PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20610720-2	2010	Virus egress from cells depended on open reading frame 3 (ORF3) protein, and a proline-rich sequence in ORF3 was important for egress from cultured cells and for infection of macaques.	Proline	79-86	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	104-108
25203800-3	2014	The recombinant plasmid was then transfected into BHK-21 cells via the Lipofectamine 2000 reagent; the subsequent ORF3 gene overexpression was confirmed by RT-PCR and the protein expression and location was detected by Western blotting and immunofluorescence assay.Results TThe pDsRed-Monomer-N1-ORF3 recombinant plasmid was successfully constructed.	Lipofectamine	71-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	114-118
21796436-7	2011	Moreover, the relative positions and length of functional domains corresponding to movement protein (MP), coat protein (CP), aspartate protease (PR) and reverse transcriptase/ribonuclease H (RT/RNase H) of ORF3 of Chinsura isolate were completely identical with SA isolates.	sa	262-264	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	206-210
22167881-0	2011	Facile access to the pnictocenium ions [Cp*ECl]+ (E = P, As) and [(Cp*)2P]+: chloride ion affinity of Al(OR(F))3.	pnictocenium	21-33	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	102-112
22167881-0	2011	Facile access to the pnictocenium ions [Cp*ECl]+ (E = P, As) and [(Cp*)2P]+: chloride ion affinity of Al(OR(F))3.	Chlorides	77-85	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	102-112
24435914-1	2014	Upon reaction of gaseous Me3SiF with the in situ prepared Lewis acid Al(OR(F))3, the stable ion-like silylium compound Me3 Si-F-Al(OR(F))3 1 forms.	FLUOROTRIMETHYLSILANE	25-31	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	69-79
24435914-1	2014	Upon reaction of gaseous Me3SiF with the in situ prepared Lewis acid Al(OR(F))3, the stable ion-like silylium compound Me3 Si-F-Al(OR(F))3 1 forms.	FLUOROTRIMETHYLSILANE	25-31	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	128-138
24435914-1	2014	Upon reaction of gaseous Me3SiF with the in situ prepared Lewis acid Al(OR(F))3, the stable ion-like silylium compound Me3 Si-F-Al(OR(F))3 1 forms.	silylium	101-109	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	69-79
24435914-1	2014	Upon reaction of gaseous Me3SiF with the in situ prepared Lewis acid Al(OR(F))3, the stable ion-like silylium compound Me3 Si-F-Al(OR(F))3 1 forms.	silylium	101-109	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	128-138
24435914-1	2014	Upon reaction of gaseous Me3SiF with the in situ prepared Lewis acid Al(OR(F))3, the stable ion-like silylium compound Me3 Si-F-Al(OR(F))3 1 forms.	RUTHENIUM-PYRIDOCARBAZOLE-3	25-28	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	69-79
24435914-1	2014	Upon reaction of gaseous Me3SiF with the in situ prepared Lewis acid Al(OR(F))3, the stable ion-like silylium compound Me3 Si-F-Al(OR(F))3 1 forms.	RUTHENIUM-PYRIDOCARBAZOLE-3	25-28	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	128-138
24435914-3	2014	Thus, in reactions of 1 with soft nucleophiles (Nu), such as phosphanes, the silylium side interacts in an orbital-controlled manner, with formation of [Me3Si-Nu](+) and the weakly coordinating [F-Al(OR(F))3](-) or [((F)RO)3Al-F-Al(OR(F))3](-) anions.	phosphine	61-71	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	197-207
24435914-3	2014	Thus, in reactions of 1 with soft nucleophiles (Nu), such as phosphanes, the silylium side interacts in an orbital-controlled manner, with formation of [Me3Si-Nu](+) and the weakly coordinating [F-Al(OR(F))3](-) or [((F)RO)3Al-F-Al(OR(F))3](-) anions.	phosphine	61-71	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	229-239
24435914-3	2014	Thus, in reactions of 1 with soft nucleophiles (Nu), such as phosphanes, the silylium side interacts in an orbital-controlled manner, with formation of [Me3Si-Nu](+) and the weakly coordinating [F-Al(OR(F))3](-) or [((F)RO)3Al-F-Al(OR(F))3](-) anions.	silylium	77-85	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	197-207
24435914-3	2014	Thus, in reactions of 1 with soft nucleophiles (Nu), such as phosphanes, the silylium side interacts in an orbital-controlled manner, with formation of [Me3Si-Nu](+) and the weakly coordinating [F-Al(OR(F))3](-) or [((F)RO)3Al-F-Al(OR(F))3](-) anions.	silylium	77-85	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	229-239
24435914-4	2014	If exchanged for hard nucleophiles, such as primary alcohols, the aluminum side reacts in a charge-controlled manner, with release of FSiMe3 gas and formation of the adduct R(H)O-Al(OR(F))3.	Alcohols	52-60	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	179-189
24435914-4	2014	If exchanged for hard nucleophiles, such as primary alcohols, the aluminum side reacts in a charge-controlled manner, with release of FSiMe3 gas and formation of the adduct R(H)O-Al(OR(F))3.	Aluminum	66-74	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	179-189
23775757-7	2013	Furthermore, alternate trans-splicing was identified in the ORF3" mRNA between orientation diverse transcripts with typical GT-AG donor/acceptor junctions.	gt-ag	124-129	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-64
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Serine	159-162	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	4-8
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Serine	159-162	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	209-213
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Alanine	164-167	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	4-8
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Alanine	164-167	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	209-213
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Proline	154-157	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	4-8
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Proline	154-157	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	209-213
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	psap	178-182	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	4-8
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	psap	178-182	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	209-213
17901199-8	2008	By contrast, RGS2 products initiating from methionines at positions 16 (ORF3) and 33 (ORF4) were impaired as inhibitors of type V adenylyl cyclase (ACV) compared with full-length RGS2.	Methionine	43-54	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	72-76
20179852-0	2010	Preparation, structure and analysis of the bonding in the molecular entity (OSO)2Li{[AlF(ORF)3]Li[Al(ORF)4]} (RF = C(CF3)3).	(oso)2li	75-83	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	89-94
18211098-7	2008	One of the ORF3-interacting partners thus isolated and identified was hemopexin, a 60 kDa acute-phase plasma glycoprotein with a high binding affinity to heme.	Heme	154-158	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	11-15
15105550-4	2004	Arginine-to-asparagine substitutions in this region decreased the level of the ORF3 protein accumulation in nuclei.	Arginine	0-8	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	79-83
17488721-8	2007	Surprisingly, Orf3-expressing cells were protected against staurosporine-induced cell death by preservation of mitochondrial potential and membrane integrity.	Staurosporine	59-72	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-18
17488721-9	2007	A small interfering RNA-mediated reduction in Orf3 and VDAC levels also made cells sensitive to staurosporine.	Staurosporine	96-109	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	46-50
15382941-2	2004	The molecular structure of gallium schizokinen, GaSz, was determined by combined (1)H NMR, Hartree-Fock ab initio calculations, DFT, and empirical modeling of vicinal proton NMR spin-spin couplings.	gallium schizokinen	27-46	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	48-52
15382941-3	2004	The metal-coordination geometry of GaSz was determined from NOE contacts to be cis-cis with respect to the two chelating hydroxamates.	Metals	4-9	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	35-39
15382941-13	2004	The ab initio modeling of gallium acinetoferrin, GaAf, and analogues derived from the structure of GaSz has shown that the pendant trans-octenoyl fragments are oriented in opposite directions with the average planar angle of ca.	gallium acinetoferrin	26-47	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	99-103
32287548-2	2005	Our studies suggest that the function of ORF3 could be involved in FAD/NAD binding according to its predicted structure and comparison with other structure neighbors.	Flavin-Adenine Dinucleotide	67-70	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	41-45
32287548-3	2005	Furthermore, we identified three pairs of non-canonical N-H pi interactions in the structure of ORF3, which can make contributions to the stability of protein structure.	Nitrogen	56-57	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	96-100
15105550-4	2004	Arginine-to-asparagine substitutions in this region decreased the level of the ORF3 protein accumulation in nuclei.	Asparagine	12-22	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	79-83
12124457-5	2002	The full-length nucleotide sequence of HE-JI4 consisted of 7171 nucleotides excluding the poly(A) tail and contained ORF1 encoding 1684 amino acids, ORF2 encoding 671 amino acids and ORF3 encoding 114 amino acids.	Helium	39-41	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	183-187
12029156-8	2002	A heptad motif, VSRRIYQ, which is present in a single copy in ORF2 and 3 proteins, was identified; this arrangement is completely conserved in all European-type PRRSV sequences available.	vsrriyq	16-23	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	62-72
34777295-9	2021	Allicin further reduced the abundance of the structural viral proteins N, M, S and ORF3 in the host-virus proteome.	allicin	0-7	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	83-87
11601910-5	2001	Umbraviral ORF3 proteins contain a conserved arginine-rich domain, and the possible roles of this motif in the functions of the proteins are discussed.	Arginine	45-53	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	11-15
11062050-7	2000	Direct N- and C-terminal sequence analysis of the purified ORF3 protein obtained by expression in bacteria demonstrated the presence of intact, uncleaved termini, suggesting that the observed difference between the calculated and the apparent masses in SDS-PAGE was not due to proteolytic processing of the protein.	Sodium Dodecyl Sulfate	253-256	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	59-63
7685415-6	1993	When the mutant ORF3 included an additional frameshift mutation which extended the ORF beyond the initiation site for the gag, gag-pol, and env proteins, host cells were initially transformed but died soon thereafter.	Glycosaminoglycans	122-125	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	16-20
10466823-7	1999	The cysteine-rich region of ORF3 showed the greatest variation.	Cysteine	4-12	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	28-32
10235465-7	1999	ORF 3 shows nests of CG dinucleotides and CGG trinucleotides, which are reminiscent of CGG nests predisposing subjects to anticipation of certain human diseases involving tumor generation.	trinucleotides	46-60	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	0-5
34721997-12	2021	Besides, N- and O-glycosylation analysis of S, N, and ORF3 protein reveals three known sites (25G+, 123N+, and 62V+) and three novel sites (144D+, 1009M+, and 1279L+) in the IBT/VN/2018 strain compared with the vaccine strains.	Nitrogen	9-10	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	54-58
34699255-9	2021	Our findings first preliminarily found that ORF3 protein may affect triglyceride activation (GO:0006642) and riboflavin metabolism (ko00740) in HepG2 cells, which provides a scientific basis for further elucidating the effect of ORF3 on host lipid metabolism and the mechanism of SHEV infection.	Triglycerides	68-80	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	44-48
34699255-9	2021	Our findings first preliminarily found that ORF3 protein may affect triglyceride activation (GO:0006642) and riboflavin metabolism (ko00740) in HepG2 cells, which provides a scientific basis for further elucidating the effect of ORF3 on host lipid metabolism and the mechanism of SHEV infection.	Triglycerides	68-80	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	229-233
34699255-9	2021	Our findings first preliminarily found that ORF3 protein may affect triglyceride activation (GO:0006642) and riboflavin metabolism (ko00740) in HepG2 cells, which provides a scientific basis for further elucidating the effect of ORF3 on host lipid metabolism and the mechanism of SHEV infection.	Riboflavin	109-119	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	44-48
34699255-9	2021	Our findings first preliminarily found that ORF3 protein may affect triglyceride activation (GO:0006642) and riboflavin metabolism (ko00740) in HepG2 cells, which provides a scientific basis for further elucidating the effect of ORF3 on host lipid metabolism and the mechanism of SHEV infection.	Riboflavin	109-119	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	229-233
33406573-7	2021	Genes orf5, pksCT, orf3, orf1, orf6, and ctnE were significantly downregulated, demonstrating that genistein addition indeed affects citrinin synthesis.	Genistein	99-108	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	19-23
35487365-5	2022	Animal inoculation indicated that both rJS-ORF2-4-CON and rJS-ORF5-6-CON did not cause obvious clinical signs in piglets and could induce heterologous nAbs after immunization.	nabs	151-155	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	43-49
3041026-8	1987	The amino acid sequence of the presumptive polypeptide encoded by ORF3, a 33.6-kDa molecule, exhibited an unusual, clustered 16-fold repeat of the dipeptide arginine-serine in a protein that showed an overall preponderance of basic amino acids.	dipeptide arginine-serine	147-172	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	66-70
3041026-8	1987	The amino acid sequence of the presumptive polypeptide encoded by ORF3, a 33.6-kDa molecule, exhibited an unusual, clustered 16-fold repeat of the dipeptide arginine-serine in a protein that showed an overall preponderance of basic amino acids.	Amino Acids, Basic	226-243	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	66-70
33996960-6	2021	In HepG2 cells, we identified 62 significantly differentially expressed genes (DEGs) (6,564 transcripts) and 319 lncRNAs (124 known lncRNAs and 195 novel lncRNAs) that were affected by ORF3, which were involved in systemic lupus erythematosus, Staphylococcus aureus infection, signaling pathways pluripotency regulation of stem cells, the peroxisome proliferator-activated receptor (PPAR) signaling pathway, and platinum drug resistance pathways.	Platinum	412-420	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	185-189
33996960-8	2021	Our results revealed that the lncRNA profile in host cells affected by ORF3, swine HEV ORF3, might affect the pentose and glucuronate interconversions and mediate the formation of obstructive jaundice by influencing bile secretion, which will help to determine the function of ORF3 and the infection mechanism and treatment of swine HE.	Glucuronic Acid	122-133	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	87-91
33996960-8	2021	Our results revealed that the lncRNA profile in host cells affected by ORF3, swine HEV ORF3, might affect the pentose and glucuronate interconversions and mediate the formation of obstructive jaundice by influencing bile secretion, which will help to determine the function of ORF3 and the infection mechanism and treatment of swine HE.	Pentoses	110-117	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	71-75
33996960-8	2021	Our results revealed that the lncRNA profile in host cells affected by ORF3, swine HEV ORF3, might affect the pentose and glucuronate interconversions and mediate the formation of obstructive jaundice by influencing bile secretion, which will help to determine the function of ORF3 and the infection mechanism and treatment of swine HE.	Pentoses	110-117	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	87-91
33996960-8	2021	Our results revealed that the lncRNA profile in host cells affected by ORF3, swine HEV ORF3, might affect the pentose and glucuronate interconversions and mediate the formation of obstructive jaundice by influencing bile secretion, which will help to determine the function of ORF3 and the infection mechanism and treatment of swine HE.	Pentoses	110-117	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	87-91
33996960-8	2021	Our results revealed that the lncRNA profile in host cells affected by ORF3, swine HEV ORF3, might affect the pentose and glucuronate interconversions and mediate the formation of obstructive jaundice by influencing bile secretion, which will help to determine the function of ORF3 and the infection mechanism and treatment of swine HE.	Glucuronic Acid	122-133	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	71-75
33996960-8	2021	Our results revealed that the lncRNA profile in host cells affected by ORF3, swine HEV ORF3, might affect the pentose and glucuronate interconversions and mediate the formation of obstructive jaundice by influencing bile secretion, which will help to determine the function of ORF3 and the infection mechanism and treatment of swine HE.	Glucuronic Acid	122-133	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	87-91
31753030-10	2019	Analysis of the amino acid sequence of ORF3 indicated two hydrophobic domains (HD) and single conserved proline-rich domain (PRD) PREPSAPP (PXXPXXPP) with a single PSAP motif found in C-terminal.	Proline	104-111	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	39-43
32423021-5	2020	When overexpressed, ORF3 could suppress Poly I:C mediated type I IFN production and induction.	Poly I	40-46	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	20-24
31287589-4	2019	Thus, reaction of the silver salt in the presence of the ligand with Fp-Br yielded [Fp-P4 S3 ][Al(ORF )4 ] (1 a), [Fp-P4 S3 ][F(Al(ORF )3 )2 ] (1 b), and [Fp-P4 Se3 ][Al(ORF )4 ] (2).	Sodium 2-anthraquinonesulfonate	22-33	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	131-137
31383304-7	2019	In contrast, conversion of LC3-I/LC3-II could be significantly inhibited by 4-PBA, an ER stress inhibitor, indicating that ORF3-induced autophagy is dependent on ER stress response.	4-phenylbutylamine	76-81	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	123-127
30532200-6	2018	Abrogation of palmitoylation by site-directed mutagenesis or 2-BP treatment altered the subcellular localization of ORF3 protein, reduced the stability of the protein and strongly impaired the secretion of infectious particles.	2-bromopalmitate	61-65	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	116-120
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine	137-147	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-23
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	4-phenylbutyric acid	190-206	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-23
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	4-phenylbutyric acid	208-213	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-23
30651358-11	2019	We propose that PCV2-driven ER stress is Cap dependent and could lead to mitochondrial apoptotic responses independent of ORF3 via perturbation of intracellular Ca2+ homeostasis and accumulation of ROS.IMPORTANCE PCV2 encodes protein ORF3, a putative protein with proapoptotic activity.	Reactive Oxygen Species	198-201	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	234-238
30651358-13	2019	Here we clearly show that PCV2 infection or Cap expression induces ORF3-independent apoptosis via increased cytosolic and mitochondrial Ca2+ levels and cellular ROS levels as a result of activation of the PERK pathway.	Reactive Oxygen Species	161-164	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	67-71
30808699-3	2019	Previously, we showed that E4-ORF3 functions as a SUMO E3 ligase of transcriptional intermediary factor-1 gamma (TIF-1gamma) and promotes poly-SUMO chain formation.	sumo	50-54	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	30-34
30394591-4	2019	This contribution discusses the coordination chemistry, steric and electronic properties of PIII ligands bearing highly fluorinated alkoxide groups of the general form PRn (ORF )3-n , where R=Ph, RF =C(H)(CF3 )2 and C(CF3 )3 ; n=1-3.	alkoxide	132-140	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	155-179
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	2-BUTYNE	26-34	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	2-BUTYNE	26-34	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	me3si-f-al	49-59	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	me3si-f-al	49-59	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	Salts	85-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	Salts	85-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	cyclobutenyl	119-131	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	cyclobutenyl	119-131	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	me4c4	140-145	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	me4c4	140-145	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	sime3	146-151	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	sime3	146-151	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	al-f-al	154-161	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	al-f-al	154-161	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	al-f-al	168-175	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	60-65
30997003-2	2019	Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR).	al-f-al	168-175	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	195-200
30997003-7	2019	By the addition of Et2O to a solution of 1, the [F-Al(ORF)3]- anion (and Et2O-Al(ORF)3) was generated from the [al-f-al]- counterion.	Ether	19-23	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	54-59
30997003-7	2019	By the addition of Et2O to a solution of 1, the [F-Al(ORF)3]- anion (and Et2O-Al(ORF)3) was generated from the [al-f-al]- counterion.	Ether	19-23	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	73-86
30997003-7	2019	By the addition of Et2O to a solution of 1, the [F-Al(ORF)3]- anion (and Et2O-Al(ORF)3) was generated from the [al-f-al]- counterion.	al-f-al	112-119	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	54-59
30997003-7	2019	By the addition of Et2O to a solution of 1, the [F-Al(ORF)3]- anion (and Et2O-Al(ORF)3) was generated from the [al-f-al]- counterion.	al-f-al	112-119	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	73-86
30997003-8	2019	Subsequently, the [F-Al(ORF)3]- anion abstracted the [Me3Si]+ moiety from [Me4C4-SiMe3]+, probably releasing CBD.	me3si	54-59	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	24-29
30997003-8	2019	Subsequently, the [F-Al(ORF)3]- anion abstracted the [Me3Si]+ moiety from [Me4C4-SiMe3]+, probably releasing CBD.	me4c4-sime3	75-86	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	24-29
30997003-8	2019	Subsequently, the [F-Al(ORF)3]- anion abstracted the [Me3Si]+ moiety from [Me4C4-SiMe3]+, probably releasing CBD.	Cannabidiol	109-112	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	24-29
29656087-9	2018	A cysteine signature at position 81 in ORF3 was observed in the boars.	Cysteine	2-10	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	39-43
30068652-7	2018	Using a molecular dynamic simulation, we observed that both gag-PTAP and ORF3-PSAP motifs bind to the same site in UEV-TSG101 by hydrogen bonding.	Hydrogen	129-137	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	73-77
30310626-1	2018	By reaction of the Lewis acid Me3Si-F-Al(ORF)3 with a series of [PF6]- salts, gaseous PF5 and Me3Si-F are liberated and salts of the anion [F-Al(ORF)3]- ([f-al]-; RF = C(CF3)3) can be obtained.	PHOSPHORUS PENTAFLUORIDE	86-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	30-46
30310626-1	2018	By reaction of the Lewis acid Me3Si-F-Al(ORF)3 with a series of [PF6]- salts, gaseous PF5 and Me3Si-F are liberated and salts of the anion [F-Al(ORF)3]- ([f-al]-; RF = C(CF3)3) can be obtained.	PHOSPHORUS PENTAFLUORIDE	86-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	41-46
30310626-1	2018	By reaction of the Lewis acid Me3Si-F-Al(ORF)3 with a series of [PF6]- salts, gaseous PF5 and Me3Si-F are liberated and salts of the anion [F-Al(ORF)3]- ([f-al]-; RF = C(CF3)3) can be obtained.	me3si-f	30-37	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	41-46
30310626-2	2018	By addition of another equivalent of Me3Si-F-Al(ORF)3 to [f-al]-, gaseous Me3Si-F is released and salts of the least coordinating anion [(RFO)3Al-F-Al(ORF)3]- ([al-f-al]-) are formed.	f-al	58-62	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	37-53
30310626-2	2018	By addition of another equivalent of Me3Si-F-Al(ORF)3 to [f-al]-, gaseous Me3Si-F is released and salts of the least coordinating anion [(RFO)3Al-F-Al(ORF)3]- ([al-f-al]-) are formed.	f-al	58-62	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	48-53
30310626-2	2018	By addition of another equivalent of Me3Si-F-Al(ORF)3 to [f-al]-, gaseous Me3Si-F is released and salts of the least coordinating anion [(RFO)3Al-F-Al(ORF)3]- ([al-f-al]-) are formed.	me3si-f	37-44	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	48-53
30310626-2	2018	By addition of another equivalent of Me3Si-F-Al(ORF)3 to [f-al]-, gaseous Me3Si-F is released and salts of the least coordinating anion [(RFO)3Al-F-Al(ORF)3]- ([al-f-al]-) are formed.	Aluminum	28-30	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	37-53
30310626-2	2018	By addition of another equivalent of Me3Si-F-Al(ORF)3 to [f-al]-, gaseous Me3Si-F is released and salts of the least coordinating anion [(RFO)3Al-F-Al(ORF)3]- ([al-f-al]-) are formed.	Aluminum	28-30	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	48-53
30310626-8	2018	Thus, it is similarly Lewis acidic as BF3 and eventually reacts with nucleophiles (Nu) from the reaction environment to yield Nu-Al(ORF)3 and [f-al]-.	nu-al	126-131	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	132-137
30310626-11	2018	Subsequently it may be transformed into the [al-f-al]- salt by simple addition of one equivalent of Me3Si-F-Al(ORF)3.	al-f-al]- salt	45-59	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	111-116
30310626-11	2018	Subsequently it may be transformed into the [al-f-al]- salt by simple addition of one equivalent of Me3Si-F-Al(ORF)3.	me3si-f-al	100-110	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	111-116
29471051-8	2018	ORF3 mutants with proline-to-leucine mutations at amino acids (aa) 93, 96 and/or 98 in ORF3 were constructed and transfected into PLC/PRF/5 cells.	Proline	18-25	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	0-4
29529178-2	2018	In this work, two multidrug efflux pumps, Orf14 and Orf3, were modulated in the epothilone production strain Burkholderia DSM7029::Tn5-km-epo (named G32) via Red/ET engineering to increase heterologous polyketide epothilone yields.	Epothilones	80-90	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	52-56
29529178-2	2018	In this work, two multidrug efflux pumps, Orf14 and Orf3, were modulated in the epothilone production strain Burkholderia DSM7029::Tn5-km-epo (named G32) via Red/ET engineering to increase heterologous polyketide epothilone yields.	polyketide epothilone	202-223	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	52-56
29529178-3	2018	Compared with the prior G32 strain, the total production of several epothilones in the G32::orf14-orf3 mutant was meaningfully doubled according to high-performance liquid chromatography-mass spectrometer analysis.	Epothilones	68-79	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	98-102
29529178-4	2018	Typically for epothilone B, in simple and clear liquid medium CYMG, the overall productivity in the engineered high-yield producer G32::orf14-orf3 was improved for almost 3-fold, from 2.7 to about 8.1 mug/l.	epothilone B	14-26	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	142-146
29529178-4	2018	Typically for epothilone B, in simple and clear liquid medium CYMG, the overall productivity in the engineered high-yield producer G32::orf14-orf3 was improved for almost 3-fold, from 2.7 to about 8.1 mug/l.	cymg	62-66	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	142-146
29529178-5	2018	Additionally, the ratio of extracellular to intracellular accumulation of epothilone B was raised from 9.3:1 to 13.7:1 in response to expression of two putative transport genes orf14 and orf3.	epothilone B	74-86	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	187-191
29529178-6	2018	Hence, we strongly recommend that the Orf14 and Orf3 transporters export epothilone, thus promotes the forward reaction of biosynthesis on epothilone manufacture inside the cells.	Epothilones	73-83	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	48-52
29529178-6	2018	Hence, we strongly recommend that the Orf14 and Orf3 transporters export epothilone, thus promotes the forward reaction of biosynthesis on epothilone manufacture inside the cells.	Epothilones	139-149	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	48-52
29471051-9	2018	Wt and an ORF3 mutant with leucine at aa 98 (ORF3-L98) replicated efficiently (density 1.15-1.16 g/cm3), while ORF3-L93 + L96 exhibited a decreased viral release and banded at 1.26-1.27 g/cm3, similar to DeltaORF3.	Leucine	27-34	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	10-14
29471051-9	2018	Wt and an ORF3 mutant with leucine at aa 98 (ORF3-L98) replicated efficiently (density 1.15-1.16 g/cm3), while ORF3-L93 + L96 exhibited a decreased viral release and banded at 1.26-1.27 g/cm3, similar to DeltaORF3.	Leucine	27-34	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	45-49
29471051-9	2018	Wt and an ORF3 mutant with leucine at aa 98 (ORF3-L98) replicated efficiently (density 1.15-1.16 g/cm3), while ORF3-L93 + L96 exhibited a decreased viral release and banded at 1.26-1.27 g/cm3, similar to DeltaORF3.	Leucine	27-34	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	45-49
29471051-10	2018	In conclusion, the ORF3 protein, especially its proline residues at aa 93 and 96, is essential for the release of membrane-associated ratHEV particles, and ORF4 is unnecessary for the replication of ratHEV.	Proline	48-55	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	19-23
29471051-8	2018	ORF3 mutants with proline-to-leucine mutations at amino acids (aa) 93, 96 and/or 98 in ORF3 were constructed and transfected into PLC/PRF/5 cells.	Leucine	29-36	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	0-4
28494112-0	2017	Using the Lewis Acid Me3 Si-F-Al(ORF )3 To Prepare Phosphino-Phosphonium Cations with the Least-Coordinating Anion [(RF O)3 Al-F-Al(ORF )3 ].	lewis acid me3	10-24	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	28-39
30278453-0	2018	Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3.	3-Carboxyumbelliferyl beta-D-galactopyranoside	101-104	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	128-132
28494112-0	2017	Using the Lewis Acid Me3 Si-F-Al(ORF )3 To Prepare Phosphino-Phosphonium Cations with the Least-Coordinating Anion [(RF O)3 Al-F-Al(ORF )3 ].	lewis acid me3	10-24	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	127-138
28494112-0	2017	Using the Lewis Acid Me3 Si-F-Al(ORF )3 To Prepare Phosphino-Phosphonium Cations with the Least-Coordinating Anion [(RF O)3 Al-F-Al(ORF )3 ].	phosphino-phosphonium	51-72	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	28-39
28494112-0	2017	Using the Lewis Acid Me3 Si-F-Al(ORF )3 To Prepare Phosphino-Phosphonium Cations with the Least-Coordinating Anion [(RF O)3 Al-F-Al(ORF )3 ].	phosphino-phosphonium	51-72	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	127-138
28494112-1	2017	By reaction of two equivalents of Me3 Si-F-Al(ORF )3 1 with an equimolar amount of PPh2 Cl, the salt [Ph2 P-PPh2 Cl]+ [(RF O)3 Al-F-Al(ORF )3 ]- 2 is prepared smoothly in 91 % yield (NMR, XRD).	al-f-al	127-134	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	41-52
28494112-1	2017	By reaction of two equivalents of Me3 Si-F-Al(ORF )3 1 with an equimolar amount of PPh2 Cl, the salt [Ph2 P-PPh2 Cl]+ [(RF O)3 Al-F-Al(ORF )3 ]- 2 is prepared smoothly in 91 % yield (NMR, XRD).	al-f-al	127-134	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	46-52
28494112-2	2017	The synthesis of [Ph2 P-PPh3 ]+ [(RF O)3 Al-F-Al(ORF )3 ]- 3 is best achieved by a two-step reaction: first, two equivalents of 1 react with one PPh3 to give [Me3 Si-PPh3 ]+ [(RF O)3 Al-F-Al(ORF )3 ]- 4 (NMR, XRD), which, upon reaction with PPh2 Cl, yields pure 3 and Me3 SiCl (NMR, XRD).	RUTHENIUM-PYRIDOCARBAZOLE-3	159-162	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	49-55
28494112-4	2017	Otherwise, the residual strong Lewis acidity of the [(RF O)3 Al-F-Al(ORF )3 ]- anion in the presence of the [F-Al(ORF )3 ]- anion-that forms with less than two equivalents of 1-leads to further chloride exchange reactions that complicate work-up.	Chlorides	194-202	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	69-75
28494112-4	2017	Otherwise, the residual strong Lewis acidity of the [(RF O)3 Al-F-Al(ORF )3 ]- anion in the presence of the [F-Al(ORF )3 ]- anion-that forms with less than two equivalents of 1-leads to further chloride exchange reactions that complicate work-up.	Chlorides	194-202	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	64-75
27638774-3	2016	Anti-ORF3 MAbs could capture ratHEV particles in culture supernatant and serum following treatment with 0.5 % deoxycholate, but not those without prior detergent treatment or fecal ratHEV particles.	Deoxycholic Acid	110-122	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	5-9
27638774-4	2016	Following treatment with 0.5 % deoxycholate and 0.5 % trypsin, the buoyant density of ratHEV particles in culture supernatant with ORF3 protein on the surface shifted from 1.15 g/cm3 to 1.26 g/cm3 in a sucrose gradient; the resulting particles were capturable by an anti-ORF2 MAb but not by an anti-ORF3 MAb.	Deoxycholic Acid	31-43	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	131-135
27638774-4	2016	Following treatment with 0.5 % deoxycholate and 0.5 % trypsin, the buoyant density of ratHEV particles in culture supernatant with ORF3 protein on the surface shifted from 1.15 g/cm3 to 1.26 g/cm3 in a sucrose gradient; the resulting particles were capturable by an anti-ORF2 MAb but not by an anti-ORF3 MAb.	Deoxycholic Acid	31-43	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	299-303
27638774-4	2016	Following treatment with 0.5 % deoxycholate and 0.5 % trypsin, the buoyant density of ratHEV particles in culture supernatant with ORF3 protein on the surface shifted from 1.15 g/cm3 to 1.26 g/cm3 in a sucrose gradient; the resulting particles were capturable by an anti-ORF2 MAb but not by an anti-ORF3 MAb.	Sucrose	202-209	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	131-135
27593411-4	2016	An attempt to prepare [Au(L)2 ]+ units, even with less weakly basic solvents like CH2 Cl2 , led to decomposition of the [Al(ORF )4 ]- anion and formation of [NO(CH2 Cl2 )2 ]+ [F(Al(ORF )3 )2 ]- .	au(l)2	23-29	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	181-187
27593411-4	2016	An attempt to prepare [Au(L)2 ]+ units, even with less weakly basic solvents like CH2 Cl2 , led to decomposition of the [Al(ORF )4 ]- anion and formation of [NO(CH2 Cl2 )2 ]+ [F(Al(ORF )3 )2 ]- .	Methylene Chloride	82-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	181-187
27593411-4	2016	An attempt to prepare [Au(L)2 ]+ units, even with less weakly basic solvents like CH2 Cl2 , led to decomposition of the [Al(ORF )4 ]- anion and formation of [NO(CH2 Cl2 )2 ]+ [F(Al(ORF )3 )2 ]- .	[no(ch2 cl2 )2	157-171	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	181-187