-156	sucrase-isomaltase	Homo sapiens	258-275
15474008-3	2004	The results show that the nature of the inhibition was reversible, slow-binding, non-competitive, and the Ki values of some ions such as Cu2+, Ni2+ and Zn2+ range from 10(-5) to 10(-6) M. Moreover, synergetic inhibitory effect of metal ions and genistein on alpha-glucosidase were studied with kinetics method.	Metals	230-235	sucrase-isomaltase	Homo sapiens	258-275
15474008-3	2004	The results show that the nature of the inhibition was reversible, slow-binding, non-competitive, and the Ki values of some ions such as Cu2+, Ni2+ and Zn2+ range from 10(-5) to 10(-6) M. Moreover, synergetic inhibitory effect of metal ions and genistein on alpha-glucosidase were studied with kinetics method.	Genistein	245-254	sucrase-isomaltase	Homo sapiens	258-275
15388960-0	2004	Importance of the B ring and its substitution on the alpha-glucosidase inhibitory activity of baicalein, 5,6,7-trihydroxyflavone.	baicalein	94-103	sucrase-isomaltase	Homo sapiens	53-70
15308227-5	2004	alpha-Glucosidase hydrolyses maltose to alpha-D-glucose, which is converted to beta-D-glucose by mutarotase.	Maltose	29-36	sucrase-isomaltase	Homo sapiens	0-17
15308227-5	2004	alpha-Glucosidase hydrolyses maltose to alpha-D-glucose, which is converted to beta-D-glucose by mutarotase.	alpha-D-glucose	40-55	sucrase-isomaltase	Homo sapiens	0-17
15308227-5	2004	alpha-Glucosidase hydrolyses maltose to alpha-D-glucose, which is converted to beta-D-glucose by mutarotase.	Zymosan	79-93	sucrase-isomaltase	Homo sapiens	0-17
15388960-0	2004	Importance of the B ring and its substitution on the alpha-glucosidase inhibitory activity of baicalein, 5,6,7-trihydroxyflavone.	baicalein	105-128	sucrase-isomaltase	Homo sapiens	53-70
15269621-1	2004	BACKGROUND: Starch digestion is dependent on a combination of pancreatic and salivary amylase and the intestinal brush border enzymes glucoamylase and sucrase-isomaltase.	Starch	12-18	sucrase-isomaltase	Homo sapiens	151-169
15313146-7	2004	The measurement of acid alpha-glucosidase activity with minimal interference by other alpha-glucosidases was accomplished using maltose as an inhibitor.	Maltose	128-135	sucrase-isomaltase	Homo sapiens	24-41
15332853-0	2004	Penasulfate A, a new alpha-glucosidase inhibitor from a marine sponge Penares sp.	penasulfate A	0-13	sucrase-isomaltase	Homo sapiens	21-38
15332853-1	2004	A new alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.	penasulfate A	35-48	sucrase-isomaltase	Homo sapiens	6-23
15332853-1	2004	A new alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.	TFF2 protein, human	82-84	sucrase-isomaltase	Homo sapiens	6-23
15340737-5	2004	Recently, the STOP-NIDDM trial has been shown that patients with impaired glucose tolerance treated with the alpha-glucosidase inhibitor acarbose had a significant reduction in the risk of cardiovascular disease.	Acarbose	137-145	sucrase-isomaltase	Homo sapiens	109-126
15125954-0	2004	Structure-activity relationships of trans-cinnamic acid derivatives on alpha-glucosidase inhibition.	cinnamic acid	36-55	sucrase-isomaltase	Homo sapiens	71-88
15203173-1	2004	The methanolic extract of rhizome of Himalayan rhubarb Rheum emodi displayed mild yeast as well as mammalian intestinal alpha-glucosidase inhibitory activity.	methanolic	4-14	sucrase-isomaltase	Homo sapiens	120-137
15203173-3	2004	Rhapontigenin, desoxyrhapontigenin, chrysophanol-8-O-beta-d-glucopyranoside, torachrysone-8-O-beta-d-glucopyranoside displayed potent yeast alpha-glucosidase inhibition.	rhapontigenin	0-13	sucrase-isomaltase	Homo sapiens	140-157
15203173-3	2004	Rhapontigenin, desoxyrhapontigenin, chrysophanol-8-O-beta-d-glucopyranoside, torachrysone-8-O-beta-d-glucopyranoside displayed potent yeast alpha-glucosidase inhibition.	3,5-dihydroxy-4'-methoxystilbene	15-34	sucrase-isomaltase	Homo sapiens	140-157
15203173-4	2004	However chrysophanol-8-O-beta-d-glucopyranoside, desoxyrhaponticin and torachrysone-8-O-beta-d-glucopyranoside displayed potent to moderate mammalian alpha-glucosidase inhibitory activity.	desoxyrhaponticin	49-66	sucrase-isomaltase	Homo sapiens	150-167
15203173-7	2004	Further kinetic analysis on mammalian alpha-glucosidase inhibition showed that chrysophanol-8-O-beta-d-glucopyranoside, desoxyrhaponticin and torachrysone-8-O-beta-d-glucopyranoside may be classified as mixed-noncompetitive inhibitors.	desoxyrhaponticin	120-137	sucrase-isomaltase	Homo sapiens	38-55
15203173-9	2004	Presence and position of glycoside moiety in compounds appear important for better inhibition of mammalian alpha-glucosidase.	Glycosides	25-34	sucrase-isomaltase	Homo sapiens	107-124
15125954-6	2004	These results indicated that trans-cinnamic acid derivatives could be classified as a new group of alpha-glucosidase inhibitors.	cinnamic acid	29-48	sucrase-isomaltase	Homo sapiens	99-116
15125965-0	2004	Synergetic inhibition of genistein and D-glucose on alpha-glucosidase.	Genistein	25-34	sucrase-isomaltase	Homo sapiens	52-69
15125965-0	2004	Synergetic inhibition of genistein and D-glucose on alpha-glucosidase.	Glucose	39-48	sucrase-isomaltase	Homo sapiens	52-69
15125954-1	2004	trans-Cinnamic acid and its derivatives were investigated for the alpha-glucosidase inhibitory activity.	cinnamic acid	0-19	sucrase-isomaltase	Homo sapiens	66-83
15125954-3	2004	The presence of substituents at 4-position in trans-cinnamic acid altered the alpha-glucosidase inhibitory activity.	cinnamic acid	46-65	sucrase-isomaltase	Homo sapiens	78-95
15125965-1	2004	Synergetic inhibitory effect of genistein (I2) and D-glucose (I1) on alpha-glucosidase has been studied with kinetics method.	Genistein	32-41	sucrase-isomaltase	Homo sapiens	69-86
15125954-5	2004	4-Methoxy-trans-cinnamic acid was a noncompetitive inhibitor for alpha-glucosidase, whereas, 4-methoxy-trans-cinnamic acid ethyl ester was a competitive inhibitor.	4-methoxy-trans-cinnamic acid	0-29	sucrase-isomaltase	Homo sapiens	65-82
15125965-1	2004	Synergetic inhibitory effect of genistein (I2) and D-glucose (I1) on alpha-glucosidase has been studied with kinetics method.	Glucose	51-60	sucrase-isomaltase	Homo sapiens	69-86
15266896-0	2004	Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Alpha-glucosidase I inhibitors have been shown to inhibit the replication of a broad range of enveloped viruses by preventing the correct folding of their envelope glycoproteins.	celgosivir	10-20	sucrase-isomaltase	Homo sapiens	128-145
15266896-0	2004	Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Alpha-glucosidase I inhibitors have been shown to inhibit the replication of a broad range of enveloped viruses by preventing the correct folding of their envelope glycoproteins.	celgosivir	22-50	sucrase-isomaltase	Homo sapiens	128-145
15266896-4	2004	Of the alpha-glucosidase inhibitors tested, only N-nonyl DNJ showed evidence of toxicity (CC50 &gt; or = 120 microM).	n-nonyl dnj	49-60	sucrase-isomaltase	Homo sapiens	7-24
15266896-6	2004	The observation that the number of viral genomes released from BVDV-infected cells was inhibited by either castanospermine or celgosivir in parallel with the number of infectious units was taken as confirmation that these alpha-glucosidase I inhibitors block the production or release of flavivirus particles.	castanospermine	107-122	sucrase-isomaltase	Homo sapiens	222-239
15266896-6	2004	The observation that the number of viral genomes released from BVDV-infected cells was inhibited by either castanospermine or celgosivir in parallel with the number of infectious units was taken as confirmation that these alpha-glucosidase I inhibitors block the production or release of flavivirus particles.	celgosivir	126-136	sucrase-isomaltase	Homo sapiens	222-239
14683737-1	2004	AIMS: To assess if treatment with the alpha-glucosidase inhibitor acarbose can reduce cardiovascular events in type 2 diabetic patients.	Acarbose	66-74	sucrase-isomaltase	Homo sapiens	38-55
15145332-0	2004	Different effects of two alpha-glucosidase inhibitors, acarbose and voglibose, on serum 1,5-anhydroglucitol (1,5AG) level.	1,5-anhydroglucitol	88-107	sucrase-isomaltase	Homo sapiens	25-42
15145332-1	2004	Serum 1,5-anhydroglucitol (1,5AG) is a useful glycemic marker in the control of diabetes; however, treated with alpha-glucosidase inhibitors (alpha-GIs), acarbose (Aca) and voglibose (Vog), it tends to show the discrepancy between serum 1,5AG and related glucose levels.	1,5-anhydroglucitol	6-25	sucrase-isomaltase	Homo sapiens	112-129
15145332-1	2004	Serum 1,5-anhydroglucitol (1,5AG) is a useful glycemic marker in the control of diabetes; however, treated with alpha-glucosidase inhibitors (alpha-GIs), acarbose (Aca) and voglibose (Vog), it tends to show the discrepancy between serum 1,5AG and related glucose levels.	1,5-anhydroglucitol	27-32	sucrase-isomaltase	Homo sapiens	112-129
15088751-3	2004	Spectral analysis revealed that A was the alpha-glucosidase inhibitor amylostatin XG.	acarviosine-glucose	70-84	sucrase-isomaltase	Homo sapiens	42-59
14669056-0	2004	Biotechnology and molecular biology of the alpha-glucosidase inhibitor acarbose.	Acarbose	71-79	sucrase-isomaltase	Homo sapiens	43-60
15073402-2	2004	Acarbose, an alpha-glucosidase inhibitor, was shown in the placebo-controlled prospective study to prevent noninsulin-dependent diabetes mellitus (STOP-NIDDM) trial to reduce the risk of diabetes by 36% in IGT subjects.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
15182036-8	2004	Acarbose, a specific inhibitor of gut alpha-glucosidase enzymes, may be helpful in case of diet failure.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	38-55
15019860-4	2004	Secretagogues and alpha-glucosidase inhibitors effectively lower plasma glucose levels only, whereas insulin sensitizers reduce several important cardiac risk factors in addition to reducing plasma glucose levels.	Glucose	72-79	sucrase-isomaltase	Homo sapiens	18-35
14709083-0	2004	Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei.	schulzeines a-c	0-15	sucrase-isomaltase	Homo sapiens	21-38
14709083-1	2004	Three new alpha-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei.	schulzeines a-c	40-55	sucrase-isomaltase	Homo sapiens	10-27
14709083-4	2004	Schulzeines A-C inhibit alpha-glucosidase with IC(50) values of 48-170 nM.	schulzeines a-c	0-15	sucrase-isomaltase	Homo sapiens	24-41
12819930-13	2003	Hypothetical target events/molecules of thalidomide include tumor necrosis factor-alpha production, nuclear androgen receptor, cyclooxygenases, aminopeptidases, and alpha-glucosidase.	Thalidomide	40-51	sucrase-isomaltase	Homo sapiens	165-182
14724820-1	2003	BACKGROUND &amp; AIMS: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive human disorder characterized by reduced activities of the brush border enzyme sucrase-isomaltase (SI).	Adenosine Monophosphate	12-15	sucrase-isomaltase	Homo sapiens	34-52
14703948-1	2003	Acarbose--the most extensively investigated and widely prescribed alpha-glucosidase inhibitor--reduces postprandial plasma glucose excursions by delaying the absorption of carbohydrate from the small intestine.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	66-83
14703948-1	2003	Acarbose--the most extensively investigated and widely prescribed alpha-glucosidase inhibitor--reduces postprandial plasma glucose excursions by delaying the absorption of carbohydrate from the small intestine.	Glucose	123-130	sucrase-isomaltase	Homo sapiens	66-83
14692324-0	2003	[Study on the inhibition of alpha-glucosidase by soyasaponins].	soyasaponins	49-61	sucrase-isomaltase	Homo sapiens	28-45
14692324-1	2003	OBJECTIVE: To study the inhibitory effects of soyasaponins on alpha-glucosidase (EC3.2.1.20).	soyasaponins	46-58	sucrase-isomaltase	Homo sapiens	62-79
14692324-3	2003	The inhibitory activities of each component of soyasaponins against alpha-glucosidase were tested by colorimetric method.	soyasaponins	47-59	sucrase-isomaltase	Homo sapiens	68-85
12951527-2	2003	At pH 4.7, acid phosphatase (pI, 5.4), alpha-glucosidase (pI, 5.7), and beta-glucosidase (pI, 7.3) were inhibited by APS to various extents.	aps	117-120	sucrase-isomaltase	Homo sapiens	39-56
12892501-2	2003	Two kinds of proteins, alpha-glucosidase and lysozyme, were covalently attached to dextran matrices on the sensor surface in the flow cell and then exposed to various concentrations of TX solution.	Dextrans	83-90	sucrase-isomaltase	Homo sapiens	23-40
12624791-3	2003	In alpha-glucosidase (acid maltase) deficiency (alphaGDD), accumulation of glycogen is accompanied by cytoarchitectural abnormalities impairing normal protein metabolism.	Glycogen	75-83	sucrase-isomaltase	Homo sapiens	3-20
12599258-7	2003	The rates of ectoenzyme-mediated polysaccharide (alpha-glucosidase) and protein (leucine aminopeptidase) hydrolysis became relatively constant once pollutant removal efficiency stabilized.	Polysaccharides	33-47	sucrase-isomaltase	Homo sapiens	49-66
12775461-10	2003	It is concluded that formate, propionate and butyrate selectively and differentially modulate growth characteristics, cellular metabolism, sucrase isomaltase activity and transepithelial electrical resistance in a concentration- and carbon atom-related fashion.	formic acid	21-28	sucrase-isomaltase	Homo sapiens	139-157
12775461-10	2003	It is concluded that formate, propionate and butyrate selectively and differentially modulate growth characteristics, cellular metabolism, sucrase isomaltase activity and transepithelial electrical resistance in a concentration- and carbon atom-related fashion.	Propionates	30-40	sucrase-isomaltase	Homo sapiens	139-157
12775461-10	2003	It is concluded that formate, propionate and butyrate selectively and differentially modulate growth characteristics, cellular metabolism, sucrase isomaltase activity and transepithelial electrical resistance in a concentration- and carbon atom-related fashion.	Butyrates	45-53	sucrase-isomaltase	Homo sapiens	139-157
12948306-5	2003	Acarbose, an alpha-glucosidase inhibitor, has been used sporadically in adults after gastric surgery, but only once in children.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
12676094-3	2003	The two intestinal proteins lactase-phlorizin hydrolase (LPH) and sucrase-isomaltase (SI) are delivered to the apical plasma membrane of epithelial cells with high fidelity but differ in their affinity to detergent-insoluble, glycolipid-enriched complexes (DIGs).	Glycolipids	226-236	sucrase-isomaltase	Homo sapiens	66-84
12676094-3	2003	The two intestinal proteins lactase-phlorizin hydrolase (LPH) and sucrase-isomaltase (SI) are delivered to the apical plasma membrane of epithelial cells with high fidelity but differ in their affinity to detergent-insoluble, glycolipid-enriched complexes (DIGs).	digs	257-261	sucrase-isomaltase	Homo sapiens	66-84
12547908-2	2003	Brush-border sucrase-isomaltase (SI) activity is complementary, through digestion of branched starch linkages.	Starch	94-100	sucrase-isomaltase	Homo sapiens	13-31
12542726-12	2003	CONCLUSION: Pioglitazone was considered to be effective when used in patients whose type 2 diabetes were poorly controlled with alpha-glucosidase inhibitor alone or alpha-glucosidase in combination with sulfonylurea.	Pioglitazone	12-24	sucrase-isomaltase	Homo sapiens	128-145
12926248-1	2003	In order to investigate the hypothesis that the glycosidase inhibitor isofagomine was bound to alpha- or beta-glucosidase in a 1,4B conformation, a number of bicyclic aziridines that adopt the 1,4B or B1,4 conformations were synthesised and investigated.	isofagomine	70-81	sucrase-isomaltase	Homo sapiens	95-121
14606987-8	2003	The insulin sensitizer metformin, on the other hand, does not affect PPG levels, whereas the alpha-glucosidase inhibitors, in the presence of a high-carbohydrate diet, can effectively lower PPG.	Carbohydrates	149-161	sucrase-isomaltase	Homo sapiens	93-110
14606987-8	2003	The insulin sensitizer metformin, on the other hand, does not affect PPG levels, whereas the alpha-glucosidase inhibitors, in the presence of a high-carbohydrate diet, can effectively lower PPG.	ppg	190-193	sucrase-isomaltase	Homo sapiens	93-110
12542726-0	2003	Clinical evaluation of pioglitazone in patients with type 2 diabetes using alpha-glucosidase inhibitor and examination of its efficacy profile.	Pioglitazone	23-35	sucrase-isomaltase	Homo sapiens	75-92
12542726-12	2003	CONCLUSION: Pioglitazone was considered to be effective when used in patients whose type 2 diabetes were poorly controlled with alpha-glucosidase inhibitor alone or alpha-glucosidase in combination with sulfonylurea.	Pioglitazone	12-24	sucrase-isomaltase	Homo sapiens	165-182
12542726-2	2003	This study was conducted to evaluate the efficacy, safety and clinical profile of pioglitazone in patients whose type 2 diabetes were poorly controlled with alpha-glucosidase inhibitor alone or alpha-glucosidase in combination with sulfonylurea.	Pioglitazone	82-94	sucrase-isomaltase	Homo sapiens	157-174
12542726-2	2003	This study was conducted to evaluate the efficacy, safety and clinical profile of pioglitazone in patients whose type 2 diabetes were poorly controlled with alpha-glucosidase inhibitor alone or alpha-glucosidase in combination with sulfonylurea.	Pioglitazone	82-94	sucrase-isomaltase	Homo sapiens	194-211
12520825-7	2002	Alpha-glucosidase inhibitors delay the digestion and absorption of polysaccharides, thus attenuating postprandial hyperglycaemia.	Polysaccharides	67-82	sucrase-isomaltase	Homo sapiens	0-17
14530603-2	2003	Acarbose, an alpha-glucosidase inhibitor, decreases the absorbed glucose load.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
14530603-2	2003	Acarbose, an alpha-glucosidase inhibitor, decreases the absorbed glucose load.	Glucose	65-72	sucrase-isomaltase	Homo sapiens	13-30
12502081-0	2002	A novel method for the assay of alpha-glucosidase inhibitory activity using a multi-channel oxygen sensor.	Oxygen	92-98	sucrase-isomaltase	Homo sapiens	32-49
12489381-3	2002	Meglitinides and phenylalanine derivatives and alpha-glucosidase inhibitors may be useful for elderly patients and others with normal fasting blood glucose levels and postprandial hyperglycemia, but they are less effective in achieving goal HbA1c levels in patients with marked fasting hyperglycemia.	Glucose	148-155	sucrase-isomaltase	Homo sapiens	47-64
12489066-1	2002	The aim of this study was to investigate whether combination therapy of alpha-glucosidase inhibitor and a sulfonylurea (SU) drug can prolong the duration of good glycemic control compared with SU alone in patients with type 2 diabetes.	Sulfonylurea Compounds	193-195	sucrase-isomaltase	Homo sapiens	72-89
12506981-0	2002	Purification and characterization of a novel fungal alpha-glucosidase from Mortierella alliacea with high starch-hydrolytic activity.	Starch	106-112	sucrase-isomaltase	Homo sapiens	52-69
12506981-2	2002	Here, a alpha-glucosidase responsible for the starch hydrolysis was purified from the culture broth through four-step column chromatography.	Starch	46-52	sucrase-isomaltase	Homo sapiens	8-25
12506981-3	2002	Maltose and other oligosaccharides were less preferentially hydrolyzed and were used as a glucosyl donor for transglucosylation by the enzyme, demonstrating distinct substrate specificity as a fungal alpha-glucosidase.	Maltose	0-7	sucrase-isomaltase	Homo sapiens	200-217
12506981-3	2002	Maltose and other oligosaccharides were less preferentially hydrolyzed and were used as a glucosyl donor for transglucosylation by the enzyme, demonstrating distinct substrate specificity as a fungal alpha-glucosidase.	Oligosaccharides	18-34	sucrase-isomaltase	Homo sapiens	200-217
12502284-1	2002	The in vivo and in vitro effects of 4-amino-3-(D-glucopentitol-1-yl)-5-mercapto-1,2,4-triazole and its 3-methyl analogue on alpha- and beta-glucosidases, beta-glucuronidase as well as alpha-amylase have been investigated.	4-amino-3-(d-glucopentitol-1-yl)-5-mercapto-1,2,4-triazole	36-94	sucrase-isomaltase	Homo sapiens	124-152
12390089-9	2002	Multivariate analysis showed that the basal serum testosterone level was the only variable in predicting the probability of response to the clomiphene in terms of true-corrected seminal fructose, seminal acid phosphatase and seminal alpha-glucosidase levels.	Testosterone	50-62	sucrase-isomaltase	Homo sapiens	233-250
12390089-9	2002	Multivariate analysis showed that the basal serum testosterone level was the only variable in predicting the probability of response to the clomiphene in terms of true-corrected seminal fructose, seminal acid phosphatase and seminal alpha-glucosidase levels.	Clomiphene	140-150	sucrase-isomaltase	Homo sapiens	233-250
12390089-11	2002	However, a high response in terms of seminal acid phosphatase (P &lt; 0.004) or alpha-glucosidase (P &lt; 0.037) was observed in men with low basal serum testosterone levels.	Testosterone	154-166	sucrase-isomaltase	Homo sapiens	80-97
12470267-0	2002	Identification of novel alpha-glucosidase inhibitors by screening libraries based on N- [4-(benzyloxy) benzoyl] alanine derivatives.	n- [4-(benzyloxy) benzoyl] alanine	85-119	sucrase-isomaltase	Homo sapiens	24-41
12470267-1	2002	A library of 72 compounds related to N- [4-(benzyloxy) benzoyl]alanine (I) was synthesized, prepared and screened for alpha-glucosidase inhibitory activity.	n- [4-(benzyloxy) benzoyl]alanine	37-70	sucrase-isomaltase	Homo sapiens	118-135
12470267-3	2002	One compound, N- [4-(benzyloxy) benzoyl] serine, was found to be a potent inhibitor of alpha-glucosidase with 100% inhibition at 1 micro M. This inhibitor was at least five times more potent than the lead compound I.	n- [4-(benzyloxy) benzoyl] serine	14-47	sucrase-isomaltase	Homo sapiens	87-104
12231078-7	2002	A number of oral hypoglycemic agents, including thiazolidinediones, biguanides, sulfonylureas, and alpha-glucosidase inhibitors, may be used to normalize glucose levels in patients with type 2 diabetes.	Glucose	154-161	sucrase-isomaltase	Homo sapiens	99-116
12190996-1	2002	BACKGROUND: Previous studies reported that administration of first generation alpha-glucosidase inhibitors (AGIs), such as voglibose or acarbose, produced exaggerated and sustained postprandial responses of glucagon-like peptide-1 (GLP-1), an incretin hormone from the enteroinsular axis, in healthy humans.	voglibose	123-132	sucrase-isomaltase	Homo sapiens	78-95
12190996-1	2002	BACKGROUND: Previous studies reported that administration of first generation alpha-glucosidase inhibitors (AGIs), such as voglibose or acarbose, produced exaggerated and sustained postprandial responses of glucagon-like peptide-1 (GLP-1), an incretin hormone from the enteroinsular axis, in healthy humans.	Acarbose	136-144	sucrase-isomaltase	Homo sapiens	78-95
12088440-0	2002	Callyspongynic acid, a polyacetylenic acid which inhibits alpha-glucosidase, from the marine sponge Callyspongia truncata.	callyspongynic acid	0-19	sucrase-isomaltase	Homo sapiens	58-75
12173729-13	2002	CONCLUSIONS: The alpha-glucosidase inhibitor miglitol in Type 2 diabetic patients on diet alone decreases both HbA1c levels and postprandial glucose and insulin levels in a dose-dependent manner.	Glucose	141-148	sucrase-isomaltase	Homo sapiens	17-34
12088440-0	2002	Callyspongynic acid, a polyacetylenic acid which inhibits alpha-glucosidase, from the marine sponge Callyspongia truncata.	polyacetylenic acid	23-42	sucrase-isomaltase	Homo sapiens	58-75
12088440-1	2002	A new polyacetylenic acid, callyspongynic acid (1), was isolated as an alpha-glucosidase inhibitor from the marine sponge Callyspongia truncata.	polyacetylenic acid	6-25	sucrase-isomaltase	Homo sapiens	71-88
12088440-1	2002	A new polyacetylenic acid, callyspongynic acid (1), was isolated as an alpha-glucosidase inhibitor from the marine sponge Callyspongia truncata.	callyspongynic acid	27-46	sucrase-isomaltase	Homo sapiens	71-88
12073790-5	2002	Some hormones (amylin, glucagon-like peptide-1) can slow gastric emptying while alpha-glucosidase inhibitors (acarbose, miglitol) retard intestinal digestion and resorption of complex carbohydrates.	Carbohydrates	184-197	sucrase-isomaltase	Homo sapiens	80-97
12031449-0	2002	Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives.	Oleanolic Acid	35-49	sucrase-isomaltase	Homo sapiens	14-31
12031449-2	2002	All products showed a positive response only against alpha-glucosidase but not against the other enzymes; IC(50) calculations showed that the dihydroxy-olide derivative (4) was the most potent among all tested samples.	dihydroxy-olide	142-157	sucrase-isomaltase	Homo sapiens	53-70
12014995-1	2002	BACKGROUND: Disaccharide Intolerance Type I (Mendelian Interance in Man database: *222900) is a rare inborn error of metabolism resulting from mutation in sucrase-isomaltase (Enzyme Catalyzed 3.2.1.48).	Disaccharides	12-24	sucrase-isomaltase	Homo sapiens	155-173
11841810-0	2002	Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose.	Acarbose	56-64	sucrase-isomaltase	Homo sapiens	28-45
12005201-1	2002	The alpha-glucosidase inhibitor acarbose is a drug used to treat type II diabetes mellitus.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
11841810-0	2002	Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose.	dTDP-4-amino-4,6-dideoxy-glucose	92-132	sucrase-isomaltase	Homo sapiens	28-45
11818430-2	2002	Acarbose, an alpha-glucosidase inhibitor, has a beneficial role in controlling DM, although one of its side effects is diarrhea.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
11784150-8	2002	6-Acyl-AA-2G that is susceptible to enzymatic hydrolysis by tissue esterase and/or alpha-glucosidase produces AA-2G and AsA, which is in the skin tissues.	Ascorbic Acid	120-123	sucrase-isomaltase	Homo sapiens	83-100
11729638-6	2001	As for inhibitors of carbohydrate absorption, alpha-glucosidase inhibitors are now available as anti-diabetic drugs.	Carbohydrates	21-33	sucrase-isomaltase	Homo sapiens	46-63
11872380-3	2002	Three types of oral medications exert their antidiabetic action without directly stimulating insulin release: alpha-glucosidase inhibitors (e.g., acarbose) interfere with the digestion of dietary glucose precursors and the absorption of glucose; biguanides (e.g., metformin) inhibit hepatic gluconeogenesis, thereby lowering fasting blood glucose concentrations and increasing peripheral insulin sensitivity; and thiazolidinediones (e.g., rosiglitazone) improve the sensitivity of tissues to insulin-stimulated glucose disposal.	Acarbose	146-154	sucrase-isomaltase	Homo sapiens	110-127
11872380-3	2002	Three types of oral medications exert their antidiabetic action without directly stimulating insulin release: alpha-glucosidase inhibitors (e.g., acarbose) interfere with the digestion of dietary glucose precursors and the absorption of glucose; biguanides (e.g., metformin) inhibit hepatic gluconeogenesis, thereby lowering fasting blood glucose concentrations and increasing peripheral insulin sensitivity; and thiazolidinediones (e.g., rosiglitazone) improve the sensitivity of tissues to insulin-stimulated glucose disposal.	Glucose	196-203	sucrase-isomaltase	Homo sapiens	110-127
11872380-3	2002	Three types of oral medications exert their antidiabetic action without directly stimulating insulin release: alpha-glucosidase inhibitors (e.g., acarbose) interfere with the digestion of dietary glucose precursors and the absorption of glucose; biguanides (e.g., metformin) inhibit hepatic gluconeogenesis, thereby lowering fasting blood glucose concentrations and increasing peripheral insulin sensitivity; and thiazolidinediones (e.g., rosiglitazone) improve the sensitivity of tissues to insulin-stimulated glucose disposal.	Glucose	237-244	sucrase-isomaltase	Homo sapiens	110-127
11872380-3	2002	Three types of oral medications exert their antidiabetic action without directly stimulating insulin release: alpha-glucosidase inhibitors (e.g., acarbose) interfere with the digestion of dietary glucose precursors and the absorption of glucose; biguanides (e.g., metformin) inhibit hepatic gluconeogenesis, thereby lowering fasting blood glucose concentrations and increasing peripheral insulin sensitivity; and thiazolidinediones (e.g., rosiglitazone) improve the sensitivity of tissues to insulin-stimulated glucose disposal.	Glucose	237-244	sucrase-isomaltase	Homo sapiens	110-127
11872380-3	2002	Three types of oral medications exert their antidiabetic action without directly stimulating insulin release: alpha-glucosidase inhibitors (e.g., acarbose) interfere with the digestion of dietary glucose precursors and the absorption of glucose; biguanides (e.g., metformin) inhibit hepatic gluconeogenesis, thereby lowering fasting blood glucose concentrations and increasing peripheral insulin sensitivity; and thiazolidinediones (e.g., rosiglitazone) improve the sensitivity of tissues to insulin-stimulated glucose disposal.	Glucose	237-244	sucrase-isomaltase	Homo sapiens	110-127
15765626-8	2002	alpha-Glucosidase inhibitors like acarbose and miglitol attenuate the rate of absorption of sucrose by acting on the luminal enzymes.	Sucrose	92-99	sucrase-isomaltase	Homo sapiens	0-17
11576519-4	2001	The alpha-glucosidase inhibitors (acarbose, voglibose, miglitol) have been effective in delaying the digestion and absorption of carbohydrates, thus diminishing the postprandial surge in blood glucose levels without loss of calories.	Acarbose	34-42	sucrase-isomaltase	Homo sapiens	4-21
11509563-10	2001	The activity of malic dehydrogenase, alpha-glucosidase, and lactate dehydrogenase during their refolding from urea or guanidium hydrochloride denatured states increased significantly in presence of tubulin compared with that without tubulin.	Urea	110-114	sucrase-isomaltase	Homo sapiens	37-54
11509563-10	2001	The activity of malic dehydrogenase, alpha-glucosidase, and lactate dehydrogenase during their refolding from urea or guanidium hydrochloride denatured states increased significantly in presence of tubulin compared with that without tubulin.	guanidium hydrochloride	118-141	sucrase-isomaltase	Homo sapiens	37-54
11739896-6	2001	Two proteins comprising cysteine-containing polyionic fusion peptides, a modified Fab fragment and an alpha-glucosidase fusion, could be specifically conjugated by directed association and subsequent disulfide bond formation.	Cysteine	24-32	sucrase-isomaltase	Homo sapiens	102-119
11739896-6	2001	Two proteins comprising cysteine-containing polyionic fusion peptides, a modified Fab fragment and an alpha-glucosidase fusion, could be specifically conjugated by directed association and subsequent disulfide bond formation.	Disulfides	200-209	sucrase-isomaltase	Homo sapiens	102-119
11574493-0	2001	Clinical, endocrine and metabolic effects of acarbose, an alpha-glucosidase inhibitor, in PCOS patients with increased insulin response and normal glucose tolerance.	Acarbose	45-53	sucrase-isomaltase	Homo sapiens	58-75
11574493-1	2001	BACKGROUND: The aim of this study was to evaluate whether treatment with acarbose, an alpha-glucosidase inhibitor, improved hyperandrogenic symptoms, insulin and androgen serum concentrations in hyperinsulinaemic patients with polycystic ovary syndrome (PCOS).	Acarbose	73-81	sucrase-isomaltase	Homo sapiens	86-103
11576519-4	2001	The alpha-glucosidase inhibitors (acarbose, voglibose, miglitol) have been effective in delaying the digestion and absorption of carbohydrates, thus diminishing the postprandial surge in blood glucose levels without loss of calories.	voglibose	44-53	sucrase-isomaltase	Homo sapiens	4-21
11576519-4	2001	The alpha-glucosidase inhibitors (acarbose, voglibose, miglitol) have been effective in delaying the digestion and absorption of carbohydrates, thus diminishing the postprandial surge in blood glucose levels without loss of calories.	miglitol	55-63	sucrase-isomaltase	Homo sapiens	4-21
11576519-4	2001	The alpha-glucosidase inhibitors (acarbose, voglibose, miglitol) have been effective in delaying the digestion and absorption of carbohydrates, thus diminishing the postprandial surge in blood glucose levels without loss of calories.	Carbohydrates	129-142	sucrase-isomaltase	Homo sapiens	4-21
11576519-4	2001	The alpha-glucosidase inhibitors (acarbose, voglibose, miglitol) have been effective in delaying the digestion and absorption of carbohydrates, thus diminishing the postprandial surge in blood glucose levels without loss of calories.	Glucose	193-200	sucrase-isomaltase	Homo sapiens	4-21
11676026-2	2001	An alpha-amylase-added Caco-2 system was established as a useful model to evaluate the effects of alpha-glucosidase inhibitors on starch digestion.	Starch	130-136	sucrase-isomaltase	Homo sapiens	98-115
11566104-4	2001	Here, we investigate the different trafficking mechanisms of two apically sorted proteins, the DIG-associated sucrase-isomaltase (SI) and lactase-phlorizin hydrolase, which uses a DIG-independent pathway [5].	digitoxose	95-98	sucrase-isomaltase	Homo sapiens	110-128
11566104-4	2001	Here, we investigate the different trafficking mechanisms of two apically sorted proteins, the DIG-associated sucrase-isomaltase (SI) and lactase-phlorizin hydrolase, which uses a DIG-independent pathway [5].	digitoxose	95-98	sucrase-isomaltase	Homo sapiens	130-132
11566104-7	2001	A striking triangular pattern of concentration of the DIG-associated SI in subvesicular domains was observed.	digitoxose	54-57	sucrase-isomaltase	Homo sapiens	69-71
11473078-4	2001	RESULTS: The 12-month persistence rate for the OHA cohort was low, ranging from 31% for alpha-glucosidase inhibitors to 60% for metformin; compliance rates varied between 70 and 80%.	10-oxohexadecanoic acid	47-50	sucrase-isomaltase	Homo sapiens	88-105
11606172-1	2001	AIM: We evaluated the effects of an alpha-glucosidase inhibitor, acarbose, on glucose homoeostasis during postprandial exercise in Type 1 diabetic subjects.	Acarbose	65-73	sucrase-isomaltase	Homo sapiens	36-53
11457461-0	2001	Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor.	Genistein	0-9	sucrase-isomaltase	Homo sapiens	41-58
11481402-1	2001	Water-extracted Touchi, a traditional Chinese food, exerts a strong inhibitory activity against rat intestinal alpha-glucosidase in foodstuffs, and Touchi-extract (TE) has been shown to have an antihyperglycemic effect in rats and humans after a single oral administration.	Water	0-5	sucrase-isomaltase	Homo sapiens	111-128
11457461-0	2001	Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor.	Isoflavones	17-27	sucrase-isomaltase	Homo sapiens	41-58
11457461-3	2001	In the course of screening for useful alpha-glucosidase inhibitors, we isolated and identified genistein as a candidate for alpha-glucosidase inhibitor from fermentation broths of a Streptomyces sp.	Genistein	95-104	sucrase-isomaltase	Homo sapiens	38-55
11457461-3	2001	In the course of screening for useful alpha-glucosidase inhibitors, we isolated and identified genistein as a candidate for alpha-glucosidase inhibitor from fermentation broths of a Streptomyces sp.	Genistein	95-104	sucrase-isomaltase	Homo sapiens	124-141
11457461-4	2001	Genistein was shown to be a reversible, slow-binding, non-competitive inhibitor of yeast alpha-glucosidase with a K(i) value of 5.7x10(-8) M when the enzyme mixture was pretreated with genistein.	Genistein	0-9	sucrase-isomaltase	Homo sapiens	89-106
11457461-4	2001	Genistein was shown to be a reversible, slow-binding, non-competitive inhibitor of yeast alpha-glucosidase with a K(i) value of 5.7x10(-8) M when the enzyme mixture was pretreated with genistein.	Genistein	185-194	sucrase-isomaltase	Homo sapiens	89-106
11283019-6	2001	p38 MAPK activity dramatically increased as soon as Caco-2/15 cells reached confluence, whereas addition of SB203580 during differentiation of Caco-2/15 cells strongly attenuated sucrase-isomaltase gene and protein expression as well as protein expression of villin and alkaline phosphatase.	SB 203580	108-116	sucrase-isomaltase	Homo sapiens	179-197
11283019-7	2001	The binding of CDX2 to the sucrase-isomaltase promoter and its transcriptional activity were significantly reduced by SB203580.	SB 203580	118-126	sucrase-isomaltase	Homo sapiens	27-45
11411542-0	2001	Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.	4,5,6,7-tetrachlorophthalimide	36-66	sucrase-isomaltase	Homo sapiens	0-17
11411542-0	2001	Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.	cycloalkyl or	93-106	sucrase-isomaltase	Homo sapiens	0-17
11411542-0	2001	Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.	dicarba-closo-dodecaborane	107-133	sucrase-isomaltase	Homo sapiens	0-17
11411542-1	2001	Previous studies of alpha-glucosidase inhibitors derived from thalidomide revealed that 4,5,6,7-tetrachloro-N-alkylphthalimide derivatives are superior lead compounds.	Thalidomide	62-73	sucrase-isomaltase	Homo sapiens	20-37
11411542-1	2001	Previous studies of alpha-glucosidase inhibitors derived from thalidomide revealed that 4,5,6,7-tetrachloro-N-alkylphthalimide derivatives are superior lead compounds.	4,5,6,7-tetrachloro-n-alkylphthalimide	88-126	sucrase-isomaltase	Homo sapiens	20-37
11516639-1	2001	The water-extracted Touchi, a traditional Chinese food, exerted a strong inhibitory activity against rat intestinal alpha-glucosidase in foodstuffs.	Water	4-9	sucrase-isomaltase	Homo sapiens	116-133
11298744-6	2001	The carboxyl group (-COOH) of the Asp647 residue was for the first time shown to be the most likely proton donor acting as the acid catalyst in the alpha-glucosidase of family II.	Carbonic Acid	21-25	sucrase-isomaltase	Homo sapiens	148-165
11322845-1	2001	BACKGROUND: A carbose is the first of a new class of antidiabetic agents, the alpha-glucosidase inhibitors.	Carboxymethylcellulose Sodium	14-21	sucrase-isomaltase	Homo sapiens	78-95
11388491-0	2001	Co-existing proteins interfere with the action of nordihydroguaiaretic acid on retrograde Golgi-to-ER protein trafficking in NRK cells and alpha-glucosidase reaction in vitro.	Masoprocol	50-75	sucrase-isomaltase	Homo sapiens	139-156
11388491-1	2001	Induction of retrograde trafficking of mannosidase II and TGN38 in NRK cells and inhibition of alpha-glucosidase in vitro by nordihydroguaiaretic acid (NDGA) were strongly interfered with by serum, serum albumin, or other unrelated proteins added to the medium or incubation mixture.	Masoprocol	125-150	sucrase-isomaltase	Homo sapiens	95-112
11388491-1	2001	Induction of retrograde trafficking of mannosidase II and TGN38 in NRK cells and inhibition of alpha-glucosidase in vitro by nordihydroguaiaretic acid (NDGA) were strongly interfered with by serum, serum albumin, or other unrelated proteins added to the medium or incubation mixture.	Masoprocol	152-156	sucrase-isomaltase	Homo sapiens	95-112
11358685-9	2001	For the treatment of PPH in diabetic patients, our experience suggests that it may be appropriate to try first on alpha-glucosidase inhibitor like acarbose.	Acarbose	147-155	sucrase-isomaltase	Homo sapiens	114-131
11098345-1	2000	OBJECTIVE: To evaluate miglitol, a new oral alpha-glucosidase inhibitor, and discuss its pharmacology, therapeutics, pharmacokinetics, dosing guidelines, adverse effects, drug interactions, and clinical efficacy.	miglitol	23-31	sucrase-isomaltase	Homo sapiens	44-61
11285328-0	2001	Fermented soybean-derived water-soluble Touchi extract inhibits alpha-glucosidase and is antiglycemic in rats and humans after single oral treatments.	Water	26-31	sucrase-isomaltase	Homo sapiens	64-81
11285328-0	2001	Fermented soybean-derived water-soluble Touchi extract inhibits alpha-glucosidase and is antiglycemic in rats and humans after single oral treatments.	touchi	40-46	sucrase-isomaltase	Homo sapiens	64-81
11285328-1	2001	A water-soluble extract of Touchi, a traditional Chinese food, was found to exert a strong inhibitory activity against rat intestinal alpha-glucosidase.	Water	2-7	sucrase-isomaltase	Homo sapiens	134-151
11171107-4	2001	We show that expression of the gene encoding sucrase-isomaltase is inhibited in the enterocytic Caco-2 clone TC7 by okadaic acid at a concentration that is known to inhibit protein phosphatases 1/2A and that does not affect cell viability.	Okadaic Acid	116-128	sucrase-isomaltase	Homo sapiens	45-63
11460577-10	2001	The category of agents that interfere with the absorption of glucose and lipids includes alpha-glucosidase inhibitors (acarbose and miglitol) and lipase inhibitors (or-listat).	Glucose	61-68	sucrase-isomaltase	Homo sapiens	89-106
16233012-3	2001	Alpha-glucosidase, whose spontaneous refolding yield from a urea-denatured state is up to 30% at a protein concentration of up to 10 microg/ml, could be refolded with a yield that was improved more than two-fold at a protein concentration more than five-fold higher when protein solution was circulated through an expanded bed under optimized conditions.	Urea	60-64	sucrase-isomaltase	Homo sapiens	0-17
11098345-5	2000	DATA SYNTHESIS: Miglitol is an alpha-glucosidase inhibitor that exerts its effect through the delayed absorption of complex carbohydrates in the small intestine, resulting in a decrease in postprandial glucose concentrations that are directly correlated with the dietary carbohydrate content.	Carbohydrates	124-137	sucrase-isomaltase	Homo sapiens	31-48
11098345-5	2000	DATA SYNTHESIS: Miglitol is an alpha-glucosidase inhibitor that exerts its effect through the delayed absorption of complex carbohydrates in the small intestine, resulting in a decrease in postprandial glucose concentrations that are directly correlated with the dietary carbohydrate content.	Glucose	202-209	sucrase-isomaltase	Homo sapiens	31-48
11098345-5	2000	DATA SYNTHESIS: Miglitol is an alpha-glucosidase inhibitor that exerts its effect through the delayed absorption of complex carbohydrates in the small intestine, resulting in a decrease in postprandial glucose concentrations that are directly correlated with the dietary carbohydrate content.	Carbohydrates	124-136	sucrase-isomaltase	Homo sapiens	31-48
11045457-5	2000	CP0P and 4,5,6,7-tetrachloro-N-(4-phenylbutyl)phthalimide (CP4P) proved to be more potent alpha-glucosidase inhibitors than the known inhibitor 1-deoxynojirimycin.	4,5,6,7-tetrachloro-n-(4-phenylbutyl)phthalimide	9-57	sucrase-isomaltase	Homo sapiens	90-107
11045457-0	2000	Alpha-glucosidase inhibitors with a phthalimide skeleton: structure-activity relationship study.	phthalimide	36-47	sucrase-isomaltase	Homo sapiens	0-17
11193416-0	2000	Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.	Flavonoids	59-68	sucrase-isomaltase	Homo sapiens	14-31
11193416-1	2000	Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1).	Flavonoids	31-41	sucrase-isomaltase	Homo sapiens	88-105
11045457-1	2000	Alpha-glucosidase inhibitors with a phthalimide skeleton were prepared.	phthalimide	36-47	sucrase-isomaltase	Homo sapiens	0-17
11045457-5	2000	CP0P and 4,5,6,7-tetrachloro-N-(4-phenylbutyl)phthalimide (CP4P) proved to be more potent alpha-glucosidase inhibitors than the known inhibitor 1-deoxynojirimycin.	CHEMBL275285	59-63	sucrase-isomaltase	Homo sapiens	90-107
11045457-5	2000	CP0P and 4,5,6,7-tetrachloro-N-(4-phenylbutyl)phthalimide (CP4P) proved to be more potent alpha-glucosidase inhibitors than the known inhibitor 1-deoxynojirimycin.	N-Phenyltetrachlorophthalimide	0-4	sucrase-isomaltase	Homo sapiens	90-107
10989161-1	2000	The aim of this study was to evaluate the efficacy of acarbose, an inhibitor of alpha-glucosidase, on glycemic control in elderly overweight type 2 diabetic patients poorly controlled by oral hypoglycemic agents (OHA) or insulin.	Acarbose	54-62	sucrase-isomaltase	Homo sapiens	80-97
10993209-1	2000	The inhibitory effects of natural and synthetic inhibitors on the intestinal membrane-bound hydrolase, alpha-glucosidase (AGH), were evaluated by using an immobilized cyanogen bromide-activated Sepharose 4B support.	Cyanogen Bromide	167-183	sucrase-isomaltase	Homo sapiens	103-120
10993209-1	2000	The inhibitory effects of natural and synthetic inhibitors on the intestinal membrane-bound hydrolase, alpha-glucosidase (AGH), were evaluated by using an immobilized cyanogen bromide-activated Sepharose 4B support.	Sepharose	194-203	sucrase-isomaltase	Homo sapiens	103-120
15700487-2	2000	The aim was to acquire data on the efficacy and tolerability of the alpha-glucosidase inhibitor, Miglitol, used in the doctor"s office setting.	miglitol	97-105	sucrase-isomaltase	Homo sapiens	68-85
11075724-7	2000	Since nutritional treatment did not successfully manage his reactive hypoglycemia, an alpha-glucosidase inhibitor, acarbose, was administered to treat his oxyhyperglycemia.	Acarbose	115-123	sucrase-isomaltase	Homo sapiens	86-103
10961161-2	2000	The alpha-glucosidase inhibitor acarbose increases the amount of starch entering the colon, and has been shown to increase faecal butyrate in humans.	Starch	65-71	sucrase-isomaltase	Homo sapiens	4-21
10961161-2	2000	The alpha-glucosidase inhibitor acarbose increases the amount of starch entering the colon, and has been shown to increase faecal butyrate in humans.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
10961161-2	2000	The alpha-glucosidase inhibitor acarbose increases the amount of starch entering the colon, and has been shown to increase faecal butyrate in humans.	Butyrates	130-138	sucrase-isomaltase	Homo sapiens	4-21
10975046-2	2000	Alpha-glucosidase inhibitors, led by acarbose, mainly address postprandial glucose control.	Acarbose	37-45	sucrase-isomaltase	Homo sapiens	0-17
10975046-2	2000	Alpha-glucosidase inhibitors, led by acarbose, mainly address postprandial glucose control.	Glucose	75-82	sucrase-isomaltase	Homo sapiens	0-17
10778865-2	2000	We assessed the effect of voglibose (alpha-glucosidase inhibitor) administration before the evening meal on nocturnal hypoglycemia in IDDM patients with intensive insulin therapy.	voglibose	26-35	sucrase-isomaltase	Homo sapiens	37-54
10872292-8	2000	The third group are the alpha-glucosidase inhibitors, e.g. acarbose.	Acarbose	59-67	sucrase-isomaltase	Homo sapiens	24-41
10788458-2	2000	In this study the proteolysis of intact viral capsid proteins, the alpha-glucosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-glucopyranoside and the lipoprotein lipase-catalyzed ester hydrolysis of resorufin were examined.	p-nitrophenyl-alpha-glucopyranoside	109-144	sucrase-isomaltase	Homo sapiens	67-84
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Glucose	141-148	sucrase-isomaltase	Homo sapiens	267-284
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Glucose	141-148	sucrase-isomaltase	Homo sapiens	294-311
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Arginine	65-75	sucrase-isomaltase	Homo sapiens	267-284
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Arginine	65-75	sucrase-isomaltase	Homo sapiens	294-311
10810293-9	2000	We propose that an important inhibitory effect of NO on the insulin secretory processes stimulated by glucose and l-arginine is exerted via inactivation of islet acid glucan-1,4-alpha-glucosidase, a putative key enzyme in nutrient-stimulated insulin release.	Glucose	102-109	sucrase-isomaltase	Homo sapiens	178-195
10810293-9	2000	We propose that an important inhibitory effect of NO on the insulin secretory processes stimulated by glucose and l-arginine is exerted via inactivation of islet acid glucan-1,4-alpha-glucosidase, a putative key enzyme in nutrient-stimulated insulin release.	Arginine	114-124	sucrase-isomaltase	Homo sapiens	178-195
10810293-4	2000	In isolated islets, NO derived from the intracellular NO donor hydroxylamine inhibited the activation of acid glucan-1, 4-alpha-glucosidase and its isoform acid alpha-glucosidase in parallel with inhibition of glucose-stimulated insulin release.	Hydroxylamine	63-76	sucrase-isomaltase	Homo sapiens	122-139
10810293-4	2000	In isolated islets, NO derived from the intracellular NO donor hydroxylamine inhibited the activation of acid glucan-1, 4-alpha-glucosidase and its isoform acid alpha-glucosidase in parallel with inhibition of glucose-stimulated insulin release.	Hydroxylamine	63-76	sucrase-isomaltase	Homo sapiens	161-178
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	NG-Nitroarginine Methyl Ester	54-88	sucrase-isomaltase	Homo sapiens	267-284
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	NG-Nitroarginine Methyl Ester	54-88	sucrase-isomaltase	Homo sapiens	294-311
11019430-1	2000	AIM: To investigate the effect of acarbose, intestinal alpha-glucosidase inhibitor, on lipid metabolism in patients with non-insulin-dependent diabetes mellitus (NIDDM).	Acarbose	34-42	sucrase-isomaltase	Homo sapiens	55-72
10803856-5	2000	The addition of alpha-glucosidase inhibitor, acarbose, improved glycaemic control irrespective of concomitant therapy for diabetes, although compliance with this agent was poor.	Acarbose	45-53	sucrase-isomaltase	Homo sapiens	16-33
11202216-2	2000	alpha-Glucosidase inhibitors slow carbohydrate absorption, resulting in reduced postprandial hyperglycemia; thiazolidinediones increase insulin sensitivity, especially in muscle and adipocytes; metformin decreases hepatic gluconeogenesis; sulfonylureas result in prolonged increases in insulin secretion; and meglitinide causes rapid, short-lived increases in insulin secretion.	Carbohydrates	34-46	sucrase-isomaltase	Homo sapiens	0-17
11202216-2	2000	alpha-Glucosidase inhibitors slow carbohydrate absorption, resulting in reduced postprandial hyperglycemia; thiazolidinediones increase insulin sensitivity, especially in muscle and adipocytes; metformin decreases hepatic gluconeogenesis; sulfonylureas result in prolonged increases in insulin secretion; and meglitinide causes rapid, short-lived increases in insulin secretion.	Metformin	194-203	sucrase-isomaltase	Homo sapiens	0-17
11202216-2	2000	alpha-Glucosidase inhibitors slow carbohydrate absorption, resulting in reduced postprandial hyperglycemia; thiazolidinediones increase insulin sensitivity, especially in muscle and adipocytes; metformin decreases hepatic gluconeogenesis; sulfonylureas result in prolonged increases in insulin secretion; and meglitinide causes rapid, short-lived increases in insulin secretion.	Sulfonylurea Compounds	239-252	sucrase-isomaltase	Homo sapiens	0-17
11202216-2	2000	alpha-Glucosidase inhibitors slow carbohydrate absorption, resulting in reduced postprandial hyperglycemia; thiazolidinediones increase insulin sensitivity, especially in muscle and adipocytes; metformin decreases hepatic gluconeogenesis; sulfonylureas result in prolonged increases in insulin secretion; and meglitinide causes rapid, short-lived increases in insulin secretion.	meglitinide	309-320	sucrase-isomaltase	Homo sapiens	0-17
10707569-2	2000	Many reports have demonstrated that the thiazolidinedione has the good hypoglycemic effect in monotherapy and in combination therapy with sulfonylureas, metformin, alpha-glucosidase inhibitors, or insulin.	2,4-thiazolidinedione	40-57	sucrase-isomaltase	Homo sapiens	164-181
10774102-3	2000	Six pregnant women who had moderate elevated level of blood glucose at fasting and postprandial were treated with acarbose, alpha-glucosidase inhibitor agent, given three times a day before meals.	Acarbose	114-122	sucrase-isomaltase	Homo sapiens	124-141
10357969-3	1999	In the present work, we studied the influence of different concentrations of testosterone, dihydrotestosterone and cyproterone acetate on the secretion of alpha-glucosidase, N-acetyl-glucosaminidase, beta-glucuronidase and alpha-mannosidase by isolated and cultured epithelial cells from human caput, corpus and cauda epididymides.	Testosterone	77-89	sucrase-isomaltase	Homo sapiens	155-172
11249557-2	1999	It is a derivative of 1-desoxynojirimycin, and binds reversibly to the brushborder alpha-glucosidase enzymes.	1-desoxynojirimycin	22-41	sucrase-isomaltase	Homo sapiens	83-100
10480189-3	1999	By inhibiting in a reversible way the hydrolysis of disaccharides and the ultimate steps of the digestion of dietary polysaccharides, alpha-glucosidase inhibitors reduce postprandial blood glucose raise in diabetics.	Disaccharides	52-65	sucrase-isomaltase	Homo sapiens	134-151
10480189-3	1999	By inhibiting in a reversible way the hydrolysis of disaccharides and the ultimate steps of the digestion of dietary polysaccharides, alpha-glucosidase inhibitors reduce postprandial blood glucose raise in diabetics.	Polysaccharides	117-132	sucrase-isomaltase	Homo sapiens	134-151
10643211-8	1999	The alpha-glucosidase inhibitors act nonsystemically by blocking the metabolism of digested polysaccharides and therefore lowering the amount of carbohydrate absorbed in a meal.	Polysaccharides	92-107	sucrase-isomaltase	Homo sapiens	4-21
10643211-8	1999	The alpha-glucosidase inhibitors act nonsystemically by blocking the metabolism of digested polysaccharides and therefore lowering the amount of carbohydrate absorbed in a meal.	Carbohydrates	145-157	sucrase-isomaltase	Homo sapiens	4-21
10364244-0	1999	Temporal association of the N- and O-linked glycosylation events and their implication in the polarized sorting of intestinal brush border sucrase-isomaltase, aminopeptidase N, and dipeptidyl peptidase IV.	Nitrogen	28-29	sucrase-isomaltase	Homo sapiens	139-157
10484389-8	1999	Addition of PD-98059 during differentiation interfered with sustained activation of p42 MAPK and sucrase-isomaltase expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	12-20	sucrase-isomaltase	Homo sapiens	97-115
10820647-5	1999	Recent years have witnessed the introduction of agents with novel modes of action, that is, the alpha-glucosidase inhibitors acarbose and miglitol (which reduce postprandial hyperglycaemia) and the first of the thiazolidinedione insulinsensitising drugs--troglitazone and rosiglitazone.	Acarbose	125-133	sucrase-isomaltase	Homo sapiens	96-113
10495478-0	1999	Effects of the alpha-glucosidase inhibitor acarbose on the development of long-term complications in diabetic animals: pathophysiological and therapeutic implications.	Acarbose	43-51	sucrase-isomaltase	Homo sapiens	15-32
10359703-0	1999	O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts.	o-linked glycans	0-16	sucrase-isomaltase	Homo sapiens	60-78
10359703-5	1999	Here, we have analysed the role of O-glycosylation in the apical sorting of sucrase-isomaltase (SI), a highly polarised N- and O-glycosylated intestinal enzyme, and the mechanisms underlying this process.	Nitrogen	120-121	sucrase-isomaltase	Homo sapiens	76-94
10359703-5	1999	Here, we have analysed the role of O-glycosylation in the apical sorting of sucrase-isomaltase (SI), a highly polarised N- and O-glycosylated intestinal enzyme, and the mechanisms underlying this process.	Nitrogen	120-121	sucrase-isomaltase	Homo sapiens	96-98
10359703-6	1999	Inhibition of O-glycosylation by benzyl-N-acetyl-alpha-D-galactosaminide (benzyl-GalNAc) was accompanied by a dramatic shift in the sorting of SI from the apical membrane to both membranes.	benzyl-alpha-N-acetylgalactosamine	33-72	sucrase-isomaltase	Homo sapiens	143-145
10359703-6	1999	Inhibition of O-glycosylation by benzyl-N-acetyl-alpha-D-galactosaminide (benzyl-GalNAc) was accompanied by a dramatic shift in the sorting of SI from the apical membrane to both membranes.	benzyl-galnac	74-87	sucrase-isomaltase	Homo sapiens	143-145
10359703-7	1999	The sorting mechanism of SI involves its association with sphingolipid- and cholesterol-rich membrane rafts because this association was eliminated when O-glycosylation was inhibited by benzyl-GaINAc.	Sphingolipids	58-70	sucrase-isomaltase	Homo sapiens	25-27
10359703-7	1999	The sorting mechanism of SI involves its association with sphingolipid- and cholesterol-rich membrane rafts because this association was eliminated when O-glycosylation was inhibited by benzyl-GaINAc.	Cholesterol	76-87	sucrase-isomaltase	Homo sapiens	25-27
10359703-7	1999	The sorting mechanism of SI involves its association with sphingolipid- and cholesterol-rich membrane rafts because this association was eliminated when O-glycosylation was inhibited by benzyl-GaINAc.	benzyl-gainac	186-199	sucrase-isomaltase	Homo sapiens	25-27
10357969-3	1999	In the present work, we studied the influence of different concentrations of testosterone, dihydrotestosterone and cyproterone acetate on the secretion of alpha-glucosidase, N-acetyl-glucosaminidase, beta-glucuronidase and alpha-mannosidase by isolated and cultured epithelial cells from human caput, corpus and cauda epididymides.	Dihydrotestosterone	91-110	sucrase-isomaltase	Homo sapiens	155-172
10357969-3	1999	In the present work, we studied the influence of different concentrations of testosterone, dihydrotestosterone and cyproterone acetate on the secretion of alpha-glucosidase, N-acetyl-glucosaminidase, beta-glucuronidase and alpha-mannosidase by isolated and cultured epithelial cells from human caput, corpus and cauda epididymides.	Cyproterone Acetate	115-134	sucrase-isomaltase	Homo sapiens	155-172
9918426-5	1998	Alpha-glucosidase inhibitor attenuates the postprandial increase of plasma glucose levels and is widely used for treatment of non-insulin-dependent diabetes mellitus (NIDDM).	Glucose	75-82	sucrase-isomaltase	Homo sapiens	0-17
10340610-1	1999	N-13C-methyl-deoxynojirimycin was synthesized and used in isotope-edited NMR studies to probe the binding site of an alpha-glucosidase.	n-13c-methyl-deoxynojirimycin	0-29	sucrase-isomaltase	Homo sapiens	117-134
10340610-2	1999	Results from this analysis led to the design and preparation of a novel alpha-glucosidase inhibitor, N-glycyl deoxynojirimycin.	n-glycyl deoxynojirimycin	101-126	sucrase-isomaltase	Homo sapiens	72-89
10220499-5	1999	Long-term pharmacological MAP kinase inhibition with the MEK inhibitor PD98059 induced expression of the terminal differentiation markers ITF, sucrase-isomaltase, and the mucin gene MUC2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	71-78	sucrase-isomaltase	Homo sapiens	143-161
10338221-7	1999	RESULTS: The methionine-sulfoximine-inhibited group was found to have lower sucrase-isomaltase activity, a lower density of microvilli, and lower electrical impedance values over time compared with the control group.	Methionine	13-23	sucrase-isomaltase	Homo sapiens	76-94
10338221-7	1999	RESULTS: The methionine-sulfoximine-inhibited group was found to have lower sucrase-isomaltase activity, a lower density of microvilli, and lower electrical impedance values over time compared with the control group.	sulfoximine	24-35	sucrase-isomaltase	Homo sapiens	76-94
10466209-1	1999	The hepatic lysosomal glycosidases alpha-glucosidase and beta-glucuronidase were inhibited in vitro and in vivo by mono- and diethanolamines.	mono- and diethanolamines	115-140	sucrase-isomaltase	Homo sapiens	35-52
10466209-3	1999	Phenyl 6-deoxy-6-(morpholin-4-yl)-beta-D-glucopyranoside inhibited alpha-glucosidase both in vitro and in vivo.	phenyl 6-deoxy-6-(morpholin-4-yl)-beta-d-glucopyranoside	0-56	sucrase-isomaltase	Homo sapiens	67-84
10466209-4	1999	The treatment of the enzymes in vitro by ethanolamine exhibited a reversible inhibition of the mixed and competitive types for alpha-glucosidase and beta-glucuronidase, respectively.	Ethanolamine	41-53	sucrase-isomaltase	Homo sapiens	127-144
10466209-6	1999	It is a potent inhibitor for beta-glucuronidase, in vitro, whose inhibition constant (Ki) is 5 x 10(-5) M. Phenyl 6-deoxy-6-(morpholin-4-yl)-beta-D-glucopyranoside is a potent inhibitor only for hepatic alpha-glucosidase with a Ki value of 1.6 x 10(-5) M. The pattern of the pH dependence of enzymic activity was not affected by ethanolamine inhibition.	phenyl 6-deoxy-6-(	107-125	sucrase-isomaltase	Homo sapiens	203-220
10466209-6	1999	It is a potent inhibitor for beta-glucuronidase, in vitro, whose inhibition constant (Ki) is 5 x 10(-5) M. Phenyl 6-deoxy-6-(morpholin-4-yl)-beta-D-glucopyranoside is a potent inhibitor only for hepatic alpha-glucosidase with a Ki value of 1.6 x 10(-5) M. The pattern of the pH dependence of enzymic activity was not affected by ethanolamine inhibition.	-4-yl)-beta-d-glucopyranoside	134-163	sucrase-isomaltase	Homo sapiens	203-220
10528419-0	1999	[Non-insulin-dependent diabetes mellitus associated with nonalcoholic liver cirrhosis: an evaluation of treatment with the intestinal alpha-glucosidase inhibitor acarbose].	Acarbose	162-170	sucrase-isomaltase	Homo sapiens	134-151
11220286-11	1999	Reducing the rate of glucose absorption with alpha-glucosidase inhibitors (e.g. acarbose) has been explored as an alternative approach to the management of postprandial hyperglycaemia, but these agents do not address the primary defect in type 2 diabetes.	Glucose	21-28	sucrase-isomaltase	Homo sapiens	45-62
11220286-11	1999	Reducing the rate of glucose absorption with alpha-glucosidase inhibitors (e.g. acarbose) has been explored as an alternative approach to the management of postprandial hyperglycaemia, but these agents do not address the primary defect in type 2 diabetes.	Acarbose	80-88	sucrase-isomaltase	Homo sapiens	45-62
10446691-0	1999	Troglitazone combination therapy in obese type 2 diabetic patients poorly controlled with alpha-glucosidase inhibitors.	Troglitazone	0-12	sucrase-isomaltase	Homo sapiens	90-107
10446691-1	1999	The efficacy and safety of treatment with troglitazone combined with an alpha-glucosidase inhibitor, in obese type 2 diabetic patients who were previously administered alpha-glucosidase inhibitors alone, in improving glycaemic control and reducing insulin resistance were studied.	Troglitazone	42-54	sucrase-isomaltase	Homo sapiens	168-185
9951949-12	1999	Alpha-Glucosidase inhibitors such as acarbose, miglitol and voglibose also reduce PPHG primarily by interfering with the carbohydrate-digesting enzymes and delaying glucose absorption.	Acarbose	37-45	sucrase-isomaltase	Homo sapiens	0-17
9951949-12	1999	Alpha-Glucosidase inhibitors such as acarbose, miglitol and voglibose also reduce PPHG primarily by interfering with the carbohydrate-digesting enzymes and delaying glucose absorption.	miglitol	47-55	sucrase-isomaltase	Homo sapiens	0-17
9951949-12	1999	Alpha-Glucosidase inhibitors such as acarbose, miglitol and voglibose also reduce PPHG primarily by interfering with the carbohydrate-digesting enzymes and delaying glucose absorption.	voglibose	60-69	sucrase-isomaltase	Homo sapiens	0-17
9951949-12	1999	Alpha-Glucosidase inhibitors such as acarbose, miglitol and voglibose also reduce PPHG primarily by interfering with the carbohydrate-digesting enzymes and delaying glucose absorption.	Carbohydrates	121-133	sucrase-isomaltase	Homo sapiens	0-17
9951949-12	1999	Alpha-Glucosidase inhibitors such as acarbose, miglitol and voglibose also reduce PPHG primarily by interfering with the carbohydrate-digesting enzymes and delaying glucose absorption.	Glucose	165-172	sucrase-isomaltase	Homo sapiens	0-17
9893692-7	1998	RECENT DRUGS: Acarbose, an alpha-glucosidase inhibitor, lowers post-prandial blood glucose level.	Acarbose	14-22	sucrase-isomaltase	Homo sapiens	27-44
9893692-7	1998	RECENT DRUGS: Acarbose, an alpha-glucosidase inhibitor, lowers post-prandial blood glucose level.	Glucose	83-90	sucrase-isomaltase	Homo sapiens	27-44
9893692-9	1998	Miglitol, another alpha-glucosidase inhibitor, would have the same therapeutic effect.	miglitol	0-8	sucrase-isomaltase	Homo sapiens	18-35
9918426-12	1998	These late dumping-related symptoms disappeared and a rapid change of plasma glucose and insulin levels were attenuated after the alpha-glucosidase inhibitor treatment.	Glucose	77-84	sucrase-isomaltase	Homo sapiens	130-147
9806892-0	1998	Two HNF-1 binding sites govern the glucose repression of the human sucrase-isomaltase promoter.	Glucose	35-42	sucrase-isomaltase	Homo sapiens	67-85
9806892-1	1998	We have previously shown, using the Caco-2 clone PF11, that glucose represses transcription of the human sucrase-isomaltase (SI) gene and that the -370/+30 fragment of the SI gene conferred glucose-regulated expression on a heterologous gene.	Glucose	60-67	sucrase-isomaltase	Homo sapiens	105-123
10051821-4	1998	Isradipine proved a good corrector of renal function after lithotripsy as it decreased enzymuria, promoted normalization of the activity of alkaline phosphatase, gamma-glutamyl transferase, alpha-glucosidase and lactate dehydrogenase to the end of the first postoperative month.	Isradipine	0-10	sucrase-isomaltase	Homo sapiens	190-207
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	Acarbose	34-42	sucrase-isomaltase	Homo sapiens	108-125
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	voglibose	44-53	sucrase-isomaltase	Homo sapiens	4-21
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	voglibose	44-53	sucrase-isomaltase	Homo sapiens	108-125
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	miglitol	58-66	sucrase-isomaltase	Homo sapiens	4-21
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	miglitol	58-66	sucrase-isomaltase	Homo sapiens	108-125
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	Carbohydrates	265-278	sucrase-isomaltase	Homo sapiens	4-21
9825953-14	1998	The alpha-glucosidase inhibitors, acarbose, voglibose and miglitol competitively and reversibly inhibit the alpha-glucosidase enzymes (glucoamylase, sucrase, maltase and isomaltase) in the brush border in the small intestine, which delays the hydrolysis of complex carbohydrates.	Carbohydrates	265-278	sucrase-isomaltase	Homo sapiens	108-125
9824974-5	1998	Alpha-glucosidase inhibitors such as acarbose and miglitol act locally in the GI tract to reduce postprandial excursion in glucose levels.	Acarbose	37-45	sucrase-isomaltase	Homo sapiens	0-17
9824974-5	1998	Alpha-glucosidase inhibitors such as acarbose and miglitol act locally in the GI tract to reduce postprandial excursion in glucose levels.	Glucose	123-130	sucrase-isomaltase	Homo sapiens	0-17
9804082-1	1998	We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.	voglibose	171-180	sucrase-isomaltase	Homo sapiens	142-159
9773737-2	1998	OBJECTIVE: To describe the rationale and design, and to discuss the preliminary screening data, of the Study to Prevent NIDDM (STOP-NIDDM Trial), an international study on the efficacy of the alpha-glucosidase inhibitor acarbose in preventing or delaying the development of type 2 diabetes in a population with impaired glucose tolerance (IGT).	Acarbose	220-228	sucrase-isomaltase	Homo sapiens	192-209
9924706-0	1998	Effect of an alpha-glucosidase inhibitor (voglibose), in combination with sulphonylureas, on glycaemic control in type 2 diabetes patients.	voglibose	42-51	sucrase-isomaltase	Homo sapiens	13-30
9924706-1	1998	A multicentre study was conducted to evaluate the effect of the alpha-glucosidase inhibitor, voglibose, on glycaemic control in 113 patients with type 2 diabetes whose blood glucose control was poor on treatment with a sulphonylurea drug.	voglibose	93-102	sucrase-isomaltase	Homo sapiens	64-81
9924706-6	1998	The results suggest that the combined use of this alpha-glucosidase inhibitor and sulphonylurea drugs may be effective in controlling plasma glucose in patients with type 2 diabetes and that this combination might delay the onset of vascular complications in these patients.	Glucose	141-148	sucrase-isomaltase	Homo sapiens	50-67
9739502-8	1998	Thus, the use of alpha-glucosidase inhibitors should be considered: (i) as a first-choice treatment in newly diagnosed patients; (ii) in individuals whose DM is not well controlled with any other type of treatment; (iii) as an alternative to sulphonylureas or biguanides in patients at risk from hypoglycaemia or lactic acidosis, respectively.	Biguanides	260-270	sucrase-isomaltase	Homo sapiens	17-34
9469188-0	1998	Acarbose, an alpha-glucosidase inhibitor for non-insulin-dependent diabetes.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
9703245-3	1998	This sustained collagen synthesis-promoting action is considered to be a major feature of the novel vitamin C derivative, AA-2G by conducting an experiment in which an alpha-glucosidase inhibitor was present, it was shown that AA-2G exerts its collagen synthesis-promoting action after being decomposed to AA by alpha-glucosidase.	Ascorbic Acid	100-109	sucrase-isomaltase	Homo sapiens	168-185
9703245-3	1998	This sustained collagen synthesis-promoting action is considered to be a major feature of the novel vitamin C derivative, AA-2G by conducting an experiment in which an alpha-glucosidase inhibitor was present, it was shown that AA-2G exerts its collagen synthesis-promoting action after being decomposed to AA by alpha-glucosidase.	Ascorbic Acid	100-109	sucrase-isomaltase	Homo sapiens	312-329
9740501-10	1998	These results provide a clear rationale for the therapeutic use of alpha-glucosidase inhibitors, such as acarbose, which attenuate postprandial hyperglycaemia-induced hyperinsulinaemia.	Acarbose	105-113	sucrase-isomaltase	Homo sapiens	67-84
9740503-9	1998	However, new agents that control postprandial hyperglycaemia have been developed, for example, the alpha-glucosidase inhibitor acarbose.	Acarbose	127-135	sucrase-isomaltase	Homo sapiens	99-116
9641747-2	1998	To determine whether an amylase (alpha-glucosidase) inhibitor, voglibose, can be useful in the control of hypoglycaemia, we tried it in a 14-y-old male with GSD Ib.	voglibose	63-72	sucrase-isomaltase	Homo sapiens	33-50
10178668-10	1998	The novel alpha-glucosidase inhibitor acarbose, in contrast, appears to be as effective as glibenclamide, but has the advantage of being bodyweight-neutral (reflecting group A).	Acarbose	38-46	sucrase-isomaltase	Homo sapiens	10-27
9530129-1	1998	An important signal involved in glucose-stimulated insulin secretion is transduced through the action of a lysosomal acid, glucan 1,4-alpha-glucosidase.	Glucose	32-39	sucrase-isomaltase	Homo sapiens	134-151
9530129-6	1998	This nifedipine-induced retention of Ca2+ was reflected in increased acid glucan 1,4-alpha-glucosidase activity.	Nifedipine	5-15	sucrase-isomaltase	Homo sapiens	85-102
9530129-9	1998	Hence, Ca(2+)-induced changes in acid glucan 1,4-alpha-glucosidase activity were intimately coupled to similar changes in Ca(2+)-glucose-induced insulin release.	Glucose	129-136	sucrase-isomaltase	Homo sapiens	49-66
9572418-6	1998	The activity of alpha-GLUC was inversely correlated with ROS generation after 12-myristate, 13-acetate phorbol ester stimulation (r=-0.27, n=104), and both alpha-GLUC activity and total output were inversely correlated with the concentration of peroxidase-positive white blood cells among samples with &gt; or =1x10(6)/ml of these cells (r=-0.30 and -0.19, n=165).	ros	57-60	sucrase-isomaltase	Homo sapiens	16-26
9572418-6	1998	The activity of alpha-GLUC was inversely correlated with ROS generation after 12-myristate, 13-acetate phorbol ester stimulation (r=-0.27, n=104), and both alpha-GLUC activity and total output were inversely correlated with the concentration of peroxidase-positive white blood cells among samples with &gt; or =1x10(6)/ml of these cells (r=-0.30 and -0.19, n=165).	13-acetate phorbol ester	92-116	sucrase-isomaltase	Homo sapiens	16-26
9789590-3	1998	Alpha glucosidase inhibitors, available in France since 1993, constitute another therapeutic approach, reducing postprandial hyperglycemia by delaying the digestion of complex carbohydrates.	Carbohydrates	176-189	sucrase-isomaltase	Homo sapiens	0-17
9647342-1	1998	Acarbose is the first of a new class of antidiabetic agents, the alpha-glucosidase inhibitors.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	65-82
9663365-1	1998	Acarbose is an alpha-glucosidase inhibitor approved for the treatment of type 2 diabetes mellitus.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	15-32
9540025-12	1998	alpha-Glucosidase treatment may be an important therapeutic option in these patients in view of their greater risk for microvascular complications and the accumulating body of evidence that better glucose control reduces the risk of these complications.	Glucose	197-204	sucrase-isomaltase	Homo sapiens	0-17
11234255-1	1998	UNLABELLED: Acarbose is an alpha-glucosidase inhibitor which reversibly inhibits oligosaccharidase and disaccharidase at the brush border of the small intestine.	Acarbose	12-20	sucrase-isomaltase	Homo sapiens	27-44
9371013-4	1997	Acarbose is an alpha-glucosidase inhibitor that improves glycemic control by decreasing the intestinal absorption of glucose, thereby decreasing postprandial glucose elevations.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	15-32
9750481-1	1998	In the treatment of type 2 diabetes (NIDDM) we possess three groups of oral hypoglycaemic drugs: sulfonyl urea derivatives, biguanides (metformin) and alpha-glucosidase (acarbose) inhibitors.	Acarbose	170-178	sucrase-isomaltase	Homo sapiens	151-168
9371013-4	1997	Acarbose is an alpha-glucosidase inhibitor that improves glycemic control by decreasing the intestinal absorption of glucose, thereby decreasing postprandial glucose elevations.	Glucose	117-124	sucrase-isomaltase	Homo sapiens	15-32
9371013-4	1997	Acarbose is an alpha-glucosidase inhibitor that improves glycemic control by decreasing the intestinal absorption of glucose, thereby decreasing postprandial glucose elevations.	Glucose	158-165	sucrase-isomaltase	Homo sapiens	15-32
9376887-1	1997	OBJECTIVES: To see if the long-term treatment of non-insulin dependent diabetes (NIDDM) with the alpha-glucosidase inhibitor acarbose affects food intake and body weight.	Acarbose	125-133	sucrase-isomaltase	Homo sapiens	97-114
9600167-2	1997	As to seminal plasma, the authors consider it useful and relevant to assess citric acid levels, total acid phosphatases and in particular fructose with alpha-glucosidase.	Fructose	138-146	sucrase-isomaltase	Homo sapiens	152-169
9314014-1	1997	Alpha-glucosidase inhibitors are antihyperglycemic agents that lower blood glucose by delaying the digestion and absorption of complex carbohydrates.	Glucose	75-82	sucrase-isomaltase	Homo sapiens	0-17
9314014-1	1997	Alpha-glucosidase inhibitors are antihyperglycemic agents that lower blood glucose by delaying the digestion and absorption of complex carbohydrates.	Carbohydrates	135-148	sucrase-isomaltase	Homo sapiens	0-17
9589946-0	1997	[The use of the alpha-glucosidase inhibitor acarbose for the treatment of type-2 diabetes mellitus in secondary sulfanilamide resistance].	Acarbose	44-52	sucrase-isomaltase	Homo sapiens	16-33
9589946-0	1997	[The use of the alpha-glucosidase inhibitor acarbose for the treatment of type-2 diabetes mellitus in secondary sulfanilamide resistance].	Sulfanilamide	112-125	sucrase-isomaltase	Homo sapiens	16-33
9301101-2	1997	alpha-Glucosidase and glucoamylase are essentially distinguished by releasing alpha-glucose and beta-glucose, respectively, from the common substrates having alpha-glucosidic linkage.	alpha-D-glucose	78-91	sucrase-isomaltase	Homo sapiens	0-17
9351216-0	1997	Utilization of starch and synthesis of a combined amylase/alpha-glucosidase by the human colonic anaerobe Bacteroides ovatus.	Starch	15-21	sucrase-isomaltase	Homo sapiens	58-75
9301101-2	1997	alpha-Glucosidase and glucoamylase are essentially distinguished by releasing alpha-glucose and beta-glucose, respectively, from the common substrates having alpha-glucosidic linkage.	Zymosan	96-108	sucrase-isomaltase	Homo sapiens	0-17
9164838-12	1997	The lysosomal enzymes in urine containing the highest proportion of mannose-6-phosphorylated form were beta-mannosidase (82%), hexosaminidase (27%) and alpha-glucosidase (24%).	mannose-6	68-77	sucrase-isomaltase	Homo sapiens	152-169
9580485-0	1997	[Clinical experience with an alpha glucosidase inhibitor (acarbose) in the treatment of non-insulin-dependent diabetes.	Acarbose	58-66	sucrase-isomaltase	Homo sapiens	29-46
9580485-2	1997	BACKGROUND: Acarbose, an alpha glucosidase inhibitor is a drug used in the treatment of non insulin dependent diabetes mellitus, that interferes with the intestinal absorption of monosaccharides.	Acarbose	12-20	sucrase-isomaltase	Homo sapiens	25-42
9580485-2	1997	BACKGROUND: Acarbose, an alpha glucosidase inhibitor is a drug used in the treatment of non insulin dependent diabetes mellitus, that interferes with the intestinal absorption of monosaccharides.	Monosaccharides	179-194	sucrase-isomaltase	Homo sapiens	25-42
9145529-1	1997	Glycosyl-trehaloses with an isomaltosyl residue were synthesized by alpha-glucosidase from Aspergillus niger by using maltotetraose as a glucosyl donor and trehalose as the acceptor.	glycosyl-trehaloses	0-19	sucrase-isomaltase	Homo sapiens	68-85
9145529-1	1997	Glycosyl-trehaloses with an isomaltosyl residue were synthesized by alpha-glucosidase from Aspergillus niger by using maltotetraose as a glucosyl donor and trehalose as the acceptor.	maltotetraose	118-131	sucrase-isomaltase	Homo sapiens	68-85
9145529-1	1997	Glycosyl-trehaloses with an isomaltosyl residue were synthesized by alpha-glucosidase from Aspergillus niger by using maltotetraose as a glucosyl donor and trehalose as the acceptor.	Trehalose	9-18	sucrase-isomaltase	Homo sapiens	68-85
8893066-0	1996	Acarbose: an alpha-glucosidase inhibitor.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
9050863-4	1997	In the presence of N-butyl-deoxnojirimycin (an inhibitor of alpha-glucosidase) virions and the M protein are surprisingly retained.	n-butyl-deoxnojirimycin	19-42	sucrase-isomaltase	Homo sapiens	60-77
9209707-0	1997	Glucose-dependent transcriptional regulation of the human sucrase-isomaltase (SI) gene.	Glucose	0-7	sucrase-isomaltase	Homo sapiens	58-76
9209707-0	1997	Glucose-dependent transcriptional regulation of the human sucrase-isomaltase (SI) gene.	Glucose	0-7	sucrase-isomaltase	Homo sapiens	78-80
9209707-1	1997	We have previously shown that the transcription of the human sucrase-isomaltase (SI) gene was negatively regulated by glucose.	Glucose	118-125	sucrase-isomaltase	Homo sapiens	61-79
9209707-1	1997	We have previously shown that the transcription of the human sucrase-isomaltase (SI) gene was negatively regulated by glucose.	Glucose	118-125	sucrase-isomaltase	Homo sapiens	81-83
9051408-0	1997	Rapid improvement of serum 1,5-anhydroglucitol concentrations after administration of alpha-glucosidase inhibitor.	1,5-anhydroglucitol	27-46	sucrase-isomaltase	Homo sapiens	86-103
9092938-3	1997	Expression of this mutant sucrase-isomaltase cDNA in COS-1 cells results in an accumulation of sucrase-isomaltase in the ER, intermediate compartment and the cis-Golgi cisternae similar to the accumulation in phenotype II intestinal cells.	carbonyl sulfide	53-56	sucrase-isomaltase	Homo sapiens	26-44
9092938-3	1997	Expression of this mutant sucrase-isomaltase cDNA in COS-1 cells results in an accumulation of sucrase-isomaltase in the ER, intermediate compartment and the cis-Golgi cisternae similar to the accumulation in phenotype II intestinal cells.	carbonyl sulfide	53-56	sucrase-isomaltase	Homo sapiens	95-113
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Glutamine	19-28	sucrase-isomaltase	Homo sapiens	81-98
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Glutamine	19-28	sucrase-isomaltase	Homo sapiens	319-337
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Proline	102-109	sucrase-isomaltase	Homo sapiens	81-98
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Proline	102-109	sucrase-isomaltase	Homo sapiens	319-337
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Mannose	276-283	sucrase-isomaltase	Homo sapiens	81-98
9083705-3	1997	Acarbose, the first alpha-glucosidase inhibitor available in the United States, exerts its activity in the gastrointestinal tract.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	20-37
9403288-0	1997	Concomitant administration of the alpha-glucosidase inhibitor voglibose (AO-128) does not alter the pharmacokinetics of glibenclamide.	voglibose	62-71	sucrase-isomaltase	Homo sapiens	34-51
9403288-0	1997	Concomitant administration of the alpha-glucosidase inhibitor voglibose (AO-128) does not alter the pharmacokinetics of glibenclamide.	AO 128	73-79	sucrase-isomaltase	Homo sapiens	34-51
8944206-7	1996	Alpha-glucosidase inhibitors reversibly inhibit alpha-glucosidase enzymes in the small intestine, which delays cleavage of oligo- and disaccharides to monosaccharides.	oligo- and disaccharides	123-147	sucrase-isomaltase	Homo sapiens	0-17
8944206-7	1996	Alpha-glucosidase inhibitors reversibly inhibit alpha-glucosidase enzymes in the small intestine, which delays cleavage of oligo- and disaccharides to monosaccharides.	oligo- and disaccharides	123-147	sucrase-isomaltase	Homo sapiens	48-65
8944206-7	1996	Alpha-glucosidase inhibitors reversibly inhibit alpha-glucosidase enzymes in the small intestine, which delays cleavage of oligo- and disaccharides to monosaccharides.	Monosaccharides	151-166	sucrase-isomaltase	Homo sapiens	0-17
8944206-7	1996	Alpha-glucosidase inhibitors reversibly inhibit alpha-glucosidase enzymes in the small intestine, which delays cleavage of oligo- and disaccharides to monosaccharides.	Monosaccharides	151-166	sucrase-isomaltase	Homo sapiens	48-65
8856576-6	1996	The inhibition of sucrase isomaltase by acarbose impedes the absorption of sucrose but not of the fructose-glucose mixture.	Sucrose	75-82	sucrase-isomaltase	Homo sapiens	18-36
8879556-8	1996	However, the phosphonamidate gave moderate competitive inhibition of the two inverting glycosidases and the retaining alpha-glucosidase but no inhibition of beta-glucosidase.	phosphonamidate	13-28	sucrase-isomaltase	Homo sapiens	118-135
9123978-2	1996	Inhibition of glucoamylase, alpha-amylase and alpha-glucosidase by heat treated alpha-glucans and melanoidins].	alpha-glucans	80-93	sucrase-isomaltase	Homo sapiens	46-63
9123978-2	1996	Inhibition of glucoamylase, alpha-amylase and alpha-glucosidase by heat treated alpha-glucans and melanoidins].	melanoidin polymers	98-109	sucrase-isomaltase	Homo sapiens	46-63
9123978-6	1996	Glucoamylase and alpha-amylase are not inhibited by non-dialysed melanoidines from the reaction of D-glucose and glycine, but there is a strong inhibition of alpha-glucosidase by these melanoidines (up to 45%).	melanoidines	185-197	sucrase-isomaltase	Homo sapiens	158-175
9254525-0	1996	[Synthesis of beta-maltosides, derivatives of p-nitrophenol, 2-chloro-4-nitrophenol, and 4-methylumbelliferone, and their use as substrates for determining alpha-glucosidase activity].	beta-maltosides	14-29	sucrase-isomaltase	Homo sapiens	156-173
9254525-0	1996	[Synthesis of beta-maltosides, derivatives of p-nitrophenol, 2-chloro-4-nitrophenol, and 4-methylumbelliferone, and their use as substrates for determining alpha-glucosidase activity].	Hymecromone	89-110	sucrase-isomaltase	Homo sapiens	156-173
9254525-3	1996	The method of assay of neutral alpha-glucosidase from human kidney and urine using synthesized beta-maltosides (p-nitrophenyl-beta-D-maltoside, 2-chloro-4-nitrophenyl-beta-D-maltoside and 4-methylumbelliferyl-beta-D-maltoside) as substrates and beta-glucosidase as an auxiliary enzyme is proposed.	beta-maltosides	95-110	sucrase-isomaltase	Homo sapiens	31-48
9254525-4	1996	The method is simple, convenient and 10-fold more sensitive than the commonly used alpha-glucosidase assay procedure with the corresponding synthetic alpha-glucosides, p-nitrophenyl-alpha-D-glucoside and 4-methylumbelliferyl-alpha-D-glucoside.	alpha-glucosides	150-166	sucrase-isomaltase	Homo sapiens	83-100
9254525-4	1996	The method is simple, convenient and 10-fold more sensitive than the commonly used alpha-glucosidase assay procedure with the corresponding synthetic alpha-glucosides, p-nitrophenyl-alpha-D-glucoside and 4-methylumbelliferyl-alpha-D-glucoside.	4-nitrophenyl alpha-glucoside	168-199	sucrase-isomaltase	Homo sapiens	83-100
9254525-4	1996	The method is simple, convenient and 10-fold more sensitive than the commonly used alpha-glucosidase assay procedure with the corresponding synthetic alpha-glucosides, p-nitrophenyl-alpha-D-glucoside and 4-methylumbelliferyl-alpha-D-glucoside.	4-methylumbelliferyl-alpha-d-glucoside	204-242	sucrase-isomaltase	Homo sapiens	83-100
9254525-5	1996	A modification of the method, with p-nitrophenyl-beta-D-maltoside as substrate, was applied to the semi-automatic assay of urinary alpha-glucosidase in 96-well microtitre plates.	p-nitrophenyl-beta-d-maltoside	35-65	sucrase-isomaltase	Homo sapiens	131-148
8949640-3	1996	RESULTS: Oral administration of the alpha-glucosidase inhibitor "Acarbose" (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold.	Acarbose	65-73	sucrase-isomaltase	Homo sapiens	36-53
8949640-3	1996	RESULTS: Oral administration of the alpha-glucosidase inhibitor "Acarbose" (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold.	Acarbose	76-86	sucrase-isomaltase	Homo sapiens	36-53
8949640-3	1996	RESULTS: Oral administration of the alpha-glucosidase inhibitor "Acarbose" (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold.	Sucrose	110-117	sucrase-isomaltase	Homo sapiens	36-53
8949640-3	1996	RESULTS: Oral administration of the alpha-glucosidase inhibitor "Acarbose" (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold.	Lactulose	122-131	sucrase-isomaltase	Homo sapiens	36-53
8949640-3	1996	RESULTS: Oral administration of the alpha-glucosidase inhibitor "Acarbose" (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold.	Sucrose	154-161	sucrase-isomaltase	Homo sapiens	36-53
8949640-3	1996	RESULTS: Oral administration of the alpha-glucosidase inhibitor "Acarbose" (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold.	Lactulose	162-171	sucrase-isomaltase	Homo sapiens	36-53
8895047-5	1996	These preliminary results indicate that the addition of a very low dose of tolbutamide to a recommended diet and treatment with an alpha-glucosidase inhibitor, may improve glucose metabolism without raising insulin secretion or influencing lipid metabolism.	Tolbutamide	75-86	sucrase-isomaltase	Homo sapiens	131-148
8895047-5	1996	These preliminary results indicate that the addition of a very low dose of tolbutamide to a recommended diet and treatment with an alpha-glucosidase inhibitor, may improve glucose metabolism without raising insulin secretion or influencing lipid metabolism.	Glucose	172-179	sucrase-isomaltase	Homo sapiens	131-148
8923673-0	1996	Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats.	-n-butyl-1-deoxynojiromycin	25-52	sucrase-isomaltase	Homo sapiens	57-74
8923673-1	1996	Perbutylated-N-butyl-1-deoxynojiromycin (p-N-butyl-DNJ, SC-49483), an alpha-glucosidase-1 inhibitor, is a candidate anti-HIV agent targeted against viral glycoprotein processing in host cell endoplasmic reticulum.	-n-butyl-1-deoxynojiromycin	12-39	sucrase-isomaltase	Homo sapiens	70-87
8923673-1	1996	Perbutylated-N-butyl-1-deoxynojiromycin (p-N-butyl-DNJ, SC-49483), an alpha-glucosidase-1 inhibitor, is a candidate anti-HIV agent targeted against viral glycoprotein processing in host cell endoplasmic reticulum.	glycovir	41-54	sucrase-isomaltase	Homo sapiens	70-87
8923673-1	1996	Perbutylated-N-butyl-1-deoxynojiromycin (p-N-butyl-DNJ, SC-49483), an alpha-glucosidase-1 inhibitor, is a candidate anti-HIV agent targeted against viral glycoprotein processing in host cell endoplasmic reticulum.	glycovir	56-64	sucrase-isomaltase	Homo sapiens	70-87
8923673-10	1996	We believe that morphologic changes in thyroid follicular cells, salivary gland acinar cells, pancreatic acinar cells, and gastric chief cells were the result of nonspecific inhibition of host alpha-glucosidase(s) by p-N-butyl-DNJ, causing clinically silent perturbation in host cell glycoprotein processing and/or glycoprotein transport.	glycovir	217-230	sucrase-isomaltase	Homo sapiens	193-210
9237214-2	1996	One of the hexapeptide lactam libraries (cyclo[xXxXxN]) was found to have significant alpha-glucosidase inhibitory activity.	Lactams	23-29	sucrase-isomaltase	Homo sapiens	86-103
8863857-10	1996	SI was found in 70% adenocarcinomas, 50% villous, 25% tubulovillous and 19% tubular adenomas when the method with sucrose, glucose oxidase-peroxidase and 3,3"-diaminobenzidine was used.	Sucrose	114-121	sucrase-isomaltase	Homo sapiens	0-2
8921700-1	1996	Alpha-glucosidase inhibitor can suppress postprandial hyperglycemia by delaying the absorption of carbohydrates in the intestine, and may be useful in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) and preserved insulin secretion.	Carbohydrates	98-111	sucrase-isomaltase	Homo sapiens	0-17
8863857-10	1996	SI was found in 70% adenocarcinomas, 50% villous, 25% tubulovillous and 19% tubular adenomas when the method with sucrose, glucose oxidase-peroxidase and 3,3"-diaminobenzidine was used.	3,3'-Diaminobenzidine	154-175	sucrase-isomaltase	Homo sapiens	0-2
8637448-0	1996	Improvement of insulin sensitivity and dyslipidemia with a new alpha-glucosidase inhibitor, voglibose, in nondiabetic hyperinsulinemic subjects.	voglibose	92-101	sucrase-isomaltase	Homo sapiens	63-80
8725865-0	1996	An importance of carbohydrate ingestion for the expression of the effect of alpha-glucosidase inhibitor in NIDDM.	Carbohydrates	17-29	sucrase-isomaltase	Homo sapiens	76-93
8725865-7	1996	RESULTS: Treatment with alpha-glucosidase inhibitors during the hospital stay markedly improved circadian variation in blood glucose levels and HbA1c and decreased urine C-peptide in both groups.	Glucose	125-132	sucrase-isomaltase	Homo sapiens	24-41
8764205-6	1996	These results suggest that activation of CYP1A1, whether spontaneous or drug induced, is involved in the variations of glucose utilization and in the associated modifications of expression of sucrase-isomaltase and hexose transporters.	Glucose	119-126	sucrase-isomaltase	Homo sapiens	192-210
8637448-1	1996	This study was undertaken to investigate the effect of voglibose, a new alpha-glucosidase inhibitor, on glucose and lipid metabolism in nondiabetic hyperinsulinemic subjects.	voglibose	55-64	sucrase-isomaltase	Homo sapiens	72-89
8704327-0	1996	Digalactosyldiacylglycerol suppression of inhibition by sulfoquinovosyldiacylglycerol of alpha-glucosidase.	digalactosyldiacylglycerol	0-26	sucrase-isomaltase	Homo sapiens	89-106
8660508-2	1996	The procedure involves in situ disruption of cells, followed by hydrolysis of glycogen into glucosyl units by fungal glucoamylase (exo-1.4-alpha-glucosidase, EC 3.2.1.3), and glucose determination with the glucose oxidase colorimetric method.	Glycogen	78-86	sucrase-isomaltase	Homo sapiens	139-156
8704327-0	1996	Digalactosyldiacylglycerol suppression of inhibition by sulfoquinovosyldiacylglycerol of alpha-glucosidase.	sulfoquinovosyldiacylglycerol	56-85	sucrase-isomaltase	Homo sapiens	89-106
8704327-1	1996	Digalactosyldiacylglycerol (DGDG) suppressed the inhibition by sulfoquinovosyldiacylglycerol (SQDG) of an alpha-glucosidase reaction.	digalactosyldiacylglycerol	0-26	sucrase-isomaltase	Homo sapiens	106-123
8704327-1	1996	Digalactosyldiacylglycerol (DGDG) suppressed the inhibition by sulfoquinovosyldiacylglycerol (SQDG) of an alpha-glucosidase reaction.	digalactosyldiacylglycerol	28-32	sucrase-isomaltase	Homo sapiens	106-123
8704327-1	1996	Digalactosyldiacylglycerol (DGDG) suppressed the inhibition by sulfoquinovosyldiacylglycerol (SQDG) of an alpha-glucosidase reaction.	sulfoquinovosyldiacylglycerol	63-92	sucrase-isomaltase	Homo sapiens	106-123
8704327-1	1996	Digalactosyldiacylglycerol (DGDG) suppressed the inhibition by sulfoquinovosyldiacylglycerol (SQDG) of an alpha-glucosidase reaction.	sulfoquinovosyl diglyceride	94-98	sucrase-isomaltase	Homo sapiens	106-123
8670122-1	1996	We have previously shown that glucose can exert a repressive effect on the transcription of the sucrase-isomaltase (SI) gene in the differentiated enterocyte-like human colon carcinoma cell lines HT-29 and Caco-2.	Glucose	30-37	sucrase-isomaltase	Homo sapiens	96-114
8670122-1	1996	We have previously shown that glucose can exert a repressive effect on the transcription of the sucrase-isomaltase (SI) gene in the differentiated enterocyte-like human colon carcinoma cell lines HT-29 and Caco-2.	Glucose	30-37	sucrase-isomaltase	Homo sapiens	116-118
8670122-4	1996	By using the stably transformed PF11 cells grown either in standard high glucose (25 mM) or in low glucose (1 mM) it was possible to show that the smallest fragment of the SI promoter, extending from bases -370 to +30, contains all the information required for the glucose repression of the reporter gene luciferase.	Glucose	73-80	sucrase-isomaltase	Homo sapiens	172-174
8670122-4	1996	By using the stably transformed PF11 cells grown either in standard high glucose (25 mM) or in low glucose (1 mM) it was possible to show that the smallest fragment of the SI promoter, extending from bases -370 to +30, contains all the information required for the glucose repression of the reporter gene luciferase.	Glucose	99-106	sucrase-isomaltase	Homo sapiens	172-174
8670122-4	1996	By using the stably transformed PF11 cells grown either in standard high glucose (25 mM) or in low glucose (1 mM) it was possible to show that the smallest fragment of the SI promoter, extending from bases -370 to +30, contains all the information required for the glucose repression of the reporter gene luciferase.	Glucose	99-106	sucrase-isomaltase	Homo sapiens	172-174
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Arginine	192-195	sucrase-isomaltase	Homo sapiens	79-97
8721135-5	1996	Acarbose, alpha-glucosidase inhibitor, suppresses the breakdown of carbohydrates in the small intestine and consequently reduced osmolarity.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	10-27
8721135-5	1996	Acarbose, alpha-glucosidase inhibitor, suppresses the breakdown of carbohydrates in the small intestine and consequently reduced osmolarity.	Carbohydrates	67-80	sucrase-isomaltase	Homo sapiens	10-27
8660303-7	1996	Furthermore, treatment in Caco-2 cells with brefeldin A led to changes in alpha-glucosidase maturation similar to those observed in untreated M6 cells.	Brefeldin A	44-55	sucrase-isomaltase	Homo sapiens	74-91
8598220-0	1996	Triiodothyronine stimulates the expression of sucrase-isomaltase in Caco-2 cells cultured in serum-free medium.	Triiodothyronine	0-16	sucrase-isomaltase	Homo sapiens	46-64
8714432-0	1996	Use of beta-maltosides (p-nitrophenyl-beta-D-maltoside, 2-chloro-4- nitrophenyl-beta-D-maltoside and 4-methylumbelliferyl-beta-D-maltoside) as substrates for the assay of neutral alpha-glucosidase from human kidney and urine.	p-nitrophenyl-beta-d-maltoside	24-54	sucrase-isomaltase	Homo sapiens	179-196
8714432-2	1996	All three beta-maltosides are suitable substrates for the determination of neutral alpha-glucosidase activity but MU-beta-D-maltoside is the most sensitive due to its methylumbelliferyl moiety.	beta-maltosides	10-25	sucrase-isomaltase	Homo sapiens	83-100
8714432-2	1996	All three beta-maltosides are suitable substrates for the determination of neutral alpha-glucosidase activity but MU-beta-D-maltoside is the most sensitive due to its methylumbelliferyl moiety.	mu-beta-d-maltoside	114-133	sucrase-isomaltase	Homo sapiens	83-100
8714432-3	1996	The method is simple, convenient and 10-fold more sensitive than the commonly used alpha-glucosidase assay procedure with the corresponding synthetic alpha-glucosides, p-nitrophenyl- alpha-D-glucoside (NP-alpha-D-glucoside) and 4-methylumbelliferyl-alpha-D-glucoside (MU-alpha-D-glucoside).	alpha-glucosides	150-166	sucrase-isomaltase	Homo sapiens	83-100
8714432-4	1996	A modification of the method, with p-nitrophenyl-beta-D-maltoside as substrate, was applied to the semiautomatic assay of urinary alpha-glucosidase in 96-well microtitre plates.	p-nitrophenyl-beta-d-maltoside	35-65	sucrase-isomaltase	Homo sapiens	130-147
8609217-1	1996	Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment.	Glutamine	20-29	sucrase-isomaltase	Homo sapiens	89-107
8609217-1	1996	Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment.	Proline	33-40	sucrase-isomaltase	Homo sapiens	89-107
8609217-3	1996	Here, we analyze at the molecular level a phenotype of congenital sucrase-isomaltase deficiency in which sucrase-isomaltase (SI) is not transported to the brush border membrane but accumulates as a mannose-rich precursor in the endoplasmic reticulum (ER), ER-Golgi intermediate compartment, and the cis-Golgi, where it is finally degraded.	Mannose	198-205	sucrase-isomaltase	Homo sapiens	66-84
8726284-2	1996	The digestion of disaccharides and some oligosaccharides is undertaken by a number of small intestinal brush border enzymes: sucrase-isomaltase, lactase phlorizinhydrolase, maltase-glycoamylase and trehalase.	Disaccharides	17-30	sucrase-isomaltase	Homo sapiens	125-143
8726284-2	1996	The digestion of disaccharides and some oligosaccharides is undertaken by a number of small intestinal brush border enzymes: sucrase-isomaltase, lactase phlorizinhydrolase, maltase-glycoamylase and trehalase.	Oligosaccharides	40-56	sucrase-isomaltase	Homo sapiens	125-143
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Arginine	192-195	sucrase-isomaltase	Homo sapiens	239-257
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	196-199	sucrase-isomaltase	Homo sapiens	79-97
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	196-199	sucrase-isomaltase	Homo sapiens	239-257
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	200-203	sucrase-isomaltase	Homo sapiens	79-97
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	200-203	sucrase-isomaltase	Homo sapiens	239-257
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Phenylalanine	204-207	sucrase-isomaltase	Homo sapiens	79-97
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Phenylalanine	204-207	sucrase-isomaltase	Homo sapiens	239-257
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Serine	169-172	sucrase-isomaltase	Homo sapiens	79-97
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Serine	169-172	sucrase-isomaltase	Homo sapiens	239-257
8576667-0	1995	Effects of alpha-glucosidase inhibitor (acarbose) combined with sulfonylurea or sulfonylurea and metformin in treatment of non-insulin-dependent diabetes mellitus.	Acarbose	40-48	sucrase-isomaltase	Homo sapiens	11-28
8567098-5	1995	In addition, the total amounts of testosterone and DHT were correlated with total activity of alpha-glucosidase (r = 0.49, p &lt; 0.001; r = 0.58, p &lt; 0.01), and gamma-glutamyltransferase (r = 0.49, p &lt; 0.001; r = 0.48, p &lt; 0.001) in seminal plasma.	Testosterone	34-46	sucrase-isomaltase	Homo sapiens	94-111
8746620-0	1995	Can alpha-glucosidase inhibitors reduce the dosage of sulphonylurea compounds needed by patients with non-insulin-dependent diabetes mellitus?	Sulfonylurea Compounds	54-67	sucrase-isomaltase	Homo sapiens	4-21
8562269-6	1995	This strategy involves the use of inhibitors of alpha-glucosidase, an intestinal enzyme that participates in the breakdown of polysaccharides into disaccharides and monosaccharides.	Polysaccharides	126-141	sucrase-isomaltase	Homo sapiens	48-65
8562269-6	1995	This strategy involves the use of inhibitors of alpha-glucosidase, an intestinal enzyme that participates in the breakdown of polysaccharides into disaccharides and monosaccharides.	Disaccharides	147-160	sucrase-isomaltase	Homo sapiens	48-65
8562269-6	1995	This strategy involves the use of inhibitors of alpha-glucosidase, an intestinal enzyme that participates in the breakdown of polysaccharides into disaccharides and monosaccharides.	Monosaccharides	165-180	sucrase-isomaltase	Homo sapiens	48-65
8562269-7	1995	The inhibition of alpha-glucosidase by these agents is competitive and reversible and results in delayed and reduced uptake of carbohydrates across the intestine.	Carbohydrates	127-140	sucrase-isomaltase	Homo sapiens	18-35
8562269-9	1995	The compound acarbose is a member of first generation alpha-glucosidase inhibitors.	Acarbose	13-21	sucrase-isomaltase	Homo sapiens	54-71
8567098-5	1995	In addition, the total amounts of testosterone and DHT were correlated with total activity of alpha-glucosidase (r = 0.49, p &lt; 0.001; r = 0.58, p &lt; 0.01), and gamma-glutamyltransferase (r = 0.49, p &lt; 0.001; r = 0.48, p &lt; 0.001) in seminal plasma.	Dihydrotestosterone	51-54	sucrase-isomaltase	Homo sapiens	94-111
8529412-0	1995	Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor.	Acarbose	62-70	sucrase-isomaltase	Homo sapiens	75-92
8529412-1	1995	Acarbose is an inhibitor of intestinal alpha-glucosidase and has been reported to decrease blood glucose concentrations and glycosuria in diabetic patients and animals.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	39-56
7587923-0	1995	An alpha-glucosidase inhibitor, AO-128, retards carbohydrate absorption in rats and humans.	AO 128	32-38	sucrase-isomaltase	Homo sapiens	3-20
8549017-1	1995	The development of the alpha-glucosidase inhibitor acarbose provides a new approach in the management of diabetes.	Acarbose	51-59	sucrase-isomaltase	Homo sapiens	23-40
8549017-9	1995	Thus, the alpha-glucosidase inhibitor acarbose may have the potential to delay or possibly prevent the development of diabetic complications.	Acarbose	38-46	sucrase-isomaltase	Homo sapiens	10-27
8521759-6	1995	Often, pharmacological treatment of the hyperglycaemia is necessary, in which case sulphonylureas, metformin, alpha-glucosidase inhibitors such as acarbose, or insulin may be employed.	Acarbose	147-155	sucrase-isomaltase	Homo sapiens	110-127
8529510-7	1995	A recent study was designed to evaluate the long-term efficacy of acarbose, an alpha-glucosidase inhibitor, in improving the glycemic control of patients with NIDDM who were sub-optimally controlled on either diet alone, or diet plus sulphonylurea, metformin or insulin.	Acarbose	66-74	sucrase-isomaltase	Homo sapiens	79-96
7589773-1	1995	Twenty patients with non-insulin-dependent diabetes mellitus who had been receiving appropriate dietary treatment for 3 months but whose glucose metabolism needed further improvement were treated with an alpha-glucosidase inhibitor.	Glucose	137-144	sucrase-isomaltase	Homo sapiens	204-221
7587923-0	1995	An alpha-glucosidase inhibitor, AO-128, retards carbohydrate absorption in rats and humans.	Carbohydrates	48-60	sucrase-isomaltase	Homo sapiens	3-20
7587923-3	1995	AO-128, a potent alpha-glucosidase inhibitor, suppressed post-prandial hyperglycemia and hyperinsulinemia in healthy volunteers at a dose of 0.2 mg with each meal.	AO 128	0-6	sucrase-isomaltase	Homo sapiens	17-34
8536820-1	1995	The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics.	Blood Glucose	94-107	sucrase-isomaltase	Homo sapiens	4-21
12228465-0	1995	The Role of Pea Chloroplast [alpha]-Glucosidase in Transitory Starch Degradation.	Starch	62-68	sucrase-isomaltase	Homo sapiens	29-47
12228465-1	1995	Pea chloroplastic [alpha]-glucosidase (EC 3.2.1.20) involved in transitory starch degradation was purified to apparent homogeneity by ion exchange, reactive dye, hydroxylapatite, hydrophobic interaction, and gel filtration column chromatography.	Starch	75-81	sucrase-isomaltase	Homo sapiens	19-37
12228465-1	1995	Pea chloroplastic [alpha]-glucosidase (EC 3.2.1.20) involved in transitory starch degradation was purified to apparent homogeneity by ion exchange, reactive dye, hydroxylapatite, hydrophobic interaction, and gel filtration column chromatography.	Durapatite	162-177	sucrase-isomaltase	Homo sapiens	19-37
7626234-0	1995	Human small intestinal sucrase-isomaltase: different binding patterns for malto- and isomaltooligosaccharides.	malto- and isomaltooligosaccharides	74-109	sucrase-isomaltase	Homo sapiens	23-41
7626234-1	1995	The hydrolysis of maltose and isomaltose and of sucrose and isomaltose at two different catalytic sites of sucrase-isomaltase has been demonstrated.	Maltose	18-25	sucrase-isomaltase	Homo sapiens	107-125
7626234-1	1995	The hydrolysis of maltose and isomaltose and of sucrose and isomaltose at two different catalytic sites of sucrase-isomaltase has been demonstrated.	Isomaltose	30-40	sucrase-isomaltase	Homo sapiens	107-125
7626234-1	1995	The hydrolysis of maltose and isomaltose and of sucrose and isomaltose at two different catalytic sites of sucrase-isomaltase has been demonstrated.	Sucrose	48-55	sucrase-isomaltase	Homo sapiens	107-125
7626234-1	1995	The hydrolysis of maltose and isomaltose and of sucrose and isomaltose at two different catalytic sites of sucrase-isomaltase has been demonstrated.	Isomaltose	60-70	sucrase-isomaltase	Homo sapiens	107-125
12228465-5	1995	This pH modulation of the [alpha]-glucosidase"s activity and stability is the only mechanism known to regulate starch degradative enzymes in leaves.	Starch	111-117	sucrase-isomaltase	Homo sapiens	27-45
12228465-9	1995	The ability of the [alpha]-glucosidase to hydrolyze [alpha]-1,2- and [alpha]-1,3-glucosidic bonds may be vital if these bonds exist in starch granules because they would be barriers to other starch degradative enzymes.	Starch	135-141	sucrase-isomaltase	Homo sapiens	20-38
12228465-9	1995	The ability of the [alpha]-glucosidase to hydrolyze [alpha]-1,2- and [alpha]-1,3-glucosidic bonds may be vital if these bonds exist in starch granules because they would be barriers to other starch degradative enzymes.	Starch	191-197	sucrase-isomaltase	Homo sapiens	20-38
12228465-10	1995	This purified pea chloroplastic [alpha]-glucosidase was demonstrated to initiate attacks on native transitory chloroplastic starch granules.	Starch	124-130	sucrase-isomaltase	Homo sapiens	33-51
7743764-1	1995	alpha-Glucosidase inhibitors such as acarbose improve blood glucose control in diabetes by delaying or reducing carbohydrate absorption.	Acarbose	37-45	sucrase-isomaltase	Homo sapiens	0-17
7743764-1	1995	alpha-Glucosidase inhibitors such as acarbose improve blood glucose control in diabetes by delaying or reducing carbohydrate absorption.	Blood Glucose	54-67	sucrase-isomaltase	Homo sapiens	0-17
7743764-1	1995	alpha-Glucosidase inhibitors such as acarbose improve blood glucose control in diabetes by delaying or reducing carbohydrate absorption.	Carbohydrates	112-124	sucrase-isomaltase	Homo sapiens	0-17
8536820-0	1995	Voglibose (AO-128) is an efficient alpha-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve.	voglibose	0-9	sucrase-isomaltase	Homo sapiens	35-52
8536820-0	1995	Voglibose (AO-128) is an efficient alpha-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve.	AO 128	11-17	sucrase-isomaltase	Homo sapiens	35-52
8536820-1	1995	The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics.	voglibose	32-41	sucrase-isomaltase	Homo sapiens	4-21
8536820-1	1995	The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics.	AO 128	43-49	sucrase-isomaltase	Homo sapiens	4-21
7635034-1	1994	Acarbose (Glucobay-Bayer) is the first in a new class of oral antidiabetic drugs, the alpha-glucosidase inhibitors.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	86-103
8001623-1	1994	The present paper addresses the question how alpha-glucosidase inhibitors affect glucose homeostasis.	Glucose	81-88	sucrase-isomaltase	Homo sapiens	45-62
8001623-4	1994	The slowing of nutrient (i.e. glucose) absorption by therapeutic means (for example, acarbose) could supplement a new approach in the treatment of type 2 diabetics which would utilize the well-preserved insulinotropic activity of GLP-1 in these patients, its glucagon-lowering effect, and its possible inhibition of gastric emptying rates, the latter helping to reduce the requirement for rapid insulin secretory responses as is intended while using alpha-glucosidase inhibitor treatment.	Glucose	30-37	sucrase-isomaltase	Homo sapiens	450-467
8001623-4	1994	The slowing of nutrient (i.e. glucose) absorption by therapeutic means (for example, acarbose) could supplement a new approach in the treatment of type 2 diabetics which would utilize the well-preserved insulinotropic activity of GLP-1 in these patients, its glucagon-lowering effect, and its possible inhibition of gastric emptying rates, the latter helping to reduce the requirement for rapid insulin secretory responses as is intended while using alpha-glucosidase inhibitor treatment.	Acarbose	85-93	sucrase-isomaltase	Homo sapiens	450-467
8001624-2	1994	The mode of action as well as pharmacological and pharmacodynamic properties of selected inhibitors with special regard to the most thoroughly investigated alpha-glucosidase inhibitor acarbose are discussed.	Acarbose	184-192	sucrase-isomaltase	Homo sapiens	156-173
8001624-4	1994	Therefore, the mechanism of alpha-glucosidase inhibition represents the pharmacological optimization of the dietary principle of delayed carbohydrate absorption.	Carbohydrates	137-149	sucrase-isomaltase	Homo sapiens	28-45
8001628-1	1994	This paper summarizes literature data concerning the action of acarbose, an alpha-glucosidase inhibitor, on the concentrations of plasma lipids.	Acarbose	63-71	sucrase-isomaltase	Homo sapiens	76-93
7818725-0	1994	Reduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.	Metformin	42-51	sucrase-isomaltase	Homo sapiens	59-76
7818725-0	1994	Reduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.	Acarbose	87-95	sucrase-isomaltase	Homo sapiens	59-76
7818725-1	1994	In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin.	Acarbose	108-116	sucrase-isomaltase	Homo sapiens	80-97
7818725-1	1994	In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin.	Biguanides	147-156	sucrase-isomaltase	Homo sapiens	80-97
7818725-1	1994	In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin.	Metformin	166-175	sucrase-isomaltase	Homo sapiens	80-97
8141777-5	1994	In contrast, SGLT1, GLUT2 and GLUT5 mRNAs were only expressed, like sucrase-isomaltase mRNA, in the low-glucose-consuming clones, and their level increased from the exponential to the stationary phase, in parallel with the differentiation of the cells.	Glucose	104-111	sucrase-isomaltase	Homo sapiens	68-86
8033575-7	1994	A significantly higher release of alpha-glucosidase and alpha-mannosidase was noted in those corneas stored in Optisol containing both hEGF and insulin.	Optisol	111-118	sucrase-isomaltase	Homo sapiens	34-51
8137734-6	1994	In contrast, 1,25-(OH)2D3 inhibited the normal rise in sucrase-isomaltase activity and the corresponding mRNA level, although the inhibition occurred after the initial period of cell differentiation (&gt; 10 days postplating).	Calcitriol	13-25	sucrase-isomaltase	Homo sapiens	55-73
7508390-4	1994	Forskolin induced lactase-phlorizin hydrolase synthesis approximately fourfold within 7 h, suppressed sucrase-isomaltase synthesis, and had little effect on dipeptidylpeptidase IV.	Colforsin	0-9	sucrase-isomaltase	Homo sapiens	102-120
7508390-7	1994	Phorbol 12-myristate 13-acetate had an inhibitory effect on brush-border enzyme synthesis, in particular on sucrase-isomaltase, and blocked the forskolin-induced biosynthesis of lactase-phlorizin hydrolase.	Tetradecanoylphorbol Acetate	0-31	sucrase-isomaltase	Homo sapiens	108-126
7508390-9	1994	The results indicate opposite regulation of lactase-phlorizin hydrolase and sucrase-isomaltase via cAMP and corticosteroids, and suggest that the Caco-2 cell line can serve as a model system to study aspects of the humoral regulation of human intestinal brush-border enzymes in cell culture.	Cyclic AMP	99-103	sucrase-isomaltase	Homo sapiens	76-94
8102104-0	1993	Monensin and forskolin inhibit the transcription rate of sucrase-isomaltase but not the stability of its mRNA in Caco-2 cells.	Colforsin	13-22	sucrase-isomaltase	Homo sapiens	57-75
8175910-0	1994	Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation.	Glucose	132-139	sucrase-isomaltase	Homo sapiens	27-45
8175910-1	1994	The expression of the brush border-associated hydrolase sucrase-isomaltase was shown to increase from early to late passages of Caco-2 cells, concomitant with a decrease in the rates of glucose consumption.	Glucose	186-193	sucrase-isomaltase	Homo sapiens	56-74
8175910-4	1994	Clones with low sucrase-isomaltase expression show a mosaic expression of the enzyme and a 38-fold higher rate of glucose consumption than clones with high sucrase-isomaltase expression.	Glucose	114-121	sucrase-isomaltase	Homo sapiens	16-34
8175910-7	1994	Switch to low glucose-containing medium (1 mM versus 25 mM in standard culture conditions) of cells with low sucrase-isomaltase results in an increased and more homogeneous expression of the enzyme and a tenfold augmentation of the levels of sucrase-isomaltase mRNA and sucrase activity.	Glucose	14-21	sucrase-isomaltase	Homo sapiens	109-127
8175910-7	1994	Switch to low glucose-containing medium (1 mM versus 25 mM in standard culture conditions) of cells with low sucrase-isomaltase results in an increased and more homogeneous expression of the enzyme and a tenfold augmentation of the levels of sucrase-isomaltase mRNA and sucrase activity.	Glucose	14-21	sucrase-isomaltase	Homo sapiens	242-260
8175910-8	1994	These results show that glucose interferes with the expression of sucrase-isomaltase in Caco-2 cells at the mRNA level.	Glucose	24-31	sucrase-isomaltase	Homo sapiens	66-84
8026606-8	1993	Alpha-glucosidase inhibitors may help to reduce post-prandial glucose excursions but do not promote weight loss per se.	Glucose	62-69	sucrase-isomaltase	Homo sapiens	0-17
8102104-1	1993	Treatment of Caco-2 cells with forskolin (25 microM) or monensin (1 microM) has previously been shown to cause a marked decrease in the level of sucrase-isomaltase (SI) mRNA, without any effect on the expression of dipeptidylpeptidase IV (DPP-IV).	Colforsin	31-40	sucrase-isomaltase	Homo sapiens	145-163
8102104-1	1993	Treatment of Caco-2 cells with forskolin (25 microM) or monensin (1 microM) has previously been shown to cause a marked decrease in the level of sucrase-isomaltase (SI) mRNA, without any effect on the expression of dipeptidylpeptidase IV (DPP-IV).	Colforsin	31-40	sucrase-isomaltase	Homo sapiens	165-167
8102104-3	1993	On the other hand, we demonstrate a decrease in the transcription rate of SI mRNA which is sufficient to account for the decrease in the steady-state level of SI mRNA both in forskolin- and monensin-treated Caco-2 cells.	Colforsin	175-184	sucrase-isomaltase	Homo sapiens	74-76
8102104-3	1993	On the other hand, we demonstrate a decrease in the transcription rate of SI mRNA which is sufficient to account for the decrease in the steady-state level of SI mRNA both in forskolin- and monensin-treated Caco-2 cells.	Colforsin	175-184	sucrase-isomaltase	Homo sapiens	159-161
8212978-4	1993	Oral drug therapies include sulphonylurea derivatives, biguanides, among which metformin remains the only one commercialized in our country, and alpha-glucosidase inhibitors such as acarbose.	Acarbose	182-190	sucrase-isomaltase	Homo sapiens	145-162
8411709-1	1993	The importance of the role of acid alpha-glucosidase in the lysosomal degradation of glycogen has been emphasized because the deficiency of this enzyme in glycogenosis type II causes glycogen accumulation in lysosomes.	Glycogen	85-93	sucrase-isomaltase	Homo sapiens	35-52
8411709-1	1993	The importance of the role of acid alpha-glucosidase in the lysosomal degradation of glycogen has been emphasized because the deficiency of this enzyme in glycogenosis type II causes glycogen accumulation in lysosomes.	Glycogen	155-163	sucrase-isomaltase	Homo sapiens	35-52
8478269-0	1993	Pradimicin Q, a new pradimicin aglycone, with alpha-glucosidase inhibitory activity.	CHEBI:166892	31-39	sucrase-isomaltase	Homo sapiens	46-63
1430211-6	1992	Rifampin treatment resulted in a five- or eightfold mean increase (P &lt; 0.05) in the biopsy concentration of P450IIIA4 mRNA when normalized for content of sucrase isomaltase or intestinal fatty acid binding protein mRNAs, respectively.	Rifampin	0-8	sucrase-isomaltase	Homo sapiens	157-175
8441762-7	1993	At high glucose, however, a partial inhibition of both insulin release (approximately 50%) and acid alpha-glucosidase activity was seen.	Glucose	8-15	sucrase-isomaltase	Homo sapiens	100-117
8441762-9	1993	Direct addition of glucose to islet homogenates showed a suppressive effect on alpha-glucosidase activity at pH 4.0 and 5.0.	Glucose	19-26	sucrase-isomaltase	Homo sapiens	79-96
8441762-10	1993	The glucose analogues displayed only marginal (-10%) inhibition of alpha-glucosidase activity at pH 5.0.	Glucose	4-11	sucrase-isomaltase	Homo sapiens	67-84
1481998-3	1992	The results of the specific actions of alpha- and beta-glucosidases showed that the non-dialysable urinary glucoconjugates contain a branched alpha-glucan fraction with 1,4- and 1,6-glucosidic bonds, and a beta-glucan fraction containing 1,4-glucosidic bonds.	alpha-glucan	142-154	sucrase-isomaltase	Homo sapiens	39-67
1481998-3	1992	The results of the specific actions of alpha- and beta-glucosidases showed that the non-dialysable urinary glucoconjugates contain a branched alpha-glucan fraction with 1,4- and 1,6-glucosidic bonds, and a beta-glucan fraction containing 1,4-glucosidic bonds.	beta-Glucans	206-217	sucrase-isomaltase	Homo sapiens	39-67
1324837-9	1992	Enzyme activity measurements and immunoprecipitation of metabolically labeled cells showed that incubation with NH4Cl leads to an enhanced secretion of these enzymes into the basolateral medium, but has no effect on the basolateral secretion of alpha-glucosidase.	Ammonium Chloride	112-117	sucrase-isomaltase	Homo sapiens	245-262
1427379-6	1992	These results indicate that alpha-glucosidase inhibitors accelerate mouth to caecum transit time by inducing carbohydrate malabsorption.	Carbohydrates	109-121	sucrase-isomaltase	Homo sapiens	28-45
1552361-5	1992	In addition, AA-2G-induced stimulation of collagen synthesis could be completely inhibited by the addition of castanospermine, an inhibitor of neutral alpha-glucosidase.	castanospermine	110-125	sucrase-isomaltase	Homo sapiens	151-168
1552361-6	1992	Relatively high alpha-glucosidase activity, which would contribute to release of ascorbic acid from AA-2G, could be detected in the lysate of cultured fibroblasts.	Ascorbic Acid	81-94	sucrase-isomaltase	Homo sapiens	16-33
1552361-9	1992	These results indicate that AA-2G is gradually cleaved by the cellular alpha-glucosidase to release L-ascorbic acid, which adequately stimulates collagen synthesis and proliferation of human skin fibroblasts.	Ascorbic Acid	100-115	sucrase-isomaltase	Homo sapiens	71-88
1280577-0	1992	Safety profile of acarbose, an alpha-glucosidase inhibitor.	Acarbose	18-26	sucrase-isomaltase	Homo sapiens	31-48
1499461-1	1992	OBJECTIVE: To determine the efficacy of the alpha-glucosidase inhibitor miglitol (BAYm 1099) regarding the starch content of food.	miglitol	72-80	sucrase-isomaltase	Homo sapiens	44-61
1499461-1	1992	OBJECTIVE: To determine the efficacy of the alpha-glucosidase inhibitor miglitol (BAYm 1099) regarding the starch content of food.	miglitol	82-91	sucrase-isomaltase	Homo sapiens	44-61
1499461-1	1992	OBJECTIVE: To determine the efficacy of the alpha-glucosidase inhibitor miglitol (BAYm 1099) regarding the starch content of food.	Starch	107-113	sucrase-isomaltase	Homo sapiens	44-61
1363580-3	1992	The alpha-glucosidase, mannosidase and arylsulfatase-A enzyme activities significantly diminished if homogenization was done in saline instead of Triton-X while the difference in fucosidase activity was not significant.	Sodium Chloride	128-134	sucrase-isomaltase	Homo sapiens	4-21
1363580-3	1992	The alpha-glucosidase, mannosidase and arylsulfatase-A enzyme activities significantly diminished if homogenization was done in saline instead of Triton-X while the difference in fucosidase activity was not significant.	Octoxynol	146-154	sucrase-isomaltase	Homo sapiens	4-21
1541004-1	1992	Using different conditions for incubation and fluorometry with 4-methylumbelliferylglycosides as substrates, we demonstrated the presence of acid alpha-glucosidase, "renal" alpha-glucosidase, N-acetyl-beta-D-glucosaminidase A, and N-acetyl-beta-D-glucosaminidase B in freshly drawn normal human serum.	4-methylumbelliferyl glycosides	63-93	sucrase-isomaltase	Homo sapiens	146-163
1541004-1	1992	Using different conditions for incubation and fluorometry with 4-methylumbelliferylglycosides as substrates, we demonstrated the presence of acid alpha-glucosidase, "renal" alpha-glucosidase, N-acetyl-beta-D-glucosaminidase A, and N-acetyl-beta-D-glucosaminidase B in freshly drawn normal human serum.	4-methylumbelliferyl glycosides	63-93	sucrase-isomaltase	Homo sapiens	173-190
1541004-2	1992	The acid alpha-glucosidase enzymatic activity was determined at pH 4.0 in 0.1 mol/L Tris reagent, whereas the renal isoenzyme activity was determined at pH 5.6 in presence of 0.05 mol/L turanose reagent.	Tromethamine	84-88	sucrase-isomaltase	Homo sapiens	9-26
1280573-2	1992	The alpha-glucosidase inhibitor, acarbose, should be taken with meals that are rich in complex carbohydrates and low in simple sugars, as recommended by diabetes associations, to achieve the greatest possible benefit from treatment.	Acarbose	33-41	sucrase-isomaltase	Homo sapiens	4-21
1280573-2	1992	The alpha-glucosidase inhibitor, acarbose, should be taken with meals that are rich in complex carbohydrates and low in simple sugars, as recommended by diabetes associations, to achieve the greatest possible benefit from treatment.	Carbohydrates	95-108	sucrase-isomaltase	Homo sapiens	4-21
1280573-2	1992	The alpha-glucosidase inhibitor, acarbose, should be taken with meals that are rich in complex carbohydrates and low in simple sugars, as recommended by diabetes associations, to achieve the greatest possible benefit from treatment.	Sugars	127-133	sucrase-isomaltase	Homo sapiens	4-21
1280574-6	1992	alpha-Glucosidase inhibitors, a new class of drugs that delay carbohydrate digestion and absorption, reduce postprandial glycaemic rises by about 3 mmol/L.	Carbohydrates	62-74	sucrase-isomaltase	Homo sapiens	0-17
1280577-1	1992	Acarbose, an alpha-glucosidase inhibitor, delays absorption of carbohydrate in the gut, thereby lowering postprandial glucose levels.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
1280577-1	1992	Acarbose, an alpha-glucosidase inhibitor, delays absorption of carbohydrate in the gut, thereby lowering postprandial glucose levels.	Carbohydrates	63-75	sucrase-isomaltase	Homo sapiens	13-30
1280577-1	1992	Acarbose, an alpha-glucosidase inhibitor, delays absorption of carbohydrate in the gut, thereby lowering postprandial glucose levels.	Glucose	118-125	sucrase-isomaltase	Homo sapiens	13-30
1771945-1	1991	The alpha-glucosidase inhibitor acarbose induces a reversible delay of carbohydrate digestion.	Acarbose	32-40	sucrase-isomaltase	Homo sapiens	4-21
1523353-1	1992	Oral acarbose, a competitive inhibitor of alpha-glucosidase, has been shown to be effective in decreasing the postprandial rise in blood glucose and insulin.	Acarbose	5-13	sucrase-isomaltase	Homo sapiens	42-59
24425332-2	1992	The specific activity of alpha-glucosidase depended on the dilution rate as well as the proportion of maltose in the mixture.	Maltose	102-109	sucrase-isomaltase	Homo sapiens	25-42
24425332-3	1992	The chemostat provides a way of reaching the low residual concentrations of glucose in the broth that are necessary to release catabolite repression and permit maltose induction of alpha-glucosidase.	Glucose	76-83	sucrase-isomaltase	Homo sapiens	181-198
24425332-3	1992	The chemostat provides a way of reaching the low residual concentrations of glucose in the broth that are necessary to release catabolite repression and permit maltose induction of alpha-glucosidase.	Maltose	160-167	sucrase-isomaltase	Homo sapiens	181-198
1684938-0	1991	Decrease of mRNA levels and biosynthesis of sucrase-isomaltase but not dipeptidylpeptidase IV in forskolin or monensin-treated Caco-2 cells.	Colforsin	97-106	sucrase-isomaltase	Homo sapiens	44-62
1684938-0	1991	Decrease of mRNA levels and biosynthesis of sucrase-isomaltase but not dipeptidylpeptidase IV in forskolin or monensin-treated Caco-2 cells.	Monensin	110-118	sucrase-isomaltase	Homo sapiens	44-62
1684938-1	1991	Treatment for 48 h of differentiated, confluent Caco-2 cells with 2.5 10(-5) M forskolin or 10(-6) M monensin, which produces a significant decrease of the de novo biosynthesis of sucrase-isomaltase, does not change quantitatively the de novo biosynthesis of dipeptidylpeptidase IV.	Colforsin	79-88	sucrase-isomaltase	Homo sapiens	180-198
1684938-4	1991	In contrast, forskolin and monensin dramatically decrease the level of sucrase-isomaltase mRNA.	Colforsin	13-22	sucrase-isomaltase	Homo sapiens	71-89
1527988-0	1992	Tris discriminates between the different alpha-glucosidase activities from extracts of human neutrophils.	Tromethamine	0-4	sucrase-isomaltase	Homo sapiens	41-58
1527988-4	1992	Our results demonstrate that 0.1 mol/L Tris is an inhibitor of the renal alpha-glucosidase present in neutrophils and can be used to reduce the interference from this enzyme in assays of acid maltase.	Tromethamine	39-43	sucrase-isomaltase	Homo sapiens	73-90
1842749-6	1991	Alpha-glucosidase inhibition to prevent post-prandial glycaemia may have a role in patients in whom sulphonylurea or diet therapy has been used to obtain normal basal glucose concentrations.	Glucose	167-174	sucrase-isomaltase	Homo sapiens	0-17
1771945-1	1991	The alpha-glucosidase inhibitor acarbose induces a reversible delay of carbohydrate digestion.	Carbohydrates	71-83	sucrase-isomaltase	Homo sapiens	4-21
1656521-2	1991	In this study we compared the efficacy of a "musli" with the alpha-glucosidase inhibitor miglitol in delaying the resorption of carbohydrates.	Carbohydrates	128-141	sucrase-isomaltase	Homo sapiens	61-78
1717481-6	1991	The first phenotype revealed a sucrase-isomaltase protein that is synthesized as a single chain, mannose-rich polypeptide precursor (pro-SI) and is electrophoretically indistinguishable from pro-SI in normal controls.	Mannose	97-104	sucrase-isomaltase	Homo sapiens	31-49
1656521-8	1991	This study shows that the alpha-glucosidase inhibitor miglitol in a dose of 100 mg is more effective in lowering the postprandial blood glucose increase than a musli.	Blood Glucose	130-143	sucrase-isomaltase	Homo sapiens	26-43
1656521-9	1991	In cases of non-acceptance of a modern diet with slowly resorbable carbohydrates, alpha-glucosidase inhibitors may be a therapeutic alternative.	Carbohydrates	67-80	sucrase-isomaltase	Homo sapiens	82-99
1934499-2	1991	Under this alpha-amylase assay condition, 3KB-CNPG5 is resistant to glucoamylase and alpha-glucosidase, which are auxiliary enzymes, because the 4- and 6-positions of the non-reducing-end glucose residue are modified by the 3-ketobutylidene group.	3-ketobutylidene	224-240	sucrase-isomaltase	Homo sapiens	85-102
1868444-4	1991	During a double-blind crossover trial they received the alpha-glucosidase inhibitor acarbose (BAY g 5421) in one of the study periods and placebo in the other.	Acarbose	84-92	sucrase-isomaltase	Homo sapiens	56-73
1934499-2	1991	Under this alpha-amylase assay condition, 3KB-CNPG5 is resistant to glucoamylase and alpha-glucosidase, which are auxiliary enzymes, because the 4- and 6-positions of the non-reducing-end glucose residue are modified by the 3-ketobutylidene group.	Glucose	188-195	sucrase-isomaltase	Homo sapiens	85-102
2060451-0	1991	Effects of alpha-glucosidase inhibition on meal glucose tolerance and timing of insulin administration in patients with type I diabetes mellitus.	Glucose	48-55	sucrase-isomaltase	Homo sapiens	11-28
2060451-1	1991	OBJECTIVE: Miglitol, an alpha-glucosidase inhibitor, delays absorption of carbohydrates.	Carbohydrates	74-87	sucrase-isomaltase	Homo sapiens	24-41
1952121-3	1991	We compared the spermatozoal ATP concentration and alpha-glucosidase activity in semen of patients with DCTs to that of a control group.	dcts	104-108	sucrase-isomaltase	Homo sapiens	51-68
1952121-4	1991	Higher ATP concentration and lower alpha-glucosidase activity were found in patients with DCTs in their semen compared to the control group.	dcts	90-94	sucrase-isomaltase	Homo sapiens	35-52
1784628-0	1991	Inhibition of glycemic and hormonal responses after repetitive sucrose and starch loads by different doses of the alpha-glucosidase inhibitor miglitol (BAY m 1099) in man.	miglitol	142-150	sucrase-isomaltase	Homo sapiens	114-131
1671558-3	1991	The retardation of sucrase-isomaltase, a slowly migrating hydrolase, versus dipeptidylpeptidase IV, a rapidly transported enzyme, is neither due to differential trimming of N-linked carbohydrates nor due to oligomerization.	n-linked carbohydrates	173-195	sucrase-isomaltase	Homo sapiens	19-37
1815967-0	1991	Inhibition of sucrose- and starch-induced glycaemic and hormonal responses by the alpha-glucosidase inhibitor emiglitate (BAY o 1248) in healthy volunteers.	Sucrose	14-21	sucrase-isomaltase	Homo sapiens	82-99
1815967-0	1991	Inhibition of sucrose- and starch-induced glycaemic and hormonal responses by the alpha-glucosidase inhibitor emiglitate (BAY o 1248) in healthy volunteers.	Starch	27-33	sucrase-isomaltase	Homo sapiens	82-99
1815967-0	1991	Inhibition of sucrose- and starch-induced glycaemic and hormonal responses by the alpha-glucosidase inhibitor emiglitate (BAY o 1248) in healthy volunteers.	emiglitate	122-132	sucrase-isomaltase	Homo sapiens	82-99
1815967-3	1991	Flattening of postprandial responses of blood glucose, serum insulin and gastric inhibitory polypeptide was still apparent after a second sucrose load 4 h later, demonstrating long-lasting inhibition of alpha-glucosidase activity.	Sucrose	138-145	sucrase-isomaltase	Homo sapiens	203-220
1815967-7	1991	Breath hydrogen concentration increased gradually, indicating slight but significant carbohydrate malabsorption after the highest dose of the alpha-glucosidase inhibitor.	Hydrogen	7-15	sucrase-isomaltase	Homo sapiens	142-159
1815967-7	1991	Breath hydrogen concentration increased gradually, indicating slight but significant carbohydrate malabsorption after the highest dose of the alpha-glucosidase inhibitor.	Carbohydrates	85-97	sucrase-isomaltase	Homo sapiens	142-159
1784628-0	1991	Inhibition of glycemic and hormonal responses after repetitive sucrose and starch loads by different doses of the alpha-glucosidase inhibitor miglitol (BAY m 1099) in man.	miglitol	152-162	sucrase-isomaltase	Homo sapiens	114-131
1784628-3	1991	This effect was dose-dependent and confined to the first carbohydrate load in the morning, thus indicating the duration of alpha-glucosidase inhibition of less than 4 h. Sucrose malabsorption, indicated by breath hydrogen responses, occurred dose-dependently with 50 and 100 mg, but not with 25 mg of miglitol.	Carbohydrates	57-69	sucrase-isomaltase	Homo sapiens	123-140
1784628-3	1991	This effect was dose-dependent and confined to the first carbohydrate load in the morning, thus indicating the duration of alpha-glucosidase inhibition of less than 4 h. Sucrose malabsorption, indicated by breath hydrogen responses, occurred dose-dependently with 50 and 100 mg, but not with 25 mg of miglitol.	Sucrose	170-177	sucrase-isomaltase	Homo sapiens	123-140
1784628-3	1991	This effect was dose-dependent and confined to the first carbohydrate load in the morning, thus indicating the duration of alpha-glucosidase inhibition of less than 4 h. Sucrose malabsorption, indicated by breath hydrogen responses, occurred dose-dependently with 50 and 100 mg, but not with 25 mg of miglitol.	Hydrogen	213-221	sucrase-isomaltase	Homo sapiens	123-140
1784628-3	1991	This effect was dose-dependent and confined to the first carbohydrate load in the morning, thus indicating the duration of alpha-glucosidase inhibition of less than 4 h. Sucrose malabsorption, indicated by breath hydrogen responses, occurred dose-dependently with 50 and 100 mg, but not with 25 mg of miglitol.	miglitol	301-309	sucrase-isomaltase	Homo sapiens	123-140
2256108-2	1990	Leucocyte alpha-glucosidase showed optimal activity towards all four oligosaccharides under two conditions, acidic (pH 4.0-4.5) and neutral (pH 6.0-6.5) regions.	Oligosaccharides	69-85	sucrase-isomaltase	Homo sapiens	10-27
2223417-2	1990	Alpha-glucosidase inhibitors such as miglitol and acarbose lower blood glucose after a starch load in healthy volunteers and diabetic patients by interfering with the conversion of disaccharide to monosaccharide in the gastrointestinal tract.	Starch	87-93	sucrase-isomaltase	Homo sapiens	0-17
2223417-2	1990	Alpha-glucosidase inhibitors such as miglitol and acarbose lower blood glucose after a starch load in healthy volunteers and diabetic patients by interfering with the conversion of disaccharide to monosaccharide in the gastrointestinal tract.	Disaccharides	181-193	sucrase-isomaltase	Homo sapiens	0-17
2223417-2	1990	Alpha-glucosidase inhibitors such as miglitol and acarbose lower blood glucose after a starch load in healthy volunteers and diabetic patients by interfering with the conversion of disaccharide to monosaccharide in the gastrointestinal tract.	Monosaccharides	197-211	sucrase-isomaltase	Homo sapiens	0-17
2223417-2	1990	Alpha-glucosidase inhibitors such as miglitol and acarbose lower blood glucose after a starch load in healthy volunteers and diabetic patients by interfering with the conversion of disaccharide to monosaccharide in the gastrointestinal tract.	Blood Glucose	65-78	sucrase-isomaltase	Homo sapiens	0-17
2256108-4	1990	Acid alpha-glucosidase could hydrolyze maltose about 10 times faster than isomaltose, and maltotetraose about 5 times faster than tetrasaccharide isolated from urine.	Maltose	39-46	sucrase-isomaltase	Homo sapiens	5-22
2256108-4	1990	Acid alpha-glucosidase could hydrolyze maltose about 10 times faster than isomaltose, and maltotetraose about 5 times faster than tetrasaccharide isolated from urine.	Isomaltose	74-84	sucrase-isomaltase	Homo sapiens	5-22
2256108-4	1990	Acid alpha-glucosidase could hydrolyze maltose about 10 times faster than isomaltose, and maltotetraose about 5 times faster than tetrasaccharide isolated from urine.	tetrasaccharide	130-145	sucrase-isomaltase	Homo sapiens	5-22
2256108-5	1990	In leucocytes of the patient with late onset glycogenosis type II, acid alpha-glucosidase activities towards maltose, isomaltose, maltotetraose and tetrasaccharide isolated from urine showed 75.3%, 67.4%, 76.5% and 41.4% of normal control values, respectively.	Maltose	109-116	sucrase-isomaltase	Homo sapiens	72-89
2256108-5	1990	In leucocytes of the patient with late onset glycogenosis type II, acid alpha-glucosidase activities towards maltose, isomaltose, maltotetraose and tetrasaccharide isolated from urine showed 75.3%, 67.4%, 76.5% and 41.4% of normal control values, respectively.	Isomaltose	118-128	sucrase-isomaltase	Homo sapiens	72-89
2256108-5	1990	In leucocytes of the patient with late onset glycogenosis type II, acid alpha-glucosidase activities towards maltose, isomaltose, maltotetraose and tetrasaccharide isolated from urine showed 75.3%, 67.4%, 76.5% and 41.4% of normal control values, respectively.	maltotetraose	130-143	sucrase-isomaltase	Homo sapiens	72-89
2256108-5	1990	In leucocytes of the patient with late onset glycogenosis type II, acid alpha-glucosidase activities towards maltose, isomaltose, maltotetraose and tetrasaccharide isolated from urine showed 75.3%, 67.4%, 76.5% and 41.4% of normal control values, respectively.	tetrasaccharide	148-163	sucrase-isomaltase	Homo sapiens	72-89
2256108-6	1990	Neutral alpha-glucosidase activities towards these four oligosaccharides were normal.	Oligosaccharides	56-72	sucrase-isomaltase	Homo sapiens	8-25
2261891-5	1990	Data from this study suggest that seasonal variations of testosterone in adult rams exert a negative control on the presence of alpha-glucosidase in semen.	Testosterone	57-69	sucrase-isomaltase	Homo sapiens	128-145
2200520-0	1990	Formation of a stable L-ascorbic acid alpha-glucoside by mammalian alpha-glucosidase-catalyzed transglucosylation.	l-ascorbic acid alpha-glucoside	22-53	sucrase-isomaltase	Homo sapiens	67-84
2200520-5	1990	These properties were very different from those of AA and L-ascorbic acid alpha-glucoside formed with alpha-glucosidase from A. niger, but they were consistent with those of L-ascorbic acid 2-O-phosphate and L-ascorbic acid 2-O-sulfate.	l-ascorbic acid alpha-glucoside	58-89	sucrase-isomaltase	Homo sapiens	102-119
1692546-3	1990	Colonic sucrase-isomaltase was purified by immunoprecipitation with selected monoclonal antibodies and identified predominantly as high-mannose and complex glycosylated single-chain precursors endowed with relatively low levels of enzyme activities.	Mannose	136-143	sucrase-isomaltase	Homo sapiens	8-26
33779055-0	2021	Natural triterpenoids isolated from Akebia trifoliata Stem Explants exerts hypoglycemic effect via inhibits alpha-glucosidase and stimulates glucose uptake in insulin-resistance HepG2 cells.	Triterpenes	8-21	sucrase-isomaltase	Homo sapiens	108-125
33766763-0	2021	Dibenzazepine-linked isoxazoles: New and potent class of alpha-glucosidase inhibitors.	dibenzazepine	0-13	sucrase-isomaltase	Homo sapiens	57-74
33766763-0	2021	Dibenzazepine-linked isoxazoles: New and potent class of alpha-glucosidase inhibitors.	linked	14-20	sucrase-isomaltase	Homo sapiens	57-74
33766763-0	2021	Dibenzazepine-linked isoxazoles: New and potent class of alpha-glucosidase inhibitors.	Isoxazoles	21-31	sucrase-isomaltase	Homo sapiens	57-74
33766763-3	2021	For this, a series of dibenzazepine-linked isoxazoles (33-54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their alpha-glucosidase inhibitory activities to explore new hits for treatment of diabetes.	dibenzazepine	22-35	sucrase-isomaltase	Homo sapiens	157-174
33766763-3	2021	For this, a series of dibenzazepine-linked isoxazoles (33-54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their alpha-glucosidase inhibitory activities to explore new hits for treatment of diabetes.	Isoxazoles	43-53	sucrase-isomaltase	Homo sapiens	157-174
33766763-4	2021	Most of the compounds showed potent inhibitory potency against alpha-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 +- 1.48 to 333.30 +- 1.67 microM) using acarbose as a reference drug (IC50 = 875.75 +- 2.08 microM).	Acarbose	156-164	sucrase-isomaltase	Homo sapiens	63-80
33779055-3	2021	The results indicated that three triterpenoids exhibited excellent inhibitory activities against alpha-glucosidase.	Triterpenes	33-46	sucrase-isomaltase	Homo sapiens	97-114
33779055-7	2021	Docking analysis determined the interaction of compounds ( 1-3 ) and alpha-glucosidase was mainly forced by hydrogen bonds and hydrophobic interaction, which could be effectively inserted into the active pocket of alpha-glucosidase.	Hydrogen	108-116	sucrase-isomaltase	Homo sapiens	69-86
33779055-7	2021	Docking analysis determined the interaction of compounds ( 1-3 ) and alpha-glucosidase was mainly forced by hydrogen bonds and hydrophobic interaction, which could be effectively inserted into the active pocket of alpha-glucosidase.	Hydrogen	108-116	sucrase-isomaltase	Homo sapiens	214-231
33779055-9	2021	These triterpenoids exhibited dual therapeutic effects of alpha-glucosidase inhibition and glucose uptake promotion, thus they could be used as antidiabetic agents for developing novel drugs against type 2 diabetes.	Triterpenes	6-19	sucrase-isomaltase	Homo sapiens	58-75
33817815-0	2021	Preparation and characterization of metal-tea polysaccharide complexes and their inhibition on alpha-glucosidase.	metal-tea	36-45	sucrase-isomaltase	Homo sapiens	95-112
33812564-0	2021	Preparation of phytic acid modified alpha-Glucosidase/Cu3(PO4)2 3H2O hybrid nanoflower and its application.	Phytic Acid	15-26	sucrase-isomaltase	Homo sapiens	36-53
33812564-1	2021	A simple, convenient and efficient enzyme immobilization method through phytic acid (PA) modified alpha-Glucosidase (alpha-Glu)/Cu3(PO4)2 3H2O hybrid nanoflower was developed.	Phytic Acid	72-83	sucrase-isomaltase	Homo sapiens	98-115
33812564-1	2021	A simple, convenient and efficient enzyme immobilization method through phytic acid (PA) modified alpha-Glucosidase (alpha-Glu)/Cu3(PO4)2 3H2O hybrid nanoflower was developed.	Phytic Acid	85-87	sucrase-isomaltase	Homo sapiens	98-115
33817815-0	2021	Preparation and characterization of metal-tea polysaccharide complexes and their inhibition on alpha-glucosidase.	Polysaccharides	46-60	sucrase-isomaltase	Homo sapiens	95-112
33817815-6	2021	The inhibitory activity of Fe-TPS on alpha-glucosidase was lower than that without Fe.	fe-tps	27-33	sucrase-isomaltase	Homo sapiens	37-54
33817815-6	2021	The inhibitory activity of Fe-TPS on alpha-glucosidase was lower than that without Fe.	Iron	27-29	sucrase-isomaltase	Homo sapiens	37-54
33817806-0	2022	Identification of curcumin as a potential alpha-glucosidase and dipeptidyl-peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation.	Curcumin	18-26	sucrase-isomaltase	Homo sapiens	42-59
33817806-3	2022	The results indicated that curcumin is an inhibitor of both alpha-glucosidase and dipeptidyl-peptidase 4 (DPP-4), which are important for glycemic control.	Curcumin	27-35	sucrase-isomaltase	Homo sapiens	60-77
33765238-7	2022	Sterols 2-3 and flavonoid 11 induced the IC50 values of < 2.0 microg/mL better than the positive control acarbose (IC50 = 184.0 microg/mL) in alpha-glucosidase inhibitory assay.	Sterols	0-7	sucrase-isomaltase	Homo sapiens	142-159
33765180-8	2021	In meta-analyses of glucose-lowering drugs, the risk ratio for stroke was 0.85 (0.77, 0.94) for glucagon-like peptide-1 receptor agonists and 0.82 (0.69, 0.98) for thiazolidinediones, while sulfonylureas, dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter 2 inhibitors, alpha-glucosidase inhibitors, meglitinides and metformin individually lacked statistical evidence of an effect on stroke risk.	Glucose	20-27	sucrase-isomaltase	Homo sapiens	283-300
33765238-7	2022	Sterols 2-3 and flavonoid 11 induced the IC50 values of < 2.0 microg/mL better than the positive control acarbose (IC50 = 184.0 microg/mL) in alpha-glucosidase inhibitory assay.	Flavonoids	16-25	sucrase-isomaltase	Homo sapiens	142-159
33765238-7	2022	Sterols 2-3 and flavonoid 11 induced the IC50 values of < 2.0 microg/mL better than the positive control acarbose (IC50 = 184.0 microg/mL) in alpha-glucosidase inhibitory assay.	Acarbose	105-113	sucrase-isomaltase	Homo sapiens	142-159
34624776-0	2022	Understanding phenolic acids inhibition of alpha-amylase and alpha-glucosidase and influence of reaction conditions.	phenolic acid	14-28	sucrase-isomaltase	Homo sapiens	61-78
33804322-8	2021	C3G could spontaneously bind with alpha-glucosidase to form complexes by hydrogen bonds.	Hydrogen	73-81	sucrase-isomaltase	Homo sapiens	34-51
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Hydrogen	49-57	sucrase-isomaltase	Homo sapiens	69-86
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Leucine	117-120	sucrase-isomaltase	Homo sapiens	69-86
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Phenylalanine	144-147	sucrase-isomaltase	Homo sapiens	69-86
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Arginine	153-156	sucrase-isomaltase	Homo sapiens	69-86
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Aspartic Acid	170-173	sucrase-isomaltase	Homo sapiens	69-86
17515447-0	2007	Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure.	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	13-30
17515447-3	2007	We hypothesized that acarbose, an alpha-glucosidase inhibitor that decreases glucose absorption in the small intestine, would attenuate postprandial hypotension.	Acarbose	21-29	sucrase-isomaltase	Homo sapiens	34-51
34624776-2	2022	The potential inhibition of nine phenolic acids against alpha-amylase and alpha-glucosidase was studied applying different methodologies to understand interactions between phenolic acids and either enzymes or substrates.	phenolic acid	33-47	sucrase-isomaltase	Homo sapiens	74-91
34624776-6	2022	Those effects were not really evident with alpha-glucosidase, likely due to the small molecular size of maltose substrate.	Maltose	104-111	sucrase-isomaltase	Homo sapiens	43-60
34624776-7	2022	Phenolic acids with > 1 hydroxyl group like caffeic and protocatechuic acids showed the lowest IC50 against alpha-glucosidase.	phenolic acid	0-14	sucrase-isomaltase	Homo sapiens	108-125
34624776-7	2022	Phenolic acids with > 1 hydroxyl group like caffeic and protocatechuic acids showed the lowest IC50 against alpha-glucosidase.	caffeic	44-51	sucrase-isomaltase	Homo sapiens	108-125
34862640-5	2022	Ki values of the secnidazole derivatives 1-30 for hCA I, hCA II, AChE, BChE, and alpha-glucosidase enzymes were obtained in the ranges of 47.37-190.74, 44.38-198.21, 12.14-68.37, 8.04-61.53, and 7.78-45.91 nM, respectively.	secnidazole	17-28	sucrase-isomaltase	Homo sapiens	81-98
34638063-0	2022	The inhibitory mechanism of chlorogenic acid and its acylated derivatives on alpha-amylase and alpha-glucosidase.	Chlorogenic Acid	28-44	sucrase-isomaltase	Homo sapiens	95-112
34638063-3	2022	Results showed that the inhibitory activities of CA derivatives on alpha-amylase and alpha-glucosidase were enhanced as lipophilicity increased, and the inhibitory activities of C12-CA were stronger than those of CA.	c12-ca	178-184	sucrase-isomaltase	Homo sapiens	85-102
34638063-4	2022	IC50 values of C12-CA were 13.30 +- 0.26 mumol/mL for alpha-amylase and 3.42 +- 0.10 mumol/mL for alpha-glucosidase.	c12-ca	15-21	sucrase-isomaltase	Homo sapiens	98-115
34638063-5	2022	C12-CA possessed the smallest Kic and Kiu values, and its inhibitory actions on alpha-amylase and alpha-glucosidase were stronger than those of CA and the other derivatives.	c12-ca	0-6	sucrase-isomaltase	Homo sapiens	98-115
34638063-6	2022	Effects of C12-CA on microenvironments of amino acid residues and secondary structures of alpha-amylase and alpha-glucosidase were greater than those of CA and the other derivatives.	c12-ca	11-17	sucrase-isomaltase	Homo sapiens	108-125
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	Flavonoids	28-38	sucrase-isomaltase	Homo sapiens	84-101
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	astilbin	119-127	sucrase-isomaltase	Homo sapiens	84-101
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	naringenin	186-196	sucrase-isomaltase	Homo sapiens	84-101
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	Acarbose	283-291	sucrase-isomaltase	Homo sapiens	84-101
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	38-48	sucrase-isomaltase	Homo sapiens	293-310
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	38-48	sucrase-isomaltase	Homo sapiens	386-403
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	169-179	sucrase-isomaltase	Homo sapiens	386-403
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Omeprazole	85-95	sucrase-isomaltase	Homo sapiens	177-194
34896919-5	2022	Conjugate 2a-1 having a six-carbon-atom linker fused to EGC and caffeic acid demonstrates the most ponent inhibitory activity to HPA and its selectivity towards HPA over alpha-glucosidase by far superior to that construct 1.	caffeic acid	64-76	sucrase-isomaltase	Homo sapiens	170-187
34896920-0	2022	Synthesis of new clioquinol derivatives as potent alpha-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies.	Clioquinol	17-27	sucrase-isomaltase	Homo sapiens	50-67
34802943-0	2022	Omeprazole inhibits alpha-glucosidase activity and the formation of nonenzymatic glycation products: Activity and mechanism.	Omeprazole	0-10	sucrase-isomaltase	Homo sapiens	20-37
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Omeprazole	166-176	sucrase-isomaltase	Homo sapiens	134-151
34802943-1	2022	In this study, the inhibitory effect and mechanism of omeprazole on alpha-glucosidase and nonenzymatic glycation were investigated in vitro by using multi-spectroscopic methods and molecular docking.	Omeprazole	54-64	sucrase-isomaltase	Homo sapiens	68-85
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Omeprazole	166-176	sucrase-isomaltase	Homo sapiens	177-194
34802943-2	2022	Enzyme kinetic results showed that omeprazole inhibited alpha-glucosidase in a reversible and noncompetitive manner (IC50= 0.595 +- 0.003 mM).	Omeprazole	35-45	sucrase-isomaltase	Homo sapiens	56-73
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Omeprazole	85-95	sucrase-isomaltase	Homo sapiens	134-151
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Hydrogen	223-231	sucrase-isomaltase	Homo sapiens	134-151
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Hydrogen	223-231	sucrase-isomaltase	Homo sapiens	177-194
34802943-4	2022	Molecular docking further confirmed that hydrogen bonds and hydrophobic forces were the major driving forces for omeprazole binding to alpha-glucosidase.	Hydrogen	41-49	sucrase-isomaltase	Homo sapiens	135-152
34802943-4	2022	Molecular docking further confirmed that hydrogen bonds and hydrophobic forces were the major driving forces for omeprazole binding to alpha-glucosidase.	Omeprazole	113-123	sucrase-isomaltase	Homo sapiens	135-152
34960905-9	2021	Ta-AgNPs potentials were confirmed by in vitro antidiabetic activity to constrain carbohydrate digesting enzymes, mainly alpha-amylase and alpha-glucosidase, with a definite concentration of sample displaying 50% inhibition (IC50), which is about 43.94 and 48.5 mug/mL, respectively.	Carbohydrates	82-94	sucrase-isomaltase	Homo sapiens	139-156
34801925-0	2022	Identification of raloxifene as a novel alpha-glucosidase inhibitor using a systematic drug repurposing approach in combination with cross molecular docking-based virtual screening and experimental verification.	Raloxifene Hydrochloride	18-28	sucrase-isomaltase	Homo sapiens	40-57
34801925-6	2022	Subsequently, an in vitro activity assay showed that raloxifene was an excellent inhibitor of alpha-glucosidase.	Raloxifene Hydrochloride	53-63	sucrase-isomaltase	Homo sapiens	94-111
34801925-10	2022	The molecular mechanisms agree well with its activity, reinforcing that raloxifene is a candidate alpha-glucosidase inhibitor.	Raloxifene Hydrochloride	72-82	sucrase-isomaltase	Homo sapiens	98-115
34822830-0	2022	Physicochemical properties, antioxidant activities and alpha-glucosidase inhibitory effects of polysaccharides from Evodiae fructus extracted by different solvents.	Polysaccharides	95-110	sucrase-isomaltase	Homo sapiens	55-72
34822830-8	2022	Therefore, polysaccharides extracted by water and alkaline solvents from Evodiae fructus could be developed as promising natural antioxidants and alpha-glucosidase inhibitors in the food and medicine industries.	Polysaccharides	11-26	sucrase-isomaltase	Homo sapiens	146-163
34822830-8	2022	Therefore, polysaccharides extracted by water and alkaline solvents from Evodiae fructus could be developed as promising natural antioxidants and alpha-glucosidase inhibitors in the food and medicine industries.	Water	40-45	sucrase-isomaltase	Homo sapiens	146-163
34914113-5	2022	Results of this study showed the improved alpha-glucosidase inhibitory activity of the quinoa bioactive peptides after germination and gastrointestinal digestion and highlighted the potential of metagenome-derived PersiAlpha-GL1 as a novel homologue of the human alpha-glucosidase for developing the future anti-diabetic drugs.	persialpha-gl1	214-228	sucrase-isomaltase	Homo sapiens	42-59
34914113-5	2022	Results of this study showed the improved alpha-glucosidase inhibitory activity of the quinoa bioactive peptides after germination and gastrointestinal digestion and highlighted the potential of metagenome-derived PersiAlpha-GL1 as a novel homologue of the human alpha-glucosidase for developing the future anti-diabetic drugs.	persialpha-gl1	214-228	sucrase-isomaltase	Homo sapiens	263-280
34399273-0	2022	Number of galloyl moiety and intramolecular bonds in galloyl-based polyphenols affect their interaction with alpha-glucosidase.	Polyphenols	67-78	sucrase-isomaltase	Homo sapiens	109-126
34399273-1	2022	The inhibition of alpha-glucosidase by nine galloyl-based polyphenols with free and unfree galloyl moieties (GMs) was studied.	galloyl-based polyphenols	44-69	sucrase-isomaltase	Homo sapiens	18-35
34399273-4	2022	Free GMs could bind not only with the active site of alpha-glucosidase (competitive inhibition character), but also with the non-active sites (uncompetitive one); however, the former binding interaction was stronger than the latter one.	gms	5-8	sucrase-isomaltase	Homo sapiens	53-70
34399273-5	2022	All polyphenols that had inhibitory effects quenched alpha-glucosidase fluorescence in a static mode through forming a polyphenol-enzyme complex.	Polyphenols	4-15	sucrase-isomaltase	Homo sapiens	53-70
34399273-5	2022	All polyphenols that had inhibitory effects quenched alpha-glucosidase fluorescence in a static mode through forming a polyphenol-enzyme complex.	Polyphenols	119-129	sucrase-isomaltase	Homo sapiens	53-70
34874169-6	2021	Molecular docking and amino acid composition analysis results showed that the high content of C-terminal Arg residues in the peptides could be the essential reason for their alpha-glucosidase inhibition activity.	Arginine	105-108	sucrase-isomaltase	Homo sapiens	174-191
34898206-0	2021	Insights into an alpha-Glucosidase Inhibitory Profile of 4,4-Dimethylsterols by Multispectral Techniques and Molecular Docking.	4,4-dimethylsterols	57-76	sucrase-isomaltase	Homo sapiens	17-34
34898206-2	2021	However, the potential mechanism by which 4,4-dimethylsterols inhibit alpha-glucosidase has not been elucidated.	4,4-dimethylsterols	42-61	sucrase-isomaltase	Homo sapiens	70-87
34898206-3	2021	In this work, the inhibitory activity and mechanism of 4,4-dimethylsterols against alpha-glucosidase were studied through kinetic analysis, fluorescence spectroscopy, ultraviolet spectroscopy, circular dichroism, and molecular docking.	4,4-dimethylsterols	55-74	sucrase-isomaltase	Homo sapiens	83-100
34898206-4	2021	4,4-Dimethylsterols showed higher inhibition activity against alpha-glucosidase than acarbose with an IC50 value of 0.71 mg/mL and a noncompetitive inhibition type.	4,4-dimethylsterols	0-19	sucrase-isomaltase	Homo sapiens	62-79
34898206-4	2021	4,4-Dimethylsterols showed higher inhibition activity against alpha-glucosidase than acarbose with an IC50 value of 0.71 mg/mL and a noncompetitive inhibition type.	Acarbose	85-93	sucrase-isomaltase	Homo sapiens	62-79
34898206-5	2021	They could bind to alpha-glucosidase through van der Waals forces and hydrogen bonds and quench its endofluorescence with a static quenching mechanism.	Hydrogen	70-78	sucrase-isomaltase	Homo sapiens	19-36
34898206-6	2021	Changes in the secondary structure of alpha-glucosidase were induced by its binding interaction with 4,4-dimethylsterols.	4,4-dimethylsterols	101-120	sucrase-isomaltase	Homo sapiens	38-55
34898206-7	2021	Molecular docking further indicated that a hydrogen bond was generated between OH at the C-3 position of 4,4-dimethylsterols and the alpha-glucosidase residue Arg-442.	Hydrogen	43-51	sucrase-isomaltase	Homo sapiens	133-150
34898206-7	2021	Molecular docking further indicated that a hydrogen bond was generated between OH at the C-3 position of 4,4-dimethylsterols and the alpha-glucosidase residue Arg-442.	4,4-dimethylsterols	105-124	sucrase-isomaltase	Homo sapiens	133-150
34898206-7	2021	Molecular docking further indicated that a hydrogen bond was generated between OH at the C-3 position of 4,4-dimethylsterols and the alpha-glucosidase residue Arg-442.	Arginine	159-162	sucrase-isomaltase	Homo sapiens	133-150
34109975-8	2021	Complexation increased the alpha-glucosidase and glycation inhibitory activity of vanillic acid by 3- and 2.6-folds, respectively.	Vanillic Acid	82-95	sucrase-isomaltase	Homo sapiens	27-44
34944521-0	2021	In Silico Approaches to Identify Polyphenol Compounds as alpha-Glucosidase and alpha-Amylase Inhibitors against Type-II Diabetes.	Polyphenols	33-43	sucrase-isomaltase	Homo sapiens	57-74
34944521-2	2021	Clinically, both alpha-glucosidase and alpha-amylase enzymes inhibitors can suppress peaks of postprandial glucose with surplus adverse effects, leading to efforts devoted to urgently seeking new anti-diabetes drugs from natural sources for delayed starch digestion.	Glucose	107-114	sucrase-isomaltase	Homo sapiens	17-34
34944521-2	2021	Clinically, both alpha-glucosidase and alpha-amylase enzymes inhibitors can suppress peaks of postprandial glucose with surplus adverse effects, leading to efforts devoted to urgently seeking new anti-diabetes drugs from natural sources for delayed starch digestion.	Starch	249-255	sucrase-isomaltase	Homo sapiens	17-34
34717239-0	2021	Discovery of new 2-phenyl-1H-benzo(d)imidazole core-based potent alpha-glucosidase inhibitors: Synthesis, kinetic study, molecular docking, and in vivo anti-hyperglycemic evaluation.	2-phenylbenzimidazole	17-46	sucrase-isomaltase	Homo sapiens	65-82
34175761-0	2021	Concentration effects on optical properties, DFT, crystal characterization and alpha-glucosidase activity studies: Novel Zn(II) complex.	zn(ii)	121-127	sucrase-isomaltase	Homo sapiens	79-96
34175761-4	2021	The IC50 value of Zn(II) complex against alpha-glucosidase was also obtained at 0.44 mM.	zn(ii)	18-24	sucrase-isomaltase	Homo sapiens	41-58
34717239-1	2021	In the present study, a series of 2-phenyl-1H-benzo(d)imidazole-based alpha-glucosidase inhibitors were synthesized and evaluated for their in vitro and in vivo anti-diabetic potential.	2-phenylbenzimidazole	34-63	sucrase-isomaltase	Homo sapiens	70-87
34717239-2	2021	Screening of an in-house library revealed a moderated alpha-glucosidase inhibitor, 6a with 3-(1H-benzo(d)imidazol-2-yl)aniline core, and then the structural optimization was performed to obtain more efficient derivatives.	3-(1h-benzo(d)imidazol-2-yl)aniline	91-126	sucrase-isomaltase	Homo sapiens	54-71
34736132-2	2021	Chlorogenic acid (1) has been shown to delay intestinal glucose absorption by inhibiting the activity of alpha-glucosidase (alpha-Glu) and alpha-amylase (alpha-Amy).	Chlorogenic Acid	0-16	sucrase-isomaltase	Homo sapiens	105-122
34736132-2	2021	Chlorogenic acid (1) has been shown to delay intestinal glucose absorption by inhibiting the activity of alpha-glucosidase (alpha-Glu) and alpha-amylase (alpha-Amy).	Glucose	56-63	sucrase-isomaltase	Homo sapiens	105-122
34736132-2	2021	Chlorogenic acid (1) has been shown to delay intestinal glucose absorption by inhibiting the activity of alpha-glucosidase (alpha-Glu) and alpha-amylase (alpha-Amy).	Glutamic Acid	130-133	sucrase-isomaltase	Homo sapiens	105-122
34762397-0	2021	alpha-Glucosidase-Triggered Reaction for Fluorometric and Colorimetric Assays Based on the Formation of Silicon-Containing Nanoparticles.	Silicon	104-111	sucrase-isomaltase	Homo sapiens	0-17
34843085-5	2021	Hypoglycemic activity of Se-polysaccharides is closely related to their inhibitory effect on alpha-amylase and alpha-glucosidase, influence on insulin signal pathway especially IRS-PI3K-Akt signaling pathway, and protection capacity against oxidative stress.	se-polysaccharides	25-43	sucrase-isomaltase	Homo sapiens	111-128
34459690-0	2021	In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential alpha-glucosidase and alpha-amylase inhibitors.	bis (indol-3-yl) methane	34-58	sucrase-isomaltase	Homo sapiens	84-101
34459690-1	2021	In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against alpha-glucosidase and alpha-amylase.	bis (indol-3-yl) methanes	15-40	sucrase-isomaltase	Homo sapiens	117-134
34459690-1	2021	In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against alpha-glucosidase and alpha-amylase.	bims	42-46	sucrase-isomaltase	Homo sapiens	117-134
34459690-3	2021	Compounds 5 g (IC50: 7.54 +- 1.10 muM), 5e (IC50: 9.00 +- 0.97 muM), and 5 h (IC50: 9.57 +- 0.62 muM) presented strongest inhibitory activities against alpha-glucosidase, that were ~ 30 times stronger than acarbose.	Acarbose	206-214	sucrase-isomaltase	Homo sapiens	152-169
34459690-7	2021	Furthermore, compounds showed no toxicity against 3T3-L1 cells and HepG2 cells.HighlightsA series of bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated inhibitory activities against alpha-glucosidase and alpha-amylase.Compound 5g exhibited promising activity (IC50 = 7.54 +- 1.10 muM) against alpha-glucosidase.Compound 5s exhibited promising activity (IC50 = 30.91 +- 0.86 muM) against alpha-amylase.In silico studies were performed to confirm the binding interactions of synthetic compounds with the enzyme active site.	bis (indol-3-yl) methanes	101-126	sucrase-isomaltase	Homo sapiens	195-212
34459690-7	2021	Furthermore, compounds showed no toxicity against 3T3-L1 cells and HepG2 cells.HighlightsA series of bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated inhibitory activities against alpha-glucosidase and alpha-amylase.Compound 5g exhibited promising activity (IC50 = 7.54 +- 1.10 muM) against alpha-glucosidase.Compound 5s exhibited promising activity (IC50 = 30.91 +- 0.86 muM) against alpha-amylase.In silico studies were performed to confirm the binding interactions of synthetic compounds with the enzyme active site.	bis (indol-3-yl) methanes	101-126	sucrase-isomaltase	Homo sapiens	306-323
34885862-9	2021	Further bioactivity evaluation showed that R- and S-EGCG-cThea possessed in vitro inhibition effects on alpha-glucosidase with IC50 of 70.3 and 161.7 muM, respectively.	r- and s-egcg-cthea	43-62	sucrase-isomaltase	Homo sapiens	104-121
34762397-3	2021	Inspired by the HQ-regulated facile synthetic step and the generation of HQ from alpha-glucosidase (alpha-Glu)-catalyzed hydrolysis of 4-hydroxyphenyl-alpha-d-glucopyranosyl (4-HPalphaDG), we have designed a straightforward colorimetric and fluorometric alpha-Glu activity assay using a commercially available 4-HPalphaDG as the alpha-Glu substrate.	4-hydroxyphenyl-alpha-d-glucopyranosyl	135-173	sucrase-isomaltase	Homo sapiens	81-98
34762397-3	2021	Inspired by the HQ-regulated facile synthetic step and the generation of HQ from alpha-glucosidase (alpha-Glu)-catalyzed hydrolysis of 4-hydroxyphenyl-alpha-d-glucopyranosyl (4-HPalphaDG), we have designed a straightforward colorimetric and fluorometric alpha-Glu activity assay using a commercially available 4-HPalphaDG as the alpha-Glu substrate.	4-hpalphadg	175-186	sucrase-isomaltase	Homo sapiens	81-98
34762397-3	2021	Inspired by the HQ-regulated facile synthetic step and the generation of HQ from alpha-glucosidase (alpha-Glu)-catalyzed hydrolysis of 4-hydroxyphenyl-alpha-d-glucopyranosyl (4-HPalphaDG), we have designed a straightforward colorimetric and fluorometric alpha-Glu activity assay using a commercially available 4-HPalphaDG as the alpha-Glu substrate.	4-hpalphadg	310-321	sucrase-isomaltase	Homo sapiens	81-98
34833966-7	2021	Extracts of the maize hybrids scavenged DPPH  (SC50: 9.07-26.35 mg/mL) and ABTS + (2.65-7.68 TEAC mmol/g), reduced Fe3+ to Fe2+ (0.25 +- 0.64-0.43 +- 0.01 mg GAE/g), and inhibited alpha-amylase and alpha-glucosidase, with IC50 ranges of 26.28-52.55 mg/mL and 47.72-63.98 mg/mL, respectively.	1,1-diphenyl-2-picrylhydrazyl	40-44	sucrase-isomaltase	Homo sapiens	198-215
34438122-0	2021	Novel cinnamic acid magnolol derivatives as potent alpha-glucosidase and alpha-amylase inhibitors: Synthesis, in vitro and in silico studies.	cinnamic acid	6-19	sucrase-isomaltase	Homo sapiens	51-68
34606154-6	2021	Antioxidants (N-acetylcysteine, idebenone, resveratrol, edaravone) improved alpha-glucosidase activity in rhGAA-treated cells, enhanced enzyme processing, and improved mannose-6-phosphate receptor localization.	Acetylcysteine	14-30	sucrase-isomaltase	Homo sapiens	76-93
34606154-6	2021	Antioxidants (N-acetylcysteine, idebenone, resveratrol, edaravone) improved alpha-glucosidase activity in rhGAA-treated cells, enhanced enzyme processing, and improved mannose-6-phosphate receptor localization.	idebenone	32-41	sucrase-isomaltase	Homo sapiens	76-93
34606154-6	2021	Antioxidants (N-acetylcysteine, idebenone, resveratrol, edaravone) improved alpha-glucosidase activity in rhGAA-treated cells, enhanced enzyme processing, and improved mannose-6-phosphate receptor localization.	Resveratrol	43-54	sucrase-isomaltase	Homo sapiens	76-93
34606154-6	2021	Antioxidants (N-acetylcysteine, idebenone, resveratrol, edaravone) improved alpha-glucosidase activity in rhGAA-treated cells, enhanced enzyme processing, and improved mannose-6-phosphate receptor localization.	Edaravone	56-65	sucrase-isomaltase	Homo sapiens	76-93
34771127-6	2021	Correlation analysis indicated that the main galloylated catechins and flavonoid glycosides were highly related to their antioxidant capacity and inhibitory effects on alpha-amylase and alpha-glucosidase.	Catechin	57-66	sucrase-isomaltase	Homo sapiens	186-203
34771127-6	2021	Correlation analysis indicated that the main galloylated catechins and flavonoid glycosides were highly related to their antioxidant capacity and inhibitory effects on alpha-amylase and alpha-glucosidase.	Flavonoids	71-80	sucrase-isomaltase	Homo sapiens	186-203
34771127-6	2021	Correlation analysis indicated that the main galloylated catechins and flavonoid glycosides were highly related to their antioxidant capacity and inhibitory effects on alpha-amylase and alpha-glucosidase.	Glycosides	81-91	sucrase-isomaltase	Homo sapiens	186-203
34237621-4	2021	Thiolane-based bioactive organic compounds have manifested a plethora of astonishing biological activities such as anti-viral, anti-cancer, anti-platelet, alpha-glucosidase inhibition, anti-HIV, immunosuppressive and anti-microbial activities which renders them excellent candidates in drug discovery.	tetrahydrothiophene	0-8	sucrase-isomaltase	Homo sapiens	155-172
34438122-0	2021	Novel cinnamic acid magnolol derivatives as potent alpha-glucosidase and alpha-amylase inhibitors: Synthesis, in vitro and in silico studies.	magnolol	20-28	sucrase-isomaltase	Homo sapiens	51-68
34481854-0	2021	Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of alpha-glucosidase and alpha-amylase along with their in-silico study.	indole	13-19	sucrase-isomaltase	Homo sapiens	91-108
34600331-0	2021	Isatin-hydrazide conjugates as potent alpha-amylase and alpha-glucosidase inhibitors: Synthesis, structure and invitro evaluations.	isatin-hydrazide	0-16	sucrase-isomaltase	Homo sapiens	56-73
34600331-2	2021	The inhibition of alpha-amylase and alpha-glucosidase enzymes which are responsible for the digestion of dietary carbohydrates is an effective strategy to control postprandial hyperglycemia.	Carbohydrates	113-126	sucrase-isomaltase	Homo sapiens	36-53
34600331-3	2021	Herein, we report the novel and highly potent inhibitors of alpha-amylase and alpha-glucosidase, namely isatin-hydrazide conjugates 1a - 1j that are easily accessed in two steps from simple and inexpensive commercially available isatin.	isatin-hydrazide	104-120	sucrase-isomaltase	Homo sapiens	78-95
34600331-3	2021	Herein, we report the novel and highly potent inhibitors of alpha-amylase and alpha-glucosidase, namely isatin-hydrazide conjugates 1a - 1j that are easily accessed in two steps from simple and inexpensive commercially available isatin.	Isatin	229-235	sucrase-isomaltase	Homo sapiens	78-95
34490702-1	2021	AIMS: To investigate the association between the use of alpha-glucosidase inhibitors (AGIs) and the risk of psoriatic disease (i.e., psoriasis and psoriatic arthritis) in patients with type 2 diabetes mellitus (T2DM) treated with metformin.	Metformin	230-239	sucrase-isomaltase	Homo sapiens	56-73
34529335-0	2021	Cytotoxic and alpha-Glucosidase Inhibitory Xanthones from Garcinia mckeaniana Leaves and Molecular Docking Study.	Xanthones	43-52	sucrase-isomaltase	Homo sapiens	14-31
34529335-6	2021	Norathyriol ( 8 ) was a promising alpha-glucosidase inhibitor, with an IC 50  value of 0.07 muM, much higher than that of the positive control, acarbose (IC 50  161.0 muM).	norathyriol	0-11	sucrase-isomaltase	Homo sapiens	34-51
34529335-6	2021	Norathyriol ( 8 ) was a promising alpha-glucosidase inhibitor, with an IC 50  value of 0.07 muM, much higher than that of the positive control, acarbose (IC 50  161.0 muM).	Acarbose	144-152	sucrase-isomaltase	Homo sapiens	34-51
34117784-8	2021	Nevertheless, the transition metal complexes of anthranilic acid derivatives offer therapeutic applications in diabetes mellitus, and obesity by regulating the activity of alpha-glucosidase.	Metals	29-34	sucrase-isomaltase	Homo sapiens	172-189
34117784-8	2021	Nevertheless, the transition metal complexes of anthranilic acid derivatives offer therapeutic applications in diabetes mellitus, and obesity by regulating the activity of alpha-glucosidase.	anthranilic acid	48-64	sucrase-isomaltase	Homo sapiens	172-189
34834714-10	2021	Molecular docking showed that verbascoside and kaempferol displayed the highest fitting within human alpha-amylase (HA) and human alpha-glucosidase (HG) active sites, respectively.	acteoside	30-42	sucrase-isomaltase	Homo sapiens	130-147
34771042-9	2021	The maximum inhibition by nanosponges against alpha-glucosidase was observed to be 0.9352 +- 0.0856 microM, 3.11-fold higher than acarbose.	Acarbose	130-138	sucrase-isomaltase	Homo sapiens	46-63
34834714-10	2021	Molecular docking showed that verbascoside and kaempferol displayed the highest fitting within human alpha-amylase (HA) and human alpha-glucosidase (HG) active sites, respectively.	kaempferol	47-57	sucrase-isomaltase	Homo sapiens	130-147
34829542-1	2021	Cyanidin-3-O-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and alpha-glucosidase inhibition effects.	Anthocyanins	45-56	sucrase-isomaltase	Homo sapiens	149-166
34697701-0	2021	One-pot multi-component synthesis of novel chromeno(4,3-b)pyrrol-3-yl derivatives as alpha-glucosidase inhibitors.	chromeno(4,3-b)pyrrol-3-yl derivatives	43-81	sucrase-isomaltase	Homo sapiens	85-102
34697701-6	2021	Moreover, docking studies revealed that dihydrochromeno(4,3-b)pyrrol-3-yl effectively interacted with important residues in the active site of alpha-glucosidase.	dihydrochromeno(4,3-b)pyrrol-3-yl	40-73	sucrase-isomaltase	Homo sapiens	143-160
34662924-0	2021	Critical Assessment of In Vitro Screening of alpha-Glucosidase Inhibitors from Plants with Acarbose as a Reference Standard.	Acarbose	91-99	sucrase-isomaltase	Homo sapiens	45-62
34675367-0	2021	Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new alpha-glucosidase inhibitor.	pyrazole	76-84	sucrase-isomaltase	Homo sapiens	111-128
34675367-0	2021	Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new alpha-glucosidase inhibitor.	benzofuran	85-95	sucrase-isomaltase	Homo sapiens	111-128
34675367-1	2021	In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against alpha-glucosidase activity.	biphenyl pyrazole	33-50	sucrase-isomaltase	Homo sapiens	174-191
34675367-1	2021	In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against alpha-glucosidase activity.	benzofuran	51-61	sucrase-isomaltase	Homo sapiens	174-191
34662924-2	2021	Side effects of acarbose motivated a growing number of screening studies to identify novel alpha-glucosidase inhibitors derived from plant extracts and other natural sources.	Acarbose	16-24	sucrase-isomaltase	Homo sapiens	91-108
34692755-0	2021	Both Acidic pH Value and Binding Interactions of Tartaric Acid With alpha-Glucosidase Cause the Enzyme Inhibition: The Mechanism in alpha-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates.	tartaric acid	49-62	sucrase-isomaltase	Homo sapiens	68-85
34760039-7	2021	SI and CD10 were expressed on the luminal surfaces of the columnar cells.	Phenobarbital	34-41	sucrase-isomaltase	Homo sapiens	0-2
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	tartaric acid	45-58	sucrase-isomaltase	Homo sapiens	171-188
34418573-0	2021	Synthesis and biological evaluation of 1,6-bis-triazole-2,3,4-tri-O-benzyl-alpha-D-glucopyranosides as a novel alpha-glucosidase inhibitor in the treatment of Type 2 diabetes.	1,6-bis-triazole-2,3,4-tri-o-benzyl-alpha-d-glucopyranosides	39-99	sucrase-isomaltase	Homo sapiens	111-128
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	caffeic acid	80-92	sucrase-isomaltase	Homo sapiens	171-188
34692755-0	2021	Both Acidic pH Value and Binding Interactions of Tartaric Acid With alpha-Glucosidase Cause the Enzyme Inhibition: The Mechanism in alpha-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates.	tartaric acid	49-62	sucrase-isomaltase	Homo sapiens	132-149
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	tartaric acid	99-112	sucrase-isomaltase	Homo sapiens	171-188
34692755-0	2021	Both Acidic pH Value and Binding Interactions of Tartaric Acid With alpha-Glucosidase Cause the Enzyme Inhibition: The Mechanism in alpha-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates.	caffeic	169-176	sucrase-isomaltase	Homo sapiens	68-85
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	tartaric acid	114-116	sucrase-isomaltase	Homo sapiens	171-188
34692755-0	2021	Both Acidic pH Value and Binding Interactions of Tartaric Acid With alpha-Glucosidase Cause the Enzyme Inhibition: The Mechanism in alpha-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates.	caffeic	169-176	sucrase-isomaltase	Homo sapiens	132-149
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	caftaric acid	119-132	sucrase-isomaltase	Homo sapiens	171-188
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	caftaric acid	134-137	sucrase-isomaltase	Homo sapiens	171-188
34692755-0	2021	Both Acidic pH Value and Binding Interactions of Tartaric Acid With alpha-Glucosidase Cause the Enzyme Inhibition: The Mechanism in alpha-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates.	tartaric acid	181-194	sucrase-isomaltase	Homo sapiens	68-85
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	chicoric acid	143-156	sucrase-isomaltase	Homo sapiens	171-188
34692755-0	2021	Both Acidic pH Value and Binding Interactions of Tartaric Acid With alpha-Glucosidase Cause the Enzyme Inhibition: The Mechanism in alpha-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates.	tartaric acid	181-194	sucrase-isomaltase	Homo sapiens	132-149
34692755-4	2021	Besides, CA, CFA and CHA were shown with strong quenching effects on alpha-glucosidase fluorescence because of pi-conjugations between aromatic ring of caffeoyl moiety and that of enzyme fluorescent residues.	caftaric acid	13-16	sucrase-isomaltase	Homo sapiens	69-86
34692755-1	2021	The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against alpha-glucosidase was characterized by substrate depletion, fluorescence quenching, isothermal titration calorimetry (ITC) and molecular docking.	caffeic	33-40	sucrase-isomaltase	Homo sapiens	171-188
34692755-4	2021	Besides, CA, CFA and CHA were shown with strong quenching effects on alpha-glucosidase fluorescence because of pi-conjugations between aromatic ring of caffeoyl moiety and that of enzyme fluorescent residues.	caffeoyl	152-160	sucrase-isomaltase	Homo sapiens	69-86
34692755-6	2021	Additionally, a direct binding interaction behavior was observed for TA with alpha-glucosidase according to the fitted independent binding model in ITC, but not for CFA and CHA.	tartaric acid	69-71	sucrase-isomaltase	Homo sapiens	77-94
34692755-7	2021	Therefore, both acidic pH and binding interactions of TA with alpha-glucosidase resulted in the enzyme inhibition.	tartaric acid	54-56	sucrase-isomaltase	Homo sapiens	62-79
34388484-0	2021	Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against alpha-Glucosidase.	myricetin	22-32	sucrase-isomaltase	Homo sapiens	103-120
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	myricetin	57-67	sucrase-isomaltase	Homo sapiens	0-17
34388484-0	2021	Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against alpha-Glucosidase.	Quercetin	34-44	sucrase-isomaltase	Homo sapiens	103-120
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	Quercetin	69-79	sucrase-isomaltase	Homo sapiens	0-17
34388484-0	2021	Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against alpha-Glucosidase.	Catechin	49-58	sucrase-isomaltase	Homo sapiens	103-120
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	Catechin	84-93	sucrase-isomaltase	Homo sapiens	0-17
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	Flavonoids	35-45	sucrase-isomaltase	Homo sapiens	0-17
34388484-2	2021	It was found that C4 = O, C2 = C3, 3-OH and 5"-OH were essential moieties for alpha-glucosidase inhibition of myricetin that was shown with the highest inhibitory activity.	myricetin	110-119	sucrase-isomaltase	Homo sapiens	78-95
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	18-27	sucrase-isomaltase	Homo sapiens	96-113
34411978-0	2021	Novel tetrahydrobenzo(b)thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation.	Urea	38-42	sucrase-isomaltase	Homo sapiens	64-81
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	18-27	sucrase-isomaltase	Homo sapiens	287-304
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	82-92	sucrase-isomaltase	Homo sapiens	96-113
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	82-92	sucrase-isomaltase	Homo sapiens	287-304
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	323-333	sucrase-isomaltase	Homo sapiens	96-113
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	323-333	sucrase-isomaltase	Homo sapiens	287-304
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	453-462	sucrase-isomaltase	Homo sapiens	96-113
34411978-1	2021	alpha-Glucosidase inhibitors, which can inhibit the digestion of carbohydrates into glucose, are one of important groups of anti-type 2 diabetic drugs.	Carbohydrates	65-78	sucrase-isomaltase	Homo sapiens	0-17
34411978-1	2021	alpha-Glucosidase inhibitors, which can inhibit the digestion of carbohydrates into glucose, are one of important groups of anti-type 2 diabetic drugs.	Glucose	84-91	sucrase-isomaltase	Homo sapiens	0-17
34411978-2	2021	In the present study, we report our effort on the discovery and optimization of alpha-glucosidase inhibitors with tetrahydrobenzo(b)thiophen-2-yl)urea core.	Urea	146-150	sucrase-isomaltase	Homo sapiens	80-97
34411978-10	2021	The present study provided the tetrahydrobenzo(b)thiophen-2-yl)urea chemotype for developing novel alpha-glucosidase inhibitors against type 2 diabetes.	Urea	63-67	sucrase-isomaltase	Homo sapiens	99-116
34591286-1	2021	Avalglucosidase alfa (NEXVIAZYME ; avalglucosidase alfa-ngpt) is a hydrolytic lysosomal glycogen-specific recombinant human alpha-glucosidase product being developed by Sanofi Genzyme (formerly Genzyme Corporation) for the treatment of Pompe disease.	Glycogen	88-96	sucrase-isomaltase	Homo sapiens	124-141
34333423-0	2021	Pentacyclic triterpene carboxylic acids derivatives integrated piperazine-amino acid complexes for alpha-glucosidase inhibition in vitro.	pentacyclic	0-11	sucrase-isomaltase	Homo sapiens	99-116
34333423-0	2021	Pentacyclic triterpene carboxylic acids derivatives integrated piperazine-amino acid complexes for alpha-glucosidase inhibition in vitro.	triterpene carboxylic acids	12-39	sucrase-isomaltase	Homo sapiens	99-116
34333423-0	2021	Pentacyclic triterpene carboxylic acids derivatives integrated piperazine-amino acid complexes for alpha-glucosidase inhibition in vitro.	Piperazine	63-73	sucrase-isomaltase	Homo sapiens	99-116
34333423-5	2021	The comparison of two different solvent systems showed that the derivatives had better alpha-glucosidase inhibitory activity in the DMSO system than that of in ethanol-water system.	Dimethyl Sulfoxide	132-136	sucrase-isomaltase	Homo sapiens	87-104
34333423-5	2021	The comparison of two different solvent systems showed that the derivatives had better alpha-glucosidase inhibitory activity in the DMSO system than that of in ethanol-water system.	Ethanol	160-167	sucrase-isomaltase	Homo sapiens	87-104
34333423-5	2021	The comparison of two different solvent systems showed that the derivatives had better alpha-glucosidase inhibitory activity in the DMSO system than that of in ethanol-water system.	Water	168-173	sucrase-isomaltase	Homo sapiens	87-104
34333423-6	2021	Regrettably, all of the as-synthesized derivatives exhibited inferior alpha-glucosidase inhibitory activities than those of the parent compounds in both test solvent systems.	Arsenic	24-26	sucrase-isomaltase	Homo sapiens	70-87
34463509-0	2021	Inhibition Mechanism of alpha-Amylase/alpha-Glucosidase by Silibinin, Its Synergism with Acarbose, and the Effect of Milk Proteins.	Silybin	59-68	sucrase-isomaltase	Homo sapiens	38-55
34535900-0	2021	Inhibitory properties of polyphenols in Malus "Winter Red" crabapple fruit on alpha-glucosidase and alpha-amylase using improved methods.	Polyphenols	25-36	sucrase-isomaltase	Homo sapiens	78-95
34535900-1	2021	To explore the inhibitory activity of polyphenols on alpha-glucosidase and alpha-amylase, 16 polyphenols were isolated, identified, and quantified in an edible Malus "Winter Red" crabapple fruit.	Polyphenols	38-49	sucrase-isomaltase	Homo sapiens	53-70
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	Acarbose	33-41	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	miglito	46-53	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	Polyphenols	60-71	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	scutellarein	93-102	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	cyanidin	104-112	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	Quercetin	114-123	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	Phloretin	125-134	sucrase-isomaltase	Homo sapiens	194-211
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	3-hydroxyphloretin	140-158	sucrase-isomaltase	Homo sapiens	194-211
34632227-1	2021	alpha-Glucosyl triazoles have rarely been tested as alpha-glucosidase inhibitors, partly due to inefficient synthesis of their precursor alpha-d-glucosylazide (alphaGA1).	alpha-glucosyl triazoles	0-24	sucrase-isomaltase	Homo sapiens	52-69
34632227-1	2021	alpha-Glucosyl triazoles have rarely been tested as alpha-glucosidase inhibitors, partly due to inefficient synthesis of their precursor alpha-d-glucosylazide (alphaGA1).	alpha-d-glucosylazide	137-158	sucrase-isomaltase	Homo sapiens	52-69
34632227-1	2021	alpha-Glucosyl triazoles have rarely been tested as alpha-glucosidase inhibitors, partly due to inefficient synthesis of their precursor alpha-d-glucosylazide (alphaGA1).	alphaga1	160-168	sucrase-isomaltase	Homo sapiens	52-69
34632227-6	2021	Several of these glucosyl triazoles exhibited strong inhibition of human lysosomal alpha-glucosidase, with IC50 values for AGT4 and AGT14 more than 60-fold lower than that of the commercial alpha-glucosidase inhibitor acarbose.	glucosyl triazoles	17-35	sucrase-isomaltase	Homo sapiens	190-207
34632227-6	2021	Several of these glucosyl triazoles exhibited strong inhibition of human lysosomal alpha-glucosidase, with IC50 values for AGT4 and AGT14 more than 60-fold lower than that of the commercial alpha-glucosidase inhibitor acarbose.	Acarbose	218-226	sucrase-isomaltase	Homo sapiens	190-207
34463509-3	2021	The results indicated that silibinin showed a strong inhibitory efficiency against alpha-amylase/alpha-glucosidase in noncompetitive manners and exhibited synergistic inhibition against alpha-glucosidase with acarbose.	Silybin	27-36	sucrase-isomaltase	Homo sapiens	186-203
34463509-3	2021	The results indicated that silibinin showed a strong inhibitory efficiency against alpha-amylase/alpha-glucosidase in noncompetitive manners and exhibited synergistic inhibition against alpha-glucosidase with acarbose.	Acarbose	209-217	sucrase-isomaltase	Homo sapiens	186-203
34463509-5	2021	Furthermore, silibinin could combine with the inactive site of alpha-amylase/alpha-glucosidase and change the microenvironment and secondary structure of the enzymes, thereby influencing the catalytic efficiency of enzymes.	Silybin	13-22	sucrase-isomaltase	Homo sapiens	77-94
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	Quercetin	103-112	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	quercitrin	114-124	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	Luteolin	126-134	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	5-deoxyluteolin	136-151	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	4-methyl ether isoliquiritigenin	153-185	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	3,2",4"-trihydroxy-4-methoxychalcone	187-223	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	Stigmasterol	225-237	sucrase-isomaltase	Homo sapiens	4-21
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	gamma-sitosterol	242-257	sucrase-isomaltase	Homo sapiens	4-21
34463509-2	2021	Therefore, in this study, the inhibitory effect and underlying mechanism of silibinin against alpha-amylase/alpha-glucosidase were investigated.	Silybin	76-85	sucrase-isomaltase	Homo sapiens	108-125
34463509-3	2021	The results indicated that silibinin showed a strong inhibitory efficiency against alpha-amylase/alpha-glucosidase in noncompetitive manners and exhibited synergistic inhibition against alpha-glucosidase with acarbose.	Silybin	27-36	sucrase-isomaltase	Homo sapiens	97-114
34153810-0	2021	A facile approach synthesis of benzoylaryl benzimidazole as potential alpha-amylase and alpha-glucosidase inhibitor with antioxidant activity.	benzoylaryl benzimidazole	31-56	sucrase-isomaltase	Homo sapiens	88-105
34498967-4	2021	Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards alpha-glucosidase, and gamma-mangostin (5) exhibited the most remarkable effect with IC50 value of 15.3 +- 0.9 microM (compared with acarbose, IC50 = 224.9 +- 3.6 microM).	gamma-mangostin	104-119	sucrase-isomaltase	Homo sapiens	81-98
34498967-4	2021	Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards alpha-glucosidase, and gamma-mangostin (5) exhibited the most remarkable effect with IC50 value of 15.3 +- 0.9 microM (compared with acarbose, IC50 = 224.9 +- 3.6 microM).	Acarbose	214-222	sucrase-isomaltase	Homo sapiens	81-98
34232231-0	2021	Investigation into the mechanisms of quercetin-3-O-glucuronide inhibiting alpha-glucosidase activity and non-enzymatic glycation by spectroscopy and molecular docking.	Quercetin	37-46	sucrase-isomaltase	Homo sapiens	74-91
34232231-0	2021	Investigation into the mechanisms of quercetin-3-O-glucuronide inhibiting alpha-glucosidase activity and non-enzymatic glycation by spectroscopy and molecular docking.	3-o-glucuronide	47-62	sucrase-isomaltase	Homo sapiens	74-91
34232231-2	2021	In this study, quercetin-3-O-glucuronide (Q3GA) showed reversible and mixed-mode inhibition of alpha-glucosidase activity, with an IC50 value of 108.11 +- 4.61 muM.	quercetin 3-O-glucuronide	15-40	sucrase-isomaltase	Homo sapiens	95-112
34232231-3	2021	This was mainly due to the spontaneous formation of Q3GA-alpha-glucosidase driven by hydrogen bonding and van der Waals forces, which could change the microenvironments and conformation of alpha-glucosidase.	Hydrogen	85-93	sucrase-isomaltase	Homo sapiens	189-206
34153810-4	2021	The target benzimidazole 3f containing hydroxyl motif at para-position of phenyl revealed an important activity inhibitor against alpha- amylase (IC50 = 12.09 +- 0.38 microM) and alpha-glucosidase (IC50 = 11.02 +- 0.04 microM) comparable to the reference drug acarbose.	benzimidazole	11-24	sucrase-isomaltase	Homo sapiens	179-196
34246971-0	2021	Design and synthesis of novel quinazolinone-pyrazole derivatives as potential alpha-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study.	Quinazolinones	30-43	sucrase-isomaltase	Homo sapiens	78-95
34246971-0	2021	Design and synthesis of novel quinazolinone-pyrazole derivatives as potential alpha-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study.	pyrazole	44-52	sucrase-isomaltase	Homo sapiens	78-95
34540879-9	2021	A strong alpha-glucosidase-inhibiting activity (IC50, 156.25-291.11 mug/ml) was found in three DESs extracts.	Dioctyl Sulfosuccinic Acid	95-99	sucrase-isomaltase	Homo sapiens	9-26
34246971-1	2021	In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized and screened for their alpha-glucosidase inhibitory activity.	Quinazolinones	31-44	sucrase-isomaltase	Homo sapiens	112-129
34246971-1	2021	In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized and screened for their alpha-glucosidase inhibitory activity.	pyrazole	45-53	sucrase-isomaltase	Homo sapiens	112-129
34366474-2	2021	Total phenols (TP), flavonoids (TF), flavanols (TFLA), antioxidant and antidiabetic (alpha-glucosidase inhibition) activity were higher in Matcha tea before and in most in vitro digestion phases.	matcha tea	139-149	sucrase-isomaltase	Homo sapiens	85-102
34242650-0	2021	The glucose-regulated protein GRP94 interacts avidly in the endoplasmic reticulum with sucrase-isomaltase isoforms that are associated with congenital sucrase-isomaltase deficiency.	Glucose	4-11	sucrase-isomaltase	Homo sapiens	87-105
34527658-2	2021	alpha-Glucosidase inhibitors have been used to control postprandial glucose levels caused by type 2 diabetes since 1990. alpha-Glucosidases are rather crucial in the human metabolic system and are principally found in families 13 and 31.	Glucose	68-75	sucrase-isomaltase	Homo sapiens	0-17
34463216-1	2021	Herein, we report the synthesis and inhibitory potential of indazole (Methyl 1H-indazole-4-carboxylate) derivatives (1-13) against alpha-amylase and alpha-glucosidase enzymes.	Indazoles	60-68	sucrase-isomaltase	Homo sapiens	149-166
34463216-1	2021	Herein, we report the synthesis and inhibitory potential of indazole (Methyl 1H-indazole-4-carboxylate) derivatives (1-13) against alpha-amylase and alpha-glucosidase enzymes.	Methyl 1H-indazole-4-carboxylate	70-102	sucrase-isomaltase	Homo sapiens	149-166
34836859-0	2021	Synthesis and alpha-glucosidase inhibition studies of norfloxacin-acetanilide hybrids.	Norfloxacin	54-65	sucrase-isomaltase	Homo sapiens	14-31
34836859-0	2021	Synthesis and alpha-glucosidase inhibition studies of norfloxacin-acetanilide hybrids.	acetanilide	66-77	sucrase-isomaltase	Homo sapiens	14-31
34836859-2	2021	In this study, a series of new norfloxacin-acetanilide hybrid molecules were synthesized and screened for alpha-glucosidase inhibition activity.	norfloxacin-acetanilide	31-54	sucrase-isomaltase	Homo sapiens	106-123
34836865-0	2021	In-silico modeling and in-vitro studies of 2,1-benzothiazine-2,2-dioxide based hydrazone derivatives as alpha-glucosidase inhibitors.	2,1-benzothiazine-2,2-dioxide	43-72	sucrase-isomaltase	Homo sapiens	104-121
34836865-0	2021	In-silico modeling and in-vitro studies of 2,1-benzothiazine-2,2-dioxide based hydrazone derivatives as alpha-glucosidase inhibitors.	Hydrazones	79-88	sucrase-isomaltase	Homo sapiens	104-121
34836865-3	2021	This research article deals with the identification of benzothiazine derivatives as alpha-glucosidase inhibitors through in-silico techniques and then the confirmation through in-vitro analysis.	benzothiazine	55-68	sucrase-isomaltase	Homo sapiens	84-101
34443347-10	2021	In addition, compounds 10a, 10e, 10h, 10g, 10k, 10l, and 10m also exhibited pronounced potential for alpha-glucosidase inhibition with IC50 value ranging from 15 +- 0.037 to 32.27 +- 0.050 microM when compared with the reference drug acarbose (IC50 = 58.8 +- 0.12 muM).	Acarbose	234-242	sucrase-isomaltase	Homo sapiens	101-118
34384326-9	2021	The interpretation of developed models explains the role of different structural attributes in predicting the pIC50 of xanthone derivatives as alpha-glucosidase inhibitors.	xanthone	119-127	sucrase-isomaltase	Homo sapiens	143-160
34124938-15	2021	produce an alpha-glucosidase enzyme that may contribute to the multistep process of glycogen metabolism by releasing glucose from maltooligosaccharides.	Glycogen	84-92	sucrase-isomaltase	Homo sapiens	11-28
34124938-15	2021	produce an alpha-glucosidase enzyme that may contribute to the multistep process of glycogen metabolism by releasing glucose from maltooligosaccharides.	Glucose	117-124	sucrase-isomaltase	Homo sapiens	11-28
34124938-15	2021	produce an alpha-glucosidase enzyme that may contribute to the multistep process of glycogen metabolism by releasing glucose from maltooligosaccharides.	maltooligosaccharides	130-151	sucrase-isomaltase	Homo sapiens	11-28
34443347-0	2021	Discovery of Amide-Functionalized Benzimidazolium Salts as Potent alpha-Glucosidase Inhibitors.	Amides	13-18	sucrase-isomaltase	Homo sapiens	66-83
34443347-0	2021	Discovery of Amide-Functionalized Benzimidazolium Salts as Potent alpha-Glucosidase Inhibitors.	benzimidazolium salts	34-55	sucrase-isomaltase	Homo sapiens	66-83
34443347-2	2021	The alpha-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars.	Carbohydrates	103-116	sucrase-isomaltase	Homo sapiens	4-21
34462411-11	2021	Alpha glucosidase enzyme interactions were investigated and found that CS-based cryogels can stimulate this enzyme at any CS formulation.	Cesium	71-73	sucrase-isomaltase	Homo sapiens	0-17
34439553-6	2021	Hypoglycemic drugs that reduce glucose fluctuations by decreasing the postprandial rise in blood glucose levels, such as glinides, alpha-glucosidase inhibitors and dipeptidyl peptidase 4 inhibitors, and hypoglycemic drugs that ameliorate insulin sensitivity, such as thiazolidinediones and metformin, are expected to improve or augment endothelial function in patients with diabetes.	Glucose	31-38	sucrase-isomaltase	Homo sapiens	131-148
34439553-6	2021	Hypoglycemic drugs that reduce glucose fluctuations by decreasing the postprandial rise in blood glucose levels, such as glinides, alpha-glucosidase inhibitors and dipeptidyl peptidase 4 inhibitors, and hypoglycemic drugs that ameliorate insulin sensitivity, such as thiazolidinediones and metformin, are expected to improve or augment endothelial function in patients with diabetes.	Glucose	97-104	sucrase-isomaltase	Homo sapiens	131-148
34384326-0	2021	SMILES-based QSAR and molecular docking study of xanthone derivatives as alpha-glucosidase inhibitors.	xanthone	49-57	sucrase-isomaltase	Homo sapiens	73-90
34384326-3	2021	In this study, robust and reliable QSAR models to predict alpha-glucosidase inhibitory potential of xanthone derivatives are developed by the Monte Carlo technique.	xanthone	100-108	sucrase-isomaltase	Homo sapiens	58-75
34451703-9	2021	The DPPH free radical and alpha-glucosidase inhibitions was highest in the leaf ethyl acetate fraction, with IC50 of 6.39 and 4.93 microg/mL, respectively, while the leaf methanol crude extract and butanol fraction exhibited the highest FRAP with 82.95 and 82.17 mmol Fe (II)/g extract.	ethyl acetate	80-93	sucrase-isomaltase	Homo sapiens	26-43
34451703-9	2021	The DPPH free radical and alpha-glucosidase inhibitions was highest in the leaf ethyl acetate fraction, with IC50 of 6.39 and 4.93 microg/mL, respectively, while the leaf methanol crude extract and butanol fraction exhibited the highest FRAP with 82.95 and 82.17 mmol Fe (II)/g extract.	Methanol	171-179	sucrase-isomaltase	Homo sapiens	26-43
34451703-9	2021	The DPPH free radical and alpha-glucosidase inhibitions was highest in the leaf ethyl acetate fraction, with IC50 of 6.39 and 4.93 microg/mL, respectively, while the leaf methanol crude extract and butanol fraction exhibited the highest FRAP with 82.95 and 82.17 mmol Fe (II)/g extract.	Butanols	198-205	sucrase-isomaltase	Homo sapiens	26-43
34443347-2	2021	The alpha-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars.	Sugars	122-128	sucrase-isomaltase	Homo sapiens	4-21
34443347-6	2021	The aim of this study is to explore the alpha-glucosidase inhibition ability of benzimidazolium salts.	benzimidazolium salts	80-101	sucrase-isomaltase	Homo sapiens	40-57
34126149-6	2021	The two polysaccharides have potential for inhibiting alpha-glucosidase and alpha-amylase activities, suppressing HepG-2, A549 and MCF-7 cancer cells proliferation, and activating macrophage RAW 264.7 cells to secret immune cytokines for mediating cellular immune response.	Polysaccharides	8-23	sucrase-isomaltase	Homo sapiens	54-71
34443347-9	2021	Compound 10d was identified as the potent alpha-glucosidase inhibitor among the series with an IC50 value of 14 +- 0.013 muM, which is 4-fold higher than the standard drug, acarbose.	Acarbose	173-181	sucrase-isomaltase	Homo sapiens	42-59
34213618-5	2021	Four strains (Lactiplantibacillus plantarum MG4229, MG4296, MG5025, and Lacticaseibacillus paracasei MG5012) exhibited potent alpha-glucosidase inhibitory (>75%) and alpha-amylase inhibitory (>85%) activities, which were comparable to those of acarbose (>50%; 1000 mug/mL).	Acarbose	244-252	sucrase-isomaltase	Homo sapiens	126-143
34444856-8	2021	In general, the A extracts from solid-liquid extraction with 60% acetone showed stronger inhibitory potential towards a-glucosidase and GPalpha than other extracts whereby no correlation with TPC or TFC were observed.	Acetone	65-72	sucrase-isomaltase	Homo sapiens	118-131
34132726-1	2021	A target-dependent ratiometric fluorescence sensing strategy was designed and fabricated based on a redox reaction for highly sensitive detection of alpha-glucosidase (alpha-Glu) activity and its inhibitor.	Glutamic Acid	174-177	sucrase-isomaltase	Homo sapiens	149-166
34361714-0	2021	Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel alpha-Glucosidase Inhibitor.	hypericin	51-60	sucrase-isomaltase	Homo sapiens	72-89
34361714-1	2021	alpha-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus.	Starch	56-62	sucrase-isomaltase	Homo sapiens	0-17
34361714-2	2021	In this study, the inhibition of hypericin by alpha-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time interaction analysis between hypericin and alpha-glucosidase by surface plasmon resonance (SPR), and molecular docking simulation.	hypericin	33-42	sucrase-isomaltase	Homo sapiens	46-63
34361714-2	2021	In this study, the inhibition of hypericin by alpha-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time interaction analysis between hypericin and alpha-glucosidase by surface plasmon resonance (SPR), and molecular docking simulation.	hypericin	33-42	sucrase-isomaltase	Homo sapiens	193-210
34361714-2	2021	In this study, the inhibition of hypericin by alpha-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time interaction analysis between hypericin and alpha-glucosidase by surface plasmon resonance (SPR), and molecular docking simulation.	hypericin	179-188	sucrase-isomaltase	Homo sapiens	46-63
34361714-2	2021	In this study, the inhibition of hypericin by alpha-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time interaction analysis between hypericin and alpha-glucosidase by surface plasmon resonance (SPR), and molecular docking simulation.	hypericin	179-188	sucrase-isomaltase	Homo sapiens	193-210
34361714-3	2021	The results showed that hypericin was a high potential reversible and competitive alpha-glucosidase inhibitor, with a maximum half inhibitory concentration (IC50) of 4.66 +- 0.27 mg/L.	hypericin	24-33	sucrase-isomaltase	Homo sapiens	82-99
34361714-4	2021	The binding affinities of hypericin with alpha-glucosidase were assessed using an SPR detection system, which indicated that these were strong and fast, with balances dissociation constant (KD) values of 6.56 x 10-5 M and exhibited a slow dissociation reaction.	hypericin	26-35	sucrase-isomaltase	Homo sapiens	41-58
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Hydrogen	13-21	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	hypericin	47-56	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Lysine	99-102	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Serine	108-111	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Glycine	117-120	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Serine	126-129	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Histidine	135-138	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Aspartic Acid	144-147	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Aspartic Acid	157-160	sucrase-isomaltase	Homo sapiens	61-78
34361714-8	2021	This research identified that hypericin, an anthracene ketone compound, could be a novel alpha-glucosidase inhibitor and further applied to the development of potential anti-diabetic drugs.	hypericin	30-39	sucrase-isomaltase	Homo sapiens	89-106
34361714-8	2021	This research identified that hypericin, an anthracene ketone compound, could be a novel alpha-glucosidase inhibitor and further applied to the development of potential anti-diabetic drugs.	anthracene ketone	44-61	sucrase-isomaltase	Homo sapiens	89-106
34073129-10	2021	Molecular modeling studies indicated that dicaffeoylquinic acid showed the highest fitting with free binding energies ( G) of -47.24 and -60.50 Kcal/mol for human alpha-amylase and alpha-glucosidase, respectively confirming its anti-hyperglycemic activity.	caffeoylquinic acid	42-63	sucrase-isomaltase	Homo sapiens	181-198
34931981-9	2021	These natural compounds include numerous flavonoids which help in preventing glucose absorption by preventing the absorption of alpha-amylase and alpha-glucosidase.	Flavonoids	41-51	sucrase-isomaltase	Homo sapiens	146-163
34931981-9	2021	These natural compounds include numerous flavonoids which help in preventing glucose absorption by preventing the absorption of alpha-amylase and alpha-glucosidase.	Glucose	77-84	sucrase-isomaltase	Homo sapiens	146-163
34109464-4	2021	When alpha-glucosidase was introduced into the system, L-ascorbic acid-2-O-alpha-D-glucopyranosyl (AAG) could be hydrolyzed to form ascorbic acid (AA), which can reduce Ce4+ and prevent the oxidation of PPD.	ascorbic acid 2-O-glucoside	55-97	sucrase-isomaltase	Homo sapiens	5-22
34109464-4	2021	When alpha-glucosidase was introduced into the system, L-ascorbic acid-2-O-alpha-D-glucopyranosyl (AAG) could be hydrolyzed to form ascorbic acid (AA), which can reduce Ce4+ and prevent the oxidation of PPD.	aag	99-102	sucrase-isomaltase	Homo sapiens	5-22
34109464-4	2021	When alpha-glucosidase was introduced into the system, L-ascorbic acid-2-O-alpha-D-glucopyranosyl (AAG) could be hydrolyzed to form ascorbic acid (AA), which can reduce Ce4+ and prevent the oxidation of PPD.	Ascorbic Acid	132-145	sucrase-isomaltase	Homo sapiens	5-22
34109464-4	2021	When alpha-glucosidase was introduced into the system, L-ascorbic acid-2-O-alpha-D-glucopyranosyl (AAG) could be hydrolyzed to form ascorbic acid (AA), which can reduce Ce4+ and prevent the oxidation of PPD.	ce4+	169-173	sucrase-isomaltase	Homo sapiens	5-22
34065194-0	2021	Synthesis and alpha-Glucosidase Inhibition Activity of 2-(3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo(e)(1,2)thiazin-2-yl)-N-arylacetamides: An In Silico and Biochemical Approach.	2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo(e)(1,2)thiazin-2-yl)-n-arylacetamides	55-153	sucrase-isomaltase	Homo sapiens	14-31
34065194-3	2021	To lower the blood glucose level, various drugs are employed that block the activity of the alpha-glucosidase enzyme, which&nbsp;is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level.	Glucose	19-26	sucrase-isomaltase	Homo sapiens	92-109
34065194-3	2021	To lower the blood glucose level, various drugs are employed that block the activity of the alpha-glucosidase enzyme, which&nbsp;is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level.	Polysaccharides	176-191	sucrase-isomaltase	Homo sapiens	92-109
34065194-3	2021	To lower the blood glucose level, various drugs are employed that block the activity of the alpha-glucosidase enzyme, which&nbsp;is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level.	Monosaccharides	197-212	sucrase-isomaltase	Homo sapiens	92-109
34065194-3	2021	To lower the blood glucose level, various drugs are employed that block the activity of the alpha-glucosidase enzyme, which&nbsp;is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level.	Glucose	260-267	sucrase-isomaltase	Homo sapiens	92-109
34065194-4	2021	We have synthesized novel 2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo(e)(1,2)thiazin-2-yl)-N-arylacetamides and have screened them for their in silico and in vitro alpha-glucosidase inhibition activity.	2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo(e)(1,2)thiazin-2-yl)-n-arylacetamides	26-124	sucrase-isomaltase	Homo sapiens	181-198
34065194-7	2021	Similarly, these compounds also showed good in vitro alpha-glucosidase inhibitions with IC50 values of 30.65, 18.25, 20.76, 35.14, and 24.24 muM, respectively, which were better than the standard drug, acarbose (IC50 = 58.8 muM).	Acarbose	202-210	sucrase-isomaltase	Homo sapiens	53-70
34064448-3	2021	The 2-amino-5-styrylacetophenones and their 5-styryl-2-aminochalcone derivatives were screened in vitro for their capability to inhibit alpha-glucosidase and/or alpha-amylase activities.	2-amino-5-styrylacetophenones	4-33	sucrase-isomaltase	Homo sapiens	136-153
34069766-10	2021	Molecular docking simulations revealed that luteolin 7-glucoside and apigenin 7-glucoside have particularly strong binding affinities against ChEs, tyrosinase, alpha-amylase and alpha-glucosidase when compared with co-crystallized inhibitors.	luteolin-7-glucoside	44-64	sucrase-isomaltase	Homo sapiens	178-195
34069766-10	2021	Molecular docking simulations revealed that luteolin 7-glucoside and apigenin 7-glucoside have particularly strong binding affinities against ChEs, tyrosinase, alpha-amylase and alpha-glucosidase when compared with co-crystallized inhibitors.	apigetrin	69-89	sucrase-isomaltase	Homo sapiens	178-195
34069325-1	2021	alpha-Glucosidase is considered a prime drug target for Diabetes Mellitus and its inhibitors are used to delay carbohydrate digestion for the treatment of diabetes mellitus.	Carbohydrates	111-123	sucrase-isomaltase	Homo sapiens	0-17
34064448-3	2021	The 2-amino-5-styrylacetophenones and their 5-styryl-2-aminochalcone derivatives were screened in vitro for their capability to inhibit alpha-glucosidase and/or alpha-amylase activities.	5-styryl-2-aminochalcone	44-68	sucrase-isomaltase	Homo sapiens	136-153
35248917-0	2022	Thiazole inhibitors of alpha-glucosidase: Positional isomerism modulates selectivity, enzyme binding and potency of inhibition.	Thiazoles	0-8	sucrase-isomaltase	Homo sapiens	23-40
35617790-0	2022	Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential alpha-glucosidase and SARS-CoV-2 entry inhibitors.	honokiol thioethers	13-32	sucrase-isomaltase	Homo sapiens	83-100
35617790-0	2022	Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential alpha-glucosidase and SARS-CoV-2 entry inhibitors.	1,3,4-oxadiazole	44-60	sucrase-isomaltase	Homo sapiens	83-100
35617790-2	2022	To improve and broaden its biological activity, herein, two series of honokiol thioethers bearing 1,3,4-oxadiazole moieties were prepared and assessed for their alpha-glucosidase and SARS-CoV-2 entry inhibitory activities.	honokiol thioethers	70-89	sucrase-isomaltase	Homo sapiens	161-178
35617790-10	2022	These findings will provide a theoretical basis for the discovery of honokiol derivatives as potential both alpha-glucosidase and SARS-CoV-2 entry inhibitors.	honokiol	69-77	sucrase-isomaltase	Homo sapiens	108-125
35182873-0	2022	New insights suggest isomaltooligosaccharides are slowly digestible carbohydrates, rather than dietary fibers, at constitutive mammalian alpha-glucosidase levels.	isomaltooligosaccharides	21-45	sucrase-isomaltase	Homo sapiens	137-154
35182873-0	2022	New insights suggest isomaltooligosaccharides are slowly digestible carbohydrates, rather than dietary fibers, at constitutive mammalian alpha-glucosidase levels.	Carbohydrates	68-81	sucrase-isomaltase	Homo sapiens	137-154
35248917-2	2022	We present 20 new benzylidene-hydrazinyl-thiazole inhibitors of alpha-glucosidase featuring positional isomerism of the methyl group at 3 and 4 positions of their piperidine ring.	benzylidene-hydrazinyl-thiazole	18-49	sucrase-isomaltase	Homo sapiens	64-81
35248917-2	2022	We present 20 new benzylidene-hydrazinyl-thiazole inhibitors of alpha-glucosidase featuring positional isomerism of the methyl group at 3 and 4 positions of their piperidine ring.	piperidine	163-173	sucrase-isomaltase	Homo sapiens	64-81
35248917-8	2022	Our work provides essential and interesting clues to understanding alpha-glucosidase inhibition by thiazole isomers that would help explore new avenues to designing and developing better alpha-glucosidase inhibitors as antidiabetic drugs.	Thiazoles	99-107	sucrase-isomaltase	Homo sapiens	67-84
35248917-8	2022	Our work provides essential and interesting clues to understanding alpha-glucosidase inhibition by thiazole isomers that would help explore new avenues to designing and developing better alpha-glucosidase inhibitors as antidiabetic drugs.	Thiazoles	99-107	sucrase-isomaltase	Homo sapiens	187-204
35593082-5	2022	The spectrum-effect relationship study by bivariate correlations analysis and orthogonal partial least squares regression revealed that myricitrin (P9), quercitrin (P13), afzelin (P18) and amentoflavone (P24) were more relevant to alpha-glucosidase inhibitory activity.	myricitrin	136-146	sucrase-isomaltase	Homo sapiens	231-248
35243708-10	2022	CONCLUSION: Tomentosin was isolated in high yield from the paste-like extract of I. viscosa compared to the positive controls, it was determined that tomentosin was weakly effective against hCAI, hCAII, AChE and BChE, but thoroughly effective against alpha-glucosidase and alpha-amylase.	tomentosin	12-22	sucrase-isomaltase	Homo sapiens	251-268
35243708-11	2022	These results suggested that tomentosin has alpha-glucosidase and alpha-amylase inhibitor potential.	tomentosin	29-39	sucrase-isomaltase	Homo sapiens	44-61
35606520-1	2022	In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles (9a-n) were designed and synthesized to be evaluated for their anti-alpha-glucosidase activity, focusing on the fact that alpha-glucosidase inhibitors have played a significant role in the management of type 2 diabetes mellitus.	1,2,3-triazoles	62-77	sucrase-isomaltase	Homo sapiens	146-163
35606520-1	2022	In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles (9a-n) were designed and synthesized to be evaluated for their anti-alpha-glucosidase activity, focusing on the fact that alpha-glucosidase inhibitors have played a significant role in the management of type 2 diabetes mellitus.	1,2,3-triazoles	62-77	sucrase-isomaltase	Homo sapiens	200-217
35606520-1	2022	In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles (9a-n) were designed and synthesized to be evaluated for their anti-alpha-glucosidase activity, focusing on the fact that alpha-glucosidase inhibitors have played a significant role in the management of type 2 diabetes mellitus.	9a-n	79-83	sucrase-isomaltase	Homo sapiens	146-163
35606520-1	2022	In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles (9a-n) were designed and synthesized to be evaluated for their anti-alpha-glucosidase activity, focusing on the fact that alpha-glucosidase inhibitors have played a significant role in the management of type 2 diabetes mellitus.	9a-n	79-83	sucrase-isomaltase	Homo sapiens	200-217
35606520-0	2022	Cyanoacetohydrazide linked to 1,2,3-triazole derivatives: a new class of alpha-glucosidase inhibitors.	cyacetacide	0-19	sucrase-isomaltase	Homo sapiens	73-90
35606520-0	2022	Cyanoacetohydrazide linked to 1,2,3-triazole derivatives: a new class of alpha-glucosidase inhibitors.	Triazoles	30-44	sucrase-isomaltase	Homo sapiens	73-90
35606520-1	2022	In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles (9a-n) were designed and synthesized to be evaluated for their anti-alpha-glucosidase activity, focusing on the fact that alpha-glucosidase inhibitors have played a significant role in the management of type 2 diabetes mellitus.	cyacetacide	32-51	sucrase-isomaltase	Homo sapiens	146-163
35606520-1	2022	In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles (9a-n) were designed and synthesized to be evaluated for their anti-alpha-glucosidase activity, focusing on the fact that alpha-glucosidase inhibitors have played a significant role in the management of type 2 diabetes mellitus.	cyacetacide	32-51	sucrase-isomaltase	Homo sapiens	200-217
35593082-5	2022	The spectrum-effect relationship study by bivariate correlations analysis and orthogonal partial least squares regression revealed that myricitrin (P9), quercitrin (P13), afzelin (P18) and amentoflavone (P24) were more relevant to alpha-glucosidase inhibitory activity.	afzelin	171-178	sucrase-isomaltase	Homo sapiens	231-248
35593082-5	2022	The spectrum-effect relationship study by bivariate correlations analysis and orthogonal partial least squares regression revealed that myricitrin (P9), quercitrin (P13), afzelin (P18) and amentoflavone (P24) were more relevant to alpha-glucosidase inhibitory activity.	amentoflavone	189-202	sucrase-isomaltase	Homo sapiens	231-248
35593082-6	2022	The results of alpha-glucosidase inhibitory activity of 21 isolated compounds and molecular docking studies also indicated these flavonoids had potent alpha-glucosidase inhibitory activity.	Flavonoids	129-139	sucrase-isomaltase	Homo sapiens	151-168
35579152-0	2022	Synthesis and Potential Antidiabetic Properties of Curcumin-Based Derivatives: An In Vitro and In Silico Study of alpha-Glucosidase and alpha-Amylase Inhibition.	Curcumin	51-59	sucrase-isomaltase	Homo sapiens	114-131
35631777-6	2022	Both extracts showed the capacity to inhibit alpha-glucosidase, especially the dichloromethane (EC50 = 0.52 mg/mL).	Methylene Chloride	79-94	sucrase-isomaltase	Homo sapiens	45-62
35630550-5	2022	We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and alpha-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group.	ursane	46-52	sucrase-isomaltase	Homo sapiens	147-164
35630550-5	2022	We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and alpha-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group.	pentacyclic	58-69	sucrase-isomaltase	Homo sapiens	147-164
35630550-5	2022	We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and alpha-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group.	Triterpenes	70-83	sucrase-isomaltase	Homo sapiens	147-164
35481063-0	2022	A review on alpha-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes.	transition metal complexes	63-89	sucrase-isomaltase	Homo sapiens	12-29
35572415-12	2022	Acarbose inhibited alpha-glucosidase (p < 0.001) activity with IC50 (4.11 +- 3.47 mug/ml) lower than PHELE (24.41 +- 2.84 mug/ml) and PHEBE (38.81 +- 2.46 mug/ml).	Acarbose	0-8	sucrase-isomaltase	Homo sapiens	19-36
35510404-2	2022	For alpha-glucosidase immobilization, cellulose filter paper was used as the carrier and grafted with amino groups by coating chitosan, then alpha-glucosidase was covalently bonded on the amino-modified carrier via epoxy ring-opening reaction using polyethylene glycol diglycidyl ether as the crosslinker.	Quetol 651	249-285	sucrase-isomaltase	Homo sapiens	4-21
35510404-2	2022	For alpha-glucosidase immobilization, cellulose filter paper was used as the carrier and grafted with amino groups by coating chitosan, then alpha-glucosidase was covalently bonded on the amino-modified carrier via epoxy ring-opening reaction using polyethylene glycol diglycidyl ether as the crosslinker.	Quetol 651	249-285	sucrase-isomaltase	Homo sapiens	141-158
35510404-4	2022	The Michaelis constant of immobilized alpha-glucosidase and half-maximal inhibitory concentration of acarbose were calculated to be 1.12 mM and 0.38 muM, respectively.	Acarbose	101-109	sucrase-isomaltase	Homo sapiens	38-55
35132681-0	2022	New 4-phenylpiperazine-carbodithioate-N-phenylacetamide hybrids: Synthesis, in vitro and in silico evaluations against cholinesterase and alpha-glucosidase enzymes.	4-phenylpiperazine-carbodithioate-n-phenylacetamide	4-55	sucrase-isomaltase	Homo sapiens	138-155
35132681-4	2022	Moreover, all the newly synthesized compounds 6a-n had significant Ki values against alpha-glucosidase when compared with the positive control acarbose.	6-aminonaphthalene-2-sulfonic acid	46-50	sucrase-isomaltase	Homo sapiens	85-102
35132681-4	2022	Moreover, all the newly synthesized compounds 6a-n had significant Ki values against alpha-glucosidase when compared with the positive control acarbose.	Acarbose	143-151	sucrase-isomaltase	Homo sapiens	85-102
35574252-1	2022	The aim of current study was to investigate the inhibitory activities of resveratrol and taxifolin against alpha-amylase, alpha-glucosidase, and DPP-IV enzymes via in vitro analysis which was further validated by in silico studies.	Resveratrol	73-84	sucrase-isomaltase	Homo sapiens	122-139
35574252-1	2022	The aim of current study was to investigate the inhibitory activities of resveratrol and taxifolin against alpha-amylase, alpha-glucosidase, and DPP-IV enzymes via in vitro analysis which was further validated by in silico studies.	taxifolin	89-98	sucrase-isomaltase	Homo sapiens	122-139
35574252-2	2022	The analysis of molecular docking was also done to determine the binding capabilities of resveratrol and taxifolin with alpha-amylase, alpha-glucosidase, and DPP-IV enzymes.	Resveratrol	89-100	sucrase-isomaltase	Homo sapiens	135-152
35574252-2	2022	The analysis of molecular docking was also done to determine the binding capabilities of resveratrol and taxifolin with alpha-amylase, alpha-glucosidase, and DPP-IV enzymes.	taxifolin	105-114	sucrase-isomaltase	Homo sapiens	135-152
35574252-3	2022	Resveratrol and taxifolin having IC50 values, 47.93 +- 5.21 mu M  and 45.86 +- 3.78 mu M  , respectively, showed weaker effect than acarbose (4.6 +- 1.26 mu M  ) on alpha-amylase but showed significant effect to inhibit alpha-glucosidase (32.23 +- .556 mu M  and 31.26 +- .556 mu M  , respectively).	Resveratrol	0-11	sucrase-isomaltase	Homo sapiens	220-237
35574252-3	2022	Resveratrol and taxifolin having IC50 values, 47.93 +- 5.21 mu M  and 45.86 +- 3.78 mu M  , respectively, showed weaker effect than acarbose (4.6 +- 1.26 mu M  ) on alpha-amylase but showed significant effect to inhibit alpha-glucosidase (32.23 +- .556 mu M  and 31.26 +- .556 mu M  , respectively).	taxifolin	16-25	sucrase-isomaltase	Homo sapiens	220-237
35574252-5	2022	Our results illustrated that resveratrol and taxifolin have potential to prevent the metabolism of carbohydrates via inhibition of alpha-amylase and alpha-glucosidase, and prolongs metabolic function of incretin by inhibiting the enzymatic activity of DPP-IV.	Resveratrol	29-40	sucrase-isomaltase	Homo sapiens	149-166
35574252-5	2022	Our results illustrated that resveratrol and taxifolin have potential to prevent the metabolism of carbohydrates via inhibition of alpha-amylase and alpha-glucosidase, and prolongs metabolic function of incretin by inhibiting the enzymatic activity of DPP-IV.	taxifolin	45-54	sucrase-isomaltase	Homo sapiens	149-166
35574252-6	2022	The results of molecular docking have also revealed that resveratrol and taxifolin have significant affinity to bind with alpha-amylase, alpha-glucosidase, and DPP-IV in comparison with standard drugs such as acarbose, miglitol, and diprotin.	Resveratrol	57-68	sucrase-isomaltase	Homo sapiens	137-154
35574252-6	2022	The results of molecular docking have also revealed that resveratrol and taxifolin have significant affinity to bind with alpha-amylase, alpha-glucosidase, and DPP-IV in comparison with standard drugs such as acarbose, miglitol, and diprotin.	taxifolin	73-82	sucrase-isomaltase	Homo sapiens	137-154
35600433-5	2022	Picrasidine-X showed the best binding energy (-7.592) against yeast alpha-glucosidase.	picrasidine	0-11	sucrase-isomaltase	Homo sapiens	68-85
35558871-9	2022	MthPk was also showed maximum inhibition activity against alpha-amylase and alpha-glucosidase with lowest IC50 (.39 +- .41; .61 +- .24), respectively.	mthpk	0-5	sucrase-isomaltase	Homo sapiens	76-93
35497918-5	2022	After 12 weeks of treatment, metformin plus alpha-glucosidase inhibitors were associated with significantly lower levels of 2 hPG, FPG, HbA1c, and HOMA-IR versus metformin alone (P < 0.05).	Metformin	162-171	sucrase-isomaltase	Homo sapiens	44-61
35497918-7	2022	Alpha-glucosidase inhibitors plus metformin for primary T2DM can effectively manage blood glucose and reduce insulin resistance in patients, but the prediction of osteoporosis development remains to be further explored in large sample studies.	Glucose	90-97	sucrase-isomaltase	Homo sapiens	0-17
35481063-3	2022	In this regard, inhibition of alpha-glucosidase, the enzyme responsible for the hydrolysis of carbohydrates in the body has been the main therapeutic approach to the treatment of T2DM.	Carbohydrates	94-107	sucrase-isomaltase	Homo sapiens	30-47
35481063-7	2022	In this respect, in vitro anti-alpha-glucosidase activity of metal complexes has attracted lots of attention and this paper has reviewed the inhibitory activity of first-row transition metal complexes toward alpha-glucosidase and discussed their probable mechanisms of action.	Metals	61-66	sucrase-isomaltase	Homo sapiens	31-48
35481063-7	2022	In this respect, in vitro anti-alpha-glucosidase activity of metal complexes has attracted lots of attention and this paper has reviewed the inhibitory activity of first-row transition metal complexes toward alpha-glucosidase and discussed their probable mechanisms of action.	Metals	185-190	sucrase-isomaltase	Homo sapiens	31-48
35481063-7	2022	In this respect, in vitro anti-alpha-glucosidase activity of metal complexes has attracted lots of attention and this paper has reviewed the inhibitory activity of first-row transition metal complexes toward alpha-glucosidase and discussed their probable mechanisms of action.	Metals	185-190	sucrase-isomaltase	Homo sapiens	208-225
35217120-8	2022	As yeast alpha-glucosidase inhibitors, compounds 15 and 16 also displayed significant activities (IC50 6.2 +- 0.3 and 4.7 +- 0.1 muM, respectively), while compounds 1-6 displayed weaker alpha-glucosidase inhibitory activities, ranging from 49 to 142 muM, compared to acarbose (IC50 665 +- 42 muM).	Acarbose	267-275	sucrase-isomaltase	Homo sapiens	9-26
35458159-4	2022	Enzogenol  demonstrated the ability to inhibit all three enzymes: alpha-amylase enzyme activity (IC50 3.98 +- 0.11 mg/mL), alpha-glucosidase enzyme activity (IC50 13.02 +- 0.28 mug/mL), and DPP-4 enzyme activity (IC50 2.51 +- 0.04 mg/mL).	enzogenol	0-9	sucrase-isomaltase	Homo sapiens	123-140
35255314-2	2022	C-4 Branched LAB alkyl and phenyl derivatives 5La-d showed potent alpha-glucosidase inhibition, particularly against human lysosomal acid alpha-glucosidase; C-4 DAB derivatives 5Da-d, with small alkyl groups, showed enhanced inhibition of rat intestinal maltase and sucrase.	5la-d	46-51	sucrase-isomaltase	Homo sapiens	66-83
35255314-7	2022	The results reported herein provided insights for the design and development of DAB and LAB related alpha-glucosidase inhibitors, and may also contribute to the future development of anti-viral, anti-diabetic and anti-Pompe disease drugs.	1,4-dideoxy-1,4-iminoarabinitol	80-83	sucrase-isomaltase	Homo sapiens	100-117
35362358-9	2022	Amentoflavone showed the strongest binding affinity with alpha-glucosidase, much more potent than reference acarbose.	amentoflavone	0-13	sucrase-isomaltase	Homo sapiens	57-74
35211990-2	2022	When it acts on human skin, microorganisms on the skin surface and part of the stratum corneum produce alpha-glucosidase to sever the glucose bond of diglucosyl gallic acid, thereby converting part of diglucosyl gallic acid into gallic acid, acting on the skin and exerting the excellent effects of diglucosyl gallic acid and gallic acid at the same time.	Glucose	134-141	sucrase-isomaltase	Homo sapiens	103-120
35211990-2	2022	When it acts on human skin, microorganisms on the skin surface and part of the stratum corneum produce alpha-glucosidase to sever the glucose bond of diglucosyl gallic acid, thereby converting part of diglucosyl gallic acid into gallic acid, acting on the skin and exerting the excellent effects of diglucosyl gallic acid and gallic acid at the same time.	Gallic Acid	161-172	sucrase-isomaltase	Homo sapiens	103-120
35211990-2	2022	When it acts on human skin, microorganisms on the skin surface and part of the stratum corneum produce alpha-glucosidase to sever the glucose bond of diglucosyl gallic acid, thereby converting part of diglucosyl gallic acid into gallic acid, acting on the skin and exerting the excellent effects of diglucosyl gallic acid and gallic acid at the same time.	diglucosyl gallic acid	201-223	sucrase-isomaltase	Homo sapiens	103-120
35211990-2	2022	When it acts on human skin, microorganisms on the skin surface and part of the stratum corneum produce alpha-glucosidase to sever the glucose bond of diglucosyl gallic acid, thereby converting part of diglucosyl gallic acid into gallic acid, acting on the skin and exerting the excellent effects of diglucosyl gallic acid and gallic acid at the same time.	Gallic Acid	229-240	sucrase-isomaltase	Homo sapiens	103-120
35211990-2	2022	When it acts on human skin, microorganisms on the skin surface and part of the stratum corneum produce alpha-glucosidase to sever the glucose bond of diglucosyl gallic acid, thereby converting part of diglucosyl gallic acid into gallic acid, acting on the skin and exerting the excellent effects of diglucosyl gallic acid and gallic acid at the same time.	Gallic Acid	310-321	sucrase-isomaltase	Homo sapiens	103-120
35211990-2	2022	When it acts on human skin, microorganisms on the skin surface and part of the stratum corneum produce alpha-glucosidase to sever the glucose bond of diglucosyl gallic acid, thereby converting part of diglucosyl gallic acid into gallic acid, acting on the skin and exerting the excellent effects of diglucosyl gallic acid and gallic acid at the same time.	Gallic Acid	326-337	sucrase-isomaltase	Homo sapiens	103-120
35362358-14	2022	The study suggests that the amentoflavone could be a potential therapeutic drug as an alpha-glucosidase inhibitor and help control postprandial hyperglycemia.Communicated by Ramaswamy H. Sarma.	amentoflavone	28-41	sucrase-isomaltase	Homo sapiens	86-103
35397147-0	2022	Inhibition of alpha-amylase and alpha-glucosidase by Morus australis fruit extract and its components iminosugar, anthocyanin, and glucose.	Anthocyanins	114-125	sucrase-isomaltase	Homo sapiens	32-49
35397147-0	2022	Inhibition of alpha-amylase and alpha-glucosidase by Morus australis fruit extract and its components iminosugar, anthocyanin, and glucose.	Glucose	131-138	sucrase-isomaltase	Homo sapiens	32-49
35397147-1	2022	The inhibition of alpha-amylase and alpha-glucosidase are important for the maintenance of blood glucose level.	Glucose	97-104	sucrase-isomaltase	Homo sapiens	36-53
35397147-6	2022	When the IC50 value of each component and the concentration of each component in the fruit extract were taken into consideration, our results indicated that glucose are involved in the inhibition of alpha-amylase, and 1-DNJ and glucose are involved in the inhibition of alpha-glucosidase.	Glucose	157-164	sucrase-isomaltase	Homo sapiens	270-287
35397147-6	2022	When the IC50 value of each component and the concentration of each component in the fruit extract were taken into consideration, our results indicated that glucose are involved in the inhibition of alpha-amylase, and 1-DNJ and glucose are involved in the inhibition of alpha-glucosidase.	1-dnj	218-223	sucrase-isomaltase	Homo sapiens	270-287
35397147-10	2022	Our results that 1-DNJ and anthocyanin are present in Morus australis fruit and are involved in the inhibition of alpha-amylase and alpha-glucosidase suggest that M. australis fruit is a healthy sweetener.	Anthocyanins	27-38	sucrase-isomaltase	Homo sapiens	132-149
35007516-2	2022	A study by Anderson et al describes an arctic population whose genetic variation in sucrase-isomaltase (SI), an intestinal sucrose breakdown enzyme, confers a healthier anthropometric and metabolic profile in human adults.	Sucrose	123-130	sucrase-isomaltase	Homo sapiens	84-102
35349195-0	2022	Identification of Benzothiazole-Rhodanine Derivatives as alpha-Amylase and alpha-Glucosidase Inhibitors: Design, Synthesis, In-silico, and In-vitro Analysis.	benzothiazole	18-31	sucrase-isomaltase	Homo sapiens	75-92
35007516-2	2022	A study by Anderson et al describes an arctic population whose genetic variation in sucrase-isomaltase (SI), an intestinal sucrose breakdown enzyme, confers a healthier anthropometric and metabolic profile in human adults.	Sucrose	123-130	sucrase-isomaltase	Homo sapiens	104-106
35349195-0	2022	Identification of Benzothiazole-Rhodanine Derivatives as alpha-Amylase and alpha-Glucosidase Inhibitors: Design, Synthesis, In-silico, and In-vitro Analysis.	Rhodanine	32-41	sucrase-isomaltase	Homo sapiens	75-92
35408580-5	2022	The antidiabetic screening of the new nitrobezenesulfochlorination amidoximes found promising samples with in vitro alpha-glucosidase activity higher than the reference drug acarbose.	nitrobezenesulfochlorination amidoximes	38-77	sucrase-isomaltase	Homo sapiens	116-133
35322904-4	2022	While the process of hydrolysis and the subsequent membrane fractionation produced peptides with improved activities in 2,2"-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid radical scavenging ability and oxygen radical absorbance capacity, this process produced no activities in superoxide radical scavenging ability, alpha-amylase, and alpha-glucosidase inhibitory potentials of some of the hydrolysates and peptides fractions.	Peptides	83-91	sucrase-isomaltase	Homo sapiens	340-357
35170953-4	2022	Ulteriorly, benefitting from the greatest catalytic performance and explicit catalytic mechanism of f-FeNC, versatile enzyme cascade-based colorimetric bioassays for ultrasensitive detection of diabetes-related glucose and alpha-glucosidase (alpha-Glu) have been unprecedentedly devised using f-FeNC-triggered chromogenic reaction of 3,3",5,5"-tetramethylbenzidine as an amplifier.	,5,5"-tetramethylbenzidine	338-364	sucrase-isomaltase	Homo sapiens	223-240
35407006-6	2022	In addition, COS-CAT also showed the highest antidiabetic activity of the conjugates, as determined by inhibitory activity toward alpha-amylase, alpha-glucosidase, and pancreatic lipase (p < 0.05).	cos-cat	13-20	sucrase-isomaltase	Homo sapiens	145-185
35280565-0	2022	Exploring the therapeutic potential of benzothiazine-pyrazole hybrid molecules against alpha-glucosidase: Pharmacological and molecular modelling based approach.	benzothiazine	39-52	sucrase-isomaltase	Homo sapiens	87-104
35280565-0	2022	Exploring the therapeutic potential of benzothiazine-pyrazole hybrid molecules against alpha-glucosidase: Pharmacological and molecular modelling based approach.	pyrazole	53-61	sucrase-isomaltase	Homo sapiens	87-104
35280565-2	2022	The current study elucidates the inhibitory potentials of the benzothiazine-pyrazole hybrid series against the alpha-Glucosidase enzyme.	benzothiazine	62-75	sucrase-isomaltase	Homo sapiens	111-128
35280565-2	2022	The current study elucidates the inhibitory potentials of the benzothiazine-pyrazole hybrid series against the alpha-Glucosidase enzyme.	pyrazole	76-84	sucrase-isomaltase	Homo sapiens	111-128
35280565-8	2022	The anti-diabetic analysis revealed that compound ST3 is more active against alpha-Glucosidase with IC50 values 5.8 microM as compared to acarbose which is 58.8 microM.	Acarbose	138-146	sucrase-isomaltase	Homo sapiens	77-94
35215317-0	2022	Magnolol and Luteolin Inhibition of alpha-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies.	magnolol	0-8	sucrase-isomaltase	Homo sapiens	36-53
35170060-0	2022	Inhibitory activity and mechanism of guavinoside B from guava fruits against alpha-glucosidase: Insights by spectroscopy and molecular docking analyses.	guavinoside b	37-50	sucrase-isomaltase	Homo sapiens	77-94
35170060-3	2022	Results indicated that GUB possessed significant inhibition ability on alpha-glucosidase, which was about 10 times that of acarbose.	9-Alpha-L-Lyxofuranosyl-N-(2-Phenylethyl)-9h-Purin-6-Amine	23-26	sucrase-isomaltase	Homo sapiens	71-88
35170060-3	2022	Results indicated that GUB possessed significant inhibition ability on alpha-glucosidase, which was about 10 times that of acarbose.	Acarbose	123-131	sucrase-isomaltase	Homo sapiens	71-88
35170060-5	2022	Fluorescence analysis revealed that GUB quenched the fluorescence of alpha-glucosidase statically, the formation of GUB-alpha-glucosidase complex was a spontaneous and exothermic process, van der Waals forces, hydrogen bonding, and hydrophobic interaction were the predominant driving forces, only one single-binding site on alpha-glucosidase was involved in the binding process.	Hydrogen	210-218	sucrase-isomaltase	Homo sapiens	69-86
35170060-5	2022	Fluorescence analysis revealed that GUB quenched the fluorescence of alpha-glucosidase statically, the formation of GUB-alpha-glucosidase complex was a spontaneous and exothermic process, van der Waals forces, hydrogen bonding, and hydrophobic interaction were the predominant driving forces, only one single-binding site on alpha-glucosidase was involved in the binding process.	Hydrogen	210-218	sucrase-isomaltase	Homo sapiens	120-137
35170060-6	2022	GUB inserted into the hydrophobic pocket of alpha-glucosidase with 11 hydrogen bonds and two pi-pi stacking formed.	Hydrogen	70-78	sucrase-isomaltase	Homo sapiens	44-61
35170060-7	2022	The presence of GUB changed the microenvironment near the fluorescent amino acids of alpha-glucosidase, and the structure of alpha-glucosidase was slightly changed, eventually leading to the decrease of alpha-glucosidase activity.	9-Alpha-L-Lyxofuranosyl-N-(2-Phenylethyl)-9h-Purin-6-Amine	16-19	sucrase-isomaltase	Homo sapiens	85-102
35170060-7	2022	The presence of GUB changed the microenvironment near the fluorescent amino acids of alpha-glucosidase, and the structure of alpha-glucosidase was slightly changed, eventually leading to the decrease of alpha-glucosidase activity.	9-Alpha-L-Lyxofuranosyl-N-(2-Phenylethyl)-9h-Purin-6-Amine	16-19	sucrase-isomaltase	Homo sapiens	125-142
35170060-7	2022	The presence of GUB changed the microenvironment near the fluorescent amino acids of alpha-glucosidase, and the structure of alpha-glucosidase was slightly changed, eventually leading to the decrease of alpha-glucosidase activity.	9-Alpha-L-Lyxofuranosyl-N-(2-Phenylethyl)-9h-Purin-6-Amine	16-19	sucrase-isomaltase	Homo sapiens	203-220
35170060-12	2022	Studies have shown that GUB could reversibly inhibit the activity of alpha-glucosidase, and its inhibitory ability was about 10 times that of acarbose.	9-Alpha-L-Lyxofuranosyl-N-(2-Phenylethyl)-9h-Purin-6-Amine	24-27	sucrase-isomaltase	Homo sapiens	69-86
35170060-12	2022	Studies have shown that GUB could reversibly inhibit the activity of alpha-glucosidase, and its inhibitory ability was about 10 times that of acarbose.	Acarbose	142-150	sucrase-isomaltase	Homo sapiens	69-86
35083996-4	2022	The hypoglycaemic effect of AABP-2B was evaluated by its inhibition of alpha-glucosidase activities and insulin resistance in a HepG2 cell model.	aabp-2b	28-35	sucrase-isomaltase	Homo sapiens	71-88
35209111-10	2022	The pharmacokinetic estimations and protein-ligand molecular docking results with the support of molecular dynamic simulation trajectories at 100 ns suggested that two bioactive compounds-dihydrocatalpol and leucosceptoside A-from the EtOAc fraction presented excellent drug-like properties and stable conformations; hence, these bioactive compounds could be potential inhibitors of alpha-glucosidase enzyme based on intermolecular interactions with significant residues, docking score, and binding free energy estimation.	Dihydrocatalpol	188-203	sucrase-isomaltase	Homo sapiens	383-400
35209111-10	2022	The pharmacokinetic estimations and protein-ligand molecular docking results with the support of molecular dynamic simulation trajectories at 100 ns suggested that two bioactive compounds-dihydrocatalpol and leucosceptoside A-from the EtOAc fraction presented excellent drug-like properties and stable conformations; hence, these bioactive compounds could be potential inhibitors of alpha-glucosidase enzyme based on intermolecular interactions with significant residues, docking score, and binding free energy estimation.	Leucosceptoside A	208-225	sucrase-isomaltase	Homo sapiens	383-400
35215317-0	2022	Magnolol and Luteolin Inhibition of alpha-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies.	Luteolin	13-21	sucrase-isomaltase	Homo sapiens	36-53
35015798-0	2022	Inhibitory activity of flavonoids against human sucrase-isomaltase (alpha-glucosidase) activity in a Caco-2/TC7 cellular model.	Flavonoids	23-33	sucrase-isomaltase	Homo sapiens	68-85
35215317-2	2022	This research aimed to determine the inhibitory activity of magnolol and luteolin on alpha-glucosidase activity.	magnolol	60-68	sucrase-isomaltase	Homo sapiens	85-102
35215317-2	2022	This research aimed to determine the inhibitory activity of magnolol and luteolin on alpha-glucosidase activity.	Luteolin	73-81	sucrase-isomaltase	Homo sapiens	85-102
35215317-8	2022	Synchronous fluorescence revealed that magnolol interacted with the target, influencing the microenvironment around tyrosine residues, and circular dichroism explained a rearrangement of the secondary structure of alpha-glucosidase from the initial alpha-helix to the final conformation enriched with beta-sheet and random coil.	magnolol	39-47	sucrase-isomaltase	Homo sapiens	214-231
35015798-0	2022	Inhibitory activity of flavonoids against human sucrase-isomaltase (alpha-glucosidase) activity in a Caco-2/TC7 cellular model.	caco-2	101-107	sucrase-isomaltase	Homo sapiens	68-85
35015798-4	2022	The present study evaluates the inhibitory activity of a selected group of flavonoids against human sucrase-isomaltase (SI), the alpha-glucosidase found in Caco-2/TC7 cells.	Flavonoids	75-85	sucrase-isomaltase	Homo sapiens	129-146
35215317-10	2022	Altogether, the data propose magnolol, for the first time, as a potential alpha-glucosidase inhibitor and add further evidence to the inhibitory role of luteolin.	magnolol	29-37	sucrase-isomaltase	Homo sapiens	74-91
34989743-0	2022	Inhibition of alpha-glucosidase by trilobatin and its mechanism: kinetics, interaction mechanism and molecular docking.	trilobatin	35-45	sucrase-isomaltase	Homo sapiens	14-31
34750286-2	2022	LRCC5314 exhibited very stable survival at pH 2 and in 0.2% bile acid with 89.9% adhesion to Caco-2 intestinal epithelial cells after treatment for 2 h. LRCC5314 also inhibited the activities of alpha-amylase and alpha-glucosidase, which are involved in elevating postprandial blood glucose levels, by approximately 72.9% and 51.2%, respectively.	lrcc5314	0-8	sucrase-isomaltase	Homo sapiens	213-230
34750286-2	2022	LRCC5314 exhibited very stable survival at pH 2 and in 0.2% bile acid with 89.9% adhesion to Caco-2 intestinal epithelial cells after treatment for 2 h. LRCC5314 also inhibited the activities of alpha-amylase and alpha-glucosidase, which are involved in elevating postprandial blood glucose levels, by approximately 72.9% and 51.2%, respectively.	lrcc5314	153-161	sucrase-isomaltase	Homo sapiens	213-230
34989743-4	2022	In this study, the inhibitory activity and mechanism of trilobatin on alpha-glucosidase were investigated using multispectroscopic and molecular docking techniques.	trilobatin	56-66	sucrase-isomaltase	Homo sapiens	70-87
34989743-5	2022	The kinetic analysis showed that trilobatin reversibly inhibited alpha-glucosidase in a noncompetitive-type manner and the value of IC50 was 0.24 +- 0.02 mM.	trilobatin	33-43	sucrase-isomaltase	Homo sapiens	65-82
34989743-6	2022	The analysis of fluorescence spectra demonstrated that the formation of the trilobatin-alpha-glucosidase complex was driven mainly by hydrogen bonding and van der Waals forces, resulting in the conformational changes of alpha-glucosidase.	Hydrogen	134-142	sucrase-isomaltase	Homo sapiens	87-104
34989743-6	2022	The analysis of fluorescence spectra demonstrated that the formation of the trilobatin-alpha-glucosidase complex was driven mainly by hydrogen bonding and van der Waals forces, resulting in the conformational changes of alpha-glucosidase.	Hydrogen	134-142	sucrase-isomaltase	Homo sapiens	220-237
34989743-7	2022	Fourier transform infrared spectroscopy (FT-IR) and circular dichroism (CD) measurements suggested that the interaction could change the micro-environment and conformation of alpha-glucosidase affected by trilobatin.	trilobatin	205-215	sucrase-isomaltase	Homo sapiens	175-192
34989743-8	2022	Molecular docking analysis determined the exact binding sites of trilobatin on alpha-glucosidase.	trilobatin	65-75	sucrase-isomaltase	Homo sapiens	79-96
34989743-9	2022	These results indicated that trilobatin is a strong alpha-glucosidase inhibitor, thus it could be conducive to ameliorate T2DM.	trilobatin	29-39	sucrase-isomaltase	Homo sapiens	52-69
35050002-5	2022	The majority of sorbicillinoids have been reported from fungi genera such as Acremonium, Penicillium, Trichoderma, and Ustilaginoidea, with some sorbicillinoids exhibiting cytotoxic, antimicrobial, anti-inflammatory, phytotoxic, and alpha-glucosidase inhibitory activities.	sorbicillinoids	16-31	sucrase-isomaltase	Homo sapiens	233-250
35128286-0	2022	Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and alpha-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies.	1,3,5-triaryl-2-pyrazoline	28-54	sucrase-isomaltase	Homo sapiens	107-124
35128286-1	2022	In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (2a-2q) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and alpha-glucosidase inhibitory activities.	1,3,5-triaryl-2-pyrazolines	42-69	sucrase-isomaltase	Homo sapiens	213-230
35128286-1	2022	In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (2a-2q) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and alpha-glucosidase inhibitory activities.	2a-2q	71-76	sucrase-isomaltase	Homo sapiens	213-230
35128286-6	2022	Among the synthesized pyrazolines, the compounds 2c, 2k, 2m, and 2o exhibited excellent alpha-glucosidase inhibitory activity with the lowest IC50 values of 212.52 +- 1.31, 237.26 +- 1.28, 138.35 +- 1.32, and 114.57 +- 1.35 muM, respectively, as compared to the standard acarbose (IC50 = 375.82 +- 1.76 muM).	pyrazolines	22-33	sucrase-isomaltase	Homo sapiens	88-105
35161257-7	2022	The inhibition of alpha-glucosidase was strongly positively correlated with the total and condensed tannins, procyanidin dimers and procyanidin tetramer, and was very strongly correlated with chlorogenic acid.	procyanidin	109-120	sucrase-isomaltase	Homo sapiens	18-35
35161257-7	2022	The inhibition of alpha-glucosidase was strongly positively correlated with the total and condensed tannins, procyanidin dimers and procyanidin tetramer, and was very strongly correlated with chlorogenic acid.	procyanidin	132-143	sucrase-isomaltase	Homo sapiens	18-35
35161257-7	2022	The inhibition of alpha-glucosidase was strongly positively correlated with the total and condensed tannins, procyanidin dimers and procyanidin tetramer, and was very strongly correlated with chlorogenic acid.	Chlorogenic Acid	192-208	sucrase-isomaltase	Homo sapiens	18-35
35040740-2	2022	In the gastrointestinal tract, starches are hydrolyzed into glucose by alpha-amylase and alpha-glucosidase, which leads to a postprandial glucose elevation.	Starch	31-39	sucrase-isomaltase	Homo sapiens	89-106
35040740-2	2022	In the gastrointestinal tract, starches are hydrolyzed into glucose by alpha-amylase and alpha-glucosidase, which leads to a postprandial glucose elevation.	Glucose	60-67	sucrase-isomaltase	Homo sapiens	89-106
35040740-2	2022	In the gastrointestinal tract, starches are hydrolyzed into glucose by alpha-amylase and alpha-glucosidase, which leads to a postprandial glucose elevation.	Glucose	138-145	sucrase-isomaltase	Homo sapiens	89-106
35276777-7	2022	Biscuits showed significant increase in ABTS antioxidant capacity and yogurt showed increased alpha-glucosidase inhibition capacity by the addition of TGS (p < 0.05).	6-thioguanosine	151-154	sucrase-isomaltase	Homo sapiens	94-111
35056861-0	2022	Anti-alpha-Glucosidase and Antiglycation Activities of alpha-Mangostin and New Xanthenone Derivatives: Enzymatic Kinetics and Mechanistic Insights through In Vitro Studies.	mangostin	55-70	sucrase-isomaltase	Homo sapiens	5-22
35056861-3	2022	This research aims to evaluate the inhibitory activity of alpha-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on alpha-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose molecules, promoting the postprandial glycemic peak.	mangostin	58-73	sucrase-isomaltase	Homo sapiens	165-182
35056861-3	2022	This research aims to evaluate the inhibitory activity of alpha-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on alpha-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose molecules, promoting the postprandial glycemic peak.	xanthone	93-103	sucrase-isomaltase	Homo sapiens	165-182
35056861-3	2022	This research aims to evaluate the inhibitory activity of alpha-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on alpha-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose molecules, promoting the postprandial glycemic peak.	Oligosaccharides	239-255	sucrase-isomaltase	Homo sapiens	165-182
35056861-3	2022	This research aims to evaluate the inhibitory activity of alpha-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on alpha-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose molecules, promoting the postprandial glycemic peak.	Glucose	261-268	sucrase-isomaltase	Homo sapiens	165-182
35056861-9	2022	The data highlighted the anti-alpha-glucosidase activity of alpha-mangostin together with its protective effects on protein glycation and oxidation damage.	mangostin	60-75	sucrase-isomaltase	Homo sapiens	30-47
35056163-0	2022	Identification of Cyclic Sulfonamides with an N-Arylacetamide Group as alpha-Glucosidase and alpha-Amylase Inhibitors: Biological Evaluation and Molecular Modeling.	cyclic sulfonamides	18-37	sucrase-isomaltase	Homo sapiens	71-88
35056163-0	2022	Identification of Cyclic Sulfonamides with an N-Arylacetamide Group as alpha-Glucosidase and alpha-Amylase Inhibitors: Biological Evaluation and Molecular Modeling.	n-arylacetamide	46-61	sucrase-isomaltase	Homo sapiens	71-88
35056163-2	2022	alpha-Glucosidase inhibitors (AGIs) and alpha-amylase inhibitors (AAIs) block the function of digestive enzymes, which delays the carbohydrate hydrolysis process and ultimately helps to control the postprandial hyperglycemia.	Carbohydrates	130-142	sucrase-isomaltase	Homo sapiens	0-17
35056163-3	2022	Diversified 2-(3-(3-methoxybenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo(e)(1,2)thiazin-2-yl)-N-arylacetamides were synthesized and evaluated for their in vitro inhibitory potential against alpha-glucosidase and alpha-amylase enzymes.	diversified	0-11	sucrase-isomaltase	Homo sapiens	184-201
35056163-4	2022	The compounds with chloro, bromo and methyl substituents demonstrated good inhibition of alpha-glucosidase enzymes having IC50 values in the range of 25.88-46.25 muM, which are less than the standard drug, acarbose (IC50 = 58.8 muM).	Hydrochloric Acid	19-25	sucrase-isomaltase	Homo sapiens	89-106
35056163-4	2022	The compounds with chloro, bromo and methyl substituents demonstrated good inhibition of alpha-glucosidase enzymes having IC50 values in the range of 25.88-46.25 muM, which are less than the standard drug, acarbose (IC50 = 58.8 muM).	Bromine	27-32	sucrase-isomaltase	Homo sapiens	89-106
35056163-4	2022	The compounds with chloro, bromo and methyl substituents demonstrated good inhibition of alpha-glucosidase enzymes having IC50 values in the range of 25.88-46.25 muM, which are less than the standard drug, acarbose (IC50 = 58.8 muM).	Acarbose	206-214	sucrase-isomaltase	Homo sapiens	89-106
35056163-6	2022	In addition, the most potent compound, N-(4-bromophenyl)-2-(4-hydroxy-3-(3-methoxybenzoyl)-1,1-dioxido-2H-benzo(e)(1,2)thiazin-2-yl)acetamide (12i), was found to be a non-competitive and competitive inhibitor of alpha-glucosidase and alpha-amylase enzymes, respectively, during kinetic studies.	4-(4-methylpiperazin-1-yl)quinazoline	143-146	sucrase-isomaltase	Homo sapiens	212-229
35050002-5	2022	The majority of sorbicillinoids have been reported from fungi genera such as Acremonium, Penicillium, Trichoderma, and Ustilaginoidea, with some sorbicillinoids exhibiting cytotoxic, antimicrobial, anti-inflammatory, phytotoxic, and alpha-glucosidase inhibitory activities.	sorbicillinoids	145-160	sucrase-isomaltase	Homo sapiens	233-250
34874372-0	2022	Green preparation of holocellulose nanocrystals from burdock and their inhibitory effects against alpha-amylase and alpha-glucosidase.	holocellulose	21-34	sucrase-isomaltase	Homo sapiens	116-133
34874372-1	2022	In this work, holocellulose nanocrystals (hCNCs) were isolated from burdock insoluble dietary fiber (IDF) by enzymatic hydrolysis and ultrasonic treatment and their inhibitory effects against alpha-amylase and alpha-glucosidase were investigated.	holocellulose	14-27	sucrase-isomaltase	Homo sapiens	210-227
34874372-3	2022	Steady-state fluorescence studies suggested that static complexes were formed between hCNCs and alpha-amylase or alpha-glucosidase via a spontaneous and endothermic approach, which was driven by both hydrophobic interactions and hydrogen bonding.	hcncs	86-91	sucrase-isomaltase	Homo sapiens	113-130
34874372-3	2022	Steady-state fluorescence studies suggested that static complexes were formed between hCNCs and alpha-amylase or alpha-glucosidase via a spontaneous and endothermic approach, which was driven by both hydrophobic interactions and hydrogen bonding.	Hydrogen	229-237	sucrase-isomaltase	Homo sapiens	113-130
35110468-1	2022	In this study, it is recorded the inhibition effect of Thalassiolin B on aldose reductase, alpha-glucosidase and alpha-amylase enzymes.	thalassiolin B	55-69	sucrase-isomaltase	Homo sapiens	91-108