PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Xylose	64-70	prion like protein doppel	Homo sapiens	25-28
23483050-1	2013	Our group has recently isolated and identified novel yellow compounds named dilysyl-dipyrrolones A (DPL A; 1) and B (DPL B; 2) in a heated aqueous solution containing xylose and lysine under weakly acidic conditions.	6-((1-(5-amino-1-carboxypentyl)-3-hydroxypyrrol-2-yl)-2-methylidene-5-methyl-1,2H-pyrrol-3-one-1-ly)-2-aminohexanoic acid	76-98	prion like protein doppel	Homo sapiens	100-103
23483050-1	2013	Our group has recently isolated and identified novel yellow compounds named dilysyl-dipyrrolones A (DPL A; 1) and B (DPL B; 2) in a heated aqueous solution containing xylose and lysine under weakly acidic conditions.	6-((1-(5-amino-1-carboxypentyl)-3-hydroxypyrrol-2-yl)-2-methylidene-5-methyl-1,2H-pyrrol-3-one-1-ly)-2-aminohexanoic acid	76-98	prion like protein doppel	Homo sapiens	117-120
23483050-1	2013	Our group has recently isolated and identified novel yellow compounds named dilysyl-dipyrrolones A (DPL A; 1) and B (DPL B; 2) in a heated aqueous solution containing xylose and lysine under weakly acidic conditions.	Xylose	167-173	prion like protein doppel	Homo sapiens	117-120
23483050-1	2013	Our group has recently isolated and identified novel yellow compounds named dilysyl-dipyrrolones A (DPL A; 1) and B (DPL B; 2) in a heated aqueous solution containing xylose and lysine under weakly acidic conditions.	Lysine	178-184	prion like protein doppel	Homo sapiens	117-120
23483050-3	2013	To estimate the formation mechanism of DPL derivatives, (13)C-labeled DPLs were prepared and analyzed with LC/MS and NMR.	dpls	70-74	prion like protein doppel	Homo sapiens	39-42
23483050-4	2013	(13)C-labeling experiments using [1-(13)C] ribose showed that the formation pathway of DPL C was different from those of DPLs A and B.	Ribose	43-49	prion like protein doppel	Homo sapiens	87-90
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Lysine	78-84	prion like protein doppel	Homo sapiens	124-127
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	methine	106-113	prion like protein doppel	Homo sapiens	124-127
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Ribose	57-63	prion like protein doppel	Homo sapiens	124-127
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Acetic Acid	164-175	prion like protein doppel	Homo sapiens	124-127
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Alanine	95-102	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Arginine	104-112	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Aspartic Acid	114-127	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Glutamic Acid	129-142	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Isoleucine	144-154	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Leucine	147-154	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Phenylalanine	165-178	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Serine	180-186	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Valine	192-198	prion like protein doppel	Homo sapiens	25-28
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Lysine	218-224	prion like protein doppel	Homo sapiens	25-28
20411530-4	2010	Dpl is able to bind at least one copper ion, and the specific metal-binding site has been identified as the histidine residue at the beginning of the third helical region.	Copper	33-39	prion like protein doppel	Homo sapiens	0-3
20411530-4	2010	Dpl is able to bind at least one copper ion, and the specific metal-binding site has been identified as the histidine residue at the beginning of the third helical region.	Histidine	108-117	prion like protein doppel	Homo sapiens	0-3
20411530-8	2010	Herein, the synthesis of the human Dpl peptide fragment hDpl(122-139) (Ac-KPDNKLHQQVLWRLVQEL-NH(2)) and its copper(II) complex species are reported.	Copper	108-115	prion like protein doppel	Homo sapiens	35-38
20411530-11	2010	This peptide was used to highlight the role of the carboxylate group on both the conformation preference of the Dpl fragment and its copper(II) coordination features.	carboxylate	51-62	prion like protein doppel	Homo sapiens	112-115
20411530-21	2010	To elaborate on the potential role of copper(II) in the recently reported interaction between the PrP(C) and Dpl, the affinity of the copper(II) complexes towards the prion N terminus domain and the binding site of Dpl was reported.	Copper	38-44	prion like protein doppel	Homo sapiens	109-112
20411530-21	2010	To elaborate on the potential role of copper(II) in the recently reported interaction between the PrP(C) and Dpl, the affinity of the copper(II) complexes towards the prion N terminus domain and the binding site of Dpl was reported.	Copper	38-44	prion like protein doppel	Homo sapiens	215-218
19728151-3	2010	MTT assays showed the cell viabilities of the human neuroblastoma cell line SH-SY5Y receiving Dpl and PrPDelta32-121 expressing plasmids were remarkably lower.	monooxyethylene trimethylolpropane tristearate	0-3	prion like protein doppel	Homo sapiens	94-97
19237200-0	2009	Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein.	cupric ion	0-10	prion like protein doppel	Homo sapiens	87-93
20981146-5	2010	Importantly, Dpl exhibited different cellular localizations and altered glycan moieties composition, depending on the tumor grade.	Polysaccharides	72-78	prion like protein doppel	Homo sapiens	13-16
19237200-1	2009	Copper(II) complexes of the peptide fragment (Dpl122-130) encompassing the sequence 122-130 of human doppel protein were characterized by potentiometric, UV-Visible, CD and EPR spectroscopic methods.	cupric ion	0-10	prion like protein doppel	Homo sapiens	101-107
19237200-4	2009	This copper(II) complex displayed EPR parameters very similar to those of the analogous complex with the whole doppel protein.	cupric ion	5-15	prion like protein doppel	Homo sapiens	111-117
19237200-6	2009	The comparison of Cu-Dpl122-130 binding constant values with those of the prion peptide fragments (PrP106-114), showed that doppel peptide had a higher metal binding affinity at acidic pH whereas the prion peptide fragment binds the metal tightly at physiological pH.	cu-dpl122	18-27	prion like protein doppel	Homo sapiens	124-130
19237200-6	2009	The comparison of Cu-Dpl122-130 binding constant values with those of the prion peptide fragments (PrP106-114), showed that doppel peptide had a higher metal binding affinity at acidic pH whereas the prion peptide fragment binds the metal tightly at physiological pH.	Metals	152-157	prion like protein doppel	Homo sapiens	124-130
19237200-6	2009	The comparison of Cu-Dpl122-130 binding constant values with those of the prion peptide fragments (PrP106-114), showed that doppel peptide had a higher metal binding affinity at acidic pH whereas the prion peptide fragment binds the metal tightly at physiological pH.	Metals	233-238	prion like protein doppel	Homo sapiens	124-130
17894227-5	2007	The recombinant human Doppel protein (rhDpl) was expressed as inclusion bodies after IPTG induction, with the yield of more than 60% of total bacterial proteins.	Isopropyl Thiogalactoside	85-89	prion like protein doppel	Homo sapiens	22-28
18607068-7	2008	Additionally, Dpl showed altered expression and traffic using the acidotropic agent ammonium chloride, leading to the accumulation of Dpl in nascent exocytic vesicles.	Ammonium Chloride	84-101	prion like protein doppel	Homo sapiens	14-17
18607068-7	2008	Additionally, Dpl showed altered expression and traffic using the acidotropic agent ammonium chloride, leading to the accumulation of Dpl in nascent exocytic vesicles.	Ammonium Chloride	84-101	prion like protein doppel	Homo sapiens	134-137
17921302-8	2007	The purified PrnF protein catalyzes reduction of flavin adenine dinucleotide (FAD) by NADH with a k(cat) of 65 s(-1) (K(m) = 3.2 muM for FAD and 43.1 muM for NADH) and supplies reduced FAD to the PrnD oxygenase component.	Flavin-Adenine Dinucleotide	49-76	prion like protein doppel	Homo sapiens	196-200
17921302-8	2007	The purified PrnF protein catalyzes reduction of flavin adenine dinucleotide (FAD) by NADH with a k(cat) of 65 s(-1) (K(m) = 3.2 muM for FAD and 43.1 muM for NADH) and supplies reduced FAD to the PrnD oxygenase component.	Flavin-Adenine Dinucleotide	78-81	prion like protein doppel	Homo sapiens	196-200
17921302-8	2007	The purified PrnF protein catalyzes reduction of flavin adenine dinucleotide (FAD) by NADH with a k(cat) of 65 s(-1) (K(m) = 3.2 muM for FAD and 43.1 muM for NADH) and supplies reduced FAD to the PrnD oxygenase component.	NAD	86-90	prion like protein doppel	Homo sapiens	196-200
17921302-9	2007	Unlike other known reductases in two-component oxygenase systems, PrnF strictly requires NADH as an electron donor to reduce FAD and requires unusual protein-protein interaction with the PrnD component for the efficient transfer of reduced FAD.	Flavin-Adenine Dinucleotide	240-243	prion like protein doppel	Homo sapiens	187-191
18940210-7	2009	Interestingly, DPL prepared with Lipofectin or 1, 2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP) exhibited enhanced transfection in the presence of serum in MCF-7 and HepG2 cells.	1,2-dielaidoylphosphatidylethanolamine	33-43	prion like protein doppel	Homo sapiens	15-18
18940210-7	2009	Interestingly, DPL prepared with Lipofectin or 1, 2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP) exhibited enhanced transfection in the presence of serum in MCF-7 and HepG2 cells.	1,2-dioleoyloxy-3-(trimethylammonium)propane	47-88	prion like protein doppel	Homo sapiens	15-18
18940210-7	2009	Interestingly, DPL prepared with Lipofectin or 1, 2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP) exhibited enhanced transfection in the presence of serum in MCF-7 and HepG2 cells.	1,2-dioleoyloxy-3-(trimethylammonium)propane	90-95	prion like protein doppel	Homo sapiens	15-18
19129949-8	2009	Furthermore, binding of copper ion could enhance the antagonizing effect of PrP on Dpl-induced cytotoxicity.	Copper	24-30	prion like protein doppel	Homo sapiens	83-86
17921302-6	2007	Here we report the use of bioinformatic and biochemical tools to identify and characterize the reductase component (PrnF) involved in the PrnD-catalyzed unusual arylamine oxidation.	aniline	161-170	prion like protein doppel	Homo sapiens	138-142
35220018-0	2022	Targeting angiogenic growth factors using therapeutic glycosaminoglycans on doppel-expressing endothelial cells for blocking angiogenic signaling in cancer.	Glycosaminoglycans	54-72	prion like protein doppel	Homo sapiens	76-82
15203115-7	2004	The results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane, and get internalized together after ganglioside cross-linking by cholera toxin or addition of an antibody against only one of the proteins.	Gangliosides	126-137	prion like protein doppel	Homo sapiens	29-35
12200435-4	2002	Human Dpl appears to be a glycosylphosphatidylinositol-anchored glycoprotein with N- and O-linked sugars.	n- and o-linked sugars	82-104	prion like protein doppel	Homo sapiens	6-9
34737762-7	2021	The miR-222-3p was highly expressed, probably leading to low NEGR1 and high PRND expression in THCA tissues.	mir-222-3p	4-14	prion like protein doppel	Homo sapiens	76-80
15218028-0	2004	Copper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein.	cupric ion	0-10	prion like protein doppel	Homo sapiens	32-38
15218028-6	2004	Here we show by electron paramagnetic resonance and fluorescence spectroscopy that the in vitro binding of copper(II) to human recombinant Dpl occurs with a different pattern from that observed for recombinant PrP.	cupric ion	107-117	prion like protein doppel	Homo sapiens	139-142
15218028-7	2004	At physiological pH values, two copper(II)-binding sites with different affinities were found in Dpl.	cupric ion	32-42	prion like protein doppel	Homo sapiens	97-100
15218028-9	2004	As derived from the electron paramagnetic resonance characteristics, all Dpl-copper(II) complexes have a different coordination sphere from those present in PrP.	cupric ion	77-87	prion like protein doppel	Homo sapiens	73-76
12595265-7	2003	The helix alpha3 is shortened by more than two turns when compared with alpha3 of hPrP, which is enforced by the positioning of the second disulfide bond in hDpl.	Disulfides	139-148	prion like protein doppel	Homo sapiens	157-161
12547204-5	2003	The ease with which the hPrP structure can accommodate a variety of locations for a second disulfide bond within the presumed protein X-binding epitope suggests a functional role for the extensive perturbation by a natural second disulfide bond of the corresponding region in the human doppel protein.	Disulfides	91-100	prion like protein doppel	Homo sapiens	286-292
11063595-4	2000	Dpl 24-152 was shown to contain two disulfide bonds (Cys94-Cys145 and Cys108-Cys140).	Disulfides	36-45	prion like protein doppel	Homo sapiens	0-3
35220018-6	2022	Heparin-bile acid based conjugates, as ECM-mimicking component, were synthesized to selectively target the TEC marker doppel and doppel/VEGFR2 axis.	Heparin	0-7	prion like protein doppel	Homo sapiens	118-124
35220018-6	2022	Heparin-bile acid based conjugates, as ECM-mimicking component, were synthesized to selectively target the TEC marker doppel and doppel/VEGFR2 axis.	Heparin	0-7	prion like protein doppel	Homo sapiens	129-135
35220018-6	2022	Heparin-bile acid based conjugates, as ECM-mimicking component, were synthesized to selectively target the TEC marker doppel and doppel/VEGFR2 axis.	Bile Acids and Salts	8-17	prion like protein doppel	Homo sapiens	118-124
35220018-6	2022	Heparin-bile acid based conjugates, as ECM-mimicking component, were synthesized to selectively target the TEC marker doppel and doppel/VEGFR2 axis.	Bile Acids and Salts	8-17	prion like protein doppel	Homo sapiens	129-135
35220018-7	2022	The most effective compound LHbisD4 (low molecular weight heparin conjugated with 4 molecules of dimeric dexocholic acid) reduced tumor volume concentrated over doppel-expressing EC, and decreased tumor-interstitial VEGF without affecting its plasma concentration.	lhbisd4	28-35	prion like protein doppel	Homo sapiens	161-167
35220018-7	2022	The most effective compound LHbisD4 (low molecular weight heparin conjugated with 4 molecules of dimeric dexocholic acid) reduced tumor volume concentrated over doppel-expressing EC, and decreased tumor-interstitial VEGF without affecting its plasma concentration.	Heparin, Low-Molecular-Weight	37-65	prion like protein doppel	Homo sapiens	161-167
35220018-7	2022	The most effective compound LHbisD4 (low molecular weight heparin conjugated with 4 molecules of dimeric dexocholic acid) reduced tumor volume concentrated over doppel-expressing EC, and decreased tumor-interstitial VEGF without affecting its plasma concentration.	dexocholic acid	105-120	prion like protein doppel	Homo sapiens	161-167
35220018-8	2022	Doppel-destined LHbisD4 captured VEGF, formed an intermediate complex with doppel, VEGFR2, and VEGF but did not induce active VEGFR2 dimerization, and competitively inhibited HS for VEGF binding.	lhbisd4	16-23	prion like protein doppel	Homo sapiens	0-6
35220018-8	2022	Doppel-destined LHbisD4 captured VEGF, formed an intermediate complex with doppel, VEGFR2, and VEGF but did not induce active VEGFR2 dimerization, and competitively inhibited HS for VEGF binding.	lhbisd4	16-23	prion like protein doppel	Homo sapiens	75-81
3593706-6	1987	Polymerized DPL vesicles uniquely bound a protein of about 53 kDa which was not bound to other types of phosphatidylcholine liposomes.	Phosphatidylcholines	104-123	prion like protein doppel	Homo sapiens	12-15
3593706-9	1987	However, DPL nonpolymerized vesicles, while not causing aggregation, did impair ADP-induced aggregation of platelets.	Adenosine Diphosphate	80-83	prion like protein doppel	Homo sapiens	9-12
3593706-11	1987	Methacryloyl-based lipids of the DPL type seem to display interactions with the hemostatic process which militate against their in vivo utilization.	methacryloyl-based lipids	0-25	prion like protein doppel	Homo sapiens	33-36
180020-5	1976	Thermo-dynamic analysis of the ATP hydrolysis rates shows that DPL-enzyme has considerably larger values of activation enthalpy and activation entropy below the transition temperature (29 degrees) than those of the other preparations, while all enzyme preparations show similar free energies of activation.	Adenosine Triphosphate	31-34	prion like protein doppel	Homo sapiens	63-66
580813-4	1978	The inhibitory effect of albumin was potentiated by humidity; saturation of the atmosphere with water vapor at 37 degrees C abolished the DPL character of DPL-RSA mixtures and prevented its return (zero surface tension) upon reversal of the atmosphere from saturated water vapor to dry air.	Water	96-101	prion like protein doppel	Homo sapiens	138-141
580813-4	1978	The inhibitory effect of albumin was potentiated by humidity; saturation of the atmosphere with water vapor at 37 degrees C abolished the DPL character of DPL-RSA mixtures and prevented its return (zero surface tension) upon reversal of the atmosphere from saturated water vapor to dry air.	Water	96-101	prion like protein doppel	Homo sapiens	155-158
580813-4	1978	The inhibitory effect of albumin was potentiated by humidity; saturation of the atmosphere with water vapor at 37 degrees C abolished the DPL character of DPL-RSA mixtures and prevented its return (zero surface tension) upon reversal of the atmosphere from saturated water vapor to dry air.	rabbit sperm membrane autoantigen	159-162	prion like protein doppel	Homo sapiens	138-141
580813-4	1978	The inhibitory effect of albumin was potentiated by humidity; saturation of the atmosphere with water vapor at 37 degrees C abolished the DPL character of DPL-RSA mixtures and prevented its return (zero surface tension) upon reversal of the atmosphere from saturated water vapor to dry air.	rabbit sperm membrane autoantigen	159-162	prion like protein doppel	Homo sapiens	155-158
588607-4	1977	The significant changes of fluorescence intensity and maximum position of MBA and DMC were found in the regions of phase transitions at 23, 42, 54 and 31c in liposomes from DML, DPL, DSL and mixture of DML and DPL, respectively.	dmc	82-85	prion like protein doppel	Homo sapiens	178-181
588607-4	1977	The significant changes of fluorescence intensity and maximum position of MBA and DMC were found in the regions of phase transitions at 23, 42, 54 and 31c in liposomes from DML, DPL, DSL and mixture of DML and DPL, respectively.	dmc	82-85	prion like protein doppel	Homo sapiens	210-213
588607-5	1977	Cholesterol incorporation into liposomes from DPL led to a decrease of transition temperature and cooperativity for these liposomes.	Cholesterol	0-11	prion like protein doppel	Homo sapiens	46-49
8823-2	1976	At 37 degrees C DPL lowered surface tension to zero when spread from organic solvent or when absorbed from aqueous 0.15 M NaCl in the surface balance in which the surface film was exposed to the room air (dry film).	Sodium Chloride	122-126	prion like protein doppel	Homo sapiens	16-19
8823-3	1976	Upon saturation of the atmosphere with water vapor in equilibrium with the aqueous phase at 37 degrees C in a closed chamber, DPL lost the ability to produce zero surface tension, and the gamma min of the DPL film increased from zero to 22 dyne/cm.	Water	39-44	prion like protein doppel	Homo sapiens	126-129
8823-3	1976	Upon saturation of the atmosphere with water vapor in equilibrium with the aqueous phase at 37 degrees C in a closed chamber, DPL lost the ability to produce zero surface tension, and the gamma min of the DPL film increased from zero to 22 dyne/cm.	Water	39-44	prion like protein doppel	Homo sapiens	205-208
8823-4	1976	Addition of DPL in chloroform to distilled water before dispersion by sonication did not prevent the effect of the humidity.	Chloroform	19-29	prion like protein doppel	Homo sapiens	12-15
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Chloroform	18-28	prion like protein doppel	Homo sapiens	41-44
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Chloroform	18-28	prion like protein doppel	Homo sapiens	231-234
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Sodium Chloride	65-69	prion like protein doppel	Homo sapiens	41-44
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Chloroform	214-224	prion like protein doppel	Homo sapiens	41-44
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Water	266-271	prion like protein doppel	Homo sapiens	41-44
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Sodium Chloride	282-286	prion like protein doppel	Homo sapiens	41-44
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	cholesteryl palmitate	458-479	prion like protein doppel	Homo sapiens	41-44
6543323-15	1984	For both parameters, the order of increase is DML less than DPL = dipalmitoleoyllecithin (DPOL) less than DSL less than DAL less than DEL = dioleoyllecithin (DOL).	dipalmitoleoyllecithin	66-88	prion like protein doppel	Homo sapiens	60-63
6543323-17	1984	Cholesterol (48 mol%) restores protein-mediated transport activity to crystalline DPL bilayers and reduces the activity supported by fluid DPL bilayers.	Cholesterol	0-11	prion like protein doppel	Homo sapiens	82-85
6543323-17	1984	Cholesterol (48 mol%) restores protein-mediated transport activity to crystalline DPL bilayers and reduces the activity supported by fluid DPL bilayers.	Cholesterol	0-11	prion like protein doppel	Homo sapiens	139-142
6508435-5	1984	Histamine increased the frequency and the amplitude of phasic contractions in most strips from the antrum and the PPL; it increased the tonic contraction of a few DPL strips.	Histamine	0-9	prion like protein doppel	Homo sapiens	163-166
6508435-7	1984	Exposure to histamine produced no mechanical response in one fifth of the antral strips and in more than one third of the strips from both the PPL and the DPL.	Histamine	12-21	prion like protein doppel	Homo sapiens	155-158
6873198-2	1983	Liposomes were prepared from various conventional lipids and from a novel photopolymerizable phosphatidylcholine derivative (DPL, bis[1,2-(methacryloyloxy)dodecanoyl]-L-alpha-phosphatidylcholine).	Phosphatidylcholines	93-112	prion like protein doppel	Homo sapiens	125-128
180020-6	1976	The ESR data show that below their transition temperatures DPL-enzyme, and to a lesser degree del-enzyme, have a strongly restricted motion of their phospholipid molecules as compared with either DOL-enzyme or sarcoplasmic reticulum.	Phospholipids	149-161	prion like protein doppel	Homo sapiens	59-62
180020-8	1976	At 0 degrees, the rate of inorganic phosphate liberation is 8 times lower in DPL-enzyme than in del-enzyme with little difference in the steady state level of phosphoenzyme.	Phosphates	26-45	prion like protein doppel	Homo sapiens	77-80
180020-10	1976	Addition of ADP to the phosphorylated intermediate of DPL-enzyme induces a fast reversal of the phosphorylation reaction.	Adenosine Diphosphate	12-15	prion like protein doppel	Homo sapiens	54-57
34057364-2	2021	A series of pH-responsive random copolymers (DPL-DP60) comprising of a pH-responsive moiety 2-((leucinyl)oxy)ethyl methacrylate (l-Leu-HEMA) and hydrophobic methyl methacrylate (MMA) are synthesized and characterized.	copolymers	33-43	prion like protein doppel	Homo sapiens	45-48
32045197-3	2020	Here a fluorescent and gene loading capacity vector DPL, derived from diketopyrrolopyrrole (DPP) was developed for Bcl-2 siRNA targeted delivery and tumor imaging in vitro and in vivo.	Diketopyrrolopyrrole	70-90	prion like protein doppel	Homo sapiens	52-55
33039058-4	2020	The antioxidant potential of DpL was evaluated by estimating the total flavonoid and total phenolic content (TFC and TPC, respectively).	Flavonoids	71-80	prion like protein doppel	Homo sapiens	29-32
32045197-3	2020	Here a fluorescent and gene loading capacity vector DPL, derived from diketopyrrolopyrrole (DPP) was developed for Bcl-2 siRNA targeted delivery and tumor imaging in vitro and in vivo.	dpp	92-95	prion like protein doppel	Homo sapiens	52-55
27072903-1	2016	Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes.	Doxorubicin	139-150	prion like protein doppel	Homo sapiens	79-82
31621699-4	2019	Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA.	cinnamaldehyde	0-14	prion like protein doppel	Homo sapiens	177-180
31621699-4	2019	Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA.	cinnamaldehyde	0-14	prion like protein doppel	Homo sapiens	190-193
31621699-4	2019	Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA.	cinnamaldehyde	0-3	prion like protein doppel	Homo sapiens	177-180
31621699-4	2019	Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA.	cinnamaldehyde	0-3	prion like protein doppel	Homo sapiens	190-193
31621699-4	2019	Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA.	chlorin	25-32	prion like protein doppel	Homo sapiens	177-180
31621699-4	2019	Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA.	Glutathione	62-65	prion like protein doppel	Homo sapiens	177-180
31621699-6	2019	Once the OSA reached the tumor site, the high level of H2O2 triggered the degradation of DPL and led to the release of Cin and Ce6.	Water	55-59	prion like protein doppel	Homo sapiens	89-92
27072903-1	2016	Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes.	Vincristine	152-163	prion like protein doppel	Homo sapiens	79-82
27072903-1	2016	Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes.	Prednisolone	165-177	prion like protein doppel	Homo sapiens	79-82
27072903-1	2016	Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes.	asct	227-231	prion like protein doppel	Homo sapiens	79-82
27433588-1	2016	A series of pluronic grafted dendritic alpha,epsilon-poly(L-lysine)s (DPL-PF127) were synthesized by a conjugation reaction and evaluated the potential use of DPL-PF127 as a delivery agent of antisense oligonucleotide into A375 B3 cells.	-poly(l-lysine)	52-67	prion like protein doppel	Homo sapiens	70-73
27433588-3	2016	The number of pluronic F127 on DPL surface, determined by fluorescamine assay, increased proportionally to the mole ratio between DPL and activated PF127 in reaction.	Fluorescamine	58-71	prion like protein doppel	Homo sapiens	31-34
27433588-4	2016	DPL- PF127 showed the physical properties of decrease in zetapotential and increase in size as the mole ratio of PF127 to DPL increased.	pf127	5-10	prion like protein doppel	Homo sapiens	0-3
27433588-4	2016	DPL- PF127 showed the physical properties of decrease in zetapotential and increase in size as the mole ratio of PF127 to DPL increased.	pf127	5-10	prion like protein doppel	Homo sapiens	122-125
27433588-5	2016	The complex formation of DPL-PF127 with oligonucleotide was confirmed by running capillary zone electrophoresis (CZE) and agarose gel electrophoresis.	Oligonucleotides	40-55	prion like protein doppel	Homo sapiens	25-28
27433588-5	2016	The complex formation of DPL-PF127 with oligonucleotide was confirmed by running capillary zone electrophoresis (CZE) and agarose gel electrophoresis.	Sepharose	122-129	prion like protein doppel	Homo sapiens	25-28
27433588-6	2016	DPL-PF127, prepared at the mole ratio of 1:10 in reaction, was the most suitable as a delivery adjuvant of oligonucleotide.	Oligonucleotides	107-122	prion like protein doppel	Homo sapiens	0-3
27433588-7	2016	In addition, DPL-PF127/oligonucleotide complexes were taken into A375B3 cell without cellular toxicity and delivered antisense oligonucleotide into cell.	Oligonucleotides	23-38	prion like protein doppel	Homo sapiens	13-16
27433588-7	2016	In addition, DPL-PF127/oligonucleotide complexes were taken into A375B3 cell without cellular toxicity and delivered antisense oligonucleotide into cell.	Oligonucleotides	127-142	prion like protein doppel	Homo sapiens	13-16
25716226-12	2015	There was significantly less nitric oxide production in the PRPLP and PRPHP groups compared with controls (P < .05).	Nitric Oxide	29-41	prion like protein doppel	Homo sapiens	60-65
24671714-10	2015	At any time, %DPL was significantly (p < 0.05) higher in TC, TCF, and Novamin  compared with Fluoride.	Technetium	60-62	prion like protein doppel	Homo sapiens	14-17
24671714-10	2015	At any time, %DPL was significantly (p < 0.05) higher in TC, TCF, and Novamin  compared with Fluoride.	Fluorides	96-104	prion like protein doppel	Homo sapiens	14-17