PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
492880-4	1979	The data also hint at a possible relationship between n-Ach and accuracy of visual recognition in the left hemisphere.	n-ach	54-59	histidine triad nucleotide binding protein 1	Homo sapiens	14-18
6189000-7	1983	In the laters, on the contrary, positivity of Naloxone Test seems to hint at the activation of endorphine.	Naloxone	46-54	histidine triad nucleotide binding protein 1	Homo sapiens	69-73
6189000-7	1983	In the laters, on the contrary, positivity of Naloxone Test seems to hint at the activation of endorphine.	endorphine	95-105	histidine triad nucleotide binding protein 1	Homo sapiens	69-73
7439031-1	1980	In several former papers on baker"s eczema authors happened to hint at hypersensitivity to chromium in bakers suffering from eczema.	Chromium	91-99	histidine triad nucleotide binding protein 1	Homo sapiens	63-67
33230623-3	2021	Once taken up by cells it is converted by anchimeric activation of the lipophilic 2-(methylthio) ethyl protecting group and after that Hint1 P-N bond cleavage to N7-(p-chlorophenoxyethyl) guanosine 5"-monophosphate (7-Cl-Ph-Ethyl-GMP).	2-(methylthio) ethyl	82-102	histidine triad nucleotide binding protein 1	Homo sapiens	135-140
33230623-3	2021	Once taken up by cells it is converted by anchimeric activation of the lipophilic 2-(methylthio) ethyl protecting group and after that Hint1 P-N bond cleavage to N7-(p-chlorophenoxyethyl) guanosine 5"-monophosphate (7-Cl-Ph-Ethyl-GMP).	n7-(p-chlorophenoxyethyl) guanosine 5"-monophosphate	162-214	histidine triad nucleotide binding protein 1	Homo sapiens	135-140
33230623-3	2021	Once taken up by cells it is converted by anchimeric activation of the lipophilic 2-(methylthio) ethyl protecting group and after that Hint1 P-N bond cleavage to N7-(p-chlorophenoxyethyl) guanosine 5"-monophosphate (7-Cl-Ph-Ethyl-GMP).	7-cl-ph-ethyl-gmp	216-233	histidine triad nucleotide binding protein 1	Homo sapiens	135-140
33276572-0	2020	Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules.	Water	163-168	histidine triad nucleotide binding protein 1	Homo sapiens	137-141
33581212-4	2021	Pimodivir potently inhibited virus replication in two assays, a single-cycle HINT and a multi-cycle FRA, with IC50 values in a nanomolar range.	pimodivir	0-9	histidine triad nucleotide binding protein 1	Homo sapiens	77-81
32483857-1	2021	The diurnal nature of restless legs syndrome (RLS) and its response to dopamine hint that hormones are central in RLS pathophysiology.	Dopamine	71-79	histidine triad nucleotide binding protein 1	Homo sapiens	80-84
33379368-3	2020	The glutamate N-methyl-d-aspartate receptor (NMDAR), which plays a relevant role in allodynia to mechanical stimuli, is connected via histidine triad nucleotide-binding protein 1 (HINT1) and type 1 sigma receptor (sigma1R) to mu-opioid receptors (MORs), which mediate the most potent pain relief.	Glutamic Acid	4-13	histidine triad nucleotide binding protein 1	Homo sapiens	134-178
33379368-3	2020	The glutamate N-methyl-d-aspartate receptor (NMDAR), which plays a relevant role in allodynia to mechanical stimuli, is connected via histidine triad nucleotide-binding protein 1 (HINT1) and type 1 sigma receptor (sigma1R) to mu-opioid receptors (MORs), which mediate the most potent pain relief.	Glutamic Acid	4-13	histidine triad nucleotide binding protein 1	Homo sapiens	180-185
33404983-6	2021	Moreover, HINT1 mutants exhibited anomalous interactions with G protein coupled receptors, such as the mu-opioid, and with glutamate N-methyl-D-aspartate receptors as well.	Glutamic Acid	123-132	histidine triad nucleotide binding protein 1	Homo sapiens	10-15
33404983-6	2021	Moreover, HINT1 mutants exhibited anomalous interactions with G protein coupled receptors, such as the mu-opioid, and with glutamate N-methyl-D-aspartate receptors as well.	N-Methylaspartate	133-153	histidine triad nucleotide binding protein 1	Homo sapiens	10-15
32467727-7	2020	The reason is that T-protein of the GCS can degrade methylamine-loaded H-protein (Hint) to formaldehyde and ammonia, accompanied with the formation of dihydrolipoyl H-protein (Hred), but the reaction rate is less than 0.16% of that in the presence of THF.	tetrahydrofuran	251-254	histidine triad nucleotide binding protein 1	Homo sapiens	82-86
32370497-4	2020	Our observations regarding a facile conversion of (-)-capsicodendrin back to (-)-cinnamodial hint at the possibility that (-)-capsicodendrin is a chemical reservoir of insecticidal (-)-cinnamodial and Cinnamosma genus plants release it upon environmental stresses.	(-)-capsicodendrin	122-140	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
32467727-7	2020	The reason is that T-protein of the GCS can degrade methylamine-loaded H-protein (Hint) to formaldehyde and ammonia, accompanied with the formation of dihydrolipoyl H-protein (Hred), but the reaction rate is less than 0.16% of that in the presence of THF.	methylamine	52-63	histidine triad nucleotide binding protein 1	Homo sapiens	82-86
32467727-7	2020	The reason is that T-protein of the GCS can degrade methylamine-loaded H-protein (Hint) to formaldehyde and ammonia, accompanied with the formation of dihydrolipoyl H-protein (Hred), but the reaction rate is less than 0.16% of that in the presence of THF.	Formaldehyde	91-103	histidine triad nucleotide binding protein 1	Homo sapiens	82-86
32944137-2	2020	One strategy, termed "ProTide", masks the anionic phosphate through an N-linked amino ester and an O-linked aromatic phospho-ester, such that release of the active drug requires consecutive enzymatic liberation by an esterase and then a phosphoramidase, such as Hint1.	CHEBI:29300	22-29	histidine triad nucleotide binding protein 1	Homo sapiens	262-267
32944137-2	2020	One strategy, termed "ProTide", masks the anionic phosphate through an N-linked amino ester and an O-linked aromatic phospho-ester, such that release of the active drug requires consecutive enzymatic liberation by an esterase and then a phosphoramidase, such as Hint1.	Phosphates	50-59	histidine triad nucleotide binding protein 1	Homo sapiens	262-267
32944137-2	2020	One strategy, termed "ProTide", masks the anionic phosphate through an N-linked amino ester and an O-linked aromatic phospho-ester, such that release of the active drug requires consecutive enzymatic liberation by an esterase and then a phosphoramidase, such as Hint1.	n-linked amino ester	71-91	histidine triad nucleotide binding protein 1	Homo sapiens	262-267
32944137-2	2020	One strategy, termed "ProTide", masks the anionic phosphate through an N-linked amino ester and an O-linked aromatic phospho-ester, such that release of the active drug requires consecutive enzymatic liberation by an esterase and then a phosphoramidase, such as Hint1.	phospho-ester	117-130	histidine triad nucleotide binding protein 1	Homo sapiens	262-267
32467727-7	2020	The reason is that T-protein of the GCS can degrade methylamine-loaded H-protein (Hint) to formaldehyde and ammonia, accompanied with the formation of dihydrolipoyl H-protein (Hred), but the reaction rate is less than 0.16% of that in the presence of THF.	Ammonia	108-115	histidine triad nucleotide binding protein 1	Homo sapiens	82-86
32467727-8	2020	Increasing T-protein concentration can speed up the release rate of formaldehyde by Hint.	Formaldehyde	68-80	histidine triad nucleotide binding protein 1	Homo sapiens	84-88
32098277-0	2020	Pharmacological Targets of Kaempferol Within Inflammatory Pathways-A Hint Towards the Central Role of Tryptophan Metabolism.	kaempferol	27-37	histidine triad nucleotide binding protein 1	Homo sapiens	69-73
31990367-0	2020	Histidine triad nucleotide-binding proteins HINT1 and HINT2 Share Similar Substrate Specificities and Little Affinity for the Signaling Dinucleotide Ap4A.	histidine-pyridine-histidine-3	0-9	histidine triad nucleotide binding protein 1	Homo sapiens	44-49
31990367-0	2020	Histidine triad nucleotide-binding proteins HINT1 and HINT2 Share Similar Substrate Specificities and Little Affinity for the Signaling Dinucleotide Ap4A.	cytidylyl-3'-5'-guanosine	136-148	histidine triad nucleotide binding protein 1	Homo sapiens	44-49
31990367-2	2020	Here, a similar substrate specificity profile (kcat /Km ) for model phosphoramidate substrates was found for hHINT2 but with higher kcat and Km values when compared with hHINT1.	phosphoramidic acid	68-83	histidine triad nucleotide binding protein 1	Homo sapiens	170-176
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	69-78	histidine triad nucleotide binding protein 1	Homo sapiens	0-42
31974652-2	2020	The nucleoside monophosphate Protide, 4Ei-10, undergoes intracellular uptake and conversion by Hint1 to form 7-Cl-Ph-Ethyl-GMP.	nucleoside monophosphate sugars	4-28	histidine triad nucleotide binding protein 1	Homo sapiens	95-100
31974652-2	2020	The nucleoside monophosphate Protide, 4Ei-10, undergoes intracellular uptake and conversion by Hint1 to form 7-Cl-Ph-Ethyl-GMP.	2'-guanylic acid	109-126	histidine triad nucleotide binding protein 1	Homo sapiens	95-100
31088288-8	2019	HINT1 sumoylase activity is blocked by zinc, and it is released by nitric oxide or calcium-activated calmodulin (CaM).	Nitric Oxide	67-79	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
31088288-12	2019	Conclusion: The 15 human HINT1 mutants reported to cause ARAN-NM exhibited altered sumoylase activity, which may contribute to the onset of this human motor disease.	aran-	57-62	histidine triad nucleotide binding protein 1	Homo sapiens	25-30
31071329-3	2019	These findings hint at plasma membrane Ca2+-ATPase (PMCA) involvement, as it transports Ca2+ actively to the extracellular medium coupled to ATP hydrolysis, thus maintaining ion cellular homeostasis.	Adenosine Triphosphate	44-47	histidine triad nucleotide binding protein 1	Homo sapiens	15-19
31249525-5	2019	By contrast, the association of HINT1 with these TRPs was moderately dependent on calcium.	Tryptophan	49-53	histidine triad nucleotide binding protein 1	Homo sapiens	32-37
31249525-5	2019	By contrast, the association of HINT1 with these TRPs was moderately dependent on calcium.	Calcium	82-89	histidine triad nucleotide binding protein 1	Homo sapiens	32-37
31347025-8	2019	This analysis uncovers significant isomeric diversity within the fatty acid pool of this sample, including a number of hitherto unreported double bond positional isomers that hint at the activity of potentially new metabolic pathways.	Fatty Acids	65-75	histidine triad nucleotide binding protein 1	Homo sapiens	175-179
30772266-0	2019	The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions.	4-nitrophenyl phosphorothioate	51-67	histidine triad nucleotide binding protein 1	Homo sapiens	16-21
30772266-0	2019	The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions.	Oligonucleotides	68-84	histidine triad nucleotide binding protein 1	Homo sapiens	16-21
30772266-0	2019	The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions.	Deuterium	124-127	histidine triad nucleotide binding protein 1	Homo sapiens	16-21
30772266-3	2019	We hypothesize that the enzyme responsible for (d)NMPS catabolism could be Hint1, an enzyme that belongs to the histidine triad (HIT) superfamily and is present in all organisms.	Histidine	112-121	histidine triad nucleotide binding protein 1	Homo sapiens	75-80
30772266-4	2019	We previously found that (d)NMPS were desulfurated in vitro to yield (d)NMP and H2S in a Hint1-assisted reaction.	N-methylpyrrolidone	28-32	histidine triad nucleotide binding protein 1	Homo sapiens	89-94
30772266-4	2019	We previously found that (d)NMPS were desulfurated in vitro to yield (d)NMP and H2S in a Hint1-assisted reaction.	N-methylpyrrolidone	28-31	histidine triad nucleotide binding protein 1	Homo sapiens	89-94
30772266-4	2019	We previously found that (d)NMPS were desulfurated in vitro to yield (d)NMP and H2S in a Hint1-assisted reaction.	Deuterium	80-83	histidine triad nucleotide binding protein 1	Homo sapiens	89-94
30772266-9	2019	These results suggest that the metabolic pathway of PS-oligos includes hydrolysis into (d)NMPS (by cellular nucleases) followed by Hint1-promoted conversion of the resulting (d)NMPS into (d)NMP accompanied by H2S elimination.	Deuterium	209-212	histidine triad nucleotide binding protein 1	Homo sapiens	131-136
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	69-78	histidine triad nucleotide binding protein 1	Homo sapiens	44-48
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	144-153	histidine triad nucleotide binding protein 1	Homo sapiens	0-42
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	144-153	histidine triad nucleotide binding protein 1	Homo sapiens	44-48
29787766-6	2018	The H112N mutant was found to be dimeric, but devoid of catalytic activity, due to the loss of the catalytically essential histidine; nevertheless, it exhibited high affinity to AMP and a HINT1 inhibitor.	Histidine	123-132	histidine triad nucleotide binding protein 1	Homo sapiens	188-193
29787766-6	2018	The H112N mutant was found to be dimeric, but devoid of catalytic activity, due to the loss of the catalytically essential histidine; nevertheless, it exhibited high affinity to AMP and a HINT1 inhibitor.	Adenosine Monophosphate	178-181	histidine triad nucleotide binding protein 1	Homo sapiens	188-193
29806073-0	2018	Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression.	taraxasterol	0-12	histidine triad nucleotide binding protein 1	Homo sapiens	73-78
29689161-5	2018	We found HINT1"s catalytic hydrolysis of the nucleoside phosphoramidate moieties within the nanofiber structures to induce nanofiber organization and higher ordered assembly.	nucleoside phosphoramidate	45-71	histidine triad nucleotide binding protein 1	Homo sapiens	9-14
29689161-8	2018	This work highlights the self-assembly of phosphoramidate nanofibers and their higher organization triggered by HINT1 enzymatic activity.	phosphoramidic acid	42-57	histidine triad nucleotide binding protein 1	Homo sapiens	112-117
29806073-5	2018	Furthermore, Taraxasterol upregulated Hint1 and Bax, but downregulated Bcl2 and cyclin D1 expression, accompanied by promoting the demethylation in the Hint1 promoter region in liver cancer cells.	taraxasterol	13-25	histidine triad nucleotide binding protein 1	Homo sapiens	38-43
29806073-5	2018	Furthermore, Taraxasterol upregulated Hint1 and Bax, but downregulated Bcl2 and cyclin D1 expression, accompanied by promoting the demethylation in the Hint1 promoter region in liver cancer cells.	taraxasterol	13-25	histidine triad nucleotide binding protein 1	Homo sapiens	152-157
29806073-6	2018	The effects of Taraxasterol were abrogated by Hint1 silencing and partially mitigated by Bax silencing, Bcl2 or cyclin D1 over-expression in HepG2 cells.	taraxasterol	15-27	histidine triad nucleotide binding protein 1	Homo sapiens	46-51
29806073-11	2018	Taraxasterol enhances Hint1 expression by promoting demethylation in Hint1 promoter.	taraxasterol	0-12	histidine triad nucleotide binding protein 1	Homo sapiens	22-27
29806073-11	2018	Taraxasterol enhances Hint1 expression by promoting demethylation in Hint1 promoter.	taraxasterol	0-12	histidine triad nucleotide binding protein 1	Homo sapiens	69-74
29806073-12	2018	Taraxasterol increases Hint1 levels to regulate Bax, Bcl2, and cyclinD1 expression.	taraxasterol	0-12	histidine triad nucleotide binding protein 1	Homo sapiens	23-28
29806073-13	2018	The effects of Taraxasterol are abrogated by Hint1 silencing in liver cancer cells.	taraxasterol	15-27	histidine triad nucleotide binding protein 1	Homo sapiens	45-50
28968488-0	2017	A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.	protides	119-127	histidine triad nucleotide binding protein 1	Homo sapiens	55-99
29436833-8	2018	In addition, photoactive AgCl micromotors demonstrate interesting gravitactic behaviors that hint at three-dimensional transport or sensing applications.	silver chloride	25-29	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
29277307-3	2018	Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5"-monophosphate delivery.	protides	84-92	histidine triad nucleotide binding protein 1	Homo sapiens	221-225
29277307-3	2018	Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5"-monophosphate delivery.	5-fluorouridine	104-117	histidine triad nucleotide binding protein 1	Homo sapiens	221-225
29277307-3	2018	Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5"-monophosphate delivery.	phosphoramidic acid	285-300	histidine triad nucleotide binding protein 1	Homo sapiens	150-154
29277307-3	2018	Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5"-monophosphate delivery.	phosphoramidic acid	285-300	histidine triad nucleotide binding protein 1	Homo sapiens	221-225
29277307-3	2018	Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5"-monophosphate delivery.	nucleoside 5"-monophosphate	350-377	histidine triad nucleotide binding protein 1	Homo sapiens	150-154
29277307-3	2018	Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5"-monophosphate delivery.	nucleoside 5"-monophosphate	350-377	histidine triad nucleotide binding protein 1	Homo sapiens	221-225
29177353-2	2017	Recently, inhibition of histidine nucleotide binding protein 1 (Hint1) with a small nucleoside inhibitor has shown promise as a new therapeutic strategy for the treatment of neuropathic pain.	Nucleosides	84-94	histidine triad nucleotide binding protein 1	Homo sapiens	24-62
29177353-2	2017	Recently, inhibition of histidine nucleotide binding protein 1 (Hint1) with a small nucleoside inhibitor has shown promise as a new therapeutic strategy for the treatment of neuropathic pain.	Nucleosides	84-94	histidine triad nucleotide binding protein 1	Homo sapiens	64-69
28968488-0	2017	A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.	protides	119-127	histidine triad nucleotide binding protein 1	Homo sapiens	101-107
28968488-2	2017	In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleotide monophosphate.	protides	11-19	histidine triad nucleotide binding protein 1	Homo sapiens	44-88
28968488-2	2017	In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleotide monophosphate.	protides	11-19	histidine triad nucleotide binding protein 1	Homo sapiens	90-96
28968488-2	2017	In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleotide monophosphate.	nucleotide monophosphate	112-136	histidine triad nucleotide binding protein 1	Homo sapiens	44-88
28968488-2	2017	In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleotide monophosphate.	nucleotide monophosphate	112-136	histidine triad nucleotide binding protein 1	Homo sapiens	90-96
28968488-4	2017	To better understand the diversity of potential substrates of hHint1, we created and studied a series of phosphoramidate nucleosides.	phosphoramidate nucleosides	105-132	histidine triad nucleotide binding protein 1	Homo sapiens	62-68
29125116-1	2017	The histidine triad nucleotide binding protein1(HINT1),which belongs to the histidine triad(HIT) enzyme superfamily,exerts its enzymic activities as hydrolase or transferase.	Histidine	4-13	histidine triad nucleotide binding protein 1	Homo sapiens	48-53
28947944-2	2017	The proTide incorporates a chemically cleavable 2-(methylthio)ethyl moiety and a HINT1 hydrolyzable tryptamine phosphoramidate.	CHEBI:29300	4-11	histidine triad nucleotide binding protein 1	Homo sapiens	81-86
28984882-0	2017	Phosphoramidate hydrolysis catalyzed by human histidine triad nucleotide binding protein 1 (hHint1): a cluster-model DFT computational study.	phosphoramidic acid	0-15	histidine triad nucleotide binding protein 1	Homo sapiens	46-90
28984882-0	2017	Phosphoramidate hydrolysis catalyzed by human histidine triad nucleotide binding protein 1 (hHint1): a cluster-model DFT computational study.	phosphoramidic acid	0-15	histidine triad nucleotide binding protein 1	Homo sapiens	92-98
28984882-1	2017	As a member of the histidine triad (HIT) protein superfamily, human histidine triad nucleotide binding protein 1 (hHint1) serves as an efficient enzyme in the hydrolysis of phosphoramidate.	Histidine	19-28	histidine triad nucleotide binding protein 1	Homo sapiens	68-112
28984882-1	2017	As a member of the histidine triad (HIT) protein superfamily, human histidine triad nucleotide binding protein 1 (hHint1) serves as an efficient enzyme in the hydrolysis of phosphoramidate.	Histidine	19-28	histidine triad nucleotide binding protein 1	Homo sapiens	114-120
28984882-1	2017	As a member of the histidine triad (HIT) protein superfamily, human histidine triad nucleotide binding protein 1 (hHint1) serves as an efficient enzyme in the hydrolysis of phosphoramidate.	phosphoramidic acid	173-188	histidine triad nucleotide binding protein 1	Homo sapiens	68-112
28984882-1	2017	As a member of the histidine triad (HIT) protein superfamily, human histidine triad nucleotide binding protein 1 (hHint1) serves as an efficient enzyme in the hydrolysis of phosphoramidate.	phosphoramidic acid	173-188	histidine triad nucleotide binding protein 1	Homo sapiens	114-120
28984882-2	2017	In particular, hHint1 has been utilized to activate nucleotide prodrugs (proTides).	protides	73-81	histidine triad nucleotide binding protein 1	Homo sapiens	15-21
28984882-3	2017	Understanding the mechanism of hHint1 will aid in the future design of proTides.	protides	71-79	histidine triad nucleotide binding protein 1	Homo sapiens	31-37
28739258-0	2017	Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.	Metals	23-28	histidine triad nucleotide binding protein 1	Homo sapiens	43-86
28739258-0	2017	Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.	Metals	23-28	histidine triad nucleotide binding protein 1	Homo sapiens	88-94
28739258-3	2017	The role of metal ions in regulating postsynaptic transmission is well known, and the active site of hHint1 contains multiple histidines.	Metals	12-17	histidine triad nucleotide binding protein 1	Homo sapiens	101-107
28739258-3	2017	The role of metal ions in regulating postsynaptic transmission is well known, and the active site of hHint1 contains multiple histidines.	Histidine	126-136	histidine triad nucleotide binding protein 1	Homo sapiens	101-107
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	Metals	49-54	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	cupric ion	67-71	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	magnesium ion	73-77	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	Manganese(2+)	79-83	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	Nickel(2+)	85-89	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	Zinc	95-99	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-5	2017	With the exception of Mg2+, all the divalent ions inhibited hHint1, the rank of order was found to be Cu2+ >Zn2+ >Cd2+ >=Ni2+ >Mn2+ based on their IC50 and kin/KI values.	magnesium ion	22-26	histidine triad nucleotide binding protein 1	Homo sapiens	60-66
28739258-5	2017	With the exception of Mg2+, all the divalent ions inhibited hHint1, the rank of order was found to be Cu2+ >Zn2+ >Cd2+ >=Ni2+ >Mn2+ based on their IC50 and kin/KI values.	cupric ion	102-106	histidine triad nucleotide binding protein 1	Homo sapiens	60-66
28739258-5	2017	With the exception of Mg2+, all the divalent ions inhibited hHint1, the rank of order was found to be Cu2+ >Zn2+ >Cd2+ >=Ni2+ >Mn2+ based on their IC50 and kin/KI values.	Zinc	111-115	histidine triad nucleotide binding protein 1	Homo sapiens	60-66
28739258-5	2017	With the exception of Mg2+, all the divalent ions inhibited hHint1, the rank of order was found to be Cu2+ >Zn2+ >Cd2+ >=Ni2+ >Mn2+ based on their IC50 and kin/KI values.	Nickel(2+)	130-134	histidine triad nucleotide binding protein 1	Homo sapiens	60-66
28739258-5	2017	With the exception of Mg2+, all the divalent ions inhibited hHint1, the rank of order was found to be Cu2+ >Zn2+ >Cd2+ >=Ni2+ >Mn2+ based on their IC50 and kin/KI values.	Manganese(2+)	139-143	histidine triad nucleotide binding protein 1	Homo sapiens	60-66
28739258-6	2017	A crystal structure of hHint1 with bound Cu2+ is described to explain the competitive reversible inactivation of hHint1 by divalent cations.	cupric ion	41-45	histidine triad nucleotide binding protein 1	Homo sapiens	23-29
28739258-6	2017	A crystal structure of hHint1 with bound Cu2+ is described to explain the competitive reversible inactivation of hHint1 by divalent cations.	cupric ion	41-45	histidine triad nucleotide binding protein 1	Homo sapiens	113-119
28739258-9	2017	Our studies reveal a loss in secondary structure and aggregation of hHint1 upon incubation with 10-fold excess of copper.	Copper	114-120	histidine triad nucleotide binding protein 1	Homo sapiens	68-74
28739258-10	2017	Thus, hHint1 appears to be structurally sensitive to irreversible inactivation by copper, which may be of neurotoxicological and pharmacological significance.	Copper	82-88	histidine triad nucleotide binding protein 1	Homo sapiens	6-12
28947944-2	2017	The proTide incorporates a chemically cleavable 2-(methylthio)ethyl moiety and a HINT1 hydrolyzable tryptamine phosphoramidate.	tryptamine phosphoramidate	100-126	histidine triad nucleotide binding protein 1	Homo sapiens	81-86
28947944-4	2017	Furthermore, we demonstrate with a HINT1 inhibitor that the anti DENV-2 activity of the proTide correlates with the activity of HINT1.	CHEBI:29300	88-95	histidine triad nucleotide binding protein 1	Homo sapiens	35-40
28947944-4	2017	Furthermore, we demonstrate with a HINT1 inhibitor that the anti DENV-2 activity of the proTide correlates with the activity of HINT1.	CHEBI:29300	88-95	histidine triad nucleotide binding protein 1	Homo sapiens	128-133
28947944-5	2017	Taken together, these results demonstrate that a phosphoramidate based pronucleotide that undergoes an initial nonenzymatic activation step based on anchimeric assistance followed by P-N bond cleavage by HINT1 can be prepared.	phosphoramidic acid	49-64	histidine triad nucleotide binding protein 1	Homo sapiens	204-209
28947944-5	2017	Taken together, these results demonstrate that a phosphoramidate based pronucleotide that undergoes an initial nonenzymatic activation step based on anchimeric assistance followed by P-N bond cleavage by HINT1 can be prepared.	pronucleotide	71-84	histidine triad nucleotide binding protein 1	Homo sapiens	204-209
28768489-12	2017	The newly predicted drug responses of GDSC dataset suggest that mTOR inhibitor rapamycin was sensitive to non-small cell lung cancer (NSCLC), and expression of AK1RC3 and HINT1 may be adjunct markers of cell line sensitivity to rapamycin.	Sirolimus	228-237	histidine triad nucleotide binding protein 1	Homo sapiens	171-176
29214080-2	2017	As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzymatic activity.	Histidine	19-28	histidine triad nucleotide binding protein 1	Homo sapiens	61-66
28691797-0	2017	Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).	Sofosbuvir	78-88	histidine triad nucleotide binding protein 1	Homo sapiens	114-158
28691797-0	2017	Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).	Sofosbuvir	78-88	histidine triad nucleotide binding protein 1	Homo sapiens	160-166
28691797-2	2017	Human Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides), such as the FDA approved hepatitis C drug, sofosbuvir.	pronucleotides	96-110	histidine triad nucleotide binding protein 1	Homo sapiens	6-11
28691797-2	2017	Human Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides), such as the FDA approved hepatitis C drug, sofosbuvir.	protides	118-126	histidine triad nucleotide binding protein 1	Homo sapiens	6-11
28691797-2	2017	Human Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides), such as the FDA approved hepatitis C drug, sofosbuvir.	Sofosbuvir	172-182	histidine triad nucleotide binding protein 1	Homo sapiens	6-11
28691797-3	2017	The active site of hHint1 comprises an ensemble of strictly conserved histidines, including nucleophilic His112.	Histidine	70-80	histidine triad nucleotide binding protein 1	Homo sapiens	19-25
28691797-4	2017	To structurally investigate the mechanism of hHint1 catalysis, we have designed and prepared nucleoside thiophosphoramidate substrates that are able to capture the transiently formed nucleotidylated-His112 intermediate (E*) using time-dependent crystallography.	nucleoside thiophosphoramidate	93-123	histidine triad nucleotide binding protein 1	Homo sapiens	45-51
28418378-0	2017	Polysaccharide structure: A hint from gut bacteria.	Polysaccharides	0-14	histidine triad nucleotide binding protein 1	Homo sapiens	28-32
28452756-4	2017	The data hint at a decreased electrostatic interaction at higher pressure, presumably due to the increase of the dielectric constant of water by 3% and the decrease of the free volume at 300 bar.	Water	136-141	histidine triad nucleotide binding protein 1	Homo sapiens	9-13
27563403-0	2016	Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.	fusarubin	43-52	histidine triad nucleotide binding protein 1	Homo sapiens	99-105
27323834-7	2016	Subsequently, the calcium-regulated HINT1/sigma1R protein tandem uncouples CB1Rs to prevent NMDAR hypofunction.	Calcium	18-25	histidine triad nucleotide binding protein 1	Homo sapiens	36-41
27783069-4	2016	Occasional excursions to a non-fluorescent cis-state hint at the remarkable sensitivity of carbocyanines to their local environment.	Carbocyanines	91-104	histidine triad nucleotide binding protein 1	Homo sapiens	53-57
27563403-0	2016	Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.	sulfamic acid	57-66	histidine triad nucleotide binding protein 1	Homo sapiens	99-105
27563403-1	2016	Hint1 has recently emerged to be an important target of interest due to its involvement in the regulation of a broad range of CNS functions including opioid signaling, tolerance, neuropathic pain, and nicotine dependence.	Nicotine	201-209	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
26551102-0	2015	Scalar Hint from the Diboson Excess?	diboson	21-28	histidine triad nucleotide binding protein 1	Homo sapiens	7-11
26905466-3	2016	Here, we report the first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal.	Polyphosphates	198-211	histidine triad nucleotide binding protein 1	Homo sapiens	82-87
27144453-10	2016	Potential mechanisms for gene regulation mediated by Ap4A and/or NUDT2 disruption include binding of Ap4A to the HINT1 co-repressor, autocrine activation of purinoceptors by Ap4A, chromatin remodeling, effects of NUDT2 loss on transcript stability, and inhibition of ATP-dependent regulatory factors such as protein kinases by Ap4A.	Adenosine Triphosphate	267-270	histidine triad nucleotide binding protein 1	Homo sapiens	113-118
26905466-3	2016	Here, we report the first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal.	ap4a dinucleotide	125-142	histidine triad nucleotide binding protein 1	Homo sapiens	82-87
26905466-3	2016	Here, we report the first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal.	bis-phosphorothioated	155-176	histidine triad nucleotide binding protein 1	Homo sapiens	82-87
26905466-3	2016	Here, we report the first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal.	Glycerol	177-185	histidine triad nucleotide binding protein 1	Homo sapiens	82-87
26816264-0	2016	Design, Synthesis, and Proticity Inclined Conformational Modulation in a Highly Fluorescent Bichromophoric Naphthalimide Derivative: Hint Directed from RICT Perspective.	Naphthalimides	107-120	histidine triad nucleotide binding protein 1	Homo sapiens	133-137
26820384-4	2016	In spite of the hydrophobic character of the teicoplanin precursor, the polar active site of OxyAtei and its affinity for certain azole inhibitors hint at its preference for substrates with polar decorations.	Teicoplanin	45-56	histidine triad nucleotide binding protein 1	Homo sapiens	147-151
26820384-4	2016	In spite of the hydrophobic character of the teicoplanin precursor, the polar active site of OxyAtei and its affinity for certain azole inhibitors hint at its preference for substrates with polar decorations.	Azoles	130-135	histidine triad nucleotide binding protein 1	Homo sapiens	147-151
25976113-3	2016	In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1).	Histidine	114-123	histidine triad nucleotide binding protein 1	Homo sapiens	183-215
26750483-5	2016	Here, the structure of HINT from Helicobacter pylori (HpHINT) in complex with AMP is reported at a resolution of 3 A.	Adenosine Monophosphate	78-81	histidine triad nucleotide binding protein 1	Homo sapiens	23-27
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	85-94	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
26431005-4	2015	Although the exact mechanism of this fourfold periodicity in dephasing rates is an open problem, our observations hint at the fourfold degeneracy expected in graphene from its spin and valley degrees of freedom.	Graphite	158-166	histidine triad nucleotide binding protein 1	Homo sapiens	114-118
27092011-3	2015	The findings hint that the air-water interface is a locale for synthetic reactions.	Water	31-36	histidine triad nucleotide binding protein 1	Homo sapiens	13-17
25993345-14	2015	Significantly, reports concerning late transition metal systems have appeared that hint at the generality of the WALPI concept for modulating polymerization reactions.	Metals	50-55	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
25826698-7	2015	Among other HIT proteins, human histidine triad nucleotide-binding protein (Hint1) catalysed fluorolysis of NH2-pA 20 times and human Hint2 40 times more slowly than human Fhit.	nh2-pa	108-114	histidine triad nucleotide binding protein 1	Homo sapiens	76-81
25199874-0	2014	Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5"-O-monophosphorothioate and their derivatives - Implication for desulfuration process in the cell.	nucleosides 5"-o-monophosphorothioate	75-112	histidine triad nucleotide binding protein 1	Homo sapiens	25-69
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	nucleoside 5"-o-phosphorothioate	137-169	histidine triad nucleotide binding protein 1	Homo sapiens	37-81
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	nucleoside 5"-o-phosphorothioate	137-169	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	N-methylpyrrolidone	171-175	histidine triad nucleotide binding protein 1	Homo sapiens	37-81
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	N-methylpyrrolidone	171-175	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	5"-o-phosphate	184-198	histidine triad nucleotide binding protein 1	Homo sapiens	37-81
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	5"-o-phosphate	184-198	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	N-methylpyrrolidone	171-174	histidine triad nucleotide binding protein 1	Homo sapiens	37-81
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	N-methylpyrrolidone	171-174	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	Hydrogen Sulfide	245-261	histidine triad nucleotide binding protein 1	Homo sapiens	37-81
25199874-1	2014	BACKGROUND: One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5"-O-phosphorothioate (NMPS) to its 5"-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.	Hydrogen Sulfide	245-261	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
25199874-2	2014	METHODS: Non-hydrolyzable derivatives of AMPS and dCMPS, each containing the residue able to form a covalent bond in nucleic acid-protein complexes via photocrosslinking (at 308nm), were applied at the complexing experiments with recombinant and cellular Hint1.	Deoxycytidine Monophosphate	50-55	histidine triad nucleotide binding protein 1	Homo sapiens	255-260
25199874-7	2014	CONCLUSIONS: The enzymatic conversion of AMPS to AMP occurred with the participation of cellular Hint1, the protein, which is present in all organisms.	Adenosine Monophosphate	41-44	histidine triad nucleotide binding protein 1	Homo sapiens	97-102
25199874-8	2014	GENERAL SIGNIFICANCE: The intracellular Hint1 could be responsible for the in vivo desulfuration of nucleosides-5"-monophosphorothioate, thus it can contribute to the phosphorothioate oligonucleotides metabolism.	nucleosides-5"-monophosphorothioate	100-135	histidine triad nucleotide binding protein 1	Homo sapiens	40-45
25199874-8	2014	GENERAL SIGNIFICANCE: The intracellular Hint1 could be responsible for the in vivo desulfuration of nucleosides-5"-monophosphorothioate, thus it can contribute to the phosphorothioate oligonucleotides metabolism.	Phosphorothioate Oligonucleotides	167-200	histidine triad nucleotide binding protein 1	Homo sapiens	40-45
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	85-94	histidine triad nucleotide binding protein 1	Homo sapiens	46-51
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	158-167	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	158-167	histidine triad nucleotide binding protein 1	Homo sapiens	46-51
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	x-histidine-x-histidine	168-191	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	x-histidine-x-histidine	168-191	histidine triad nucleotide binding protein 1	Homo sapiens	46-51
24076743-6	2013	In particular, a detailed analysis of water molecules at the interfaces of high-resolution (<=2.30 A) X-ray crystal structures of protein-protein complexes, where 140 are biological protein-protein complex structures and 112 include non-biological protein-protein interfaces, was carried out using modeling tools based on the HINT forcefield.	Water	38-43	histidine triad nucleotide binding protein 1	Homo sapiens	329-333
23666425-8	2013	This NO acts on the RGSZ2 zinc finger, providing the zinc ions that are required for PKC/Raf-1 cysteine-rich domains to simultaneously bind to the histidines present in the HINT1 homodimer.	Cysteine	95-103	histidine triad nucleotide binding protein 1	Homo sapiens	173-178
21975791-13	2011	AUTHORS" CONCLUSIONS: These three studies no more than hint that sodium valproate may reduce pain in diabetic neuropathy, and divalproex sodium in post-herpetic neuralgia, but the use of "completer" analysis may overestimate efficacy, and there were too few data for pooled analysis of efficacy or harm, or to have confidence in the results of the individual studies.	Valproic Acid	65-81	histidine triad nucleotide binding protein 1	Homo sapiens	55-59
23934318-0	2013	Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats.	Carbon Tetrachloride	100-120	histidine triad nucleotide binding protein 1	Homo sapiens	18-62
23934318-4	2013	Thus, we sought to investigate whether the recombinant human Hint1 protein (rhHint1) was capable of attenuating liver fibrosis induced by carbon tetrachloride (CCl4) in rats and the possible underlying mechanism(s) of action.	Carbon Tetrachloride	138-158	histidine triad nucleotide binding protein 1	Homo sapiens	61-66
24042168-6	2013	Through mapping with those published cases using the same a-CGH method, the CDR was reduced from 29 Mb to 6 Mb, which excluded the previous candidate genes and highlighted an excellent biological gene: the HINT1 gene.	cdr	76-79	histidine triad nucleotide binding protein 1	Homo sapiens	206-211
23614568-2	2013	hHint1 is a homodimeric protein that catalyzes the hydrolysis of model substrates, phosphoramidate and acyl adenylate, with a high efficiency.	phosphoramidic acid	83-98	histidine triad nucleotide binding protein 1	Homo sapiens	0-6
23614568-2	2013	hHint1 is a homodimeric protein that catalyzes the hydrolysis of model substrates, phosphoramidate and acyl adenylate, with a high efficiency.	acyl adenylate	103-117	histidine triad nucleotide binding protein 1	Homo sapiens	0-6
23614568-3	2013	Recently, catalytically inactive hHint1 has been identified as the cause of inherited peripheral neuropathy [Zimon, M., et al.	zimon	109-114	histidine triad nucleotide binding protein 1	Homo sapiens	33-39
23614568-7	2013	We have conducted the first detailed kinetic mechanistic studies of hHint1 and have found that the reaction mechanism is consistent with a double-displacement mechanism, in which the active site nucleophile His112 is first adenylylated by the substrate, followed by hydrolysis of the AMP-enzyme intermediate.	Adenosine Monophosphate	284-287	histidine triad nucleotide binding protein 1	Homo sapiens	68-74
23614568-13	2013	In comparison to the uncatalyzed rates, hHint1 was shown to enhance acyl-AMP and AMP phosphoramidate hydrolysis by 10(6)-10(8)-fold.	acyl-amp	68-76	histidine triad nucleotide binding protein 1	Homo sapiens	40-46
23614568-13	2013	In comparison to the uncatalyzed rates, hHint1 was shown to enhance acyl-AMP and AMP phosphoramidate hydrolysis by 10(6)-10(8)-fold.	Angiopep-2	81-100	histidine triad nucleotide binding protein 1	Homo sapiens	40-46
23614568-14	2013	Taken together, our analysis indicates that hHint1 catalyzes the hydrolysis of phosphoramidate and acyl adenylate with high efficiency, through a mechanism that relies on rapid adenylylation of the active residue, His112, while being partially rate-limited by intermediate hydrolysis and product release associated with a conformational change.	phosphoramidic acid	79-94	histidine triad nucleotide binding protein 1	Homo sapiens	44-50
23614568-14	2013	Taken together, our analysis indicates that hHint1 catalyzes the hydrolysis of phosphoramidate and acyl adenylate with high efficiency, through a mechanism that relies on rapid adenylylation of the active residue, His112, while being partially rate-limited by intermediate hydrolysis and product release associated with a conformational change.	acyl adenylate	99-113	histidine triad nucleotide binding protein 1	Homo sapiens	44-50
23289910-6	2013	Recently, we have prepared a tryptamine phosphoramidate prodrug of 7Bn-GMP, 4Ei-1, and shown that it is a substrate for human histidine triad nucleotide binding protein (hHINT1) and inhibits eIF4E initiated epithelial-mesenchymal transition (EMT) by Zebra fish embryo cells.	tryptamine phosphoramidate	29-55	histidine triad nucleotide binding protein 1	Homo sapiens	170-176
24860707-0	2013	Tandem mass spectrometry of nitric oxide and hydrogen sulfide releasing aspirins: a hint into activity behavior.	Nitric Oxide	28-40	histidine triad nucleotide binding protein 1	Homo sapiens	84-88
24860707-0	2013	Tandem mass spectrometry of nitric oxide and hydrogen sulfide releasing aspirins: a hint into activity behavior.	Aspirin	72-80	histidine triad nucleotide binding protein 1	Homo sapiens	84-88
22329685-2	2012	Hint1 activity is connected to lysyl-tRNA synthetase (LysRS), a member of the universal aminoacyl tRNA synthetase family that catalyzes specific aminoacylation of their cognate tRNAs, through an aminoacyl adenylate (aa-AMP) intermediate.	aminoacyl adenylate	195-214	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
23666425-8	2013	This NO acts on the RGSZ2 zinc finger, providing the zinc ions that are required for PKC/Raf-1 cysteine-rich domains to simultaneously bind to the histidines present in the HINT1 homodimer.	Histidine	147-157	histidine triad nucleotide binding protein 1	Homo sapiens	173-178
24093505-6	2013	RESULTS: We found that in the presence of GPCRs, the HINT1 protein influences the activity of NMDARs, whereby NMDAR activation was enhanced in CNR1+/+/HINT1-/- cortical neurons and the cannabinoid agonist WIN55,212-2 provided these cells with no protection against a NMDA insult.	N-Methylaspartate	94-98	histidine triad nucleotide binding protein 1	Homo sapiens	53-58
24093505-6	2013	RESULTS: We found that in the presence of GPCRs, the HINT1 protein influences the activity of NMDARs, whereby NMDAR activation was enhanced in CNR1+/+/HINT1-/- cortical neurons and the cannabinoid agonist WIN55,212-2 provided these cells with no protection against a NMDA insult.	N-Methylaspartate	94-98	histidine triad nucleotide binding protein 1	Homo sapiens	151-156
22869114-0	2012	A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5"-monophosphate at 1.38 A resolution.	adenosine 5"-monophosphate	98-124	histidine triad nucleotide binding protein 1	Homo sapiens	28-72
22869114-0	2012	A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5"-monophosphate at 1.38 A resolution.	adenosine 5"-monophosphate	98-124	histidine triad nucleotide binding protein 1	Homo sapiens	74-80
22869114-3	2012	Here, the structure of the human HINT1-adenosine 5"-monophosphate (AMP) complex at 1.38 A resolution obtained from a new monoclinic crystal form is reported.	Adenosine Monophosphate	67-70	histidine triad nucleotide binding protein 1	Homo sapiens	33-38
22329685-2	2012	Hint1 activity is connected to lysyl-tRNA synthetase (LysRS), a member of the universal aminoacyl tRNA synthetase family that catalyzes specific aminoacylation of their cognate tRNAs, through an aminoacyl adenylate (aa-AMP) intermediate.	aa-amp	216-222	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
22329685-5	2012	Earlier work showed that Hint1 can also bind and hydrolyze Lys-AMP, possibly to constrain Ap(4)A production.	Lisdexamfetamine dimesylate	59-66	histidine triad nucleotide binding protein 1	Homo sapiens	25-30
22329685-5	2012	Earlier work showed that Hint1 can also bind and hydrolyze Lys-AMP, possibly to constrain Ap(4)A production.	diadenosine tetraphosphate	90-96	histidine triad nucleotide binding protein 1	Homo sapiens	25-30
22329685-6	2012	Because Ap(4)A can result from condensation of other aa-AMP"s with ATP, the specificity of the Hint1 aa-AMP-hydrolysis activity is of interest.	diadenosine tetraphosphate	8-14	histidine triad nucleotide binding protein 1	Homo sapiens	95-100
22329685-6	2012	Because Ap(4)A can result from condensation of other aa-AMP"s with ATP, the specificity of the Hint1 aa-AMP-hydrolysis activity is of interest.	aa-amp	53-59	histidine triad nucleotide binding protein 1	Homo sapiens	95-100
22329685-6	2012	Because Ap(4)A can result from condensation of other aa-AMP"s with ATP, the specificity of the Hint1 aa-AMP-hydrolysis activity is of interest.	Adenosine Triphosphate	67-70	histidine triad nucleotide binding protein 1	Homo sapiens	95-100
22329685-6	2012	Because Ap(4)A can result from condensation of other aa-AMP"s with ATP, the specificity of the Hint1 aa-AMP-hydrolysis activity is of interest.	Adenosine Monophosphate	56-59	histidine triad nucleotide binding protein 1	Homo sapiens	95-100
22329685-7	2012	Here we show that Hint1 has broad specificity for adenylate hydrolysis, whose structural basis we revealed through high-resolution structures of Hint1 in complex with three different aa-AMP analogues.	aa-amp	183-189	histidine triad nucleotide binding protein 1	Homo sapiens	18-23
22329685-7	2012	Here we show that Hint1 has broad specificity for adenylate hydrolysis, whose structural basis we revealed through high-resolution structures of Hint1 in complex with three different aa-AMP analogues.	aa-amp	183-189	histidine triad nucleotide binding protein 1	Homo sapiens	145-150
22329685-8	2012	Hint1 recognizes only the common main chain of the aminoacyl moiety, and has no contact with the aa side chain.	aminoacyl	51-60	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
22329685-10	2012	These results reveal the structural basis for the remarkable adenylate surveillance activity of Hint1, to potentially control Ap(4)A levels in the cell.	diadenosine tetraphosphate	126-132	histidine triad nucleotide binding protein 1	Homo sapiens	96-101
22104145-1	2012	Based on recent substrate specificity studies, a series of ribonucleotide based esters and carbamates were synthesized and screened as inhibitors of the phosphoramidases and acyl-AMP hydrolases, Escherichia coli Histidine Triad Nucleotide Binding Protein (ecHinT) and human Histidine Triad Nucleotide Binding Protein 1 (hHint1).	ribonucleotide based esters	59-86	histidine triad nucleotide binding protein 1	Homo sapiens	274-318
22104145-1	2012	Based on recent substrate specificity studies, a series of ribonucleotide based esters and carbamates were synthesized and screened as inhibitors of the phosphoramidases and acyl-AMP hydrolases, Escherichia coli Histidine Triad Nucleotide Binding Protein (ecHinT) and human Histidine Triad Nucleotide Binding Protein 1 (hHint1).	ribonucleotide based esters	59-86	histidine triad nucleotide binding protein 1	Homo sapiens	320-326
22104145-4	2012	The carbamate based inhibitors were shown to successfully suppress the Hint1-associated phenotype in E. coli, suggesting that they are permeable intracellular inhibitors of ecHinT.	Carbamates	4-13	histidine triad nucleotide binding protein 1	Homo sapiens	71-76
22052020-2	2011	Direct molecular dynamics simulations of (quasi) single crystalline super cell models hint at the preferred mobility mechanism which is based on fluoride interstitial (and to a smaller extent F(-) vacancy) migration.	Fluorides	145-153	histidine triad nucleotide binding protein 1	Homo sapiens	86-90
21843332-0	2011	Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohistological study.	Diphosphonates	69-83	histidine triad nucleotide binding protein 1	Homo sapiens	33-37
20940308-4	2010	An additional, but usually ignored, activity of Hint-1 is its ability to catalyze the conversion of adenosine 5"-O-monophosphorothioate (AMPS) to 5"-O-monophosphate (AMP).	adenosine 5"-o-monophosphorothioate	100-135	histidine triad nucleotide binding protein 1	Homo sapiens	48-54
21600932-6	2011	Histidine triad nucleotide-binding protein 1 (Hint 1) then removes the amino acid moiety, which is followed by hydrolysis of the methoxyl group at the O(6)-position of the guanine base by adenosine deaminase-like protein 1 (ADAL1) to give 2"-deoxy-2"-fluoro-2"-C-methylguanosine-5"-monophosphate.	Guanine	172-179	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
21600932-6	2011	Histidine triad nucleotide-binding protein 1 (Hint 1) then removes the amino acid moiety, which is followed by hydrolysis of the methoxyl group at the O(6)-position of the guanine base by adenosine deaminase-like protein 1 (ADAL1) to give 2"-deoxy-2"-fluoro-2"-C-methylguanosine-5"-monophosphate.	Guanine	172-179	histidine triad nucleotide binding protein 1	Homo sapiens	46-52
21600932-6	2011	Histidine triad nucleotide-binding protein 1 (Hint 1) then removes the amino acid moiety, which is followed by hydrolysis of the methoxyl group at the O(6)-position of the guanine base by adenosine deaminase-like protein 1 (ADAL1) to give 2"-deoxy-2"-fluoro-2"-C-methylguanosine-5"-monophosphate.	2"-deoxy-2"-fluoro-2"-c-methylguanosine-5"-monophosphate	239-295	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
21600932-6	2011	Histidine triad nucleotide-binding protein 1 (Hint 1) then removes the amino acid moiety, which is followed by hydrolysis of the methoxyl group at the O(6)-position of the guanine base by adenosine deaminase-like protein 1 (ADAL1) to give 2"-deoxy-2"-fluoro-2"-C-methylguanosine-5"-monophosphate.	2"-deoxy-2"-fluoro-2"-c-methylguanosine-5"-monophosphate	239-295	histidine triad nucleotide binding protein 1	Homo sapiens	46-52
21383096-7	2011	The cPrPMEDAP-L-phenylalanine conjugate (cPrPMEDAP-Phe) formed is not metabolized by Hint1 (histidine triad nucleotide binding protein 1) phosphoramidase but undergoes spontaneous degradation to cPrPMEDAP in acidic pH that can be significantly enhanced by the addition of SiHa cell extract.	cprpmedap-l-phenylalanine	4-29	histidine triad nucleotide binding protein 1	Homo sapiens	92-136
21383096-7	2011	The cPrPMEDAP-L-phenylalanine conjugate (cPrPMEDAP-Phe) formed is not metabolized by Hint1 (histidine triad nucleotide binding protein 1) phosphoramidase but undergoes spontaneous degradation to cPrPMEDAP in acidic pH that can be significantly enhanced by the addition of SiHa cell extract.	cprpmedap-phe	41-54	histidine triad nucleotide binding protein 1	Homo sapiens	92-136
21383096-7	2011	The cPrPMEDAP-L-phenylalanine conjugate (cPrPMEDAP-Phe) formed is not metabolized by Hint1 (histidine triad nucleotide binding protein 1) phosphoramidase but undergoes spontaneous degradation to cPrPMEDAP in acidic pH that can be significantly enhanced by the addition of SiHa cell extract.	N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine	4-13	histidine triad nucleotide binding protein 1	Homo sapiens	92-136
20940308-0	2010	Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5"-O-phosphorothioates to nucleoside 5"-O-phosphates.	nucleoside 5"-o-phosphorothioates	81-114	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
20940308-0	2010	Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5"-O-phosphorothioates to nucleoside 5"-O-phosphates.	nucleoside 5"-o-phosphorothioates	81-114	histidine triad nucleotide binding protein 1	Homo sapiens	46-52
20940308-0	2010	Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5"-O-phosphorothioates to nucleoside 5"-O-phosphates.	nucleoside 5"-o-phosphates	118-144	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
20940308-0	2010	Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5"-O-phosphorothioates to nucleoside 5"-O-phosphates.	nucleoside 5"-o-phosphates	118-144	histidine triad nucleotide binding protein 1	Homo sapiens	46-52
20514075-0	2011	Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence.	Nicotine	91-99	histidine triad nucleotide binding protein 1	Homo sapiens	19-63
20514075-0	2011	Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence.	Nicotine	91-99	histidine triad nucleotide binding protein 1	Homo sapiens	65-70
20514075-1	2011	The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine.	Morphine	126-134	histidine triad nucleotide binding protein 1	Homo sapiens	4-48
20514075-1	2011	The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine.	Morphine	126-134	histidine triad nucleotide binding protein 1	Homo sapiens	55-60
20514075-1	2011	The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine.	Amphetamine	139-150	histidine triad nucleotide binding protein 1	Homo sapiens	4-48
20514075-1	2011	The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine.	Amphetamine	139-150	histidine triad nucleotide binding protein 1	Homo sapiens	55-60
20514075-7	2011	These results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking.	Nicotine	94-102	histidine triad nucleotide binding protein 1	Homo sapiens	53-58
20514075-7	2011	These results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking.	Nicotine	94-102	histidine triad nucleotide binding protein 1	Homo sapiens	125-130
21235400-6	2011	The zinc ions bridge the Raf-1 cysteine-rich domain (CRD) with HINT1 at the MOR C-terminus.	Cysteine	31-39	histidine triad nucleotide binding protein 1	Homo sapiens	63-68
21235400-7	2011	Morphine also recruits PKCgamma via NO/zinc to the MOR-HINT1 complex.	Morphine	0-8	histidine triad nucleotide binding protein 1	Homo sapiens	55-60
21235400-9	2011	Thus, through attached HINT1, the MOR facilitates the cross-talk of two NO- and zinc-regulated signal-transduction pathways, PKC/Src and Raf-1/ERK1/2, implicated in the negative control of morphine effects.	Morphine	189-197	histidine triad nucleotide binding protein 1	Homo sapiens	23-28
21468541-8	2011	We treated AGS cells, a GC cell line with low expression level of Hint1, with 5 and 10 micromol/l 5-Aza-dC for 72 h and found that HINT1 could be induced by 5-Aza-dC in a dose-dependent manner.	Azacitidine	98-103	histidine triad nucleotide binding protein 1	Homo sapiens	66-71
21468541-8	2011	We treated AGS cells, a GC cell line with low expression level of Hint1, with 5 and 10 micromol/l 5-Aza-dC for 72 h and found that HINT1 could be induced by 5-Aza-dC in a dose-dependent manner.	Azacitidine	98-103	histidine triad nucleotide binding protein 1	Homo sapiens	131-136
21468541-8	2011	We treated AGS cells, a GC cell line with low expression level of Hint1, with 5 and 10 micromol/l 5-Aza-dC for 72 h and found that HINT1 could be induced by 5-Aza-dC in a dose-dependent manner.	Azacitidine	157-162	histidine triad nucleotide binding protein 1	Homo sapiens	66-71
21468541-8	2011	We treated AGS cells, a GC cell line with low expression level of Hint1, with 5 and 10 micromol/l 5-Aza-dC for 72 h and found that HINT1 could be induced by 5-Aza-dC in a dose-dependent manner.	Azacitidine	157-162	histidine triad nucleotide binding protein 1	Homo sapiens	131-136
20940308-3	2010	We suggest that the enzyme responsible for nucleoside 5"-O-monophosphorothioate ((d)NMPS) metabolism could be histidine triad nucleotide-binding protein 1 (Hint-1), a phosphoramidase belonging to the histidine triad (HIT) superfamily that is present in all forms of life.	nucleoside 5"-o-monophosphorothioate	43-79	histidine triad nucleotide binding protein 1	Homo sapiens	110-154
20940308-3	2010	We suggest that the enzyme responsible for nucleoside 5"-O-monophosphorothioate ((d)NMPS) metabolism could be histidine triad nucleotide-binding protein 1 (Hint-1), a phosphoramidase belonging to the histidine triad (HIT) superfamily that is present in all forms of life.	nucleoside 5"-o-monophosphorothioate	43-79	histidine triad nucleotide binding protein 1	Homo sapiens	156-162
20940308-3	2010	We suggest that the enzyme responsible for nucleoside 5"-O-monophosphorothioate ((d)NMPS) metabolism could be histidine triad nucleotide-binding protein 1 (Hint-1), a phosphoramidase belonging to the histidine triad (HIT) superfamily that is present in all forms of life.	Histidine	110-119	histidine triad nucleotide binding protein 1	Homo sapiens	156-162
20940308-4	2010	An additional, but usually ignored, activity of Hint-1 is its ability to catalyze the conversion of adenosine 5"-O-monophosphorothioate (AMPS) to 5"-O-monophosphate (AMP).	Adenylyl sulfate	137-141	histidine triad nucleotide binding protein 1	Homo sapiens	48-54
20940308-4	2010	An additional, but usually ignored, activity of Hint-1 is its ability to catalyze the conversion of adenosine 5"-O-monophosphorothioate (AMPS) to 5"-O-monophosphate (AMP).	5"-o-monophosphate	146-164	histidine triad nucleotide binding protein 1	Homo sapiens	48-54
20940308-4	2010	An additional, but usually ignored, activity of Hint-1 is its ability to catalyze the conversion of adenosine 5"-O-monophosphorothioate (AMPS) to 5"-O-monophosphate (AMP).	Adenosine Monophosphate	137-140	histidine triad nucleotide binding protein 1	Homo sapiens	48-54
20940308-6	2010	Additionally, crystallographic analysis (resolution from 1.08 to 1.37 A) of three engineered cysteine mutants showed the high similarity of their structures, which were not very different from the structure of WT Hint-1.	Cysteine	93-101	histidine triad nucleotide binding protein 1	Homo sapiens	213-219
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	Adenylyl sulfate	33-37	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	Ribonucleosides	53-67	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	2"-deoxyribonucleoside phosphorothioates	72-112	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	Adenylyl sulfate	183-187	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	2'-deoxyguanosine 5'-phosphate	193-198	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	Deoxycytidine Monophosphate	240-245	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	6-methylprednisolone-21-hemisuberate N,N,N'-triethylenediamine amide	251-255	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20940308-7	2010	Moreover, we found that not only AMPS but also other ribonucleoside and 2"-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS >= CMPS > UMPS > dAMPS >> dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released.	Hydrogen Sulfide	282-298	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
20934431-5	2010	Here we report the first conformational information on the full-length N-terminal and C-terminal residues of Hint from the E. coli complex with GMP.	guanosine 5'-monophosphorothioate	144-147	histidine triad nucleotide binding protein 1	Homo sapiens	109-113
20351114-9	2010	These findings hint at a link between copper and male fertility, which might also explain the high Ctr1 expression in mature mammalian spermatozoa.	Copper	38-44	histidine triad nucleotide binding protein 1	Homo sapiens	15-19
20801890-9	2010	The removal of the amino acid moiety of PSI-352707 is catalyzed by histidine triad nucleotide-binding protein 1 (Hint1) to give the 5"-monophosphate form, PSI-7411.	5"-monophosphate	132-148	histidine triad nucleotide binding protein 1	Homo sapiens	67-111
20801890-9	2010	The removal of the amino acid moiety of PSI-352707 is catalyzed by histidine triad nucleotide-binding protein 1 (Hint1) to give the 5"-monophosphate form, PSI-7411.	5"-monophosphate	132-148	histidine triad nucleotide binding protein 1	Homo sapiens	113-118
20585660-3	2010	In response to morphine, this HINT1-RGSZ complex binds PKCgamma, and afterwards, the interplay between PKCgamma, Src and Gz/Gi proteins leads to sustained potentiation of NMDAR-mediated glutamate responses.	Morphine	15-23	histidine triad nucleotide binding protein 1	Homo sapiens	30-35
20585660-3	2010	In response to morphine, this HINT1-RGSZ complex binds PKCgamma, and afterwards, the interplay between PKCgamma, Src and Gz/Gi proteins leads to sustained potentiation of NMDAR-mediated glutamate responses.	Glutamic Acid	186-195	histidine triad nucleotide binding protein 1	Homo sapiens	30-35
19089909-3	2009	In Hep3B and HepG2 cells, but not in Huh7 cells, the promoter region of Hint1 is partially methylated and treatment with 5-azadcdeoxycytidine increased expression of the HINT1 protein and Hint1 mRNA in Hep3B and HepG2 cells.	5-azadcdeoxycytidine	121-141	histidine triad nucleotide binding protein 1	Homo sapiens	72-77
20299228-5	2010	The results showed carboxypeptidase Y, hog liver esterase and crude CEM tumor cell extracts to hydrolyse the ester motif of phosphoramidates with subsequent loss of the aryl group, while molecular modelling studies suggested that the AraU l-alanine aminoacyl phosphate derivative might not be a good substrate for the phosphoramidase enzyme Hint-1.	phosphoramidic acid	124-140	histidine triad nucleotide binding protein 1	Homo sapiens	341-347
20299228-5	2010	The results showed carboxypeptidase Y, hog liver esterase and crude CEM tumor cell extracts to hydrolyse the ester motif of phosphoramidates with subsequent loss of the aryl group, while molecular modelling studies suggested that the AraU l-alanine aminoacyl phosphate derivative might not be a good substrate for the phosphoramidase enzyme Hint-1.	l-alanine aminoacyl phosphate	239-268	histidine triad nucleotide binding protein 1	Homo sapiens	341-347
20499681-2	2010	Hint1 catalyses the process of hydrolysis of the P-N bond in AMP-lysine, AMP-alanine, AMP-NH2.	Adenosine Monophosphate	61-64	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
20499681-2	2010	Hint1 catalyses the process of hydrolysis of the P-N bond in AMP-lysine, AMP-alanine, AMP-NH2.	Lysine	65-71	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
20499681-2	2010	Hint1 catalyses the process of hydrolysis of the P-N bond in AMP-lysine, AMP-alanine, AMP-NH2.	amp-alanine	73-84	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
20499681-2	2010	Hint1 catalyses the process of hydrolysis of the P-N bond in AMP-lysine, AMP-alanine, AMP-NH2.	adenosine 5'-phosphoramidate	86-93	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
19825512-2	2009	Although, inefficient compared to ribonucleotide based phosphoramidates, hHint 1 was identified as the likely intracellular pronucleotide activating enzyme.	pronucleotide	124-137	histidine triad nucleotide binding protein 1	Homo sapiens	73-80
19720079-1	2010	Histidine triad nucleotide binding protein (HINT) represents the most ancient and widespread branches in the histidine triad superfamily.	Histidine	109-118	histidine triad nucleotide binding protein 1	Homo sapiens	44-48
19720079-4	2010	Here we identified a HINT homologue in abalone, which we named ab-HINT.	abalone	39-46	histidine triad nucleotide binding protein 1	Homo sapiens	21-25
19720079-4	2010	Here we identified a HINT homologue in abalone, which we named ab-HINT.	abalone	39-46	histidine triad nucleotide binding protein 1	Homo sapiens	66-70
19720079-6	2010	RT-PCR and western blot analysis show that ab-HINT is ubiquitously expressed in abalone tissues and highly expressed in hemocyte and gills.	abalone	80-87	histidine triad nucleotide binding protein 1	Homo sapiens	46-50
19720079-10	2010	These results conclude that ab-HINT is involved in the immune response of abalone and may be a potential pro-apoptotic factor.	abalone	74-81	histidine triad nucleotide binding protein 1	Homo sapiens	31-35
19545154-5	2009	Eleven hormetic response proteins (HINT1, PHB, CTSD, ANXA1, LGASL1, TPT1, NPM, PRDX2, UCHL1, CERK, and C1QBP) were involved in 5 death-regulatory pathways, including the p53-dependent apoptotic pathway, protein ubiquinization, cellular redox, calcium-mediated signaling pathway, and sphingomyelin-metabolism pathway.	Calcium	243-250	histidine triad nucleotide binding protein 1	Homo sapiens	35-40
19545154-5	2009	Eleven hormetic response proteins (HINT1, PHB, CTSD, ANXA1, LGASL1, TPT1, NPM, PRDX2, UCHL1, CERK, and C1QBP) were involved in 5 death-regulatory pathways, including the p53-dependent apoptotic pathway, protein ubiquinization, cellular redox, calcium-mediated signaling pathway, and sphingomyelin-metabolism pathway.	Sphingomyelins	283-296	histidine triad nucleotide binding protein 1	Homo sapiens	35-40
19089909-3	2009	In Hep3B and HepG2 cells, but not in Huh7 cells, the promoter region of Hint1 is partially methylated and treatment with 5-azadcdeoxycytidine increased expression of the HINT1 protein and Hint1 mRNA in Hep3B and HepG2 cells.	5-azadcdeoxycytidine	121-141	histidine triad nucleotide binding protein 1	Homo sapiens	170-175
19089909-3	2009	In Hep3B and HepG2 cells, but not in Huh7 cells, the promoter region of Hint1 is partially methylated and treatment with 5-azadcdeoxycytidine increased expression of the HINT1 protein and Hint1 mRNA in Hep3B and HepG2 cells.	5-azadcdeoxycytidine	121-141	histidine triad nucleotide binding protein 1	Homo sapiens	188-193
18923405-7	2009	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	gamma-Aminobutyric Acid	64-68	histidine triad nucleotide binding protein 1	Homo sapiens	118-123
19081673-1	2009	The Hint1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues.	Histidine	35-44	histidine triad nucleotide binding protein 1	Homo sapiens	4-9
17337452-0	2007	Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.	lysyladenylate	146-161	histidine triad nucleotide binding protein 1	Homo sapiens	27-71
19022511-2	2009	The promising anticancer clinical candidates salinosporamide A and bryostatin only hint at the incredible wealth of drug leads hidden just beneath the ocean surface.	Bryostatins	67-77	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
19206287-1	2008	We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins.	Histidine	192-201	histidine triad nucleotide binding protein 1	Homo sapiens	230-235
18799291-1	2008	BACKGROUND: : The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5"-monophosphoramidate substrates such as AMP-morpholidate.	adenosine 5"-monophosphoramidate	82-114	histidine triad nucleotide binding protein 1	Homo sapiens	18-62
18799291-1	2008	BACKGROUND: : The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5"-monophosphoramidate substrates such as AMP-morpholidate.	adenosine 5"-monophosphoramidate	82-114	histidine triad nucleotide binding protein 1	Homo sapiens	64-69
18799291-1	2008	BACKGROUND: : The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5"-monophosphoramidate substrates such as AMP-morpholidate.	amp-morpholidate	134-150	histidine triad nucleotide binding protein 1	Homo sapiens	18-62
18799291-1	2008	BACKGROUND: : The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5"-monophosphoramidate substrates such as AMP-morpholidate.	amp-morpholidate	134-150	histidine triad nucleotide binding protein 1	Homo sapiens	64-69
18652891-2	2008	In this study, we found that intracerebroventricular (icv) administration of morphine recruits PKC isoforms, mostly PKCgamma, to the MOR via the HINT1/RGSZ complex.	Morphine	77-85	histidine triad nucleotide binding protein 1	Homo sapiens	145-150
18652891-4	2008	When PKCI/HINT1 expression is depressed, morphine produces stronger analgesic effects and neither the PKCgamma-MOR complex nor serine phosphorylation of this receptor is detected.	Morphine	41-49	histidine triad nucleotide binding protein 1	Homo sapiens	10-15
18596417-7	2008	Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function.	Histidine	63-72	histidine triad nucleotide binding protein 1	Homo sapiens	88-93
17870088-6	2007	Unlike hHint1, hHint3-1 and hHint3-2 prefer AIPA over tryptamine adenosine phosphoramidate by factors of 33- and 16-fold, respectively.	aipa	44-48	histidine triad nucleotide binding protein 1	Homo sapiens	7-36
17870088-12	2007	The extent of active-site His145-AMP labeling was shown to be similar to His112-AMP labeling of hHint1.	his112-amp	73-83	histidine triad nucleotide binding protein 1	Homo sapiens	96-102
17870088-15	2007	Taken together, these results imply that while Hint3 and Hint1 prefer aminoacyl-adenylates as substrates and catalytically interact with aminoacyl-tRNA synthetases, the significant differences in phosphoramidase activity, oligomeric state, and cellular localization suggest that Hint3s should be placed in a distinct branch of the histidine triad superfamily.	Histidine	331-340	histidine triad nucleotide binding protein 1	Homo sapiens	57-62
18644867-2	2008	Moreover, we showed that the dinucleotide diadenosine tetraphosphate (Ap(4)A), previously shown to be synthesized by LysRS, binds to Hint-1, and as a result the transcription factors are released from their suppression.	dinucleotide diadenosine tetraphosphate	29-68	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
18644867-2	2008	Moreover, we showed that the dinucleotide diadenosine tetraphosphate (Ap(4)A), previously shown to be synthesized by LysRS, binds to Hint-1, and as a result the transcription factors are released from their suppression.	diadenosine tetraphosphate	70-76	histidine triad nucleotide binding protein 1	Homo sapiens	133-139
18593937-3	2008	Our results revealed that treatment with cell permeable cGMP derivatives, or the cGMP phosphodiesterase inhibitor sulindac sulfone (exisulind, aptosyn, hereafter called exisulind) led to increased expression of the tumor suppressor proteins p21(CIP1), p27(KIP1), and Histidine triad protein 1 (HINT1), and their corresponding mRNAs.	Cyclic GMP	56-60	histidine triad nucleotide binding protein 1	Homo sapiens	267-292
18593937-3	2008	Our results revealed that treatment with cell permeable cGMP derivatives, or the cGMP phosphodiesterase inhibitor sulindac sulfone (exisulind, aptosyn, hereafter called exisulind) led to increased expression of the tumor suppressor proteins p21(CIP1), p27(KIP1), and Histidine triad protein 1 (HINT1), and their corresponding mRNAs.	Cyclic GMP	56-60	histidine triad nucleotide binding protein 1	Homo sapiens	294-299
18593937-3	2008	Our results revealed that treatment with cell permeable cGMP derivatives, or the cGMP phosphodiesterase inhibitor sulindac sulfone (exisulind, aptosyn, hereafter called exisulind) led to increased expression of the tumor suppressor proteins p21(CIP1), p27(KIP1), and Histidine triad protein 1 (HINT1), and their corresponding mRNAs.	sulindac sulfone	114-130	histidine triad nucleotide binding protein 1	Homo sapiens	267-292
18593937-3	2008	Our results revealed that treatment with cell permeable cGMP derivatives, or the cGMP phosphodiesterase inhibitor sulindac sulfone (exisulind, aptosyn, hereafter called exisulind) led to increased expression of the tumor suppressor proteins p21(CIP1), p27(KIP1), and Histidine triad protein 1 (HINT1), and their corresponding mRNAs.	sulindac sulfone	114-130	histidine triad nucleotide binding protein 1	Homo sapiens	294-299
18593937-4	2008	Overexpression of PKG Ibeta also caused increased expression of the p21(CIP1), p27(KIP1), and HINT1 proteins.	ibeta	22-27	histidine triad nucleotide binding protein 1	Homo sapiens	94-99
18593937-8	2008	Knockdown of Sp1 expression with siRNA inhibited the increased expression of p21(CIP1), p27(KIP1), and HINT1 induced by the cGMP derivative 8-pCPT-cGMP in SW480 cells.	Cyclic GMP	124-128	histidine triad nucleotide binding protein 1	Homo sapiens	103-108
18593937-8	2008	Knockdown of Sp1 expression with siRNA inhibited the increased expression of p21(CIP1), p27(KIP1), and HINT1 induced by the cGMP derivative 8-pCPT-cGMP in SW480 cells.	8-((4-chlorophenyl)thio)cyclic-3',5'-GMP	140-151	histidine triad nucleotide binding protein 1	Homo sapiens	103-108
17939685-5	2007	In addition, the studies with each chimera revealed that differences in the ability of hHint1 and echinT to hydrolyze lysyl-AMP generated by either E. coli or human lysyl-tRNA synthetase were partially transferable by C-terminal loop exchange.	lysyl-amp	118-127	histidine triad nucleotide binding protein 1	Homo sapiens	87-93
17520123-1	2007	The Hint-1 hydrolase assisted cleavage of the P-N bond in adenosine-5"-O-[N-(tryptophanylamide)]phosphoramidothioate proceeds with retention of configuration at the phosphorus atom which is consistent with the formation of a covalent enzyme-substrate complex.	adenosine-5'-O-(N-(tryptophanylamide))phosphoramidothioate	58-116	histidine triad nucleotide binding protein 1	Homo sapiens	4-10
17520123-1	2007	The Hint-1 hydrolase assisted cleavage of the P-N bond in adenosine-5"-O-[N-(tryptophanylamide)]phosphoramidothioate proceeds with retention of configuration at the phosphorus atom which is consistent with the formation of a covalent enzyme-substrate complex.	Phosphorus	165-175	histidine triad nucleotide binding protein 1	Homo sapiens	4-10
17337452-2	2007	Hint1 catalyzes the hydrolysis of purine phosphoramidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS).	purine phosphoramidates	34-57	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
17337452-2	2007	Hint1 catalyzes the hydrolysis of purine phosphoramidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS).	lysyladenylate	62-77	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Valine	178-181	histidine triad nucleotide binding protein 1	Homo sapiens	92-97
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Valine	178-181	histidine triad nucleotide binding protein 1	Homo sapiens	128-133
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Valine	178-181	histidine triad nucleotide binding protein 1	Homo sapiens	135-141
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Aspartic Acid	201-204	histidine triad nucleotide binding protein 1	Homo sapiens	92-97
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Aspartic Acid	201-204	histidine triad nucleotide binding protein 1	Homo sapiens	128-133
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Aspartic Acid	201-204	histidine triad nucleotide binding protein 1	Homo sapiens	135-141
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Glutamic Acid	206-209	histidine triad nucleotide binding protein 1	Homo sapiens	92-97
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Glutamic Acid	206-209	histidine triad nucleotide binding protein 1	Homo sapiens	135-141
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Arginine	214-217	histidine triad nucleotide binding protein 1	Homo sapiens	135-141
17510397-1	2007	There is accumulating evidence that histidine triad (HIT) nucleotide-binding protein 1 (HINT1), a member of the evolutionary highly conserved HIT protein super family, is a novel tumor suppressor.	Histidine	36-45	histidine triad nucleotide binding protein 1	Homo sapiens	88-93
17510397-4	2007	This cell line also displayed partial methylation of the promoter region of the Hint1 gene, and treatment of these cells with 5-azadeoxycitidine increased expression of Hint1 mRNA and protein.	5-azadeoxycitidine	126-144	histidine triad nucleotide binding protein 1	Homo sapiens	80-85
17510397-4	2007	This cell line also displayed partial methylation of the promoter region of the Hint1 gene, and treatment of these cells with 5-azadeoxycitidine increased expression of Hint1 mRNA and protein.	5-azadeoxycitidine	126-144	histidine triad nucleotide binding protein 1	Homo sapiens	169-174
17337452-7	2007	hHint1 was shown to prefer 3-indolepropionic acyl-adenylate (AIPA) over tryptamine adenosine phosphoramidate monoester (TpAd).	3-indolepropionic acyl-adenylate	27-59	histidine triad nucleotide binding protein 1	Homo sapiens	0-6
17337452-7	2007	hHint1 was shown to prefer 3-indolepropionic acyl-adenylate (AIPA) over tryptamine adenosine phosphoramidate monoester (TpAd).	aipa	61-65	histidine triad nucleotide binding protein 1	Homo sapiens	0-6
17337452-7	2007	hHint1 was shown to prefer 3-indolepropionic acyl-adenylate (AIPA) over tryptamine adenosine phosphoramidate monoester (TpAd).	tryptamine adenosine phosphoramidate	72-108	histidine triad nucleotide binding protein 1	Homo sapiens	0-6
17337452-9	2007	Adenylation of wild-type, V97D, and V97E hHint1 by human LysRS was shown to correlate with the mutant k(cat)/K(m) values using 3-indolepropionic acyl-adenylate as a substrate, but not tryptamine adenosine phosphoramidate monoester.	3-indolepropionic acyl-adenylate	127-159	histidine triad nucleotide binding protein 1	Homo sapiens	41-47
17337452-9	2007	Adenylation of wild-type, V97D, and V97E hHint1 by human LysRS was shown to correlate with the mutant k(cat)/K(m) values using 3-indolepropionic acyl-adenylate as a substrate, but not tryptamine adenosine phosphoramidate monoester.	tryptamine adenosine phosphoramidate	184-220	histidine triad nucleotide binding protein 1	Homo sapiens	41-47
17337452-11	2007	Taken together, these results demonstrate that for hHint1; 1) the efficiency (k(cat)/K(m)) of acylated AMP hydrolysis, but not maximal catalytic turnover (k(cat)), is dependent on homodimerization and 2) the hydrolysis of lysyl-AMP generated by LysRS is not dependent on homodimerization if the monomer structure is similar to the wild-type structure.	Adenosine Monophosphate	103-106	histidine triad nucleotide binding protein 1	Homo sapiens	51-57
17337452-11	2007	Taken together, these results demonstrate that for hHint1; 1) the efficiency (k(cat)/K(m)) of acylated AMP hydrolysis, but not maximal catalytic turnover (k(cat)), is dependent on homodimerization and 2) the hydrolysis of lysyl-AMP generated by LysRS is not dependent on homodimerization if the monomer structure is similar to the wild-type structure.	lysyl-amp	222-231	histidine triad nucleotide binding protein 1	Homo sapiens	51-57
17158446-6	2007	By varying time and the concentrations of lysine, Mg(2+), or LysRS, the adenylation of Hint was found to be dependent on the formation of lysyl-AMP.	Lysine	42-48	histidine triad nucleotide binding protein 1	Homo sapiens	87-91
17126529-2	2007	The cysteine string region, unique to the RZ subfamily, contributes to the observed interaction because PKCI-1 interacted with N-terminus of RGS17 and GAIP, but not with that of RGS2 or RGS7 where cysteine string motif is absent.	Cysteine	4-12	histidine triad nucleotide binding protein 1	Homo sapiens	104-110
17126529-2	2007	The cysteine string region, unique to the RZ subfamily, contributes to the observed interaction because PKCI-1 interacted with N-terminus of RGS17 and GAIP, but not with that of RGS2 or RGS7 where cysteine string motif is absent.	Cysteine	197-205	histidine triad nucleotide binding protein 1	Homo sapiens	104-110
17126529-13	2007	Inhibition of cAMP by mu opioid receptor was significantly reduced by RGSZ1 and this effect was enhanced in combination with PKCI-1.	Cyclic AMP	14-18	histidine triad nucleotide binding protein 1	Homo sapiens	125-131
17217311-5	2007	A series of substrates linking the naturally fluorogenic indole derivatives to nucleoside 5"-monophosphates were synthesized, and their steady state kinetic parameters of hydrolysis by human Hint1 and Escherichia coli hinT were evaluated.	indole	57-63	histidine triad nucleotide binding protein 1	Homo sapiens	191-196
17217311-5	2007	A series of substrates linking the naturally fluorogenic indole derivatives to nucleoside 5"-monophosphates were synthesized, and their steady state kinetic parameters of hydrolysis by human Hint1 and Escherichia coli hinT were evaluated.	nucleoside 5"-monophosphates	79-107	histidine triad nucleotide binding protein 1	Homo sapiens	191-196
17217311-7	2007	While a stereochemical preference was not observed for E. coli hinT, hHint1 exhibited a 300-fold preference for d-tryptophan phosphoramidates over l-isomers.	D-Tryptophan	112-124	histidine triad nucleotide binding protein 1	Homo sapiens	69-75
17217311-7	2007	While a stereochemical preference was not observed for E. coli hinT, hHint1 exhibited a 300-fold preference for d-tryptophan phosphoramidates over l-isomers.	phosphoramidic acid	125-141	histidine triad nucleotide binding protein 1	Homo sapiens	69-75
17217311-9	2007	The apparent second-order rate constants (kcat/Km) for adenosine tryptamine phosphoramidate monoester were found to be 107 M-1 s-1 for hHint1 and 106 M-1 s-1 for E. coli hinT.	adenosine tryptamine phosphoramidate	55-91	histidine triad nucleotide binding protein 1	Homo sapiens	135-157
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	53-62	histidine triad nucleotide binding protein 1	Homo sapiens	161-165
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	53-62	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	142-145	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	142-145	histidine triad nucleotide binding protein 1	Homo sapiens	161-165
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	142-145	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	169-172	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17158446-6	2007	By varying time and the concentrations of lysine, Mg(2+), or LysRS, the adenylation of Hint was found to be dependent on the formation of lysyl-AMP.	Magnesium	50-52	histidine triad nucleotide binding protein 1	Homo sapiens	87-91
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	169-172	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Alanine	202-209	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Glycine	213-220	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17158446-6	2007	By varying time and the concentrations of lysine, Mg(2+), or LysRS, the adenylation of Hint was found to be dependent on the formation of lysyl-AMP.	lysyl-amp	138-147	histidine triad nucleotide binding protein 1	Homo sapiens	87-91
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Glycine	213-220	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	53-62	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
16099717-7	2005	The elevated nighttime excretion, with values similar to those in the daytime, hint at a possibly elevated fluid, sodium, and chloride intake during daytime.	Sodium	114-120	histidine triad nucleotide binding protein 1	Homo sapiens	79-83
18058549-0	2007	Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1.	protides	51-59	histidine triad nucleotide binding protein 1	Homo sapiens	98-103
18058549-1	2007	The aim of the present work is to investigate through molecular modelling the possible role of the human enzyme Hint1 in the final P-N bond cleavage of phosphoramidate ProTides, which would lead to the intracellular delivery of unmasked nucleoside analogue monophosphates.	phosphoramidic acid	152-167	histidine triad nucleotide binding protein 1	Homo sapiens	112-117
18058549-1	2007	The aim of the present work is to investigate through molecular modelling the possible role of the human enzyme Hint1 in the final P-N bond cleavage of phosphoramidate ProTides, which would lead to the intracellular delivery of unmasked nucleoside analogue monophosphates.	protides	168-176	histidine triad nucleotide binding protein 1	Homo sapiens	112-117
18058549-1	2007	The aim of the present work is to investigate through molecular modelling the possible role of the human enzyme Hint1 in the final P-N bond cleavage of phosphoramidate ProTides, which would lead to the intracellular delivery of unmasked nucleoside analogue monophosphates.	nucleoside analogue monophosphates	237-271	histidine triad nucleotide binding protein 1	Homo sapiens	112-117
18058549-2	2007	Herein, we report our preliminary analysis based on docking studies of (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVdU) related aminoacyl phosphates with Hint1 and the effect of the amino acid moiety on the enzyme-substrate binding affinity.	brivudine	71-107	histidine triad nucleotide binding protein 1	Homo sapiens	149-154
18058549-2	2007	Herein, we report our preliminary analysis based on docking studies of (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVdU) related aminoacyl phosphates with Hint1 and the effect of the amino acid moiety on the enzyme-substrate binding affinity.	brivudine	109-113	histidine triad nucleotide binding protein 1	Homo sapiens	149-154
18058549-2	2007	Herein, we report our preliminary analysis based on docking studies of (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVdU) related aminoacyl phosphates with Hint1 and the effect of the amino acid moiety on the enzyme-substrate binding affinity.	aminoacyl phosphates	123-143	histidine triad nucleotide binding protein 1	Homo sapiens	149-154
17113299-3	2007	In lack of experimental structural informations, we performed molecular docking simulations to probe the interactions of benzisothiazolylamidines with matrix metalloproteinase-3, using the docking package GOLD and the software HINT as a post-process scoring function.	benzisothiazolylamidines	121-145	histidine triad nucleotide binding protein 1	Homo sapiens	227-231
16737856-6	2006	A very good correlation was found between the extent of limited tryptic proteolysis and both the hydrogen bond distance between alphaX181 and betaSer178, obtained from the molecular dynamics simulation, and the hydrogen bond strength, evaluated by HINT, an empirical force field that takes into account both enthalpic and entropic contributions.	Hydrogen	211-219	histidine triad nucleotide binding protein 1	Homo sapiens	248-252
16186798-1	2006	The HINT1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues.	Histidine	35-44	histidine triad nucleotide binding protein 1	Homo sapiens	4-9
16214351-1	2006	A 3D-QSAR analysis of a new class of ring-substituted quinolines with anti-tuberculosis activity has been carried out by three methods-Comparative Molecular Field Analysis (CoMFA), CoMFA with inclusion of a hydropathy field (HINT), and Comparative Molecular Similarity Indices Analysis (CoMSIA).	Quinolines	54-64	histidine triad nucleotide binding protein 1	Homo sapiens	225-229
16099717-7	2005	The elevated nighttime excretion, with values similar to those in the daytime, hint at a possibly elevated fluid, sodium, and chloride intake during daytime.	Chlorides	126-134	histidine triad nucleotide binding protein 1	Homo sapiens	79-83
15968115-8	2005	In addition, fluorescence measurements on a solution of threonine synthase appear to hint at a change of the phosphate environment of the cofactor upon activator binding.	Phosphates	109-118	histidine triad nucleotide binding protein 1	Homo sapiens	85-89
16014379-2	2005	In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin.	Histidine	76-85	histidine triad nucleotide binding protein 1	Homo sapiens	15-20
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Lysine	127-133	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
15703176-0	2005	31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.	Salts	145-149	histidine triad nucleotide binding protein 1	Homo sapiens	39-43
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Histidine	51-60	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Adenosine Monophosphate	123-126	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
15703176-5	2005	The E. coli Hint homolog, which had been comprehensively designated ycfF and is here named hinT, was cloned, overexpressed, purified, and characterized with respect to purine nucleoside phosphoramidate substrates.	purine nucleoside phosphoramidate	168-201	histidine triad nucleotide binding protein 1	Homo sapiens	12-16
15703176-9	2005	Physiological analysis of this mutant revealed that the loss of hinT results in failure to grow in media containing 0.75 m KCl, 0.9 m NaCl, 0.5 m NaOAc, or 10 mm MnCl(2).	mncl	162-166	histidine triad nucleotide binding protein 1	Homo sapiens	64-68
15703176-10	2005	Thus, cation-resistant bacterial cell growth may be dependent on the hydrolysis of adenylylated and/or guanylylated phosphoramidate substrates by hinT.	phosphoramidic acid	116-131	histidine triad nucleotide binding protein 1	Homo sapiens	146-150
15703176-5	2005	The E. coli Hint homolog, which had been comprehensively designated ycfF and is here named hinT, was cloned, overexpressed, purified, and characterized with respect to purine nucleoside phosphoramidate substrates.	purine nucleoside phosphoramidate	168-201	histidine triad nucleotide binding protein 1	Homo sapiens	91-95
15703176-9	2005	Physiological analysis of this mutant revealed that the loss of hinT results in failure to grow in media containing 0.75 m KCl, 0.9 m NaCl, 0.5 m NaOAc, or 10 mm MnCl(2).	Potassium Chloride	123-126	histidine triad nucleotide binding protein 1	Homo sapiens	64-68
15703176-9	2005	Physiological analysis of this mutant revealed that the loss of hinT results in failure to grow in media containing 0.75 m KCl, 0.9 m NaCl, 0.5 m NaOAc, or 10 mm MnCl(2).	Sodium Chloride	134-138	histidine triad nucleotide binding protein 1	Homo sapiens	64-68
15703176-9	2005	Physiological analysis of this mutant revealed that the loss of hinT results in failure to grow in media containing 0.75 m KCl, 0.9 m NaCl, 0.5 m NaOAc, or 10 mm MnCl(2).	Sodium Acetate	146-151	histidine triad nucleotide binding protein 1	Homo sapiens	64-68
14965451-6	2003	A direct measure of functional speech perception in noise (Hearing in Noise Test: HINT) has been identified and validated for use in screening applicants for hearing-critical jobs in DFO.	dfo	183-186	histidine triad nucleotide binding protein 1	Homo sapiens	82-86
15490337-7	2004	Also a hint is given to oxygen as a toxic compound though being a chemical prerequisite for aerobic life on earth.	Oxygen	24-30	histidine triad nucleotide binding protein 1	Homo sapiens	7-11
15317462-8	2004	Hydropathic analysis of the energetic contributions using HINT indicates a significant improvement of the correlation between HINT scores and the experimentally determined binding constants when the appropriate bridging water molecules are taken into account.	Water	220-225	histidine triad nucleotide binding protein 1	Homo sapiens	58-62
15317462-8	2004	Hydropathic analysis of the energetic contributions using HINT indicates a significant improvement of the correlation between HINT scores and the experimentally determined binding constants when the appropriate bridging water molecules are taken into account.	Water	220-225	histidine triad nucleotide binding protein 1	Homo sapiens	126-130
15317462-10	2004	HINT was shown to be able to map quantitatively the contribution of individual structural waters to binding energy.	Water	90-96	histidine triad nucleotide binding protein 1	Homo sapiens	0-4
15256063-6	2004	Among these genes, we found that cDNA transfer of Hint/PKCI-1 resulted in a significant in vitro growth inhibition in two cell lines exhibiting 5-aza-dC-induced upregulation of Hint/PKCI-1 and significantly reduced in vivo tumorigenicity of one NSCLC cell line.	Azacitidine	144-149	histidine triad nucleotide binding protein 1	Homo sapiens	50-54
15256063-6	2004	Among these genes, we found that cDNA transfer of Hint/PKCI-1 resulted in a significant in vitro growth inhibition in two cell lines exhibiting 5-aza-dC-induced upregulation of Hint/PKCI-1 and significantly reduced in vivo tumorigenicity of one NSCLC cell line.	Azacitidine	144-149	histidine triad nucleotide binding protein 1	Homo sapiens	55-61
15256063-6	2004	Among these genes, we found that cDNA transfer of Hint/PKCI-1 resulted in a significant in vitro growth inhibition in two cell lines exhibiting 5-aza-dC-induced upregulation of Hint/PKCI-1 and significantly reduced in vivo tumorigenicity of one NSCLC cell line.	Azacitidine	144-149	histidine triad nucleotide binding protein 1	Homo sapiens	177-181
15256063-6	2004	Among these genes, we found that cDNA transfer of Hint/PKCI-1 resulted in a significant in vitro growth inhibition in two cell lines exhibiting 5-aza-dC-induced upregulation of Hint/PKCI-1 and significantly reduced in vivo tumorigenicity of one NSCLC cell line.	Azacitidine	144-149	histidine triad nucleotide binding protein 1	Homo sapiens	182-188
15256063-7	2004	Hint/PKCI-1, which is the only other characterized human histidine triad (HIT) nucleotide-binding protein in addition to tumor-suppressor gene FHIT, might be involved in lung carcinogenesis.	Histidine	57-66	histidine triad nucleotide binding protein 1	Homo sapiens	0-4
15256063-7	2004	Hint/PKCI-1, which is the only other characterized human histidine triad (HIT) nucleotide-binding protein in addition to tumor-suppressor gene FHIT, might be involved in lung carcinogenesis.	Histidine	57-66	histidine triad nucleotide binding protein 1	Homo sapiens	5-11
12433800-3	2002	Computational methods (using Flexidock and HINT in SYBYL) were used to determine the feasibility of (+)- or (-)-chloroephedrine and cis- or trans-1,2-dimethyl-3-phenylaziridine binding in the active site of a three dimensional CYP2D6 molecular model.	(+)- or (-)-chloroephedrine	100-127	histidine triad nucleotide binding protein 1	Homo sapiens	43-47
12492854-3	2003	In Hedgehog proteins the Hint domain autocatalyses its cleavage from the N-terminal domain of the Hedgehog protein by attaching a cholesterol molecule to it.	Cholesterol	130-141	histidine triad nucleotide binding protein 1	Homo sapiens	25-29
12433800-3	2002	Computational methods (using Flexidock and HINT in SYBYL) were used to determine the feasibility of (+)- or (-)-chloroephedrine and cis- or trans-1,2-dimethyl-3-phenylaziridine binding in the active site of a three dimensional CYP2D6 molecular model.	cis- or trans-1,2-dimethyl-3-phenylaziridine	132-176	histidine triad nucleotide binding protein 1	Homo sapiens	43-47
11349819-2	2001	This model, HINT for Hydropathic INTeractions, is shown to include, in very empirical and approximate terms, all components of biomolecular associations, including hydrogen bonding, Coulombic interactions, hydrophobic interactions, entropy and solvation/desolvation.	Hydrogen	164-172	histidine triad nucleotide binding protein 1	Homo sapiens	12-16
11349819-3	2001	Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, deltaGinteraction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands.	Water	361-366	histidine triad nucleotide binding protein 1	Homo sapiens	97-101
11349819-3	2001	Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, deltaGinteraction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands.	Water	361-366	histidine triad nucleotide binding protein 1	Homo sapiens	180-184
10999486-0	2000	HINT predictive analysis of binding between retinol binding protein and hydrophobic ligands.	Vitamin A	44-51	histidine triad nucleotide binding protein 1	Homo sapiens	0-4
10958787-2	2000	Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1.	Histidine	55-64	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
10958787-2	2000	Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1.	Histidine	55-64	histidine triad nucleotide binding protein 1	Homo sapiens	98-104
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	histidine triad nucleotide binding protein 1	Homo sapiens	41-45
10999486-1	2000	The interaction between the retinol binding protein and four ligands was evaluated using HINT, a software based on experimental LogP values of individual atoms.	Vitamin A	28-35	histidine triad nucleotide binding protein 1	Homo sapiens	89-93
10999486-2	2000	A satisfactory correlation was found between the HINT scores and the experimental dissociation constants of three of the ligands, fenretinide, N-ethylretinamide and all-trans retinol, despite their hydrophobic nature.	Fenretinide	130-141	histidine triad nucleotide binding protein 1	Homo sapiens	49-53
10999486-2	2000	A satisfactory correlation was found between the HINT scores and the experimental dissociation constants of three of the ligands, fenretinide, N-ethylretinamide and all-trans retinol, despite their hydrophobic nature.	vitamin A acid ethylamide	143-160	histidine triad nucleotide binding protein 1	Homo sapiens	49-53
10999486-2	2000	A satisfactory correlation was found between the HINT scores and the experimental dissociation constants of three of the ligands, fenretinide, N-ethylretinamide and all-trans retinol, despite their hydrophobic nature.	Vitamin A	165-182	histidine triad nucleotide binding protein 1	Homo sapiens	49-53
10497298-2	1999	Crystal structures of nucleotide-bound forms of histidine triad nucleotide-binding protein (Hint) demonstrated that the conserved residues in HIT proteins are responsible for their distinctive, dimeric, 10-stranded half-barrel structures that form two identical purine nucleotide-binding sites.	purine	262-268	histidine triad nucleotide binding protein 1	Homo sapiens	48-90
10930269-0	2000	Formation of grignard reagents from aryl halides: effective radical probes hint at a nonparticipation of dianions in the mechanism We have prepared highly efficient radical probes 2a-b involving the hex-5-enyl rearrangement.	aryl halides	36-48	histidine triad nucleotide binding protein 1	Homo sapiens	75-79
10930269-0	2000	Formation of grignard reagents from aryl halides: effective radical probes hint at a nonparticipation of dianions in the mechanism We have prepared highly efficient radical probes 2a-b involving the hex-5-enyl rearrangement.	hex-5-enyl	199-209	histidine triad nucleotide binding protein 1	Homo sapiens	75-79
10497298-2	1999	Crystal structures of nucleotide-bound forms of histidine triad nucleotide-binding protein (Hint) demonstrated that the conserved residues in HIT proteins are responsible for their distinctive, dimeric, 10-stranded half-barrel structures that form two identical purine nucleotide-binding sites.	purine	262-268	histidine triad nucleotide binding protein 1	Homo sapiens	92-96
10497298-4	1999	Hint homologs are intracellular receptors for purine mononucleotides whose cellular function remains elusive.	purine mononucleotides	46-68	histidine triad nucleotide binding protein 1	Homo sapiens	0-4
9832352-10	1998	The results of this pilot study should be regarded as a hint at the possible therapeutic benefits of lower fluvoxamine serum concentrations by means of lower fluvoxamine dosages.	Fluvoxamine	107-118	histidine triad nucleotide binding protein 1	Homo sapiens	56-60
9832352-10	1998	The results of this pilot study should be regarded as a hint at the possible therapeutic benefits of lower fluvoxamine serum concentrations by means of lower fluvoxamine dosages.	Fluvoxamine	158-169	histidine triad nucleotide binding protein 1	Homo sapiens	56-60
11666980-0	1996	Oxidative Polymerization of the Pheomelanin Precursor 5-Hydroxy-1,4-benzothiazinylalanine: A New Hint to the Pigment Structure.	pheomelanin	32-43	histidine triad nucleotide binding protein 1	Homo sapiens	97-101
8808164-6	1996	There was a trend for harm, with HINT stopped early because of excess reinfarction with nifedipine, compared with metoprolol.	Nifedipine	88-98	histidine triad nucleotide binding protein 1	Homo sapiens	33-37
11666980-0	1996	Oxidative Polymerization of the Pheomelanin Precursor 5-Hydroxy-1,4-benzothiazinylalanine: A New Hint to the Pigment Structure.	5-hydroxy-1,4-benzothiazinylalanine	54-89	histidine triad nucleotide binding protein 1	Homo sapiens	97-101
34374961-2	2021	Recent rodent and human brain imaging studies suggest involvement of sexually dimorphic, dopaminergic-motivational, mesolimbic circuits in the transition to chronic pain (tCBP), and hint that the combination of carbidopa/levodopa and naproxen (LDP + NPX) may block tCBP.	carbidopa, levodopa drug combination	211-229	histidine triad nucleotide binding protein 1	Homo sapiens	182-186
33803116-0	2021	Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film.	Polymers	50-58	histidine triad nucleotide binding protein 1	Homo sapiens	62-66
34788633-15	2022	In addition, our data give a hint that a macrolide containing regimen is associated with better survival.	Macrolides	41-50	histidine triad nucleotide binding protein 1	Homo sapiens	29-33
2343089-4	1990	However, a hint at the group of halogenated hydrocarbons is only possible, if additional information about miscibility with water is accessible.	Hydrocarbons	44-56	histidine triad nucleotide binding protein 1	Homo sapiens	11-15
2343089-4	1990	However, a hint at the group of halogenated hydrocarbons is only possible, if additional information about miscibility with water is accessible.	Water	124-129	histidine triad nucleotide binding protein 1	Homo sapiens	11-15
34497073-9	2021	RESULTS: We show that NUC-7738 overcomes the cancer resistance mechanisms that limit the activity of 3"-dA and that its activation is dependent on ProTide cleavage by the enzyme histidine triad nucleotide binding protein 1.	cordycepin	101-106	histidine triad nucleotide binding protein 1	Homo sapiens	178-222
34497073-9	2021	RESULTS: We show that NUC-7738 overcomes the cancer resistance mechanisms that limit the activity of 3"-dA and that its activation is dependent on ProTide cleavage by the enzyme histidine triad nucleotide binding protein 1.	CHEBI:29300	147-154	histidine triad nucleotide binding protein 1	Homo sapiens	178-222
34374961-2	2021	Recent rodent and human brain imaging studies suggest involvement of sexually dimorphic, dopaminergic-motivational, mesolimbic circuits in the transition to chronic pain (tCBP), and hint that the combination of carbidopa/levodopa and naproxen (LDP + NPX) may block tCBP.	Naproxen	234-242	histidine triad nucleotide binding protein 1	Homo sapiens	182-186
34270873-5	2021	The chromatographic results and visualization of density functional theory-calculated conformations of the selectors hint on combination of a steric and electronic effect of the triazole ring in the chiral separation of the analytes.	Triazoles	178-186	histidine triad nucleotide binding protein 1	Homo sapiens	117-121
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	remdesivir	125-128	histidine triad nucleotide binding protein 1	Homo sapiens	221-265
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	remdesivir	125-128	histidine triad nucleotide binding protein 1	Homo sapiens	267-272
34370586-2	2021	titled, "Key Metabolic Enzymes in Remdesivir Activation in Lung Cells," validates the canonical McGuigan enzymes (CES1, CTSA, HINT1) involved in remdesivir"s (RDV"s) bioactivation using bioinformatic and biochemical approaches (1).....	remdesivir	34-44	histidine triad nucleotide binding protein 1	Homo sapiens	126-131
34370586-2	2021	titled, "Key Metabolic Enzymes in Remdesivir Activation in Lung Cells," validates the canonical McGuigan enzymes (CES1, CTSA, HINT1) involved in remdesivir"s (RDV"s) bioactivation using bioinformatic and biochemical approaches (1).....	remdesivir	145-155	histidine triad nucleotide binding protein 1	Homo sapiens	126-131
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	Alanine	136-143	histidine triad nucleotide binding protein 1	Homo sapiens	221-265
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	Alanine	136-143	histidine triad nucleotide binding protein 1	Homo sapiens	267-272
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	monophosphate	199-212	histidine triad nucleotide binding protein 1	Homo sapiens	221-265
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	monophosphate	199-212	histidine triad nucleotide binding protein 1	Homo sapiens	267-272
35054788-0	2022	Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5"-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells.	nucleoside 5"-o-selenophosphate	43-74	histidine triad nucleotide binding protein 1	Homo sapiens	14-19
35054788-0	2022	Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5"-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells.	hydrogen selenide	99-116	histidine triad nucleotide binding protein 1	Homo sapiens	14-19
35054788-2	2022	Using biochemical assays (HPLC- and fluorescence-based), we investigated the enzymatic activity of HINT1 towards dGMPSe in comparison with the corresponding thiophosphate nucleoside, i.e., dGMPS.	dgmpse	113-119	histidine triad nucleotide binding protein 1	Homo sapiens	99-104
35054788-6	2022	In conclusion, our comparative experiments with dGMPSe and dGMPS indicate that the HINT1 enzyme is capable of converting (d)NMPSe to (d)NMP and H2Se, both in vitro and intracellularly.	dgmpse	48-54	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
35054788-6	2022	In conclusion, our comparative experiments with dGMPSe and dGMPS indicate that the HINT1 enzyme is capable of converting (d)NMPSe to (d)NMP and H2Se, both in vitro and intracellularly.	N-methylpyrrolidone	136-139	histidine triad nucleotide binding protein 1	Homo sapiens	83-88
35054788-6	2022	In conclusion, our comparative experiments with dGMPSe and dGMPS indicate that the HINT1 enzyme is capable of converting (d)NMPSe to (d)NMP and H2Se, both in vitro and intracellularly.	hydrogen selenide	144-148	histidine triad nucleotide binding protein 1	Homo sapiens	83-88