PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
1726427-1	1991	In an attempt to produce more powerful (effective) bombesin/GRP receptor antagonists, the D forms of Trp or Trp analog (Tpi) were introduced at position 6 in two pseudononapeptides, Leu13 psi (CH2NH)Leu14-bombesin(6-14) and Leu13 psi(CH2NH)Phe14-bombesin (6-14).	Tryptophan	108-111	triosephosphate isomerase 1	Mus musculus	120-123
1892247-2	1991	CASB and CASK segregated together and IGF-1 and LALBA were found syntenic with the LDHB-PEPB-TPI-GAPD-SHMT-KRTB group.	krtb	107-111	triosephosphate isomerase 1	Mus musculus	93-96
2055457-1	1991	A mutation resulting in increased triosephosphate isomerase (TPI) activity in blood was recovered in offspring of procarbazine hydrochloride-treated male mice.	Procarbazine	114-140	triosephosphate isomerase 1	Mus musculus	34-59
2055457-1	1991	A mutation resulting in increased triosephosphate isomerase (TPI) activity in blood was recovered in offspring of procarbazine hydrochloride-treated male mice.	Procarbazine	114-140	triosephosphate isomerase 1	Mus musculus	61-64
2693209-1	1989	Four heterozygous triosephosphate isomerase (TPI) mutants with approximately 50% reduced activity in blood compared to wild type were detected in offspring of 1-ethyl-1-nitrosourea treated male mice.	Ethylnitrosourea	159-180	triosephosphate isomerase 1	Mus musculus	18-43
33333866-1	2020	Trifluridine/tipiracil (FTD/TPI) (a.k.a.	trifluridine tipiracil drug combination	0-22	triosephosphate isomerase 1	Mus musculus	28-31
2693209-1	1989	Four heterozygous triosephosphate isomerase (TPI) mutants with approximately 50% reduced activity in blood compared to wild type were detected in offspring of 1-ethyl-1-nitrosourea treated male mice.	Ethylnitrosourea	159-180	triosephosphate isomerase 1	Mus musculus	45-48
3541973-2	1986	While both TPI-d and TPI-n displayed identical properties on sodium dodecyl sulfate-polyacrylamide gels (14,800 relative mass), analytical isoelectric focusing gels (pI 4.5), and high performance liquid chromatography columns, TPI-d was unable to inhibit papain and cathepsin B after purification by isoelectric focusing.	Sodium Dodecyl Sulfate	61-83	triosephosphate isomerase 1	Mus musculus	11-14
3541973-2	1986	While both TPI-d and TPI-n displayed identical properties on sodium dodecyl sulfate-polyacrylamide gels (14,800 relative mass), analytical isoelectric focusing gels (pI 4.5), and high performance liquid chromatography columns, TPI-d was unable to inhibit papain and cathepsin B after purification by isoelectric focusing.	Sodium Dodecyl Sulfate	61-83	triosephosphate isomerase 1	Mus musculus	21-24
3541973-2	1986	While both TPI-d and TPI-n displayed identical properties on sodium dodecyl sulfate-polyacrylamide gels (14,800 relative mass), analytical isoelectric focusing gels (pI 4.5), and high performance liquid chromatography columns, TPI-d was unable to inhibit papain and cathepsin B after purification by isoelectric focusing.	Sodium Dodecyl Sulfate	61-83	triosephosphate isomerase 1	Mus musculus	21-24
3541973-2	1986	While both TPI-d and TPI-n displayed identical properties on sodium dodecyl sulfate-polyacrylamide gels (14,800 relative mass), analytical isoelectric focusing gels (pI 4.5), and high performance liquid chromatography columns, TPI-d was unable to inhibit papain and cathepsin B after purification by isoelectric focusing.	polyacrylamide	84-98	triosephosphate isomerase 1	Mus musculus	11-14
3541973-2	1986	While both TPI-d and TPI-n displayed identical properties on sodium dodecyl sulfate-polyacrylamide gels (14,800 relative mass), analytical isoelectric focusing gels (pI 4.5), and high performance liquid chromatography columns, TPI-d was unable to inhibit papain and cathepsin B after purification by isoelectric focusing.	polyacrylamide	84-98	triosephosphate isomerase 1	Mus musculus	21-24
3541973-2	1986	While both TPI-d and TPI-n displayed identical properties on sodium dodecyl sulfate-polyacrylamide gels (14,800 relative mass), analytical isoelectric focusing gels (pI 4.5), and high performance liquid chromatography columns, TPI-d was unable to inhibit papain and cathepsin B after purification by isoelectric focusing.	polyacrylamide	84-98	triosephosphate isomerase 1	Mus musculus	21-24
4045457-5	1985	In contrast, with 0.1% Triton X-100 in isotonic phosphate-buffered saline, when 70% of the inositol was extracted, 33% of the aldolase and 48% of the triose phosphate isomerase were extracted.	Octoxynol	23-35	triosephosphate isomerase 1	Mus musculus	150-176
6959824-2	1982	When FELCs were incubated for short periods with 32Pi before cell fractionation, the lipid-bound radioactivity was almost exclusively present in phosphatidylinositol-4-phosphate (DPI) and phosphatidylinositol-4,5-bisphosphate (TPI), and its distribution closely matched that of the plasma membrane markers.	32pi	49-53	triosephosphate isomerase 1	Mus musculus	227-230
33333866-2	2020	TAS-102) is a combination drug for metastatic colorectal cancer (CRC) and severely pretreated metastatic gastric/gastroesophageal junction (GEJ) cancers, comprising FTD, a thymidine-based antineoplastic nucleoside analog, and TPI, which enhances FTD bioavailability.	trifluridine tipiracil drug combination	0-7	triosephosphate isomerase 1	Mus musculus	226-229
23878000-8	2013	Immunofluorescence with sodium dodecyl sulfate (SDS)-insoluble flagellar accessory structures showed a strong TPI1 signal only in the principal piece, indicating that TPI1 is a component of the fibrous sheath.	Sodium Dodecyl Sulfate	24-46	triosephosphate isomerase 1	Mus musculus	110-114
29549725-4	2018	MTT assay displayed that the total ethanol extract of P. igniarius (TPI) had antitumor activities against five human tumor cell lines of HepG-2, AGS, SGC-7901, Hela and A-549.	monooxyethylene trimethylolpropane tristearate	0-3	triosephosphate isomerase 1	Mus musculus	68-71
29549725-4	2018	MTT assay displayed that the total ethanol extract of P. igniarius (TPI) had antitumor activities against five human tumor cell lines of HepG-2, AGS, SGC-7901, Hela and A-549.	Ethanol	35-42	triosephosphate isomerase 1	Mus musculus	68-71
29491068-1	2018	BACKGROUND/AIM: Trifluridine/tipiracil (FTD/TPI) is used for metastatic colorectal cancer, that is refractory to 5-fluorouracil (5-FU)-based therapies.	Trifluridine	16-28	triosephosphate isomerase 1	Mus musculus	44-47
29491068-1	2018	BACKGROUND/AIM: Trifluridine/tipiracil (FTD/TPI) is used for metastatic colorectal cancer, that is refractory to 5-fluorouracil (5-FU)-based therapies.	tipiracil	29-38	triosephosphate isomerase 1	Mus musculus	44-47
29491068-1	2018	BACKGROUND/AIM: Trifluridine/tipiracil (FTD/TPI) is used for metastatic colorectal cancer, that is refractory to 5-fluorouracil (5-FU)-based therapies.	Fluorouracil	113-127	triosephosphate isomerase 1	Mus musculus	44-47
29491068-1	2018	BACKGROUND/AIM: Trifluridine/tipiracil (FTD/TPI) is used for metastatic colorectal cancer, that is refractory to 5-fluorouracil (5-FU)-based therapies.	Fluorouracil	129-133	triosephosphate isomerase 1	Mus musculus	44-47
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	Trifluridine	0-12	triosephosphate isomerase 1	Mus musculus	28-31
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	Trifluridine	0-12	triosephosphate isomerase 1	Mus musculus	115-118
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	tipiracil	13-22	triosephosphate isomerase 1	Mus musculus	28-31
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	tipiracil	13-22	triosephosphate isomerase 1	Mus musculus	115-118
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	Thymidine	76-85	triosephosphate isomerase 1	Mus musculus	28-31
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	Nucleosides	92-102	triosephosphate isomerase 1	Mus musculus	28-31
26714844-5	2015	Whether injected with Tat-TPI in foot pad or vaccinated with Tat-TPI in the back subcutaneously for three times, the draining popliteal lymph nodes and spleen both developed a stronger CD8(+)T response (Tc1) in mice.	cd8(+)t	185-192	triosephosphate isomerase 1	Mus musculus	26-29
26714844-5	2015	Whether injected with Tat-TPI in foot pad or vaccinated with Tat-TPI in the back subcutaneously for three times, the draining popliteal lymph nodes and spleen both developed a stronger CD8(+)T response (Tc1) in mice.	cd8(+)t	185-192	triosephosphate isomerase 1	Mus musculus	65-68
24693223-10	2014	The application of 2D gel electrophoresis to analyze the rutin-responsive protein profiles in the WFST mouse brain further revealed the upregulation of the CB1 cannabinoid receptor-interacting protein 1, myelin basic protein, Rho GDP dissociation inhibitor (GDI) alpha, and TPI, indicating that rutin might inhibit anxiety through the upregulation of the expression of anxiety-associated proteins.	Rutin	57-62	triosephosphate isomerase 1	Mus musculus	274-277
31111503-4	2019	We generated a mouse model in which exchange of a conserved catalytic amino acid residue (isoleucine to valine, Ile170Val) reduces TPI specific activity without affecting the stability of the protein dimer.	Isoleucine	90-100	triosephosphate isomerase 1	Mus musculus	131-134
31111503-4	2019	We generated a mouse model in which exchange of a conserved catalytic amino acid residue (isoleucine to valine, Ile170Val) reduces TPI specific activity without affecting the stability of the protein dimer.	Valine	104-110	triosephosphate isomerase 1	Mus musculus	131-134
31111503-4	2019	We generated a mouse model in which exchange of a conserved catalytic amino acid residue (isoleucine to valine, Ile170Val) reduces TPI specific activity without affecting the stability of the protein dimer.	ile170val	112-121	triosephosphate isomerase 1	Mus musculus	131-134
26651386-5	2016	The TPI-1954 library is a pyrrolidine bis-piperazine and totals 738,192 compounds.	pyrrolidine bis-piperazine	26-52	triosephosphate isomerase 1	Mus musculus	4-7
24757211-1	2014	ABSTRACT Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P).	Dihydroxyacetone Phosphate	74-100	triosephosphate isomerase 1	Mus musculus	36-39
24757211-1	2014	ABSTRACT Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P).	Dihydroxyacetone Phosphate	102-106	triosephosphate isomerase 1	Mus musculus	36-39
24757211-1	2014	ABSTRACT Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P).	Glyceraldehyde 3-Phosphate	112-138	triosephosphate isomerase 1	Mus musculus	36-39
24757211-1	2014	ABSTRACT Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P).	Glyceraldehyde 3-Phosphate	140-143	triosephosphate isomerase 1	Mus musculus	36-39
24757211-3	2014	However, when studying a conditionally regulated tpi knockdown mutant, we noticed that depletion of TPI reduced growth of M. tuberculosis in media containing a single carbon source but not in media that contained both a glycolytic and a gluconeogenic carbon source.	Carbon	167-173	triosephosphate isomerase 1	Mus musculus	100-103
24757211-3	2014	However, when studying a conditionally regulated tpi knockdown mutant, we noticed that depletion of TPI reduced growth of M. tuberculosis in media containing a single carbon source but not in media that contained both a glycolytic and a gluconeogenic carbon source.	Carbon	251-257	triosephosphate isomerase 1	Mus musculus	100-103
24757211-4	2014	We used such two-carbon-source media to isolate a tpi deletion (Deltatpi) mutant.	Carbon	17-23	triosephosphate isomerase 1	Mus musculus	50-53
23878000-8	2013	Immunofluorescence with sodium dodecyl sulfate (SDS)-insoluble flagellar accessory structures showed a strong TPI1 signal only in the principal piece, indicating that TPI1 is a component of the fibrous sheath.	Sodium Dodecyl Sulfate	24-46	triosephosphate isomerase 1	Mus musculus	167-171
23878000-8	2013	Immunofluorescence with sodium dodecyl sulfate (SDS)-insoluble flagellar accessory structures showed a strong TPI1 signal only in the principal piece, indicating that TPI1 is a component of the fibrous sheath.	Sodium Dodecyl Sulfate	48-51	triosephosphate isomerase 1	Mus musculus	110-114
23878000-8	2013	Immunofluorescence with sodium dodecyl sulfate (SDS)-insoluble flagellar accessory structures showed a strong TPI1 signal only in the principal piece, indicating that TPI1 is a component of the fibrous sheath.	Sodium Dodecyl Sulfate	48-51	triosephosphate isomerase 1	Mus musculus	167-171
15001397-4	2004	When cells expressing the recombinant TPI protein with histidine tag were exposed to hypoxia and the TPI protein was affinity-purified, the catalytic activity (specific activity) of the TPI protein purified from hypoxic cells was substantially lower than that obtained from normoxic cells.	Histidine	55-64	triosephosphate isomerase 1	Mus musculus	38-41
19493007-1	2009	The glycolytic enzyme triosephosphate isomerase (tpi) (EC 5.3.1.1) plays a key role in central carbon metabolism yet few studies have characterized isogenic bacterial mutants lacking this enzyme and none have examined its role in the in vivo fitness of a bacterial pathogen.	Carbon	95-101	triosephosphate isomerase 1	Mus musculus	49-52
19220926-1	2009	A triosephosphate isomerase (TPI) mutant, Tpi1(a-m6Neu), with approximately 57% residual enzyme activity in blood compared with wild-type was detected among offspring of triethylenemelamine-treated male mice.	Triethylenemelamine	170-189	triosephosphate isomerase 1	Mus musculus	2-27
19220926-1	2009	A triosephosphate isomerase (TPI) mutant, Tpi1(a-m6Neu), with approximately 57% residual enzyme activity in blood compared with wild-type was detected among offspring of triethylenemelamine-treated male mice.	Triethylenemelamine	170-189	triosephosphate isomerase 1	Mus musculus	29-32
19220926-1	2009	A triosephosphate isomerase (TPI) mutant, Tpi1(a-m6Neu), with approximately 57% residual enzyme activity in blood compared with wild-type was detected among offspring of triethylenemelamine-treated male mice.	Triethylenemelamine	170-189	triosephosphate isomerase 1	Mus musculus	42-54
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	triosephosphates	112-128	triosephosphate isomerase 1	Mus musculus	4-29
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	triosephosphates	112-128	triosephosphate isomerase 1	Mus musculus	31-34
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	alpha-glycerophosphoric acid	213-233	triosephosphate isomerase 1	Mus musculus	4-29
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	alpha-glycerophosphoric acid	213-233	triosephosphate isomerase 1	Mus musculus	31-34
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	Pentosephosphates	253-270	triosephosphate isomerase 1	Mus musculus	4-29
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	Pentosephosphates	253-270	triosephosphate isomerase 1	Mus musculus	31-34
19786097-5	2009	The impairment of TPI activity apparently does not affect the energy metabolism at system level; however, it results in accumulation of dihydroxyacetone phosphate followed by its chemical conversion into the toxic methylglyoxal, leading to the formation of advanced glycation end products.	Dihydroxyacetone Phosphate	136-162	triosephosphate isomerase 1	Mus musculus	18-21
14719072-1	2004	TAS-102 is a new oral anti-cancer drug preparation, composed of a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-trifluorothymidine (FTD) and 5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (TPI).	trifluridine tipiracil drug combination	0-7	triosephosphate isomerase 1	Mus musculus	234-237
14719072-10	2004	Thymidine (dThd) levels rescued the effect of FTD in vitro and significantly increased in serum after administration of TAS-102 or TPI alone but not FTD alone.	Thymidine	0-9	triosephosphate isomerase 1	Mus musculus	131-134
14719072-10	2004	Thymidine (dThd) levels rescued the effect of FTD in vitro and significantly increased in serum after administration of TAS-102 or TPI alone but not FTD alone.	Thymidine	11-15	triosephosphate isomerase 1	Mus musculus	131-134
14719072-12	2004	However, our study indicated that the therapeutic index was clearly increased by FTD combined with TPI, compared with FTD alone, suggesting FTD-induced toxicity to sensitive host tissue can be selectively reversed with dThd.	Thymidine	219-223	triosephosphate isomerase 1	Mus musculus	99-102
14719072-13	2004	In conclusion, TK and TPI effects on TP play important roles in the cytotoxic action of TAS-102, and it is possible to use the TK/TP ratio to predict more precisely individual resistance or sensitivity.	trifluridine tipiracil drug combination	88-95	triosephosphate isomerase 1	Mus musculus	22-25
9702787-2	1998	To examine the consequences of GAPDH inhibition upon neuronal survival, we exposed murine neocortical cell cultures to the inhibitor of GAPDH and triosephosphate isomerase, alpha-monochlorohydrin.	alpha-Chlorohydrin	179-195	triosephosphate isomerase 1	Mus musculus	146-171
7739600-6	1995	Tpi*M-4NEU contained a T:A to A:T transversion within the codon for residue 162 in exon 5, also causing a Leu to Gln substitution.	Leucine	106-109	triosephosphate isomerase 1	Mus musculus	0-3
7739600-6	1995	Tpi*M-4NEU contained a T:A to A:T transversion within the codon for residue 162 in exon 5, also causing a Leu to Gln substitution.	Glutamine	113-116	triosephosphate isomerase 1	Mus musculus	0-3
7739600-8	1995	Sequence analysis of Tpi*M-3NEU revealed an A:T to C:G transversion, changing the stop codon to a codon for Cys, with the resulting addition of 19 predominantly hydrophobic amino acids to the protein.	Cysteine	108-111	triosephosphate isomerase 1	Mus musculus	21-24