PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
19167758-6	2010	Carbohydrate moiety of AGP was found to be critical, since experimentally desialylated protein does not maintain its exocytosis-modulatory activity.	Carbohydrates	0-12	alpha-1-acid glycoprotein	Bos taurus	23-26
19778549-5	2010	TTX also bound non-specifically to H. otakii plasma proteins, BSA, and bovine AGP.	Tetrodotoxin	0-3	alpha-1-acid glycoprotein	Bos taurus	78-81
19778549-6	2010	The amount of the bound TTX in the plasma of H. otakii and BSA, respectively, was 1.86+/-0.36 and 4.65+/-0.70 microg TTX/mg protein at 1000 microg TTX/mL, and that in the bovine AGP was 8.78+/-0.25 microg TTX/mg protein at 200 microg TTX/mL.	Tetrodotoxin	24-27	alpha-1-acid glycoprotein	Bos taurus	178-181
17165854-1	2006	N-Linked glycans derived from human and bovine alpha1-acid glycoprotein, as well as chicken egg white albumin, were analyzed by MALDI-TOF mass spectrometry using a novel MALDI matrix consisting of 2,5-dihydroxybenzoic acid (DHB) and aniline.	n-linked glycans	0-16	alpha-1-acid glycoprotein	Bos taurus	47-71
17321601-3	2007	In this paper we investigated the effect of bovine alpha(1)-acid glycoprotein (boAGP) on spontaneous and staurosporine-induced apoptosis of blood derived monocytes purified using magnetic cell sorting techniques.	Staurosporine	105-118	alpha-1-acid glycoprotein	Bos taurus	51-77
17321601-11	2007	These results suggest that the protective effect of AGP is likely mediated by its sialic acid terminal groups.	N-Acetylneuraminic Acid	82-93	alpha-1-acid glycoprotein	Bos taurus	52-55
18692908-9	2008	Bovine AGP dose-dependently inhibited zymosan-induced PMN extracellular release of superoxide anion and hydrogen peroxide without affecting the capacity of PMN to engulf and kill Staphylococcus aureus.	Zymosan	38-45	alpha-1-acid glycoprotein	Bos taurus	7-10
18692908-9	2008	Bovine AGP dose-dependently inhibited zymosan-induced PMN extracellular release of superoxide anion and hydrogen peroxide without affecting the capacity of PMN to engulf and kill Staphylococcus aureus.	Superoxides	83-99	alpha-1-acid glycoprotein	Bos taurus	7-10
18692908-9	2008	Bovine AGP dose-dependently inhibited zymosan-induced PMN extracellular release of superoxide anion and hydrogen peroxide without affecting the capacity of PMN to engulf and kill Staphylococcus aureus.	Hydrogen Peroxide	104-121	alpha-1-acid glycoprotein	Bos taurus	7-10
18692908-10	2008	Moreover, AGP exerted its effect on ROS production regardless of whether PMNs were exposed to AGP prior to or after activation.	Reactive Oxygen Species	36-39	alpha-1-acid glycoprotein	Bos taurus	10-13
18584879-7	2008	Exocytosis studies showed that isolated neutrophils exposed to several challengers, including Zymosan activated serum (ZAS) and phorbol 12-myristate 13-acetate (PMA), which mimic the inflammatory activation, released PMN-AGP as early as 15min.	Zymosan	94-101	alpha-1-acid glycoprotein	Bos taurus	221-224
18584879-7	2008	Exocytosis studies showed that isolated neutrophils exposed to several challengers, including Zymosan activated serum (ZAS) and phorbol 12-myristate 13-acetate (PMA), which mimic the inflammatory activation, released PMN-AGP as early as 15min.	ZAS	119-122	alpha-1-acid glycoprotein	Bos taurus	221-224
18584879-7	2008	Exocytosis studies showed that isolated neutrophils exposed to several challengers, including Zymosan activated serum (ZAS) and phorbol 12-myristate 13-acetate (PMA), which mimic the inflammatory activation, released PMN-AGP as early as 15min.	Tetradecanoylphorbol Acetate	128-159	alpha-1-acid glycoprotein	Bos taurus	221-224
18584879-7	2008	Exocytosis studies showed that isolated neutrophils exposed to several challengers, including Zymosan activated serum (ZAS) and phorbol 12-myristate 13-acetate (PMA), which mimic the inflammatory activation, released PMN-AGP as early as 15min.	Tetradecanoylphorbol Acetate	161-164	alpha-1-acid glycoprotein	Bos taurus	221-224
17692138-8	2007	The MG-AGP glycan pattern was identical to plasma AGP produced by the liver.	Polysaccharides	11-17	alpha-1-acid glycoprotein	Bos taurus	7-10
17692138-9	2007	Several differences were detected, however, between plasma and SC-AGP isoforms, the most evident being the strong degree of fucosylation and the elevated number of di-antennary glycans in SC-AGP.	Polysaccharides	177-184	alpha-1-acid glycoprotein	Bos taurus	191-194
16498615-2	2006	The solution VCD results revealed that AGP has beta-sheet structure, along with a significant amount of alpha-helix as evidenced from a W pattern in the amide I region.	Amides	153-158	alpha-1-acid glycoprotein	Bos taurus	39-42
15943604-0	2005	Alpha-1-acid glycoprotein inhibits phorbol ester-induced but not Fc-receptor-induced generation of reactive oxygen species in bovine peripheral blood neutrophils.	Phorbol Esters	35-48	alpha-1-acid glycoprotein	Bos taurus	0-25
15943604-2	2005	AGP is described as a potent inhibitor of the production of reactive oxygen species (ROS) in human neutrophils.	Reactive Oxygen Species	60-83	alpha-1-acid glycoprotein	Bos taurus	0-3
15943604-2	2005	AGP is described as a potent inhibitor of the production of reactive oxygen species (ROS) in human neutrophils.	Reactive Oxygen Species	85-88	alpha-1-acid glycoprotein	Bos taurus	0-3
15943604-4	2005	The influence of bovine AGP on the production of ROS by bovine peripheral blood polymorphonuclear leucocytes (PMN) was studied using a highly sensitive method approaching its inhibitory mechanism.	Reactive Oxygen Species	49-52	alpha-1-acid glycoprotein	Bos taurus	24-27
15943604-9	2005	The selective inhibitory potential of AGP in comparison with ovalbumin (OVA) and bovine serum albumin (BSA) showed that ROS inhibition was not a mere protein effect.	Reactive Oxygen Species	120-123	alpha-1-acid glycoprotein	Bos taurus	38-41
15943604-10	2005	ROS production was suppressed only if AGP and PMA were simultaneously present with PMN.	Reactive Oxygen Species	0-3	alpha-1-acid glycoprotein	Bos taurus	38-41
15618681-4	2002	Using a model analysis of the interaction, the ligand binding site on human AGP consists of at least 3 partially overlapping subsites: a basic ligand binding site, an acidic ligand binding site and a steroid hormone binding site.	Steroids	200-215	alpha-1-acid glycoprotein	Bos taurus	76-79
15853298-3	2005	Comparison with the ROA spectra of beta-lactoglobulin and N,N"-diacetylchitobiose reveals features consistent with previous suggestions that the peptide component of AGP has a structure based on the lipocalin fold, and that the first two glycosidic links after the N-links to asparagine in the pentasaccharide core are of the beta(1-4)-type.	Asparagine	276-286	alpha-1-acid glycoprotein	Bos taurus	166-169
15853298-3	2005	Comparison with the ROA spectra of beta-lactoglobulin and N,N"-diacetylchitobiose reveals features consistent with previous suggestions that the peptide component of AGP has a structure based on the lipocalin fold, and that the first two glycosidic links after the N-links to asparagine in the pentasaccharide core are of the beta(1-4)-type.	pentasaccharide	294-309	alpha-1-acid glycoprotein	Bos taurus	166-169
14736726-2	2004	Human AGP is a highly negatively charged acidic glycoprotein (pKa = 2.6; isoelectic point = 2.7) with a molecular weight of approximately 37,000 when examined by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and contains di-, tri-, and tetraantennary carbohydrate chains.	Carbohydrates	297-309	alpha-1-acid glycoprotein	Bos taurus	6-9
14736726-4	2004	In sheep AGP, mono- and disialo-diantennary carbohydrate chains were abundant.	Carbohydrates	44-56	alpha-1-acid glycoprotein	Bos taurus	9-12
14736726-9	2004	We found some novel carbohydrate chains containing both N-acetylneuraminic acid and N-glycolylneuraminic acid in bovine AGP.	Carbohydrates	20-32	alpha-1-acid glycoprotein	Bos taurus	120-123
14736726-9	2004	We found some novel carbohydrate chains containing both N-acetylneuraminic acid and N-glycolylneuraminic acid in bovine AGP.	N-Acetylneuraminic Acid	56-79	alpha-1-acid glycoprotein	Bos taurus	120-123
14736726-9	2004	We found some novel carbohydrate chains containing both N-acetylneuraminic acid and N-glycolylneuraminic acid in bovine AGP.	N-glycolylneuraminic acid	84-109	alpha-1-acid glycoprotein	Bos taurus	120-123
15618681-5	2002	Moreover, dog and bovine AGP each have a basic ligand binding site and a steroid hormone binding site, which significantly overlap and affect each other.	Steroids	73-88	alpha-1-acid glycoprotein	Bos taurus	25-28
10546830-6	1999	This method was successfully applied to the analysis of sialic acid in human urinary trypsin inhibitor (hu-UTI), bovine alpha1-acid glycoprotein (alpha1-AGP) and recombinant human erythropoietin (rhu-EPO).	N-Acetylneuraminic Acid	56-67	alpha-1-acid glycoprotein	Bos taurus	120-144
11073082-3	2000	The Mabs reacted with bovine alpha1AGP on immunoblot analysis, but not with alpha1AGP digested with N-glycosidase, suggesting that an epitope recognized by these Mabs may be associated with a glycan side chain of bovine alpha1AGP.	Polysaccharides	192-198	alpha-1-acid glycoprotein	Bos taurus	29-38
11042544-4	2000	The purity of three AGP glycoforms isolated was assessed by hydroxyapatite high-performance liquid chromatography (HPLC), gel-permeation chromatography and SDS-PAGE.	Durapatite	60-74	alpha-1-acid glycoprotein	Bos taurus	20-23
11042544-4	2000	The purity of three AGP glycoforms isolated was assessed by hydroxyapatite high-performance liquid chromatography (HPLC), gel-permeation chromatography and SDS-PAGE.	Sodium Dodecyl Sulfate	156-159	alpha-1-acid glycoprotein	Bos taurus	20-23
10546830-6	1999	This method was successfully applied to the analysis of sialic acid in human urinary trypsin inhibitor (hu-UTI), bovine alpha1-acid glycoprotein (alpha1-AGP) and recombinant human erythropoietin (rhu-EPO).	N-Acetylneuraminic Acid	56-67	alpha-1-acid glycoprotein	Bos taurus	146-156
10546830-7	1999	By combination of CE and HPLC-ITMS we found that N-glycolylneuraminic acid (Neu5Gc) was present in bovine alpha1-AGP in addition to Neu5Ac, with a quantity comparable to that of the latter.	N-glycolylneuraminic acid	49-74	alpha-1-acid glycoprotein	Bos taurus	106-116
10546830-7	1999	By combination of CE and HPLC-ITMS we found that N-glycolylneuraminic acid (Neu5Gc) was present in bovine alpha1-AGP in addition to Neu5Ac, with a quantity comparable to that of the latter.	N-glycolylneuraminic acid	76-82	alpha-1-acid glycoprotein	Bos taurus	106-116
8914612-7	1996	Binding capacities of selected bovine macromolecules for [14C]imidocarb were in the order deoxy-ribonucleic acid (DNA) = ribonucleic acid (RNA) > > alpha 1-acid glycoprotein (AGP) > serum albumin (BSA) > haemoglobin (Hb).	[14c]imidocarb	57-71	alpha-1-acid glycoprotein	Bos taurus	181-184
1586031-6	1992	In cattle with experimentally induced abscesses, serum alpha 1AG concentration increased for 7 to 10 days after F necrophorum inoculation, its change being parallel to that of sialic acid.	N-Acetylneuraminic Acid	176-187	alpha-1-acid glycoprotein	Bos taurus	55-64
7840576-0	1994	Effects of localized Pasteurella haemolytica infection on erythromycin-binding properties of bovine alpha-1-acid glycoprotein, albumin, serum, and tissue chamber fluids.	Erythromycin	58-70	alpha-1-acid glycoprotein	Bos taurus	100-125
7840576-1	1994	The in vitro erythromycin-binding properties of bovine alpha-1-acid glycoprotein (AAG) and albumin were studied by using equilibrium dialysis.	Erythromycin	13-25	alpha-1-acid glycoprotein	Bos taurus	55-80
7840576-1	1994	The in vitro erythromycin-binding properties of bovine alpha-1-acid glycoprotein (AAG) and albumin were studied by using equilibrium dialysis.	Erythromycin	13-25	alpha-1-acid glycoprotein	Bos taurus	82-85
7840576-3	1994	At a concentration of 5 micrograms/ml, erythromycin was moderately bound to AAG (39% +/- 4% free) and was only slightly bound to albumin (86% +/- 2% free).	Erythromycin	39-51	alpha-1-acid glycoprotein	Bos taurus	76-79
7840576-4	1994	Scatchard analysis of the data describing binding to pure bovine AAG indicated that erythromycin was bound to a single high-affinity (6.45 x 10(4) M-1) site on the protein.	Erythromycin	84-96	alpha-1-acid glycoprotein	Bos taurus	65-68
8014861-1	1994	The mechanism by which human alpha-1-acid glycoprotein (hAAG) decreases the intrinsic clearance of prazosin was investigated in primary rat hepatocyte cultures.	Prazosin	99-107	alpha-1-acid glycoprotein	Bos taurus	29-54
8014861-4	1994	In order to identify the underlying mechanism for the observed decrease in uptake the effect of bovine alpha-1-acid glycoprotein (AAG) on prazosin intrinsic clearance and uptake was also determined.	Prazosin	138-146	alpha-1-acid glycoprotein	Bos taurus	103-128
8014861-4	1994	In order to identify the underlying mechanism for the observed decrease in uptake the effect of bovine alpha-1-acid glycoprotein (AAG) on prazosin intrinsic clearance and uptake was also determined.	Prazosin	138-146	alpha-1-acid glycoprotein	Bos taurus	130-133
8014861-6	1994	Based upon the fact that bovine AAG has little or no ability to bind prazosin in contrast to hAAG, we hypothesize that when a AAG, capable of binding prazosin, associated with cell membranes it will retard the diffusion of drug through the cellular stagnant diffusion layer.	Prazosin	150-158	alpha-1-acid glycoprotein	Bos taurus	32-35
8494173-1	1993	A high wavelength fluorescent probe, Nile Red, was added to four proteins, viz., bovine albumin, alpha 1-acid glycoprotein, beta-lactoglobulin and ovomucoid.	nile red	37-45	alpha-1-acid glycoprotein	Bos taurus	97-122
8494173-3	1993	Drug displacement of Nile Red from alpha 1-acid glycoprotein was achieved with both D,L-propranolol and flufenamic acid, showing that the binding site is less electrostatic and more hydrophobic in nature.	nile red	21-29	alpha-1-acid glycoprotein	Bos taurus	35-60
8494173-3	1993	Drug displacement of Nile Red from alpha 1-acid glycoprotein was achieved with both D,L-propranolol and flufenamic acid, showing that the binding site is less electrostatic and more hydrophobic in nature.	Propranolol	84-99	alpha-1-acid glycoprotein	Bos taurus	35-60
8494173-3	1993	Drug displacement of Nile Red from alpha 1-acid glycoprotein was achieved with both D,L-propranolol and flufenamic acid, showing that the binding site is less electrostatic and more hydrophobic in nature.	Flufenamic Acid	104-119	alpha-1-acid glycoprotein	Bos taurus	35-60
1586031-7	1992	High concentration of alpha 1AG was found in naturally affected cattle and was highly correlated to sialic acid concentration.	N-Acetylneuraminic Acid	100-111	alpha-1-acid glycoprotein	Bos taurus	22-31
32544320-5	2020	The selectivity for different glycan types was studied using bovine fetuin, asialofetuin, IgG, ribonuclease B, and alpha-1 acid glycoprotein (AGP) by PGC-LC-MS. Comprehensive structural isomeric separation of glycopeptides was observed by high-resolution MS and confirmed by MS/MS.	Polysaccharides	30-36	alpha-1-acid glycoprotein	Bos taurus	115-140
33131805-5	2021	Bivariate analysis was used to assess the relationship between AGP and DMI.	dmi	71-74	alpha-1-acid glycoprotein	Bos taurus	63-66
33131805-8	2021	On d 3, AGP was associated negatively with DMI in a quadratic manner for wk 1 and wk 2 and linearly for wk 3.	dmi	43-46	alpha-1-acid glycoprotein	Bos taurus	8-11
33131805-9	2021	Day 7 AGP was associated negatively with DMI in a quadratic manner for wk 2 and linearly for wk 3.	dmi	41-44	alpha-1-acid glycoprotein	Bos taurus	6-9
33131805-10	2021	Similarly, d 14 AGP was negatively associated with DMI for wk 3 and wk 4.	dmi	51-54	alpha-1-acid glycoprotein	Bos taurus	16-19
33131805-12	2021	Using bivariate analysis, d 3 AGP explained 10% of the variation in DMI during wk 1.	dmi	68-71	alpha-1-acid glycoprotein	Bos taurus	30-33
33131805-16	2021	These results demonstrate a negative association between plasma AGP concentration and DMI in early-postpartum dairy cows, although its diagnostic performance was marginal.	dmi	86-89	alpha-1-acid glycoprotein	Bos taurus	64-67
33131805-17	2021	Further investigation into whether AGP directly suppresses DMI in dairy cattle is warranted.	dmi	59-62	alpha-1-acid glycoprotein	Bos taurus	35-38
2050770-1	1991	Capillary zone electrophoresis with fused-silica tubes having hydrophilic coating on the inner walls was evaluated in the separation of peptide and glycopeptide fragments from trypsin digestion of alpha 1-acid glycoprotein.	Silicon Dioxide	42-48	alpha-1-acid glycoprotein	Bos taurus	197-222
2050770-5	1991	The oligosaccharides cleaved from human and bovine alpha 1-acid glycoprotein were analyzed after derivatization with 2-aminopyridine, which allowed their sensitive detection by on column UV absorption.	Oligosaccharides	4-20	alpha-1-acid glycoprotein	Bos taurus	51-76
2050770-5	1991	The oligosaccharides cleaved from human and bovine alpha 1-acid glycoprotein were analyzed after derivatization with 2-aminopyridine, which allowed their sensitive detection by on column UV absorption.	alpha-aminopyridine	117-132	alpha-1-acid glycoprotein	Bos taurus	51-76
3252038-9	1988	AAG administration resulted in a 22% decrease in mean unbound fraction of plasma and a 52% increase in mean total plasma propranolol concentration (35% decrease in mean systemic clearance).	Propranolol	121-132	alpha-1-acid glycoprotein	Bos taurus	0-3
32544320-5	2020	The selectivity for different glycan types was studied using bovine fetuin, asialofetuin, IgG, ribonuclease B, and alpha-1 acid glycoprotein (AGP) by PGC-LC-MS. Comprehensive structural isomeric separation of glycopeptides was observed by high-resolution MS and confirmed by MS/MS.	Polysaccharides	30-36	alpha-1-acid glycoprotein	Bos taurus	142-145
30626534-6	2019	Compared to U0, the 40 mg/dL urea (U40) decreased the mRNA expression of TNFA and increased alpha-1-acid glycoprotein (AGP).	Urea	29-33	alpha-1-acid glycoprotein	Bos taurus	92-117
30626534-6	2019	Compared to U0, the 40 mg/dL urea (U40) decreased the mRNA expression of TNFA and increased alpha-1-acid glycoprotein (AGP).	Urea	29-33	alpha-1-acid glycoprotein	Bos taurus	119-122
25123565-7	2014	These findings suggest that oviductal epithelial cells can participate in antimicrobial processes through the secretion of AGP, which is partly regulated by ovarian steroids.	Steroids	165-173	alpha-1-acid glycoprotein	Bos taurus	123-126
25123565-4	2014	Stimulation of bovine oviduct epithelial cells in culture with either progesterone (1 ng/ml) or lipopolysaccharide (LPS, 10 ng/ml) induced both mRNA expression and secretion of AGP.	Progesterone	70-82	alpha-1-acid glycoprotein	Bos taurus	177-180
24530968-7	2014	The high number (9) of glutamic acid residues involved in the ionic interactions might explain the significantly decreased thermostability measured at pH 5.5 (Tm ~ 71  C) with respect to pH 7.4 (Tm ~ 81  C), whereas thermostability of human AGP was only slightly affected by lowering the pH.	Glutamic Acid	23-36	alpha-1-acid glycoprotein	Bos taurus	241-244
24931131-6	2014	Preexposure of PMNs to AGP at physiological levels impaired PMN phagocytosis for sperm and superoxide generation.	Superoxides	91-101	alpha-1-acid glycoprotein	Bos taurus	23-26
24931131-9	2014	Additionally, AGP dose-dependently stimulated BOECs to produce prostaglandin E2 (PGE2) which has been shown to partially contribute to the regulation of sperm phagocytosis in the bovine oviduct.	Dinoprostone	63-79	alpha-1-acid glycoprotein	Bos taurus	14-17
24931131-9	2014	Additionally, AGP dose-dependently stimulated BOECs to produce prostaglandin E2 (PGE2) which has been shown to partially contribute to the regulation of sperm phagocytosis in the bovine oviduct.	Dinoprostone	81-85	alpha-1-acid glycoprotein	Bos taurus	14-17