PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35400495-2	2022	Here we describe the pharmacological data for SLN360, a GalNAc-conjugated siRNA targeting LPA, designed to address this unmet medical need.	sln360	46-52	apolipoprotein(a)	Macaca fascicularis	90-93
35400495-3	2022	METHODS: SLN360 was tested in vitro for LPA knockdown in primary hepatocytes.	sln360	9-15	apolipoprotein(a)	Macaca fascicularis	40-43
35400495-6	2022	RESULTS: In vitro, the SLN360 sequence potently reduces LPA mRNA in primary cynomolgus and human hepatocytes, while no effect was observed on the expression of APOB or PLG.	sln360	23-29	apolipoprotein(a)	Macaca fascicularis	56-59
35400495-11	2022	CONCLUSIONS: SLN360 induces a sustained reduction in serum Lp(a) levels in cynomolgus monkeys following subcutaneous dosing.	sln360	13-19	apolipoprotein(a)	Macaca fascicularis	59-64
35400495-12	2022	SLN360 has potential to address the unmet need of Lp(a) reduction in cardiovascular diseases.	sln360	0-6	apolipoprotein(a)	Macaca fascicularis	50-55
9299449-2	1997	Since Lp(a) is produced by a disulfide linkage between apolipoprotein(a) [apo(a)] and apolipoproteinB-100 (apoB-100) of low density lipoprotein (LDL) on the hepatocyte surface, modulation of either particle may be useful in lowering Lp(a).	Disulfides	29-38	apolipoprotein(a)	Macaca fascicularis	6-11
9299449-2	1997	Since Lp(a) is produced by a disulfide linkage between apolipoprotein(a) [apo(a)] and apolipoproteinB-100 (apoB-100) of low density lipoprotein (LDL) on the hepatocyte surface, modulation of either particle may be useful in lowering Lp(a).	Disulfides	29-38	apolipoprotein(a)	Macaca fascicularis	233-238
9299449-5	1997	These results demonstrate that retinoids lower Lp(a) levels by decreasing apo(a) through its cognate mRNA.	Retinoids	31-40	apolipoprotein(a)	Macaca fascicularis	47-52
8018102-5	1994	The mean Lp(a) level for these animals during the SAT diet (13.4 +/- 2.4 mg/dl) was significantly greater as compared with those observed during the MONO (8.6 +/- 2.2 mg/dl, P < 0.0003) and POLY (9.3 +/- 2.1 mg/dl, P < 0.002) diets, while the difference noted between the MONO and POLY diets was nonsignificant.	poly	193-197	apolipoprotein(a)	Macaca fascicularis	9-14
8018102-7	1994	Our data demonstrate that the substitution of dietary SATs with either MONOs or POLYs result in significant reductions of Lp(a) levels in these monkeys.	Mono-S	71-76	apolipoprotein(a)	Macaca fascicularis	122-127
8018102-7	1994	Our data demonstrate that the substitution of dietary SATs with either MONOs or POLYs result in significant reductions of Lp(a) levels in these monkeys.	polys	80-85	apolipoprotein(a)	Macaca fascicularis	122-127
8018102-8	1994	However, only the MONO diet significantly decreased hepatic apo(a) mRNA levels relative to the SAT diet, suggesting that dietary MONOs and POLYs may differ in the manner by which they regulate plasma Lp(a) levels.	polys	139-144	apolipoprotein(a)	Macaca fascicularis	200-205
9544734-3	1998	This investigation was carried out to determine the effect of CI-1011, a potent lipid regulator in rodents, on Lp(a) and other lipid parameters in cynomolgus monkeys (Macaca fascicularis).	avasimibe	62-69	apolipoprotein(a)	Macaca fascicularis	111-116
9544734-13	1998	Treatment of cynomolgus monkey primary hepatocyte cultures with CI-1011 resulted in a dose-dependent inhibition of Lp(a) levels suggesting a direct hepatic effect of the compound.	avasimibe	64-71	apolipoprotein(a)	Macaca fascicularis	115-120
9544734-15	1998	These results demonstrate that CI-1011 effectively decreases Lp(a) levels both in vivo and in vitro.	avasimibe	31-38	apolipoprotein(a)	Macaca fascicularis	61-66
7666007-3	1995	Lp[a] reduction was directly related to blood gemfibrozil concentration (range 36-428 microM, r = 0.969) and occurred without concomitant changes in apolipoprotein B.	Gemfibrozil	46-57	apolipoprotein(a)	Macaca fascicularis	0-4
7666007-7	1995	However, both Lp[a] and apo[a] mRNA in primary cynomolgus monkey hepatocytes were coordinately lowered in a dose-dependent fashion by gemfibrozil.	Gemfibrozil	134-145	apolipoprotein(a)	Macaca fascicularis	14-18
7666007-8	1995	Thus, Lp[a] can be regulated by gemfibrozil at the level of apo[a] mRNA expression.	Gemfibrozil	32-43	apolipoprotein(a)	Macaca fascicularis	6-10