PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31577975-5	2019	In this study, we aimed to explore the regulative effects of G-Rb3 on fatty acids oxidation and apoptosis by in vivo and in vitro studies.	Fatty Acids	70-81	stathmin-like 4	Mus musculus	63-66
33088689-6	2020	The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides.	protopanaxadiol	46-61	stathmin-like 4	Mus musculus	96-99
33088689-6	2020	The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides.	Ginsenosides	73-85	stathmin-like 4	Mus musculus	96-99
32294506-7	2020	Among them, Ginsenoside Rb3 (G-Rb3) had the best pharmacodynamics against OGD/R-induced loss of cell viability, and it was selected to verify the compound-target interaction.	ginsenoside Rb3	29-34	stathmin-like 4	Mus musculus	24-27
32294506-13	2020	Moreover, surface plasmon resonance (SPR) assays identified that G-Rb3 bound directly to RXRalpha with the affinity of KD = 10 x 10-5 M. CONCLUSION: By integrating network pharmacology and experimental validation, we identified that as the major active compound of DQP, G-Rb3 could ameliorate ROS-induced energetic metabolism dysfunction, maintain mitochondrial function and facilitate energy metabolism via directly targeting on RXRalpha.	Reactive Oxygen Species	293-296	stathmin-like 4	Mus musculus	67-70
31577975-8	2019	G-Rb3 treatment up-regulated expressions of key enzymes involved in beta-oxidation of fatty acids, including carnitine palmitoyltransterase-1alpha (CPT-1alpha), acyl-CoA dehydrogenase long chain (ACADL) and the major mitochondrial deacetylase enzyme sirtuin 3 (SIRT3).	Fatty Acids	86-97	stathmin-like 4	Mus musculus	2-5
31577975-10	2019	In vitro study demonstrated that G-Rb3 could protect mitochondrial membrane integrity and exert anti-apoptotic effects, in addition to regulating fatty acids oxidation.	Fatty Acids	146-157	stathmin-like 4	Mus musculus	35-38
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	Xylose	87-93	stathmin-like 4	Mus musculus	12-15
28970547-2	2017	In this study, for the first time, we assessed the non-toxic doses of the triterpene saponins (ginsenoside-Rb3 and ginsenoside-Rd) - as prebiotics - that effectively reinstated the dysbiotic-gut microbial composition and intestinal microenvironment in an ApcMin/+ mice model.	triterpene saponins	74-93	stathmin-like 4	Mus musculus	107-110
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	Glucose	100-107	stathmin-like 4	Mus musculus	12-15
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	protopanaxadiol	122-143	stathmin-like 4	Mus musculus	12-15
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	protopanaxadiol	145-148	stathmin-like 4	Mus musculus	12-15
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	CHEBI:166892	157-165	stathmin-like 4	Mus musculus	12-15
20969942-0	2011	Inactivation of GABA(A) receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen-glucose deprivation.	oxygen-glucose	107-121	stathmin-like 4	Mus musculus	53-56
25084093-5	2014	Our data demonstrate that ginsenoside Rb3 suppresses OGD-Rep-induced cell apoptosis by the suppression of ROS generation.	ros	106-109	stathmin-like 4	Mus musculus	38-41
21948936-2	2012	We report a major active ingredient of total ginsenosides, the ginsenoside Rb3 (Rb3), which may have antidepressant-like effects.	Ginsenosides	45-57	stathmin-like 4	Mus musculus	75-78
21948936-2	2012	We report a major active ingredient of total ginsenosides, the ginsenoside Rb3 (Rb3), which may have antidepressant-like effects.	Ginsenosides	45-57	stathmin-like 4	Mus musculus	80-83
21948936-4	2012	In a reserpine-induced syndrome model, Rb3 attenuated hypothermia, palpebral ptosis, and akinesia.	Reserpine	5-14	stathmin-like 4	Mus musculus	39-42
21948936-5	2012	In the chronic mild stress model, chronic Rb3 administration reversed the decrease in locomotor activity, novelty-suppressed feeding, and sucrose preference.	Sucrose	138-145	stathmin-like 4	Mus musculus	42-45
21948936-7	2012	Finally, we found, using whole-cell patch-clamp recordings, that the action potential transmission in neurons within the somatosensory cortex was excited by Rb3 perfusion and blocked with Panax notoginseng total saponins extracted from leaves.	Saponins	212-220	stathmin-like 4	Mus musculus	157-160
3585331-1	1987	The turnover rates and steady-state levels of gamma-aminobutyric acid (GABA) have been determined in 15 brain areas of three sublines of inbred mice differing in their susceptibility to audiogenic seizures: Rb3, which is seizure resistant; Rb2, which develops clonic seizures; and Rb1, which develops tonic-clonic seizures.	gamma-Aminobutyric Acid	71-75	stathmin-like 4	Mus musculus	207-210
16571898-4	2006	The two major reaction products of cisplatin, the guanine-guanine (Pt-[GG]) and adenine-guanine (Pt-[AG]) intrastrand crosslinks are recognized by Mab R-C18 and R-B3, respectively.	Cisplatin	35-44	stathmin-like 4	Mus musculus	161-165
16571898-4	2006	The two major reaction products of cisplatin, the guanine-guanine (Pt-[GG]) and adenine-guanine (Pt-[AG]) intrastrand crosslinks are recognized by Mab R-C18 and R-B3, respectively.	guanine-guanine	50-65	stathmin-like 4	Mus musculus	161-165
16571898-4	2006	The two major reaction products of cisplatin, the guanine-guanine (Pt-[GG]) and adenine-guanine (Pt-[AG]) intrastrand crosslinks are recognized by Mab R-C18 and R-B3, respectively.	Platinum	67-69	stathmin-like 4	Mus musculus	161-165
16571898-4	2006	The two major reaction products of cisplatin, the guanine-guanine (Pt-[GG]) and adenine-guanine (Pt-[AG]) intrastrand crosslinks are recognized by Mab R-C18 and R-B3, respectively.	adenine guanine	80-95	stathmin-like 4	Mus musculus	161-165
16571898-4	2006	The two major reaction products of cisplatin, the guanine-guanine (Pt-[GG]) and adenine-guanine (Pt-[AG]) intrastrand crosslinks are recognized by Mab R-C18 and R-B3, respectively.	Platinum	97-99	stathmin-like 4	Mus musculus	161-165
1975652-8	1990	Common lower levels (approximately -20%: Rb1/Rb3, Rb2/Rb3) of Gln in Temporal Cortex may be implicated in seizure susceptibility.	Glutamine	62-65	stathmin-like 4	Mus musculus	45-48
1975652-8	1990	Common lower levels (approximately -20%: Rb1/Rb3, Rb2/Rb3) of Gln in Temporal Cortex may be implicated in seizure susceptibility.	Glutamine	62-65	stathmin-like 4	Mus musculus	54-57
3585331-2	1987	In the Rb1 subline, GABA steady-state levels are lower than in the Rb3 subline in three of the 15 areas examined (cerebellum, anterior colliculus, and amygdala), whereas in the Rb2 subline, steady-state levels are either higher (posterior colliculus and hippocampus) or lower (amygdala) than in the Rb3 subline.	gamma-Aminobutyric Acid	20-24	stathmin-like 4	Mus musculus	299-302