PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
7873524-1	1995	Vancomycin resistance in Enterococcus faecium requires five genes: vanR, vanS, vanH, vanA, and vanX.	Vancomycin	0-10	VanH protein	Enterococcus faecium	79-83
9605319-1	1998	The gene encoding the vancomycin resistance protein VanH from Enterococcus faecium, a D-lactate dehydrogenase, has been cloned into a thioredoxin expression system (pTRxFus) and expressed as a fusion protein.	Vancomycin	22-32	VanH protein	Enterococcus faecium	52-56
9605319-6	1998	Based on k(cat)/KM for pyruvate, it is 20% as active as native VanH.	Pyruvic Acid	23-31	VanH protein	Enterococcus faecium	63-67
9605319-7	1998	Michaelis constants for NADPH, NADH, and pyruvate, of approximately 3.5 microM, 19.0 microM, and 1.5 mM, respectively, were comparable to those reported for the native VanH (Bugg TDH et al., 1991, Biochemistry 30:10408-10415).	NADP	24-29	VanH protein	Enterococcus faecium	168-172
9605319-7	1998	Michaelis constants for NADPH, NADH, and pyruvate, of approximately 3.5 microM, 19.0 microM, and 1.5 mM, respectively, were comparable to those reported for the native VanH (Bugg TDH et al., 1991, Biochemistry 30:10408-10415).	NAD	31-35	VanH protein	Enterococcus faecium	168-172
9605319-7	1998	Michaelis constants for NADPH, NADH, and pyruvate, of approximately 3.5 microM, 19.0 microM, and 1.5 mM, respectively, were comparable to those reported for the native VanH (Bugg TDH et al., 1991, Biochemistry 30:10408-10415).	Pyruvic Acid	41-49	VanH protein	Enterococcus faecium	168-172
9605319-8	1998	Like native VanH, maximum activity of the fusion protein requires the presence of an anion (phosphate or acetate), however, in addition, a strongly reducing environment is needed for optimal efficacy.	Phosphates	92-101	VanH protein	Enterococcus faecium	12-16
9605319-8	1998	Like native VanH, maximum activity of the fusion protein requires the presence of an anion (phosphate or acetate), however, in addition, a strongly reducing environment is needed for optimal efficacy.	Acetates	105-112	VanH protein	Enterococcus faecium	12-16
7873524-2	1995	The functions and mechanism of four gene products have been known, with VanR/S for signal transduction and transcriptional regulation and VanH/A to synthesize D-Ala-D-lactate.	d-ala-d-lactate	159-174	VanH protein	Enterococcus faecium	138-142
1931965-0	1991	Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.	Vancomycin	20-30	VanH protein	Enterococcus faecium	163-167
1931965-0	1991	Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.	Vancomycin	132-142	VanH protein	Enterococcus faecium	163-167
1931965-4	1991	VanA was found to catalyze ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate (Km = 0.60 mM).	Esters	27-32	VanH protein	Enterococcus faecium	101-105
1931965-4	1991	VanA was found to catalyze ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate (Km = 0.60 mM).	dalbergioidin	56-65	VanH protein	Enterococcus faecium	101-105
1931965-4	1991	VanA was found to catalyze ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate (Km = 0.60 mM).	d-hydroxy acid	74-88	VanH protein	Enterococcus faecium	101-105
1931965-4	1991	VanA was found to catalyze ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate (Km = 0.60 mM).	D-2-hydroxybutyrate	132-151	VanH protein	Enterococcus faecium	101-105
35495706-10	2022	Further in silico analyses revealed that an IS1216E-based composite transposon was generated in SC1762-D, and it disrupted the vanH gene, likely affecting the structure and expression of the vanA gene cluster and resulting in resensitization to glycopeptides.	Glycopeptides	245-258	VanH protein	Enterococcus faecium	127-131
11376048-2	2001	The vancomycin resistance genes were amplified by the long vanB PCR, which amplifies the 6,373-bp vanB gene cluster including the vanR(B2), vanS(B2), vanY(B2), vanW(B2), vanH(B2), vanB2, and vanX(B2) genes.	Vancomycin	4-14	VanH protein	Enterococcus faecium	170-177