PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12382055-0	2002	MoeA, an enzyme in the molybdopterin synthesis pathway, is required for rifamycin SV production in Amycolatopsis mediterranei U32.	rifamycin SV	72-84	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	0-4
12382055-4	2002	The structural gene moeA, which is involved in molybdopterin synthesis in various organisms, has been cloned from rifamycin SV-producing Amycolatopsis mediterranei strain U32.	rifamycin SV	114-123	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	20-24
12382055-7	2002	To further investigate the possible physiological function of the moeA gene, a double crossover gene replacement was achieved by inserting an aparmycin resistance gene into moeA in the A. mediterranei U32 chromosome.	aparmycin	142-151	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	66-70
12382055-8	2002	Phenotype analysis showed that the moeA gene is required for A. mediterranei growth in a minimal medium with nitrate as sole nitrogen source, possibly because nitrate reductase activity is diminished due to disruption of the moeA gene.	Nitrates	109-116	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	35-39
12382055-8	2002	Phenotype analysis showed that the moeA gene is required for A. mediterranei growth in a minimal medium with nitrate as sole nitrogen source, possibly because nitrate reductase activity is diminished due to disruption of the moeA gene.	Nitrogen	125-133	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	35-39
12382055-9	2002	Compared to the wild type strain, moeA-disrupted mutants lost 95% of their rifamycin SV production capacity in complex fermentation media.	rifamycin SV	75-87	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	34-38
12382055-10	2002	The results demonstrate that the moeA gene is necessary for rifamycin SV production in A. mediterranei, and that the nitrogen assimilation pathway involved in nitrate reductase is the major pathway for the genesis of the amide nitrogen atom in the rifamycin SV molecule.	rifamycin SV	60-72	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	33-37
12382055-10	2002	The results demonstrate that the moeA gene is necessary for rifamycin SV production in A. mediterranei, and that the nitrogen assimilation pathway involved in nitrate reductase is the major pathway for the genesis of the amide nitrogen atom in the rifamycin SV molecule.	Amides	221-226	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	33-37
12382055-10	2002	The results demonstrate that the moeA gene is necessary for rifamycin SV production in A. mediterranei, and that the nitrogen assimilation pathway involved in nitrate reductase is the major pathway for the genesis of the amide nitrogen atom in the rifamycin SV molecule.	Nitrogen	227-235	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	33-37
12382055-10	2002	The results demonstrate that the moeA gene is necessary for rifamycin SV production in A. mediterranei, and that the nitrogen assimilation pathway involved in nitrate reductase is the major pathway for the genesis of the amide nitrogen atom in the rifamycin SV molecule.	rifamycin SV	248-260	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	33-37